Selected Cell
Cell:
Value:
PathwayEnrichmentResults_Top30
PathwayNetwork_Top30
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| id | label | geneSet | link | size | overlap | expect | enrichmentRatio | pValue | FDR | gene_count | genes |
| AKT phosphorylates targets in the cytosol | AKT phosphorylates targets in the cytosol | R-HSA-198323 | http://reactome.org/PathwayBrowser/#/R-HSA-198323 | 14 | 5 | 0.144603430304178 | 34.5773263433813 | 1.99295614011774E-7 | 1.7884159046846E-5 | 5 | AKT1;BAD;CDKN1A;MDM2;TSC2 |
| Activation of BAD and translocation to mitochondria | Activation of BAD and translocation to mitochondria | R-HSA-111447 | http://reactome.org/PathwayBrowser/#/R-HSA-111447 | 15 | 4 | 0.154932246754477 | 25.8177370030581 | 1.34670507404566E-5 | 5.33984221220431E-4 | 4 | AKT1;BAD;BCL2;YWHAZ |
| Activation of the AP-1 family of transcription factors | Activation of the AP-1 family of transcription factors | R-HSA-450341 | http://reactome.org/PathwayBrowser/#/R-HSA-450341 | 10 | 3 | 0.103288164502984 | 29.0449541284403 | 1.2202409531703E-4 | 0.0029302969368385 | 3 | FOS;JUN;MAPK1 |
| Alternative complement activation | Alternative complement activation | R-HSA-173736 | http://reactome.org/PathwayBrowser/#/R-HSA-173736 | 5 | 2 | 0.0516440822514924 | 38.7266055045871 | 0.0010358765275768 | 0.0145964419794921 | 2 | C3;CFB |
| BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | R-HSA-111453 | http://reactome.org/PathwayBrowser/#/R-HSA-111453 | 9 | 3 | 0.0929593480526864 | 32.2721712538226 | 8.6063718384155E-5 | 0.0023291847594441 | 3 | BAD;BCL2;STAT3 |
| Caspase-mediated cleavage of cytoskeletal proteins | Caspase-mediated cleavage of cytoskeletal proteins | R-HSA-264870 | http://reactome.org/PathwayBrowser/#/R-HSA-264870 | 12 | 3 | 0.123945797403581 | 24.2041284403669 | 2.20362868132872E-4 | 0.0044202198843123 | 3 | CASP3;GSN;VIM |
| Constitutive Signaling by EGFRvIII | Constitutive Signaling by EGFRvIII | R-HSA-5637810 | http://reactome.org/PathwayBrowser/#/R-HSA-5637810 | 15 | 5 | 0.154932246754477 | 32.2721712538226 | 2.96490661577664E-7 | 2.29780262722689E-5 | 5 | EGF;EGFR;HSP90AA1;PIK3CA;PIK3R1 |
| EGFR Transactivation by Gastrin | EGFR Transactivation by Gastrin | R-HSA-2179392 | http://reactome.org/PathwayBrowser/#/R-HSA-2179392 | 9 | 2 | 0.0929593480526864 | 21.5147808358817 | 0.0036296731985683 | 0.0355666253078103 | 2 | EGFR;PRKCA |
| GAB1 signalosome | GAB1 signalosome | R-HSA-180292 | http://reactome.org/PathwayBrowser/#/R-HSA-180292 | 11 | 4 | 0.113616980953283 | 35.2060050041701 | 3.36133201506161E-6 | 1.91035702856001E-4 | 4 | EGF;EGFR;PIK3CA;PIK3R1 |
| GRB2 events in EGFR signaling | GRB2 events in EGFR signaling | R-HSA-179812 | http://reactome.org/PathwayBrowser/#/R-HSA-179812 | 7 | 2 | 0.0723017151520894 | 27.6618610747051 | 0.0021461059448024 | 0.0248020266245013 | 2 | EGF;EGFR |
| Gastrin-CREB signalling pathway via PKC and MAPK | Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | http://reactome.org/PathwayBrowser/#/R-HSA-881907 | 18 | 4 | 0.185918696105372 | 21.5147808358817 | 2.94766181279104E-5 | 9.56463115917184E-4 | 4 | EGFR;MAPK1;PRKCA;RPS6KA3 |
| Growth hormone receptor signaling | Growth hormone receptor signaling | R-HSA-982772 | http://reactome.org/PathwayBrowser/#/R-HSA-982772 | 24 | 5 | 0.247891594807163 | 20.1701070336391 | 3.89681476009595E-6 | 2.14324811805277E-4 | 5 | MAPK1;SOCS2;SOCS3;STAT1;STAT3 |
| Interleukin-6 signaling | Interleukin-6 signaling | R-HSA-1059683 | http://reactome.org/PathwayBrowser/#/R-HSA-1059683 | 11 | 4 | 0.113616980953283 | 35.2060050041701 | 3.36133201506161E-6 | 1.91035702856001E-4 | 4 | JAK1;SOCS3;STAT1;STAT3 |
| Interleukin-9 signaling | Interleukin-9 signaling | R-HSA-8985947 | http://reactome.org/PathwayBrowser/#/R-HSA-8985947 | 9 | 3 | 0.0929593480526864 | 32.2721712538226 | 8.6063718384155E-5 | 0.0023291847594441 | 3 | JAK1;STAT1;STAT3 |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | http://reactome.org/PathwayBrowser/#/R-HSA-3134973 | 5 | 3 | 0.0516440822514924 | 58.0899082568807 | 1.05599297750558E-5 | 4.39138543084638E-4 | 3 | CTNNB1;EP300;IRF3 |
| MAPK1 (ERK2) activation | MAPK1 (ERK2) activation | R-HSA-112411 | http://reactome.org/PathwayBrowser/#/R-HSA-112411 | 9 | 2 | 0.0929593480526864 | 21.5147808358817 | 0.0036296731985683 | 0.0355666253078103 | 2 | JAK1;MAPK1 |
| MET activates PI3K/AKT signaling | MET activates PI3K/AKT signaling | R-HSA-8851907 | http://reactome.org/PathwayBrowser/#/R-HSA-8851907 | 6 | 2 | 0.0619728987017909 | 32.2721712538226 | 0.0015433343678142 | 0.0192071904899515 | 2 | PIK3CA;PIK3R1 |
| PI3K/AKT activation | PI3K/AKT activation | R-HSA-198203 | http://reactome.org/PathwayBrowser/#/R-HSA-198203 | 9 | 3 | 0.0929593480526864 | 32.2721712538226 | 8.6063718384155E-5 | 0.0023291847594441 | 3 | PIK3CA;PIK3R1;RHOA |
| PTK6 Expression | PTK6 Expression | R-HSA-8849473 | http://reactome.org/PathwayBrowser/#/R-HSA-8849473 | 5 | 2 | 0.0516440822514924 | 38.7266055045871 | 0.0010358765275768 | 0.0145964419794921 | 2 | HIF1A;NR3C1 |
| PTK6 promotes HIF1A stabilization | PTK6 promotes HIF1A stabilization | R-HSA-8857538 | http://reactome.org/PathwayBrowser/#/R-HSA-8857538 | 6 | 2 | 0.0619728987017909 | 32.2721712538226 | 0.0015433343678142 | 0.0192071904899515 | 2 | EGFR;HIF1A |
| RHO GTPases activate KTN1 | RHO GTPases activate KTN1 | R-HSA-5625970 | http://reactome.org/PathwayBrowser/#/R-HSA-5625970 | 11 | 3 | 0.113616980953283 | 26.4045037531276 | 1.66522631555254E-4 | 0.0036400139333552 | 3 | KTN1;RAC1;RHOA |
| RSK activation | RSK activation | R-HSA-444257 | http://reactome.org/PathwayBrowser/#/R-HSA-444257 | 6 | 2 | 0.0619728987017909 | 32.2721712538226 | 0.0015433343678142 | 0.0192071904899515 | 2 | MAPK1;RPS6KA3 |
| RUNX3 regulates CDKN1A transcription | RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | http://reactome.org/PathwayBrowser/#/R-HSA-8941855 | 7 | 2 | 0.0723017151520894 | 27.6618610747051 | 0.0021461059448024 | 0.0248020266245013 | 2 | CDKN1A;SMAD4 |
| RUNX3 regulates WNT signaling | RUNX3 regulates WNT signaling | R-HSA-8951430 | http://reactome.org/PathwayBrowser/#/R-HSA-8951430 | 8 | 2 | 0.0826305316023879 | 24.2041284403669 | 0.0028422044251941 | 0.0308659779933501 | 2 | CCND1;CTNNB1 |
| RUNX3 regulates p14-ARF | RUNX3 regulates p14-ARF | R-HSA-8951936 | http://reactome.org/PathwayBrowser/#/R-HSA-8951936 | 9 | 2 | 0.0929593480526864 | 21.5147808358817 | 0.0036296731985683 | 0.0355666253078103 | 2 | CCND1;EP300 |
| Regulation of IFNG signaling | Regulation of IFNG signaling | R-HSA-877312 | http://reactome.org/PathwayBrowser/#/R-HSA-877312 | 14 | 3 | 0.144603430304178 | 20.7463958060288 | 3.59148694269562E-4 | 0.0062484543237714 | 3 | JAK1;SOCS3;STAT1 |
| Regulation of gene expression by Hypoxia-inducible Factor | Regulation of gene expression by Hypoxia-inducible Factor | R-HSA-1234158 | http://reactome.org/PathwayBrowser/#/R-HSA-1234158 | 11 | 3 | 0.113616980953283 | 26.4045037531276 | 1.66522631555254E-4 | 0.0036400139333552 | 3 | EP300;HIF1A;VEGFA |
| Sema4D mediated inhibition of cell attachment and migration | Sema4D mediated inhibition of cell attachment and migration | R-HSA-416550 | http://reactome.org/PathwayBrowser/#/R-HSA-416550 | 8 | 2 | 0.0826305316023879 | 24.2041284403669 | 0.0028422044251941 | 0.0308659779933501 | 2 | RAC1;RHOA |
| Signaling by cytosolic FGFR1 fusion mutants | Signaling by cytosolic FGFR1 fusion mutants | R-HSA-1839117 | http://reactome.org/PathwayBrowser/#/R-HSA-1839117 | 18 | 4 | 0.185918696105372 | 21.5147808358817 | 2.94766181279104E-5 | 9.56463115917184E-4 | 4 | PIK3CA;PIK3R1;STAT1;STAT3 |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | R-HSA-1474151 | http://reactome.org/PathwayBrowser/#/R-HSA-1474151 | 12 | 3 | 0.123945797403581 | 24.2041284403669 | 2.20362868132872E-4 | 0.0044202198843123 | 3 | AKT1;CALM1;HSP90AA1 |
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| Note: Edges are drawn between pathways based on their common genes, and the edge width is based on the number of those genes. | |||||||||
