Selected Cell
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stat_data__min_2_Peptides
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| P57772 | P57772 | SELB_HUMAN | Selenocysteine-specific elongation factor (EC 3.6.5.-) (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific) | EEFSEC | selenocysteine incorporation [GO:0001514] | cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] | GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ribonucleoprotein complex binding [GO:0043021]; selenocysteine insertion sequence binding [GO:0035368]; translation elongation factor activity [GO:0003746]; tRNA binding [GO:0000049] | 7581.83820013043 | -0.197630191667936 | 0.0302394253297871 | 0.115272198566386 |
| Q8NF37 | Q8NF37 | PCAT1_HUMAN | Lysophosphatidylcholine acyltransferase 1 (LPC acyltransferase 1) (LPCAT-1) (LysoPC acyltransferase 1) (EC 2.3.1.23) (1-acylglycerol-3-phosphate O-acyltransferase) (EC 2.3.1.51) (1-acylglycerophosphocholine O-acyltransferase) (1-alkenylglycerophosphocholine O-acyltransferase) (EC 2.3.1.25) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acetyl-CoA:lyso-platelet-activating factor acetyltransferase) (Acetyl-CoA:lyso-PAF acetyltransferase) (Lyso-PAF acetyltransferase) (LysoPAFAT) (Acyltransferase-like 2) (Phosphonoformate immuno-associated protein 3) | LPCAT1 | negative regulation of phosphatidylcholine biosynthetic process [GO:2001246]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phospholipid biosynthetic process [GO:0008654]; positive regulation of protein catabolic process [GO:0045732]; protein catabolic process [GO:0030163]; retina development in camera-type eye [GO:0060041]; surfactant homeostasis [GO:0043129] | azurophil granule membrane [GO:0035577]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lipid droplet [GO:0005811]; membrane [GO:0016020]; plasma membrane [GO:0005886] | 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-alkenylglycerophosphocholine O-acyltransferase activity [GO:0047159]; 1-alkylglycerophosphocholine O-acetyltransferase activity [GO:0047192]; 1-alkylglycerophosphocholine O-acyltransferase activity [GO:0047191]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; calcium ion binding [GO:0005509]; lysophosphatidic acid acyltransferase activity [GO:0042171]; plasmalogen synthase activity [GO:0050200] | 9271.96095166192 | 0.264572836899584 | 0.0302523401461731 | 0.115272198566386 |
| P01023 | P01023 | A2MG_HUMAN | Alpha-2-macroglobulin (Alpha-2-M) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5) | A2M | acute inflammatory response to antigenic stimulus [GO:0002438]; acute-phase response [GO:0006953]; embryonic liver development [GO:1990402]; luteinization [GO:0001553]; negative regulation of complement activation, lectin pathway [GO:0001869]; response to carbon dioxide [GO:0010037]; response to glucocorticoid [GO:0051384]; response to nutrient [GO:0007584]; response to prostaglandin E [GO:0034695]; stem cell differentiation [GO:0048863] | blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093] | brain-derived neurotrophic factor binding [GO:0048403]; calcium-dependent protein binding [GO:0048306]; endopeptidase inhibitor activity [GO:0004866]; enzyme binding [GO:0019899]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; interleukin-1 binding [GO:0019966]; interleukin-8 binding [GO:0019959]; nerve growth factor binding [GO:0048406]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]; signaling receptor binding [GO:0005102]; tumor necrosis factor binding [GO:0043120] | 17294.0353526456 | -0.477525124960069 | 0.0303839656105184 | 0.115695933568009 |
| Q9NPA0 | Q9NPA0 | EMC7_HUMAN | Endoplasmic reticulum membrane protein complex subunit 7 (ER membrane protein complex subunit 7) | EMC7 | protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816] | EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] | carbohydrate binding [GO:0030246] | 65367.31268137785 | 0.377281527911133 | 0.0304640215316039 | 0.115922865008776 |
| Q15397 | Q15397 | PUM3_HUMAN | Pumilio homolog 3 (HBV X-transactivated gene 5 protein) (HBV XAg-transactivated protein 5) (Minor histocompatibility antigen HA-8) (HLA-HA8) | PUM3 | regulation of protein ADP-ribosylation [GO:0010835]; regulation of translation [GO:0006417] | chromosome [GO:0005694]; endoplasmic reticulum [GO:0005783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] | DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] | 8898.742598174504 | -0.300627337987203 | 0.0306742386571546 | 0.116566221483191 |
| Q9H496 | Q9H496 | IFG15_HUMAN | Torsin-1A-interacting protein 2, isoform IFRG15 (15 kDa interferon-responsive protein) (IFRG15) | TOR1AIP2 | 5844.02683828916 | 1.20830971836101 | 0.030661408107053 | 0.116566221483191 | |||
| Q9Y5K8 | Q9Y5K8 | VATD_HUMAN | V-type proton ATPase subunit D (V-ATPase subunit D) (V-ATPase 28 kDa accessory protein) (Vacuolar proton pump subunit D) | ATP6V1D | cilium assembly [GO:0060271]; endosomal lumen acidification [GO:0048388]; Golgi lumen acidification [GO:0061795]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; protein localization to cilium [GO:0061512]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035] | centrosome [GO:0005813]; cilium [GO:0005929]; clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extrinsic component of synaptic vesicle membrane [GO:0098850]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; specific granule membrane [GO:0035579]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221] | proton-transporting ATPase activity, rotational mechanism [GO:0046961] | 40200.83597444555 | 0.274349139626835 | 0.0307595621313614 | 0.116733877452307 |
| P33947 | P33947 | ERD22_HUMAN | ER lumen protein-retaining receptor 2 (ERD2-like protein 1) (ELP-1) (KDEL endoplasmic reticulum protein retention receptor 2) (KDEL receptor 2) | KDELR2 | endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; maintenance of protein localization in endoplasmic reticulum [GO:0035437]; protein retention in ER lumen [GO:0006621]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890] | cis-Golgi network [GO:0005801]; COPI-coated vesicle membrane [GO:0030663]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; transport vesicle [GO:0030133] | ER retention sequence binding [GO:0046923]; KDEL sequence binding [GO:0005046] | 3165.41894884658 | -0.546812096352785 | 0.0307491712194181 | 0.116733877452307 |
| Q9Y2B9 | Q9Y2B9 | IPKG_HUMAN | cAMP-dependent protein kinase inhibitor gamma (PKI-gamma) | PKIG | negative regulation of protein import into nucleus [GO:0042308]; negative regulation of transcription by RNA polymerase II [GO:0000122] | cytoplasm [GO:0005737]; nucleus [GO:0005634] | cAMP-dependent protein kinase inhibitor activity [GO:0004862] | 15684.3036103784 | 0.502958406234613 | 0.0307948639396089 | 0.11678962455276 |
| Q5D862 | Q5D862 | FILA2_HUMAN | Filaggrin-2 (FLG-2) (Intermediate filament-associated and psoriasis-susceptibility protein) (Ifapsoriasin) | FLG2 | cell adhesion [GO:0007155]; epidermis morphogenesis [GO:0048730]; establishment of skin barrier [GO:0061436] | cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; keratohyalin granule [GO:0036457]; nucleus [GO:0005634]; tertiary granule lumen [GO:1904724] | calcium ion binding [GO:0005509]; structural molecule activity [GO:0005198]; transition metal ion binding [GO:0046914] | 1367.671183992385 | -3.93439606334517 | 0.0309001623218242 | 0.117110581749469 |
| O14974 | O14974 | MYPT1_HUMAN | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | PPP1R12A | cellular response to xenobiotic stimulus [GO:0071466]; centrosome cycle [GO:0007098]; mitotic cell cycle [GO:0000278]; negative regulation of catalytic activity [GO:0043086]; positive regulation of myosin-light-chain-phosphatase activity [GO:0035508]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein dephosphorylation [GO:0006470]; regulation of cell adhesion [GO:0030155]; regulation of myosin-light-chain-phosphatase activity [GO:0035507]; regulation of nucleocytoplasmic transport [GO:0046822]; signal transduction [GO:0007165] | A band [GO:0031672]; actin cytoskeleton [GO:0015629]; centrosome [GO:0005813]; contractile fiber [GO:0043292]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; PTW/PP1 phosphatase complex [GO:0072357]; stress fiber [GO:0001725]; Z disc [GO:0030018] | 14-3-3 protein binding [GO:0071889]; enzyme inhibitor activity [GO:0004857]; phosphatase regulator activity [GO:0019208]; protein kinase binding [GO:0019901] | 34283.849076811995 | -0.127282112133509 | 0.0309839862244811 | 0.117349776703148 |
| P29692 | P29692 | EF1D_HUMAN | Elongation factor 1-delta (EF-1-delta) (Antigen NY-CO-4) | EEF1D | cellular response to heat [GO:0034605]; cellular response to ionizing radiation [GO:0071479]; cytoplasmic translational elongation [GO:0002182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; translational elongation [GO:0006414] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation elongation factor 1 complex [GO:0005853]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | cadherin binding [GO:0045296]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; guanyl-nucleotide exchange factor activity [GO:0005085]; heat shock protein binding [GO:0031072]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; translation elongation factor activity [GO:0003746]; translation factor activity, RNA binding [GO:0008135] | 335559.622821321 | 0.27026032252723 | 0.0310448853690262 | 0.117501884102139 |
| Q8IX12 | Q8IX12 | CCAR1_HUMAN | Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain) | CCAR1 | apoptotic process [GO:0006915]; cell cycle [GO:0007049]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] | nuclear envelope lumen [GO:0005641]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] | nuclear receptor coactivator activity [GO:0030374]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630] | 7638.524688119571 | -0.199789693108662 | 0.0311173378776026 | 0.117617372824529 |
| Q8N0U8 | Q8N0U8 | VKORL_HUMAN | Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1-like protein 1) (EC 1.17.4.4) | VKORC1L1 | cellular response to oxidative stress [GO:0034599]; peptidyl-glutamic acid carboxylation [GO:0017187]; vitamin K metabolic process [GO:0042373] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] | quinone binding [GO:0048038]; vitamin-K-epoxide reductase (warfarin-sensitive) activity [GO:0047057] | 15136.9249187391 | -1.33857058374903 | 0.0311157925908594 | 0.117617372824529 |
| Q9UP95 | Q9UP95 | S12A4_HUMAN | Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1) | SLC12A4 | ammonium import across plasma membrane [GO:0140157]; cell volume homeostasis [GO:0006884]; chemical synaptic transmission [GO:0007268]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; monoatomic ion transport [GO:0006811]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805] | lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202] | ammonium transmembrane transporter activity [GO:0008519]; ATP binding [GO:0005524]; potassium:chloride symporter activity [GO:0015379]; protein kinase binding [GO:0019901] | 9003.502873092584 | -0.190796962042426 | 0.0311625337826792 | 0.117632855704637 |
| P30049 | P30049 | ATPD_HUMAN | ATP synthase subunit delta, mitochondrial (ATP synthase F1 subunit delta) (F-ATPase delta subunit) | ATP5F1D | aerobic respiration [GO:0009060]; mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to copper ion [GO:0046688] | mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) [GO:0000275]; mitochondrion [GO:0005739] | proton-transporting ATP synthase activity, rotational mechanism [GO:0046933] | 40904.45152574585 | -0.542418821409602 | 0.0312151874453923 | 0.117734453783545 |
| Q9BWJ5 | Q9BWJ5 | SF3B5_HUMAN | Splicing factor 3B subunit 5 (SF3b5) (Pre-mRNA-splicing factor SF3b 10 kDa subunit) | SF3B5 | mRNA splicing, via spliceosome [GO:0000398]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; U2-type prespliceosome assembly [GO:1903241] | nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; SAGA complex [GO:0000124]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684] | RNA binding [GO:0003723]; splicing factor binding [GO:1990935] | 23545.966805550197 | 0.379438177959152 | 0.0312310067131429 | 0.117734453783545 |
| Q8WTW3 | Q8WTW3 | COG1_HUMAN | Conserved oligomeric Golgi complex subunit 1 (COG complex subunit 1) (Component of oligomeric Golgi complex 1) | COG1 | glycosylation [GO:0070085]; Golgi organization [GO:0007030]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301] | Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; trans-Golgi network membrane [GO:0032588] | 5792.56306272193 | -0.330064156802611 | 0.0315755353875753 | 0.118954111373671 | |
| O00161 | O00161 | SNP23_HUMAN | Synaptosomal-associated protein 23 (SNAP-23) (Vesicle-membrane fusion protein SNAP-23) | SNAP23 | exocytosis [GO:0006887]; histamine secretion by mast cell [GO:0002553]; membrane fusion [GO:0061025]; post-Golgi vesicle-mediated transport [GO:0006892]; protein transport [GO:0015031]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle priming [GO:0016082]; vesicle targeting [GO:0006903] | adherens junction [GO:0005912]; azurophil granule [GO:0042582]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; SNARE complex [GO:0031201]; specific granule [GO:0042581]; specific granule membrane [GO:0035579]; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex [GO:0070032]; tertiary granule membrane [GO:0070821] | SNAP receptor activity [GO:0005484]; syntaxin binding [GO:0019905]; syntaxin-1 binding [GO:0017075] | 53096.246300671555 | 0.273564774336228 | 0.0320533109013605 | 0.120513642712083 |
| Q9NR19 | Q9NR19 | ACSA_HUMAN | Acetyl-coenzyme A synthetase, cytoplasmic (EC 6.2.1.1) (Acetate--CoA ligase) (Acetyl-CoA synthetase) (ACS) (AceCS) (Acetyl-CoA synthetase 1) (AceCS1) (Acyl-CoA synthetase short-chain family member 2) (Acyl-activating enzyme) (Propionate--CoA ligase) (EC 6.2.1.17) | ACSS2 | acetate biosynthetic process [GO:0019413]; acetyl-CoA biosynthetic process [GO:0006085]; acetyl-CoA biosynthetic process from acetate [GO:0019427]; ethanol oxidation [GO:0006069]; lipid biosynthetic process [GO:0008610]; long-term memory [GO:0007616]; propionate biosynthetic process [GO:0019542] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634] | acetate-CoA ligase activity [GO:0003987]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; propionate-CoA ligase activity [GO:0050218]; transcription coactivator activity [GO:0003713] | 15484.809013646449 | 0.165954139976497 | 0.0323097955738472 | 0.121269474346761 |
| O75380 | O75380 | NDUS6_HUMAN | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (Complex I-13kD-A) (CI-13kD-A) (NADH-ubiquinone oxidoreductase 13 kDa-A subunit) | NDUFS6 | aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776] | mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747] | electron transfer activity [GO:0009055]; NADH dehydrogenase (ubiquinone) activity [GO:0008137] | 17120.5046364426 | 0.351482461747953 | 0.03231855034656 | 0.121269474346761 |
| P38646 | P38646 | GRP75_HUMAN | Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) | HSPA9 | chaperone cofactor-dependent protein refolding [GO:0051085]; erythrocyte differentiation [GO:0030218]; inner mitochondrial membrane organization [GO:0007007]; intracellular protein transport [GO:0006886]; iron-sulfur cluster assembly [GO:0016226]; negative regulation of apoptotic process [GO:0043066]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; negative regulation of hemopoiesis [GO:1903707]; protein export from nucleus [GO:0006611]; protein refolding [GO:0042026]; regulation of erythrocyte differentiation [GO:0045646] | cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; MIB complex [GO:0140275]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; SAM complex [GO:0001401]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; heat shock protein binding [GO:0031072]; protein folding chaperone [GO:0044183]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082] | 130344.014253035 | 0.116387478172234 | 0.032429868184584 | 0.121606640062113 |
| Q8N4L2 | Q8N4L2 | PP4P2_HUMAN | Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 2 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase II) (Transmembrane protein 55A) | PIP4P2 | negative regulation of phagocytosis [GO:0050765]; phosphatidylinositol dephosphorylation [GO:0046856] | late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886] | phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity [GO:0034597] | 23062.52076537715 | -0.495800360886292 | 0.0325504028241202 | 0.121816765126463 |
| Q9BTV4 | Q9BTV4 | TMM43_HUMAN | Transmembrane protein 43 (Protein LUMA) | TMEM43 | innate immune response [GO:0045087]; lipid metabolic process [GO:0006629]; nuclear membrane organization [GO:0071763] | endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; plasma membrane [GO:0005886] | identical protein binding [GO:0042802]; protein self-association [GO:0043621] | 83733.52212694069 | 0.235223262257521 | 0.032702689092183 | 0.122305898611425 |
| Q9BX95 | Q9BX95 | SGPP1_HUMAN | Sphingosine-1-phosphate phosphatase 1 (SPPase1) (Spp1) (hSPP1) (hSPPase1) (EC 3.1.3.-) (Sphingosine-1-phosphatase 1) (Sphingosine-1-phosphate phosphohydrolase 1) (SPP-1) | SGPP1 | ER to Golgi ceramide transport [GO:0035621]; extrinsic apoptotic signaling pathway [GO:0097191]; intrinsic apoptotic signaling pathway [GO:0097193]; phospholipid dephosphorylation [GO:0046839]; regulation of epidermis development [GO:0045682]; regulation of keratinocyte differentiation [GO:0045616]; sphinganine-1-phosphate metabolic process [GO:0006668]; sphingolipid catabolic process [GO:0030149]; sphingosine metabolic process [GO:0006670] | endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] | dihydrosphingosine-1-phosphate phosphatase activity [GO:0070780]; sphingosine-1-phosphate phosphatase activity [GO:0042392] | 6675.54231671831 | -0.747041704016499 | 0.032788699342047 | 0.122546682369418 |
| Q02127 | Q02127 | PYRD_HUMAN | Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (EC 1.3.5.2) (Dihydroorotate oxidase) | DHODH | 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; pyrimidine ribonucleotide biosynthetic process [GO:0009220]; UDP biosynthetic process [GO:0006225] | cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] | dihydroorotase activity [GO:0004151]; dihydroorotate dehydrogenase (quinone) activity [GO:0106430]; dihydroorotate dehydrogenase activity [GO:0004152] | 6961.66047156123 | 0.657426073120148 | 0.0330743083151599 | 0.123451272011657 |
| O14874 | O14874 | BCKD_HUMAN | Branched-chain alpha-ketoacid dehydrogenase kinase (BCKDH kinase) (BCKDHKIN) (BDK) (EC 2.7.11.1) ([3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial) (EC 2.7.11.4) | BCKDK | amino acid catabolic process [GO:0009063]; branched-chain amino acid catabolic process [GO:0009083]; lipid biosynthetic process [GO:0008610]; negative regulation of cellular amino acid metabolic process [GO:0045763]; phosphorylation [GO:0016310]; regulation of glucose metabolic process [GO:0010906] | mitochondrial matrix [GO:0005759]; mitochondrial oxoglutarate dehydrogenase complex [GO:0009353]; mitochondrion [GO:0005739] | [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity [GO:0047323]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine phosphatase activity [GO:0004722]; pyruvate dehydrogenase (acetyl-transferring) kinase activity [GO:0004740] | 2979.387867972005 | 1.39974538965623 | 0.0336391559700299 | 0.125422674143288 |
| Q9NS00 | Q9NS00 | C1GLT_HUMAN | Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (EC 2.4.1.122) (B3Gal-T8) (Core 1 O-glycan T-synthase) (Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1) (Beta-1,3-galactosyltransferase) (Core 1 beta1,3-galactosyltransferase 1) (C1GalT1) (Core 1 beta3-Gal-T1) | C1GALT1 | angiogenesis [GO:0001525]; intestinal epithelial cell development [GO:0060576]; kidney development [GO:0001822]; protein O-linked glycosylation [GO:0006493] | Golgi membrane [GO:0000139]; membrane [GO:0016020] | glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity [GO:0016263]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166] | 11766.6280054938 | 0.4552761485939 | 0.0336688823459127 | 0.125422674143288 |
| Q13724 | Q13724 | MOGS_HUMAN | Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Processing A-glucosidase I) | MOGS | oligosaccharide metabolic process [GO:0009311]; protein folding [GO:0006457]; protein N-linked glycosylation [GO:0006487]; viral protein processing [GO:0019082] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020] | Glc3Man9GlcNAc2 oligosaccharide glucosidase activity [GO:0004573]; glucosidase activity [GO:0015926] | 44347.961481991006 | -0.136731533305238 | 0.033667772361676 | 0.125422674143288 |
| Q8WXI4 | Q8WXI4 | ACO11_HUMAN | Acyl-coenzyme A thioesterase 11 (Acyl-CoA thioesterase 11) (EC 3.1.2.-) (Acyl-CoA thioester hydrolase 11) (Adipose-associated thioesterase) (Brown fat-inducible thioesterase) (BFIT) (Palmitoyl-coenzyme A thioesterase) (EC 3.1.2.2) | ACOT11 | acyl-CoA metabolic process [GO:0006637]; fatty acid metabolic process [GO:0006631]; intracellular signal transduction [GO:0035556]; negative regulation of cold-induced thermogenesis [GO:0120163]; response to cold [GO:0009409]; response to temperature stimulus [GO:0009266] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759] | carboxylic ester hydrolase activity [GO:0052689]; fatty acyl-CoA hydrolase activity [GO:0047617]; lipid binding [GO:0008289]; long-chain fatty acyl-CoA hydrolase activity [GO:0052816] | 2715.728769649615 | 0.647827427631194 | 0.0338772511359523 | 0.12611596907773 |
| Q9NWM8 | Q9NWM8 | FKB14_HUMAN | Peptidyl-prolyl cis-trans isomerase FKBP14 (PPIase FKBP14) (EC 5.2.1.8) (22 kDa FK506-binding protein) (22 kDa FKBP) (FKBP-22) (FK506-binding protein 14) (FKBP-14) (Rotamase) | FKBP14 | endoplasmic reticulum lumen [GO:0005788] | calcium ion binding [GO:0005509]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755] | 13528.243496850399 | 0.537773615383816 | 0.0339350267910371 | 0.126248103609991 | |
| B7ZAQ6;P0CG08 | B7ZAQ6 | GPHRA_HUMAN | Golgi pH regulator A (Protein GPR89A) (Putative MAPK-activating protein PM01) (Putative NF-kappa-B-activating protein 90) | GPR89A | intracellular pH reduction [GO:0051452]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein transport [GO:0015031]; response to abscisic acid [GO:0009737]; T cell differentiation [GO:0030217] | Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; monoatomic ion channel complex [GO:0034702] | abscisic acid binding [GO:0010427]; voltage-gated monoatomic anion channel activity [GO:0008308] | 5759.157461481145 | -1.17533010620514 | 0.0342957020079264 | 0.127422588575024 |
| Q07021 | Q07021 | C1QBP_HUMAN | Complement component 1 Q subcomponent-binding protein, mitochondrial (ASF/SF2-associated protein p32) (Glycoprotein gC1qBP) (C1qBP) (Hyaluronan-binding protein 1) (Mitochondrial matrix protein p32) (gC1q-R protein) (p33) (SF2AP32) | C1QBP | apoptotic process [GO:0006915]; complement activation, classical pathway [GO:0006958]; cytosolic ribosome assembly [GO:0042256]; immune response [GO:0006955]; innate immune response [GO:0045087]; mRNA processing [GO:0006397]; negative regulation of defense response to virus [GO:0050687]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of MDA-5 signaling pathway [GO:0039534]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell adhesion [GO:0045785]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of mitochondrial translation [GO:0070131]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of trophoblast cell migration [GO:1901165]; regulation of complement activation [GO:0030449]; RNA splicing [GO:0008380] | cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | adrenergic receptor binding [GO:0031690]; complement component C1q complex binding [GO:0001849]; enzyme inhibitor activity [GO:0004857]; hyaluronic acid binding [GO:0005540]; kininogen binding [GO:0030984]; mitochondrial ribosome binding [GO:0097177]; mRNA binding [GO:0003729]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134] | 63468.52823042619 | 0.387073864208472 | 0.034357434719633 | 0.127568299555335 |
| O43556 | O43556 | SGCE_HUMAN | Epsilon-sarcoglycan (Epsilon-SG) | SGCE | cell-matrix adhesion [GO:0007160]; muscle organ development [GO:0007517] | cytoskeleton [GO:0005856]; dendrite membrane [GO:0032590]; dystrophin-associated glycoprotein complex [GO:0016010]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383] | 3771.8317541754896 | -2.27412199748261 | 0.0344248574907314 | 0.12773493290274 | |
| Q6UWE0 | Q6UWE0 | LRSM1_HUMAN | E3 ubiquitin-protein ligase LRSAM1 (EC 2.3.2.27) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (RING-type E3 ubiquitin transferase LRSAM1) (Tsg101-associated ligase) (hTAL) | LRSAM1 | autophagy [GO:0006914]; negative regulation of endocytosis [GO:0045806]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of xenophagy [GO:1904417]; protein autoubiquitination [GO:0051865]; protein catabolic process [GO:0030163]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent endocytosis [GO:0070086]; viral budding [GO:0046755] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] | metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] | 9559.735167442024 | -0.28214029102724 | 0.0346087924813262 | 0.128249455983777 |
| Q00688 | Q00688 | FKBP3_HUMAN | Peptidyl-prolyl cis-trans isomerase FKBP3 (PPIase FKBP3) (EC 5.2.1.8) (25 kDa FK506-binding protein) (25 kDa FKBP) (FKBP-25) (FK506-binding protein 3) (FKBP-3) (Immunophilin FKBP25) (Rapamycin-selective 25 kDa immunophilin) (Rotamase) | FKBP3 | nucleus [GO:0005634] | FK506 binding [GO:0005528]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723]; signaling receptor activity [GO:0038023] | 142345.149219615 | 0.302480723245147 | 0.0346774351465462 | 0.12841983499368 | |
| P38936 | P38936 | CDN1A_HUMAN | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21) | CDKN1A | animal organ regeneration [GO:0031100]; cellular response to amino acid starvation [GO:0034198]; cellular response to extracellular stimulus [GO:0031668]; cellular response to gamma radiation [GO:0071480]; cellular response to heat [GO:0034605]; cellular response to ionizing radiation [GO:0071479]; cellular response to UV-B [GO:0071493]; cellular senescence [GO:0090398]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; fibroblast proliferation [GO:0048144]; G1/S transition of mitotic cell cycle [GO:0000082]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; intestinal epithelial cell maturation [GO:0060574]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiac muscle tissue regeneration [GO:1905179]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein kinase activity [GO:1904030]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of gene expression [GO:0010629]; negative regulation of phosphorylation [GO:0042326]; negative regulation of protein binding [GO:0032091]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; oncogene-induced cell senescence [GO:0090402]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of DNA replication [GO:0045740]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of programmed cell death [GO:0043068]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; protein import into nucleus [GO:0006606]; Ras protein signal transduction [GO:0007265]; regulation of cell cycle [GO:0051726]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; replicative senescence [GO:0090399]; response to aldosterone [GO:1904044]; response to arsenic-containing substance [GO:0046685]; response to corticosterone [GO:0051412]; response to hyperoxia [GO:0055093]; response to organonitrogen compound [GO:0010243]; response to toxic substance [GO:0009636]; response to X-ray [GO:0010165]; response to xenobiotic stimulus [GO:0009410]; stress-induced premature senescence [GO:0090400]; tissue regeneration [GO:0042246]; wound healing [GO:0042060] | cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PCNA-p21 complex [GO:0070557]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991] | cyclin binding [GO:0030332]; cyclin-dependent protein kinase activating kinase activity [GO:0019912]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; metal ion binding [GO:0046872]; molecular function activator activity [GO:0140677]; molecular function inhibitor activity [GO:0140678]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; protein sequestering activity [GO:0140311]; protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625] | 15367.02458027855 | -0.740008853275605 | 0.0347104557495174 | 0.128458159553733 |
| Q96EY8 | Q96EY8 | MMAB_HUMAN | Corrinoid adenosyltransferase MMAB (EC 2.5.1.-) (ATP:co(I)rrinoid adenosyltransferase MMAB) (Methylmalonic aciduria type B protein) | MMAB | cobalamin metabolic process [GO:0009235] | mitochondrial matrix [GO:0005759] | ATP binding [GO:0005524]; cobalamin binding [GO:0031419]; corrinoid adenosyltransferase activity [GO:0008817]; transferase activity, transferring alkyl or aryl (other than methyl) groups [GO:0016765] | 11164.06786012475 | 0.365998377123758 | 0.0347336913636253 | 0.128460244951894 |
| Q92925 | Q92925 | SMRD2_HUMAN | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 (60 kDa BRG-1/Brm-associated factor subunit B) (BRG1-associated factor 60B) (BAF60B) | SMARCD2 | chromatin remodeling [GO:0006338]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357] | bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; kinetochore [GO:0000776]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514] | transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] | 7918.822654441745 | 0.184021721418741 | 0.0348113818615079 | 0.128579719444135 |
| Q12929 | Q12929 | EPS8_HUMAN | Epidermal growth factor receptor kinase substrate 8 | EPS8 | actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; actin polymerization-dependent cell motility [GO:0070358]; adult locomotory behavior [GO:0008344]; barbed-end actin filament capping [GO:0051016]; behavioral response to ethanol [GO:0048149]; cellular response to leukemia inhibitory factor [GO:1990830]; dendritic cell migration [GO:0036336]; exit from mitosis [GO:0010458]; positive regulation of ruffle assembly [GO:1900029]; Rac protein signal transduction [GO:0016601]; regulation of actin filament length [GO:0030832]; regulation of cell shape [GO:0008360]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of Rho protein signal transduction [GO:0035023]; Rho protein signal transduction [GO:0007266] | brush border [GO:0005903]; cell cortex [GO:0005938]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; ruffle membrane [GO:0032587]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]; vesicle [GO:0031982] | actin binding [GO:0003779]; small GTPase binding [GO:0031267] | 6908.11020363621 | -0.279242159207765 | 0.0348708833434833 | 0.128715586334968 |
| Q9BRQ8 | Q9BRQ8 | FSP1_HUMAN | Ferroptosis suppressor protein 1 (FSP1) (EC 1.6.5.-) (Apoptosis-inducing factor homologous mitochondrion-associated inducer of death) (AMID) (p53-responsive gene 3 protein) | AIFM2 | apoptotic mitochondrial changes [GO:0008637]; cellular detoxification [GO:1990748]; negative regulation of ferroptosis [GO:0110076]; positive regulation of apoptotic process [GO:0043065]; regulation of cellular response to oxidative stress [GO:1900407]; ubiquinone metabolic process [GO:0006743]; vitamin K metabolic process [GO:0042373] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; lipid droplet [GO:0005811]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | DNA binding [GO:0003677]; electron-transferring-flavoprotein dehydrogenase activity [GO:0004174]; flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655] | 6303.265480389915 | -3.13213889663598 | 0.0349408170066999 | 0.128738975578357 |
| Q86V88 | Q86V88 | MGDP1_HUMAN | Magnesium-dependent phosphatase 1 (MDP-1) (EC 3.1.3.-) (EC 3.1.3.48) | MDP1 | acid phosphatase activity [GO:0003993]; metal ion binding [GO:0046872]; protein tyrosine phosphatase activity [GO:0004725] | 12544.742592679351 | -0.655197880623946 | 0.0349453837697693 | 0.128738975578357 | ||
| P61604 | P61604 | CH10_HUMAN | 10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10) (Early-pregnancy factor) (EPF) (Heat shock protein family E member 1) | HSPE1 | activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; chaperone cofactor-dependent protein refolding [GO:0051085]; osteoblast differentiation [GO:0001649]; protein folding [GO:0006457]; response to unfolded protein [GO:0006986] | extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] | ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082] | 238305.686520571 | -0.369344596453739 | 0.0351752699469157 | 0.129478123824391 |
| Q96ME7 | Q96ME7 | ZN512_HUMAN | Zinc finger protein 512 | ZNF512 | nucleus [GO:0005634] | DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; zinc ion binding [GO:0008270] | 6281.90574809117 | -0.492047526400284 | 0.03519172444221 | 0.129478123824391 | |
| Q96JJ3 | Q96JJ3 | ELMO2_HUMAN | Engulfment and cell motility protein 2 (Protein ced-12 homolog A) (hCed-12A) | ELMO2 | actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; cell chemotaxis [GO:0060326]; cell motility [GO:0048870]; phagocytosis [GO:0006909] | cytosol [GO:0005829]; membrane [GO:0016020] | receptor tyrosine kinase binding [GO:0030971]; SH3 domain binding [GO:0017124] | 12541.13624437275 | -0.113698786135909 | 0.0354948003910878 | 0.130508461399029 |
| Q9UJZ1 | Q9UJZ1 | STML2_HUMAN | Stomatin-like protein 2, mitochondrial (SLP-2) (EPB72-like protein 2) (Paraprotein target 7) (Paratarg-7) | STOML2 | CD4-positive, alpha-beta T cell activation [GO:0035710]; intracellular calcium ion homeostasis [GO:0006874]; lipid localization [GO:0010876]; mitochondrial protein processing [GO:0034982]; mitochondrion organization [GO:0007005]; positive regulation of interleukin-2 production [GO:0032743]; protein complex oligomerization [GO:0051259]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; stress-induced mitochondrial fusion [GO:1990046]; T cell receptor signaling pathway [GO:0050852] | actin cytoskeleton [GO:0015629]; immunological synapse [GO:0001772]; membrane raft [GO:0045121]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] | cardiolipin binding [GO:1901612]; GTPase binding [GO:0051020]; T cell receptor binding [GO:0042608] | 49692.17766039925 | 0.216704634225836 | 0.0359003399732729 | 0.131828468106652 |
| P54725 | P54725 | RD23A_HUMAN | UV excision repair protein RAD23 homolog A (HR23A) (hHR23A) | RAD23A | nucleotide-excision repair [GO:0006289]; positive regulation of cell cycle [GO:0045787]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of viral genome replication [GO:0045070]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein destabilization [GO:0031648]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; protein-containing complex [GO:0032991] | damaged DNA binding [GO:0003684]; kinase binding [GO:0019900]; polyubiquitin modification-dependent protein binding [GO:0031593]; proteasome binding [GO:0070628]; single-stranded DNA binding [GO:0003697]; ubiquitin binding [GO:0043130]; ubiquitin-specific protease binding [GO:1990381] | 21342.7877014094 | 0.291980334268288 | 0.036174061110303 | 0.132661637702898 |
| Q9UJX2 | Q9UJX2 | CDC23_HUMAN | Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8) | CDC23 | anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; mitotic cell cycle [GO:0000278]; mitotic metaphase chromosome alignment [GO:0007080]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein K11-linked ubiquitination [GO:0070979]; protein ubiquitination [GO:0016567]; regulation of exit from mitosis [GO:0007096]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; ubiquitin-dependent protein catabolic process [GO:0006511] | anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] | ubiquitin-protein transferase activity [GO:0004842] | 5445.940288537569 | -0.301923851557551 | 0.0361979010839789 | 0.132663200221102 |
| Q15434 | Q15434 | RBMS2_HUMAN | RNA-binding motif, single-stranded-interacting protein 2 (Suppressor of CDC2 with RNA-binding motif 3) | RBMS2 | RNA processing [GO:0006396] | cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] | mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723] | 15947.124115859398 | -0.178179022412919 | 0.0363364298236904 | 0.133084816665178 |
| Q15056 | Q15056 | IF4H_HUMAN | Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein) | EIF4H | developmental growth [GO:0048589]; regulation of translational initiation [GO:0006446]; sexual reproduction [GO:0019953] | cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471] | cadherin binding [GO:0045296]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743] | 185151.832740263 | 0.433861451156847 | 0.0364173752824778 | 0.133295121673462 |
| Q9H0B6 | Q9H0B6 | KLC2_HUMAN | Kinesin light chain 2 (KLC 2) | KLC2 | lysosome localization [GO:0032418]; microtubule-based movement [GO:0007018] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; kinesin I complex [GO:0016938]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] | cadherin binding [GO:0045296]; kinesin binding [GO:0019894] | 25817.5123665181 | 0.140318685442821 | 0.0364921959222912 | 0.133482751514333 |
| P62306 | P62306 | RUXF_HUMAN | Small nuclear ribonucleoprotein F (snRNP-F) (Sm protein F) (Sm-F) (SmF) | SNRPF | 7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241] | catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; U7 snRNP [GO:0005683] | RNA binding [GO:0003723] | 9252.404055249975 | -1.07264179164679 | 0.0365987433057238 | 0.133786115851762 |
| Q9Y3A3 | Q9Y3A3 | PHOCN_HUMAN | MOB-like protein phocein (2C4D) (Class II mMOB1) (Mob1 homolog 3) (Mob3) (Mps one binder kinase activator-like 3) (Preimplantation protein 3) | MOB4 | cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471] | kinase binding [GO:0019900]; metal ion binding [GO:0046872] | 11242.16878648065 | 0.335466761578668 | 0.0370132152942474 | 0.135213976697102 | |
| Q13510 | Q13510 | ASAH1_HUMAN | Acid ceramidase (AC) (ACDase) (Acid CDase) (EC 3.5.1.23) (Acylsphingosine deacylase) (Glycosylceramide deacylase) (EC 3.5.1.109) (N-acylethanolamine hydrolase ASAH1) (EC 3.5.1.-) (N-acylsphingosine amidohydrolase) (Putative 32 kDa heart protein) (PHP32) [Cleaved into: Acid ceramidase subunit alpha; Acid ceramidase subunit beta] | ASAH1 | cellular response to tumor necrosis factor [GO:0071356]; ceramide biosynthetic process [GO:0046513]; ceramide catabolic process [GO:0046514]; fatty acid metabolic process [GO:0006631]; keratinocyte differentiation [GO:0030216]; regulation of programmed necrotic cell death [GO:0062098]; regulation of steroid biosynthetic process [GO:0050810]; sphingosine biosynthetic process [GO:0046512] | extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; nucleus [GO:0005634]; tertiary granule lumen [GO:1904724] | ceramidase activity [GO:0102121]; fatty acid amide hydrolase activity [GO:0017064]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]; N-acylsphingosine amidohydrolase activity [GO:0017040]; nuclear receptor binding [GO:0016922]; transcription corepressor activity [GO:0003714] | 85508.7225466557 | 0.241043130288787 | 0.037450827792036 | 0.136636439323681 |
| Q9UJ70 | Q9UJ70 | NAGK_HUMAN | N-acetyl-D-glucosamine kinase (N-acetylglucosamine kinase) (EC 2.7.1.59) (GlcNAc kinase) (Muramyl dipeptide kinase) (EC 2.7.1.-) (N-acetyl-D-mannosamine kinase) (EC 2.7.1.60) | NAGK | defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; N-acetylglucosamine metabolic process [GO:0006044]; N-acetylmannosamine metabolic process [GO:0006051]; N-acetylneuraminate catabolic process [GO:0019262]; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070434]; response to muramyl dipeptide [GO:0032495] | cytosol [GO:0005829]; extracellular exosome [GO:0070062] | ATP binding [GO:0005524]; muramyl dipeptide kinase activity [GO:0160047]; N-acetylglucosamine kinase activity [GO:0045127] | 117216.7831611125 | -0.13536993683531 | 0.0378358552801036 | 0.137686548501649 |
| P19174 | P19174 | PLCG1_HUMAN | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1) | PLCG1 | calcium-mediated signaling [GO:0019722]; cell migration [GO:0016477]; cellular response to epidermal growth factor stimulus [GO:0071364]; epidermal growth factor receptor signaling pathway [GO:0007173]; Fc-epsilon receptor signaling pathway [GO:0038095]; in utero embryonic development [GO:0001701]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipid catabolic process [GO:0009395]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; release of sequestered calcium ion into cytosol [GO:0051209]; T cell receptor signaling pathway [GO:0050852] | cell projection [GO:0042995]; cell-cell junction [GO:0005911]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; Schaffer collateral - CA1 synapse [GO:0098685] | calcium ion binding [GO:0005509]; calcium-dependent phospholipase C activity [GO:0050429]; glutamate receptor binding [GO:0035254]; guanyl-nucleotide exchange factor activity [GO:0005085]; neurotrophin TRKA receptor binding [GO:0005168]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]; protein kinase binding [GO:0019901]; receptor tyrosine kinase binding [GO:0030971] | 9214.62250015502 | -0.441718107951285 | 0.0378062278170585 | 0.137686548501649 |
| Q9H2C0 | Q9H2C0 | GAN_HUMAN | Gigaxonin (Kelch-like protein 16) | GAN | cytoskeleton organization [GO:0007010]; protein ubiquitination [GO:0016567] | Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829] | 5871.74314381673 | -0.335372022648097 | 0.0383897498695493 | 0.139612530655242 | |
| P15531 | P15531 | NDKA_HUMAN | Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein) | NME1 | cell differentiation [GO:0030154]; CTP biosynthetic process [GO:0006241]; endocytosis [GO:0006897]; GTP biosynthetic process [GO:0006183]; lactation [GO:0007595]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; phosphorylation [GO:0016310]; positive regulation of DNA binding [GO:0043388]; positive regulation of epithelial cell proliferation [GO:0050679]; regulation of apoptotic process [GO:0042981]; UTP biosynthetic process [GO:0006228] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; ruffle membrane [GO:0032587] | 3'-5' exonuclease activity [GO:0008408]; ATP binding [GO:0005524]; DNA nuclease activity [GO:0004536]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleoside diphosphate kinase activity [GO:0004550]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723] | 112515.250775476 | -0.168715504686856 | 0.0385972861073946 | 0.140277243800191 |
| Q99442 | Q99442 | SEC62_HUMAN | Translocation protein SEC62 (Translocation protein 1) (TP-1) (hTP-1) | SEC62 | cotranslational protein targeting to membrane [GO:0006613]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; post-translational protein targeting to membrane, translocation [GO:0031204] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; rough endoplasmic reticulum [GO:0005791] | signaling receptor activity [GO:0038023] | 69556.19660571824 | 0.244296627787734 | 0.0387828252033796 | 0.140861210001506 |
| P11233 | P11233 | RALA_HUMAN | Ras-related protein Ral-A (EC 3.6.5.2) | RALA | cell cycle [GO:0007049]; cell division [GO:0051301]; chemotaxis [GO:0006935]; establishment of protein localization to mitochondrion [GO:0072655]; exocytosis [GO:0006887]; membrane raft localization [GO:0051665]; neural tube closure [GO:0001843]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of mitochondrial fission [GO:0090141]; Ras protein signal transduction [GO:0007265]; receptor internalization [GO:0031623]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of exocytosis [GO:0017157]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; signal transduction [GO:0007165] | cell surface [GO:0009986]; cleavage furrow [GO:0032154]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic membrane [GO:0097060] | ATPase binding [GO:0051117]; Edg-2 lysophosphatidic acid receptor binding [GO:0031755]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin binding [GO:0017022]; ubiquitin protein ligase binding [GO:0031625] | 782776.2615247755 | -0.326385394978854 | 0.0388431023495137 | 0.14098976163507 |
| Q8N6T3 | Q8N6T3 | ARFG1_HUMAN | ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) | ARFGAP1 | protein transport [GO:0015031]; regulation of ARF protein signal transduction [GO:0032012]; regulation of endocytosis [GO:0030100]; vesicle-mediated transport [GO:0016192] | cytosol [GO:0005829]; Golgi membrane [GO:0000139]; synapse [GO:0045202] | GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] | 45437.35465677025 | 0.178024990631796 | 0.0390131475870067 | 0.141516321528797 |
| Q9Y244 | Q9Y244 | POMP_HUMAN | Proteasome maturation protein (Proteassemblin) (Protein UMP1 homolog) (hUMP1) (Voltage-gated K channel beta subunit 4.1) | POMP | proteasome assembly [GO:0043248] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleus [GO:0005634] | 3588.812209132525 | -0.870204215773585 | 0.0392610179897738 | 0.142324330089609 | |
| Q8NB37 | Q8NB37 | GALD1_HUMAN | Glutamine amidotransferase-like class 1 domain-containing protein 1 (Ferry endosomal RAB5 effector complex subunit 5) (Fy-5) (Parkinson disease 7 domain-containing protein 1) | GATD1 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243] | cytoplasm [GO:0005737]; extracellular exosome [GO:0070062] | glyoxalase III activity [GO:0019172] | 7329.2288378851645 | -0.532932473868239 | 0.0394108234257111 | 0.142776039341483 |
| P11498 | P11498 | PYC_HUMAN | Pyruvate carboxylase, mitochondrial (EC 6.4.1.1) (Pyruvic carboxylase) (PCB) | PC | gluconeogenesis [GO:0006094]; lipid metabolic process [GO:0006629]; NADH metabolic process [GO:0006734]; NADP metabolic process [GO:0006739]; negative regulation of gene expression [GO:0010629]; positive regulation by host of viral process [GO:0044794]; pyruvate metabolic process [GO:0006090]; viral release from host cell [GO:0019076]; viral RNA genome packaging [GO:0019074] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] | ATP binding [GO:0005524]; biotin binding [GO:0009374]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; pyruvate carboxylase activity [GO:0004736] | 7543.40326089321 | 0.265843476563907 | 0.0398035929995402 | 0.144106810182361 |
| Q01130 | Q01130 | SRSF2_HUMAN | Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2) | SRSF2 | mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; response to vitamin E [GO:0033197]; RNA splicing [GO:0008380] | cytosol [GO:0005829]; interchromatin granule [GO:0035061]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726]; spliceosomal complex [GO:0005681] | pre-mRNA binding [GO:0036002]; protein kinase C binding [GO:0005080]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714] | 22284.3023420816 | 0.526798072732333 | 0.0398641703516837 | 0.144233965014457 |
| Q9NZC3 | Q9NZC3 | GDE1_HUMAN | Glycerophosphodiester phosphodiesterase 1 (Glycerophosphoinositol glycerophosphodiesterase GDE1) (EC 3.1.4.44) (Lysophospholipase D GDE1) (EC 3.1.4.-) (Membrane-interacting protein of RGS16) (RGS16-interacting membrane protein) | GDE1 | ethanolamine metabolic process [GO:0006580]; glycerophospholipid catabolic process [GO:0046475]; lipid metabolic process [GO:0006629]; N-acylethanolamine metabolic process [GO:0070291]; phospholipid metabolic process [GO:0006644] | cytoplasmic vesicle membrane [GO:0030659]; membrane [GO:0016020]; plasma membrane [GO:0005886] | glycerophosphodiester phosphodiesterase activity [GO:0008889]; glycerophosphoinositol glycerophosphodiesterase activity [GO:0047395]; lysophospholipase activity [GO:0004622]; metal ion binding [GO:0046872] | 11226.80415409965 | -0.347422693553417 | 0.0400378926854411 | 0.144770070169565 |
| Q9Y547 | Q9Y547 | IFT25_HUMAN | Intraflagellar transport protein 25 homolog (Heat shock protein beta-11) (Hspb11) (Heat shock protein family B member 11) (Placental protein 25) (PP25) | IFT25 | cell differentiation [GO:0030154]; cilium assembly [GO:0060271]; heart development [GO:0007507]; intraciliary anterograde transport [GO:0035720]; kidney development [GO:0001822]; left/right axis specification [GO:0070986]; lung development [GO:0030324]; protein transport [GO:0015031]; skeletal system development [GO:0001501]; smoothened signaling pathway [GO:0007224]; spermatogenesis [GO:0007283] | centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; intraciliary transport particle B [GO:0030992] | metal ion binding [GO:0046872] | 28213.10215551855 | 0.302547705332353 | 0.0407976501342328 | 0.14732918142802 |
| Q6NUK4 | Q6NUK4 | REEP3_HUMAN | Receptor expression-enhancing protein 3 | REEP3 | cell division [GO:0051301]; endoplasmic reticulum tubular network organization [GO:0071786]; mitotic nuclear membrane reassembly [GO:0007084]; nuclear envelope organization [GO:0006998] | cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782] | microtubule binding [GO:0008017] | 11951.55094575015 | 0.287322257423891 | 0.0413399163494518 | 0.149192335054773 |
| P29373 | P29373 | RABP2_HUMAN | Cellular retinoic acid-binding protein 2 (Cellular retinoic acid-binding protein II) (CRABP-II) | CRABP2 | embryonic forelimb morphogenesis [GO:0035115]; epidermis development [GO:0008544]; fatty acid transport [GO:0015908]; positive regulation of collateral sprouting [GO:0048672]; regulation of DNA-templated transcription [GO:0006355]; retinoic acid metabolic process [GO:0042573]; signal transduction [GO:0007165] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | cyclin binding [GO:0030332]; fatty acid binding [GO:0005504]; retinal binding [GO:0016918]; retinoic acid binding [GO:0001972]; retinoid binding [GO:0005501]; retinol binding [GO:0019841] | 41387.4055314322 | -0.226600131931425 | 0.0414696330724763 | 0.149565207503915 |
| Q9UHE8 | Q9UHE8 | STEA1_HUMAN | STEAP1 protein (Six-transmembrane epithelial antigen of prostate 1) | STEAP1 | cell-cell junction [GO:0005911]; endosome [GO:0005768]; endosome membrane [GO:0010008]; membrane [GO:0016020]; plasma membrane [GO:0005886] | heme binding [GO:0020037]; metal ion binding [GO:0046872] | 12221.655676813 | -0.38256518284766 | 0.0415786792321246 | 0.149767829961359 | |
| Q13158 | Q13158 | FADD_HUMAN | FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity) | FADD | activation of cysteine-type endopeptidase activity [GO:0097202]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; behavioral response to cocaine [GO:0048148]; cellular response to mechanical stimulus [GO:0071260]; death-inducing signaling complex assembly [GO:0071550]; defense response to virus [GO:0051607]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; innate immune response [GO:0045087]; kidney development [GO:0001822]; lymph node development [GO:0048535]; motor neuron apoptotic process [GO:0097049]; necroptotic signaling pathway [GO:0097527]; negative regulation of activation-induced cell death of T cells [GO:0070236]; negative regulation of necroptotic process [GO:0060546]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation [GO:2000454]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of innate immune response [GO:0045089]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of proteolysis [GO:0045862]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; positive regulation of type II interferon production [GO:0032729]; spleen development [GO:0048536]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538]; TRAIL-activated apoptotic signaling pathway [GO:0036462] | CD95 death-inducing signaling complex [GO:0031265]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; plasma membrane [GO:0005886]; ripoptosome [GO:0097342] | caspase binding [GO:0089720]; death effector domain binding [GO:0035877]; death receptor binding [GO:0005123]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; protease binding [GO:0002020]; protein-containing complex binding [GO:0044877]; receptor serine/threonine kinase binding [GO:0033612]; signaling adaptor activity [GO:0035591]; tumor necrosis factor receptor binding [GO:0005164]; tumor necrosis factor receptor superfamily binding [GO:0032813] | 12037.1279953396 | 0.7696485173593 | 0.0419256369557615 | 0.150921638495136 |
| P60604 | P60604 | UB2G2_HUMAN | Ubiquitin-conjugating enzyme E2 G2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme G2) (Ubiquitin carrier protein G2) (Ubiquitin-protein ligase G2) | UBE2G2 | cellular response to interferon-beta [GO:0035458]; ERAD pathway [GO:0036503]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein K48-linked ubiquitination [GO:0070936]; ubiquitin-dependent protein catabolic process [GO:0006511] | cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811] | ATP binding [GO:0005524]; identical protein binding [GO:0042802]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842] | 14418.73286590875 | 0.323588614206363 | 0.0420029782862201 | 0.151104047599824 |
| Q15118 | Q15118 | PDK1_HUMAN | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1) | PDK1 | cell population proliferation [GO:0008283]; glucose metabolic process [GO:0006006]; hypoxia-inducible factor-1alpha signaling pathway [GO:0097411]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; phosphorylation [GO:0016310]; regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0010510]; regulation of glucose metabolic process [GO:0010906] | mitochondrial matrix [GO:0005759]; mitochondrial pyruvate dehydrogenase complex [GO:0005967]; mitochondrion [GO:0005739] | ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; pyruvate dehydrogenase (acetyl-transferring) kinase activity [GO:0004740] | 9173.272487965894 | 0.220185067472364 | 0.0420686958385448 | 0.151244435673347 |
| O15484 | O15484 | CAN5_HUMAN | Calpain-5 (EC 3.4.22.-) (Calpain htra-3) (New calpain 3) (nCL-3) | CAPN5 | proteolysis [GO:0006508]; signal transduction [GO:0007165] | cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; synapse [GO:0045202] | calcium-dependent cysteine-type endopeptidase activity [GO:0004198] | 4351.20631022642 | 0.471011470685995 | 0.0421640075112804 | 0.151490974355685 |
| P21589 | P21589 | 5NTD_HUMAN | 5'-nucleotidase (5'-NT) (EC 3.1.3.35) (EC 3.1.3.5) (EC 3.1.3.89) (EC 3.1.3.91) (EC 3.1.3.99) (5'-deoxynucleotidase) (Ecto-5'-nucleotidase) (IMP-specific 5'-nucleotidase) (Thymidylate 5'-phosphatase) (CD antigen CD73) | NT5E | adenosine biosynthetic process [GO:0046086]; ADP catabolic process [GO:0046032]; AMP catabolic process [GO:0006196]; ATP metabolic process [GO:0046034]; calcium ion homeostasis [GO:0055074]; DNA metabolic process [GO:0006259]; inhibition of non-skeletal tissue mineralization [GO:0140928]; leukocyte cell-cell adhesion [GO:0007159]; negative regulation of inflammatory response [GO:0050728]; response to ATP [GO:0033198]; response to inorganic substance [GO:0010035] | cell surface [GO:0009986]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] | 5'-deoxynucleotidase activity [GO:0002953]; 5'-nucleotidase activity [GO:0008253]; GMP 5'-nucleotidase activity [GO:0050484]; identical protein binding [GO:0042802]; IMP 5'-nucleotidase activity [GO:0050483]; nucleotide binding [GO:0000166]; thymidylate 5'-phosphatase activity [GO:0050340]; XMP 5'-nucleosidase activity [GO:0106411]; zinc ion binding [GO:0008270] | 126919.9554672995 | 0.206082639255495 | 0.0422157315303545 | 0.151497861834668 |
| Q8WVJ2 | Q8WVJ2 | NUDC2_HUMAN | NudC domain-containing protein 2 | NUDCD2 | protein folding [GO:0006457] | centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; spindle pole [GO:0000922] | unfolded protein binding [GO:0051082] | 54117.065796049545 | 0.269612495176011 | 0.0423311627268196 | 0.151802764563392 |
| O14920 | O14920 | IKKB_HUMAN | Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) | IKBKB | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to tumor necrosis factor [GO:0071356]; cortical actin cytoskeleton organization [GO:0030866]; Fc-epsilon receptor signaling pathway [GO:0038095]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of bicellular tight junction assembly [GO:1903347]; negative regulation of myosin-light-chain-phosphatase activity [GO:0035509]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; protein maturation [GO:0051604]; protein phosphorylation [GO:0006468]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of phosphorylation [GO:0042325]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to virus [GO:0009615]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; stress-activated MAPK cascade [GO:0051403]; T cell receptor signaling pathway [GO:0050852]; toll-like receptor 3 signaling pathway [GO:0034138]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; tumor necrosis factor-mediated signaling pathway [GO:0033209] | CD40 receptor complex [GO:0035631]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; IkappaB kinase complex [GO:0008385]; membrane raft [GO:0045121]; nucleus [GO:0005634] | ATP binding [GO:0005524]; identical protein binding [GO:0042802]; IkappaB kinase activity [GO:0008384]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; scaffold protein binding [GO:0097110]; transferrin receptor binding [GO:1990459] | 8720.394808057816 | 0.351584447126712 | 0.0425338078220683 | 0.1524329886906 |
| P00736 | P00736 | C1R_HUMAN | Complement C1r subcomponent (EC 3.4.21.41) (Complement component 1 subcomponent r) [Cleaved into: Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain] | C1R | complement activation, classical pathway [GO:0006958]; immune response [GO:0006955]; innate immune response [GO:0045087]; zymogen activation [GO:0031638] | blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] | calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; molecular sequestering activity [GO:0140313]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] | 5711.291219796725 | -0.735161478554224 | 0.0427569102766603 | 0.153015840970315 |
| P16333 | P16333 | NCK1_HUMAN | SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha) | NCK1 | actin filament organization [GO:0007015]; antiviral innate immune response [GO:0140374]; cell migration [GO:0016477]; ephrin receptor signaling pathway [GO:0048013]; lamellipodium assembly [GO:0030032]; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:1903912]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cap-dependent translational initiation [GO:1903676]; positive regulation of cap-independent translational initiation [GO:1903679]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-serine dephosphorylation [GO:1902310]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation in response to endoplasmic reticulum stress [GO:0036493]; regulation of cell migration [GO:0030334]; response to endoplasmic reticulum stress [GO:0034976]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165]; substrate-dependent cell migration, cell extension [GO:0006930]; T cell activation [GO:0042110] | cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein phosphatase type 1 complex [GO:0000164]; ribosome [GO:0005840]; vesicle membrane [GO:0012506] | cadherin binding [GO:0045296]; cytoskeletal anchor activity [GO:0008093]; ephrin receptor binding [GO:0046875]; eukaryotic initiation factor eIF2 binding [GO:0071074]; molecular condensate scaffold activity [GO:0140693]; protein domain specific binding [GO:0019904]; protein kinase inhibitor activity [GO:0004860]; protein-macromolecule adaptor activity [GO:0030674]; receptor tyrosine kinase binding [GO:0030971]; signaling adaptor activity [GO:0035591]; signaling receptor binding [GO:0005102]; signaling receptor complex adaptor activity [GO:0030159] | 12970.76861333745 | 0.189666140547346 | 0.0427569975387079 | 0.153015840970315 |
| P25398 | P25398 | RS12_HUMAN | Small ribosomal subunit protein eS12 (40S ribosomal protein S12) | RPS12 | cytoplasmic translation [GO:0002181]; maintenance of translational fidelity [GO:1990145]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 88989.8775495068 | 0.424850626072561 | 0.042804466632183 | 0.153015840970315 |
| O43765 | O43765 | SGTA_HUMAN | Small glutamine-rich tetratricopeptide repeat-containing protein alpha (Alpha-SGT) (Vpu-binding protein) (UBP) | SGTA | ERAD pathway [GO:0036503]; negative regulation of ERAD pathway [GO:1904293]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; tail-anchored membrane protein insertion into ER membrane [GO:0071816] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; TRC complex [GO:0072380] | BAT3 complex binding [GO:1904288]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; protein self-association [GO:0043621] | 59171.31246012125 | 0.267440913957545 | 0.0427940251050857 | 0.153015840970315 |
| Q969T3 | Q969T3 | SNX21_HUMAN | Sorting nexin-21 (Sorting nexin L) (SNX-L) | SNX21 | protein transport [GO:0015031] | early endosome membrane [GO:0031901] | phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546] | 2581.14442135571 | 0.309214049568587 | 0.0428568200608406 | 0.153106394996673 |
| Q16512 | Q16512 | PKN1_HUMAN | Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N) | PKN1 | B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; epithelial cell migration [GO:0010631]; hyperosmotic response [GO:0006972]; intracellular signal transduction [GO:0035556]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of protein phosphorylation [GO:0001933]; post-translational protein modification [GO:0043687]; protein phosphorylation [GO:0006468]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of cell motility [GO:2000145]; regulation of germinal center formation [GO:0002634]; regulation of immunoglobulin production [GO:0002637]; regulation of transcription by RNA polymerase II [GO:0006357]; renal system process [GO:0003014]; signal transduction [GO:0007165]; spleen development [GO:0048536] | cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] | ATP binding [GO:0005524]; chromatin binding [GO:0003682]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; histone H3T11 kinase activity [GO:0035402]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor coactivator activity [GO:0030374]; protein kinase activity [GO:0004672]; protein kinase C binding [GO:0005080]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267] | 12486.18249083365 | -0.222442410485745 | 0.0429846671880481 | 0.153466366910826 |
| Q92538 | Q92538 | GBF1_HUMAN | Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1) | GBF1 | cell activation involved in immune response [GO:0002263]; cellular response to virus [GO:0098586]; cilium assembly [GO:0060271]; COPI coating of Golgi vesicle [GO:0048205]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endoplasmic reticulum-Golgi intermediate compartment organization [GO:0097111]; establishment of monopolar cell polarity [GO:0061162]; Golgi disassembly [GO:0090166]; Golgi organization [GO:0007030]; Golgi to endosome transport [GO:0006895]; neutrophil chemotaxis [GO:0030593]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein localization to endoplasmic reticulum tubular network [GO:1903420]; protein localization to Golgi apparatus [GO:0034067]; protein transport [GO:0015031]; reactive oxygen species biosynthetic process [GO:1903409]; regulation of ARF protein signal transduction [GO:0032012]; regulation of mitotic cell cycle [GO:0007346]; regulation of protein localization to cell surface [GO:2000008]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890] | cell leading edge [GO:0031252]; cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lipid droplet [GO:0005811]; membrane [GO:0016020]; trans-Golgi network [GO:0005802] | guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025] | 15737.6063500534 | -0.215368900549642 | 0.0431653180378575 | 0.153917364381687 |
| P35555 | P35555 | FBN1_HUMAN | Fibrillin-1 [Cleaved into: Asprosin] | FBN1 | anatomical structure morphogenesis [GO:0009653]; camera-type eye development [GO:0043010]; cell adhesion mediated by integrin [GO:0033627]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to transforming growth factor beta stimulus [GO:0071560]; embryonic eye morphogenesis [GO:0048048]; gene expression [GO:0010467]; heart development [GO:0007507]; lung alveolus development [GO:0048286]; metanephros development [GO:0001656]; negative regulation of osteoclast development [GO:2001205]; negative regulation of osteoclast differentiation [GO:0045671]; post-embryonic eye morphogenesis [GO:0048050]; sequestering of BMP in extracellular matrix [GO:0035582]; sequestering of TGFbeta in extracellular matrix [GO:0035583]; skeletal system development [GO:0001501] | basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; microfibril [GO:0001527] | calcium ion binding [GO:0005509]; extracellular matrix constituent conferring elasticity [GO:0030023]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; protein-containing complex binding [GO:0044877] | 23139.79414903205 | 0.183654462019281 | 0.0432689606064199 | 0.154189893582374 |
| Q13243 | Q13243 | SRSF5_HUMAN | Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5) | SRSF5 | mRNA processing [GO:0006397]; mRNA splice site recognition [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398] | cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] | mRNA binding [GO:0003729]; RNA binding [GO:0003723] | 21137.00720037125 | 0.358790401878305 | 0.043569259391068 | 0.155162428478813 |
| P62491 | P62491 | RB11A_HUMAN | Ras-related protein Rab-11A (Rab-11) (EC 3.6.5.2) (YL8) | RAB11A | amyloid-beta clearance by transcytosis [GO:0150093]; astral microtubule organization [GO:0030953]; early endosome to recycling endosome transport [GO:0061502]; establishment of protein localization to membrane [GO:0090150]; establishment of protein localization to organelle [GO:0072594]; establishment of vesicle localization [GO:0051650]; exocytosis [GO:0006887]; exosomal secretion [GO:1990182]; Golgi to plasma membrane protein transport [GO:0043001]; melanosome transport [GO:0032402]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle assembly [GO:0090307]; multivesicular body assembly [GO:0036258]; neuron projection development [GO:0031175]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; plasma membrane to endosome transport [GO:0048227]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of mitotic cytokinetic process [GO:1903438]; protein localization to cell surface [GO:0034394]; protein localization to cilium [GO:0061512]; protein localization to plasma membrane [GO:0072659]; protein transmembrane transport [GO:0071806]; regulation of cilium assembly [GO:1902017]; regulation of cytokinesis [GO:0032465]; regulation of early endosome to recycling endosome transport [GO:1902954]; regulation of endocytic recycling [GO:2001135]; regulation of multivesicular body size [GO:0010796]; regulation of protein localization to centrosome [GO:1904779]; regulation of vesicle-mediated transport [GO:0060627]; vesicle-mediated transport [GO:0016192] | centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; multivesicular body [GO:0005771]; phagocytic vesicle [GO:0045335]; postsynaptic recycling endosome [GO:0098837]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; spindle pole [GO:0000922]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133]; vesicle [GO:0031982] | dynein light intermediate chain binding [GO:0051959]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017]; myosin V binding [GO:0031489]; syntaxin binding [GO:0019905] | 152851.3592457155 | 0.260377965337799 | 0.0438109816601927 | 0.155925265129806 |
| Q9NX63 | Q9NX63 | MIC19_HUMAN | MICOS complex subunit MIC19 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 3) | CHCHD3 | cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial fusion [GO:0008053] | extracellular exosome [GO:0070062]; MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; SAM complex [GO:0001401] | molecular adaptor activity [GO:0060090]; phosphatase binding [GO:0019902] | 38245.97941257875 | 0.254319277657618 | 0.0439126991989396 | 0.156189173673065 |
| O95476 | O95476 | CNEP1_HUMAN | CTD nuclear envelope phosphatase 1 (EC 3.1.3.16) (Serine/threonine-protein phosphatase dullard) | CTDNEP1 | canonical Wnt signaling pathway [GO:0060070]; gamete generation [GO:0007276]; mesoderm development [GO:0007498]; mitotic nuclear membrane disassembly [GO:0007077]; nuclear envelope organization [GO:0006998]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of triglyceride biosynthetic process [GO:0010867]; protein dephosphorylation [GO:0006470]; protein localization to nucleus [GO:0034504] | cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; Nem1-Spo7 phosphatase complex [GO:0071595]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965] | myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722] | 10651.6649096511 | -0.261569953203338 | 0.044115395423385 | 0.156713373334733 |
| P36969 | P36969 | GPX4_HUMAN | Phospholipid hydroperoxide glutathione peroxidase GPX4 (PHGPx) (EC 1.11.1.12) (Glutathione peroxidase 4) (GPx-4) (GSHPx-4) (EC 1.11.1.9) | GPX4 | arachidonic acid metabolic process [GO:0019369]; cellular response to oxidative stress [GO:0034599]; chromatin organization [GO:0006325]; lipoxygenase pathway [GO:0019372]; long-chain fatty acid biosynthetic process [GO:0042759]; negative regulation of ferroptosis [GO:0110076]; phospholipid metabolic process [GO:0006644]; protein polymerization [GO:0051258]; response to estradiol [GO:0032355]; response to oxidative stress [GO:0006979]; spermatogenesis [GO:0007283] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] | glutathione peroxidase activity [GO:0004602]; identical protein binding [GO:0042802]; phospholipid-hydroperoxide glutathione peroxidase activity [GO:0047066]; selenium binding [GO:0008430] | 26915.7584879696 | 0.216545892243401 | 0.0440975228220499 | 0.156713373334733 |
| P55268 | P55268 | LAMB2_HUMAN | Laminin subunit beta-2 (Laminin B1s chain) (Laminin-11 subunit beta) (Laminin-14 subunit beta) (Laminin-15 subunit beta) (Laminin-3 subunit beta) (Laminin-4 subunit beta) (Laminin-7 subunit beta) (Laminin-9 subunit beta) (S-laminin subunit beta) (S-LAM beta) | LAMB2 | animal organ morphogenesis [GO:0009887]; astrocyte development [GO:0014002]; axon extension involved in regeneration [GO:0048677]; axon guidance [GO:0007411]; metanephric glomerular basement membrane development [GO:0072274]; metanephric podocyte development [GO:0072249]; neuromuscular junction development [GO:0007528]; positive regulation of cell adhesion [GO:0045785]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; regulation of basement membrane organization [GO:0110011]; retina development in camera-type eye [GO:0060041]; Schwann cell development [GO:0014044]; substrate adhesion-dependent cell spreading [GO:0034446]; visual perception [GO:0007601] | basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; laminin-11 complex [GO:0043260]; laminin-3 complex [GO:0005608]; neuromuscular junction [GO:0031594]; protein complex involved in cell-matrix adhesion [GO:0098637]; synaptic cleft [GO:0043083] | extracellular matrix structural constituent [GO:0005201]; integrin binding [GO:0005178]; structural constituent of synapse-associated extracellular matrix [GO:0150043]; structural molecule activity [GO:0005198] | 24007.148172628848 | 0.153399747011949 | 0.0443017505929463 | 0.157276766202778 |
| Q9UBB6 | Q9UBB6 | NCDN_HUMAN | Neurochondrin | NCDN | bone resorption [GO:0045453]; neuron projection development [GO:0031175]; regulation of neuronal synaptic plasticity [GO:0048168] | cytosol [GO:0005829]; dendrite [GO:0030425]; endosome membrane [GO:0010008]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; postsynapse [GO:0098794] | 10932.345367619251 | -0.3895561723395 | 0.0443430981251751 | 0.157324980574353 | |
| Q9H9A6 | Q9H9A6 | LRC40_HUMAN | Leucine-rich repeat-containing protein 40 | LRRC40 | signal transduction [GO:0007165] | membrane [GO:0016020] | 14915.957585213699 | -0.317773834884918 | 0.0444011036276178 | 0.157432198469388 | |
| Q9Y3I1 | Q9Y3I1 | FBX7_HUMAN | F-box only protein 7 | FBXO7 | autophagy of mitochondrion [GO:0000422]; lymphocyte differentiation [GO:0030098]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of lymphocyte differentiation [GO:0045620]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; positive regulation of autophagy of mitochondrion [GO:1903599]; positive regulation of mitophagy [GO:1901526]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein targeting to mitochondrion [GO:0006626]; protein ubiquitination [GO:0016567]; regulation of locomotion [GO:0040012]; regulation of neuron projection development [GO:0010975]; regulation of protein stability [GO:0031647]; ubiquitin-dependent protein catabolic process [GO:0006511] | classical Lewy body [GO:0097414]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glial cytoplasmic inclusion [GO:0097409]; Lewy body core [GO:1990037]; Lewy body corona [GO:1990038]; Lewy neurite [GO:0097462]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151] | protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; ubiquitin binding [GO:0043130]; ubiquitin ligase-substrate adaptor activity [GO:1990756]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842] | 6429.093521756375 | 0.338422083785302 | 0.0444460133168443 | 0.157492877706842 |
| P62241 | P62241 | RS8_HUMAN | Small ribosomal subunit protein eS8 (40S ribosomal protein S8) | RPS8 | cytoplasmic translation [GO:0002181]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; small-subunit processome [GO:0032040] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 380991.528019201 | 0.186297578230792 | 0.0445486316175547 | 0.157659304650259 |
| Q16637 | Q16637 | SMN_HUMAN | Survival motor neuron protein (Component of gems 1) (Gemin-1) | SMN1; SMN2 | DNA-templated transcription termination [GO:0006353]; nervous system development [GO:0007399]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387] | axon [GO:0030424]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; neuron projection [GO:0043005]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]; Z disc [GO:0030018] | identical protein binding [GO:0042802]; RNA binding [GO:0003723] | 9528.27655708667 | 0.304541059289208 | 0.0445775304123709 | 0.157663100696937 |
| P17096 | P17096 | HMGA1_HUMAN | High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1) (High mobility group protein R) | HMGA1 | base-excision repair [GO:0006284]; DNA unwinding involved in DNA replication [GO:0006268]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; nucleosome disassembly [GO:0006337]; oncogene-induced cell senescence [GO:0090402]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355] | cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; senescence-associated heterochromatin focus [GO:0035985]; transcription regulator complex [GO:0005667] | 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; enzyme binding [GO:0019899]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; molecular adaptor activity [GO:0060090]; molecular function activator activity [GO:0140677]; nuclear receptor coactivator activity [GO:0030374]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear retinoid X receptor binding [GO:0046965]; peroxisome proliferator activated receptor binding [GO:0042975]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; structural constituent of chromatin [GO:0030527]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription coregulator binding [GO:0001221] | 463254.2774552905 | 0.706536614428783 | 0.0446950401682038 | 0.157980098311318 |
| Q8WWI5 | Q8WWI5 | CTL1_HUMAN | Choline transporter-like protein 1 (CDw92) (Solute carrier family 44 member 1) (CD antigen CD92) | SLC44A1 | choline catabolic process [GO:0042426]; choline transport [GO:0015871]; ethanolamine transport [GO:0034229]; phosphatidylcholine biosynthetic process [GO:0006656]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] | antiporter activity [GO:0015297]; choline transmembrane transporter activity [GO:0015220]; ethanolamine transmembrane transporter activity [GO:0034228] | 7432.41585052618 | -1.17309808943574 | 0.0449933764611456 | 0.158935455753648 |
| P22304 | P22304 | IDS_HUMAN | Iduronate 2-sulfatase (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase) (Idursulfase) [Cleaved into: Iduronate 2-sulfatase 42 kDa chain; Iduronate 2-sulfatase 14 kDa chain] | IDS | dermatan sulfate catabolic process [GO:0030209]; glycosaminoglycan catabolic process [GO:0006027]; heparan sulfate proteoglycan catabolic process [GO:0030200] | cytoplasm [GO:0005737]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764] | calcium ion binding [GO:0005509]; iduronate-2-sulfatase activity [GO:0004423] | 12880.441558665501 | 0.161052901997795 | 0.0452133392352749 | 0.159612947107207 |
| P04406 | P04406 | G3P_HUMAN | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | GAPDH | antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to type II interferon [GO:0071346]; defense response to fungus [GO:0050832]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; killing by host of symbiont cells [GO:0051873]; killing of cells of another organism [GO:0031640]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of translation [GO:0017148]; neuron apoptotic process [GO:0051402]; peptidyl-cysteine S-trans-nitrosylation [GO:0035606]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production [GO:0001819]; positive regulation of type I interferon production [GO:0032481]; protein stabilization [GO:0050821]; regulation of macroautophagy [GO:0016241] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; GAIT complex [GO:0097452]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; vesicle [GO:0031982] | aspartic-type endopeptidase inhibitor activity [GO:0019828]; disordered domain specific binding [GO:0097718]; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [GO:0004365]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; peptidyl-cysteine S-nitrosylase activity [GO:0035605] | 451847.4083417705 | 0.234069649816138 | 0.0452421575088648 | 0.15961523315394 |
| Q969X5 | Q969X5 | ERGI1_HUMAN | Endoplasmic reticulum-Golgi intermediate compartment protein 1 (ER-Golgi intermediate compartment 32 kDa protein) (ERGIC-32) | ERGIC1 | endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890] | COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654] | 215425.0171365075 | 0.186271628420278 | 0.0452808683198893 | 0.159652395706592 | |
| Q9BQQ3 | Q9BQQ3 | GORS1_HUMAN | Golgi reassembly-stacking protein 1 (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5) (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) | GORASP1 | establishment of protein localization to plasma membrane [GO:0061951]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; negative regulation of dendrite morphogenesis [GO:0050774]; protein N-linked glycosylation [GO:0006487]; protein transport [GO:0015031] | cis-Golgi network [GO:0005801]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] | metal ion binding [GO:0046872] | 22421.3225283433 | -0.470204035702839 | 0.0453977656687554 | 0.159965012611423 |
| Q9NT62 | Q9NT62 | ATG3_HUMAN | Ubiquitin-like-conjugating enzyme ATG3 (EC 2.3.2.-) (Autophagy-related protein 3) (APG3-like) (hApg3) (Protein PC3-96) | ATG3 | autophagosome assembly [GO:0000045]; glycophagy [GO:0061723]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; negative regulation of phagocytosis [GO:0050765]; nucleophagy [GO:0044804]; protein targeting to membrane [GO:0006612]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]; regulation of cilium assembly [GO:1902017] | Atg12-Atg5-Atg16 complex [GO:0034274]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; phagophore assembly site [GO:0000407] | Atg12 transferase activity [GO:0019777]; Atg8-family conjugating enzyme activity [GO:0141046]; Atg8-family ligase activity [GO:0019776]; enzyme binding [GO:0019899]; ubiquitin-like protein transferase activity [GO:0019787] | 28830.56046673395 | 0.157540976498585 | 0.0457085960082598 | 0.160960164687881 |
| P39687 | P39687 | AN32A_HUMAN | Acidic leucine-rich nuclear phosphoprotein 32 family member A (Acidic nuclear phosphoprotein pp32) (pp32) (Leucine-rich acidic nuclear protein) (LANP) (Mapmodulin) (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Putative HLA-DR-associated protein I) (PHAPI) | ANP32A | intracellular signal transduction [GO:0035556]; nucleocytoplasmic transport [GO:0006913]; regulation of apoptotic process [GO:0042981] | cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] | histone binding [GO:0042393]; RNA binding [GO:0003723] | 45426.924568198854 | 0.318802743064647 | 0.0457401750108783 | 0.160971323982383 |
| Q6ZVK8 | Q6ZVK8 | NUD18_HUMAN | 8-oxo-dGDP phosphatase NUDT18 (EC 3.6.1.58) (2-hydroxy-dADP phosphatase) (7,8-dihydro-8-oxoguanine phosphatase) (MutT homolog 3) (Nucleoside diphosphate-linked moiety X motif 18) (Nudix motif 18) | NUDT18 | dADP catabolic process [GO:0046057]; dGDP catabolic process [GO:0046067]; GDP catabolic process [GO:0046712]; nucleobase-containing small molecule metabolic process [GO:0055086] | cytosol [GO:0005829] | 8-hydroxy-dADP phosphatase activity [GO:0044717]; 8-oxo-dGDP phosphatase activity [GO:0044715]; 8-oxo-GDP phosphatase activity [GO:0044716]; magnesium ion binding [GO:0000287] | 6223.411131637365 | -0.325623151225883 | 0.0459385045760562 | 0.16156894284788 |
| P47224 | P47224 | MSS4_HUMAN | Guanine nucleotide exchange factor MSS4 (Rab-interacting factor) | RABIF | membrane fusion [GO:0061025]; post-Golgi vesicle-mediated transport [GO:0006892]; protein transport [GO:0015031]; small GTPase-mediated signal transduction [GO:0007264] | cytosol [GO:0005829]; membrane [GO:0016020] | guanyl-nucleotide exchange factor activity [GO:0005085]; zinc ion binding [GO:0008270] | 41382.17194989315 | 0.3085375014254 | 0.0462058726809487 | 0.162408483008843 |
| P27348 | P27348 | 1433T_HUMAN | 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) | YWHAQ | negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of monoatomic ion transmembrane transport [GO:0034766]; protein targeting [GO:0006605]; signal transduction [GO:0007165]; small GTPase-mediated signal transduction [GO:0007264]; substantia nigra development [GO:0021762] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; synapse [GO:0045202] | 14-3-3 protein binding [GO:0071889]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; transmembrane transporter binding [GO:0044325] | 156674.61064648448 | 0.337084629484589 | 0.0462935304289147 | 0.162414330284973 |
| O00391 | O00391 | QSOX1_HUMAN | Sulfhydryl oxidase 1 (hQSOX) (EC 1.8.3.2) (Quiescin Q6) | QSOX1 | extracellular matrix assembly [GO:0085029]; negative regulation of macroautophagy [GO:0016242]; protein folding [GO:0006457] | endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; platelet alpha granule lumen [GO:0031093]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] | FAD binding [GO:0071949]; flavin-dependent sulfhydryl oxidase activity [GO:0016971]; protein disulfide isomerase activity [GO:0003756] | 23443.5683357993 | -0.149836487557059 | 0.0464835506927738 | 0.162980073159193 |
| Q96CT7 | Q96CT7 | CC124_HUMAN | Coiled-coil domain-containing protein 124 | CCDC124 | cell cycle [GO:0007049]; cell division [GO:0051301]; transcription by RNA polymerase II [GO:0006366] | centrosome [GO:0005813]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713] | 67681.9949616994 | 0.34860676120435 | 0.0465763354060548 | 0.163204400996108 |
| Q14118 | Q14118 | DAG1_HUMAN | Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)] | DAG1 | angiogenesis involved in wound healing [GO:0060055]; axon guidance [GO:0007411]; axon regeneration [GO:0031103]; basement membrane organization [GO:0071711]; branching involved in salivary gland morphogenesis [GO:0060445]; calcium-dependent cell-matrix adhesion [GO:0016340]; cellular response to cholesterol [GO:0071397]; cellular response to mechanical stimulus [GO:0071260]; commissural neuron axon guidance [GO:0071679]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; heart morphogenesis [GO:0003007]; membrane protein ectodomain proteolysis [GO:0006509]; microtubule anchoring [GO:0034453]; morphogenesis of an epithelial sheet [GO:0002011]; morphogenesis of an epithelium [GO:0002009]; muscle attachment [GO:0016203]; myelination in peripheral nervous system [GO:0022011]; negative regulation of cell migration [GO:0030336]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; nerve development [GO:0021675]; nerve maturation [GO:0021682]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of myelination [GO:0031643]; positive regulation of oligodendrocyte differentiation [GO:0048714]; protein transport [GO:0015031]; regulation of embryonic cell shape [GO:0016476]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gastrulation [GO:0010470]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of synapse organization [GO:0050807]; regulation of synaptic plasticity [GO:0048167]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; response to muscle activity [GO:0014850]; response to peptide hormone [GO:0043434]; retrograde trans-synaptic signaling by trans-synaptic protein complex [GO:0098942]; skeletal muscle tissue regeneration [GO:0043403] | adherens junction [GO:0005912]; basement membrane [GO:0005604]; basolateral plasma membrane [GO:0016323]; collagen-containing extracellular matrix [GO:0062023]; contractile ring [GO:0070938]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dystroglycan complex [GO:0016011]; dystrophin-associated glycoprotein complex [GO:0016010]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; membrane [GO:0016020]; node of Ranvier [GO:0033268]; nuclear periphery [GO:0034399]; nucleoplasm [GO:0005654]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic cytosol [GO:0099524]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383] | actin binding [GO:0003779]; alpha-actinin binding [GO:0051393]; calcium ion binding [GO:0005509]; dystroglycan binding [GO:0002162]; laminin binding [GO:0043236]; laminin-1 binding [GO:0043237]; protein-containing complex binding [GO:0044877]; SH2 domain binding [GO:0042169]; structural constituent of muscle [GO:0008307]; tubulin binding [GO:0015631]; vinculin binding [GO:0017166]; virus receptor activity [GO:0001618] | 18078.70789569645 | 0.309722359826789 | 0.0468072696005695 | 0.163804354993855 |
| Q86YZ3 | Q86YZ3 | HORN_HUMAN | Hornerin | HRNR | cell envelope organization [GO:0043163]; establishment of skin barrier [GO:0061436]; keratinization [GO:0031424] | azurophil granule lumen [GO:0035578]; collagen-containing extracellular matrix [GO:0062023]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; keratohyalin granule [GO:0036457]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] | calcium ion binding [GO:0005509]; transition metal ion binding [GO:0046914] | 3045.0682039242447 | -4.29777996578582 | 0.0470658381307542 | 0.164208767764072 |
| P24592 | P24592 | IBP6_HUMAN | Insulin-like growth factor-binding protein 6 (IBP-6) (IGF-binding protein 6) (IGFBP-6) | IGFBP6 | cell migration [GO:0016477]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of stress-activated MAPK cascade [GO:0032874]; regulation of insulin-like growth factor receptor signaling pathway [GO:0043567]; signal transduction [GO:0007165] | extracellular region [GO:0005576]; extracellular space [GO:0005615]; insulin-like growth factor binary complex [GO:0042568] | fibronectin binding [GO:0001968]; identical protein binding [GO:0042802]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]; signaling receptor binding [GO:0005102] | 5785.349032424415 | 2.0375149466522 | 0.0470435864367973 | 0.164208767764072 |
| Q9H0U9 | Q9H0U9 | TSYL1_HUMAN | Testis-specific Y-encoded-like protein 1 (TSPY-like protein 1) | TSPYL1 | nucleosome assembly [GO:0006334] | chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; histone binding [GO:0042393] | 3768.18024760198 | 0.399463462479371 | 0.0470489884744564 | 0.164208767764072 |
| Q9H3U5 | Q9H3U5 | MFSD1_HUMAN | Major facilitator superfamily domain-containing protein 1 (Smooth muscle cell-associated protein 4) (SMAP-4) | MFSD1 | protein localization to lysosome [GO:0061462]; protein stabilization [GO:0050821] | lysosomal membrane [GO:0005765]; lysosome [GO:0005764] | protein homodimerization activity [GO:0042803]; transmembrane transporter activity [GO:0022857] | 24385.389287091202 | -0.612456011170232 | 0.0471600593422207 | 0.164436243835706 |
| Q7RTV0 | Q7RTV0 | PHF5A_HUMAN | PHD finger-like domain-containing protein 5A (PHD finger-like domain protein 5A) (Splicing factor 3B-associated 14 kDa protein) (SF3b14b) | PHF5A | mRNA splicing, via spliceosome [GO:0000398]; positive regulation of DNA-templated transcription [GO:0045893]; stem cell differentiation [GO:0048863]; U2-type prespliceosome assembly [GO:1903241] | catalytic step 2 spliceosome [GO:0071013]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684] | DNA binding [GO:0003677]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] | 48068.146827429795 | 0.271719972741168 | 0.047440996990935 | 0.165110988298918 |
| Q12981 | Q12981 | SEC20_HUMAN | Vesicle transport protein SEC20 (BCL2/adenovirus E1B 19 kDa protein-interacting protein 1) (Transformation-related gene 8 protein) (TRG-8) | BNIP1 | apoptotic process [GO:0006915]; apoptotic process in response to mitochondrial fragmentation [GO:0140208]; endoplasmic reticulum membrane fusion [GO:0016320]; endoplasmic reticulum organization [GO:0007029]; execution phase of apoptosis [GO:0097194]; negative regulation of apoptotic process [GO:0043066]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890] | cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; nuclear envelope [GO:0005635]; SNARE complex [GO:0031201] | calcium-induced calcium release activity [GO:0048763]; SNAP receptor activity [GO:0005484] | 19838.039564075552 | -0.267191074834886 | 0.0476450675466912 | 0.165436022473491 |
| Q6P582 | Q6P582 | MZT2A_HUMAN | Mitotic-spindle organizing protein 2A (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2A) | MZT2A | centrosome [GO:0005813]; cytosol [GO:0005829]; gamma-tubulin ring complex [GO:0000931]; nucleoplasm [GO:0005654]; spindle [GO:0005819] | 6965.97831292064 | 0.512276152721561 | 0.0476511804936 | 0.165436022473491 | ||
| Q9NQS3 | Q9NQS3 | NECT3_HUMAN | Nectin-3 (CDw113) (Nectin cell adhesion molecule 3) (Poliovirus receptor-related protein 3) (CD antigen CD113) | NECTIN3 | establishment of protein localization to plasma membrane [GO:0061951]; fertilization [GO:0009566]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; lens morphogenesis in camera-type eye [GO:0002089]; protein localization to cell junction [GO:1902414]; retina morphogenesis in camera-type eye [GO:0060042]; symbiont entry into host cell [GO:0046718] | adherens junction [GO:0005912]; apical junction complex [GO:0043296]; axon [GO:0030424]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839] | cell adhesion molecule binding [GO:0050839]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] | 5948.337270258769 | 0.631351091701772 | 0.0475967766860323 | 0.165436022473491 |
| Q9Y5L0 | Q9Y5L0 | TNPO3_HUMAN | Transportin-3 (Importin-12) (Imp12) (Transportin-SR) (TRN-SR) | TNPO3 | protein import into nucleus [GO:0006606] | annulate lamellae [GO:0005642]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear envelope [GO:0005635] | identical protein binding [GO:0042802]; nuclear import signal receptor activity [GO:0061608]; small GTPase binding [GO:0031267] | 4135.40500490032 | -0.364009008271059 | 0.0476079951719192 | 0.165436022473491 |
| Q13185 | Q13185 | CBX3_HUMAN | Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) | CBX3 | chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; heterochromatin formation [GO:0031507]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; rhythmic process [GO:0048511] | chromatin [GO:0000785]; chromatin lock complex [GO:0061793]; chromosome, centromeric region [GO:0000775]; chromosome, telomeric region [GO:0000781]; condensed chromosome, centromeric region [GO:0000779]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; RNA polymerase II transcription regulator complex [GO:0090575]; site of DNA damage [GO:0090734]; spindle [GO:0005819] | chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; histone methyltransferase binding [GO:1990226]; identical protein binding [GO:0042802]; methylated histone binding [GO:0035064]; protein domain specific binding [GO:0019904]; transcription coregulator binding [GO:0001221] | 35363.0207959199 | 0.258285351516776 | 0.0477079857875173 | 0.165531811066793 |
| Q4G0F5 | Q4G0F5 | VP26B_HUMAN | Vacuolar protein sorting-associated protein 26B (Vesicle protein sorting 26B) | VPS26B | cellular response to type II interferon [GO:0071346]; intracellular protein transport [GO:0006886]; regulation of macroautophagy [GO:0016241]; retrograde transport, endosome to Golgi [GO:0042147] | cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; late endosome [GO:0005770]; phagocytic vesicle [GO:0045335]; retromer complex [GO:0030904]; retromer, cargo-selective complex [GO:0030906] | 15288.2717034618 | -0.159062778512341 | 0.047774624653216 | 0.165661580957847 | |
| Q9H0P0 | Q9H0P0 | 5NT3A_HUMAN | Cytosolic 5'-nucleotidase 3A (EC 3.1.3.5) (7-methylguanosine phosphate-specific 5'-nucleotidase) (7-methylguanosine nucleotidase) (EC 3.1.3.91) (Cytosolic 5'-nucleotidase 3) (Cytosolic 5'-nucleotidase III) (cN-III) (Pyrimidine 5'-nucleotidase 1) (P5'N-1) (P5N-1) (PN-I) (Uridine 5'-monophosphate hydrolase 1) (p36) | NT5C3A | defense response to virus [GO:0051607]; nucleotide metabolic process [GO:0009117]; pyrimidine nucleoside metabolic process [GO:0006213] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] | 5'-nucleotidase activity [GO:0008253]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166]; tRNA 2'-phosphotransferase activity [GO:0000215]; XMP 5'-nucleosidase activity [GO:0106411] | 5672.69576297626 | 0.248926642849908 | 0.0478228747407403 | 0.165727466838553 |
| Q9UP83 | Q9UP83 | COG5_HUMAN | Conserved oligomeric Golgi complex subunit 5 (COG complex subunit 5) (13S Golgi transport complex 90 kDa subunit) (GTC-90) (Component of oligomeric Golgi complex 5) (Golgi transport complex 1) | COG5 | glycosylation [GO:0070085]; Golgi organization [GO:0007030]; inter-Golgi cisterna vesicle-mediated transport [GO:0048219]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301] | cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; trans-Golgi network membrane [GO:0032588] | 8291.031871032825 | -0.387427492991712 | 0.0478773397217596 | 0.165810968703049 | |
| Q92882 | Q92882 | OSTF1_HUMAN | Osteoclast-stimulating factor 1 | OSTF1 | ossification [GO:0001503]; signal transduction [GO:0007165] | extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774] | SH3 domain binding [GO:0017124] | 27452.6512431817 | 0.206833933444909 | 0.0483669367884334 | 0.167203821746958 |
| Q8TCJ2 | Q8TCJ2 | STT3B_HUMAN | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (Oligosaccharyl transferase subunit STT3B) (STT3-B) (EC 2.4.99.18) (Source of immunodominant MHC-associated peptides homolog) | STT3B | co-translational protein modification [GO:0043686]; ERAD pathway [GO:0036503]; glycoprotein catabolic process [GO:0006516]; post-translational protein modification [GO:0043687]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; response to unfolded protein [GO:0006986] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]; oligosaccharyltransferase I complex [GO:0034998]; protein-containing complex [GO:0032991] | dolichyl-diphosphooligosaccharide-protein glycotransferase activity [GO:0004579]; metal ion binding [GO:0046872] | 44791.8756251232 | -0.185429574018169 | 0.0485774765956885 | 0.167726985003761 |
| P22570 | P22570 | ADRO_HUMAN | NADPH:adrenodoxin oxidoreductase, mitochondrial (AR) (Adrenodoxin reductase) (EC 1.18.1.6) (Ferredoxin--NADP(+) reductase) (Ferredoxin reductase) | FDXR | cholesterol metabolic process [GO:0008203]; generation of precursor metabolites and energy [GO:0006091]; steroid biosynthetic process [GO:0006694]; ubiquinone biosynthetic process [GO:0006744] | mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] | ferredoxin-NADP+ reductase activity [GO:0004324]; NADPH-adrenodoxin reductase activity [GO:0015039] | 19263.7729751987 | -0.24643858668122 | 0.0486495856431353 | 0.167873661543243 |
| P26885 | P26885 | FKBP2_HUMAN | Peptidyl-prolyl cis-trans isomerase FKBP2 (PPIase FKBP2) (EC 5.2.1.8) (13 kDa FK506-binding protein) (13 kDa FKBP) (FKBP-13) (FK506-binding protein 2) (FKBP-2) (Immunophilin FKBP13) (Rotamase) | FKBP2 | chaperone-mediated protein folding [GO:0061077] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] | FK506 binding [GO:0005528]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755] | 51251.88567482685 | 0.427220931510836 | 0.0491026136143334 | 0.169231917764287 |
| Q53EP0 | Q53EP0 | FND3B_HUMAN | Fibronectin type III domain-containing protein 3B (Factor for adipocyte differentiation 104) (HCV NS5A-binding protein 37) | FNDC3B | membrane [GO:0016020] | RNA binding [GO:0003723] | 32966.5085527899 | -0.194749420204339 | 0.0491029426058044 | 0.169231917764287 | |
| Q12965 | Q12965 | MYO1E_HUMAN | Unconventional myosin-Ie (Myosin-Ic) (Unconventional myosin 1E) | MYO1E | actin filament organization [GO:0007015]; endocytosis [GO:0006897]; glomerular basement membrane development [GO:0032836]; glomerular filtration [GO:0003094]; glomerulus development [GO:0032835]; in utero embryonic development [GO:0001701]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; podocyte development [GO:0072015]; post-embryonic hemopoiesis [GO:0035166]; vasculogenesis [GO:0001570]; vesicle transport along actin filament [GO:0030050] | actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; brush border [GO:0005903]; clathrin-coated vesicle [GO:0030136]; cuticular plate [GO:0032437]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; microvillus [GO:0005902]; myosin complex [GO:0016459]; plasma membrane [GO:0005886] | actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; phosphatidylinositol binding [GO:0035091] | 17740.75703938485 | -0.168800448719827 | 0.0494789780896293 | 0.170320710726512 |
| Q9Y2G5 | Q9Y2G5 | OFUT2_HUMAN | GDP-fucose protein O-fucosyltransferase 2 (EC 2.4.1.221) (Peptide-O-fucosyltransferase 2) (O-FucT-2) | POFUT2 | fucose metabolic process [GO:0006004]; mesoderm formation [GO:0001707]; positive regulation of protein folding [GO:1903334]; protein O-linked fucosylation [GO:0036066]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gene expression [GO:0010468]; regulation of secretion [GO:0051046] | endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794] | peptide-O-fucosyltransferase activity [GO:0046922] | 78433.7976246177 | 0.160610618544655 | 0.0494548950676624 | 0.170320710726512 |
| Q9BSJ8 | Q9BSJ8 | ESYT1_HUMAN | Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) | ESYT1 | endoplasmic reticulum-plasma membrane tethering [GO:0061817]; intermembrane lipid transfer [GO:0120009] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; membrane [GO:0016020] | calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; identical protein binding [GO:0042802]; phosphatidylcholine binding [GO:0031210]; phosphatidylethanolamine binding [GO:0008429]; phosphatidylinositol binding [GO:0035091]; phospholipid transfer activity [GO:0120014] | 40483.760883753246 | -0.136177828306744 | 0.0498558351855872 | 0.171513759660921 |
| Q9Y672 | Q9Y672 | ALG6_HUMAN | Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.267) (Asparagine-linked glycosylation protein 6 homolog) (Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase) | ALG6 | dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; oligosaccharide-lipid intermediate biosynthetic process [GO:0006490]; protein N-linked glycosylation [GO:0006487] | endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] | dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity [GO:0042281]; dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity [GO:0004583]; glucosyltransferase activity [GO:0046527] | 7855.906649572975 | -0.299664767918384 | 0.0499192518935595 | 0.171526269035184 |
| O60613 | O60613 | SEP15_HUMAN | Selenoprotein F (15 kDa selenoprotein) | SELENOF | 'de novo' post-translational protein folding [GO:0051084]; sperm DNA condensation [GO:0035092] | endoplasmic reticulum lumen [GO:0005788] | oxidoreductase activity [GO:0016491]; selenium binding [GO:0008430]; thioredoxin peroxidase activity [GO:0008379] | 86153.1660521061 | 0.441173605951228 | 0.0499200172324423 | 0.171526269035184 |
| O15116 | O15116 | LSM1_HUMAN | U6 snRNA-associated Sm-like protein LSm1 (Cancer-associated Sm-like) (Small nuclear ribonuclear CaSm) | LSM1 | deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; histone mRNA catabolic process [GO:0071044]; mRNA processing [GO:0006397]; negative regulation of neuron differentiation [GO:0045665]; neuron differentiation [GO:0030182]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; stem cell population maintenance [GO:0019827] | axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; Lsm1-7-Pat1 complex [GO:1990726]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904] | mRNA binding [GO:0003729]; pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339] | 19547.542005909898 | -0.723248626895918 | 0.0499573265471182 | 0.171550431646044 |
| P78318 | P78318 | IGBP1_HUMAN | Immunoglobulin-binding protein 1 (B-cell signal transduction molecule alpha 4) (Protein alpha-4) (CD79a-binding protein 1) (Protein phosphatase 2/4/6 regulatory subunit) (Renal carcinoma antigen NY-REN-16) | IGBP1 | B cell activation [GO:0042113]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of dephosphorylation [GO:0035303]; regulation of microtubule-based movement [GO:0060632]; response to interleukin-1 [GO:0070555]; response to tumor necrosis factor [GO:0034612]; signal transduction [GO:0007165] | cytoplasm [GO:0005737]; cytosol [GO:0005829] | protein phosphatase 2A binding [GO:0051721]; protein phosphatase regulator activity [GO:0019888] | 12007.65752478335 | 0.306593349222663 | 0.050054873951604 | 0.171702036160095 |
| Q969S3 | Q969S3 | ZN622_HUMAN | Cytoplasmic 60S subunit biogenesis factor ZNF622 (Zinc finger protein 622) (Zinc finger-like protein 9) | ZNF622 | intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of kinase activity [GO:0033674]; positive regulation of MAPK cascade [GO:0043410]; ribosomal large subunit biogenesis [GO:0042273] | cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, large subunit precursor [GO:0030687] | preribosome binding [GO:1990275]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] | 12294.90720410395 | -0.27854334328429 | 0.0500620832574085 | 0.171702036160095 |
| Q9NQR4 | Q9NQR4 | NIT2_HUMAN | Omega-amidase NIT2 (EC 3.5.1.3) (Nitrilase homolog 2) | NIT2 | asparagine metabolic process [GO:0006528]; glutamine metabolic process [GO:0006541]; oxaloacetate metabolic process [GO:0006107] | centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] | 2-oxoglutaramate amidase activity [GO:0106008]; omega-amidase activity [GO:0050152] | 29405.02969273615 | -0.249638670721761 | 0.0501737137309614 | 0.17198079975779 |
| Q96JA1 | Q96JA1 | LRIG1_HUMAN | Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1) | LRIG1 | hair cycle process [GO:0022405]; innervation [GO:0060384]; otolith morphogenesis [GO:0032474]; sensory perception of sound [GO:0007605] | extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] | 4429.05365419261 | 0.788978248887186 | 0.0503138251949078 | 0.172356791749908 | |
| O95249 | O95249 | GOSR1_HUMAN | Golgi SNAP receptor complex member 1 (28 kDa Golgi SNARE protein) (28 kDa cis-Golgi SNARE p28) (GOS-28) | GOSR1 | endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; inter-Golgi cisterna vesicle-mediated transport [GO:0048219]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle fusion [GO:0006906] | cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; SNARE complex [GO:0031201]; transport vesicle [GO:0030133] | SNAP receptor activity [GO:0005484] | 15465.75003253745 | 0.308930857409832 | 0.0504487699572804 | 0.172714640832599 |
| Q6L8Q7 | Q6L8Q7 | PDE12_HUMAN | 2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-) (Mitochondrial deadenylase) (EC 3.1.13.4) | PDE12 | antiviral innate immune response [GO:0140374]; cellular response to dsRNA [GO:0071359]; cellular response to interferon-alpha [GO:0035457]; cellular response to type II interferon [GO:0071346]; defense response to virus [GO:0051607]; mitochondrial mRNA catabolic process [GO:0000958]; mRNA processing [GO:0006397]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nucleic acid metabolic process [GO:0090304]; positive regulation of viral genome replication [GO:0045070]; regulation of mitochondrial mRNA stability [GO:0044528] | cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] | 3'-5'-RNA exonuclease activity [GO:0000175]; exonuclease activity [GO:0004527]; metal ion binding [GO:0046872]; oligoribonucleotidase activity [GO:0034611]; poly(A)-specific ribonuclease activity [GO:0004535] | 8455.731694894845 | -0.139203350782602 | 0.0505283456324439 | 0.172882612532263 |
| Q9H6S3 | Q9H6S3 | ES8L2_HUMAN | Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) | EPS8L2 | positive regulation of ruffle assembly [GO:1900029]; regulation of Rho protein signal transduction [GO:0035023]; Rho protein signal transduction [GO:0007266]; sensory perception of sound [GO:0007605] | centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587]; stereocilium bundle [GO:0032421]; stereocilium tip [GO:0032426]; vesicle [GO:0031982] | actin binding [GO:0003779]; cadherin binding [GO:0045296] | 8496.272270531264 | -0.238706096580739 | 0.0508383011205805 | 0.173645644214143 |
| Q9NXE4 | Q9NXE4 | NSMA3_HUMAN | Sphingomyelin phosphodiesterase 4 (EC 3.1.4.12) (Neutral sphingomyelinase 3) (nSMase-3) (nSMase3) (Neutral sphingomyelinase III) | SMPD4 | cellular response to tumor necrosis factor [GO:0071356]; ceramide biosynthetic process [GO:0046513]; endoplasmic reticulum organization [GO:0007029]; glycerophospholipid catabolic process [GO:0046475]; sphingomyelin catabolic process [GO:0006685] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nuclear envelope [GO:0005635]; nuclear outer membrane [GO:0005640]; sarcolemma [GO:0042383]; trans-Golgi network [GO:0005802] | metal ion binding [GO:0046872]; sphingomyelin phosphodiesterase activity [GO:0004767]; sphingomyelin phosphodiesterase D activity [GO:0050290] | 4556.618878447455 | -0.548550918855403 | 0.0508346109745326 | 0.173645644214143 |
| Q9Y4P8 | Q9Y4P8 | WIPI2_HUMAN | WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2) (WIPI49-like protein 2) | WIPI2 | autophagosome assembly [GO:0000045]; cellular response to starvation [GO:0009267]; glycophagy [GO:0061723]; nucleophagy [GO:0044804]; protein localization to phagophore assembly site [GO:0034497]; xenophagy [GO:0098792] | cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; nucleoplasm [GO:0005654]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; protein-containing complex [GO:0032991] | phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-5-phosphate binding [GO:0010314] | 20203.5033990729 | 0.374735907693274 | 0.0509143270125345 | 0.17378348003194 |
| Q9P2T1 | Q9P2T1 | GMPR2_HUMAN | GMP reductase 2 (GMPR 2) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2) | GMPR2 | GMP metabolic process [GO:0046037]; purine nucleobase metabolic process [GO:0006144] | cytosol [GO:0005829]; GMP reductase complex [GO:1902560] | GMP reductase activity [GO:0003920]; metal ion binding [GO:0046872] | 11719.73018735705 | -0.311628432287792 | 0.05103501668141 | 0.174090550582101 |
| Q9UMS0 | Q9UMS0 | NFU1_HUMAN | NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (HIRA-interacting protein 5) | NFU1 | iron-sulfur cluster assembly [GO:0016226]; protein maturation by iron-sulfur cluster transfer [GO:0097428] | cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | 4 iron, 4 sulfur cluster binding [GO:0051539]; iron ion binding [GO:0005506] | 6586.77956152124 | 0.622900641697777 | 0.0511270624173117 | 0.174299600274662 |
| P61088 | P61088 | UBE2N_HUMAN | Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N) | UBE2N | antiviral innate immune response [GO:0140374]; DNA double-strand break processing [GO:0000729]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA repair [GO:0045739]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; postreplication repair [GO:0006301]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; regulation of DNA repair [GO:0006282]; T cell receptor signaling pathway [GO:0050852] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; UBC13-MMS2 complex [GO:0031372]; UBC13-UEV1A complex [GO:0035370]; ubiquitin conjugating enzyme complex [GO:0031371]; ubiquitin ligase complex [GO:0000151] | ATP binding [GO:0005524]; RNA binding [GO:0003723]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activator activity [GO:0097027]; ubiquitin-protein transferase activity [GO:0004842] | 117770.21222655149 | 0.314477653357706 | 0.0512633830314771 | 0.174659247297865 |
| Q96GK7 | Q96GK7 | FAH2A_HUMAN | Fumarylacetoacetate hydrolase domain-containing protein 2A (EC 3.-.-.-) | FAHD2A | hydrolase activity [GO:0016787]; metal ion binding [GO:0046872] | 11078.5570118183 | -0.195433425509505 | 0.0516408196452007 | 0.175462914028704 | ||
| O95297 | O95297 | MPZL1_HUMAN | Myelin protein zero-like protein 1 (Protein zero-related) | MPZL1 | cell-cell signaling [GO:0007267]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] | cell surface [GO:0009986]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886] | structural molecule activity [GO:0005198] | 66325.03608529744 | 0.333708241513063 | 0.051648117919275 | 0.175462914028704 |
| O94979 | O94979 | SC31A_HUMAN | Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) | SEC31A | COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; response to calcium ion [GO:0051592] | COPII vesicle coat [GO:0030127]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471]; vesicle coat [GO:0030120] | calcium-dependent protein binding [GO:0048306]; structural molecule activity [GO:0005198] | 67632.86379693466 | -0.145139108922034 | 0.0515826617839654 | 0.175462914028704 |
| Q96TA2 | Q96TA2 | YMEL1_HUMAN | ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (EC 3.6.-.-) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin-associated metalloprotease) (PAMP) (YME1-like protein 1) | YME1L1 | cell population proliferation [GO:0008283]; mitochondrial protein catabolic process [GO:0035694]; mitochondrial protein processing [GO:0034982]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; protein hexamerization [GO:0034214]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515] | membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nuclear body [GO:0016604] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent peptidase activity [GO:0004176]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] | 7978.435297138175 | 0.333283026846504 | 0.0516541017648921 | 0.175462914028704 |
| O95025 | O95025 | SEM3D_HUMAN | Semaphorin-3D | SEMA3D | axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526] | extracellular space [GO:0005615]; plasma membrane [GO:0005886] | chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215] | 5334.93729860181 | -0.885102990338496 | 0.0517300223466255 | 0.175615522238454 |
| O94854 | O94854 | K0754_HUMAN | Microtubule-actin cross-linking factor 1, isoforms 6/7 (Uncharacterized protein KIAA0754) | MACF1 | intermediate filament cytoskeleton organization [GO:0045104]; regulation of focal adhesion assembly [GO:0051893]; regulation of microtubule-based process [GO:0032886]; wound healing [GO:0042060] | actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; intermediate filament [GO:0005882]; membrane [GO:0016020]; microtubule [GO:0005874] | cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; microtubule binding [GO:0008017]; structural molecule activity [GO:0005198] | 4381.96688424612 | -0.548108980377656 | 0.0519814556447564 | 0.176363429750413 |
| Q8N3P4 | Q8N3P4 | VPS8_HUMAN | Vacuolar protein sorting-associated protein 8 homolog | VPS8 | endosomal vesicle fusion [GO:0034058]; protein targeting to vacuole [GO:0006623]; regulation of SNARE complex assembly [GO:0035542] | CORVET complex [GO:0033263]; early endosome [GO:0005769]; HOPS complex [GO:0030897]; late endosome [GO:0005770] | metal ion binding [GO:0046872] | 964.43958409026 | -0.726165740938599 | 0.0521535831799918 | 0.176841533391881 |
| O75063 | O75063 | XYLK_HUMAN | Glycosaminoglycan xylosylkinase (EC 2.7.1.-) (Xylose kinase) | FAM20B | phosphorylation [GO:0016310]; proteoglycan biosynthetic process [GO:0030166] | Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654] | ATP binding [GO:0005524]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; phosphotransferase activity, alcohol group as acceptor [GO:0016773] | 15558.105436955051 | 0.298767946014577 | 0.0526419053396459 | 0.178390571563656 |
| Q12979 | Q12979 | ABR_HUMAN | Active breakpoint cluster region-related protein | ABR | activation of GTPase activity [GO:0090630]; modulation of chemical synaptic transmission [GO:0050804]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264] | axon [GO:0030424]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; Schaffer collateral - CA1 synapse [GO:0098685] | GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] | 11810.59379828245 | -0.247717925350049 | 0.0527672937080418 | 0.178708599013607 |
| O00488 | O00488 | ZN593_HUMAN | Zinc finger protein 593 (Zinc finger protein T86) | ZNF593 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1903026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; ribosome biogenesis [GO:0042254] | cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] | DNA binding [GO:0003677]; preribosome binding [GO:1990275]; zinc ion binding [GO:0008270] | 10932.666331117449 | 0.512242518493033 | 0.0530116128379826 | 0.179428792317807 |
| Q9Y625 | Q9Y625 | GPC6_HUMAN | Glypican-6 [Cleaved into: Secreted glypican-6] | GPC6 | cell migration [GO:0016477]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of signal transduction [GO:0009966] | cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; synapse [GO:0045202] | coreceptor activity [GO:0015026] | 9364.083261133641 | -0.417889521957484 | 0.0530664929841924 | 0.17950731298414 |
| P63313 | P63313 | TYB10_HUMAN | Thymosin beta-10 | TMSB10 | actin filament organization [GO:0007015]; regulation of cell migration [GO:0030334]; sequestering of actin monomers [GO:0042989] | cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] | actin monomer binding [GO:0003785] | 33528.833262431 | 0.632053773925793 | 0.0532307117916433 | 0.17984806977427 |
| P07858 | P07858 | CATB_HUMAN | Cathepsin B (EC 3.4.22.1) (APP secretase) (APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] | CTSB | cellular response to thyroid hormone stimulus [GO:0097067]; collagen catabolic process [GO:0030574]; decidualization [GO:0046697]; epithelial cell differentiation [GO:0030855]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of apoptotic process [GO:0042981]; symbiont entry into host cell [GO:0046718]; thyroid hormone generation [GO:0006590] | apical plasma membrane [GO:0016324]; collagen-containing extracellular matrix [GO:0062023]; endolysosome lumen [GO:0036021]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; lysosome [GO:0005764]; melanosome [GO:0042470]; peptidase inhibitor complex [GO:1904090]; perinuclear region of cytoplasm [GO:0048471] | collagen binding [GO:0005518]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; peptidase activity [GO:0008233]; proteoglycan binding [GO:0043394] | 232513.325508346 | 0.194846676919683 | 0.0533209783243963 | 0.180045687238396 |
| Q13614 | Q13614 | MTMR2_HUMAN | Myotubularin-related protein 2 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64) | MTMR2 | dendritic spine maintenance [GO:0097062]; myelin assembly [GO:0032288]; negative regulation of endocytosis [GO:0045806]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of myelination [GO:0031642]; negative regulation of receptor catabolic process [GO:2000645]; negative regulation of receptor internalization [GO:0002091]; neuron development [GO:0048666]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of early endosome to late endosome transport [GO:2000643]; protein dephosphorylation [GO:0006470]; regulation of phosphatidylinositol dephosphorylation [GO:0060304] | axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; synaptic membrane [GO:0097060]; synaptic vesicle [GO:0008021]; vacuolar membrane [GO:0005774] | identical protein binding [GO:0042802]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138] | 9859.06146309739 | -0.565897978266352 | 0.0534382888276208 | 0.180265287140693 |
| Q12846 | Q12846 | STX4_HUMAN | Syntaxin-4 (Renal carcinoma antigen NY-REN-31) | STX4 | cellular response to oxidative stress [GO:0034599]; cellular response to type II interferon [GO:0071346]; cornified envelope assembly [GO:1903575]; exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]; long-term synaptic potentiation [GO:0060291]; organelle fusion [GO:0048284]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemotaxis [GO:0050921]; positive regulation of eosinophil degranulation [GO:0043311]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein localization to cell surface [GO:0034394]; regulation of exocytosis [GO:0017157]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; SNARE complex assembly [GO:0035493]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] | basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endomembrane system [GO:0012505]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; lateral loop [GO:0043219]; membrane [GO:0016020]; myelin sheath adaxonal region [GO:0035749]; neuron projection membrane [GO:0032589]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynaptic active zone membrane [GO:0048787]; SNARE complex [GO:0031201]; somatodendritic compartment [GO:0036477]; specific granule [GO:0042581]; storage vacuole [GO:0000322]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802]; vacuole [GO:0005773] | SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; sphingomyelin phosphodiesterase activator activity [GO:0016230] | 16310.57856808255 | 0.274431802007476 | 0.0534496439104066 | 0.180265287140693 |
| O14933 | O14933 | UB2L6_HUMAN | Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L6) (Retinoic acid-induced gene B protein) (RIG-B) (UbcH8) (Ubiquitin carrier protein L6) (Ubiquitin-protein ligase L6) | UBE2L6 | innate immune response [GO:0045087]; ISG15-protein conjugation [GO:0032020]; protein modification process [GO:0036211]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] | ISG15 transferase activity [GO:0042296]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842] | 5905.753921113515 | 0.579113502373875 | 0.0535730615213802 | 0.180574043176764 |
| P62253 | P62253 | UB2G1_HUMAN | Ubiquitin-conjugating enzyme E2 G1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme G1) (E217K) (UBC7) (Ubiquitin carrier protein G1) (Ubiquitin-protein ligase G1) [Cleaved into: Ubiquitin-conjugating enzyme E2 G1, N-terminally processed] | UBE2G1 | proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] | cytosol [GO:0005829]; extracellular exosome [GO:0070062] | ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842] | 10049.975254851066 | 0.476840671112807 | 0.0539568427233046 | 0.181651497843282 |
| Q8WVF1 | Q8WVF1 | OSCP1_HUMAN | Protein OSCP1 (hOSCP1) (Organic solute transport protein 1) (Oxidored-nitro domain-containing protein 1) | OSCP1 | xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] | basal plasma membrane [GO:0009925]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] | transmembrane transporter activity [GO:0022857] | 8034.579401855265 | 0.383509715946887 | 0.0540479836783902 | 0.181850282376341 |
| P49411 | P49411 | EFTU_HUMAN | Elongation factor Tu, mitochondrial (EF-Tu) (P43) | TUFM | mitochondrial translational elongation [GO:0070125]; response to ethanol [GO:0045471]; translational elongation [GO:0006414] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial nucleoid [GO:0042645]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; synapse [GO:0045202] | GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746] | 49434.7163596885 | 0.141868243671286 | 0.0542088933331496 | 0.182278523977157 |
| Q9HD42 | Q9HD42 | CHM1A_HUMAN | Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Vacuolar protein sorting-associated protein 46-1) (Vps46-1) (hVps46-1) | CHMP1A | autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cell division [GO:0051301]; endosome transport via multivesicular body sorting pathway [GO:0032509]; ESCRT III complex disassembly [GO:1904903]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic chromosome condensation [GO:0007076]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; negative regulation of gene expression [GO:0010629]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle fusion with vacuole [GO:0051469]; vesicle-mediated transport [GO:0016192]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702] | amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear matrix [GO:0016363]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886] | identical protein binding [GO:0042802]; metallopeptidase activity [GO:0008237]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270] | 44805.104699675096 | 0.363162493417207 | 0.0543124872781778 | 0.182307199596064 |
| Q9UI09 | Q9UI09 | NDUAC_HUMAN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (13 kDa differentiation-associated protein) (Complex I-B17.2) (CI-B17.2) (CIB17.2) (NADH-ubiquinone oxidoreductase subunit B17.2) | NDUFA12 | aerobic respiration [GO:0009060]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; respiratory gaseous exchange by respiratory system [GO:0007585]; response to oxidative stress [GO:0006979] | cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739] | NADH dehydrogenase (ubiquinone) activity [GO:0008137] | 31350.131423522747 | 0.432322370627364 | 0.0542833004991535 | 0.182307199596064 |
| O00244 | O00244 | ATOX1_HUMAN | Copper transport protein ATOX1 (Metal transport protein ATX1) | ATOX1 | copper ion transport [GO:0006825]; intracellular copper ion homeostasis [GO:0006878]; response to oxidative stress [GO:0006979] | cytosol [GO:0005829] | copper chaperone activity [GO:0016531]; copper ion binding [GO:0005507]; copper-dependent protein binding [GO:0032767]; cuprous ion binding [GO:1903136]; metallochaperone activity [GO:0016530] | 107680.8770699965 | -0.281132815940829 | 0.054596138833665 | 0.183150812688896 |
| O43169 | O43169 | CYB5B_HUMAN | Cytochrome b5 type B (Cytochrome b5 outer mitochondrial membrane isoform) | CYB5B | nitric oxide biosynthetic process [GO:0006809]; response to oxidative stress [GO:0006979]; xenobiotic metabolic process [GO:0006805] | endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; nitric-oxide synthase complex [GO:1903958] | enzyme activator activity [GO:0008047]; heme binding [GO:0020037]; metal ion binding [GO:0046872] | 121626.9585520715 | 0.308929205570028 | 0.0547632993768515 | 0.183540329465338 |
| Q8N699 | Q8N699 | MYCT1_HUMAN | Myc target protein 1 (Myc target in myeloid cells protein 1) | MYCT1 | hematopoietic stem cell homeostasis [GO:0061484] | intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] | 47378.179384373245 | 0.415708251443099 | 0.0547770379678586 | 0.183540329465338 | |
| P06737 | P06737 | PYGL_HUMAN | Glycogen phosphorylase, liver form (EC 2.4.1.1) | PYGL | 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; glucose homeostasis [GO:0042593]; glycogen catabolic process [GO:0005980]; glycogen metabolic process [GO:0005977]; necroptotic process [GO:0070266]; response to bacterium [GO:0009617] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774] | AMP binding [GO:0016208]; ATP binding [GO:0005524]; bile acid binding [GO:0032052]; glucose binding [GO:0005536]; glycogen phosphorylase activity [GO:0008184]; identical protein binding [GO:0042802]; linear malto-oligosaccharide phosphorylase activity [GO:0102250]; purine nucleobase binding [GO:0002060]; pyridoxal phosphate binding [GO:0030170]; SHG alpha-glucan phosphorylase activity [GO:0102499]; vitamin binding [GO:0019842] | 59747.7951251388 | 0.124064589704277 | 0.0548957812915199 | 0.183829489833186 |
| Q68CQ7 | Q68CQ7 | GL8D1_HUMAN | Glycosyltransferase 8 domain-containing protein 1 (EC 2.4.1.-) | GLT8D1 | Golgi apparatus [GO:0005794]; membrane [GO:0016020] | UDP-glycosyltransferase activity [GO:0008194] | 30051.18996987915 | -0.258195665736583 | 0.0549926478863595 | 0.18393644800715 | |
| Q05519 | Q05519 | SRS11_HUMAN | Serine/arginine-rich splicing factor 11 (Arginine-rich 54 kDa nuclear protein) (p54) (Splicing factor, arginine/serine-rich 11) | SRSF11 | mRNA processing [GO:0006397]; RNA splicing [GO:0008380] | nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | identical protein binding [GO:0042802]; RNA binding [GO:0003723] | 20206.890452545602 | 0.307981409406953 | 0.0550735150865652 | 0.184072621910666 |
| Q9Y320 | Q9Y320 | TMX2_HUMAN | Thioredoxin-related transmembrane protein 2 (Cell proliferation-inducing gene 26 protein) (Thioredoxin domain-containing protein 14) | TMX2 | brain development [GO:0007420] | endoplasmic reticulum membrane [GO:0005789]; membrane-bounded organelle [GO:0043227]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] | disulfide oxidoreductase activity [GO:0015036]; identical protein binding [GO:0042802] | 22059.1977017665 | -0.159976396140162 | 0.0550983351148057 | 0.184072621910666 |
| Q9Y5R8 | Q9Y5R8 | TPPC1_HUMAN | Trafficking protein particle complex subunit 1 (BET5 homolog) (Multiple myeloma protein 2) (MUM-2) | TRAPPC1 | COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022] | azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072] | 11619.77453258135 | -0.419141331136418 | 0.0554049251725019 | 0.18498780555533 | |
| Q9ULG6 | Q9ULG6 | CCPG1_HUMAN | Cell cycle progression protein 1 (Cell cycle progression restoration protein 8) | CCPG1 | cell cycle [GO:0007049]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944] | membrane [GO:0016020] | 23824.5239137742 | 0.163899112995878 | 0.0556722196669704 | 0.185718700142789 | |
| O15394 | O15394 | NCAM2_HUMAN | Neural cell adhesion molecule 2 (N-CAM-2) (NCAM-2) | NCAM2 | axonal fasciculation [GO:0007413]; neuron cell-cell adhesion [GO:0007158] | axon [GO:0030424]; membrane [GO:0016020]; nuclear body [GO:0016604]; plasma membrane [GO:0005886] | identical protein binding [GO:0042802] | 9727.164929496194 | -0.75375124850245 | 0.055689387847264 | 0.185718700142789 |
| P17931 | P17931 | LEG3_HUMAN | Galectin-3 (Gal-3) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Galactose-specific lectin 3) (Galactoside-binding protein) (GALBP) (IgE-binding protein) (L-31) (Laminin-binding protein) (Lectin L-29) (Mac-2 antigen) | LGALS3 | eosinophil chemotaxis [GO:0048245]; epithelial cell differentiation [GO:0030855]; innate immune response [GO:0045087]; macrophage chemotaxis [GO:0048246]; monocyte chemotaxis [GO:0002548]; mononuclear cell migration [GO:0071674]; mRNA processing [GO:0006397]; negative regulation of endocytosis [GO:0045806]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of immunological synapse formation [GO:2000521]; negative regulation of protein tyrosine phosphatase activity [GO:1903614]; negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:2001189]; negative regulation of T cell receptor signaling pathway [GO:0050860]; neutrophil chemotaxis [GO:0030593]; positive chemotaxis [GO:0050918]; positive regulation of calcium ion import [GO:0090280]; positive regulation of mononuclear cell migration [GO:0071677]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein-containing complex assembly [GO:0031334]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of T cell apoptotic process [GO:0070232]; regulation of T cell proliferation [GO:0042129]; RNA splicing [GO:0008380] | cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; immunological synapse [GO:0001772]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; spliceosomal complex [GO:0005681] | carbohydrate binding [GO:0030246]; chemoattractant activity [GO:0042056]; disaccharide binding [GO:0048030]; IgE binding [GO:0019863]; laminin binding [GO:0043236]; molecular condensate scaffold activity [GO:0140693]; protein phosphatase binding [GO:0019903]; protein phosphatase inhibitor activity [GO:0004864]; RNA binding [GO:0003723] | 303869.101453971 | 0.215638398180522 | 0.0559320302756168 | 0.186199109013892 |
| O75351 | O75351 | VPS4B_HUMAN | Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) (Cell migration-inducing gene 1 protein) (Suppressor of K(+) transport growth defect 1) (Protein SKD1) | VPS4B | angiogenesis [GO:0001525]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; canonical Wnt signaling pathway [GO:0060070]; cholesterol transport [GO:0030301]; endosomal transport [GO:0016197]; endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; ESCRT III complex disassembly [GO:1904903]; establishment of blood-brain barrier [GO:0060856]; late endosomal microautophagy [GO:0061738]; late endosome to lysosome transport via multivesicular body sorting pathway [GO:0061764]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; negative regulation of exosomal secretion [GO:1903542]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; positive regulation of centriole elongation [GO:1903724]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; potassium ion transport [GO:0006813]; protein depolymerization [GO:0051261]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; response to lipid [GO:0033993]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; vacuole organization [GO:0007033]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702] | ATPase complex [GO:1904949]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; late endosome membrane [GO:0031902]; midbody [GO:0030496]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle pole [GO:0000922] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877] | 27290.39133271065 | 0.296293277803937 | 0.0559246642940423 | 0.186199109013892 |
| Q9H7D0 | Q9H7D0 | DOCK5_HUMAN | Dedicator of cytokinesis protein 5 | DOCK5 | bone remodeling [GO:0046849]; cell migration [GO:0016477]; myoblast fusion [GO:0007520]; negative regulation of vascular associated smooth muscle contraction [GO:1904694]; podosome assembly [GO:0071800]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; Rac protein signal transduction [GO:0016601] | anchoring junction [GO:0070161]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; podosome [GO:0002102] | GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] | 7797.181901821024 | -0.275604585988884 | 0.0560779688877255 | 0.186475854305889 |
| P31937 | P31937 | 3HIDH_HUMAN | 3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) (EC 1.1.1.31) | HIBADH | valine catabolic process [GO:0006574] | mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] | 3-hydroxyisobutyrate dehydrogenase activity [GO:0008442]; NAD binding [GO:0051287]; NADP binding [GO:0050661] | 25378.8369718224 | 0.161615010744415 | 0.0561062826210822 | 0.186475854305889 |
| P62857 | P62857 | RS28_HUMAN | Small ribosomal subunit protein eS28 (40S ribosomal protein S28) | RPS28 | cytoplasmic translation [GO:0002181]; maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; ribosome biogenesis [GO:0042254]; rRNA processing [GO:0006364]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytoplasmic side of rough endoplasmic reticulum membrane [GO:0098556]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribosome [GO:0005840]; small ribosomal subunit [GO:0015935]; small-subunit processome [GO:0032040]; synapse [GO:0045202] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 2587153.0665373 | -0.228466084857286 | 0.0561138954450301 | 0.186475854305889 |
| Q9H082 | Q9H082 | RB33B_HUMAN | Ras-related protein Rab-33B | RAB33B | autophagosome assembly [GO:0000045]; intra-Golgi vesicle-mediated transport [GO:0006891]; negative regulation of constitutive secretory pathway [GO:1903434]; protein localization to Golgi apparatus [GO:0034067]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; regulation of exocytosis [GO:0017157]; regulation of Golgi organization [GO:1903358]; regulation of retrograde vesicle-mediated transport, Golgi to ER [GO:2000156]; skeletal system morphogenesis [GO:0048705] | endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; presynapse [GO:0098793] | GTP binding [GO:0005525]; GTPase activity [GO:0003924] | 5595.615203385635 | -0.462080448789644 | 0.0564180060744015 | 0.18737656648157 |
| P62256 | P62256 | UBE2H_HUMAN | Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UbcH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H) | UBE2H | proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] | cytosol [GO:0005829]; nucleus [GO:0005634] | ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842] | 52836.45198378405 | 0.506580789156998 | 0.056676150263156 | 0.188013505498268 |
| Q14156 | Q14156 | EFR3A_HUMAN | Protein EFR3 homolog A (Protein EFR3-like) | EFR3A | phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659] | cytosol [GO:0005829]; plasma membrane [GO:0005886] | 6623.86838119572 | -0.406947179981501 | 0.0569010824615751 | 0.188649229506896 | |
| O75503 | O75503 | CLN5_HUMAN | Bis(monoacylglycero)phosphate synthase CLN5 (BMP synthase CLN5) (EC 2.3.1.-) (Ceroid-lipofuscinosis neuronal protein 5) (Protein CLN5) (Palmitoyl protein thioesterase CLN5) (EC 3.1.2.22) (S-depalmitoylase CLN5) [Cleaved into: Bis(monoacylglycero)phosphate synthase CLN5, secreted form] | CLN5 | brain development [GO:0007420]; glycosylation [GO:0070085]; lysosomal lumen acidification [GO:0007042]; lysosome organization [GO:0007040]; neurogenesis [GO:0022008]; neuron maturation [GO:0042551]; positive regulation of GTP binding [GO:1904426]; protein catabolic process [GO:0030163]; retrograde transport, endosome to Golgi [GO:0042147]; signal peptide processing [GO:0006465]; visual perception [GO:0007601] | cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; vacuolar lumen [GO:0005775] | bis(monoacylglycero)phosphate synthase activity [GO:0160121]; hydrolase activity, acting on glycosyl bonds [GO:0016798]; long-chain fatty acyl-CoA hydrolase activity [GO:0052816]; mannose binding [GO:0005537] | 17300.05603952735 | 0.369156891458421 | 0.0572144629818229 | 0.189577279096496 |
| Q00059 | Q00059 | TFAM_HUMAN | Transcription factor A, mitochondrial (mtTFA) (Mitochondrial transcription factor 1) (MtTF1) (Transcription factor 6) (TCF-6) (Transcription factor 6-like 2) | TFAM | mitochondrial respiratory chain complex assembly [GO:0033108]; mitochondrial transcription [GO:0006390]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hypoxia [GO:0001666]; response to nutrient [GO:0007584]; transcription initiation at mitochondrial promoter [GO:0006391] | cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] | chromatin binding [GO:0003682]; DNA binding, bending [GO:0008301]; heat shock protein binding [GO:0031072]; mitochondrial promoter sequence-specific DNA binding [GO:0001018]; mitochondrial transcription factor activity [GO:0034246]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223] | 23449.58382292325 | 0.318074763791521 | 0.0572918946463504 | 0.189722896005974 |
| O43399 | O43399 | TPD54_HUMAN | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | TPD52L2 | carbohydrate metabolic process [GO:0005975]; regulation of cell population proliferation [GO:0042127] | cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471] | protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723] | 177562.7545612335 | 0.252878702680847 | 0.0576878752891288 | 0.190922605951053 |
| Q8WUM9 | Q8WUM9 | S20A1_HUMAN | Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1) | SLC20A1 | biomineral tissue development [GO:0031214]; cell population proliferation [GO:0008283]; monoatomic ion transport [GO:0006811]; phosphate ion transmembrane transport [GO:0035435]; phosphate-containing compound metabolic process [GO:0006796]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123] | membrane [GO:0016020]; plasma membrane [GO:0005886] | high-affinity inorganic phosphate:sodium symporter activity [GO:0005316]; inorganic phosphate transmembrane transporter activity [GO:0005315]; signaling receptor activity [GO:0038023]; sodium:phosphate symporter activity [GO:0005436] | 7446.39642844413 | 1.12005619627435 | 0.0578473226097252 | 0.191338546355343 |
| Q9BQS8 | Q9BQS8 | FYCO1_HUMAN | FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7) | FYCO1 | plus-end-directed vesicle transport along microtubule [GO:0072383]; positive regulation of autophagosome maturation [GO:1901098] | autophagosome [GO:0005776]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosome [GO:0005764]; membrane [GO:0016020] | metal ion binding [GO:0046872] | 7307.523970079805 | -0.436195453059135 | 0.0580028545127335 | 0.191599542414149 |
| O75157 | O75157 | T22D2_HUMAN | TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4) | TSC22D2 | negative regulation of cell cycle [GO:0045786]; regulation of transcription by RNA polymerase II [GO:0006357]; response to osmotic stress [GO:0006970] | 23191.41162332645 | 0.294568687924212 | 0.0580276764529968 | 0.191599542414149 | ||
| P62191 | P62191 | PRS4_HUMAN | 26S proteasome regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1) | PSMC1 | proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] | cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proteasome-activating activity [GO:0036402]; RNA binding [GO:0003723] | 60937.20688012215 | 0.216329522914235 | 0.0582691498295234 | 0.1921728771444 |
| Q5R3I4 | Q5R3I4 | TTC38_HUMAN | Tetratricopeptide repeat protein 38 (TPR repeat protein 38) | TTC38 | extracellular exosome [GO:0070062] | 8983.030999141723 | -0.303767864427315 | 0.058263612853802 | 0.1921728771444 | ||
| Q9NRZ7 | Q9NRZ7 | PLCC_HUMAN | 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 3) (1-AGP acyltransferase 3) (1-AGPAT 3) (Lysophosphatidic acid acyltransferase gamma) (LPAAT-gamma) | AGPAT3 | CDP-diacylglycerol biosynthetic process [GO:0016024]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid biosynthetic process [GO:0008654] | endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886] | 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841] | 10323.53131912185 | -0.461432875498907 | 0.058760368450159 | 0.193680190598372 |
| Q66K79 | Q66K79 | CBPZ_HUMAN | Carboxypeptidase Z (CPZ) (EC 3.4.17.-) | CPZ | peptide metabolic process [GO:0006518]; protein processing [GO:0016485]; proteolysis [GO:0006508]; Wnt signaling pathway [GO:0016055] | extracellular space [GO:0005615] | metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] | 6869.956699546745 | 0.54862745830989 | 0.0589327226188956 | 0.194011725897731 |
| P42785 | P42785 | PCP_HUMAN | Lysosomal Pro-X carboxypeptidase (EC 3.4.16.2) (Angiotensinase C) (Lysosomal carboxypeptidase C) (Proline carboxypeptidase) (Prolylcarboxypeptidase) (PRCP) | PRCP | angiogenesis involved in wound healing [GO:0060055]; energy homeostasis [GO:0097009]; glucose homeostasis [GO:0042593]; negative regulation of systemic arterial blood pressure [GO:0003085]; plasma kallikrein-kinin cascade [GO:0002353]; proteolysis [GO:0006508]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of thyroid hormone mediated signaling pathway [GO:0002155] | azurophil granule membrane [GO:0035577]; basal part of cell [GO:0045178]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] | dipeptidyl-peptidase activity [GO:0008239]; serine-type carboxypeptidase activity [GO:0004185] | 111320.43266091251 | 0.200924937090528 | 0.0589973272051297 | 0.194011725897731 |
| P42696 | P42696 | RBM34_HUMAN | RNA-binding protein 34 (RNA-binding motif protein 34) | RBM34 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463] | chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] | RNA binding [GO:0003723]; rRNA binding [GO:0019843] | 7034.535887119595 | 0.304358800621458 | 0.0589224661092993 | 0.194011725897731 |
| Q9NP61 | Q9NP61 | ARFG3_HUMAN | ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3) | ARFGAP3 | COPI coating of Golgi vesicle [GO:0048205]; intracellular protein transport [GO:0006886]; protein secretion [GO:0009306]; vesicle-mediated transport [GO:0016192] | cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] | GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] | 36811.66480442425 | 0.123690287175056 | 0.0591232889582095 | 0.19431122693574 |
| Q9BVQ7 | Q9BVQ7 | AFG2B_HUMAN | ATPase family gene 2 protein homolog B (EC 3.6.4.10) (AFG2 AAA ATPase homolog B) (Ribosome biogenesis protein SPATA5L1) (Spermatogenesis-associated protein 5-like protein 1) | AFG2B | ribosomal large subunit biogenesis [GO:0042273] | cytoplasm [GO:0005737]; nucleus [GO:0005634]; spindle [GO:0005819] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; preribosome binding [GO:1990275] | 1296.80731346064 | -0.591161852338211 | 0.0596149200743333 | 0.195813412835462 |
| Q5HYI8 | Q5HYI8 | RABL3_HUMAN | Rab-like protein 3 | RABL3 | B cell differentiation [GO:0030183]; intracellular protein transport [GO:0006886]; natural killer cell differentiation [GO:0001779]; protein stabilization [GO:0050821]; regulation of protein lipidation [GO:1903059]; regulation of Ras protein signal transduction [GO:0046578]; T cell differentiation in thymus [GO:0033077] | endomembrane system [GO:0012505] | GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein homodimerization activity [GO:0042803] | 11291.6598492507 | 0.147358963279311 | 0.060057888572221 | 0.197154111616572 |
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| Q15149 | |||||||||
| Q99715 | |||||||||
| P02452 | |||||||||
| P02751 | |||||||||
| P98160 | |||||||||
| P08123 | |||||||||
| P02461 | |||||||||
| P07996 | |||||||||
| Q8WWI1 | |||||||||
| P05997 | |||||||||
| P20908 | |||||||||
| Q8WUJ3 | |||||||||
| P21333 | |||||||||
| O75369 | |||||||||
| Q15063 | |||||||||
| P02786 | |||||||||
| Q12884 | |||||||||
| P12814 | |||||||||
| Q9UDY2 | |||||||||
| Q14195 | |||||||||
| Q02952 | |||||||||
| Q9NZM1 | |||||||||
| P35579 | |||||||||
| P35354 | |||||||||
| P47895 | |||||||||
| Q09666 | |||||||||
| P11717 | |||||||||
| Q14112 | |||||||||
| Q13620 | |||||||||
| P43490 | |||||||||
| Q3SY69 | |||||||||
| P17812 | |||||||||
| P21980 | |||||||||
| Q16647 | |||||||||
| P01024 | |||||||||
| Q5SW79 | |||||||||
| P06396 | |||||||||
| P12111 | |||||||||
| P35221 | |||||||||
| P12429 | |||||||||
| P78559 | |||||||||
| Q76M96 | |||||||||
| Q16881 | |||||||||
| P07093 | |||||||||
| P27487 | |||||||||
| P15144 | |||||||||
| Q9H5V8 | |||||||||
| P08729 | |||||||||
| Q04828 | |||||||||
| O94925 | |||||||||
| P08473 | |||||||||
| Q8IVL5 | |||||||||
| P35442 | |||||||||
| O60716 | |||||||||
| P08253 | |||||||||
| Q16822 | |||||||||
| Q9UJ72 | |||||||||
| Q9Y617 | |||||||||
| Q8WX93 | |||||||||
| Q32MZ4 | |||||||||
| Q6P179 | |||||||||
| P48681 | |||||||||
| O95340 | |||||||||
| P21580 | |||||||||
| Q00341 | |||||||||
| P49748 | |||||||||
| O43854 | |||||||||
| P07942 | |||||||||
| Q96KC8 | |||||||||
| Q96PD2 | |||||||||
| Q13418 | |||||||||
| Q7Z7G0 | |||||||||
| Q04446 | |||||||||
| P19022 | |||||||||
| O00469 | |||||||||
| Q8WUF5 | |||||||||
| Q14767 | |||||||||
| Q13308 | |||||||||
| P46940 | |||||||||
| Q9NZ08 | |||||||||
| O60488 | |||||||||
| P35222 | |||||||||
| Q9H4M9 | |||||||||
| Q9NZU5 | |||||||||
| Q15113 | |||||||||
| O94808 | |||||||||
| Q9UI42 | |||||||||
| Q15417 | |||||||||
| Q15582 | |||||||||
| P35908 | |||||||||
| P00750 | |||||||||
| Q9UHD8 | |||||||||
| P11047 | |||||||||
| Q8N6G6 | |||||||||
| Q05682 | |||||||||
| P17342 | |||||||||
| Q16363 | |||||||||
| Q9NR12 | |||||||||
| P05362 | |||||||||
| P00966 | |||||||||
| P05120 | |||||||||
| P15121 | |||||||||
| P04179 | |||||||||
| Q15785 | |||||||||
| O60271 | |||||||||
| Q9Y6N5 | |||||||||
| Q9P0V9 | |||||||||
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