Selected Cell
Cell:
Value:
PathwayEnrichmentResults_Top30
PathwayNetwork_Top30
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| id | geneSet | link | size | overlap | expect | enrichmentRatio | pValue | FDR | gene_count | genes |
| AKT phosphorylates targets in the cytosol | R-HSA-198323 | http://reactome.org/PathwayBrowser/#/R-HSA-198323 | 14 | 3 | 0.131337060551501 | 22.8419913419913 | 2.70444727164642E-4 | 0.0055555212025989 | 3 | AKT1;CASP9;CDKN1A |
| AKT phosphorylates targets in the nucleus | R-HSA-198693 | http://reactome.org/PathwayBrowser/#/R-HSA-198693 | 9 | 2 | 0.0844309674973941 | 23.6879910213243 | 0.003004711501966 | 0.0303679190798684 | 2 | AKT1;FOXO1 |
| Activated NTRK3 signals through PI3K | R-HSA-9603381 | http://reactome.org/PathwayBrowser/#/R-HSA-9603381 | 6 | 2 | 0.0562873116649294 | 35.5319865319865 | 0.0012751850485552 | 0.0164711402105057 | 2 | PIK3CA;SRC |
| Activation of caspases through apoptosome-mediated cleavage | R-HSA-111459 | http://reactome.org/PathwayBrowser/#/R-HSA-111459 | 5 | 3 | 0.0469060930541078 | 63.9575757575757 | 7.9009928921625E-6 | 5.38847715245482E-4 | 3 | APAF1;CASP3;CASP9 |
| Activation of the AP-1 family of transcription factors | R-HSA-450341 | http://reactome.org/PathwayBrowser/#/R-HSA-450341 | 10 | 3 | 0.0938121861082156 | 31.9787878787878 | 9.16253201811434E-5 | 0.0027896637662294 | 3 | FOS;JUN;MAPK1 |
| Apoptotic cleavage of cell adhesion proteins | R-HSA-351906 | http://reactome.org/PathwayBrowser/#/R-HSA-351906 | 11 | 3 | 0.103193404719037 | 29.0716253443526 | 1.25127330950602E-4 | 0.0034974114634553 | 3 | CASP3;CDH1;CTNNB1 |
| Caspase-mediated cleavage of cytoskeletal proteins | R-HSA-264870 | http://reactome.org/PathwayBrowser/#/R-HSA-264870 | 12 | 3 | 0.112574623329858 | 26.6489898989899 | 1.65701352846658E-4 | 0.0040360115229079 | 3 | CASP3;GSN;VIM |
| Constitutive Signaling by EGFRvIII | R-HSA-5637810 | http://reactome.org/PathwayBrowser/#/R-HSA-5637810 | 15 | 3 | 0.140718279162323 | 21.3191919191919 | 3.35758612403092E-4 | 0.0063512165044631 | 3 | EGFR;HSP90AA1;PIK3CA |
| GAB1 signalosome | R-HSA-180292 | http://reactome.org/PathwayBrowser/#/R-HSA-180292 | 11 | 3 | 0.103193404719037 | 29.0716253443526 | 1.25127330950602E-4 | 0.0034974114634553 | 3 | EGFR;PIK3CA;SRC |
| InlA-mediated entry of Listeria monocytogenes into host cells | R-HSA-8876493 | http://reactome.org/PathwayBrowser/#/R-HSA-8876493 | 9 | 3 | 0.0844309674973941 | 35.5319865319865 | 6.45774251267772E-5 | 0.0022754975469103 | 3 | CDH1;CTNNB1;SRC |
| Interleukin-27 signaling | R-HSA-9020956 | http://reactome.org/PathwayBrowser/#/R-HSA-9020956 | 11 | 3 | 0.103193404719037 | 29.0716253443526 | 1.25127330950602E-4 | 0.0034974114634553 | 3 | JAK1;JAK2;STAT1 |
| Interleukin-9 signaling | R-HSA-8985947 | http://reactome.org/PathwayBrowser/#/R-HSA-8985947 | 9 | 2 | 0.0844309674973941 | 23.6879910213243 | 0.003004711501966 | 0.0303679190798684 | 2 | JAK1;STAT1 |
| Loss of Function of SMAD2/3 in Cancer | R-HSA-3304349 | http://reactome.org/PathwayBrowser/#/R-HSA-3304349 | 7 | 3 | 0.0656685302757509 | 45.6839826839826 | 2.72776718905909E-5 | 0.0013288123020987 | 3 | SMAD3;SMAD4;TGFB1 |
| MAPK1 (ERK2) activation | R-HSA-112411 | http://reactome.org/PathwayBrowser/#/R-HSA-112411 | 9 | 3 | 0.0844309674973941 | 35.5319865319865 | 6.45774251267772E-5 | 0.0022754975469103 | 3 | JAK1;JAK2;MAPK1 |
| MAPK3 (ERK1) activation | R-HSA-110056 | http://reactome.org/PathwayBrowser/#/R-HSA-110056 | 10 | 2 | 0.0938121861082156 | 21.3191919191919 | 0.0037329830474122 | 0.0357569443586394 | 2 | JAK1;JAK2 |
| PI3K/AKT activation | R-HSA-198203 | http://reactome.org/PathwayBrowser/#/R-HSA-198203 | 9 | 2 | 0.0844309674973941 | 23.6879910213243 | 0.003004711501966 | 0.0303679190798684 | 2 | PIK3CA;RHOA |
| PTK6 Expression | R-HSA-8849473 | http://reactome.org/PathwayBrowser/#/R-HSA-8849473 | 5 | 2 | 0.0469060930541078 | 42.6383838383838 | 8.55354774179417E-4 | 0.0122552931930748 | 2 | HIF1A;NR3C1 |
| PTK6 promotes HIF1A stabilization | R-HSA-8857538 | http://reactome.org/PathwayBrowser/#/R-HSA-8857538 | 6 | 2 | 0.0562873116649294 | 35.5319865319865 | 0.0012751850485552 | 0.0164711402105057 | 2 | EGFR;HIF1A |
| RSK activation | R-HSA-444257 | http://reactome.org/PathwayBrowser/#/R-HSA-444257 | 6 | 2 | 0.0562873116649294 | 35.5319865319865 | 0.0012751850485552 | 0.0164711402105057 | 2 | MAPK1;RPS6KA3 |
| RUNX2 regulates bone development | R-HSA-8941326 | http://reactome.org/PathwayBrowser/#/R-HSA-8941326 | 32 | 6 | 0.30019899554629 | 19.9867424242424 | 4.35266314990912E-7 | 4.94752711373003E-5 | 6 | MAPK1;RUNX2;SMAD1;SMAD4;SRC;YAP1 |
| RUNX2 regulates genes involved in cell migration | R-HSA-8941332 | http://reactome.org/PathwayBrowser/#/R-HSA-8941332 | 8 | 2 | 0.0750497488865725 | 26.6489898989899 | 0.0023513483737795 | 0.0258648321115755 | 2 | AKT1;RUNX2 |
| RUNX3 regulates BCL2L11 (BIM) transcription | R-HSA-8952158 | http://reactome.org/PathwayBrowser/#/R-HSA-8952158 | 5 | 2 | 0.0469060930541078 | 42.6383838383838 | 8.55354774179417E-4 | 0.0122552931930748 | 2 | SMAD3;SMAD4 |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | http://reactome.org/PathwayBrowser/#/R-HSA-8941855 | 7 | 5 | 0.0656685302757509 | 76.1399711399711 | 1.35801614398189E-9 | 3.85902920914856E-7 | 5 | CDKN1A;SMAD3;SMAD4;TGFB1;TP53 |
| Regulation of IFNG signaling | R-HSA-877312 | http://reactome.org/PathwayBrowser/#/R-HSA-877312 | 14 | 4 | 0.131337060551501 | 30.4559884559884 | 6.787526540597E-6 | 5.03162293552951E-4 | 4 | JAK1;JAK2;PTPN6;STAT1 |
| SMAC binds to IAPs | R-HSA-111463 | http://reactome.org/PathwayBrowser/#/R-HSA-111463 | 5 | 2 | 0.0469060930541078 | 42.6383838383838 | 8.55354774179417E-4 | 0.0122552931930748 | 2 | CASP3;CASP9 |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | http://reactome.org/PathwayBrowser/#/R-HSA-3304356 | 6 | 2 | 0.0562873116649294 | 35.5319865319865 | 0.0012751850485552 | 0.0164711402105057 | 2 | SMAD3;TGFB1 |
| Sema4D mediated inhibition of cell attachment and migration | R-HSA-416550 | http://reactome.org/PathwayBrowser/#/R-HSA-416550 | 8 | 2 | 0.0750497488865725 | 26.6489898989899 | 0.0023513483737795 | 0.0258648321115755 | 2 | RHOA;RRAS |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | R-HSA-2173791 | http://reactome.org/PathwayBrowser/#/R-HSA-2173791 | 16 | 3 | 0.150099497773145 | 19.9867424242424 | 4.10434246700397E-4 | 0.0075246278561739 | 3 | RHOA;SMURF1;TGFB1 |
| The NLRP3 inflammasome | R-HSA-844456 | http://reactome.org/PathwayBrowser/#/R-HSA-844456 | 15 | 4 | 0.140718279162323 | 28.4255892255892 | 9.18918621040099E-6 | 5.80280092175321E-4 | 4 | NFKB2;PYCARD;TXN;TXNIP |
| VLDLR internalisation and degradation | R-HSA-8866427 | http://reactome.org/PathwayBrowser/#/R-HSA-8866427 | 12 | 3 | 0.112574623329858 | 26.6489898989899 | 1.65701352846658E-4 | 0.0040360115229079 | 3 | CLTC;MYLIP;VLDLR |
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| Note: Edges are drawn between pathways based on their common genes, and the edge width is based on the number of those genes. | |||||||||
