Selected Cell
Cell:
Value:
PathwayEnrichmentResults_Top30
PathwayNetwork_Top30
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| id | geneSet | link | size | overlap | expect | enrichmentRatio | pValue | FDR | gene_count | genes |
| AKT phosphorylates targets in the cytosol | R-HSA-198323 | http://reactome.org/PathwayBrowser/#/R-HSA-198323 | 14 | 5 | 0.126030512650431 | 39.672932330827 | 9.98348947955918E-8 | 1.21584639733202E-5 | 5 | AKT1;AKT1S1;CDKN1A;MDM2;TSC2 |
| AKT phosphorylates targets in the nucleus | R-HSA-198693 | http://reactome.org/PathwayBrowser/#/R-HSA-198693 | 9 | 2 | 0.0810196152752771 | 24.685380116959 | 0.0027705282664296 | 0.0259546741442997 | 2 | AKT1;FOXO1 |
| Activated NTRK3 signals through PI3K | R-HSA-9603381 | http://reactome.org/PathwayBrowser/#/R-HSA-9603381 | 6 | 3 | 0.0540130768501847 | 55.5421052631579 | 1.38616191112106E-5 | 4.37667788603965E-4 | 3 | IRS1;PIK3CA;PIK3R1 |
| Activation of the AP-1 family of transcription factors | R-HSA-450341 | http://reactome.org/PathwayBrowser/#/R-HSA-450341 | 10 | 4 | 0.0900217947503079 | 44.4336842105263 | 1.24179305660554E-6 | 9.20546591961936E-5 | 4 | FOS;JUN;MAPK1;MAPK8 |
| CLEC7A/inflammasome pathway | R-HSA-5660668 | http://reactome.org/PathwayBrowser/#/R-HSA-5660668 | 6 | 2 | 0.0540130768501847 | 37.0280701754386 | 0.0011749087734836 | 0.0134974356854459 | 2 | NFKB1;PYCARD |
| Constitutive Signaling by AKT1 E17K in Cancer | R-HSA-5674400 | http://reactome.org/PathwayBrowser/#/R-HSA-5674400 | 25 | 6 | 0.225054486875769 | 26.6602105263157 | 7.00042592782779E-8 | 9.18132785149722E-6 | 6 | AKT1;AKT1S1;CDKN1A;FOXO1;MDM2;TSC2 |
| EGFR Transactivation by Gastrin | R-HSA-2179392 | http://reactome.org/PathwayBrowser/#/R-HSA-2179392 | 9 | 2 | 0.0810196152752771 | 24.685380116959 | 0.0027705282664296 | 0.0259546741442997 | 2 | EGFR;PRKCA |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | R-HSA-9027276 | http://reactome.org/PathwayBrowser/#/R-HSA-9027276 | 11 | 3 | 0.0990239742253387 | 30.2956937799043 | 1.10673922745885E-4 | 0.0019656149821014 | 3 | IRS2;PIK3CA;PIK3R1 |
| GAB1 signalosome | R-HSA-180292 | http://reactome.org/PathwayBrowser/#/R-HSA-180292 | 11 | 3 | 0.0990239742253387 | 30.2956937799043 | 1.10673922745885E-4 | 0.0019656149821014 | 3 | EGFR;PIK3CA;PIK3R1 |
| Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | http://reactome.org/PathwayBrowser/#/R-HSA-881907 | 18 | 4 | 0.162039230550554 | 24.685380116959 | 1.71214344373282E-5 | 5.12141152906047E-4 | 4 | EGFR;MAPK1;PRKCA;RPS6KA3 |
| Growth hormone receptor signaling | R-HSA-982772 | http://reactome.org/PathwayBrowser/#/R-HSA-982772 | 24 | 6 | 0.216052307400739 | 27.7710526315789 | 5.35903560416883E-8 | 7.61429642092322E-6 | 6 | IRS1;IRS2;MAPK1;SOCS1;SOCS3;STAT1 |
| IRS activation | R-HSA-74713 | http://reactome.org/PathwayBrowser/#/R-HSA-74713 | 5 | 3 | 0.0450108973751539 | 66.6505263157894 | 6.97640403990451E-6 | 2.703356565463E-4 | 3 | INSR;IRS1;IRS2 |
| InlA-mediated entry of Listeria monocytogenes into host cells | R-HSA-8876493 | http://reactome.org/PathwayBrowser/#/R-HSA-8876493 | 9 | 3 | 0.0810196152752771 | 37.0280701754386 | 5.70855961159466E-5 | 0.0011505638051635 | 3 | CDH1;CTNNB1;UBC |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | http://reactome.org/PathwayBrowser/#/R-HSA-3134973 | 5 | 3 | 0.0450108973751539 | 66.6505263157894 | 6.97640403990451E-6 | 2.703356565463E-4 | 3 | CTNNB1;EP300;IRF3 |
| Loss of Function of SMAD2/3 in Cancer | R-HSA-3304349 | http://reactome.org/PathwayBrowser/#/R-HSA-3304349 | 7 | 3 | 0.0630152563252155 | 47.6075187969924 | 2.40993535719491E-5 | 5.95498519422801E-4 | 3 | SMAD2;SMAD4;TGFB1 |
| MET activates PI3K/AKT signaling | R-HSA-8851907 | http://reactome.org/PathwayBrowser/#/R-HSA-8851907 | 6 | 2 | 0.0540130768501847 | 37.0280701754386 | 0.0011749087734836 | 0.0134974356854459 | 2 | PIK3CA;PIK3R1 |
| PI3K/AKT activation | R-HSA-198203 | http://reactome.org/PathwayBrowser/#/R-HSA-198203 | 9 | 4 | 0.0810196152752771 | 49.3707602339181 | 7.50247909131474E-7 | 6.39586342534581E-5 | 4 | IRS1;IRS2;PIK3CA;PIK3R1 |
| PI5P Regulates TP53 Acetylation | R-HSA-6811555 | http://reactome.org/PathwayBrowser/#/R-HSA-6811555 | 9 | 2 | 0.0810196152752771 | 24.685380116959 | 0.0027705282664296 | 0.0259546741442997 | 2 | EP300;TP53 |
| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | R-HSA-8849469 | http://reactome.org/PathwayBrowser/#/R-HSA-8849469 | 9 | 2 | 0.0810196152752771 | 24.685380116959 | 0.0027705282664296 | 0.0259546741442997 | 2 | AKT1;UBC |
| PTK6 promotes HIF1A stabilization | R-HSA-8857538 | http://reactome.org/PathwayBrowser/#/R-HSA-8857538 | 6 | 2 | 0.0540130768501847 | 37.0280701754386 | 0.0011749087734836 | 0.0134974356854459 | 2 | EGFR;HIF1A |
| RSK activation | R-HSA-444257 | http://reactome.org/PathwayBrowser/#/R-HSA-444257 | 6 | 2 | 0.0540130768501847 | 37.0280701754386 | 0.0011749087734836 | 0.0134974356854459 | 2 | MAPK1;RPS6KA3 |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | http://reactome.org/PathwayBrowser/#/R-HSA-8941855 | 7 | 4 | 0.0630152563252155 | 63.4766917293233 | 2.11306497077679E-7 | 2.11927986774966E-5 | 4 | CDKN1A;SMAD4;TGFB1;TP53 |
| RUNX3 regulates p14-ARF | R-HSA-8951936 | http://reactome.org/PathwayBrowser/#/R-HSA-8951936 | 9 | 2 | 0.0810196152752771 | 24.685380116959 | 0.0027705282664296 | 0.0259546741442997 | 2 | EP300;TGFB1 |
| Regulation of PTEN localization | R-HSA-8948747 | http://reactome.org/PathwayBrowser/#/R-HSA-8948747 | 9 | 2 | 0.0810196152752771 | 24.685380116959 | 0.0027705282664296 | 0.0259546741442997 | 2 | PTEN;UBC |
| Regulation of gene expression by Hypoxia-inducible Factor | R-HSA-1234158 | http://reactome.org/PathwayBrowser/#/R-HSA-1234158 | 11 | 3 | 0.0990239742253387 | 30.2956937799043 | 1.10673922745885E-4 | 0.0019656149821014 | 3 | EP300;HIF1A;VEGFA |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | http://reactome.org/PathwayBrowser/#/R-HSA-3304356 | 6 | 2 | 0.0540130768501847 | 37.0280701754386 | 0.0011749087734836 | 0.0134974356854459 | 2 | SMAD2;TGFB1 |
| SOS-mediated signalling | R-HSA-112412 | http://reactome.org/PathwayBrowser/#/R-HSA-112412 | 7 | 2 | 0.0630152563252155 | 31.7383458646616 | 0.0016352325414483 | 0.0171047330255796 | 2 | IRS1;IRS2 |
| Signal attenuation | R-HSA-74749 | http://reactome.org/PathwayBrowser/#/R-HSA-74749 | 10 | 4 | 0.0900217947503079 | 44.4336842105263 | 1.24179305660554E-6 | 9.20546591961936E-5 | 4 | INSR;IRS1;IRS2;MAPK1 |
| Signaling by Leptin | R-HSA-2586552 | http://reactome.org/PathwayBrowser/#/R-HSA-2586552 | 11 | 3 | 0.0990239742253387 | 30.2956937799043 | 1.10673922745885E-4 | 0.0019656149821014 | 3 | IRS1;IRS2;SOCS3 |
| Signaling by NTRK3 (TRKC) | R-HSA-9034015 | http://reactome.org/PathwayBrowser/#/R-HSA-9034015 | 17 | 4 | 0.153037051075523 | 26.1374613003096 | 1.34089507907164E-5 | 4.31363416946633E-4 | 4 | BAX;IRS1;PIK3CA;PIK3R1 |
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| Note: Edges are drawn between pathways based on their common genes, and the edge width is based on the number of those genes. | |||||||||
