Selected Cell
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stat_data__min_2_Peptides
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| Q00535 | Q00535 | CDK5_HUMAN | Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) | CDK5 | axon extension [GO:0048675]; axonogenesis [GO:0007409]; behavioral response to cocaine [GO:0048148]; calcium ion import [GO:0070509]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell-matrix adhesion [GO:0007160]; cellular response to amyloid-beta [GO:1904646]; central nervous system neuron development [GO:0021954]; cerebellar cortex formation [GO:0021697]; chemical synaptic transmission [GO:0007268]; corpus callosum development [GO:0022038]; dendrite morphogenesis [GO:0048813]; excitatory postsynaptic potential [GO:0060079]; hippocampus development [GO:0021766]; intracellular protein transport [GO:0006886]; layer formation in cerebral cortex [GO:0021819]; microtubule cytoskeleton organization [GO:0000226]; motor neuron axon guidance [GO:0008045]; negative regulation of axon extension [GO:0030517]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein export from nucleus [GO:0046826]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of proteolysis [GO:0045861]; negative regulation of synaptic plasticity [GO:0031914]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; oligodendrocyte differentiation [GO:0048709]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; phosphorylation [GO:0016310]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein targeting to membrane [GO:0090314]; protein localization to synapse [GO:0035418]; protein phosphorylation [GO:0006468]; receptor catabolic process [GO:0032801]; receptor clustering [GO:0043113]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell migration [GO:0030334]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of macroautophagy [GO:0016241]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of synaptic vesicle recycling [GO:1903421]; rhythmic process [GO:0048511]; Schwann cell development [GO:0014044]; sensory perception of pain [GO:0019233]; skeletal muscle tissue development [GO:0007519]; synapse assembly [GO:0007416]; synaptic transmission, dopaminergic [GO:0001963]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle exocytosis [GO:0016079]; synaptic vesicle transport [GO:0048489]; visual learning [GO:0008542] | axon [GO:0030424]; cell junction [GO:0030054]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; protein kinase 5 complex [GO:0016533] | acetylcholine receptor activator activity [GO:0030549]; ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; ErbB-2 class receptor binding [GO:0005176]; ErbB-3 class receptor binding [GO:0043125]; Hsp90 protein binding [GO:0051879]; kinase activity [GO:0016301]; p53 binding [GO:0002039]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321] | 18705.317956619598 | -0.208532841771363 | 0.0601025720648657 | 0.197186550850914 |
| O95749 | O95749 | GGPPS_HUMAN | Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10) | GGPS1 | farnesyl diphosphate biosynthetic process [GO:0045337]; geranyl diphosphate biosynthetic process [GO:0033384]; geranylgeranyl diphosphate biosynthetic process [GO:0033386]; isoprenoid biosynthetic process [GO:0008299]; isoprenoid metabolic process [GO:0006720]; plastoquinone biosynthetic process [GO:0010236]; ubiquinone biosynthetic process [GO:0006744] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; transferase complex [GO:1990234]; Z disc [GO:0030018] | dimethylallyltranstransferase activity [GO:0004161]; farnesyltranstransferase activity [GO:0004311]; geranyltranstransferase activity [GO:0004337]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; prenyltransferase activity [GO:0004659] | 12726.6394289183 | 0.246363931885229 | 0.0602230412564964 | 0.197467448934785 |
| Q13123 | Q13123 | RED_HUMAN | Protein Red (Cytokine IK) (IK factor) (Protein RER) | IK | mitotic cell cycle [GO:0000278]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mRNA splicing, via spliceosome [GO:0000398]; protein localization to kinetochore [GO:0034501] | chromosome [GO:0005694]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]; U2-type precatalytic spliceosome [GO:0071005] | identical protein binding [GO:0042802] | 13070.031070528301 | -0.16749179103484 | 0.0602807675541201 | 0.197542411198175 |
| P36915 | P36915 | GNL1_HUMAN | Guanine nucleotide-binding protein-like 1 (GTP-binding protein HSR1) | GNL1 | DNA damage response [GO:0006974]; signal transduction [GO:0007165]; T cell mediated immunity [GO:0002456] | extracellular space [GO:0005615]; nucleus [GO:0005634] | GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural molecule activity [GO:0005198] | 17326.1610243345 | 0.170988134391258 | 0.060623811892734 | 0.198255704022536 |
| O95470 | O95470 | SGPL1_HUMAN | Sphingosine-1-phosphate lyase 1 (S1PL) (SP-lyase 1) (SPL 1) (hSPL) (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase) | SGPL1 | androgen metabolic process [GO:0008209]; apoptotic signaling pathway [GO:0097190]; ceramide metabolic process [GO:0006672]; coenzyme A biosynthetic process [GO:0015937]; estrogen metabolic process [GO:0008210]; face morphogenesis [GO:0060325]; fatty acid metabolic process [GO:0006631]; fibroblast migration [GO:0010761]; hemopoiesis [GO:0030097]; kidney development [GO:0001822]; Leydig cell differentiation [GO:0033327]; luteinization [GO:0001553]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; post-embryonic development [GO:0009791]; regulation of multicellular organism growth [GO:0040014]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705]; spermatogenesis [GO:0007283]; sphingolipid catabolic process [GO:0030149]; vasculogenesis [GO:0001570] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] | aspartate 1-decarboxylase activity [GO:0004068]; pyridoxal phosphate binding [GO:0030170]; sphinganine-1-phosphate aldolase activity [GO:0008117] | 11834.45049963105 | -0.272031998365763 | 0.0606383930587813 | 0.198255704022536 |
| P49459 | P49459 | UBE2A_HUMAN | Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A) | UBE2A | chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]; G2/M transition of mitotic cell cycle [GO:0000086]; postreplication repair [GO:0006301]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; response to UV [GO:0009411]; ubiquitin-dependent protein catabolic process [GO:0006511] | chromatin [GO:0000785]; cytosol [GO:0005829]; HULC complex [GO:0033503]; nucleoplasm [GO:0005654] | ATP binding [GO:0005524]; histone ubiquitin ligase activity [GO:0140852]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842] | 16591.30085620615 | 0.353853902255177 | 0.0605750719249643 | 0.198255704022536 |
| O43776 | O43776 | SYNC_HUMAN | Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS) (Asparaginyl-tRNA synthetase 1) | NARS1 | asparaginyl-tRNA aminoacylation [GO:0006421]; cell migration [GO:0016477]; cerebral cortex development [GO:0021987]; tRNA aminoacylation for protein translation [GO:0006418] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] | asparagine-tRNA ligase activity [GO:0004816]; ATP binding [GO:0005524]; CCR3 chemokine receptor binding [GO:0031728]; nucleic acid binding [GO:0003676]; protein dimerization activity [GO:0046983] | 129315.7299265115 | -0.212140558568085 | 0.0608716789179326 | 0.198789010229975 |
| Q96PE2 | Q96PE2 | ARHGH_HUMAN | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | ARHGEF17 | actin cytoskeleton organization [GO:0030036]; regulation of small GTPase mediated signal transduction [GO:0051056] | cytosol [GO:0005829] | guanyl-nucleotide exchange factor activity [GO:0005085] | 5791.993362883664 | -0.454630130401253 | 0.0610877357401698 | 0.199379672064402 |
| O14966 | O14966 | RAB7L_HUMAN | Ras-related protein Rab-7L1 (Rab-7-like protein 1) (Ras-related protein Rab-29) | RAB29 | cell differentiation [GO:0030154]; cellular detoxification [GO:1990748]; endosome to lysosome transport [GO:0008333]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; melanosome organization [GO:0032438]; mitochondrion organization [GO:0007005]; modulation by host of viral process [GO:0044788]; negative regulation of neuron projection development [GO:0010977]; phagosome-lysosome fusion [GO:0090385]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of receptor recycling [GO:0001921]; positive regulation of T cell receptor signaling pathway [GO:0050862]; protein localization to ciliary membrane [GO:1903441]; protein localization to membrane [GO:0072657]; regulation of retrograde transport, endosome to Golgi [GO:1905279]; response to bacterium [GO:0009617]; retrograde transport, endosome to Golgi [GO:0042147]; synapse assembly [GO:0007416]; T cell activation [GO:0042110] | cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; intracellular vesicle [GO:0097708]; late endosome [GO:0005770]; lysosome [GO:0005764]; melanosome [GO:0042470]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802]; vacuole [GO:0005773] | dynein complex binding [GO:0070840]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; kinesin binding [GO:0019894]; small GTPase binding [GO:0031267] | 63916.844545793 | -1.04188706032494 | 0.0615196780502653 | 0.200673860583076 |
| Q9H6S1 | Q9H6S1 | AZI2_HUMAN | 5-azacytidine-induced protein 2 (NF-kappa-B-activating kinase-associated protein 1) (Nak-associated protein 1) (Nap1) (TILP) | AZI2 | canonical NF-kappaB signal transduction [GO:0007249]; defense response to virus [GO:0051607]; dendritic cell differentiation [GO:0097028]; dendritic cell proliferation [GO:0044565]; mitotic cell cycle [GO:0000278]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; T cell activation [GO:0042110]; type I interferon-mediated signaling pathway [GO:0060337] | cytoplasm [GO:0005737]; serine/threonine protein kinase complex [GO:1902554] | 7224.08391838389 | -1.51178074964229 | 0.0615750474222115 | 0.200738906038119 | |
| Q5M775 | Q5M775 | CYTSB_HUMAN | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | SPECC1 | actin cytoskeleton organization [GO:0030036]; associative learning [GO:0008306]; blastocyst development [GO:0001824] | apical part of cell [GO:0045177]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; filamentous actin [GO:0031941]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654] | 3823.065641400045 | -0.934833086280743 | 0.0623528289377359 | 0.203157635860386 | |
| P54687 | P54687 | BCAT1_HUMAN | Branched-chain-amino-acid aminotransferase, cytosolic (BCAT(c)) (EC 2.6.1.42) (Protein ECA39) | BCAT1 | amino acid biosynthetic process [GO:0008652]; branched-chain amino acid biosynthetic process [GO:0009082]; G1/S transition of mitotic cell cycle [GO:0000082]; leucine biosynthetic process [GO:0009098]; lipid metabolic process [GO:0006629]; valine biosynthetic process [GO:0009099] | cytosol [GO:0005829]; mitochondrion [GO:0005739] | branched-chain-amino-acid transaminase activity [GO:0004084]; L-isoleucine transaminase activity [GO:0052656]; L-leucine transaminase activity [GO:0052654]; L-leucine:2-oxoglutarate aminotransferase activity [GO:0050048]; L-valine transaminase activity [GO:0052655] | 144058.6855200885 | -0.114703880874614 | 0.0624859759749795 | 0.203474448203582 |
| O60547 | O60547 | GMDS_HUMAN | GDP-mannose 4,6 dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD) | GMDS | 'de novo' GDP-L-fucose biosynthetic process [GO:0042351]; GDP-mannose metabolic process [GO:0019673]; Notch signaling pathway [GO:0007219] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] | GDP-mannose 4,6-dehydratase activity [GO:0008446]; identical protein binding [GO:0042802]; NADP+ binding [GO:0070401] | 6666.58503053924 | 0.13290210938085 | 0.0626135352304793 | 0.203521746005368 |
| Q9HCN4 | Q9HCN4 | GPN1_HUMAN | GPN-loop GTPase 1 (EC 3.6.5.-) (MBD2-interacting protein) (MBDin) (RNAPII-associated protein 4) (XPA-binding protein 1) | GPN1 | cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] | ATP hydrolysis activity [GO:0016887]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] | 11169.5799748122 | 0.588416536892895 | 0.0625758398221829 | 0.203521746005368 | |
| P46776 | P46776 | RL27A_HUMAN | Large ribosomal subunit protein uL15 (60S ribosomal protein L27a) | RPL27A | cytoplasmic translation [GO:0002181]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleoplasm [GO:0005654] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 1173902.55884687 | 0.367033353183396 | 0.0626441802035585 | 0.203521746005368 |
| P63000 | P63000 | RAC1_HUMAN | Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1) | RAC1 | actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; actin filament polymerization [GO:0030041]; anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; cell motility [GO:0048870]; cell projection assembly [GO:0030031]; cell-matrix adhesion [GO:0007160]; cortical cytoskeleton organization [GO:0030865]; engulfment of apoptotic cell [GO:0043652]; establishment or maintenance of cell polarity [GO:0007163]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; lamellipodium assembly [GO:0030032]; localization [GO:0051179]; localization within membrane [GO:0051668]; motor neuron axon guidance [GO:0008045]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of interleukin-23 production [GO:0032707]; negative regulation of receptor-mediated endocytosis [GO:0048261]; neuron migration [GO:0001764]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; Rac protein signal transduction [GO:0016601]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of lamellipodium assembly [GO:0010591]; regulation of neutrophil migration [GO:1902622]; regulation of nitric oxide biosynthetic process [GO:0045428]; regulation of respiratory burst [GO:0060263]; regulation of stress fiber assembly [GO:0051492]; respiratory burst [GO:0045730]; response to wounding [GO:0009611]; ruffle assembly [GO:0097178]; ruffle organization [GO:0031529]; semaphorin-plexin signaling pathway [GO:0071526]; small GTPase-mediated signal transduction [GO:0007264]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; substrate adhesion-dependent cell spreading [GO:0034446]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071] | cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; melanosome [GO:0042470]; membrane [GO:0016020]; NADPH oxidase complex [GO:0043020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; recycling endosome membrane [GO:0055038]; ruffle membrane [GO:0032587]; secretory granule membrane [GO:0030667]; trans-Golgi network [GO:0005802] | enzyme binding [GO:0019899]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; Rho GDP-dissociation inhibitor binding [GO:0051022]; thioesterase binding [GO:0031996] | 487898.87705872 | -0.403218365371304 | 0.0627415910804735 | 0.203721406912299 |
| Q15631 | Q15631 | TSN_HUMAN | Translin (EC 3.1.-.-) (Component 3 of promoter of RISC) (C3PO) | TSN | DNA recombination [GO:0006310]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; siRNA processing [GO:0030422] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoribonuclease complex [GO:1902555]; male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; single-stranded DNA binding [GO:0003697] | 99314.35803176386 | -0.20024566012679 | 0.0629731999515262 | 0.204356329281413 |
| P51398 | P51398 | RT29_HUMAN | Small ribosomal subunit protein mS29 (28S ribosomal protein S29, mitochondrial) (MRP-S29) (S29mt) (Death-associated protein 3) (DAP-3) (Ionizing radiation resistance conferring protein) | DAP3 | apoptotic signaling pathway [GO:0097190]; mitochondrial translation [GO:0032543] | mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] | GTP binding [GO:0005525]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 6990.157085104325 | 0.115868741926043 | 0.063018891264351 | 0.204387543161885 |
| Q9BUR5 | Q9BUR5 | MIC26_HUMAN | MICOS complex subunit MIC26 (Apolipoprotein O) (MICOS complex subunit MIC23) (Protein FAM121B) | APOO | cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]; lipid transport [GO:0006869] | cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; high-density lipoprotein particle [GO:0034364]; low-density lipoprotein particle [GO:0034362]; MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; SAM complex [GO:0001401]; very-low-density lipoprotein particle [GO:0034361] | 20189.3655332933 | 0.353395147415088 | 0.0630966854728156 | 0.20452278025685 | |
| Q9BYD6 | Q9BYD6 | RM01_HUMAN | Large ribosomal subunit protein uL1m (39S ribosomal protein L1, mitochondrial) (L1mt) (MRP-L1) | MRPL1 | mitochondrial translation [GO:0032543] | cytosolic large ribosomal subunit [GO:0022625]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 9321.218814652711 | 0.311463171159651 | 0.0631468110962674 | 0.204568228514266 |
| O43633 | O43633 | CHM2A_HUMAN | Charged multivesicular body protein 2a (Chromatin-modifying protein 2a) (CHMP2a) (Putative breast adenocarcinoma marker BC-2) (Vacuolar protein sorting-associated protein 2-1) (Vps2-1) (hVps2-1) | CHMP2A | autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; endosome transport via multivesicular body sorting pathway [GO:0032509]; ESCRT III complex disassembly [GO:1904903]; establishment of protein localization [GO:0045184]; exit from mitosis [GO:0010458]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; membrane invagination [GO:0010324]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; negative regulation of centriole elongation [GO:1903723]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; positive regulation of exosomal secretion [GO:1903543]; protein homooligomerization [GO:0051260]; protein polymerization [GO:0051258]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076] | amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; chromatin [GO:0000785]; cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; membrane coat [GO:0030117]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886] | phosphatidylcholine binding [GO:0031210]; protein domain specific binding [GO:0019904] | 35684.57822618825 | 0.343977547779104 | 0.0635165808458195 | 0.205548787873311 |
| Q9NR50 | Q9NR50 | EI2BG_HUMAN | Translation initiation factor eIF2B subunit gamma (eIF2B GDP-GTP exchange factor subunit gamma) | EIF2B3 | cytoplasmic translational initiation [GO:0002183]; oligodendrocyte development [GO:0014003]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; T cell receptor signaling pathway [GO:0050852]; translational initiation [GO:0006413] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]; guanyl-nucleotide exchange factor complex [GO:0032045] | guanyl-nucleotide exchange factor activity [GO:0005085]; translation initiation factor activity [GO:0003743] | 8700.173444920005 | -0.169871679723985 | 0.0635220486350456 | 0.205548787873311 |
| Q9BVM2 | Q9BVM2 | DPCD_HUMAN | Protein DPCD | DPCD | determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; lateral ventricle development [GO:0021670]; spermatogenesis [GO:0007283]; third ventricle development [GO:0021678] | extracellular region [GO:0005576]; nucleus [GO:0005634] | 21765.67011311785 | 0.198013035345559 | 0.06361663478199 | 0.205737358832623 | |
| Q2TAA2 | Q2TAA2 | IAH1_HUMAN | Isoamyl acetate-hydrolyzing esterase 1 homolog (EC 3.1.-.-) | IAH1 | lipid catabolic process [GO:0016042] | hydrolase activity, acting on ester bonds [GO:0016788]; identical protein binding [GO:0042802] | 11380.853884741751 | -0.624561145687996 | 0.0640098478923351 | 0.206772975004544 | |
| P01116 | P01116 | RASK_HUMAN | GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed] | KRAS | actin cytoskeleton organization [GO:0030036]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; forebrain astrocyte development [GO:0021897]; gene expression [GO:0010467]; glial cell proliferation [GO:0014009]; homeostasis of number of cells within a tissue [GO:0048873]; MAPK cascade [GO:0000165]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of neuron apoptotic process [GO:0043524]; neuron apoptotic process [GO:0051402]; positive regulation of gene expression [GO:0010628]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Rac protein signal transduction [GO:0035022]; Rac protein signal transduction [GO:0016601]; Ras protein signal transduction [GO:0007265]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of synaptic transmission, GABAergic [GO:0032228]; skeletal muscle cell differentiation [GO:0035914]; striated muscle cell differentiation [GO:0051146]; type I pneumocyte differentiation [GO:0060509]; visual learning [GO:0008542] | cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886] | G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; protein-membrane adaptor activity [GO:0043495] | 44556.7690845973 | 0.294119261094295 | 0.0640042610664281 | 0.206772975004544 |
| Q13619 | Q13619 | CUL4A_HUMAN | Cullin-4A (CUL-4A) | CUL4A | cell population proliferation [GO:0008283]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; G1/S transition of mitotic cell cycle [GO:0000082]; hemopoiesis [GO:0030097]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of granulocyte differentiation [GO:0030853]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of protein catabolic process [GO:0045732]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of DNA damage checkpoint [GO:2000001]; regulation of nucleotide-excision repair [GO:2000819]; rhythmic process [GO:0048511]; ribosome biogenesis [GO:0042254]; somatic stem cell population maintenance [GO:0035019]; spermatogenesis [GO:0007283]; T cell activation [GO:0042110]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627] | Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | ubiquitin ligase complex scaffold activity [GO:0160072]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625] | 8282.21831862592 | -0.233197094870728 | 0.0640671373578651 | 0.206840114113768 |
| P35914 | P35914 | HMGCL_HUMAN | Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase) | HMGCL | ketone body biosynthetic process [GO:0046951]; leucine catabolic process [GO:0006552]; lipid metabolic process [GO:0006629]; mitochondrion organization [GO:0007005] | cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991] | hydroxymethylglutaryl-CoA lyase activity [GO:0004419]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; metal ion binding [GO:0046872]; structural molecule activity [GO:0005198] | 12451.8137055443 | -0.487614574432885 | 0.0641245749300483 | 0.206907654643311 |
| P46063 | P46063 | RECQ1_HUMAN | ATP-dependent DNA helicase Q1 (EC 5.6.2.4) (DNA 3'-5' helicase Q1) (DNA helicase, RecQ-like type 1) (RecQ1) (DNA-dependent ATPase Q1) (RecQ protein-like 1) | RECQL | DNA repair [GO:0006281]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via homologous recombination [GO:0000724]; replication fork processing [GO:0031297] | chromosome [GO:0005694]; cytoplasm [GO:0005737]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; DNA/DNA annealing activity [GO:1990814]; double-stranded DNA helicase activity [GO:0036121]; four-way junction helicase activity [GO:0009378]; isomerase activity [GO:0016853]; metal ion binding [GO:0046872] | 25789.54455731005 | 0.120157256294073 | 0.064287606403373 | 0.207315639090217 |
| Q9UMX5 | Q9UMX5 | NENF_HUMAN | Neudesin (Cell immortalization-related protein 2) (Neuron-derived neurotrophic factor) (Protein GIG47) (Secreted protein of unknown function) (SPUF protein) | NENF | MAPK cascade [GO:0000165]; negative regulation of appetite [GO:0032099]; positive regulation of MAPK cascade [GO:0043410] | endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrion [GO:0005739] | growth factor activity [GO:0008083]; metal ion binding [GO:0046872] | 40907.0826820316 | 0.328979147846464 | 0.0646092859586756 | 0.208234479090931 |
| Q13488 | Q13488 | VPP3_HUMAN | V-type proton ATPase 116 kDa subunit a 3 (V-ATPase 116 kDa subunit a 3) (Osteoclastic proton pump 116 kDa subunit) (OC-116 kDa) (OC116) (T-cell immune regulator 1) (T-cell immune response cDNA7 protein) (TIRC7) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3) | TCIRG1 | apoptotic process [GO:0006915]; autophagosome assembly [GO:0000045]; B cell differentiation [GO:0030183]; bone resorption [GO:0045453]; cellular defense response [GO:0006968]; cellular response to cytokine stimulus [GO:0071345]; dentin mineralization [GO:0097188]; enamel mineralization [GO:0070166]; establishment of cell polarity [GO:0030010]; establishment of vesicle localization [GO:0051650]; gene expression [GO:0010467]; hematopoietic stem cell homeostasis [GO:0061484]; immunoglobulin mediated immune response [GO:0016064]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; lysosomal lumen acidification [GO:0007042]; macroautophagy [GO:0016236]; memory T cell activation [GO:0035709]; optic nerve development [GO:0021554]; ossification [GO:0001503]; osteoclast differentiation [GO:0030316]; osteoclast proliferation [GO:0002158]; pH reduction [GO:0045851]; phagosome acidification [GO:0090383]; positive regulation of cell population proliferation [GO:0008284]; protein catabolic process in the vacuole [GO:0007039]; protein localization to organelle [GO:0033365]; proton transmembrane transport [GO:1902600]; regulation of gene expression [GO:0010468]; regulation of insulin secretion [GO:0050796]; regulation of osteoblast differentiation [GO:0045667]; regulation of proton transport [GO:0010155]; response to silver ion [GO:0010272]; retina development in camera-type eye [GO:0060041]; ruffle organization [GO:0031529]; T cell differentiation [GO:0030217]; T cell homeostasis [GO:0043029]; T-helper 1 cell activation [GO:0035711]; tooth eruption [GO:0044691]; vacuolar acidification [GO:0007035] | apical plasma membrane [GO:0016324]; endosome membrane [GO:0010008]; ficolin-1-rich granule membrane [GO:0101003]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; nucleus [GO:0005634]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220] | ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961] | 21616.996362197548 | -0.139422081685762 | 0.0647346349682367 | 0.20851986454237 |
| P30086 | P30086 | PEBP1_HUMAN | Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)] | PEBP1 | negative regulation of MAPK cascade [GO:0043409] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] | ATP binding [GO:0005524]; enzyme binding [GO:0019899]; phosphatidylethanolamine binding [GO:0008429]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; serine-type endopeptidase inhibitor activity [GO:0004867] | 357602.139344516 | 0.260798136421815 | 0.0649498909844144 | 0.209094364953234 |
| Q01650 | Q01650 | LAT1_HUMAN | Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic amino acid transporter) | SLC7A5 | alanine transport [GO:0032328]; amino acid import across plasma membrane [GO:0089718]; amino acid transmembrane transport [GO:0003333]; cellular response to glucose starvation [GO:0042149]; cellular response to L-arginine [GO:1903577]; cellular response to lipopolysaccharide [GO:0071222]; isoleucine transport [GO:0015818]; L-histidine transport [GO:1902024]; L-leucine import across plasma membrane [GO:1903801]; L-tryptophan transmembrane transport [GO:1904556]; leucine import across plasma membrane [GO:0098713]; leucine transport [GO:0015820]; liver regeneration [GO:0097421]; methionine transport [GO:0015821]; negative regulation of autophagy [GO:0010507]; negative regulation of gene expression [GO:0010629]; negative regulation of vascular associated smooth muscle cell apoptotic process [GO:1905460]; neutral amino acid transport [GO:0015804]; phenylalanine transport [GO:0015823]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of leucine import across plasma membrane [GO:1905534]; positive regulation of type II interferon production [GO:0032729]; proline transport [GO:0015824]; response to hyperoxia [GO:0055093]; response to muscle activity [GO:0014850]; thyroid hormone transport [GO:0070327]; transport across blood-brain barrier [GO:0150104]; tryptophan transport [GO:0015827]; tyrosine transport [GO:0015828]; valine transport [GO:0015829]; xenobiotic transport [GO:0042908] | amino acid transport complex [GO:1990184]; apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; external side of apical plasma membrane [GO:0098591]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886] | amino acid transmembrane transporter activity [GO:0015171]; antiporter activity [GO:0015297]; aromatic amino acid transmembrane transporter activity [GO:0015173]; L-amino acid transmembrane transporter activity [GO:0015179]; L-leucine transmembrane transporter activity [GO:0015190]; L-tryptophan transmembrane transporter activity [GO:0015196]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; peptide antigen binding [GO:0042605]; thyroid hormone transmembrane transporter activity [GO:0015349] | 27595.0004621678 | -0.227585414964167 | 0.0650134510175416 | 0.209180132575463 |
| Q6ZRP7 | Q6ZRP7 | QSOX2_HUMAN | Sulfhydryl oxidase 2 (EC 1.8.3.2) (Neuroblastoma-derived sulfhydryl oxidase) (Quiescin Q6-like protein 1) | QSOX2 | protein folding [GO:0006457] | extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] | flavin-dependent sulfhydryl oxidase activity [GO:0016971]; protein disulfide isomerase activity [GO:0003756] | 6759.36978631329 | 0.181562499076586 | 0.0651780792000548 | 0.209590804056476 |
| P41236 | P41236 | IPP2_HUMAN | Protein phosphatase inhibitor 2 (IPP-2) | PPP1R2 | generation of precursor metabolites and energy [GO:0006091]; glycogen metabolic process [GO:0005977]; regulation of signal transduction [GO:0009966] | molecular function inhibitor activity [GO:0140678]; protein phosphatase inhibitor activity [GO:0004864]; protein serine/threonine phosphatase inhibitor activity [GO:0004865] | 24494.978534551097 | 0.380927381066992 | 0.0653450361166312 | 0.210008493838249 | |
| Q9UHY8 | Q9UHY8 | FEZ2_HUMAN | Fasciculation and elongation protein zeta-2 (Zygin II) (Zygin-2) | FEZ2 | axon guidance [GO:0007411]; negative regulation of autophagosome assembly [GO:1902902]; nervous system development [GO:0007399]; signal transduction [GO:0007165] | axon [GO:0030424]; cytoplasm [GO:0005737] | 7688.290219949649 | 0.218913054943152 | 0.0660785468409547 | 0.212005122537287 | |
| Q15036 | Q15036 | SNX17_HUMAN | Sorting nexin-17 | SNX17 | aorta development [GO:0035904]; cardiac septum development [GO:0003279]; cholesterol catabolic process [GO:0006707]; coronary vasculature development [GO:0060976]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; intracellular protein transport [GO:0006886]; kidney development [GO:0001822]; receptor-mediated endocytosis [GO:0006898]; regulation of endocytosis [GO:0030100]; signal transduction [GO:0007165] | cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; protein-containing complex [GO:0032991] | low-density lipoprotein particle receptor binding [GO:0050750]; phosphatidylinositol binding [GO:0035091]; signaling receptor binding [GO:0005102] | 19207.55726125245 | -0.100327228071659 | 0.0660649790820449 | 0.212005122537287 |
| P16930 | P16930 | FAAA_HUMAN | Fumarylacetoacetase (FAA) (EC 3.7.1.2) (Beta-diketonase) (Fumarylacetoacetate hydrolase) | FAH | arginine catabolic process [GO:0006527]; homogentisate catabolic process [GO:1902000]; L-phenylalanine catabolic process [GO:0006559]; lipid metabolic process [GO:0006629]; tyrosine catabolic process [GO:0006572] | cytosol [GO:0005829]; extracellular exosome [GO:0070062] | fumarylacetoacetase activity [GO:0004334]; metal ion binding [GO:0046872] | 11782.332254177949 | 0.154354500664539 | 0.0663626257460929 | 0.212796059692905 |
| Q14320 | Q14320 | FA50A_HUMAN | Protein FAM50A (Protein HXC-26) (Protein XAP-5) | FAM50A | chromatin organization [GO:0006325]; mRNA processing [GO:0006397]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; spermatogenesis [GO:0007283] | nucleoplasm [GO:0005654]; nucleus [GO:0005634] | RNA binding [GO:0003723] | 21251.0119829254 | 0.255063320311572 | 0.0665002965222651 | 0.213116900506309 |
| Q9UL45 | Q9UL45 | BL1S6_HUMAN | Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC-1 subunit 6) (Pallid protein homolog) (Pallidin) (Syntaxin 13-interacting protein) | BLOC1S6 | actin filament bundle assembly [GO:0051017]; adenosine metabolic process [GO:0046085]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; ATP metabolic process [GO:0046034]; blood coagulation [GO:0007596]; bradykinin biosynthetic process [GO:0002936]; cellular response to epidermal growth factor stimulus [GO:0071364]; cilium assembly [GO:0060271]; circadian sleep/wake cycle [GO:0042745]; dentate gyrus development [GO:0021542]; endosome to melanosome transport [GO:0035646]; endothelium development [GO:0003158]; gene expression [GO:0010467]; glutamate metabolic process [GO:0006536]; glutamine metabolic process [GO:0006541]; homeostasis of number of cells [GO:0048872]; hypothalamus development [GO:0021854]; intracellular nitric oxide homeostasis [GO:0033484]; intracellular transport [GO:0046907]; kidney development [GO:0001822]; lipid homeostasis [GO:0055088]; lung alveolus development [GO:0048286]; melanocyte differentiation [GO:0030318]; melanosome organization [GO:0032438]; melanosome transport [GO:0032402]; membrane fusion [GO:0061025]; memory [GO:0007613]; multicellular organism growth [GO:0035264]; neuron projection development [GO:0031175]; phospholipid metabolic process [GO:0006644]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of pigment cell differentiation [GO:0050942]; protein targeting [GO:0006605]; protein transmembrane transport [GO:0071806]; respiratory system process [GO:0003016]; response to acetylcholine [GO:1905144]; response to activity [GO:0014823]; response to xenobiotic stimulus [GO:0009410]; secretion of lysosomal enzymes [GO:0033299]; synaptic vesicle docking [GO:0016081]; vasodilation [GO:0042311] | axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; cell-cell contact zone [GO:0044291]; contractile ring [GO:0070938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; filamentous actin [GO:0031941]; focal adhesion [GO:0005925]; membrane [GO:0016020]; membrane-bounded organelle [GO:0043227]; microvesicle [GO:1990742]; presynapse [GO:0098793]; ruffle [GO:0001726]; stress fiber [GO:0001725]; transport vesicle [GO:0030133] | actin filament binding [GO:0051015]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; syntaxin binding [GO:0019905] | 3210.7052717104098 | 1.88727842517788 | 0.0665516137961222 | 0.21316079353806 |
| Q5XKK7 | Q5XKK7 | F219B_HUMAN | Protein FAM219B | FAM219B | 3580.0210974738548 | 0.475500493823916 | 0.0667232708865808 | 0.213589860363484 | |||
| Q9UHN6 | Q9UHN6 | CEIP2_HUMAN | Inactive cell surface hyaluronidase CEMIP2 (Cell migration-inducing hyaluronidase 2) (Transmembrane protein 2) | CEMIP2 | angiogenesis [GO:0001525]; hyaluronan catabolic process [GO:0030214]; regulation of sprouting angiogenesis [GO:1903670] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] | cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246] | 11045.29169382005 | -0.187844957923884 | 0.066874294868599 | 0.21395064815314 |
| O43143 | O43143 | DHX15_HUMAN | ATP-dependent RNA helicase DHX15 (EC 3.6.4.13) (ATP-dependent RNA helicase #46) (DEAH box protein 15) (Splicing factor Prp43) (hPrp43) | DHX15 | antiviral innate immune response [GO:0140374]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; response to alkaloid [GO:0043279]; response to toxic substance [GO:0009636]; RNA splicing [GO:0008380] | nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on RNA [GO:0008186]; double-stranded RNA binding [GO:0003725]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] | 24994.1363568168 | -0.192111045806896 | 0.0669114981516704 | 0.21395064815314 |
| Q27J81 | Q27J81 | INF2_HUMAN | Inverted formin-2 (HBEBP2-binding protein C) | INF2 | actin filament polymerization [GO:0030041]; regulation of mitochondrial fission [GO:0090140] | actin filament [GO:0005884]; perinuclear region of cytoplasm [GO:0048471] | actin binding [GO:0003779]; small GTPase binding [GO:0031267] | 18675.5523176405 | -0.229388530370152 | 0.067204324199083 | 0.21464470175423 |
| O95169 | O95169 | NDUB8_HUMAN | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (Complex I-ASHI) (CI-ASHI) (NADH-ubiquinone oxidoreductase ASHI subunit) | NDUFB8 | aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776] | endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739] | NADH dehydrogenase (ubiquinone) activity [GO:0008137] | 32745.3316408165 | 0.206591069935567 | 0.0672804319885934 | 0.214766719801335 |
| Q8NEZ2 | Q8NEZ2 | VP37A_HUMAN | Vacuolar protein sorting-associated protein 37A (hVps37A) (ESCRT-I complex subunit VPS37A) (Hepatocellular carcinoma-related protein 1) | VPS37A | macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein targeting to membrane [GO:0006612]; protein targeting to vacuole [GO:0006623]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding via host ESCRT complex [GO:0039702] | centrosome [GO:0005813]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; nucleoplasm [GO:0005654] | 14340.6635403895 | 0.348655360884675 | 0.0673262778506768 | 0.214792055350188 | |
| P53999 | P53999 | TCP4_HUMAN | Activated RNA polymerase II transcriptional coactivator p15 (Positive cofactor 4) (PC4) (SUB1 homolog) (p14) | SUB1 | negative regulation of DNA duplex unwinding [GO:1905463]; negative regulation of DNA metabolic process [GO:0051053]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II promoter clearance [GO:0001111] | extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] | identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; single-stranded DNA binding [GO:0003697]; transcription coactivator activity [GO:0003713] | 163732.5682760795 | 0.351315911010217 | 0.0682277464954111 | 0.217545532719752 |
| Q7L5D6 | Q7L5D6 | GET4_HUMAN | Golgi to ER traffic protein 4 homolog (Conserved edge-expressed protein) (Transmembrane domain recognition complex 35 kDa subunit) (TRC35) | GET4 | cytoplasmic sequestering of protein [GO:0051220]; ERAD pathway [GO:0036503]; maintenance of unfolded protein [GO:0036506]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; protein insertion into ER membrane [GO:0045048]; regulation of protein stability [GO:0031647]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]; ubiquitin-dependent protein catabolic process [GO:0006511] | BAT3 complex [GO:0071818]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; TRC complex [GO:0072380] | protein-folding chaperone binding [GO:0051087] | 23184.2053144386 | 0.214914708421744 | 0.0683175787566918 | 0.217709449513732 |
| Q7L2E3 | Q7L2E3 | DHX30_HUMAN | ATP-dependent RNA helicase DHX30 (EC 3.6.4.13) (DEAH box protein 30) | DHX30 | central nervous system development [GO:0007417]; mitochondrial large ribosomal subunit assembly [GO:1902775] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; ribonucleoprotein granule [GO:0035770] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; DNA helicase activity [GO:0003678]; double-stranded RNA binding [GO:0003725]; G-quadruplex RNA binding [GO:0002151]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] | 6524.417714496535 | -0.284957908979919 | 0.0684098037344416 | 0.217868190528689 |
| Q9Y3E5 | Q9Y3E5 | PTH2_HUMAN | Peptidyl-tRNA hydrolase 2, mitochondrial (PTH 2) (EC 3.1.1.29) (Bcl-2 inhibitor of transcription 1) | PTRH2 | apoptotic process [GO:0006915]; negative regulation of anoikis [GO:2000811]; negative regulation of gene expression [GO:0010629]; positive regulation of anoikis [GO:2000210] | cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] | aminoacyl-tRNA hydrolase activity [GO:0004045] | 25105.0494429132 | -0.368564052400295 | 0.0684442956479115 | 0.217868190528689 |
| O94885 | O94885 | SASH1_HUMAN | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | SASH1 | positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of p38MAPK cascade [GO:1900745]; protein polyubiquitination [GO:0000209]; regulation of epithelial cell migration [GO:0010632]; regulation of protein autoubiquitination [GO:1902498]; regulation of protein K63-linked ubiquitination [GO:1900044] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991] | G-protein alpha-subunit binding [GO:0001965]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901] | 5849.716092722965 | -0.425839240893619 | 0.0690101338125413 | 0.219422793592513 |
| Q9BWQ6 | Q9BWQ6 | YIPF2_HUMAN | Protein YIPF2 (YIP1 family member 2) | YIPF2 | vesicle-mediated transport [GO:0016192] | Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi trans cisterna [GO:0000138]; late endosome membrane [GO:0031902]; trans-Golgi network [GO:0005802]; transport vesicle [GO:0030133] | small GTPase binding [GO:0031267] | 11157.56348007985 | 1.08882018675142 | 0.0691897547632025 | 0.219747281663848 |
| P51668;Q9Y2X8 | P51668 | UB2D1_HUMAN | Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1) | UBE2D1 | negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein polyubiquitination [GO:1902916]; positive regulation of protein ubiquitination [GO:0031398]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ubiquitin ligase complex [GO:0000151] | ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842] | 109907.0042217125 | 0.31328254472139 | 0.069253746728505 | 0.219827299139333 |
| Q13217 | Q13217 | DNJC3_HUMAN | DnaJ homolog subfamily C member 3 (Endoplasmic reticulum DNA J domain-containing protein 6) (ER-resident protein ERdj6) (ERdj6) (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor of 58 kDa) (Protein kinase inhibitor p58) | DNAJC3 | cellular response to cold [GO:0070417]; defense response to virus [GO:0051607]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:1903912]; positive regulation of translation initiation in response to endoplasmic reticulum stress [GO:0036494]; protein folding in endoplasmic reticulum [GO:0034975]; proteolysis involved in protein catabolic process [GO:0051603]; response to unfolded protein [GO:0006986] | azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; membrane [GO:0016020]; smooth endoplasmic reticulum [GO:0005790] | misfolded protein binding [GO:0051787]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; protein-folding chaperone binding [GO:0051087] | 23164.4159699208 | 0.197099665844437 | 0.0693251238195889 | 0.219930655969648 |
| Q16270 | Q16270 | IBP7_HUMAN | Insulin-like growth factor-binding protein 7 (IBP-7) (IGF-binding protein 7) (IGFBP-7) (IGFBP-rP1) (MAC25 protein) (PGI2-stimulating factor) (Prostacyclin-stimulating factor) (Tumor-derived adhesion factor) (TAF) | IGFBP7 | cell adhesion [GO:0007155]; cellular response to hormone stimulus [GO:0032870]; embryo implantation [GO:0007566]; negative regulation of cell population proliferation [GO:0008285]; regulation of cell growth [GO:0001558]; regulation of signal transduction [GO:0009966]; regulation of steroid biosynthetic process [GO:0050810]; response to cortisol [GO:0051414]; response to retinoic acid [GO:0032526] | collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] | insulin-like growth factor binding [GO:0005520] | 97336.77163714144 | -0.360186874202269 | 0.0693945308126568 | 0.220027650578911 |
| Q6UVK1 | Q6UVK1 | CSPG4_HUMAN | Chondroitin sulfate proteoglycan 4 (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan) | CSPG4 | angiogenesis [GO:0001525]; glial cell migration [GO:0008347]; intracellular signal transduction [GO:0035556]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; ruffle assembly [GO:0097178]; substrate-dependent cell migration [GO:0006929]; tissue remodeling [GO:0048771] | apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; Golgi lumen [GO:0005796]; lamellipodium membrane [GO:0031258]; lysosomal lumen [GO:0043202]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ruffle [GO:0001726] | coreceptor activity [GO:0015026]; protein kinase binding [GO:0019901] | 5005.5773387389 | 0.812684846192004 | 0.069511475661086 | 0.220274519906287 |
| Q9BRT6 | Q9BRT6 | LLPH_HUMAN | Protein LLP homolog (Protein LAPS18-like) | LLPH | dendrite extension [GO:0097484]; positive regulation of dendritic spine development [GO:0060999] | chromosome [GO:0005694]; nucleolus [GO:0005730] | basal RNA polymerase II transcription machinery binding [GO:0001099]; RNA binding [GO:0003723] | 28958.20093289685 | 0.264229983790262 | 0.0695890205845842 | 0.220274519906287 |
| Q15165 | Q15165 | PON2_HUMAN | Serum paraoxonase/arylesterase 2 (PON 2) (EC 3.1.1.2) (EC 3.1.1.81) (Aromatic esterase 2) (A-esterase 2) (Serum aryldialkylphosphatase 2) | PON2 | aromatic compound catabolic process [GO:0019439]; response to toxic substance [GO:0009636] | extracellular region [GO:0005576]; plasma membrane [GO:0005886] | acyl-L-homoserine-lactone lactonohydrolase activity [GO:0102007]; arylesterase activity [GO:0004064]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] | 16573.673400861502 | 0.315996355164751 | 0.0695786236199538 | 0.220274519906287 |
| O43583 | O43583 | DENR_HUMAN | Density-regulated protein (DRP) (Protein DRP1) (Smooth muscle cell-associated protein 3) (SMAP-3) | DENR | formation of translation preinitiation complex [GO:0001731]; IRES-dependent viral translational initiation [GO:0075522]; ribosome disassembly [GO:0032790]; translation reinitiation [GO:0002188] | mRNA binding [GO:0003729]; translation initiation factor activity [GO:0003743] | 42299.73102832789 | 0.183733532948627 | 0.0697519411900507 | 0.220666945160708 | |
| P82094 | P82094 | TMF1_HUMAN | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | TMF1 | acrosome assembly [GO:0001675]; androgen receptor signaling pathway [GO:0030521]; defense response to bacterium [GO:0042742]; epithelial cell apoptotic process [GO:1904019]; flagellated sperm motility [GO:0030317]; Leydig cell differentiation [GO:0033327]; luteinizing hormone secretion [GO:0032275]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of gene expression [GO:0010629]; positive regulation of cytokine production [GO:0001819]; positive regulation of testosterone secretion [GO:2000845]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of proteasomal protein catabolic process [GO:0061136]; spermatid nucleus differentiation [GO:0007289] | cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleus [GO:0005634] | DNA binding [GO:0003677]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor coactivator activity [GO:0030374] | 6582.93311336239 | 0.2718513508241 | 0.0699819443362776 | 0.221271036054324 |
| Q8NBJ7 | Q8NBJ7 | SUMF2_HUMAN | Inactive C-alpha-formylglycine-generating enzyme 2 (Paralog of formylglycine-generating enzyme) (pFGE) (Sulfatase-modifying factor 2) | SUMF2 | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788] | identical protein binding [GO:0042802]; metal ion binding [GO:0046872] | 81446.12272155295 | 0.268394631670902 | 0.0704972086562083 | 0.222651719200711 | |
| Q71RC2 | Q71RC2 | LARP4_HUMAN | La-related protein 4 (La ribonucleoprotein domain family member 4) | LARP4 | cytoskeleton organization [GO:0007010]; positive regulation of translation [GO:0045727]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of cell morphogenesis [GO:0022604]; translation [GO:0006412] | cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020] | mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; RNA binding [GO:0003723] | 12517.8278184635 | 0.282297745672658 | 0.070588001431054 | 0.222814270812452 |
| Q96PC3 | Q96PC3 | AP1S3_HUMAN | AP-1 complex subunit sigma-3 (Adaptor protein complex AP-1 subunit sigma-1C) (Adaptor-related protein complex 1 subunit sigma-1C) (Clathrin assembly protein complex 1 sigma-1C small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1C subunit) (Sigma 1C subunit of AP-1 clathrin) (Sigma-adaptin 1C) (Sigma1C-adaptin) | AP1S3 | intracellular protein transport [GO:0006886]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; protein targeting [GO:0006605]; vesicle-mediated transport [GO:0016192] | AP-1 adaptor complex [GO:0030121]; clathrin-coated pit [GO:0005905]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588] | clathrin adaptor activity [GO:0035615] | 7847.41012608003 | 0.343687833935722 | 0.0707384088960502 | 0.223164713143107 |
| P30837 | P30837 | AL1B1_HUMAN | Aldehyde dehydrogenase X, mitochondrial (EC 1.2.1.3) (Aldehyde dehydrogenase 5) (Aldehyde dehydrogenase family 1 member B1) | ALDH1B1 | carbohydrate metabolic process [GO:0005975]; ethanol catabolic process [GO:0006068] | cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] | aldehyde dehydrogenase (NAD+) activity [GO:0004029]; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity [GO:0043878]; NAD binding [GO:0051287] | 9017.075022588 | -0.270823538058405 | 0.0708645970094715 | 0.223314130509269 |
| Q9NQG5 | Q9NQG5 | RPR1B_HUMAN | Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor) | RPRD1B | mRNA 3'-end processing [GO:0031124]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle process [GO:0010564]; RNA polymerase II promoter clearance [GO:0001111] | nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription preinitiation complex [GO:0097550] | identical protein binding [GO:0042802]; RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II complex binding [GO:0000993] | 17491.085185093652 | 0.31325437560431 | 0.0708299374961891 | 0.223314130509269 |
| Q9H3S7 | Q9H3S7 | PTN23_HUMAN | Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) | PTPN23 | cilium assembly [GO:0060271]; dephosphorylation [GO:0016311]; early endosome to late endosome transport [GO:0045022]; endocytic recycling [GO:0032456]; negative regulation of epithelial cell migration [GO:0010633]; positive regulation of adherens junction organization [GO:1903393]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of homophilic cell adhesion [GO:1903387]; positive regulation of Wnt protein secretion [GO:0061357]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162] | ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725] | 9762.674218037286 | -0.274759105161949 | 0.0709677537000378 | 0.223514892976328 |
| P09668 | P09668 | CATH_HUMAN | Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H (EC 3.4.22.16); Cathepsin H heavy chain; Cathepsin H light chain] | CTSH | adaptive immune response [GO:0002250]; antigen processing and presentation [GO:0019882]; bradykinin catabolic process [GO:0010815]; cellular response to thyroid hormone stimulus [GO:0097067]; dichotomous subdivision of terminal units involved in lung branching [GO:0060448]; ERK1 and ERK2 cascade [GO:0070371]; immune response [GO:0006955]; immune response-regulating signaling pathway [GO:0002764]; membrane protein proteolysis [GO:0033619]; metanephros development [GO:0001656]; negative regulation of apoptotic process [GO:0043066]; neuropeptide catabolic process [GO:0010813]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidase activity [GO:0010952]; protein destabilization [GO:0031648]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; response to retinoic acid [GO:0032526]; surfactant homeostasis [GO:0043129]; T cell mediated cytotoxicity [GO:0001913]; zymogen activation [GO:0031638] | alveolar lamellar body [GO:0097208]; collagen-containing extracellular matrix [GO:0062023]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; multivesicular body lumen [GO:0097486]; secretory granule lumen [GO:0034774]; tertiary granule lumen [GO:1904724] | aminopeptidase activity [GO:0004177]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; endopeptidase activity [GO:0004175]; HLA-A specific activating MHC class I receptor activity [GO:0030108]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; thyroid hormone binding [GO:0070324] | 11084.972924796799 | 1.29889878102213 | 0.0715045468689141 | 0.224955448394929 |
| P19256 | P19256 | LFA3_HUMAN | Lymphocyte function-associated antigen 3 (Ag3) (Surface glycoprotein LFA-3) (CD antigen CD58) | CD58 | cell-cell adhesion [GO:0098609]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; heterotypic cell-cell adhesion [GO:0034113]; positive regulation of interleukin-8 production [GO:0032757] | cell surface [GO:0009986]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] | signaling receptor binding [GO:0005102] | 29337.5568200595 | 0.637827671389054 | 0.0715571372308715 | 0.224995970893517 |
| Q9ULX9 | Q9ULX9 | MAFF_HUMAN | Transcription factor MafF (U-Maf) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog F) | MAFF | in utero embryonic development [GO:0001701]; negative regulation of transcription by RNA polymerase II [GO:0000122]; parturition [GO:0007567]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of epidermal cell differentiation [GO:0045604]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914] | chromatin [GO:0000785]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] | DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837] | 5750.84301841473 | 0.534079208663972 | 0.0721083346380979 | 0.226352257096655 |
| P51970 | P51970 | NDUA8_HUMAN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (Complex I-19kD) (CI-19kD) (Complex I-PGIV) (CI-PGIV) (NADH-ubiquinone oxidoreductase 19 kDa subunit) | NDUFA8 | aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776] | mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739] | NADH dehydrogenase (ubiquinone) activity [GO:0008137]; protein-containing complex binding [GO:0044877] | 15432.3252433446 | 0.296948487191887 | 0.0723682045161755 | 0.227042218598367 |
| Q9NUL3 | Q9NUL3 | STAU2_HUMAN | Double-stranded RNA-binding protein Staufen homolog 2 | STAU2 | anterograde dendritic transport of messenger ribonucleoprotein complex [GO:0098964]; cellular response to oxidative stress [GO:0034599]; eye morphogenesis [GO:0048592]; germ cell development [GO:0007281]; intracellular mRNA localization [GO:0008298]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of synapse assembly [GO:0051965]; protein localization to synapse [GO:0035418]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of filopodium assembly [GO:0051489] | axon [GO:0030424]; cytoplasmic stress granule [GO:0010494]; dendrite cytoplasm [GO:0032839]; dendritic shaft [GO:0043198]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; messenger ribonucleoprotein complex [GO:1990124]; microtubule [GO:0005874]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] | double-stranded RNA binding [GO:0003725]; Hsp70 protein binding [GO:0030544]; kinesin binding [GO:0019894]; mitogen-activated protein kinase binding [GO:0051019]; mRNA binding [GO:0003729]; ribosome binding [GO:0043022]; RNA binding [GO:0003723] | 8697.646029661159 | 0.169574438140423 | 0.072705245886026 | 0.227721350575027 |
| Q8NCW5 | Q8NCW5 | NNRE_HUMAN | NAD(P)H-hydrate epimerase (EC 5.1.99.6) (Apolipoprotein A-I-binding protein) (AI-BP) (NAD(P)HX epimerase) (NAXE) (YjeF N-terminal domain-containing protein 1) (YjeF_N1) | NAXE | lipid transport [GO:0006869]; membrane raft distribution [GO:0031580]; negative regulation of angiogenesis [GO:0016525]; nicotinamide nucleotide metabolic process [GO:0046496]; regulation of cholesterol efflux [GO:0010874]; sprouting angiogenesis [GO:0002040] | cell body [GO:0044297]; cilium [GO:0005929]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759] | identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; NADHX epimerase activity [GO:0052856]; NADPHX epimerase activity [GO:0052857]; nucleotide binding [GO:0000166] | 31579.80890857575 | -0.196129947785541 | 0.0729665383368832 | 0.228287358485246 |
| P30101 | P30101 | PDIA3_HUMAN | Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60) | PDIA3 | adaptive immune response [GO:0002250]; cellular response to interleukin-7 [GO:0098761]; extrinsic apoptotic signaling pathway [GO:0097191]; peptide antigen assembly with MHC class I protein complex [GO:0002502]; platelet aggregation [GO:0070527]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; response to endoplasmic reticulum stress [GO:0034976] | cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; melanosome [GO:0042470]; MHC class I peptide loading complex [GO:0042824]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; recycling endosome membrane [GO:0055038]; Tapasin-ERp57 complex [GO:0061779] | cysteine-type endopeptidase activity [GO:0004197]; disulfide oxidoreductase activity [GO:0015036]; identical protein binding [GO:0042802]; phospholipase C activity [GO:0004629]; protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035]; RNA binding [GO:0003723] | 488415.2540379555 | 0.172988274685633 | 0.0731140632999923 | 0.228496570688227 |
| O14787 | O14787 | TNPO2_HUMAN | Transportin-2 (Karyopherin beta-2b) | TNPO2 | protein import into nucleus [GO:0006606] | cytoplasm [GO:0005737]; nucleus [GO:0005634] | nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; small GTPase binding [GO:0031267] | 6271.725259585875 | -0.555004507113277 | 0.0731137175060376 | 0.228496570688227 |
| P62081 | P62081 | RS7_HUMAN | Small ribosomal subunit protein eS7 (40S ribosomal protein S7) | RPS7 | cytoplasmic translation [GO:0002181]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; neural crest cell differentiation [GO:0014033]; neural tube closure [GO:0001843]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; protein stabilization [GO:0050821]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412] | 90S preribosome [GO:0030686]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]; synapse [GO:0045202] | mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948] | 136634.89397968352 | 0.253460743056908 | 0.0732412483037613 | 0.228767868185839 |
| Q9BYN8 | Q9BYN8 | RT26_HUMAN | Small ribosomal subunit protein mS26 (28S ribosomal protein S13, mitochondrial) (MRP-S13) (S13mt) (28S ribosomal protein S26, mitochondrial) (MRP-S26) (S26mt) | MRPS26 | mitochondrial translation [GO:0032543] | mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] | RNA binding [GO:0003723] | 17639.771906359652 | 0.346258221877185 | 0.0733043207838401 | 0.228838722623272 |
| P12036 | P12036 | NFH_HUMAN | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | NEFH | axon development [GO:0061564]; axonogenesis [GO:0007409]; cell projection assembly [GO:0030031]; cellular response to leukemia inhibitory factor [GO:1990830]; intermediate filament bundle assembly [GO:0045110]; microtubule cytoskeleton organization [GO:0000226]; neurofilament bundle assembly [GO:0033693]; neurofilament cytoskeleton organization [GO:0060052]; peripheral nervous system neuron axonogenesis [GO:0048936]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of organelle transport along microtubule [GO:1902513] | axon [GO:0030424]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; neurofibrillary tangle [GO:0097418]; neurofilament [GO:0005883]; postsynaptic density [GO:0014069]; postsynaptic intermediate filament cytoskeleton [GO:0099160]; Schaffer collateral - CA1 synapse [GO:0098685] | dynein complex binding [GO:0070840]; kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of postsynaptic intermediate filament cytoskeleton [GO:0099184] | 3085.9820918320947 | 0.234616408933783 | 0.0733740864727578 | 0.228930382133616 |
| Q9NUL5 | Q9NUL5 | SHFL_HUMAN | Shiftless antiviral inhibitor of ribosomal frameshifting protein (SFL) (SHFL) (Interferon-regulated antiviral protein) (IRAV) (Repressor of yield of DENV protein) (RyDEN) | SHFL | defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of translational frameshifting [GO:2001125]; negative regulation of viral genome replication [GO:0045071]; regulation of translational termination [GO:0006449]; response to interferon-beta [GO:0035456]; response to type I interferon [GO:0034340]; response to type II interferon [GO:0034341]; response to type III interferon [GO:0034342]; viral translational frameshifting [GO:0075523] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932] | identical protein binding [GO:0042802]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825] | 11075.59969571525 | 0.369243888681376 | 0.0743817742773238 | 0.231946563064955 |
| Q9H270 | Q9H270 | VPS11_HUMAN | Vacuolar protein sorting-associated protein 11 homolog (hVPS11) (RING finger protein 108) | VPS11 | autophagy [GO:0006914]; endosomal vesicle fusion [GO:0034058]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; organelle fusion [GO:0048284]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein ubiquitination [GO:0016567]; regulation of organelle assembly [GO:1902115]; regulation of protein stability [GO:0031647]; regulation of SNARE complex assembly [GO:0035542]; vacuole organization [GO:0007033]; vesicle docking involved in exocytosis [GO:0006904] | autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; endosome membrane [GO:0010008]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764] | metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; protein domain specific binding [GO:0019904]; protein-macromolecule adaptor activity [GO:0030674]; syntaxin binding [GO:0019905]; ubiquitin protein ligase activity [GO:0061630] | 9853.776912128349 | -0.254902773093894 | 0.074422670605734 | 0.231946563064955 |
| Q6UXD5 | Q6UXD5 | SE6L2_HUMAN | Seizure 6-like protein 2 | SEZ6L2 | regulation of protein kinase C signaling [GO:0090036]; synapse maturation [GO:0060074] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] | 5862.730592691385 | -1.60431735502472 | 0.0745655527974585 | 0.232264113331721 | |
| Q04760 | Q04760 | LGUL_HUMAN | Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase) | GLO1 | carbohydrate metabolic process [GO:0005975]; glutathione metabolic process [GO:0006749]; methylglyoxal metabolic process [GO:0009438]; negative regulation of apoptotic process [GO:0043066]; osteoclast differentiation [GO:0030316]; regulation of transcription by RNA polymerase II [GO:0006357] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] | lactoylglutathione lyase activity [GO:0004462]; zinc ion binding [GO:0008270] | 152792.168845914 | 0.288622217360622 | 0.0750162383003633 | 0.233539563851571 |
| O14763 | O14763 | TR10B_HUMAN | Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262) | TNFRSF10B | activation of NF-kappaB-inducing kinase activity [GO:0007250]; apoptotic process [GO:0006915]; cell surface receptor signaling pathway [GO:0007166]; cellular response to mechanical stimulus [GO:0071260]; defense response to tumor cell [GO:0002357]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of apoptotic process [GO:0042981]; response to endoplasmic reticulum stress [GO:0034976]; TRAIL-activated apoptotic signaling pathway [GO:0036462] | cell surface [GO:0009986]; plasma membrane [GO:0005886] | signaling receptor activity [GO:0038023]; TRAIL binding [GO:0045569]; TRAIL receptor activity [GO:0036463] | 27706.0037968131 | 0.34507813342016 | 0.0755425786712261 | 0.235049011944628 |
| P16591 | P16591 | FER_HUMAN | Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer) | FER | actin cytoskeleton organization [GO:0030036]; adherens junction assembly [GO:0034333]; adherens junction disassembly [GO:0120179]; cell adhesion [GO:0007155]; cell-cell adhesion mediated by cadherin [GO:0044331]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cellular response to reactive oxygen species [GO:0034614]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; diapedesis [GO:0050904]; extracellular matrix-cell signaling [GO:0035426]; Fc-epsilon receptor signaling pathway [GO:0038095]; germ cell development [GO:0007281]; insulin receptor signaling pathway [GO:0008286]; interleukin-6-mediated signaling pathway [GO:0070102]; intracellular signal transduction [GO:0035556]; Kit signaling pathway [GO:0038109]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of mast cell activation involved in immune response [GO:0033007]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of fibroblast migration [GO:0010762]; regulation of lamellipodium assembly [GO:0010591]; regulation of mast cell degranulation [GO:0043304]; regulation of protein phosphorylation [GO:0001932]; response to lipopolysaccharide [GO:0032496]; response to platelet-derived growth factor [GO:0036119]; seminiferous tubule development [GO:0072520]; Sertoli cell development [GO:0060009]; substrate adhesion-dependent cell spreading [GO:0034446]; tyrosine phosphorylation of STAT protein [GO:0007260] | adherens junction [GO:0005912]; cell cortex [GO:0005938]; cell projection [GO:0042995]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634] | ATP binding [GO:0005524]; epidermal growth factor receptor binding [GO:0005154]; lipid binding [GO:0008289]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein phosphatase 1 binding [GO:0008157]; protein tyrosine kinase activity [GO:0004713] | 7206.77076651836 | -0.378482921749149 | 0.0756881070842206 | 0.235372565718548 |
| Q14839 | Q14839 | CHD4_HUMAN | Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.12) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) | CHD4 | chromatin remodeling [GO:0006338]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736]; regulation of synapse assembly [GO:0051963]; terminal button organization [GO:0072553] | centrosome [GO:0005813]; cerebellar granule cell to Purkinje cell synapse [GO:0150048]; chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; site of DNA damage [GO:0090734] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coregulator binding [GO:0001221]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270] | 7365.64619251857 | -0.236731166756791 | 0.0757576726643292 | 0.235459667205754 |
| Q9UKK9 | Q9UKK9 | NUDT5_HUMAN | ADP-sugar pyrophosphatase (EC 3.6.1.13) (8-oxo-dGDP phosphatase) (EC 3.6.1.58) (Nuclear ATP-synthesis protein NUDIX5) (EC 2.7.7.96) (Nucleoside diphosphate-linked moiety X motif 5) (Nudix motif 5) (hNUDT5) (YSA1H) | NUDT5 | ATP generation from poly-ADP-D-ribose [GO:1990966]; chromatin remodeling [GO:0006338]; D-ribose catabolic process [GO:0019303]; nucleobase-containing small molecule metabolic process [GO:0055086]; nucleoside phosphate metabolic process [GO:0006753]; nucleotide metabolic process [GO:0009117]; ribonucleoside diphosphate catabolic process [GO:0009191]; ribose phosphate metabolic process [GO:0019693] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] | 8-oxo-dGDP phosphatase activity [GO:0044715]; 8-oxo-GDP phosphatase activity [GO:0044716]; ADP-ribose diphosphatase activity [GO:0047631]; ADP-sugar diphosphatase activity [GO:0019144]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleotidyltransferase activity [GO:0016779]; protein homodimerization activity [GO:0042803]; snoRNA binding [GO:0030515] | 57598.2597076682 | 0.230612283994282 | 0.0758981809674317 | 0.23576704679905 |
| Q96QD8 | Q96QD8 | S38A2_HUMAN | Sodium-coupled neutral amino acid symporter 2 (Amino acid transporter A2) (Protein 40-9-1) (Solute carrier family 38 member 2) (System A amino acid transporter 2) (System A transporter 1) (System N amino acid transporter 2) | SLC38A2 | alanine transport [GO:0032328]; amino acid import [GO:0043090]; amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; cellular response to amino acid starvation [GO:0034198]; cellular response to arsenite(3-) [GO:1903841]; cellular response to mechanical stimulus [GO:0071260]; cerebral cortex development [GO:0021987]; female pregnancy [GO:0007565]; glutamine transport [GO:0006868]; glycine betaine transport [GO:0031460]; L-glutamine import across plasma membrane [GO:1903803]; L-proline import across plasma membrane [GO:1904271]; L-serine import across plasma membrane [GO:1903812]; L-serine transport [GO:0015825]; neurotransmitter transport [GO:0006836]; neutral amino acid transport [GO:0015804]; positive regulation of gene expression [GO:0010628]; positive regulation of RNA splicing [GO:0033120]; proline transport [GO:0015824]; regulation of cellular response to stress [GO:0080135]; regulation of glutamate secretion, neurotransmission [GO:1903294]; response to muscle activity [GO:0014850]; transport across blood-brain barrier [GO:0150104] | axon [GO:0030424]; brush border [GO:0005903]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383] | acidic amino acid transmembrane transporter activity [GO:0015172]; alanine:sodium symporter activity [GO:0015655]; amino acid transmembrane transporter activity [GO:0015171]; amino acid:sodium symporter activity [GO:0005283]; L-glutamine transmembrane transporter activity [GO:0015186]; L-serine transmembrane transporter activity [GO:0015194]; neutral L-amino acid:sodium symporter activity [GO:0005295]; proline:sodium symporter activity [GO:0005298] | 26029.01110274245 | -0.164187941816492 | 0.0762987782002735 | 0.236751849552437 |
| Q9HCJ6 | Q9HCJ6 | VAT1L_HUMAN | Synaptic vesicle membrane protein VAT-1 homolog-like (EC 1.-.-.-) | VAT1L | oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270] | 9247.603458236636 | -0.297218397761374 | 0.0762874964557051 | 0.236751849552437 | ||
| Q13263 | Q13263 | TIF1B_HUMAN | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | TRIM28 | chromatin organization [GO:0006325]; convergent extension involved in axis elongation [GO:0060028]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epithelial to mesenchymal transition [GO:0001837]; genomic imprinting [GO:0071514]; innate immune response [GO:0045087]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA methylation-dependent heterochromatin formation [GO:0090309]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein import into nucleus [GO:0042307]; post-fertilization epigenetic regulation of gene expression [GO:0043045]; protein sumoylation [GO:0016925]; suppression of viral release by host [GO:0044790] | euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575] | chromatin binding [GO:0003682]; chromo shadow domain binding [GO:0070087]; DNA binding [GO:0003677]; Krueppel-associated box domain binding [GO:0035851]; promoter-specific chromatin binding [GO:1990841]; protein kinase activity [GO:0004672]; RNA binding [GO:0003723]; SUMO transferase activity [GO:0019789]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] | 59012.547088828855 | -0.0978908801030166 | 0.0763914664050984 | 0.236909714642193 |
| P49588 | P49588 | SYAC_HUMAN | Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Renal carcinoma antigen NY-REN-42) | AARS1 | alanyl-tRNA aminoacylation [GO:0006419]; cerebellar Purkinje cell layer development [GO:0021680]; negative regulation of neuron apoptotic process [GO:0043524]; neuromuscular process controlling balance [GO:0050885]; neuron apoptotic process [GO:0051402]; regulation of cytoplasmic translational fidelity [GO:0140018]; tRNA aminoacylation for protein translation [GO:0006418]; tRNA modification [GO:0006400]; tRNA processing [GO:0008033] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739] | alanine-tRNA ligase activity [GO:0004813]; amino acid binding [GO:0016597]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; Ser-tRNA(Ala) hydrolase activity [GO:0002196]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270] | 58248.59735444535 | -0.142159687065425 | 0.0768818858566638 | 0.238300199816114 |
| Q9UNH6 | Q9UNH6 | SNX7_HUMAN | Sorting nexin-7 | SNX7 | endocytic recycling [GO:0032456]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagosome assembly [GO:2000786]; protein transport [GO:0015031]; reticulophagy [GO:0061709] | early endosome [GO:0005769]; early endosome membrane [GO:0031901]; phagophore assembly site [GO:0000407] | phosphatidylinositol binding [GO:0035091] | 12445.80095186 | -0.437664322079546 | 0.0775627592375207 | 0.240227893834441 |
| Q96Q11 | Q96Q11 | TRNT1_HUMAN | CCA tRNA nucleotidyltransferase 1, mitochondrial (EC 2.7.7.72) (Mitochondrial tRNA nucleotidyl transferase, CCA-adding) (mt CCA-adding enzyme) (mt tRNA CCA-diphosphorylase) (mt tRNA CCA-pyrophosphorylase) (mt tRNA adenylyltransferase) | TRNT1 | mitochondrial tRNA 3'-end processing [GO:1990180]; rescue of stalled ribosome [GO:0072344]; tRNA 3'-end processing [GO:0042780]; tRNA 3'-terminal CCA addition [GO:0001680]; tRNA surveillance [GO:0106354] | cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | 5'-3' RNA polymerase activity [GO:0034062]; ATP binding [GO:0005524]; CCA tRNA nucleotidyltransferase activity [GO:0004810]; CCACCA tRNA nucleotidyltransferase activity [GO:0160016]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049] | 19145.7746557742 | 0.244174294379267 | 0.077818484429383 | 0.240808046300865 |
| Q5EBL4 | Q5EBL4 | RIPL1_HUMAN | RILP-like protein 1 (Rab-interacting lysosomal-like protein 1) | RILPL1 | cilium assembly [GO:0060271]; epithelial cell morphogenesis [GO:0003382]; nitric oxide mediated signal transduction [GO:0007263]; protein transport from ciliary membrane to plasma membrane [GO:1903445] | centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] | dynein light intermediate chain binding [GO:0051959]; protein dimerization activity [GO:0046983]; small GTPase binding [GO:0031267] | 17601.194928846948 | 0.244440030200284 | 0.0780241637545931 | 0.2411823642956 |
| Q92542 | Q92542 | NICA_HUMAN | Nicastrin | NCSTN | adult behavior [GO:0030534]; amyloid precursor protein biosynthetic process [GO:0042983]; amyloid precursor protein catabolic process [GO:0042987]; amyloid precursor protein metabolic process [GO:0042982]; amyloid-beta formation [GO:0034205]; cellular response to calcium ion [GO:0071277]; central nervous system myelination [GO:0022010]; cerebellum development [GO:0021549]; dopamine receptor signaling pathway [GO:0007212]; epithelial cell proliferation [GO:0050673]; glutamate receptor signaling pathway [GO:0007215]; learning or memory [GO:0007611]; membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; myeloid cell homeostasis [GO:0002262]; neuron apoptotic process [GO:0051402]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; positive regulation of amyloid precursor protein biosynthetic process [GO:0042986]; positive regulation of catalytic activity [GO:0043085]; positive regulation of endopeptidase activity [GO:0010950]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of long-term synaptic potentiation [GO:1900271]; short-term synaptic potentiation [GO:1990926]; T cell proliferation [GO:0042098] | azurophil granule membrane [GO:0035577]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; gamma-secretase complex [GO:0070765]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; sarcolemma [GO:0042383]; synaptic vesicle [GO:0008021] | aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; ATPase binding [GO:0051117]; growth factor receptor binding [GO:0070851]; protein-macromolecule adaptor activity [GO:0030674] | 21469.21989798115 | 0.194203782942075 | 0.0781333410374282 | 0.241188897939284 |
| Q13610 | Q13610 | PWP1_HUMAN | Periodic tryptophan protein 1 homolog (Keratinocyte protein IEF SSP 9502) | PWP1 | DNA-templated transcription [GO:0006351]; negative regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033140]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; rRNA processing [GO:0006364] | chromosome [GO:0005694]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleus [GO:0005634] | H4K20me3 modified histone binding [GO:1990889]; histone chaperone activity [GO:0140713] | 13808.0964256237 | 0.209051073563514 | 0.078154397567336 | 0.241188897939284 |
| Q13433 | Q13433 | S39A6_HUMAN | Zinc transporter ZIP6 (Estrogen-regulated protein LIV-1) (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6) | SLC39A6 | epithelial to mesenchymal transition [GO:0001837]; intracellular zinc ion homeostasis [GO:0006882]; lymphocyte activation [GO:0046649]; T cell receptor signaling pathway [GO:0050852]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577] | apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; lamellipodium membrane [GO:0031258]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] | monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385] | 10302.74318918155 | 0.352926273384179 | 0.0781385504923278 | 0.241188897939284 |
| P56537 | P56537 | IF6_HUMAN | Eukaryotic translation initiation factor 6 (eIF-6) (B(2)GCN homolog) (B4 integrin interactor) (CAB) (p27(BBP)) | EIF6 | assembly of large subunit precursor of preribosome [GO:1902626]; cytosolic ribosome assembly [GO:0042256]; maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; positive regulation of translation [GO:0045727]; regulation of fatty acid biosynthetic process [GO:0042304]; regulation of glycolytic process [GO:0006110]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of reactive oxygen species metabolic process [GO:2000377]; response to insulin [GO:0032868]; ribosomal subunit export from nucleus [GO:0000054] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamin filament [GO:0005638]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, large subunit precursor [GO:0030687]; synapse [GO:0045202] | ribosomal large subunit binding [GO:0043023]; ribosome binding [GO:0043022]; translation initiation factor activity [GO:0003743] | 87019.37317768115 | -0.218412985321505 | 0.0792173047948926 | 0.244203073431916 |
| Q13439 | Q13439 | GOGA4_HUMAN | Golgin subfamily A member 4 (256 kDa golgin) (Golgin-245) (Protein 72.1) (Trans-Golgi p230) | GOLGA4 | Golgi to plasma membrane protein transport [GO:0043001]; Golgi vesicle transport [GO:0048193]; positive regulation of axon extension [GO:0045773]; vesicle-mediated transport [GO:0016192] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] | GTPase binding [GO:0051020]; small GTPase binding [GO:0031267] | 13491.99125729105 | -0.215502944751566 | 0.0797279036699815 | 0.245643448718932 |
| Q9NS93 | Q9NS93 | TM7S3_HUMAN | Transmembrane 7 superfamily member 3 (Seven span transmembrane protein) | TM7SF3 | cellular response to unfolded protein [GO:0034620]; negative regulation of programmed cell death [GO:0043069]; positive regulation of insulin secretion [GO:0032024] | extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] | 16902.18167504575 | 0.190926003613047 | 0.0799531920630132 | 0.246203688167953 | |
| O95208 | O95208 | EPN2_HUMAN | Epsin-2 (EPS-15-interacting protein 2) | EPN2 | endocytosis [GO:0006897]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; positive regulation of Notch signaling pathway [GO:0045747] | clathrin vesicle coat [GO:0030125]; cytosol [GO:0005829]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] | cadherin binding [GO:0045296]; clathrin binding [GO:0030276]; phospholipid binding [GO:0005543] | 15845.965706997798 | 0.376953377431466 | 0.0800944736237511 | 0.246370948725393 |
| Q13107 | Q13107 | UBP4_HUMAN | Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Ubiquitous nuclear protein homolog) | USP4 | negative regulation of protein ubiquitination [GO:0031397]; positive regulation of TORC1 signaling [GO:1904263]; protein deubiquitination [GO:0016579]; protein localization to cell surface [GO:0034394]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647]; spliceosomal tri-snRNP complex assembly [GO:0000244] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosome [GO:0005764]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | adenosine receptor binding [GO:0031685]; cysteine-type deubiquitinase activity [GO:0004843]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] | 6670.869531629315 | -0.251035107728889 | 0.0802426178775886 | 0.246692714538479 |
| O43639 | O43639 | NCK2_HUMAN | Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta) | NCK2 | actin filament organization [GO:0007015]; cell migration [GO:0016477]; dendritic spine development [GO:0060996]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; immunological synapse formation [GO:0001771]; lamellipodium assembly [GO:0030032]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:1903912]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of peptidyl-serine dephosphorylation [GO:1902310]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation in response to endoplasmic reticulum stress [GO:0036493]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165]; T cell activation [GO:0042110] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; postsynaptic density [GO:0014069]; vesicle membrane [GO:0012506] | cytoskeletal anchor activity [GO:0008093]; phosphotyrosine residue binding [GO:0001784]; protein-containing complex binding [GO:0044877]; receptor tyrosine kinase binding [GO:0030971]; scaffold protein binding [GO:0097110]; signaling adaptor activity [GO:0035591]; signaling receptor complex adaptor activity [GO:0030159] | 6438.747110957011 | -0.39964032241227 | 0.0804014333245052 | 0.246913019629619 |
| Q8NC96 | Q8NC96 | NECP1_HUMAN | Adaptin ear-binding coat-associated protein 1 (NECAP endocytosis-associated protein 1) (NECAP-1) | NECAP1 | endocytosis [GO:0006897]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] | clathrin vesicle coat [GO:0030125]; clathrin-coated pit [GO:0005905]; cytosol [GO:0005829]; plasma membrane [GO:0005886] | 17363.80711841855 | 0.278040643458299 | 0.0805891291991777 | 0.247355366220228 | |
| Q07955 | Q07955 | SRSF1_HUMAN | Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit) | SRSF1 | alternative mRNA splicing, via spliceosome [GO:0000380]; liver regeneration [GO:0097421]; mRNA 5'-splice site recognition [GO:0000395]; mRNA processing [GO:0006397]; mRNA splice site recognition [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transport [GO:0051028]; oligodendrocyte differentiation [GO:0048709]; positive regulation of RNA splicing [GO:0033120]; regulation of RNA splicing [GO:0043484] | catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; nuclear envelope [GO:0005635]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | DNA topoisomerase binding [GO:0044547]; mRNA binding [GO:0003729]; protein kinase B binding [GO:0043422]; RNA binding [GO:0003723] | 73155.55502867876 | 0.230239062655576 | 0.0806378604198039 | 0.247370935104824 |
| O75674 | O75674 | TM1L1_HUMAN | TOM1-like protein 1 (Src-activating and signaling molecule protein) (Target of Myb-like protein 1) | TOM1L1 | activation of protein kinase activity [GO:0032147]; negative regulation of mitotic nuclear division [GO:0045839]; positive regulation of protein autophosphorylation [GO:0031954]; protein transport [GO:0015031]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi stack [GO:0005795]; lysosome [GO:0005764]; membrane [GO:0016020] | clathrin binding [GO:0030276]; phosphatidylinositol binding [GO:0035091]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]; ubiquitin binding [GO:0043130] | 18653.54332884675 | 0.294946133147484 | 0.0807706477351055 | 0.247644204581768 |
| Q92541 | Q92541 | RTF1_HUMAN | RNA polymerase-associated protein RTF1 homolog | RTF1 | blastocyst growth [GO:0001832]; chromatin organization [GO:0006325]; endodermal cell fate commitment [GO:0001711]; negative regulation of transcription by RNA polymerase II [GO:0000122]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368]; Wnt signaling pathway [GO:0016055] | Cdc73/Paf1 complex [GO:0016593]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] | RNA binding [GO:0003723]; RNA polymerase II C-terminal domain phosphoserine binding [GO:1990269]; single-stranded DNA binding [GO:0003697] | 10451.65593070945 | 0.200934196238638 | 0.0809382664510221 | 0.247908885332581 |
| Q5MNZ6 | Q5MNZ6 | WIPI3_HUMAN | WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3) (WD repeat-containing protein 45-like) (WDR45-like protein) (WD repeat-containing protein 45B) (WIPI49-like protein) | WDR45B | autophagosome assembly [GO:0000045]; cellular response to starvation [GO:0009267]; glycophagy [GO:0061723]; nucleophagy [GO:0044804]; protein localization to phagophore assembly site [GO:0034497] | cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; lysosome [GO:0005764]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045] | phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; TSC1-TSC2 complex binding [GO:0062078] | 14383.03786414985 | -0.150223459229349 | 0.0809444825035785 | 0.247908885332581 |
| Q9H0W9 | Q9H0W9 | CK054_HUMAN | Ester hydrolase C11orf54 (EC 3.1.-.-) | C11orf54 | extracellular exosome [GO:0070062]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | hydrolase activity, acting on ester bonds [GO:0016788]; zinc ion binding [GO:0008270] | 2134.28735580793 | 1.08118827095342 | 0.081002543617104 | 0.247952680785798 | |
| P52735 | P52735 | VAV2_HUMAN | Guanine nucleotide exchange factor VAV2 (VAV-2) | VAV2 | angiogenesis [GO:0001525]; cell migration [GO:0016477]; cellular response to xenobiotic stimulus [GO:0071466]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; lamellipodium assembly [GO:0030032]; platelet activation [GO:0030168]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of cell size [GO:0008361]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; small GTPase-mediated signal transduction [GO:0007264]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] | epidermal growth factor receptor binding [GO:0005154]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; phosphotyrosine residue binding [GO:0001784] | 5919.13856669338 | -0.30428667840574 | 0.081402200327137 | 0.24904150488853 |
| Q9UFG5 | Q9UFG5 | CS025_HUMAN | UPF0449 protein C19orf25 | C19orf25 | 13562.58906445345 | -0.38278905706106 | 0.0816387314538024 | 0.24949571327791 | |||
| Q14671 | Q14671 | PUM1_HUMAN | Pumilio homolog 1 (HsPUM) (Pumilio-1) | PUM1 | 3'-UTR-mediated mRNA destabilization [GO:0061158]; adult locomotory behavior [GO:0008344]; miRNA processing [GO:0035196]; mRNA destabilization [GO:0061157]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of RIG-I signaling pathway [GO:1900246]; post-transcriptional gene silencing [GO:0016441]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of cell cycle [GO:0051726]; regulation of chromosome segregation [GO:0051983]; regulation of miRNA-mediated gene silencing [GO:0060964]; regulation of mRNA stability [GO:0043488]; regulation of translation [GO:0006417]; spermatogenesis [GO:0007283]; stem cell differentiation [GO:0048863] | axon [GO:0030424]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932] | miRNA binding [GO:0035198]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723] | 14203.1073415633 | -0.237077167946388 | 0.0816294784707395 | 0.24949571327791 |
| Q9NZD8 | Q9NZD8 | SPG21_HUMAN | Maspardin (Acid cluster protein 33) (Spastic paraplegia 21 autosomal recessive Mast syndrome protein) (Spastic paraplegia 21 protein) | SPG21 | antigen receptor-mediated signaling pathway [GO:0050851] | cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; trans-Golgi network transport vesicle [GO:0030140] | CD4 receptor binding [GO:0042609] | 12298.00007080545 | -0.16814443162294 | 0.0818539608199775 | 0.250018621027489 |
| O43823 | O43823 | AKAP8_HUMAN | A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95) | AKAP8 | cell cycle G2/M phase transition [GO:0044839]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to prostaglandin E stimulus [GO:0071380]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; mitotic chromosome condensation [GO:0007076]; negative regulation of tumor necrosis factor production [GO:0032720]; protein transport [GO:0015031]; signal transduction [GO:0007165] | condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; female pronucleus [GO:0001939]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | double-stranded DNA binding [GO:0003690]; histone deacetylase binding [GO:0042826]; NF-kappaB binding [GO:0051059]; protein kinase A regulatory subunit binding [GO:0034237]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] | 3100.778594907315 | 1.32987182748328 | 0.0827799326344668 | 0.252438696612965 |
| P23284 | P23284 | PPIB_HUMAN | Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) | PPIB | bone development [GO:0060348]; chaperone-mediated protein folding [GO:0061077]; neutrophil chemotaxis [GO:0030593]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation by host of viral process [GO:0044794]; positive regulation of multicellular organism growth [GO:0040018]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; protein stabilization [GO:0050821] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; smooth endoplasmic reticulum [GO:0005790] | cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]; unfolded protein binding [GO:0051082] | 490380.1907627185 | 0.236464573400667 | 0.0827782992537076 | 0.252438696612965 |
| Q9Y6M9 | Q9Y6M9 | NDUB9_HUMAN | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (Complex I-B22) (CI-B22) (LYR motif-containing protein 3) (NADH-ubiquinone oxidoreductase B22 subunit) | NDUFB9 | aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; sensory perception of sound [GO:0007605] | mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739] | NADH dehydrogenase (ubiquinone) activity [GO:0008137] | 17955.183193044897 | 0.385081760004829 | 0.0829311429048743 | 0.252763773910176 |
| Q9GZP4 | Q9GZP4 | PITH1_HUMAN | PITH domain-containing protein 1 | PITHD1 | penetration of cumulus oophorus [GO:0061956]; penetration of zona pellucida [GO:0007341]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of megakaryocyte differentiation [GO:0045654]; regulation of proteasomal protein catabolic process [GO:0061136]; spermatid development [GO:0007286] | cytoplasm [GO:0005737]; nucleus [GO:0005634]; sperm cytoplasmic droplet [GO:0097598] | 14339.7267506026 | 0.239008995548381 | 0.0831331407508769 | 0.253243212631435 | |
| O60264 | O60264 | SMCA5_HUMAN | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) | SMARCA5 | cellular response to leukemia inhibitory factor [GO:1990830]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA-templated transcription initiation [GO:0006352]; heterochromatin formation [GO:0031507]; negative regulation of mitotic chromosome condensation [GO:1905213]; negative regulation of transcription by RNA polymerase I [GO:0016479]; nucleosome assembly [GO:0006334]; positive regulation of DNA replication [GO:0045740]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; rDNA heterochromatin formation [GO:0000183]; regulation of DNA methylation [GO:0044030]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357] | ACF complex [GO:0016590]; B-WICH complex [GO:0110016]; CHRAC [GO:0008623]; chromatin silencing complex [GO:0005677]; condensed chromosome [GO:0000793]; fibrillar center [GO:0001650]; NoRC complex [GO:0090536]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NURF complex [GO:0016589]; pericentric heterochromatin [GO:0005721]; RSF complex [GO:0031213]; site of double-strand break [GO:0035861]; WICH complex [GO:0090535] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393]; histone octamer slider activity [GO:0140751]; nucleosome binding [GO:0031491] | 11305.66438966115 | -0.167619326730682 | 0.0832286012277188 | 0.253397772464403 |
| Q9UGP4 | Q9UGP4 | LIMD1_HUMAN | LIM domain-containing protein 1 | LIMD1 | cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of hippo signaling [GO:0035331]; negative regulation of osteoblast differentiation [GO:0045668]; osteoblast development [GO:0002076]; P-body assembly [GO:0033962]; phosphorylation [GO:0016310]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; regulation of cell shape [GO:0008360]; regulation of DNA-templated transcription [GO:0006355]; response to hypoxia [GO:0001666] | adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; plasma membrane [GO:0005886]; RISC complex [GO:0016442]; transcription regulator complex [GO:0005667] | metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] | 6374.5619064886705 | 0.416196276658731 | 0.0834408292630026 | 0.253907485823938 |
| Q9UK45 | Q9UK45 | LSM7_HUMAN | U6 snRNA-associated Sm-like protein LSm7 | LSM7 | mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process [GO:0000956] | catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; Lsm1-7-Pat1 complex [GO:1990726]; Lsm2-8 complex [GO:0120115]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal tri-snRNP complex [GO:0097526]; U12-type spliceosomal complex [GO:0005689]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688] | U6 snRNA binding [GO:0017070] | 12181.51052959195 | -0.585487670236698 | 0.0838589147744569 | 0.254905907248966 |
| O43164 | O43164 | PJA2_HUMAN | E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2) | PJA2 | inflammatory response [GO:0006954]; innate immune response [GO:0045087]; long-term memory [GO:0007616]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of macrophage activation [GO:0043030]; regulation of protein kinase A signaling [GO:0010738] | centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; intermediate filament cytoskeleton [GO:0045111]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] | metal ion binding [GO:0046872]; protein kinase A catalytic subunit binding [GO:0034236]; protein kinase A regulatory subunit binding [GO:0034237]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] | 4896.95013261042 | 0.262875396467622 | 0.0844218343750856 | 0.256341968686621 |
| P53675 | P53675 | CLH2_HUMAN | Clathrin heavy chain 2 (Clathrin heavy chain on chromosome 22) (CLH-22) | CLTCL1 | anatomical structure morphogenesis [GO:0009653]; intracellular protein transport [GO:0006886]; mitotic cell cycle [GO:0000278]; positive regulation of glucose import [GO:0046326]; receptor-mediated endocytosis [GO:0006898]; retrograde transport, endosome to Golgi [GO:0042147] | clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin complex [GO:0071439]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; coated vesicle [GO:0030135]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; membrane [GO:0016020]; sorting endosome [GO:0097443]; spindle [GO:0005819]; trans-Golgi network [GO:0005802] | clathrin light chain binding [GO:0032051]; structural molecule activity [GO:0005198] | 84874.177282189 | -0.296697759044038 | 0.0846478270433379 | 0.256844490883479 |
| P61513 | P61513 | RL37A_HUMAN | Large ribosomal subunit protein eL43 (60S ribosomal protein L37a) | RPL37A | cytoplasmic translation [GO:0002181]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleus [GO:0005634] | metal ion binding [GO:0046872]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 98864.17250940115 | 0.549474156659099 | 0.084823129218878 | 0.25714705733235 |
| O96000 | O96000 | NDUBA_HUMAN | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (Complex I-PDSW) (CI-PDSW) (NADH-ubiquinone oxidoreductase PDSW subunit) | NDUFB10 | aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776] | mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747] | NADH dehydrogenase (ubiquinone) activity [GO:0008137] | 74041.1865817713 | 0.283497062676059 | 0.0849291910936984 | 0.257193370784017 |
| Q13526 | Q13526 | PIN1_HUMAN | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1) | PIN1 | cell cycle [GO:0007049]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of cell motility [GO:2000146]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of protein binding [GO:0032091]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neuron differentiation [GO:0030182]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein binding [GO:0032092]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein peptidyl-prolyl isomerization [GO:0000413]; protein stabilization [GO:0050821]; regulation of cytokinesis [GO:0032465]; regulation of gene expression [GO:0010468]; regulation of mitotic nuclear division [GO:0007088]; regulation of protein localization to nucleus [GO:1900180]; regulation of protein phosphorylation [GO:0001932]; regulation of protein stability [GO:0031647]; response to hypoxia [GO:0001666]; synapse organization [GO:0050808] | ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; midbody [GO:0030496]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524] | beta-catenin binding [GO:0008013]; cis-trans isomerase activity [GO:0016859]; cytoskeletal motor activity [GO:0003774]; GTPase activating protein binding [GO:0032794]; mitogen-activated protein kinase kinase binding [GO:0031434]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; phosphoprotein binding [GO:0051219]; phosphoserine residue binding [GO:0050815]; phosphothreonine residue binding [GO:0050816]; tau protein binding [GO:0048156]; ubiquitin ligase activator activity [GO:1990757] | 35658.2346487158 | 0.404686758181679 | 0.085214535443038 | 0.257919635587742 |
| Q09161 | Q09161 | NCBP1_HUMAN | Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit) | NCBP1 | 7-methylguanosine mRNA capping [GO:0006370]; alternative mRNA splicing, via spliceosome [GO:0000380]; cap-dependent translational initiation [GO:0002191]; defense response to virus [GO:0051607]; histone mRNA metabolic process [GO:0008334]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; mRNA metabolic process [GO:0016071]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transcription by RNA polymerase II [GO:0042789]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of cell growth [GO:0030307]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of RNA binding [GO:1905216]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; primary miRNA processing [GO:0031053]; regulation of mRNA processing [GO:0050684]; regulation of translational initiation [GO:0006446]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; RNA catabolic process [GO:0006401]; RNA splicing [GO:0008380]; snRNA export from nucleus [GO:0006408]; spliceosomal complex assembly [GO:0000245] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear cap binding complex [GO:0005846]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; RNA cap binding complex [GO:0034518] | molecular adaptor activity [GO:0060090]; mRNA binding [GO:0003729]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339] | 6151.833514510745 | -0.282379713955807 | 0.0852734963073023 | 0.25796029368776 |
| Q8WZ82 | Q8WZ82 | OVCA2_HUMAN | Esterase OVCA2 (EC 3.1.2.-) (Ovarian cancer-associated gene 2 protein) | OVCA2 | response to retinoic acid [GO:0032526]; secondary metabolic process [GO:0019748] | cytoplasm [GO:0005737]; nucleus [GO:0005634] | hydrolase activity [GO:0016787] | 12282.64721371405 | -0.411545466332164 | 0.0853952074424582 | 0.258190632534135 |
| Q9UBW8 | Q9UBW8 | CSN7A_HUMAN | COP9 signalosome complex subunit 7a (SGN7a) (Signalosome subunit 7a) (Dermal papilla-derived protein 10) (JAB1-containing signalosome subunit 7a) | COPS7A | COP9 signalosome assembly [GO:0010387]; protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; regulation of protein neddylation [GO:2000434] | COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | 24738.14144949125 | 0.22263937580318 | 0.0854981953993042 | 0.258364146737311 | |
| Q9HCU5 | Q9HCU5 | SEC12_HUMAN | Guanine nucleotide-exchange factor SEC12 (Prolactin regulatory element-binding protein) | PREB | COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein secretion [GO:0009306]; regulation of COPII vesicle coating [GO:0003400] | endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleus [GO:0005634] | DNA binding [GO:0003677]; GTPase activator activity [GO:0005096]; GTPase binding [GO:0051020]; guanyl-nucleotide exchange factor activity [GO:0005085] | 10245.9906281272 | -0.111962831530603 | 0.0857777729770802 | 0.259070821795382 |
| Q8IXM2 | Q8IXM2 | BAP18_HUMAN | Chromatin complexes subunit BAP18 (BPTF-associated protein of 18 kDa) | BAP18 | chromatin organization [GO:0006325] | cytosol [GO:0005829]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; NURF complex [GO:0016589] | DNA binding [GO:0003677]; identical protein binding [GO:0042802] | 17694.3920726019 | -0.273102317576956 | 0.0861130308085364 | 0.259783970269852 |
| O60341 | O60341 | KDM1A_HUMAN | Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A) | KDM1A | cellular response to cAMP [GO:0071320]; cellular response to gamma radiation [GO:0071480]; cellular response to UV [GO:0034644]; cerebral cortex development [GO:0021987]; DNA repair-dependent chromatin remodeling [GO:0140861]; guanine metabolic process [GO:0046098]; muscle cell development [GO:0055001]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of protein binding [GO:0032091]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron maturation [GO:0042551]; positive regulation of cell size [GO:0045793]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein demethylation [GO:0006482]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of DNA methylation-dependent heterochromatin formation [GO:0090308]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of protein localization [GO:0032880]; regulation of transcription by RNA polymerase II [GO:0006357]; response to fungicide [GO:0060992] | chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; DNA repair complex [GO:1990391]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription regulator complex [GO:0005667] | chromatin binding [GO:0003682]; demethylase activity [GO:0032451]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; FAD-dependent H3K4me/H3K4me3 demethylase activity [GO:0140682]; flavin adenine dinucleotide binding [GO:0050660]; histone demethylase activity [GO:0032452]; histone H3K4 demethylase activity [GO:0032453]; histone H3K9 demethylase activity [GO:0032454]; identical protein binding [GO:0042802]; MRF binding [GO:0043426]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor coactivator activity [GO:0030374]; oxidoreductase activity [GO:0016491]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; telomeric repeat-containing RNA binding [GO:0061752]; transcription coactivator activity [GO:0003713] | 4982.157523683805 | -0.297853011349242 | 0.0860955313164286 | 0.259783970269852 |
| Q15645 | Q15645 | PCH2_HUMAN | Pachytene checkpoint protein 2 homolog (Human papillomavirus type 16 E1 protein-binding protein) (16E1-BP) (HPV16 E1 protein-binding protein) (Thyroid hormone receptor interactor 13) (Thyroid receptor-interacting protein 13) (TR-interacting protein 13) (TRIP-13) | TRIP13 | double-strand break repair [GO:0006302]; female meiosis I [GO:0007144]; male meiosis I [GO:0007141]; meiotic recombination checkpoint signaling [GO:0051598]; mitotic spindle assembly checkpoint signaling [GO:0007094]; oocyte maturation [GO:0001556]; oogenesis [GO:0048477]; reciprocal meiotic recombination [GO:0007131]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]; transcription by RNA polymerase II [GO:0006366] | chromosome [GO:0005694]; male germ cell nucleus [GO:0001673]; nucleus [GO:0005634] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; transcription coregulator activity [GO:0003712] | 4641.05977522331 | -0.272471900800775 | 0.0861514437234472 | 0.259783970269852 |
| Q6ZSR9 | Q6ZSR9 | YJ005_HUMAN | Uncharacterized protein FLJ45252 | YJ005_HUMAN | 30169.14627699315 | -0.152354982341084 | 0.0863680472566219 | 0.260194973769763 | |||
| O14579 | O14579 | COPE_HUMAN | Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP) | COPE | endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein localization to axon [GO:0099612]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890] | COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; transport vesicle [GO:0030133] | structural molecule activity [GO:0005198] | 43210.864718769706 | 0.157918123923502 | 0.0863795880093407 | 0.260194973769763 |
| Q7LG56 | Q7LG56 | RIR2B_HUMAN | Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2) | RRM2B | 2'-deoxyribonucleotide biosynthetic process [GO:0009265]; deoxyribonucleoside triphosphate metabolic process [GO:0009200]; deoxyribonucleotide biosynthetic process [GO:0009263]; DNA repair [GO:0006281]; DNA synthesis involved in DNA repair [GO:0000731]; kidney development [GO:0001822]; mitochondrial DNA replication [GO:0006264]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; positive regulation of G0 to G1 transition [GO:0070318]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; renal system process [GO:0003014]; response to amine [GO:0014075]; response to oxidative stress [GO:0006979]; ribonucleoside diphosphate metabolic process [GO:0009185] | cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ribonucleoside-diphosphate reductase complex [GO:0005971] | identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748] | 16826.4743928862 | 0.202682936444625 | 0.0864348930309662 | 0.260223222058159 |
| P62995 | P62995 | TRA2B_HUMAN | Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B) | TRA2B | cellular response to glucose stimulus [GO:0071333]; cerebral cortex regionalization [GO:0021796]; embryonic brain development [GO:1990403]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; RNA splicing, via transesterification reactions [GO:0000375] | nuclear inner membrane [GO:0005637]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spliceosomal complex [GO:0005681] | identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; pre-mRNA binding [GO:0036002]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723] | 29714.5942036489 | 0.33762274075269 | 0.0868029864205658 | 0.261186120227052 |
| Q9C0E2 | Q9C0E2 | XPO4_HUMAN | Exportin-4 (Exp4) | XPO4 | positive regulation of protein export from nucleus [GO:0046827]; protein export from nucleus [GO:0006611] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267] | 7722.993858734066 | -0.330311571798773 | 0.0868469203155251 | 0.261186120227052 |
| E9PRG8 | E9PRG8 | CK098_HUMAN | Uncharacterized protein C11orf98 | C11orf98 | 26320.6734410657 | 0.300923321842377 | 0.0869736075862666 | 0.261428361052407 | |||
| Q13242 | Q13242 | SRSF9_HUMAN | Serine/arginine-rich splicing factor 9 (Pre-mRNA-splicing factor SRp30C) (Splicing factor, arginine/serine-rich 9) | SRSF9 | alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA processing [GO:0006397]; mRNA splice site recognition [GO:0006376]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; response to alkaloid [GO:0043279]; response to toxic substance [GO:0009636] | cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] | mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723] | 31789.757765673203 | 0.258146417952191 | 0.0872103844106305 | 0.2620010806313 |
| Q7Z3E5 | Q7Z3E5 | ARMC9_HUMAN | LisH domain-containing protein ARMC9 (Armadillo repeat-containing protein 9) (Melanoma/melanocyte-specific tumor antigen KU-MEL-1) (NS21) | ARMC9 | cilium assembly [GO:0060271]; positive regulation of smoothened signaling pathway [GO:0045880] | centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062] | 7847.854378926266 | -0.366058068294178 | 0.0876401722414796 | 0.263152737636578 | |
| P82650 | P82650 | RT22_HUMAN | Small ribosomal subunit protein mS22 (28S ribosomal protein S22, mitochondrial) (MRP-S22) (S22mt) | MRPS22 | mitochondrial translation [GO:0032543] | mitochondrial inner membrane [GO:0005743]; mitochondrial ribosome [GO:0005761]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] | structural constituent of ribosome [GO:0003735] | 13151.076683060699 | 0.198405852638961 | 0.0877910300948273 | 0.26346608925704 |
| Q9UK32 | Q9UK32 | KS6A6_HUMAN | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | RPS6KA6 | central nervous system development [GO:0007417]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; negative regulation of embryonic development [GO:0045992]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of mesoderm development [GO:2000381]; phosphorylation [GO:0016310]; signal transduction [GO:0007165] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] | ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; ribosomal protein S6 kinase activity [GO:0004711] | 34663.82272468665 | 0.677718395191527 | 0.0879104004475255 | 0.263684663279873 |
| O75874 | O75874 | IDHC_HUMAN | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (IDH1) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDPc) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) | IDH1 | 2-oxoglutarate metabolic process [GO:0006103]; female gonad development [GO:0008585]; glutathione metabolic process [GO:0006749]; glyoxylate cycle [GO:0006097]; isocitrate metabolic process [GO:0006102]; NADP metabolic process [GO:0006739]; regulation of phospholipid biosynthetic process [GO:0071071]; regulation of phospholipid catabolic process [GO:0060696]; response to oxidative stress [GO:0006979]; response to steroid hormone [GO:0048545]; tricarboxylic acid cycle [GO:0006099] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; secretory granule lumen [GO:0034774]; tertiary granule lumen [GO:1904724] | cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; isocitrate dehydrogenase (NADP+) activity [GO:0004450]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; protein homodimerization activity [GO:0042803] | 189806.2801156295 | 0.101533945049355 | 0.0884621589951088 | 0.264934690466789 |
| Q9H583 | Q9H583 | HEAT1_HUMAN | HEAT repeat-containing protein 1 (Protein BAP28) (U3 small nucleolar RNA-associated protein 10 homolog) [Cleaved into: HEAT repeat-containing protein 1, N-terminally processed] | HEATR1 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; ribosomal small subunit biogenesis [GO:0042274] | 90S preribosome [GO:0030686]; fibrillar center [GO:0001650]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; t-UTP complex [GO:0034455] | RNA binding [GO:0003723]; snoRNA binding [GO:0030515] | 3256.364318988215 | -0.368310147975868 | 0.0885987633239501 | 0.265047831569958 |
| Q9Y3D9 | Q9Y3D9 | RT23_HUMAN | Small ribosomal subunit protein mS23 (28S ribosomal protein S23, mitochondrial) (MRP-S23) (S23mt) | MRPS23 | mitochondrial translation [GO:0032543] | mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 16150.8620391765 | 0.240246020962678 | 0.0885942865842122 | 0.265047831569958 |
| P78560 | P78560 | CRADD_HUMAN | Death domain-containing protein CRADD (Caspase and RIP adapter with death domain) (RIP-associated protein with a death domain) | CRADD | apoptotic signaling pathway [GO:0097190]; cellular response to mechanical stimulus [GO:0071260]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endopeptidase complex [GO:1905369]; nucleolus [GO:0005730]; nucleus [GO:0005634] | death domain binding [GO:0070513]; protease binding [GO:0002020]; protein-macromolecule adaptor activity [GO:0030674] | 5314.142229751655 | -0.266686047307919 | 0.088717377483628 | 0.265262617848146 |
| P21291 | P21291 | CSRP1_HUMAN | Cysteine and glycine-rich protein 1 (Cysteine-rich protein 1) (CRP) (CRP1) (Epididymis luminal protein 141) (HEL-141) | CSRP1 | muscle tissue development [GO:0060537]; platelet aggregation [GO:0070527]; sarcomere organization [GO:0045214] | cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; Z disc [GO:0030018] | actinin binding [GO:0042805]; RNA binding [GO:0003723]; structural constituent of muscle [GO:0008307]; zinc ion binding [GO:0008270] | 126667.77440375401 | -0.37560373634031 | 0.0893189702081733 | 0.266779802424623 |
| Q8N3F8 | Q8N3F8 | MILK1_HUMAN | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | MICALL1 | actin cytoskeleton organization [GO:0030036]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; neuron projection development [GO:0031175]; plasma membrane tubulation [GO:0097320]; protein localization to endosome [GO:0036010]; protein targeting to membrane [GO:0006612]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; slow endocytic recycling [GO:0032458] | cytoplasmic side of endosome membrane [GO:0010009]; filamentous actin [GO:0031941]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; microtubule organizing center [GO:0005815]; recycling endosome membrane [GO:0055038] | cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; phosphatidic acid binding [GO:0070300]; small GTPase binding [GO:0031267] | 8075.860849563074 | 0.334745837001324 | 0.0896633543392527 | 0.267667315956905 |
| Q96F86 | Q96F86 | EDC3_HUMAN | Enhancer of mRNA-decapping protein 3 (LSM16 homolog) (YjeF N-terminal domain-containing protein 2) (YjeF_N2) (hYjeF_N2) (YjeF domain-containing protein 1) | EDC3 | deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087]; P-body assembly [GO:0033962] | cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; membrane [GO:0016020]; P-body [GO:0000932] | identical protein binding [GO:0042802]; mRNA binding [GO:0003729] | 5406.611916039285 | 0.26689736270215 | 0.0899878102004018 | 0.268353122418672 |
| Q8NBJ4 | Q8NBJ4 | GOLM1_HUMAN | Golgi membrane protein 1 (Golgi membrane protein GP73) (Golgi phosphoprotein 2) | GOLM1 | nucleus organization [GO:0006997]; regulation of lipid metabolic process [GO:0019216] | endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] | 14795.501622935051 | 0.3616058343072 | 0.0903983578101873 | 0.269435610390595 | |
| O43252 | O43252 | PAPS1_HUMAN | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPS synthase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK 1) (SK1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)] | PAPSS1 | 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process [GO:0050428]; phosphorylation [GO:0016310]; skeletal system development [GO:0001501]; sulfate assimilation [GO:0000103] | cytosol [GO:0005829] | adenylylsulfate kinase activity [GO:0004020]; ATP binding [GO:0005524]; nucleotidyltransferase activity [GO:0016779]; protein homodimerization activity [GO:0042803]; sulfate adenylyltransferase (ATP) activity [GO:0004781] | 28541.4769795754 | 0.0757983127984652 | 0.0905126660327662 | 0.269492782838494 |
| A6NIH7 | A6NIH7 | U119B_HUMAN | Protein unc-119 homolog B | UNC119B | cilium assembly [GO:0060271]; lipoprotein transport [GO:0042953]; nervous system development [GO:0007399] | ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytosol [GO:0005829] | lipid binding [GO:0008289] | 17180.65255439505 | 0.2748303891396 | 0.0905912518857407 | 0.269585101462504 |
| P01008 | P01008 | ANT3_HUMAN | Antithrombin-III (ATIII) (Serpin C1) | SERPINC1 | blood coagulation [GO:0007596]; regulation of blood coagulation [GO:0030193] | blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] | heparin binding [GO:0008201]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867] | 30345.7058020634 | -0.262685669934322 | 0.0907088733894619 | 0.269793426049707 |
| Q9H814 | Q9H814 | PHAX_HUMAN | Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) | PHAX | protein transport [GO:0015031]; RNA stabilization [GO:0043489]; snRNA export from nucleus [GO:0006408] | Cajal body [GO:0015030]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] | mRNA cap binding complex binding [GO:0140262]; RNA binding [GO:0003723]; toxic substance binding [GO:0015643] | 6163.034130511271 | 0.485459564793654 | 0.0908969772668879 | 0.270211056240392 |
| Q10588 | Q10588 | BST1_HUMAN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (EC 3.2.2.6) (ADP-ribosyl cyclase 2) (Bone marrow stromal cell antigen 1) (BST-1) (Cyclic ADP-ribose hydrolase 2) (cADPR hydrolase 2) (CD antigen CD157) | BST1 | humoral immune response [GO:0006959]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell population proliferation [GO:0008284]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of calcium-mediated signaling [GO:0050848]; regulation of cell-matrix adhesion [GO:0001952]; regulation of cellular extravasation [GO:0002691]; regulation of inflammatory response [GO:0050727]; regulation of integrin-mediated signaling pathway [GO:2001044]; regulation of neutrophil chemotaxis [GO:0090022]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of superoxide metabolic process [GO:0090322]; signal transduction [GO:0007165] | extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; specific granule membrane [GO:0035579]; uropod [GO:0001931] | NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; phosphorus-oxygen lyase activity [GO:0016849]; transferase activity [GO:0016740] | 38623.9961725799 | 0.345135871369581 | 0.0909773721548544 | 0.27030822791264 |
| P61020 | P61020 | RAB5B_HUMAN | Ras-related protein Rab-5B (EC 3.6.5.2) | RAB5B | antigen processing and presentation [GO:0019882]; endocytosis [GO:0006897]; endosome organization [GO:0007032]; intracellular protein transport [GO:0006886]; plasma membrane to endosome transport [GO:0048227]; regulation of endocytosis [GO:0030100] | early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endomembrane system [GO:0012505]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672] | G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924] | 45818.6689563459 | -0.211706474660378 | 0.0911161695932003 | 0.270578730039346 |
| P46108 | P46108 | CRK_HUMAN | Adapter molecule crk (Proto-oncogene c-Crk) (p38) | CRK | actin cytoskeleton organization [GO:0030036]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; cellular response to endothelin [GO:1990859]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to nitric oxide [GO:0071732]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cerebellar neuron development [GO:0098749]; cerebral cortex development [GO:0021987]; dendrite development [GO:0016358]; ephrin receptor signaling pathway [GO:0048013]; establishment of cell polarity [GO:0030010]; helper T cell diapedesis [GO:0035685]; hippocampus development [GO:0021766]; lipid metabolic process [GO:0006629]; negative regulation of cell motility [GO:2000146]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of wound healing [GO:0061045]; neuron migration [GO:0001764]; positive regulation of cell growth [GO:0030307]; positive regulation of JNK cascade [GO:0046330]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; postsynaptic specialization assembly [GO:0098698]; protein localization to membrane [GO:0072657]; reelin-mediated signaling pathway [GO:0038026]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of cell shape [GO:0008360]; regulation of dendrite development [GO:0050773]; regulation of GTPase activity [GO:0043087]; regulation of intracellular signal transduction [GO:1902531]; regulation of protein binding [GO:0043393]; regulation of signal transduction [GO:0009966]; regulation of T cell migration [GO:2000404]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cholecystokinin [GO:0061847]; response to hepatocyte growth factor [GO:0035728]; response to hydrogen peroxide [GO:0042542]; response to yeast [GO:0001878]; signal transduction [GO:0007165] | actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] | cytoskeletal protein binding [GO:0008092]; ephrin receptor binding [GO:0046875]; insulin-like growth factor receptor binding [GO:0005159]; kinase binding [GO:0019900]; phosphotyrosine residue binding [GO:0001784]; protein phosphorylated amino acid binding [GO:0045309]; protein self-association [GO:0043621]; protein tyrosine kinase binding [GO:1990782]; receptor tyrosine kinase binding [GO:0030971]; scaffold protein binding [GO:0097110]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591]; signaling receptor complex adaptor activity [GO:0030159]; ubiquitin protein ligase binding [GO:0031625] | 48262.50936480965 | 0.289942068151888 | 0.0918902557421141 | 0.272449078511156 |
| P18621 | P18621 | RL17_HUMAN | Large ribosomal subunit protein uL22 (60S ribosomal protein L17) (60S ribosomal protein L23) (PD-1) | RPL17 | cytoplasmic translation [GO:0002181]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; nucleus [GO:0005634] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 271202.0035985375 | 0.211874254661577 | 0.0918626858507731 | 0.272449078511156 |
| P80723 | P80723 | BASP1_HUMAN | Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) | BASP1 | diaphragm development [GO:0060539]; gonad development [GO:0008406]; mesenchymal to epithelial transition [GO:0060231]; metanephric mesenchyme development [GO:0072075]; negative regulation of DNA-templated transcription [GO:0045892]; podocyte differentiation [GO:0072112]; positive regulation of heart growth [GO:0060421]; positive regulation of metanephric ureteric bud development [GO:2001076]; protein homooligomerization [GO:0051260]; substantia nigra development [GO:0021762]; supramolecular fiber organization [GO:0097435]; thorax and anterior abdomen determination [GO:0007356] | cell junction [GO:0030054]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; growth cone [GO:0030426]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; vesicle [GO:0031982] | calmodulin binding [GO:0005516]; protein domain specific binding [GO:0019904]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714] | 280173.1989577735 | 0.431332160228079 | 0.0919400404396617 | 0.27244943424135 |
| Q53QV2 | Q53QV2 | LBH_HUMAN | Protein LBH (hLBH) (Limb bud and heart development protein homolog) | LBH | mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of stem cell differentiation [GO:2000737]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mammary stem cell proliferation [GO:2000103]; positive regulation of somatic stem cell division [GO:1904677]; positive regulation of somatic stem cell population maintenance [GO:1904674]; regulation of MAPK cascade [GO:0043408] | cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] | 11623.09036133705 | -0.743067507590175 | 0.0920346306279463 | 0.27244943424135 | |
| Q6IQ49 | Q6IQ49 | SDE2_HUMAN | Splicing regulator SDE2 (Replication stress response regulator SDE2) | SDE2 | cell division [GO:0051301]; cellular response to UV [GO:0034644]; DNA replication [GO:0006260]; endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000479]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; mRNA cis splicing, via spliceosome [GO:0045292]; protein processing [GO:0016485]; protein ubiquitination [GO:0016567] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | damaged DNA binding [GO:0003684]; snoRNA binding [GO:0030515] | 4131.23120009807 | 0.233429941002699 | 0.0920122514085733 | 0.27244943424135 |
| Q14161 | Q14161 | GIT2_HUMAN | ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) | GIT2 | brain development [GO:0007420]; regulation of ARF protein signal transduction [GO:0032012]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; synaptic vesicle recycling [GO:0036465] | focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; presynapse [GO:0098793]; synapse [GO:0045202] | GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267] | 10087.467174206595 | 0.289219723356557 | 0.0921964363508161 | 0.27278590515077 |
| Q53H12 | Q53H12 | AGK_HUMAN | Acylglycerol kinase, mitochondrial (hAGK) (EC 2.7.1.107) (EC 2.7.1.138) (EC 2.7.1.94) (Multiple substrate lipid kinase) (HsMuLK) (MuLK) (Multi-substrate lipid kinase) | AGK | ceramide biosynthetic process [GO:0046513]; glycerolipid metabolic process [GO:0046486]; lipid phosphorylation [GO:0046834]; protein insertion into mitochondrial inner membrane [GO:0045039]; sphingosine biosynthetic process [GO:0046512] | cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721] | acylglycerol kinase activity [GO:0047620]; ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; ceramide kinase activity [GO:0001729]; D-erythro-sphingosine kinase activity [GO:0017050]; dihydroceramide kinase activity [GO:0102773] | 13010.74150387415 | 0.18171876009341 | 0.0927147567638182 | 0.274033287336356 |
| Q9NVH1 | Q9NVH1 | DJC11_HUMAN | DnaJ homolog subfamily C member 11 | DNAJC11 | cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007] | MIB complex [GO:0140275]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; SAM complex [GO:0001401] | 14400.75493298955 | -0.137881468541544 | 0.092902956591626 | 0.274446377501644 | |
| P09455 | P09455 | RET1_HUMAN | Retinol-binding protein 1 (Cellular retinol-binding protein) (CRBP) (Cellular retinol-binding protein I) (CRBP-I) | RBP1 | fatty acid transport [GO:0015908]; lipid homeostasis [GO:0055088]; retinoic acid biosynthetic process [GO:0002138]; vitamin A metabolic process [GO:0006776] | cytosol [GO:0005829]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | all-trans-retinol binding [GO:1904768]; fatty acid binding [GO:0005504]; retinal binding [GO:0016918]; retinoid binding [GO:0005501] | 15372.39279023965 | -0.407817877538081 | 0.0930762645209352 | 0.27481506762669 |
| Q8WTV0 | Q8WTV0 | SCRB1_HUMAN | Scavenger receptor class B member 1 (SRB1) (CD36 and LIMPII analogous 1) (CLA-1) (CD36 antigen-like 1) (Collagen type I receptor, thrombospondin receptor-like 1) (SR-BI) (CD antigen CD36) | SCARB1 | adhesion of symbiont to host [GO:0044406]; blood vessel endothelial cell migration [GO:0043534]; carotenoid transport [GO:0046867]; cholesterol catabolic process [GO:0006707]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; detection of lipopolysaccharide [GO:0032497]; endothelial cell proliferation [GO:0001935]; high-density lipoprotein particle clearance [GO:0034384]; high-density lipoprotein particle remodeling [GO:0034375]; intestinal lipid absorption [GO:0098856]; lipopolysaccharide transport [GO:0015920]; low-density lipoprotein particle clearance [GO:0034383]; phospholipid transport [GO:0015914]; plasma lipoprotein particle clearance [GO:0034381]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of triglyceride biosynthetic process [GO:0010867]; recognition of apoptotic cell [GO:0043654]; regulation of phagocytosis [GO:0050764]; regulation of phosphatidylcholine catabolic process [GO:0010899]; reverse cholesterol transport [GO:0043691]; triglyceride homeostasis [GO:0070328]; vitamin transmembrane transport [GO:0035461]; wound healing [GO:0042060] | caveola [GO:0005901]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endocytic vesicle membrane [GO:0030666]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886] | 1-phosphatidylinositol binding [GO:0005545]; amyloid-beta binding [GO:0001540]; apolipoprotein A-I binding [GO:0034186]; apolipoprotein binding [GO:0034185]; high-density lipoprotein particle binding [GO:0008035]; high-density lipoprotein particle receptor activity [GO:0070506]; lipid binding [GO:0008289]; lipopolysaccharide binding [GO:0001530]; lipopolysaccharide immune receptor activity [GO:0001875]; low-density lipoprotein particle binding [GO:0030169]; phosphatidylserine binding [GO:0001786]; scavenger receptor activity [GO:0005044]; virus receptor activity [GO:0001618] | 13129.504505413199 | 0.452427208485873 | 0.0932176855505789 | 0.27508927412999 |
| P48507 | P48507 | GSH0_HUMAN | Glutamate--cysteine ligase regulatory subunit (GCS light chain) (Gamma-ECS regulatory subunit) (Gamma-glutamylcysteine synthetase regulatory subunit) (Glutamate--cysteine ligase modifier subunit) | GCLM | apoptotic mitochondrial changes [GO:0008637]; blood vessel diameter maintenance [GO:0097746]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to glucose stimulus [GO:0071333]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to thyroxine stimulus [GO:0097069]; cysteine metabolic process [GO:0006534]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; hepatic stellate cell activation [GO:0035733]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of neuron apoptotic process [GO:0043524]; regulation of mitochondrial depolarization [GO:0051900]; response to activity [GO:0014823]; response to human chorionic gonadotropin [GO:0044752]; response to nitrosative stress [GO:0051409]; response to nutrient [GO:0007584]; response to oxidative stress [GO:0006979]; response to xenobiotic stimulus [GO:0009410] | cytosol [GO:0005829]; glutamate-cysteine ligase complex [GO:0017109] | enzyme regulator activity [GO:0030234]; glutamate-cysteine ligase activity [GO:0004357]; glutamate-cysteine ligase catalytic subunit binding [GO:0035226]; protein-containing complex binding [GO:0044877] | 55746.1131841773 | 0.244163823408996 | 0.093745592638266 | 0.276071999942004 |
| P46783 | P46783 | RS10_HUMAN | Small ribosomal subunit protein eS10 (40S ribosomal protein S10) | RPS10 | cytoplasmic translation [GO:0002181]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribosome [GO:0005840] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 524475.6469068311 | 0.340623278909028 | 0.0936525925776174 | 0.276071999942004 |
| Q6UXV4 | Q6UXV4 | MIC27_HUMAN | MICOS complex subunit MIC27 (Apolipoprotein O-like) (Protein FAM121A) | APOOL | cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007] | extracellular region [GO:0005576]; MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; platelet alpha granule lumen [GO:0031093]; SAM complex [GO:0001401] | 24124.310353246 | 0.213826306229011 | 0.0938010677164616 | 0.276091869964401 | |
| Q9GZT3 | Q9GZT3 | SLIRP_HUMAN | SRA stem-loop-interacting RNA-binding protein, mitochondrial | SLIRP | flagellated sperm motility [GO:0030317]; mitochondrion organization [GO:0007005]; negative regulation of mitochondrial RNA catabolic process [GO:0000961]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; single fertilization [GO:0007338]; spermatid development [GO:0007286] | acrosomal vesicle [GO:0001669]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:1990904]; sperm flagellum [GO:0036126] | mRNA 3'-UTR binding [GO:0003730]; poly(G) binding [GO:0034046]; RNA binding [GO:0003723] | 27980.20685635235 | 0.349622581489969 | 0.0944490964183122 | 0.277710731866195 |
| P09661 | P09661 | RU2A_HUMAN | U2 small nuclear ribonucleoprotein A' (U2 snRNP A') | SNRPA1 | mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; spermatogenesis [GO:0007283]; U2-type prespliceosome assembly [GO:1903241] | catalytic step 2 spliceosome [GO:0071013]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small nuclear ribonucleoprotein complex [GO:0030532]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684] | RNA binding [GO:0003723]; U2 snRNA binding [GO:0030620] | 78209.47491655975 | 0.290193789917838 | 0.0944281607752172 | 0.277710731866195 |
| P62937 | P62937 | PPIA_HUMAN | Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed] | PPIA | activation of protein kinase B activity [GO:0032148]; apoptotic process [GO:0006915]; cell adhesion molecule production [GO:0060352]; cellular response to oxidative stress [GO:0034599]; endothelial cell activation [GO:0042118]; leukocyte chemotaxis [GO:0030595]; lipid droplet organization [GO:0034389]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of protein K48-linked ubiquitination [GO:0061944]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of viral life cycle [GO:1903901]; neuron differentiation [GO:0030182]; neutrophil chemotaxis [GO:0030593]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein secretion [GO:0050714]; positive regulation of viral genome replication [GO:0045070]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; regulation of apoptotic signaling pathway [GO:2001233]; regulation of viral genome replication [GO:0045069]; response to hypoxia [GO:0001666]; viral release from host cell [GO:0019076] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774]; vesicle [GO:0031982] | cyclosporin A binding [GO:0016018]; heparan sulfate binding [GO:1904399]; integrin binding [GO:0005178]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082]; virion binding [GO:0046790] | 684213.379425521 | 0.273518570895758 | 0.0946022787815735 | 0.278016862850828 |
| P62906 | P62906 | RL10A_HUMAN | Large ribosomal subunit protein uL1 (60S ribosomal protein L10a) (CSA-19) (Neural precursor cell expressed developmentally down-regulated protein 6) (NEDD-6) | RPL10A | cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA [GO:0000470]; response to ethanol [GO:0045471]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 142694.9365256205 | 0.277999769956897 | 0.0949892270474048 | 0.278864746347459 |
| Q99436 | Q99436 | PSB7_HUMAN | Proteasome subunit beta type-7 (EC 3.4.25.1) (Macropain chain Z) (Multicatalytic endopeptidase complex chain Z) (Proteasome subunit Z) | PSMB7 | proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]; secretory granule lumen [GO:0034774] | endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298] | 39059.89722620805 | 0.24571893422947 | 0.0955983175280335 | 0.280507543818663 |
| O00560 | O00560 | SDCB1_HUMAN | Syntenin-1 (Melanoma differentiation-associated protein 9) (MDA-9) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18) (Scaffold protein Pbp1) (Syndecan-binding protein 1) | SDCBP | actin cytoskeleton organization [GO:0030036]; chemical synaptic transmission [GO:0007268]; intracellular signal transduction [GO:0035556]; negative regulation of receptor internalization [GO:0002091]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; positive regulation of JNK cascade [GO:0046330]; positive regulation of phosphorylation [GO:0042327]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; presynapse assembly [GO:0099054]; protein targeting to membrane [GO:0006612]; Ras protein signal transduction [GO:0007265]; regulation of mitotic cell cycle [GO:0007346]; substrate-dependent cell migration, cell extension [GO:0006930] | adherens junction [GO:0005912]; azurophil granule lumen [GO:0035578]; blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; focal adhesion [GO:0005925]; interleukin-5 receptor complex [GO:0005895]; melanosome [GO:0042470]; membrane [GO:0016020]; membrane raft [GO:0045121]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynapse [GO:0098793] | cell adhesion molecule binding [GO:0050839]; cytoskeletal anchor activity [GO:0008093]; ephrin receptor binding [GO:0046875]; frizzled binding [GO:0005109]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; interleukin-5 receptor binding [GO:0005137]; ionotropic glutamate receptor binding [GO:0035255]; neurexin family protein binding [GO:0042043]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein heterodimerization activity [GO:0046982]; protein sequestering activity [GO:0140311]; protein-containing complex binding [GO:0044877]; syndecan binding [GO:0045545] | 46243.7853590697 | -0.126095300485224 | 0.0957496809931923 | 0.280510606252407 |
| Q9H269 | Q9H269 | VPS16_HUMAN | Vacuolar protein sorting-associated protein 16 homolog (hVPS16) | VPS16 | autophagosome maturation [GO:0097352]; endosomal transport [GO:0016197]; endosomal vesicle fusion [GO:0034058]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; regulation of SNARE complex assembly [GO:0035542]; vacuole fusion, non-autophagic [GO:0042144] | autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; recycling endosome [GO:0055037] | actin binding [GO:0003779] | 12110.498730754302 | -0.273713462764028 | 0.095708217158763 | 0.280510606252407 |
| Q86YM7 | Q86YM7 | HOME1_HUMAN | Homer protein homolog 1 (Homer-1) | HOMER1 | behavioral response to cocaine [GO:0048148]; chemical synaptic transmission [GO:0007268]; circadian rhythm [GO:0007623]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; phospholipase C-activating G protein-coupled glutamate receptor signaling pathway [GO:0007206]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of signal transduction [GO:0009967]; protein localization to synapse [GO:0035418]; protein tetramerization [GO:0051262]; regulation of calcium ion import [GO:0090279]; regulation of cation channel activity [GO:2001257]; regulation of dendritic spine maintenance [GO:1902950]; regulation of store-operated calcium entry [GO:2001256]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to calcium ion [GO:0051592]; response to nicotine [GO:0035094]; skeletal muscle contraction [GO:0003009]; skeletal muscle fiber development [GO:0048741] | apical part of cell [GO:0045177]; axon [GO:0030424]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; neuron spine [GO:0044309]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic cytosol [GO:0099524]; postsynaptic density [GO:0014069]; Z disc [GO:0030018] | G protein-coupled glutamate receptor binding [GO:0035256]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; signaling adaptor activity [GO:0035591]; structural constituent of postsynapse [GO:0099186]; transmembrane transporter binding [GO:0044325]; type 5 metabotropic glutamate receptor binding [GO:0031802] | 13026.52839986435 | 0.250933759805945 | 0.0960672751140085 | 0.280982575760443 |
| Q9BQG0 | Q9BQG0 | MBB1A_HUMAN | Myb-binding protein 1A | MYBBP1A | cellular response to glucose starvation [GO:0042149]; chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of DNA-templated transcription [GO:0045892]; osteoblast differentiation [GO:0001649]; positive regulation of anoikis [GO:2000210]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; regulation of DNA-templated transcription [GO:0006355]; regulation of G1 to G0 transition [GO:1903450]; respiratory electron transport chain [GO:0022904]; ribosome biogenesis [GO:0042254] | B-WICH complex [GO:0110016]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; NLS-dependent protein nuclear import complex [GO:0042564]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | E-box binding [GO:0070888]; rDNA binding [GO:0000182]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; transcription corepressor activity [GO:0003714] | 8702.681484468885 | -0.275033837002962 | 0.0961073476568547 | 0.280982575760443 |
| P61586 | P61586 | RHOA_HUMAN | Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12) | RHOA | actin cytoskeleton organization [GO:0030036]; alpha-beta T cell lineage commitment [GO:0002363]; androgen receptor signaling pathway [GO:0030521]; angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure [GO:0001998]; aortic valve formation [GO:0003189]; apical junction assembly [GO:0043297]; apolipoprotein A-I-mediated signaling pathway [GO:0038027]; beta selection [GO:0043366]; bone trabecula morphogenesis [GO:0061430]; cell junction assembly [GO:0034329]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-matrix adhesion [GO:0007160]; cellular response to chemokine [GO:1990869]; cellular response to cytokine stimulus [GO:0071345]; cellular response to lipopolysaccharide [GO:0071222]; cerebral cortex cell migration [GO:0021795]; cleavage furrow formation [GO:0036089]; cytoplasmic microtubule organization [GO:0031122]; endothelial cell migration [GO:0043542]; endothelial tube lumen extension [GO:0097498]; establishment of epithelial cell apical/basal polarity [GO:0045198]; forebrain radial glial cell differentiation [GO:0021861]; kidney development [GO:0001822]; mitotic cleavage furrow formation [GO:1903673]; mitotic spindle assembly [GO:0090307]; motor neuron apoptotic process [GO:0097049]; negative chemotaxis [GO:0050919]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell size [GO:0045792]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of intracellular steroid hormone receptor signaling pathway [GO:0033144]; negative regulation of motor neuron apoptotic process [GO:2000672]; negative regulation of oxidative phosphorylation [GO:0090324]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neuron migration [GO:0001764]; odontogenesis [GO:0042476]; ossification involved in bone maturation [GO:0043931]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokinesis [GO:0032467]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of lipase activity [GO:0060193]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of podosome assembly [GO:0071803]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of T cell migration [GO:2000406]; positive regulation of vascular associated smooth muscle contraction [GO:1904695]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell migration [GO:0030334]; regulation of focal adhesion assembly [GO:0051893]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of modification of postsynaptic structure [GO:0099159]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of neuron projection development [GO:0010975]; regulation of osteoblast proliferation [GO:0033688]; regulation of systemic arterial blood pressure by endothelin [GO:0003100]; regulation of transcription by RNA polymerase II [GO:0006357]; Rho protein signal transduction [GO:0007266]; Roundabout signaling pathway [GO:0035385]; semaphorin-plexin signaling pathway [GO:0071526]; skeletal muscle satellite cell migration [GO:1902766]; skeletal muscle tissue development [GO:0007519]; stress fiber assembly [GO:0043149]; substantia nigra development [GO:0021762]; substrate adhesion-dependent cell spreading [GO:0034446]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]; wound healing, spreading of cells [GO:0044319] | apical junction complex [GO:0043296]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell periphery [GO:0071944]; cleavage furrow [GO:0032154]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; midbody [GO:0030496]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; ruffle membrane [GO:0032587]; secretory granule membrane [GO:0030667]; vesicle [GO:0031982] | G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin binding [GO:0017022]; protein kinase binding [GO:0019901] | 48284.494211420606 | 0.293634792704402 | 0.0960383828483188 | 0.280982575760443 |
| P62753 | P62753 | RS6_HUMAN | Small ribosomal subunit protein eS6 (40S ribosomal protein S6) (Phosphoprotein NP33) | RPS6 | activation-induced cell death of T cells [GO:0006924]; cytoplasmic translation [GO:0002181]; erythrocyte development [GO:0048821]; G1/S transition of mitotic cell cycle [GO:0000082]; gastrulation [GO:0007369]; glucose homeostasis [GO:0042593]; mammalian oogenesis stage [GO:0022605]; negative regulation of apoptotic process [GO:0043066]; placenta development [GO:0001890]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell population proliferation [GO:0008284]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; T cell differentiation in thymus [GO:0033077]; T cell proliferation involved in immune response [GO:0002309]; TOR signaling [GO:0031929]; translation [GO:0006412] | cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:1990904]; small ribosomal subunit [GO:0015935]; small-subunit processome [GO:0032040] | protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 352545.223167016 | 0.207081561133299 | 0.0962360911980162 | 0.281213869380072 |
| Q99567 | Q99567 | NUP88_HUMAN | Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup88) | NUP88 | mRNA export from nucleus [GO:0006406]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit export from nucleus [GO:0000056] | cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654] | structural constituent of nuclear pore [GO:0017056] | 10506.9472207955 | -0.345636070538902 | 0.0964513805381786 | 0.281552561632828 |
| O75822 | O75822 | EIF3J_HUMAN | Eukaryotic translation initiation factor 3 subunit J (eIF3j) (Eukaryotic translation initiation factor 3 subunit 1) (eIF-3-alpha) (eIF3 p35) | EIF3J | formation of cytoplasmic translation initiation complex [GO:0001732]; translational initiation [GO:0006413] | cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852] | identical protein binding [GO:0042802]; translation initiation factor activity [GO:0003743] | 44799.332465772546 | 0.229844112108631 | 0.0965188188101707 | 0.28160433953575 |
| Q96FZ7 | Q96FZ7 | CHMP6_HUMAN | Charged multivesicular body protein 6 (Chromatin-modifying protein 6) (Vacuolar protein sorting-associated protein 20) (Vps20) (hVps20) | CHMP6 | autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; ESCRT III complex assembly [GO:1904902]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; regulation of mitotic spindle assembly [GO:1901673]; regulation of protein catabolic process [GO:0042176]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle budding from membrane [GO:0006900]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702] | amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886] | protein-containing complex binding [GO:0044877] | 30807.036596513302 | 0.235610334531565 | 0.0969689447416945 | 0.282626564252284 |
| P25787 | P25787 | PSA2_HUMAN | Proteasome subunit alpha type-2 (Macropain subunit C3) (Multicatalytic endopeptidase complex subunit C3) (Proteasome component C3) | PSMA2 | proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; response to virus [GO:0009615] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; secretory granule lumen [GO:0034774] | 104251.9397309195 | 0.155725214513088 | 0.0975153264143083 | 0.284006971399928 | |
| P07919 | P07919 | QCR6_HUMAN | Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein) | UQCRH | aerobic respiration [GO:0009060]; cellular respiration [GO:0045333]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; oxidative phosphorylation [GO:0006119] | mitochondrial inner membrane [GO:0005743]; mitochondrial respirasome [GO:0005746]; mitochondrial respiratory chain complex III [GO:0005750]; mitochondrion [GO:0005739] | ubiquinol-cytochrome-c reductase activity [GO:0008121] | 9662.85233714384 | 2.00983847287716 | 0.0975428108620295 | 0.284006971399928 |
| Q8IWX8 | Q8IWX8 | CHERP_HUMAN | Calcium homeostasis endoplasmic reticulum protein (ERPROT 213-21) (SR-related CTD-associated factor 6) | CHERP | intracellular calcium ion homeostasis [GO:0006874]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; release of sequestered calcium ion into cytosol [GO:0051209]; RNA processing [GO:0006396] | cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; sarcoplasmic reticulum membrane [GO:0033017] | RNA binding [GO:0003723]; transmembrane transporter binding [GO:0044325] | 8097.07631999695 | -0.220799352630522 | 0.0975962012407191 | 0.284016474694358 |
| Q01844 | Q01844 | EWS_HUMAN | RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein) | EWSR1 | regulation of DNA-templated transcription [GO:0006355] | Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712] | 102141.2760514835 | 0.179510891241583 | 0.0978424531548513 | 0.284586929966831 |
| Q9BVP2 | Q9BVP2 | GNL3_HUMAN | Guanine nucleotide-binding protein-like 3 (E2-induced gene 3 protein) (Novel nucleolar protein 47) (NNP47) (Nucleolar GTP-binding protein 3) (Nucleostemin) | GNL3 | positive regulation of miRNA transcription [GO:1902895]; positive regulation of protein localization to chromosome, telomeric region [GO:1904816]; positive regulation of protein sumoylation [GO:0033235]; positive regulation of telomere maintenance [GO:0032206]; regulation of cell population proliferation [GO:0042127]; stem cell division [GO:0017145]; stem cell population maintenance [GO:0019827] | chromosome [GO:0005694]; extracellular space [GO:0005615]; membrane [GO:0016020]; midbody [GO:0030496]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleus [GO:0005634] | GTP binding [GO:0005525]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723] | 13791.7703590063 | -0.215596110029012 | 0.0979933967170859 | 0.284879725910215 |
| O94929 | O94929 | ABLM3_HUMAN | Actin-binding LIM protein 3 (abLIM-3) (Actin-binding LIM protein family member 3) | ABLIM3 | cilium assembly [GO:0060271]; cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription by RNA polymerase II [GO:0006366] | actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; stress fiber [GO:0001725] | actin filament binding [GO:0051015]; metal ion binding [GO:0046872] | 4170.10145516577 | 0.865918414108292 | 0.0981505511753638 | 0.285190268184416 |
| Q8IYB5 | Q8IYB5 | SMAP1_HUMAN | Stromal membrane-associated protein 1 | SMAP1 | positive regulation of erythrocyte differentiation [GO:0045648]; regulation of clathrin-dependent endocytosis [GO:2000369] | cytoplasm [GO:0005737]; plasma membrane [GO:0005886] | clathrin binding [GO:0030276]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] | 21966.5876353489 | 0.253772644685833 | 0.0984887107971358 | 0.286026158573332 |
| Q8TB52 | Q8TB52 | FBX30_HUMAN | F-box only protein 30 | FBXO30 | protein ubiquitination [GO:0016567] | cytosol [GO:0005829] | ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] | 823.9225723897196 | -2.13169205527554 | 0.098604316308231 | 0.286215192726658 |
| Q9NRQ2 | Q9NRQ2 | PLS4_HUMAN | Phospholipid scramblase 4 (PL scramblase 4) (Ca(2+)-dependent phospholipid scramblase 4) (Cell growth-inhibiting gene 43 protein) (TRA1) | PLSCR4 | cellular response to lipopolysaccharide [GO:0071222]; plasma membrane phospholipid scrambling [GO:0017121] | plasma membrane [GO:0005886] | calcium ion binding [GO:0005509]; CD4 receptor binding [GO:0042609]; enzyme binding [GO:0019899]; phospholipid scramblase activity [GO:0017128]; SH3 domain binding [GO:0017124] | 7437.953172438825 | -1.34884625276258 | 0.0995869273491291 | 0.288771509907966 |
| Q5VT52 | Q5VT52 | RPRD2_HUMAN | Regulation of nuclear pre-mRNA domain-containing protein 2 | RPRD2 | mRNA 3'-end processing [GO:0031124] | nucleoplasm [GO:0005654]; transcription preinitiation complex [GO:0097550] | RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II complex binding [GO:0000993] | 2725.3544385937203 | -0.431779264057486 | 0.0999839146769629 | 0.289774353227454 |
| Q04837 | Q04837 | SSBP_HUMAN | Single-stranded DNA-binding protein, mitochondrial (Mt-SSB) (MtSSB) (PWP1-interacting protein 17) | SSBP1 | DNA unwinding involved in DNA replication [GO:0006268]; mitochondrial DNA replication [GO:0006264]; positive regulation of helicase activity [GO:0051096]; positive regulation of mitochondrial DNA replication [GO:0090297]; protein homotetramerization [GO:0051289] | extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634] | chromatin binding [GO:0003682]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697] | 45285.53411626505 | 0.326592641751648 | 0.100075208370701 | 0.289890659830467 |
| Q9Y5Y2 | Q9Y5Y2 | NUBP2_HUMAN | Cytosolic Fe-S cluster assembly factor NUBP2 (Nucleotide-binding protein 2) (NBP 2) | NUBP2 | cell projection organization [GO:0030030]; iron-sulfur cluster assembly [GO:0016226] | centriole [GO:0005814]; cilium [GO:0005929]; cytosol [GO:0005829]; nucleus [GO:0005634]; spindle pole centrosome [GO:0031616] | 4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATP-dependent FeS chaperone activity [GO:0140663]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166] | 12348.0323604298 | -0.392261822296293 | 0.10030957701191 | 0.290421085002292 |
| P30050 | P30050 | RL12_HUMAN | Large ribosomal subunit protein uL11 (60S ribosomal protein L12) | RPL12 | cytoplasmic translation [GO:0002181]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; postsynaptic density [GO:0014069] | large ribosomal subunit rRNA binding [GO:0070180]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 1137280.717830895 | 0.200525561316426 | 0.10047256178401 | 0.290744399932686 |
| Q96S19 | Q96S19 | MTL26_HUMAN | Methyltransferase-like 26 | METTL26 | 12514.119434754 | -0.377933636991869 | 0.100722715996119 | 0.2911732717661 | |||
| P61758 | P61758 | PFD3_HUMAN | Prefoldin subunit 3 (HIBBJ46) (von Hippel-Lindau-binding protein 1) (VBP-1) (VHL-binding protein 1) | VBP1 | chaperone-mediated protein folding [GO:0061077]; microtubule-based process [GO:0007017]; negative regulation of amyloid fibril formation [GO:1905907]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; prefoldin complex [GO:0016272] | amyloid-beta binding [GO:0001540]; tubulin binding [GO:0015631]; unfolded protein binding [GO:0051082] | 58027.344589004206 | 0.346806931091548 | 0.100723546181002 | 0.2911732717661 |
| Q4L180 | Q4L180 | FIL1L_HUMAN | Filamin A-interacting protein 1-like (130 kDa GPBP-interacting protein) (90 kDa GPBP-interacting protein) (Protein down-regulated in ovarian cancer 1) (DOC-1) | FILIP1L | cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] | 10541.56750277275 | -0.257942670445184 | 0.101030125150784 | 0.291316381223583 | ||
| O60318 | O60318 | GANP_HUMAN | Germinal-center associated nuclear protein (GANP) (EC 2.3.1.48) (80 kDa MCM3-associated protein) (MCM3 acetylating protein) (MCM3AP) (EC 2.3.1.-) (MCM3 acetyltransferase) | MCM3AP | mRNA export from nucleus [GO:0006406]; nucleosome organization [GO:0034728]; poly(A)+ mRNA export from nucleus [GO:0016973]; protein transport [GO:0015031]; somatic hypermutation of immunoglobulin genes [GO:0016446] | chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription export complex 2 [GO:0070390] | chromatin binding [GO:0003682]; histone acetyltransferase activity [GO:0004402]; histone binding [GO:0042393]; histone H3 acetyltransferase activity [GO:0010484]; nucleic acid binding [GO:0003676] | 5479.77863627876 | -0.513959758025821 | 0.100992209825808 | 0.291316381223583 |
| Q16795 | Q16795 | NDUA9_HUMAN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (Complex I-39kD) (CI-39kD) (NADH-ubiquinone oxidoreductase 39 kDa subunit) | NDUFA9 | aerobic respiration [GO:0009060]; circadian rhythm [GO:0007623]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; sodium ion transport [GO:0006814]; ubiquinone-6 biosynthetic process [GO:1901006] | mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; nucleus [GO:0005634] | NADH dehydrogenase (ubiquinone) activity [GO:0008137]; NADH dehydrogenase activity [GO:0003954]; protein-containing complex binding [GO:0044877] | 14541.452229653049 | 0.208021447020716 | 0.100977309201935 | 0.291316381223583 |
| O95685 | O95685 | PPR3D_HUMAN | Protein phosphatase 1 regulatory subunit 3D (Protein phosphatase 1 regulatory subunit 6) (PP1 subunit R6) (Protein phosphatase 1-binding subunit R6) | PPP1R3D | glycogen metabolic process [GO:0005977]; regulation of glycogen biosynthetic process [GO:0005979]; regulation of glycogen catabolic process [GO:0005981] | glycogen granule [GO:0042587]; protein phosphatase type 1 complex [GO:0000164] | glycogen binding [GO:2001069]; protein phosphatase 1 binding [GO:0008157]; protein serine/threonine phosphatase activity [GO:0004722] | 3267.01746731973 | 1.05194237581278 | 0.100895794952201 | 0.291316381223583 |
| Q9BV38 | Q9BV38 | WDR18_HUMAN | WD repeat-containing protein 18 | WDR18 | DNA-templated DNA replication [GO:0006261]; rRNA processing [GO:0006364] | dynein axonemal particle [GO:0120293]; nuclear pre-replicative complex [GO:0005656]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; rixosome complex [GO:0120330] | 16589.4916356082 | -0.157228984810378 | 0.101019012948673 | 0.291316381223583 |
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| Q15149 | |||||||||
| Q99715 | |||||||||
| P02452 | |||||||||
| P02751 | |||||||||
| P98160 | |||||||||
| P08123 | |||||||||
| P02461 | |||||||||
| P07996 | |||||||||
| Q8WWI1 | |||||||||
| P05997 | |||||||||
| P20908 | |||||||||
| Q8WUJ3 | |||||||||
| P21333 | |||||||||
| O75369 | |||||||||
| Q15063 | |||||||||
| P02786 | |||||||||
| Q12884 | |||||||||
| P12814 | |||||||||
| Q9UDY2 | |||||||||
| Q14195 | |||||||||
| Q02952 | |||||||||
| Q9NZM1 | |||||||||
| P35579 | |||||||||
| P35354 | |||||||||
| P47895 | |||||||||
| Q09666 | |||||||||
| P11717 | |||||||||
| Q14112 | |||||||||
| Q13620 | |||||||||
| P43490 | |||||||||
| Q3SY69 | |||||||||
| P17812 | |||||||||
| P21980 | |||||||||
| Q16647 | |||||||||
| P01024 | |||||||||
| Q5SW79 | |||||||||
| P06396 | |||||||||
| P12111 | |||||||||
| P35221 | |||||||||
| P12429 | |||||||||
| P78559 | |||||||||
| Q76M96 | |||||||||
| Q16881 | |||||||||
| P07093 | |||||||||
| P27487 | |||||||||
| P15144 | |||||||||
| Q9H5V8 | |||||||||
| P08729 | |||||||||
| Q04828 | |||||||||
| O94925 | |||||||||
| P08473 | |||||||||
| Q8IVL5 | |||||||||
| P35442 | |||||||||
| O60716 | |||||||||
| P08253 | |||||||||
| Q16822 | |||||||||
| Q9UJ72 | |||||||||
| Q9Y617 | |||||||||
| Q8WX93 | |||||||||
| Q32MZ4 | |||||||||
| Q6P179 | |||||||||
| P48681 | |||||||||
| O95340 | |||||||||
| P21580 | |||||||||
| Q00341 | |||||||||
| P49748 | |||||||||
| O43854 | |||||||||
| P07942 | |||||||||
| Q96KC8 | |||||||||
| Q96PD2 | |||||||||
| Q13418 | |||||||||
| Q7Z7G0 | |||||||||
| Q04446 | |||||||||
| P19022 | |||||||||
| O00469 | |||||||||
| Q8WUF5 | |||||||||
| Q14767 | |||||||||
| Q13308 | |||||||||
| P46940 | |||||||||
| Q9NZ08 | |||||||||
| O60488 | |||||||||
| P35222 | |||||||||
| Q9H4M9 | |||||||||
| Q9NZU5 | |||||||||
| Q15113 | |||||||||
| O94808 | |||||||||
| Q9UI42 | |||||||||
| Q15417 | |||||||||
| Q15582 | |||||||||
| P35908 | |||||||||
| P00750 | |||||||||
| Q9UHD8 | |||||||||
| P11047 | |||||||||
| Q8N6G6 | |||||||||
| Q05682 | |||||||||
| P17342 | |||||||||
| Q16363 | |||||||||
| Q9NR12 | |||||||||
| P05362 | |||||||||
| P00966 | |||||||||
| P05120 | |||||||||
| P15121 | |||||||||
| P04179 | |||||||||
| Q15785 | |||||||||
| O60271 | |||||||||
| Q9Y6N5 | |||||||||
| Q9P0V9 | |||||||||
| Q8IVF2 | |||||||||
| P01584 | |||||||||
| Q96AQ6 | |||||||||
| P54289 | |||||||||
| P13667 | |||||||||
| Q96HE7 | |||||||||
| P21810 | |||||||||
| Q16790 | |||||||||
| P23396 | |||||||||
| P01130 | |||||||||
| P51812 | |||||||||
| O95490 | |||||||||
| Q16222 | |||||||||
| Q7Z4N8 | |||||||||
| P08133 | |||||||||
| Q08431 | |||||||||
| P23142 | |||||||||
| Q01581 | |||||||||
| P10915 | |||||||||
| O75976 | |||||||||
| P23219 | |||||||||
| Q8IXK2 | |||||||||
| Q07954 | |||||||||
| P50225 | |||||||||
| P11413 | |||||||||
| Q5SSJ5 | |||||||||
| Q6PCE3 | |||||||||
| P05091 | |||||||||
| P49419 | |||||||||
| P41252 | |||||||||
| P50281 | |||||||||
| Q13618 | |||||||||
| Q00653 | |||||||||
| Q9BZG1 | |||||||||
| P11142 | |||||||||
| P63010 | |||||||||
| Q9UBG0 | |||||||||
| Q5GLZ8 | |||||||||
| P21266 | |||||||||
| Q9BS40 | |||||||||
| P35232 | |||||||||
| Q86VP6 | |||||||||
| P09601 | |||||||||
| Q8N8S7 | |||||||||
| Q16851 | |||||||||
| P28845 | |||||||||
| P26640 | |||||||||
| Q92626 | |||||||||
| P07686 | |||||||||
| P01583 | |||||||||
| Q96HH9 | |||||||||
| P48506 | |||||||||
| P47712 | |||||||||
| Q14314 | |||||||||
| Q53FA7 | |||||||||
| Q9H425 | |||||||||
| Q14204 | |||||||||
| P01033 | |||||||||
| Q92616 | |||||||||
| Q16666 | |||||||||
| Q99623 | |||||||||
| P23381 | |||||||||
| Q8N6Y2 | |||||||||
| P98155 | |||||||||
| P46977 | |||||||||
| Q86SQ0 | |||||||||
| Q70E73 | |||||||||
| Q6VY07 | |||||||||
| P41250 | |||||||||
| P56945 | |||||||||
| P29279 | |||||||||
| Q96C19 | |||||||||
| Q9UPN3 | |||||||||
| P26022 | |||||||||
| P00492 | |||||||||
| Q9BXS4 | |||||||||
| P50452 | |||||||||
| P05783 | |||||||||
| Q14980 | |||||||||
| Q9UBX5 | |||||||||
| O75094 | |||||||||
| Q06323 | |||||||||
| O14672 | |||||||||
| O00339 | |||||||||
| P52209 | |||||||||
| Q00325 | |||||||||
| P30044 | |||||||||
| P30740 | |||||||||
| P46734 | |||||||||
| P48307 | |||||||||
| P08648 | |||||||||
| O43175 | |||||||||
| O00116 |
