Selected Cell
Cell:
Value:
PathwayEnrichmentResults_Top30
PathwayNetwork_Top30
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| id | geneSet | link | size | overlap | expect | enrichmentRatio | pValue | FDR | gene_count | genes |
| AKT phosphorylates targets in the cytosol | R-HSA-198323 | http://reactome.org/PathwayBrowser/#/R-HSA-198323 | 14 | 3 | 0.12072396474936 | 24.8500784929356 | 2.10786642844684E-4 | 0.002807743953517 | 3 | AKT1;BAD;MDM2 |
| Activation of BAD and translocation to mitochondria | R-HSA-111447 | http://reactome.org/PathwayBrowser/#/R-HSA-111447 | 15 | 4 | 0.1293471050886 | 30.9245421245421 | 6.56811022414771E-6 | 1.89807253087658E-4 | 4 | AKT1;BAD;BCL2;YWHAZ |
| Activation of the AP-1 family of transcription factors | R-HSA-450341 | http://reactome.org/PathwayBrowser/#/R-HSA-450341 | 10 | 3 | 0.0862314033924002 | 34.7901098901098 | 7.12512520611996E-5 | 0.0011681094688879 | 3 | FOS;JUN;MAPK1 |
| BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | R-HSA-111453 | http://reactome.org/PathwayBrowser/#/R-HSA-111453 | 9 | 3 | 0.0776082630531602 | 38.6556776556776 | 5.01892047759522E-5 | 8.91381188989568E-4 | 3 | BAD;BCL2;STAT3 |
| CD209 (DC-SIGN) signaling | R-HSA-5621575 | http://reactome.org/PathwayBrowser/#/R-HSA-5621575 | 21 | 4 | 0.18108594712404 | 22.0889586603872 | 2.76802272632936E-5 | 5.30278511055232E-4 | 4 | EP300;FYN;NFKB1;RELA |
| CLEC7A/inflammasome pathway | R-HSA-5660668 | http://reactome.org/PathwayBrowser/#/R-HSA-5660668 | 6 | 2 | 0.0517388420354401 | 38.6556776556776 | 0.0010786418512613 | 0.0118650603638752 | 2 | NFKB1;RELA |
| Caspase-mediated cleavage of cytoskeletal proteins | R-HSA-264870 | http://reactome.org/PathwayBrowser/#/R-HSA-264870 | 12 | 3 | 0.10347768407088 | 28.9917582417582 | 1.29002238526743E-4 | 0.0018639730227804 | 3 | CASP3;GSN;VIM |
| Cross-presentation of particulate exogenous antigens (phagosomes) | R-HSA-1236973 | http://reactome.org/PathwayBrowser/#/R-HSA-1236973 | 8 | 2 | 0.0689851227139202 | 28.9917582417582 | 0.0019909477391449 | 0.019070594917091 | 2 | CYBA;NCF1 |
| Detoxification of Reactive Oxygen Species | R-HSA-3299685 | http://reactome.org/PathwayBrowser/#/R-HSA-3299685 | 37 | 8 | 0.319056192551881 | 25.073953073953 | 7.03514357880408E-10 | 1.49936497523262E-7 | 8 | CAT;CYBA;GSR;NCF1;PRDX6;SOD1;SOD2;TXN |
| Growth hormone receptor signaling | R-HSA-982772 | http://reactome.org/PathwayBrowser/#/R-HSA-982772 | 24 | 5 | 0.20695536814176 | 24.1597985347985 | 1.59382684372655E-6 | 7.15377019204025E-5 | 5 | MAPK1;PTPN6;SOCS1;STAT1;STAT3 |
| Inflammasomes | R-HSA-622312 | http://reactome.org/PathwayBrowser/#/R-HSA-622312 | 20 | 5 | 0.1724628067848 | 28.9917582417582 | 5.97414027359022E-7 | 3.51238247119701E-5 | 5 | BCL2;NFKB1;RELA;TXN;TXNIP |
| Interleukin-15 signaling | R-HSA-8983432 | http://reactome.org/PathwayBrowser/#/R-HSA-8983432 | 14 | 3 | 0.12072396474936 | 24.8500784929356 | 2.10786642844684E-4 | 0.002807743953517 | 3 | JAK1;JAK3;STAT3 |
| Interleukin-27 signaling | R-HSA-9020956 | http://reactome.org/PathwayBrowser/#/R-HSA-9020956 | 11 | 3 | 0.0948545437316402 | 31.6273726273726 | 9.7359061077551E-5 | 0.0015210466079571 | 3 | JAK1;STAT1;STAT3 |
| Interleukin-9 signaling | R-HSA-8985947 | http://reactome.org/PathwayBrowser/#/R-HSA-8985947 | 9 | 4 | 0.0776082630531602 | 51.5409035409035 | 6.30814504631871E-7 | 3.58512910132446E-5 | 4 | JAK1;JAK3;STAT1;STAT3 |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | http://reactome.org/PathwayBrowser/#/R-HSA-3134973 | 5 | 2 | 0.0431157016962001 | 46.3868131868131 | 7.23153434194046E-4 | 0.0082198440353389 | 2 | CTNNB1;EP300 |
| Loss of Function of SMAD2/3 in Cancer | R-HSA-3304349 | http://reactome.org/PathwayBrowser/#/R-HSA-3304349 | 7 | 4 | 0.0603619823746801 | 66.2668759811617 | 1.77559907998947E-7 | 1.37608928699184E-5 | 4 | SMAD2;SMAD4;TGFB1;TGFBR1 |
| MAPK1 (ERK2) activation | R-HSA-112411 | http://reactome.org/PathwayBrowser/#/R-HSA-112411 | 9 | 2 | 0.0776082630531602 | 25.7704517704517 | 0.0025454501775361 | 0.0236621998664582 | 2 | JAK1;MAPK1 |
| NF-kB is activated and signals survival | R-HSA-209560 | http://reactome.org/PathwayBrowser/#/R-HSA-209560 | 13 | 3 | 0.11210082441012 | 26.7616229923922 | 1.66657049327501E-4 | 0.0023483493314329 | 3 | IRAK1;NFKB1;RELA |
| NTRK2 activates RAC1 | R-HSA-9032759 | http://reactome.org/PathwayBrowser/#/R-HSA-9032759 | 5 | 2 | 0.0431157016962001 | 46.3868131868131 | 7.23153434194046E-4 | 0.0082198440353389 | 2 | FYN;RAC1 |
| PI3K/AKT activation | R-HSA-198203 | http://reactome.org/PathwayBrowser/#/R-HSA-198203 | 9 | 2 | 0.0776082630531602 | 25.7704517704517 | 0.0025454501775361 | 0.0236621998664582 | 2 | PIK3R1;RHOA |
| PI5P Regulates TP53 Acetylation | R-HSA-6811555 | http://reactome.org/PathwayBrowser/#/R-HSA-6811555 | 9 | 2 | 0.0776082630531602 | 25.7704517704517 | 0.0025454501775361 | 0.0236621998664582 | 2 | EP300;TP53 |
| RHO GTPases Activate NADPH Oxidases | R-HSA-5668599 | http://reactome.org/PathwayBrowser/#/R-HSA-5668599 | 13 | 4 | 0.11210082441012 | 35.6821639898563 | 3.48620252399456E-6 | 1.14307217373283E-4 | 4 | CYBA;NCF1;PIK3C3;RAC1 |
| RSK activation | R-HSA-444257 | http://reactome.org/PathwayBrowser/#/R-HSA-444257 | 6 | 3 | 0.0517388420354401 | 57.9835164835164 | 1.21766000593659E-5 | 3.00885552191578E-4 | 3 | MAPK1;PDPK1;RPS6KA3 |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | http://reactome.org/PathwayBrowser/#/R-HSA-8941855 | 7 | 3 | 0.0603619823746801 | 49.7001569858712 | 2.11758801728079E-5 | 4.3499850234503E-4 | 3 | SMAD4;TGFB1;TP53 |
| RUNX3 regulates p14-ARF | R-HSA-8951936 | http://reactome.org/PathwayBrowser/#/R-HSA-8951936 | 9 | 2 | 0.0776082630531602 | 25.7704517704517 | 0.0025454501775361 | 0.0236621998664582 | 2 | EP300;TGFB1 |
| Regulation of IFNG signaling | R-HSA-877312 | http://reactome.org/PathwayBrowser/#/R-HSA-877312 | 14 | 5 | 0.12072396474936 | 41.416797488226 | 8.03594217835268E-8 | 7.44567954946122E-6 | 5 | IFNG;JAK1;PTPN6;SOCS1;STAT1 |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | http://reactome.org/PathwayBrowser/#/R-HSA-3304356 | 6 | 3 | 0.0517388420354401 | 57.9835164835164 | 1.21766000593659E-5 | 3.00885552191578E-4 | 3 | SMAD2;TGFB1;TGFBR1 |
| Sema3A PAK dependent Axon repulsion | R-HSA-399954 | http://reactome.org/PathwayBrowser/#/R-HSA-399954 | 16 | 3 | 0.13797024542784 | 21.7438186813186 | 3.2025853330353E-4 | 0.0039856992648359 | 3 | FYN;HSP90AA1;RAC1 |
| Sema4D mediated inhibition of cell attachment and migration | R-HSA-416550 | http://reactome.org/PathwayBrowser/#/R-HSA-416550 | 8 | 2 | 0.0689851227139202 | 28.9917582417582 | 0.0019909477391449 | 0.019070594917091 | 2 | RAC1;RHOA |
| The NLRP3 inflammasome | R-HSA-844456 | http://reactome.org/PathwayBrowser/#/R-HSA-844456 | 15 | 4 | 0.1293471050886 | 30.9245421245421 | 6.56811022414771E-6 | 1.89807253087658E-4 | 4 | NFKB1;RELA;TXN;TXNIP |
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| Note: Edges are drawn between pathways based on their common genes, and the edge width is based on the number of those genes. | |||||||||
