Selected Cell
Cell:
Value:
PathwayEnrichmentResults_Top30
PathwayNetwork_Top30
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| id | geneSet | link | size | overlap | expect | enrichmentRatio | pValue | FDR | gene_count | genes |
| AKT phosphorylates targets in the cytosol | R-HSA-198323 | http://reactome.org/PathwayBrowser/#/R-HSA-198323 | 14 | 4 | 0.128683786600966 | 31.0839469808542 | 6.25696306855161E-6 | 2.88327622483256E-4 | 4 | AKT1;AKT1S1;CDKN1A;MDM2 |
| Activated NTRK3 signals through PI3K | R-HSA-9603381 | http://reactome.org/PathwayBrowser/#/R-HSA-9603381 | 6 | 2 | 0.0551501942575571 | 36.2646048109965 | 0.0012245465266206 | 0.0164006787503442 | 2 | PIK3R1;SRC |
| Activation of BAD and translocation to mitochondria | R-HSA-111447 | http://reactome.org/PathwayBrowser/#/R-HSA-111447 | 15 | 3 | 0.137875485643892 | 21.7587628865979 | 3.16157346609502E-4 | 0.0052847870193058 | 3 | AKT1;YWHAB;YWHAZ |
| Apoptotic cleavage of cell adhesion proteins | R-HSA-351906 | http://reactome.org/PathwayBrowser/#/R-HSA-351906 | 11 | 3 | 0.101108689472188 | 29.6710402999062 | 1.17755615583581E-4 | 0.0026417542706579 | 3 | CASP3;CDH1;CTNNB1 |
| Caspase-mediated cleavage of cytoskeletal proteins | R-HSA-264870 | http://reactome.org/PathwayBrowser/#/R-HSA-264870 | 12 | 3 | 0.110300388515114 | 27.1984536082474 | 1.55961444164853E-4 | 0.0031656459797747 | 3 | CASP3;GSN;VIM |
| Constitutive Signaling by EGFRvIII | R-HSA-5637810 | http://reactome.org/PathwayBrowser/#/R-HSA-5637810 | 15 | 4 | 0.137875485643892 | 29.0116838487972 | 8.47217844879288E-6 | 3.70386262953637E-4 | 4 | EGF;EGFR;HSP90AA1;PIK3R1 |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | R-HSA-1236382 | http://reactome.org/PathwayBrowser/#/R-HSA-1236382 | 19 | 5 | 0.174642281815597 | 28.6299511665762 | 6.21008985790538E-7 | 4.23528128309147E-5 | 5 | EGF;EGFR;HSP90AA1;PIK3R1;UBC |
| ERBB2 Regulates Cell Motility | R-HSA-6785631 | http://reactome.org/PathwayBrowser/#/R-HSA-6785631 | 15 | 3 | 0.137875485643892 | 21.7587628865979 | 3.16157346609502E-4 | 0.0052847870193058 | 3 | EGF;EGFR;RHOA |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | R-HSA-9027276 | http://reactome.org/PathwayBrowser/#/R-HSA-9027276 | 11 | 2 | 0.101108689472188 | 19.7806935332708 | 0.0043573960882568 | 0.0395178740982864 | 2 | JAK2;PIK3R1 |
| Formation of annular gap junctions | R-HSA-196025 | http://reactome.org/PathwayBrowser/#/R-HSA-196025 | 11 | 2 | 0.101108689472188 | 19.7806935332708 | 0.0043573960882568 | 0.0395178740982864 | 2 | ACTB;CLTC |
| GAB1 signalosome | R-HSA-180292 | http://reactome.org/PathwayBrowser/#/R-HSA-180292 | 11 | 4 | 0.101108689472188 | 39.5613870665417 | 2.10692351698682E-6 | 1.28296592730804E-4 | 4 | EGF;EGFR;PIK3R1;SRC |
| GP1b-IX-V activation signalling | R-HSA-430116 | http://reactome.org/PathwayBrowser/#/R-HSA-430116 | 12 | 4 | 0.110300388515114 | 36.2646048109965 | 3.13812983976369E-6 | 1.67668367272045E-4 | 4 | COL1A2;PIK3R1;SRC;YWHAZ |
| GRB2 events in EGFR signaling | R-HSA-179812 | http://reactome.org/PathwayBrowser/#/R-HSA-179812 | 7 | 2 | 0.0643418933004832 | 31.0839469808542 | 0.0017041027306261 | 0.020318147942081 | 2 | EGF;EGFR |
| InlA-mediated entry of Listeria monocytogenes into host cells | R-HSA-8876493 | http://reactome.org/PathwayBrowser/#/R-HSA-8876493 | 9 | 4 | 0.0827252913863356 | 48.352806414662 | 8.15916388785531E-7 | 5.35052862645896E-5 | 4 | CDH1;CTNNB1;SRC;UBC |
| Interleukin-27 signaling | R-HSA-9020956 | http://reactome.org/PathwayBrowser/#/R-HSA-9020956 | 11 | 3 | 0.101108689472188 | 29.6710402999062 | 1.17755615583581E-4 | 0.0026417542706579 | 3 | JAK1;JAK2;STAT1 |
| Interleukin-9 signaling | R-HSA-8985947 | http://reactome.org/PathwayBrowser/#/R-HSA-8985947 | 9 | 2 | 0.0827252913863356 | 24.176403207331 | 0.0028864849054024 | 0.0289497456688892 | 2 | JAK1;STAT1 |
| Loss of Function of SMAD2/3 in Cancer | R-HSA-3304349 | http://reactome.org/PathwayBrowser/#/R-HSA-3304349 | 7 | 4 | 0.0643418933004832 | 62.1678939617084 | 2.29872036183742E-7 | 1.93584280743548E-5 | 4 | SMAD2;SMAD4;TGFB1;TGFBR1 |
| MAPK1 (ERK2) activation | R-HSA-112411 | http://reactome.org/PathwayBrowser/#/R-HSA-112411 | 9 | 2 | 0.0827252913863356 | 24.176403207331 | 0.0028864849054024 | 0.0289497456688892 | 2 | JAK1;JAK2 |
| PI3K events in ERBB2 signaling | R-HSA-1963642 | http://reactome.org/PathwayBrowser/#/R-HSA-1963642 | 16 | 3 | 0.147067184686818 | 20.3988402061855 | 3.86528251093087E-4 | 0.0063877605974641 | 3 | EGF;EGFR;PIK3R1 |
| PI3K/AKT activation | R-HSA-198203 | http://reactome.org/PathwayBrowser/#/R-HSA-198203 | 9 | 2 | 0.0827252913863356 | 24.176403207331 | 0.0028864849054024 | 0.0289497456688892 | 2 | PIK3R1;RHOA |
| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | R-HSA-8849469 | http://reactome.org/PathwayBrowser/#/R-HSA-8849469 | 9 | 2 | 0.0827252913863356 | 24.176403207331 | 0.0028864849054024 | 0.0289497456688892 | 2 | AKT1;UBC |
| Pink/Parkin Mediated Mitophagy | R-HSA-5205685 | http://reactome.org/PathwayBrowser/#/R-HSA-5205685 | 22 | 4 | 0.202217378944376 | 19.7806935332708 | 4.32142132422708E-5 | 0.0012488175182724 | 4 | MFN1;MFN2;PINK1;UBC |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | http://reactome.org/PathwayBrowser/#/R-HSA-8941855 | 7 | 4 | 0.0643418933004832 | 62.1678939617084 | 2.29872036183742E-7 | 1.93584280743548E-5 | 4 | CDKN1A;SMAD4;TGFB1;TP53 |
| Regulation of IFNG signaling | R-HSA-877312 | http://reactome.org/PathwayBrowser/#/R-HSA-877312 | 14 | 4 | 0.128683786600966 | 31.0839469808542 | 6.25696306855161E-6 | 2.88327622483256E-4 | 4 | JAK1;JAK2;SOCS1;STAT1 |
| Regulation of PTEN localization | R-HSA-8948747 | http://reactome.org/PathwayBrowser/#/R-HSA-8948747 | 9 | 2 | 0.0827252913863356 | 24.176403207331 | 0.0028864849054024 | 0.0289497456688892 | 2 | PTEN;UBC |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | http://reactome.org/PathwayBrowser/#/R-HSA-3304356 | 6 | 3 | 0.0551501942575571 | 54.3969072164948 | 1.47590975051459E-5 | 5.47049157527691E-4 | 3 | SMAD2;TGFB1;TGFBR1 |
| Sema4D mediated inhibition of cell attachment and migration | R-HSA-416550 | http://reactome.org/PathwayBrowser/#/R-HSA-416550 | 8 | 2 | 0.0735335923434094 | 27.1984536082474 | 0.0022585450660523 | 0.0242189895447755 | 2 | RHOA;RRAS |
| Signaling by Leptin | R-HSA-2586552 | http://reactome.org/PathwayBrowser/#/R-HSA-2586552 | 11 | 2 | 0.101108689472188 | 19.7806935332708 | 0.0043573960882568 | 0.0395178740982864 | 2 | JAK2;LEPR |
| Signaling by NTRK3 (TRKC) | R-HSA-9034015 | http://reactome.org/PathwayBrowser/#/R-HSA-9034015 | 17 | 3 | 0.156258883729745 | 19.1989084293511 | 4.66234684805111E-4 | 0.0074993409206859 | 3 | BAX;PIK3R1;SRC |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | R-HSA-2173791 | http://reactome.org/PathwayBrowser/#/R-HSA-2173791 | 16 | 5 | 0.147067184686818 | 33.9980670103092 | 2.384322519422E-7 | 1.93584280743548E-5 | 5 | PRKCZ;RHOA;TGFB1;TGFBR1;UBC |
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| Note: Edges are drawn between pathways based on their common genes, and the edge width is based on the number of those genes. | |||||||||
