Selected Cell
Cell:
Value:
PathwayEnrichmentResults_Top30
PathwayNetwork_Top30
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| id | geneSet | link | size | overlap | expect | enrichmentRatio | pValue | FDR | gene_count | genes |
| Activation of the AP-1 family of transcription factors | R-HSA-450341 | http://reactome.org/PathwayBrowser/#/R-HSA-450341 | 10 | 4 | 0.120344925613569 | 33.2377952755905 | 3.97253159234445E-6 | 8.46645795618411E-5 | 4 | FOS;JUN;MAPK1;MAPK8 |
| CLEC7A/inflammasome pathway | R-HSA-5660668 | http://reactome.org/PathwayBrowser/#/R-HSA-5660668 | 6 | 4 | 0.0722069553681417 | 55.3963254593175 | 2.94578853754501E-7 | 9.13194446638954E-6 | 4 | IL1B;NFKB1;PYCARD;RELA |
| Cross-presentation of particulate exogenous antigens (phagosomes) | R-HSA-1236973 | http://reactome.org/PathwayBrowser/#/R-HSA-1236973 | 8 | 3 | 0.0962759404908556 | 31.1604330708661 | 9.12139446100912E-5 | 0.0010875508780433 | 3 | CYBA;CYBB;NCF1 |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | R-HSA-9027276 | http://reactome.org/PathwayBrowser/#/R-HSA-9027276 | 11 | 4 | 0.132379418174926 | 30.2161775232641 | 6.18443012767588E-6 | 1.21200613421694E-4 | 4 | IRS2;JAK2;PIK3CA;PIK3R1 |
| Erythropoietin activates Phospholipase C gamma (PLCG) | R-HSA-9027277 | http://reactome.org/PathwayBrowser/#/R-HSA-9027277 | 6 | 2 | 0.0722069553681417 | 27.6981627296587 | 0.002088329632218 | 0.0154808783605729 | 2 | IRS2;JAK2 |
| Erythropoietin activates STAT5 | R-HSA-9027283 | http://reactome.org/PathwayBrowser/#/R-HSA-9027283 | 6 | 3 | 0.0722069553681417 | 41.5472440944881 | 3.31573547258656E-5 | 4.79095676335601E-4 | 3 | IRS2;JAK2;STAT5A |
| Growth hormone receptor signaling | R-HSA-982772 | http://reactome.org/PathwayBrowser/#/R-HSA-982772 | 24 | 9 | 0.288827821472567 | 31.1604330708661 | 4.46576109425223E-12 | 5.07608177713336E-10 | 9 | IRS2;JAK2;MAPK1;PTPN6;SOCS1;SOCS3;STAT1;STAT3;STAT5A |
| IRS activation | R-HSA-74713 | http://reactome.org/PathwayBrowser/#/R-HSA-74713 | 5 | 2 | 0.0601724628067848 | 33.2377952755905 | 0.0014032722063873 | 0.0111802762237871 | 2 | INSR;IRS2 |
| IkBA variant leads to EDA-ID | R-HSA-5603029 | http://reactome.org/PathwayBrowser/#/R-HSA-5603029 | 7 | 3 | 0.0842414479294987 | 35.6119235095613 | 5.75146634095302E-5 | 7.66113289947258E-4 | 3 | IKBKB;NFKB1;RELA |
| Inflammasomes | R-HSA-622312 | http://reactome.org/PathwayBrowser/#/R-HSA-622312 | 20 | 6 | 0.240689851227139 | 24.9283464566929 | 9.10921327257341E-8 | 3.52982014312219E-6 | 6 | BCL2;NFKB1;PYCARD;RELA;TXN;TXNIP |
| Interleukin-1 processing | R-HSA-448706 | http://reactome.org/PathwayBrowser/#/R-HSA-448706 | 7 | 3 | 0.0842414479294987 | 35.6119235095613 | 5.75146634095302E-5 | 7.66113289947258E-4 | 3 | IL1B;NFKB1;RELA |
| Interleukin-27 signaling | R-HSA-9020956 | http://reactome.org/PathwayBrowser/#/R-HSA-9020956 | 11 | 4 | 0.132379418174926 | 30.2161775232641 | 6.18443012767588E-6 | 1.21200613421694E-4 | 4 | JAK1;JAK2;STAT1;STAT3 |
| Interleukin-6 signaling | R-HSA-1059683 | http://reactome.org/PathwayBrowser/#/R-HSA-1059683 | 11 | 5 | 0.132379418174926 | 37.7702219040801 | 1.01709155542195E-7 | 3.6226958017906E-6 | 5 | JAK1;JAK2;SOCS3;STAT1;STAT3 |
| Interleukin-9 signaling | R-HSA-8985947 | http://reactome.org/PathwayBrowser/#/R-HSA-8985947 | 9 | 4 | 0.108310433052212 | 36.930883639545 | 2.40592579769938E-6 | 5.61931984257184E-5 | 4 | JAK1;STAT1;STAT3;STAT5A |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | http://reactome.org/PathwayBrowser/#/R-HSA-3134973 | 5 | 3 | 0.0601724628067848 | 49.8566929133858 | 1.672596678981E-5 | 2.79586013496335E-4 | 3 | CTNNB1;EP300;IRF3 |
| Loss of Function of SMAD2/3 in Cancer | R-HSA-3304349 | http://reactome.org/PathwayBrowser/#/R-HSA-3304349 | 7 | 4 | 0.0842414479294987 | 47.482564679415 | 6.80943147646218E-7 | 1.90329191268328E-5 | 4 | SMAD2;SMAD4;TGFB1;TGFBR1 |
| MAPK1 (ERK2) activation | R-HSA-112411 | http://reactome.org/PathwayBrowser/#/R-HSA-112411 | 9 | 3 | 0.108310433052212 | 27.6981627296587 | 1.35617954016398E-4 | 0.0015415240773197 | 3 | JAK1;JAK2;MAPK1 |
| MET activates PI3K/AKT signaling | R-HSA-8851907 | http://reactome.org/PathwayBrowser/#/R-HSA-8851907 | 6 | 2 | 0.0722069553681417 | 27.6981627296587 | 0.002088329632218 | 0.0154808783605729 | 2 | PIK3CA;PIK3R1 |
| NF-kB is activated and signals survival | R-HSA-209560 | http://reactome.org/PathwayBrowser/#/R-HSA-209560 | 13 | 5 | 0.15644840329764 | 31.9594185342216 | 2.77904166123832E-7 | 8.8767826364672E-6 | 5 | IKBKB;IRAK1;NFKB1;RELA;UBC |
| PI3K/AKT activation | R-HSA-198203 | http://reactome.org/PathwayBrowser/#/R-HSA-198203 | 9 | 4 | 0.108310433052212 | 36.930883639545 | 2.40592579769938E-6 | 5.61931984257184E-5 | 4 | IRS2;PIK3CA;PIK3R1;RHOA |
| PTK6 Expression | R-HSA-8849473 | http://reactome.org/PathwayBrowser/#/R-HSA-8849473 | 5 | 2 | 0.0601724628067848 | 33.2377952755905 | 0.0014032722063873 | 0.0111802762237871 | 2 | HIF1A;NR3C1 |
| RHO GTPases Activate NADPH Oxidases | R-HSA-5668599 | http://reactome.org/PathwayBrowser/#/R-HSA-5668599 | 13 | 4 | 0.15644840329764 | 25.5675348273773 | 1.31513723113929E-5 | 2.2423089790925E-4 | 4 | CYBA;CYBB;NCF1;RAC1 |
| RSK activation | R-HSA-444257 | http://reactome.org/PathwayBrowser/#/R-HSA-444257 | 6 | 2 | 0.0722069553681417 | 27.6981627296587 | 0.002088329632218 | 0.0154808783605729 | 2 | MAPK1;RPS6KA3 |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | http://reactome.org/PathwayBrowser/#/R-HSA-8941855 | 7 | 4 | 0.0842414479294987 | 47.482564679415 | 6.80943147646218E-7 | 1.90329191268328E-5 | 4 | CDKN1A;SMAD4;TGFB1;TP53 |
| RUNX3 regulates p14-ARF | R-HSA-8951936 | http://reactome.org/PathwayBrowser/#/R-HSA-8951936 | 9 | 3 | 0.108310433052212 | 27.6981627296587 | 1.35617954016398E-4 | 0.0015415240773197 | 3 | CCND1;EP300;TGFB1 |
| Regulation of IFNG signaling | R-HSA-877312 | http://reactome.org/PathwayBrowser/#/R-HSA-877312 | 14 | 6 | 0.168482895858997 | 35.6119235095613 | 7.48805151218334E-9 | 3.98972744633519E-7 | 6 | JAK1;JAK2;PTPN6;SOCS1;SOCS3;STAT1 |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | http://reactome.org/PathwayBrowser/#/R-HSA-3304356 | 6 | 3 | 0.0722069553681417 | 41.5472440944881 | 3.31573547258656E-5 | 4.79095676335601E-4 | 3 | SMAD2;TGFB1;TGFBR1 |
| Signal attenuation | R-HSA-74749 | http://reactome.org/PathwayBrowser/#/R-HSA-74749 | 10 | 3 | 0.120344925613569 | 24.9283464566929 | 1.92037420769453E-4 | 0.0020592691975592 | 3 | INSR;IRS2;MAPK1 |
| Signaling by Leptin | R-HSA-2586552 | http://reactome.org/PathwayBrowser/#/R-HSA-2586552 | 11 | 5 | 0.132379418174926 | 37.7702219040801 | 1.01709155542195E-7 | 3.6226958017906E-6 | 5 | IRS2;JAK2;SOCS3;STAT3;STAT5A |
| The NLRP3 inflammasome | R-HSA-844456 | http://reactome.org/PathwayBrowser/#/R-HSA-844456 | 15 | 5 | 0.180517388420354 | 27.6981627296587 | 6.36024268363399E-7 | 1.90249364484139E-5 | 5 | NFKB1;PYCARD;RELA;TXN;TXNIP |
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| Note: Edges are drawn between pathways based on their common genes, and the edge width is based on the number of those genes. | |||||||||
