Selected Cell
Cell:
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PathwayEnrichmentResults_Top30
PathwayNetwork_Top30
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| id | geneSet | link | size | overlap | expect | enrichmentRatio | pValue | FDR | gene_count | genes |
| AKT phosphorylates targets in the cytosol | R-HSA-198323 | http://reactome.org/PathwayBrowser/#/R-HSA-198323 | 14 | 3 | 0.132663697526769 | 22.6135714285714 | 2.78590493337338E-4 | 0.0045672768378861 | 3 | AKT1;CASP9;CDKN1A |
| AKT phosphorylates targets in the nucleus | R-HSA-198693 | http://reactome.org/PathwayBrowser/#/R-HSA-198693 | 9 | 2 | 0.0852838055529233 | 23.4511111111111 | 0.0030646740603866 | 0.0262576345374839 | 2 | AKT1;FOXO1 |
| Activation of caspases through apoptosome-mediated cleavage | R-HSA-111459 | http://reactome.org/PathwayBrowser/#/R-HSA-111459 | 5 | 2 | 0.0473798919738463 | 42.212 | 8.72644786142906E-4 | 0.0096614244180107 | 2 | CASP3;CASP9 |
| Activation of the AP-1 family of transcription factors | R-HSA-450341 | http://reactome.org/PathwayBrowser/#/R-HSA-450341 | 10 | 3 | 0.0947597839476926 | 31.659 | 9.44118958285944E-5 | 0.001939425089009 | 3 | FOS;JUN;MAPK1 |
| Apoptotic cleavage of cell adhesion proteins | R-HSA-351906 | http://reactome.org/PathwayBrowser/#/R-HSA-351906 | 11 | 3 | 0.104235762342461 | 28.780909090909 | 1.28923620684728E-4 | 0.0025266065892811 | 3 | CASP3;CDH1;CTNNB1 |
| CLEC7A/inflammasome pathway | R-HSA-5660668 | http://reactome.org/PathwayBrowser/#/R-HSA-5660668 | 6 | 2 | 0.0568558703686155 | 35.1766666666666 | 0.0013008791078581 | 0.0136913511043094 | 2 | PYCARD;RELA |
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | R-HSA-3134963 | http://reactome.org/PathwayBrowser/#/R-HSA-3134963 | 7 | 2 | 0.0663318487633848 | 30.1514285714285 | 0.001809985442657 | 0.017634429598459 | 2 | NFKB2;RELA |
| GAB1 signalosome | R-HSA-180292 | http://reactome.org/PathwayBrowser/#/R-HSA-180292 | 11 | 3 | 0.104235762342461 | 28.780909090909 | 1.28923620684728E-4 | 0.0025266065892811 | 3 | EGF;EGFR;SRC |
| GRB2 events in EGFR signaling | R-HSA-179812 | http://reactome.org/PathwayBrowser/#/R-HSA-179812 | 7 | 2 | 0.0663318487633848 | 30.1514285714285 | 0.001809985442657 | 0.017634429598459 | 2 | EGF;EGFR |
| IkBA variant leads to EDA-ID | R-HSA-5603029 | http://reactome.org/PathwayBrowser/#/R-HSA-5603029 | 7 | 3 | 0.0663318487633848 | 45.2271428571428 | 2.8113270860941E-5 | 8.87650496627861E-4 | 3 | IKBKB;NFKB2;RELA |
| InlA-mediated entry of Listeria monocytogenes into host cells | R-HSA-8876493 | http://reactome.org/PathwayBrowser/#/R-HSA-8876493 | 9 | 3 | 0.0852838055529233 | 35.1766666666666 | 6.65461393546396E-5 | 0.0015440157699831 | 3 | CDH1;CTNNB1;SRC |
| Interleukin-9 signaling | R-HSA-8985947 | http://reactome.org/PathwayBrowser/#/R-HSA-8985947 | 9 | 3 | 0.0852838055529233 | 35.1766666666666 | 6.65461393546396E-5 | 0.0015440157699831 | 3 | JAK1;STAT1;STAT5A |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | http://reactome.org/PathwayBrowser/#/R-HSA-3134973 | 5 | 2 | 0.0473798919738463 | 42.212 | 8.72644786142906E-4 | 0.0096614244180107 | 2 | CTNNB1;EP300 |
| Loss of Function of SMAD2/3 in Cancer | R-HSA-3304349 | http://reactome.org/PathwayBrowser/#/R-HSA-3304349 | 7 | 3 | 0.0663318487633848 | 45.2271428571428 | 2.8113270860941E-5 | 8.87650496627861E-4 | 3 | SMAD2;SMAD3;SMAD4 |
| MAPK1 (ERK2) activation | R-HSA-112411 | http://reactome.org/PathwayBrowser/#/R-HSA-112411 | 9 | 2 | 0.0852838055529233 | 23.4511111111111 | 0.0030646740603866 | 0.0262576345374839 | 2 | JAK1;MAPK1 |
| NF-kB is activated and signals survival | R-HSA-209560 | http://reactome.org/PathwayBrowser/#/R-HSA-209560 | 13 | 3 | 0.123187719132 | 24.3530769230769 | 2.20406449245924E-4 | 0.003757929959643 | 3 | IKBKB;RELA;TRAF6 |
| NOTCH4 Intracellular Domain Regulates Transcription | R-HSA-9013695 | http://reactome.org/PathwayBrowser/#/R-HSA-9013695 | 20 | 4 | 0.189519567895385 | 21.106 | 3.27328528111348E-5 | 9.3015856738308E-4 | 4 | EP300;HES1;NOTCH1;SMAD3 |
| PTK6 Expression | R-HSA-8849473 | http://reactome.org/PathwayBrowser/#/R-HSA-8849473 | 5 | 2 | 0.0473798919738463 | 42.212 | 8.72644786142906E-4 | 0.0096614244180107 | 2 | HIF1A;NR3C1 |
| PTK6 promotes HIF1A stabilization | R-HSA-8857538 | http://reactome.org/PathwayBrowser/#/R-HSA-8857538 | 6 | 2 | 0.0568558703686155 | 35.1766666666666 | 0.0013008791078581 | 0.0136913511043094 | 2 | EGFR;HIF1A |
| RIP-mediated NFkB activation via ZBP1 | R-HSA-1810476 | http://reactome.org/PathwayBrowser/#/R-HSA-1810476 | 17 | 4 | 0.161091632711077 | 24.8305882352941 | 1.6434491893702E-5 | 6.09148014755695E-4 | 4 | IKBKB;NFKB2;RELA;TLR3 |
| RORA activates gene expression | R-HSA-1368082 | http://reactome.org/PathwayBrowser/#/R-HSA-1368082 | 18 | 4 | 0.170567611105846 | 23.4511111111111 | 2.09766881028583E-5 | 7.29903126844356E-4 | 4 | CPT1A;EP300;PPARA;RORA |
| RUNX3 regulates BCL2L11 (BIM) transcription | R-HSA-8952158 | http://reactome.org/PathwayBrowser/#/R-HSA-8952158 | 5 | 2 | 0.0473798919738463 | 42.212 | 8.72644786142906E-4 | 0.0096614244180107 | 2 | SMAD3;SMAD4 |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | http://reactome.org/PathwayBrowser/#/R-HSA-8941855 | 7 | 3 | 0.0663318487633848 | 45.2271428571428 | 2.8113270860941E-5 | 8.87650496627861E-4 | 3 | CDKN1A;SMAD3;SMAD4 |
| RUNX3 regulates NOTCH signaling | R-HSA-8941856 | http://reactome.org/PathwayBrowser/#/R-HSA-8941856 | 14 | 3 | 0.132663697526769 | 22.6135714285714 | 2.78590493337338E-4 | 0.0045672768378861 | 3 | EP300;HES1;NOTCH1 |
| RUNX3 regulates WNT signaling | R-HSA-8951430 | http://reactome.org/PathwayBrowser/#/R-HSA-8951430 | 8 | 2 | 0.075807827158154 | 26.3825 | 0.0023984234112683 | 0.0216365709852518 | 2 | CCND1;CTNNB1 |
| RUNX3 regulates p14-ARF | R-HSA-8951936 | http://reactome.org/PathwayBrowser/#/R-HSA-8951936 | 9 | 2 | 0.0852838055529233 | 23.4511111111111 | 0.0030646740603866 | 0.0262576345374839 | 2 | CCND1;EP300 |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | http://reactome.org/PathwayBrowser/#/R-HSA-3304356 | 6 | 2 | 0.0568558703686155 | 35.1766666666666 | 0.0013008791078581 | 0.0136913511043094 | 2 | SMAD2;SMAD3 |
| Sema4D mediated inhibition of cell attachment and migration | R-HSA-416550 | http://reactome.org/PathwayBrowser/#/R-HSA-416550 | 8 | 2 | 0.075807827158154 | 26.3825 | 0.0023984234112683 | 0.0216365709852518 | 2 | RHOA;RRAS |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | R-HSA-1474151 | http://reactome.org/PathwayBrowser/#/R-HSA-1474151 | 12 | 3 | 0.113711740737231 | 26.3825 | 1.70716498141487E-4 | 0.0031563093950481 | 3 | AKT1;CALM1;HSP90AA1 |
| The NLRP3 inflammasome | R-HSA-844456 | http://reactome.org/PathwayBrowser/#/R-HSA-844456 | 15 | 4 | 0.142139675921538 | 28.1413333333333 | 9.56405067509269E-6 | 4.40721794622514E-4 | 4 | NFKB2;PYCARD;RELA;TXN |
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| Note: Edges are drawn between pathways based on their common genes, and the edge width is based on the number of those genes. | |||||||||
