Selected Cell
Cell:
Value:
PathwayEnrichmentResults_Top30
PathwayNetwork_Top30
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| id | geneSet | link | size | overlap | expect | enrichmentRatio | pValue | FDR | gene_count | genes |
| AKT phosphorylates targets in the cytosol | R-HSA-198323 | http://reactome.org/PathwayBrowser/#/R-HSA-198323 | 14 | 4 | 0.131337060551501 | 30.4559884559884 | 6.787526540597E-6 | 2.06655941994962E-4 | 4 | BAD;CDKN1A;MDM2;TSC2 |
| Activation of the AP-1 family of transcription factors | R-HSA-450341 | http://reactome.org/PathwayBrowser/#/R-HSA-450341 | 10 | 3 | 0.0938121861082156 | 31.9787878787878 | 9.16253201811434E-5 | 0.0016797975366542 | 3 | FOS;JUN;MAPK1 |
| Constitutive Signaling by EGFRvIII | R-HSA-5637810 | http://reactome.org/PathwayBrowser/#/R-HSA-5637810 | 15 | 4 | 0.140718279162323 | 28.4255892255892 | 9.18918621040099E-6 | 2.65551906588706E-4 | 4 | EGFR;HSP90AA1;PIK3CA;PIK3R1 |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | R-HSA-1236382 | http://reactome.org/PathwayBrowser/#/R-HSA-1236382 | 19 | 5 | 0.178243153605609 | 28.0515683147262 | 6.87674197807908E-7 | 3.25690140906245E-5 | 5 | EGFR;HSP90AA1;PIK3CA;PIK3R1;UBC |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | R-HSA-2173795 | http://reactome.org/PathwayBrowser/#/R-HSA-2173795 | 23 | 6 | 0.215768028048896 | 27.8076416337285 | 5.1907830700415E-8 | 5.20605007907103E-6 | 6 | HDAC1;PARP1;SMAD2;SMAD3;SMAD4;UBC |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | R-HSA-9027276 | http://reactome.org/PathwayBrowser/#/R-HSA-9027276 | 11 | 3 | 0.103193404719037 | 29.0716253443526 | 1.25127330950602E-4 | 0.0021334209927077 | 3 | JAK2;PIK3CA;PIK3R1 |
| GAB1 signalosome | R-HSA-180292 | http://reactome.org/PathwayBrowser/#/R-HSA-180292 | 11 | 3 | 0.103193404719037 | 29.0716253443526 | 1.25127330950602E-4 | 0.0021334209927077 | 3 | EGFR;PIK3CA;PIK3R1 |
| InlA-mediated entry of Listeria monocytogenes into host cells | R-HSA-8876493 | http://reactome.org/PathwayBrowser/#/R-HSA-8876493 | 9 | 2 | 0.0844309674973941 | 23.6879910213243 | 0.003004711501966 | 0.0224694434686493 | 2 | CTNNB1;UBC |
| Interleukin-27 signaling | R-HSA-9020956 | http://reactome.org/PathwayBrowser/#/R-HSA-9020956 | 11 | 3 | 0.103193404719037 | 29.0716253443526 | 1.25127330950602E-4 | 0.0021334209927077 | 3 | JAK1;JAK2;STAT1 |
| Interleukin-6 signaling | R-HSA-1059683 | http://reactome.org/PathwayBrowser/#/R-HSA-1059683 | 11 | 4 | 0.103193404719037 | 38.7621671258034 | 2.28662479617725E-6 | 9.99665455764669E-5 | 4 | JAK1;JAK2;SOCS3;STAT1 |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | http://reactome.org/PathwayBrowser/#/R-HSA-3134973 | 5 | 3 | 0.0469060930541078 | 63.9575757575757 | 7.9009928921625E-6 | 2.36336717212931E-4 | 3 | CTNNB1;EP300;IRF3 |
| Loss of Function of SMAD2/3 in Cancer | R-HSA-3304349 | http://reactome.org/PathwayBrowser/#/R-HSA-3304349 | 7 | 4 | 0.0656685302757509 | 60.9119769119769 | 2.49630143889234E-7 | 1.85051911013541E-5 | 4 | SMAD2;SMAD3;SMAD4;TGFBR1 |
| MAPK1 (ERK2) activation | R-HSA-112411 | http://reactome.org/PathwayBrowser/#/R-HSA-112411 | 9 | 3 | 0.0844309674973941 | 35.5319865319865 | 6.45774251267772E-5 | 0.0012953471746018 | 3 | JAK1;JAK2;MAPK1 |
| MET activates PI3K/AKT signaling | R-HSA-8851907 | http://reactome.org/PathwayBrowser/#/R-HSA-8851907 | 6 | 2 | 0.0562873116649294 | 35.5319865319865 | 0.0012751850485552 | 0.0110928087131977 | 2 | PIK3CA;PIK3R1 |
| NTRK2 activates RAC1 | R-HSA-9032759 | http://reactome.org/PathwayBrowser/#/R-HSA-9032759 | 5 | 2 | 0.0469060930541078 | 42.6383838383838 | 8.55354774179417E-4 | 0.0080130763185489 | 2 | FYN;RAC1 |
| PI3K/AKT activation | R-HSA-198203 | http://reactome.org/PathwayBrowser/#/R-HSA-198203 | 9 | 3 | 0.0844309674973941 | 35.5319865319865 | 6.45774251267772E-5 | 0.0012953471746018 | 3 | PIK3CA;PIK3R1;RHOA |
| PI5P Regulates TP53 Acetylation | R-HSA-6811555 | http://reactome.org/PathwayBrowser/#/R-HSA-6811555 | 9 | 2 | 0.0844309674973941 | 23.6879910213243 | 0.003004711501966 | 0.0224694434686493 | 2 | EP300;TP53 |
| RSK activation | R-HSA-444257 | http://reactome.org/PathwayBrowser/#/R-HSA-444257 | 6 | 2 | 0.0562873116649294 | 35.5319865319865 | 0.0012751850485552 | 0.0110928087131977 | 2 | MAPK1;RPS6KA3 |
| RUNX3 regulates BCL2L11 (BIM) transcription | R-HSA-8952158 | http://reactome.org/PathwayBrowser/#/R-HSA-8952158 | 5 | 2 | 0.0469060930541078 | 42.6383838383838 | 8.55354774179417E-4 | 0.0080130763185489 | 2 | SMAD3;SMAD4 |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | http://reactome.org/PathwayBrowser/#/R-HSA-8941855 | 7 | 4 | 0.0656685302757509 | 60.9119769119769 | 2.49630143889234E-7 | 1.85051911013541E-5 | 4 | CDKN1A;SMAD3;SMAD4;TP53 |
| Regulation of IFNG signaling | R-HSA-877312 | http://reactome.org/PathwayBrowser/#/R-HSA-877312 | 14 | 5 | 0.131337060551501 | 38.0699855699855 | 1.22886463560512E-7 | 1.13215955628649E-5 | 5 | JAK1;JAK2;PTPN6;SOCS3;STAT1 |
| Regulation of PTEN localization | R-HSA-8948747 | http://reactome.org/PathwayBrowser/#/R-HSA-8948747 | 9 | 2 | 0.0844309674973941 | 23.6879910213243 | 0.003004711501966 | 0.0224694434686493 | 2 | PTEN;UBC |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | http://reactome.org/PathwayBrowser/#/R-HSA-3304356 | 6 | 3 | 0.0562873116649294 | 53.2979797979798 | 1.5694225427687E-5 | 4.18103974284475E-4 | 3 | SMAD2;SMAD3;TGFBR1 |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | R-HSA-2173796 | http://reactome.org/PathwayBrowser/#/R-HSA-2173796 | 32 | 8 | 0.30019899554629 | 26.6489898989899 | 3.93429400169509E-10 | 5.58997606074177E-8 | 8 | HDAC1;JUNB;SMAD2;SMAD3;SMAD4;SMAD7;SP1;UBC |
| Sema4D mediated inhibition of cell attachment and migration | R-HSA-416550 | http://reactome.org/PathwayBrowser/#/R-HSA-416550 | 8 | 2 | 0.0750497488865725 | 26.6489898989899 | 0.0023513483737795 | 0.0184748800796968 | 2 | RAC1;RHOA |
| Signaling by Activin | R-HSA-1502540 | http://reactome.org/PathwayBrowser/#/R-HSA-1502540 | 13 | 3 | 0.12195584194068 | 24.5990675990676 | 2.13946755602267E-4 | 0.0028756417660642 | 3 | SMAD2;SMAD3;SMAD4 |
| Signaling by Leptin | R-HSA-2586552 | http://reactome.org/PathwayBrowser/#/R-HSA-2586552 | 11 | 3 | 0.103193404719037 | 29.0716253443526 | 1.25127330950602E-4 | 0.0021334209927077 | 3 | JAK2;LEPR;SOCS3 |
| TICAM1-dependent activation of IRF3/IRF7 | R-HSA-9013973 | http://reactome.org/PathwayBrowser/#/R-HSA-9013973 | 12 | 3 | 0.112574623329858 | 26.6489898989899 | 1.65701352846658E-4 | 0.0025187358680362 | 3 | IRF3;TLR3;UBC |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | R-HSA-1474151 | http://reactome.org/PathwayBrowser/#/R-HSA-1474151 | 12 | 3 | 0.112574623329858 | 26.6489898989899 | 1.65701352846658E-4 | 0.0025187358680362 | 3 | CALM1;HSP90AA1;NOS3 |
| VEGF ligand-receptor interactions | R-HSA-194313 | http://reactome.org/PathwayBrowser/#/R-HSA-194313 | 8 | 2 | 0.0750497488865725 | 26.6489898989899 | 0.0023513483737795 | 0.0184748800796968 | 2 | KDR;VEGFA |
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| Note: Edges are drawn between pathways based on their common genes, and the edge width is based on the number of those genes. | |||||||||
