Selected Cell
Cell:
Value:
PathwayEnrichmentResults_Top30
PathwayNetwork_Top30
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| id | geneSet | link | size | overlap | expect | enrichmentRatio | pValue | FDR | gene_count | genes |
| Activated NTRK3 signals through PI3K | R-HSA-9603381 | http://reactome.org/PathwayBrowser/#/R-HSA-9603381 | 6 | 2 | 0.0602672225907324 | 33.1855345911949 | 0.0014602783080175 | 0.014227282943828 | 2 | IRS1;PIK3R1 |
| Activation of the AP-1 family of transcription factors | R-HSA-450341 | http://reactome.org/PathwayBrowser/#/R-HSA-450341 | 10 | 4 | 0.100445370984554 | 39.8226415094339 | 1.92799509690644E-6 | 5.76707305302716E-5 | 4 | FOS;JUN;MAPK1;MAPK8 |
| Constitutive Signaling by EGFRvIII | R-HSA-5637810 | http://reactome.org/PathwayBrowser/#/R-HSA-5637810 | 15 | 4 | 0.150668056476831 | 26.5484276729559 | 1.20556479734634E-5 | 2.70458944667832E-4 | 4 | EGF;EGFR;HSP90AA1;PIK3R1 |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | R-HSA-1236382 | http://reactome.org/PathwayBrowser/#/R-HSA-1236382 | 19 | 5 | 0.190846204870652 | 26.1991062562065 | 9.66808290314702E-7 | 3.05260765738253E-5 | 5 | EGF;EGFR;HSP90AA1;PIK3R1;UBC |
| DSCAM interactions | R-HSA-376172 | http://reactome.org/PathwayBrowser/#/R-HSA-376172 | 11 | 3 | 0.110489908083009 | 27.1518010291595 | 1.53289291490166E-4 | 0.0023545787566732 | 3 | MAPK12;MAPK8;RAC1 |
| Downregulation of TGF-beta receptor signaling | R-HSA-2173788 | http://reactome.org/PathwayBrowser/#/R-HSA-2173788 | 26 | 6 | 0.26115796455984 | 22.9746008708272 | 1.74178288903092E-7 | 7.24326786779935E-6 | 6 | SMAD2;SMAD3;SMAD7;TGFB1;TGFBR1;UBC |
| GAB1 signalosome | R-HSA-180292 | http://reactome.org/PathwayBrowser/#/R-HSA-180292 | 11 | 3 | 0.110489908083009 | 27.1518010291595 | 1.53289291490166E-4 | 0.0023545787566732 | 3 | EGF;EGFR;PIK3R1 |
| GRB2 events in EGFR signaling | R-HSA-179812 | http://reactome.org/PathwayBrowser/#/R-HSA-179812 | 7 | 2 | 0.0703117596891879 | 28.4447439353099 | 0.0020309961549394 | 0.0184194066179344 | 2 | EGF;EGFR |
| Growth hormone receptor signaling | R-HSA-982772 | http://reactome.org/PathwayBrowser/#/R-HSA-982772 | 24 | 7 | 0.241068890362929 | 29.0373427672956 | 2.5401294401206E-9 | 2.70682543462852E-7 | 7 | IRS1;MAPK1;SOCS1;SOCS3;STAT1;STAT3;STAT5A |
| IRS activation | R-HSA-74713 | http://reactome.org/PathwayBrowser/#/R-HSA-74713 | 5 | 2 | 0.050222685492277 | 39.8226415094339 | 9.79943703379282E-4 | 0.0104366832164337 | 2 | INSR;IRS1 |
| IkBA variant leads to EDA-ID | R-HSA-5603029 | http://reactome.org/PathwayBrowser/#/R-HSA-5603029 | 7 | 2 | 0.0703117596891879 | 28.4447439353099 | 0.0020309961549394 | 0.0184194066179344 | 2 | IKBKB;RELA |
| InlA-mediated entry of Listeria monocytogenes into host cells | R-HSA-8876493 | http://reactome.org/PathwayBrowser/#/R-HSA-8876493 | 9 | 3 | 0.0904008338860987 | 33.1855345911949 | 7.91905143604498E-5 | 0.0013501982698456 | 3 | CDH1;CTNNB1;UBC |
| Interleukin-6 signaling | R-HSA-1059683 | http://reactome.org/PathwayBrowser/#/R-HSA-1059683 | 11 | 4 | 0.110489908083009 | 36.2024013722126 | 3.00630561900216E-6 | 8.68771369559101E-5 | 4 | IL6;SOCS3;STAT1;STAT3 |
| Interleukin-9 signaling | R-HSA-8985947 | http://reactome.org/PathwayBrowser/#/R-HSA-8985947 | 9 | 3 | 0.0904008338860987 | 33.1855345911949 | 7.91905143604498E-5 | 0.0013501982698456 | 3 | STAT1;STAT3;STAT5A |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | http://reactome.org/PathwayBrowser/#/R-HSA-3134973 | 5 | 2 | 0.050222685492277 | 39.8226415094339 | 9.79943703379282E-4 | 0.0104366832164337 | 2 | CTNNB1;EP300 |
| Loss of Function of SMAD2/3 in Cancer | R-HSA-3304349 | http://reactome.org/PathwayBrowser/#/R-HSA-3304349 | 7 | 5 | 0.0703117596891879 | 71.1118598382749 | 1.92202487259152E-9 | 2.70682543462852E-7 | 5 | SMAD2;SMAD3;SMAD4;TGFB1;TGFBR1 |
| NF-kB is activated and signals survival | R-HSA-209560 | http://reactome.org/PathwayBrowser/#/R-HSA-209560 | 13 | 3 | 0.13057898227992 | 22.9746008708272 | 2.61838389088664E-4 | 0.0036295484015949 | 3 | IKBKB;RELA;UBC |
| PI3K/AKT activation | R-HSA-198203 | http://reactome.org/PathwayBrowser/#/R-HSA-198203 | 9 | 3 | 0.0904008338860987 | 33.1855345911949 | 7.91905143604498E-5 | 0.0013501982698456 | 3 | IRS1;PIK3R1;RHOA |
| RHO GTPases activate KTN1 | R-HSA-5625970 | http://reactome.org/PathwayBrowser/#/R-HSA-5625970 | 11 | 3 | 0.110489908083009 | 27.1518010291595 | 1.53289291490166E-4 | 0.0023545787566732 | 3 | KTN1;RAC1;RHOA |
| RORA activates gene expression | R-HSA-1368082 | http://reactome.org/PathwayBrowser/#/R-HSA-1368082 | 18 | 5 | 0.180801667772197 | 27.6546121593291 | 7.18103811303549E-7 | 2.4487339965451E-5 | 5 | CPT1A;EP300;PPARA;RORA;SREBF1 |
| RSK activation | R-HSA-444257 | http://reactome.org/PathwayBrowser/#/R-HSA-444257 | 6 | 2 | 0.0602672225907324 | 33.1855345911949 | 0.0014602783080175 | 0.014227282943828 | 2 | MAPK1;RPS6KA3 |
| RUNX3 regulates BCL2L11 (BIM) transcription | R-HSA-8952158 | http://reactome.org/PathwayBrowser/#/R-HSA-8952158 | 5 | 2 | 0.050222685492277 | 39.8226415094339 | 9.79943703379282E-4 | 0.0104366832164337 | 2 | SMAD3;SMAD4 |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | http://reactome.org/PathwayBrowser/#/R-HSA-8941855 | 7 | 5 | 0.0703117596891879 | 71.1118598382749 | 1.92202487259152E-9 | 2.70682543462852E-7 | 5 | CDKN1A;SMAD3;SMAD4;TGFB1;TP53 |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | http://reactome.org/PathwayBrowser/#/R-HSA-3304356 | 6 | 4 | 0.0602672225907324 | 66.3710691823899 | 1.42054852436679E-7 | 6.54604117309563E-6 | 4 | SMAD2;SMAD3;TGFB1;TGFBR1 |
| Sema4D mediated inhibition of cell attachment and migration | R-HSA-416550 | http://reactome.org/PathwayBrowser/#/R-HSA-416550 | 8 | 2 | 0.0803562967876433 | 24.8891509433962 | 0.0026902674474185 | 0.0227121849768456 | 2 | RAC1;RHOA |
| Signal attenuation | R-HSA-74749 | http://reactome.org/PathwayBrowser/#/R-HSA-74749 | 10 | 3 | 0.100445370984554 | 29.8669811320754 | 1.12303022616222E-4 | 0.0018063835241571 | 3 | INSR;IRS1;MAPK1 |
| Signaling by Activin | R-HSA-1502540 | http://reactome.org/PathwayBrowser/#/R-HSA-1502540 | 13 | 3 | 0.13057898227992 | 22.9746008708272 | 2.61838389088664E-4 | 0.0036295484015949 | 3 | SMAD2;SMAD3;SMAD4 |
| Signaling by Leptin | R-HSA-2586552 | http://reactome.org/PathwayBrowser/#/R-HSA-2586552 | 11 | 5 | 0.110489908083009 | 45.2530017152658 | 4.09516832666767E-8 | 2.25234257966722E-6 | 5 | IRS1;LEPR;SOCS3;STAT3;STAT5A |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | R-HSA-2173791 | http://reactome.org/PathwayBrowser/#/R-HSA-2173791 | 16 | 5 | 0.160712593575286 | 31.1114386792452 | 3.71994809400533E-7 | 1.34947053197427E-5 | 5 | PRKCZ;RHOA;TGFB1;TGFBR1;UBC |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | R-HSA-1474151 | http://reactome.org/PathwayBrowser/#/R-HSA-1474151 | 12 | 3 | 0.120534445181464 | 24.8891509433962 | 2.0289417637942E-4 | 0.0030081267019731 | 3 | CALM1;HSP90AA1;NOS3 |
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| Note: Edges are drawn between pathways based on their common genes, and the edge width is based on the number of those genes. | |||||||||
