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M2_Mac_interactions
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| ENTITYA | ENTITYB | EFFECT | MECHANISM | TAX_ID | PMID | ||||
| MDM2 | EP300 | down-regulates | binding | 9606 | 11070080 | ||||
| HDAC1 | RELA | down-regulates | binding | 9606 | 17183360 | ||||
| MAPK1 | DUSP1 | down-regulates | phosphorylation | 9606 | 16286470 | ||||
| MAPK1 | SMAD2 | down-regulates | phosphorylation | 9606 | 10197981 | ||||
| SIRT1 | TP53 | down-regulates | deacetylation | 9606 | 19047049 | ||||
| SOCS1 | JAK1 | down-regulates | binding | 9606 | 11133764 | ||||
| CASP3 | IKBKB | down-regulates | cleavage | 9606 | 11741536 | ||||
| MAPK8 | BCL2 | down-regulates | phosphorylation | 9606 | 10567572 | ||||
| SOCS3 | STAT3 | down-regulates | 9606 | 21628332 | |||||
| PTPN6 | STAT6 | down-regulates | 9606 | 9852037 | |||||
| PTPN6 | INSR | down-regulates | dephosphorylation | 9606 | 10734133 | ||||
| PTPN6 | STAT3 | down-regulates | dephosphorylation | 9606 | 18508557 | ||||
| SIRT1 | EP300 | down-regulates | deacetylation | 9606 | 19047049 | ||||
| BCL2 | BECN1 | down-regulates | binding | 9606 | 17446862 | ||||
| SIRT1 | EP300 | down-regulates | deacetylation | 9606 | 19047049 | ||||
| SOCS1 | IRAK1 | down-regulates | binding | 9606 | 12433373 | ||||
| CASP3 | IKBKB | down-regulates | cleavage | 9606 | 11741536 | ||||
| MAPK8 | YWHAB | down-regulates | phosphorylation | 9606 | 15696159 | ||||
| MAPK8 | BCL2 | down-regulates | phosphorylation | 9606 | 18570871 | ||||
| BCL2 | BECN1 | down-regulates | binding | 9606 | 18570871 | ||||
| PTPN6 | INSR | down-regulates | dephosphorylation | 9606 | 10734133 | ||||
| BCL2 | BECN1 | down-regulates | binding | 9606 | 17643073 | ||||
| IKBKB | YWHAB | down-regulates | phosphorylation | 9606 | 16024783 | ||||
| DUSP1 | MAPK8 | down-regulates | dephosphorylation | 9606 | 9020184 | ||||
| PTPN6 | INSR | down-regulates | dephosphorylation | 9606 | 10734133 | ||||
| MAPK8 | YWHAZ | down-regulates | phosphorylation | 9606 | 15071501 | ||||
| STAT1 | RELA | down-regulates | binding | 9606 | 16481475 | ||||
| MAPK8 | NR3C1 | down-regulates | phosphorylation | 9606 | 12351702 | ||||
| INSR | CALM1 | down-regulates | phosphorylation | 9606 | 3415247 | ||||
| HSP90AA1 | NR3C1 | down-regulates | binding | 9606 | 21511880 | ||||
| DUSP1 | MAPK1 | down-regulates | dephosphorylation | 9606 | 10617468 | ||||
| MAPK1 | DUSP1 | down-regulates | phosphorylation | 9606 | 16286470 | ||||
| JAK2 | JAK2 | down-regulates | phosphorylation | 9606 | 19364823 | ||||
| CASP3 | IKBKB | down-regulates | cleavage | 9606 | 11741536 | ||||
| CASP3 | GSN | down-regulates | cleavage | 9606 | 9323209 | ||||
| PTEN | STAT5A | down-regulates | dephosphorylation | 9606 | 20596030 | ||||
| CASP3 | IKBKB | down-regulates | cleavage | 9606 | 11741536 | ||||
| JAK2 | MAP3K5 | down-regulates | phosphorylation | 9606 | 19287004 | ||||
| MAPK8 | STAT6 | down-regulates | phosphorylation | 9606 | 21123173 | ||||
| HSPB1 | CASP3 | down-regulates | 9606 | 10544189 | |||||
| PTPN6 | INSR | down-regulates | dephosphorylation | 9606 | 10734133 | ||||
| MAPK8 | BCL2 | down-regulates | phosphorylation | 9606 | 10567572 | ||||
| AKT1 | HSPB1 | down-regulates | phosphorylation | 9606 | 19593530 | ||||
| PTPN6 | JAK1 | down-regulates | dephosphorylation | 9606 | 14624462 | ||||
| CDKN1A | PCNA | down-regulates | binding | 9606 | 22911014 | ||||
| SOCS1 | JAK1 | down-regulates | binding | 9606 | 23663276 | ||||
| AKT1 | NR3C1 | down-regulates | phosphorylation | 9606 | 24291004 | ||||
| IKBKB | NFKB1 | down-regulates | phosphorylation | 9606 | 11158290 | ||||
| RPS6KA3 | MAP3K5 | down-regulates | phosphorylation | 9606 | 23608533 | ||||
| RPS6KA3 | HMGN1 | down-regulates | phosphorylation | 9606 | 11438671 | ||||
| AKT1 | MAP3K5 | down-regulates | phosphorylation | 9606 | 11154276 | ||||
| STAT6 | STAT1 | down-regulates | binding | 9606 | 10982806 | ||||
| RNF7 | CASP3 | down-regulates | ubiquitination | 9606 | 23136067 | ||||
| BCL2 | BAX | down-regulates | binding | 9606 | 8183370 | ||||
| JAK2 | JAK2 | down-regulates | phosphorylation | 9606 | 21841788 | ||||
| IKBKB | IKBKB | down-regulates | phosphorylation | 9606 | 10195894 | ||||
| PTEN | AKT1 | down-regulates | 9606 | 19903340 | |||||
| IKBKB | IKBKB | down-regulates | phosphorylation | 9606 | 10195894 | ||||
| IKBKB | IKBKB | down-regulates | phosphorylation | 9606 | 10195894 | ||||
| IKBKB | IKBKB | down-regulates | phosphorylation | 9606 | 10195894 | ||||
| JAK2 | JAK2 | down-regulates | phosphorylation | 9606 | 15143187 | ||||
| RNF7 | JUN | down-regulates | ubiquitination | 9606 | 23136067 | ||||
| AKT1 | BAX | down-regulates | phosphorylation | 9606 | 14766748 | ||||
| CASP3 | GSN | down-regulates | cleavage | 9606 | 9671712 | ||||
| PINK1 | PTEN | down-regulates | phosphorylation | 9606 | 37940999 | ||||
| STK11 | PTEN | down-regulates | phosphorylation | 9606 | 21779440 | ||||
| MAPK8 | BCL2 | down-regulates | phosphorylation | 9606 | 10567572 | ||||
| SOCS3 | JAK1 | down-regulates | binding | 9606 | 23454976 | ||||
| IKBKB | IKBKB | down-regulates | phosphorylation | 9606 | 10195894 | ||||
| AKT1 | RAC1 | down-regulates | phosphorylation | 9606 | 10617634 | ||||
| RNF7 | HIF1A | down-regulates | ubiquitination | 9606 | 23136067 | ||||
| SOCS3 | STAT3 | down-regulates | 9606 | 24600449 | |||||
| RPS6KA3 | HMGN1 | down-regulates | phosphorylation | 9606 | 11438671 | ||||
| IKBKB | NFKB1 | down-regulates | phosphorylation | 9606 | 11158290 | ||||
| STK11 | PTEN | down-regulates | phosphorylation | 9606 | 18321849 | ||||
| MAPK1 | STK11 | down-regulates | phosphorylation | 9606 | 25846811 | ||||
| TP53 | G6PD | down-regulates | binding | 9606 | 21336310 | ||||
| RPS6KA3 | MAP3K5 | down-regulates | phosphorylation | 9606 | 23608533 | ||||
| PTEN | AKT1 | down-regulates | 9606 | 20596030 | |||||
| IKBKB | IKBKB | down-regulates | phosphorylation | 9606 | 10195894 | ||||
| IKBKB | NFKB1 | down-regulates | phosphorylation | 9606 | 11158290 | ||||
| STK11 | PTEN | down-regulates | phosphorylation | 9606 | 21779440 | ||||
| IKBKB | IKBKB | down-regulates | phosphorylation | 9606 | 10195894 | ||||
| SOCS3 | JAK2 | down-regulates | binding | 9606 | 24600449 | ||||
| AKT1 | RPS6KA3 | down-regulates | phosphorylation | 9606 | 33574926 | ||||
| IKBKB | IKBKB | down-regulates | phosphorylation | 9606 | 10195894 | ||||
| PTPN6 | PKM | down-regulates | dephosphorylation | 9606 | 26959741 | ||||
| HES1 | NR3C1 | down-regulates | 9606 | 24300895 | |||||
| RPS6KA3 | MAP3K5 | down-regulates | phosphorylation | 9606 | 23608533 | ||||
| JAK2 | JAK2 | down-regulates | phosphorylation | 9606 | 21841788 | ||||
| OGA | G6PD | down-regulates | deglycosylation | 9606 | 26399441 | ||||
| IKBKB | IKBKB | down-regulates | phosphorylation | 9606 | 10195894 | ||||
| SIRT1 | RELA | down-regulates | deacetylation | 9606 | 15152190 | ||||
| DUSP1 | JUN | down-regulates | dephosphorylation | 9606 | 26734995 | ||||
| FBP1 | HIF1A | down-regulates | binding | 9606 | 30616754 | ||||
| IKBKB | IKBKB | down-regulates | phosphorylation | 9606 | 10195894 | ||||
| STK11 | STK11 | down-regulates | phosphorylation | 9606 | 11430832 | ||||
| IKBKB | IKBKB | down-regulates | phosphorylation | 9606 | 10195894 | ||||
| MAPK8 | BCL2 | down-regulates | phosphorylation | 9606 | 18570871 | ||||
| PTEN | PIK3CA | down-regulates | 9606 | 18794881 | |||||
| TP53 | BCL2 | down-regulates | binding | 9606 | 19007744 | ||||
| IKBKB | IKBKB | down-regulates | phosphorylation | 9606 | 10195894 | ||||
| AKT1 | IRAK1 | down-regulates | phosphorylation | 9606 | 11976320 | ||||
| IKBKB | IKBKB | down-regulates | phosphorylation | 9606 | 10195894 | ||||
| IKBKB | IKBKB | down-regulates | phosphorylation | 9606 | 10195894 | ||||
| MDM2 | CDKN1A | down-regulates | binding | 9606 | 14761977 | ||||
| IKBKB | NFKB1 | down-regulates | phosphorylation | 9606 | 10469655 | ||||
| MAPK1 | TXNIP | down-regulates | phosphorylation | 9606 | 31320475 | ||||
| MAPK1 | CDKN1A | down-regulates | phosphorylation | 9606 | 19364816 | ||||
| AKT1 | BTK | down-regulates | phosphorylation | 9606 | 23754751 | ||||
| EP300 | TP53 | down-regulates | polyubiquitination | 9606 | 12690203 | ||||
| MDM2 | TP53 | down-regulates | ubiquitination | 9606 | 23150757 | ||||
| MDM2 | HIF1A | down-regulates | ubiquitination | 9606 | 10640274 | ||||
| SIRT1 | TP53 | down-regulates | deacetylation | 9606 | 25280219 | ||||
| PTPN6 | CTNNB1 | down-regulates | dephosphorylation | 9606 | 20840866 | ||||
| PTPN6 | CTNNB1 | down-regulates | dephosphorylation | 9606 | 20840866 | ||||
| JAK2 | MAP3K5 | down-regulates | phosphorylation | 9606 | 19287004 | ||||
| IKBKB | TARDBP | down-regulates | phosphorylation | 9606 | 38197897 | ||||
| IKBKB | TARDBP | down-regulates | phosphorylation | 9606 | 38197897 | ||||
| MDM2 | TP53 | down-regulates | ubiquitination | 9606 | 10935507 | ||||
| SOCS1 | JAK2 | down-regulates | ubiquitination | 9606 | 14522994 | ||||
| IKBKB | NFKB1 | down-regulates | phosphorylation | 9606 | 10469655 | ||||
| IKBKB | NFKB1 | down-regulates | phosphorylation | 9606 | 10469655 | ||||
| AKT1 | BTK | down-regulates | phosphorylation | 9606 | 23754751 | ||||
| MDM2 | TP53 | down-regulates | ubiquitination | 9606 | 22337874 | ||||
| MAPK1 | CDKN1A | down-regulates | phosphorylation | 9606 | 19364816 | ||||
| SOCS1 | STAT1 | down-regulates | transcriptional regulation | 9606 | 16628196 | ||||
| NFE2L2 | GCLC | down-regulates | transcriptional regulation | 9606 | 22459801 | ||||
| PARP1 | SERPINF1 | down-regulates | transcriptional regulation | 9606 | 18312852 | ||||
| NR3C1 | NFKB1 | down-regulates | transcriptional regulation | 9606 | 8639160 | ||||
| MECP2 | CCND1 | down-regulates | transcriptional regulation | 9606 | 15870696 | ||||
| NFKB1 | THBD | down-regulates | transcriptional regulation | 9606 | 17211835 | ||||
| NR3C1 | JUN | down-regulates | transcriptional regulation | 9606 | 8639160 | ||||
| PARP1 | THBD | down-regulates | transcriptional regulation | 9606 | 21489980 | ||||
| MDM2 | CDKN1A | down-regulates | 9606 | 18292944 | |||||
| HDAC1 | DNMT1 | down-regulates | transcriptional regulation | 9606 | 23242655 | ||||
| HES1 | NR3C1 | down-regulates | transcriptional regulation | 9606 | 19129776 | ||||
| HDAC1 | EGR1 | down-regulates | transcriptional regulation | 9606 | 21983014 | ||||
| NR3C1 | ATP1B1 | down-regulates | transcriptional regulation | 9606 | 9694812 | ||||
| SIRT2 | CDKN1A | down-regulates | transcriptional regulation | 9606 | 14522900 | ||||
| AKT1 | HMOX1 | unknown | phosphorylation | 9606 | 15581622 | ||||
| STK11 | PTEN | unknown | phosphorylation | 9606 | 15987703 | ||||
| AKT1 | YWHAZ | unknown | phosphorylation | 9606 | 11956222 | ||||
| TGFBR1 | PIK3R1 | up-regulates | binding | 9606 | 9435577 | ||||
| INSR | PTPN6 | up-regulates | phosphorylation | 9606 | 7512963 | ||||
| CASP3 | ROCK1 | up-regulates | cleavage | 9606 | 11283607 | ||||
| AKT1 | NCF1 | up-regulates | phosphorylation | 9606 | 10559253 | ||||
| AKT1 | MDM2 | up-regulates | phosphorylation | 9606 | 15169778 | ||||
| STAT3 | TGFB1 | up-regulates | transcriptional regulation | 9606 | 22378047 | ||||
| MAPK8 | BCL2 | up-regulates | phosphorylation | 9606 | 18570871 | ||||
| MAPK1 | DUSP1 | up-regulates | phosphorylation | 9606 | 10617468 | ||||
| MAPK8 | SIRT1 | up-regulates | phosphorylation | 9606 | 20027304 | ||||
| RAC1 | MAPK8 | up-regulates | binding | 9606 | 17251915 | ||||
| MAPK1 | PRDX6 | up-regulates | phosphorylation | 9606 | 19140803 | ||||
| MAPK8 | BCL2 | up-regulates | phosphorylation | 9606 | 10567572 | ||||
| PIK3CA | RAC1 | up-regulates | 9606 | 21779497 | |||||
| MAPK1 | SMAD4 | up-regulates | phosphorylation | 9606 | 12801888 | ||||
| MAPK1 | SMAD2 | up-regulates | phosphorylation | 9606 | 12193595 | ||||
| MAPK8 | SIRT1 | up-regulates | phosphorylation | 9606 | 20027304 | ||||
| MIF | CD74 | up-regulates | binding | 9606 | 12782713 | ||||
| MAPK1 | NCF1 | up-regulates | phosphorylation | 9606 | 16778989 | ||||
| MAPK1 | EP300 | up-regulates | phosphorylation | 9606 | 17623675 | ||||
| EP300 | DUSP1 | up-regulates | acetylation | 9606 | 20626350 | ||||
| AKT1 | NCF1 | up-regulates | phosphorylation | 9606 | 10559253 | ||||
| ILK | AKT1 | up-regulates | phosphorylation | 9606 | 9736715 | ||||
| MAPK8 | IRF3 | up-regulates | phosphorylation | 9606 | 19153595 | ||||
| TLR4 | TLR4 | up-regulates | binding | 9606 | 24352680 | ||||
| TP53 | BAX | up-regulates | binding | 9606 | 16151013 | ||||
| MAPK1 | SMAD2 | up-regulates | phosphorylation | 9606 | 12193595 | ||||
| EP300 | TP53 | up-regulates | acetylation | 9606 | 11070080 | ||||
| HDAC1 | CCND1 | up-regulates | binding | 9606 | 15713663 | ||||
| AKT1 | VCP | up-regulates | phosphorylation | 9606 | 16551632 | ||||
| IRAK1 | STAT3 | up-regulates | phosphorylation | 9606 | 15465816 | ||||
| TGFB1 | TGFBR1 | up-regulates | binding | 9606 | 26194464 | ||||
| ROCK2 | DPYSL2 | up-regulates | phosphorylation | 9606 | 10818093 | ||||
| MAP3K5 | CDKN1A | up-regulates | phosphorylation | 9606 | 17325029 | ||||
| MAPK1 | HIF1A | up-regulates | phosphorylation | 9606 | 18519666 | ||||
| PYCARD | BAX | up-regulates | relocalization | 9606 | 16964285 | ||||
| MAPK1 | DUSP1 | up-regulates | phosphorylation | 9606 | 10617468 | ||||
| JAK2 | JAK2 | up-regulates | phosphorylation | 9606 | 20304997 | ||||
| MAPK1 | SMAD2 | up-regulates | phosphorylation | 9606 | 12193595 | ||||
| MAPK8 | TP53 | up-regulates | phosphorylation | 9606 | 11896587 | ||||
| MAPK1 | EP300 | up-regulates | phosphorylation | 9606 | 17623675 | ||||
| BTK | BTK | up-regulates | phosphorylation | 9606 | 8630736 | ||||
| MAPK1 | STAT5A | up-regulates | phosphorylation | 9606 | 10194762 | ||||
| CTNNB1 | EP300 | up-regulates | binding | 9606 | 10775268 | ||||
| MAPK1 | SREBF1 | up-regulates | phosphorylation | 9606 | 10915800 | ||||
| JAK2 | STAT1 | up-regulates | phosphorylation | 9606 | 15322115 | ||||
| ROCK1 | PTEN | up-regulates | phosphorylation | 9606 | 15793569 | ||||
| AKT1 | DNMT1 | up-regulates | phosphorylation | 9606 | 21151116 | ||||
| MAPK1 | PARP1 | up-regulates | phosphorylation | 9606 | 16627622 | ||||
| MAPK8 | TP53 | up-regulates | phosphorylation | 9606 | 9724739 | ||||
| TNF | AKT1 | up-regulates | 9606 | 11287630 | |||||
| MAPK1 | HIF1A | up-regulates | phosphorylation | 9606 | 18519666 | ||||
| STK11 | TP53 | up-regulates | phosphorylation | 9606 | 17108107 | ||||
| HIPK2 | TP53 | up-regulates | phosphorylation | 9606 | 17210684 | ||||
| PKM | STAT3 | up-regulates | phosphorylation | 9606 | 22306293 | ||||
| AIFM1 | BAX | up-regulates | 9606 | 21210296 | |||||
| PTPN6 | SOCS1 | up-regulates | binding | 9606 | 14551136 |
