Selected Cell
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stat_data__min_2_Peptides
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| O15382 | O15382 | BCAT2_HUMAN | Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT(m)) (EC 2.6.1.42) (Placental protein 18) (PP18) | BCAT2 | amino acid biosynthetic process [GO:0008652]; branched-chain amino acid biosynthetic process [GO:0009082]; cellular response to leukemia inhibitory factor [GO:1990830]; isoleucine catabolic process [GO:0006550]; leucine biosynthetic process [GO:0009098]; lipid metabolic process [GO:0006629]; regulation of hormone levels [GO:0010817]; valine biosynthetic process [GO:0009099] | mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] | branched-chain-amino-acid transaminase activity [GO:0004084]; L-isoleucine transaminase activity [GO:0052656]; L-leucine transaminase activity [GO:0052654]; L-leucine:2-oxoglutarate aminotransferase activity [GO:0050048]; L-valine transaminase activity [GO:0052655] | 8938.788505862274 | -0.275523900402514 | 0.0122307377482104 | 0.0554838751652205 |
| O43719 | O43719 | HTSF1_HUMAN | 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1) | HTATSF1 | double-strand break repair via homologous recombination [GO:0000724]; mRNA splicing, via spliceosome [GO:0000398]; protein localization to site of double-strand break [GO:1990166]; U2-type prespliceosome assembly [GO:1903241] | nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type spliceosomal complex [GO:0005684] | chromatin-protein adaptor activity [GO:0140463]; poly-ADP-D-ribose modification-dependent protein binding [GO:0160004]; RNA binding [GO:0003723] | 6082.1084009251845 | 0.447080352719553 | 0.0122256351203067 | 0.0554838751652205 |
| Q96T76 | Q96T76 | MMS19_HUMAN | MMS19 nucleotide excision repair protein homolog (hMMS19) (MET18 homolog) (MMS19-like protein) | MMS19 | chromosome segregation [GO:0007059]; DNA repair [GO:0006281]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by iron-sulfur cluster transfer [GO:0097428] | centrosome [GO:0005813]; CIA complex [GO:0097361]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; MMXD complex [GO:0071817]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; transcription factor TFIIH holo complex [GO:0005675] | enzyme binding [GO:0019899]; nuclear estrogen receptor binding [GO:0030331]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor complex adaptor activity [GO:0030159]; transcription coactivator activity [GO:0003713] | 8018.847107991531 | -0.402147658280359 | 0.0122541819555717 | 0.0555457559682153 |
| Q9P0L0 | Q9P0L0 | VAPA_HUMAN | Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33) | VAPA | ceramide transport [GO:0035627]; cholesterol transport [GO:0030301]; COPII-coated vesicle budding [GO:0090114]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endoplasmic reticulum-plasma membrane tethering [GO:0061817]; membrane fusion [GO:0061025]; negative regulation by host of viral genome replication [GO:0044828]; neuron projection development [GO:0031175]; phospholipid transport [GO:0015914]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein localization to endoplasmic reticulum [GO:0070972]; sphingomyelin biosynthetic process [GO:0006686]; sterol transport [GO:0015918]; viral release from host cell [GO:0019076] | azurophil granule membrane [GO:0035577]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; microtubule cytoskeleton [GO:0015630]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; vesicle [GO:0031982] | cadherin binding [GO:0045296]; FFAT motif binding [GO:0033149]; microtubule binding [GO:0008017]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] | 133111.259821095 | 0.259354352259895 | 0.0122947066996641 | 0.0556848986093501 |
| P19823 | P19823 | ITIH2_HUMAN | Inter-alpha-trypsin inhibitor heavy chain H2 (ITI heavy chain H2) (ITI-HC2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP) | ITIH2 | hyaluronan metabolic process [GO:0030212] | blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576] | endopeptidase inhibitor activity [GO:0004866]; hyaluronic acid binding [GO:0005540]; serine-type endopeptidase inhibitor activity [GO:0004867] | 19228.28331345025 | -0.352360208261521 | 0.0123216092666187 | 0.055762171010113 |
| Q9Y394 | Q9Y394 | DHRS7_HUMAN | Dehydrogenase/reductase SDR family member 7 (EC 1.1.1.-) (Retinal short-chain dehydrogenase/reductase 4) (retSDR4) (Short chain dehydrogenase/reductase family 34C member 1) (Protein SDR34C1) | DHRS7 | endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] | carbonyl reductase (NADPH) activity [GO:0004090]; NADP-retinol dehydrogenase activity [GO:0052650]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616] | 20499.5517966493 | -0.189847824611303 | 0.0123471189127763 | 0.0558054946527233 | |
| Q8NCL4 | Q8NCL4 | GALT6_HUMAN | Polypeptide N-acetylgalactosaminyltransferase 6 (EC 2.4.1.41) (Polypeptide GalNAc transferase 6) (GalNAc-T6) (pp-GaNTase 6) (Protein-UDP acetylgalactosaminyltransferase 6) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6) | GALNT6 | O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via threonine [GO:0018243] | Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471] | carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] | 2058.192680072275 | 2.82358872053846 | 0.0123508807438254 | 0.0558054946527233 |
| C9JLW8 | C9JLW8 | MCRI1_HUMAN | Mapk-regulated corepressor-interacting protein 1 (Granulin-2) (Protein FAM195B) | MCRIP1 | regulation of epithelial to mesenchymal transition [GO:0010717] | cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleus [GO:0005634] | 32960.04655468885 | 0.404851338400629 | 0.0124059925801997 | 0.0560098437923599 | |
| P46459 | P46459 | NSF_HUMAN | Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF) | NSF | exocytosis [GO:0006887]; Golgi to plasma membrane protein transport [GO:0043001]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; plasma membrane fusion [GO:0045026]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of receptor recycling [GO:0001921]; potassium ion transport [GO:0006813]; regulation of exocytosis [GO:0017157]; SNARE complex disassembly [GO:0035494]; vesicle-mediated transport [GO:0016192] | cytosol [GO:0005829]; dendritic shaft [GO:0043198]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein disaggregase activity [GO:0140545]; ionotropic glutamate receptor binding [GO:0035255]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; SNARE binding [GO:0000149]; syntaxin-1 binding [GO:0017075] | 36141.47118376435 | 0.0862083813111742 | 0.0124518803580368 | 0.0561722564559209 |
| Q8NFV4 | Q8NFV4 | ABHDB_HUMAN | sn-1-specific diacylglycerol lipase ABHD11 (EC 3.1.1.116) (Alpha/beta hydrolase domain-containing protein 11) (Abhydrolase domain-containing protein 11) (Williams-Beuren syndrome chromosomal region 21 protein) | ABHD11 | cellular lipid metabolic process [GO:0044255] | mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; oxoglutarate dehydrogenase complex [GO:0045252] | carboxylic ester hydrolase activity [GO:0052689]; lipase activity [GO:0016298] | 2662.591860340115 | 0.706285569707542 | 0.0124856635897566 | 0.0562351112079181 |
| P63208 | P63208 | SKP1_HUMAN | S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1) | SKP1 | chromatin remodeling [GO:0006338]; maintenance of protein location in nucleus [GO:0051457]; mitotic cell cycle [GO:0000278]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] | centrosome [GO:0005813]; Cul7-RING ubiquitin ligase complex [GO:0031467]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; SCF ubiquitin ligase complex [GO:0019005] | beta-catenin binding [GO:0008013]; cullin family protein binding [GO:0097602]; F-box domain binding [GO:1990444]; molecular function activator activity [GO:0140677]; protein domain specific binding [GO:0019904]; ubiquitin ligase complex scaffold activity [GO:0160072]; ubiquitin ligase-substrate adaptor activity [GO:1990756] | 43840.560422344905 | 0.30845968489907 | 0.012477437774879 | 0.0562351112079181 |
| Q9UDT6 | Q9UDT6 | CLIP2_HUMAN | CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) | CLIP2 | cytoplasmic microtubule organization [GO:0031122] | cell cortex [GO:0005938]; microtubule associated complex [GO:0005875]; microtubule plus-end [GO:0035371]; nucleus [GO:0005634] | microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010] | 12645.70539429235 | 0.199416906680814 | 0.0125219709924278 | 0.0563538424488452 |
| Q96GD0 | Q96GD0 | PLPP_HUMAN | Chronophin (EC 3.1.3.16) (EC 3.1.3.74) (Pyridoxal phosphate phosphatase) (PLP phosphatase) | PDXP | actin rod assembly [GO:0031247]; cellular response to ATP [GO:0071318]; dephosphorylation [GO:0016311]; positive regulation of actin filament depolymerization [GO:0030836]; protein dephosphorylation [GO:0006470]; pyridoxal phosphate catabolic process [GO:0032361]; regulation of cytokinesis [GO:0032465]; regulation of mitotic nuclear division [GO:0007088] | cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; lamellipodium membrane [GO:0031258]; ruffle membrane [GO:0032587] | heat shock protein binding [GO:0031072]; magnesium ion binding [GO:0000287]; myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]; protein homodimerization activity [GO:0042803]; pyridoxal phosphatase activity [GO:0033883] | 11810.3929994516 | -0.322291591472404 | 0.0125784224181282 | 0.0565181137360144 |
| P31943 | P31943 | HNRH1_HUMAN | Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] | HNRNPH1 | mRNA splicing, via spliceosome [GO:0000398]; regulation of RNA splicing [GO:0043484]; RNA processing [GO:0006396] | catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] | identical protein binding [GO:0042802]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723] | 70414.94704977665 | 0.119738199209063 | 0.0126918348953791 | 0.0569374002511625 |
| Q9BWD1 | Q9BWD1 | THIC_HUMAN | Acetyl-CoA acetyltransferase, cytosolic (EC 2.3.1.9) (Acetyl-CoA transferase-like protein) (Cytosolic acetoacetyl-CoA thiolase) | ACAT2 | ergosterol biosynthetic process [GO:0006696]; fatty acid beta-oxidation [GO:0006635]; lipid metabolic process [GO:0006629] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739] | acetyl-CoA C-acetyltransferase activity [GO:0003985] | 28329.4903722623 | -0.281093501883325 | 0.0127425008355773 | 0.0570922805182061 |
| Q92930 | Q92930 | RAB8B_HUMAN | Ras-related protein Rab-8B | RAB8B | antigen processing and presentation [GO:0019882]; cell-substrate junction organization [GO:0150115]; endocytic recycling [GO:0032456]; Golgi vesicle fusion to target membrane [GO:0048210]; positive regulation of cell projection organization [GO:0031346]; positive regulation of corticotropin secretion [GO:0051461]; protein import into peroxisome membrane [GO:0045046]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; regulation of exocytosis [GO:0017157]; vesicle docking involved in exocytosis [GO:0006904] | cell tip [GO:0051286]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal membrane [GO:0005778]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; synaptic vesicle [GO:0008021]; trans-Golgi network transport vesicle [GO:0030140] | GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; signaling receptor binding [GO:0005102]; TPR domain binding [GO:0030911] | 57333.84575618285 | 0.606897995673686 | 0.0127465116229316 | 0.0570922805182061 |
| P04181 | P04181 | OAT_HUMAN | Ornithine aminotransferase, mitochondrial (EC 2.6.1.13) (Ornithine delta-aminotransferase) (Ornithine--oxo-acid aminotransferase) [Cleaved into: Ornithine aminotransferase, hepatic form; Ornithine aminotransferase, renal form] | OAT | arginine catabolic process to glutamate [GO:0019544]; arginine catabolic process to proline via ornithine [GO:0010121]; L-proline biosynthetic process [GO:0055129]; visual perception [GO:0007601] | cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] | identical protein binding [GO:0042802]; ornithine aminotransferase activity [GO:0004587]; pyridoxal phosphate binding [GO:0030170] | 37644.51276084565 | 0.180417763510046 | 0.0128608818141604 | 0.0575455202957962 |
| P55081 | P55081 | MFAP1_HUMAN | Microfibrillar-associated protein 1 (Spliceosome B complex protein MFAP1) | MFAP1 | mRNA splicing, via spliceosome [GO:0000398] | centrosome [GO:0005813]; microfibril [GO:0001527]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684] | RNA binding [GO:0003723] | 6521.67412511347 | 0.375329035076675 | 0.0128953703260347 | 0.0576223724505618 |
| Q9H974 | Q9H974 | QTRT2_HUMAN | Queuine tRNA-ribosyltransferase accessory subunit 2 (Queuine tRNA-ribosyltransferase domain-containing protein 1) | QTRT2 | tRNA-guanine transglycosylation [GO:0101030] | cytoplasm [GO:0005737]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]; transferase complex [GO:1990234] | metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049]; tRNA-guanosine(34) queuine transglycosylase activity [GO:0008479] | 4628.028622113545 | 0.450110624616009 | 0.0129725283620295 | 0.0579214702121823 |
| Q8IZP0 | Q8IZP0 | ABI1_HUMAN | Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) | ABI1 | actin polymerization or depolymerization [GO:0008154]; dendrite morphogenesis [GO:0048813]; lamellipodium morphogenesis [GO:0072673]; megakaryocyte development [GO:0035855]; negative regulation of cell population proliferation [GO:0008285]; neuron migration [GO:0001764]; positive regulation of protein tyrosine kinase activity [GO:0061098]; somitogenesis [GO:0001756]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] | actin-based cell projection [GO:0098858]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; filopodium tip [GO:0032433]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; SCAR complex [GO:0031209] | cadherin binding [GO:0045296]; cytoskeletal protein binding [GO:0008092]; protein tyrosine kinase activator activity [GO:0030296]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591] | 32275.419281498704 | 0.235225668758689 | 0.0130018049535014 | 0.0580064778476684 |
| P18074 | P18074 | ERCC2_HUMAN | General transcription and DNA repair factor IIH helicase subunit XPD (TFIIH subunit XPD) (EC 3.6.4.12) (Basic transcription factor 2 80 kDa subunit) (BTF2 p80) (CXPD) (DNA excision repair protein ERCC-2) (DNA repair protein complementing XP-D cells) (TFIIH basal transcription factor complex 80 kDa subunit) (TFIIH 80 kDa subunit) (TFIIH p80) (Xeroderma pigmentosum group D-complementing protein) | ERCC2 | apoptotic process [GO:0006915]; bone mineralization [GO:0030282]; central nervous system myelin formation [GO:0032289]; chromosome segregation [GO:0007059]; determination of adult lifespan [GO:0008340]; embryonic cleavage [GO:0040016]; embryonic organ development [GO:0048568]; erythrocyte maturation [GO:0043249]; extracellular matrix organization [GO:0030198]; hair cell differentiation [GO:0035315]; hair follicle maturation [GO:0048820]; hematopoietic stem cell differentiation [GO:0060218]; hematopoietic stem cell proliferation [GO:0071425]; in utero embryonic development [GO:0001701]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; multicellular organism growth [GO:0035264]; nucleotide-excision repair [GO:0006289]; positive regulation of mitotic recombination [GO:0045951]; post-embryonic development [GO:0009791]; regulation of mitotic cell cycle phase transition [GO:1901990]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]; spinal cord development [GO:0021510]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase I [GO:0006362]; transcription initiation at RNA polymerase II promoter [GO:0006367]; transcription-coupled nucleotide-excision repair [GO:0006283]; UV protection [GO:0009650] | CAK-ERCC2 complex [GO:0070516]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; MMXD complex [GO:0071817]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675] | 4 iron, 4 sulfur cluster binding [GO:0051539]; 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; damaged DNA binding [GO:0003684]; DNA helicase activity [GO:0003678]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674] | 5845.57898580636 | -0.371414053320751 | 0.0131548152718559 | 0.0585048534775006 |
| Q14558 | Q14558 | KPRA_HUMAN | Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPP synthase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthase-associated protein) (PAP39) | PRPSAP1 | 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; nucleobase-containing compound metabolic process [GO:0006139]; purine nucleotide biosynthetic process [GO:0006164] | cytoplasm [GO:0005737]; ribose phosphate diphosphokinase complex [GO:0002189] | ATP binding [GO:0005524]; enzyme inhibitor activity [GO:0004857]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; ribose phosphate diphosphokinase activity [GO:0004749] | 12543.7389629576 | -0.345596104570492 | 0.0131541190628964 | 0.0585048534775006 |
| Q93008 | Q93008 | USP9X_HUMAN | Ubiquitin carboxyl-terminal hydrolase 9X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets in mammals) (hFAM) (Fat facets protein-related, X-linked) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X) | USP9X | amyloid fibril formation [GO:1990000]; axon extension [GO:0048675]; BMP signaling pathway [GO:0030509]; cell division [GO:0051301]; cell migration [GO:0016477]; chromosome segregation [GO:0007059]; cilium assembly [GO:0060271]; cytosolic ciliogenesis [GO:0061824]; DNA dealkylation involved in DNA repair [GO:0006307]; female gamete generation [GO:0007292]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; positive regulation of protein binding [GO:0032092]; positive regulation of TORC2 signaling [GO:1904515]; protein deubiquitination [GO:0016579]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein K63-linked deubiquitination [GO:0070536]; protein localization [GO:0008104]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511]; transforming growth factor beta receptor signaling pathway [GO:0007179] | centrosome [GO:0005813]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; membrane [GO:0016020]; nucleus [GO:0005634] | co-SMAD binding [GO:0070410]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; deubiquitinase activity [GO:0101005]; K11-linked deubiquitinase activity [GO:0180017]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]; molecular sequestering activity [GO:0140313] | 12132.727737556801 | -0.327161905914411 | 0.013178289337357 | 0.058563284223894 |
| Q13643 | Q13643 | FHL3_HUMAN | Four and a half LIM domains protein 3 (FHL-3) (Skeletal muscle LIM-protein 2) (SLIM-2) | FHL3 | actin cytoskeleton organization [GO:0030036]; muscle organ development [GO:0007517] | focal adhesion [GO:0005925]; nucleus [GO:0005634]; stress fiber [GO:0001725]; Z disc [GO:0030018] | actin binding [GO:0003779]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712] | 50528.34518103985 | -0.794434740814377 | 0.013443051593157 | 0.0596711591378072 |
| Q06830 | Q06830 | PRDX1_HUMAN | Peroxiredoxin-1 (EC 1.11.1.24) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1) | PRDX1 | canonical NF-kappaB signal transduction [GO:0007249]; cell population proliferation [GO:0008283]; cell redox homeostasis [GO:0045454]; erythrocyte homeostasis [GO:0034101]; fibroblast proliferation [GO:0048144]; hydrogen peroxide catabolic process [GO:0042744]; leukocyte activation [GO:0045321]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; regulation of stress-activated MAPK cascade [GO:0032872]; removal of superoxide radicals [GO:0019430]; response to oxidative stress [GO:0006979]; skeletal system development [GO:0001501] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; melanosome [GO:0042470]; nucleus [GO:0005634] | cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; peroxidase activity [GO:0004601]; RNA binding [GO:0003723]; thioredoxin peroxidase activity [GO:0008379] | 295850.002256886 | 0.199357192269824 | 0.0134486534096329 | 0.0596711591378072 |
| Q08174 | Q08174 | PCDH1_HUMAN | Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) | PCDH1 | cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] | cell junction [GO:0030054]; cell-cell junction [GO:0005911]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] | calcium ion binding [GO:0005509] | 5383.975275321235 | -0.85660483948874 | 0.0134800809842123 | 0.0597638019221805 |
| Q92621 | Q92621 | NU205_HUMAN | Nuclear pore complex protein Nup205 (205 kDa nucleoporin) (Nucleoporin Nup205) | NUP205 | mRNA transport [GO:0051028]; nuclear pore complex assembly [GO:0051292]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031] | cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore inner ring [GO:0044611] | structural constituent of nuclear pore [GO:0017056] | 7021.91728332821 | -0.334423425296669 | 0.0135156087065471 | 0.0598744635897542 |
| Q643R3 | Q643R3 | LPCT4_HUMAN | Lysophospholipid acyltransferase LPCAT4 (1-acylglycerol-3-phosphate O-acyltransferase 7) (1-AGP acyltransferase 7) (1-AGPAT 7) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) (1-acylglycerophosphoserine O-acyltransferase) (EC 2.3.1.n6) (1-alkenylglycerophosphoethanolamine O-acyltransferase) (EC 2.3.1.121) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acyltransferase-like 3) (Lysophosphatidylcholine acyltransferase 4) (Lysophosphatidylethanolamine acyltransferase 2) (EC 2.3.1.n7) (Plasmalogen synthase) | LPCAT4 | phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid metabolic process [GO:0006644] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] | 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-acylglycerophosphoethanolamine O-acyltransferase activity [GO:0106262]; 1-acylglycerophosphoserine O-acyltransferase activity [GO:0106263]; 1-alkenylglycerophosphoethanolamine O-acyltransferase activity [GO:0047166]; 1-alkylglycerophosphocholine O-acetyltransferase activity [GO:0047192]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; lysophosphatidic acid acyltransferase activity [GO:0042171]; lysophospholipid acyltransferase activity [GO:0071617] | 4441.102950963044 | 0.686959687994948 | 0.0135526427334408 | 0.0599916200997465 |
| Q9UM47 | Q9UM47 | NOTC3_HUMAN | Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] | NOTCH3 | artery morphogenesis [GO:0048844]; axon guidance [GO:0007411]; forebrain development [GO:0030900]; glomerular capillary formation [GO:0072104]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroblast differentiation [GO:0014016]; neuron fate commitment [GO:0048663]; Notch signaling pathway [GO:0007219]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944] | cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] | cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; Notch binding [GO:0005112]; signaling receptor activity [GO:0038023] | 2864.05577262963 | 0.305924236444717 | 0.0136527212979232 | 0.0603874464278167 |
| Q68D10 | Q68D10 | SPT2_HUMAN | Protein SPT2 homolog (Protein KU002155) (SPT2 domain-containing protein 1) | SPTY2D1 | heterochromatin formation [GO:0031507]; nucleosome assembly [GO:0006334]; regulation of DNA-templated transcription [GO:0006355]; transcription by RNA polymerase I [GO:0006360] | nucleolus [GO:0005730]; nucleoplasm [GO:0005654] | DNA binding [GO:0003677]; histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; RNA polymerase I core binding [GO:0001042] | 5468.600676442969 | 0.334195666892573 | 0.0137346695853422 | 0.0607025256400537 |
| Q9NSC5 | Q9NSC5 | HOME3_HUMAN | Homer protein homolog 3 (Homer-3) | HOMER3 | G protein-coupled glutamate receptor signaling pathway [GO:0007216]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of interleukin-2 production [GO:0032703]; protein targeting [GO:0006605]; regulation of store-operated calcium entry [GO:2001256] | basal part of cell [GO:0045178]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] | G protein-coupled glutamate receptor binding [GO:0035256]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904] | 16613.80327089845 | 0.311379580187097 | 0.013881759714238 | 0.0612570487078446 |
| P49321 | P49321 | NASP_HUMAN | Nuclear autoantigenic sperm protein (NASP) | NASP | blastocyst development [GO:0001824]; cell cycle [GO:0007049]; CENP-A containing chromatin assembly [GO:0034080]; DNA replication [GO:0006260]; DNA replication-dependent chromatin assembly [GO:0006335]; male gonad development [GO:0008584]; nucleosome assembly [GO:0006334]; protein transport [GO:0015031]; response to testosterone [GO:0033574] | chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] | histone binding [GO:0042393]; protein-containing complex binding [GO:0044877] | 9724.423780859825 | 0.227838316870125 | 0.013948008305881 | 0.0615014903199389 |
| P42574 | P42574 | CASP3_HUMAN | Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] | CASP3 | anterior neural tube closure [GO:0061713]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; axonal fasciculation [GO:0007413]; B cell homeostasis [GO:0001782]; cell fate commitment [GO:0045165]; cellular response to staurosporine [GO:0072734]; DNA damage response [GO:0006974]; epithelial cell apoptotic process [GO:1904019]; erythrocyte differentiation [GO:0030218]; execution phase of apoptosis [GO:0097194]; fibroblast apoptotic process [GO:0044346]; glial cell apoptotic process [GO:0034349]; heart development [GO:0007507]; hippocampus development [GO:0021766]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to osmotic stress [GO:0008627]; keratinocyte differentiation [GO:0030216]; learning or memory [GO:0007611]; leukocyte apoptotic process [GO:0071887]; luteolysis [GO:0001554]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of cell cycle [GO:0045786]; negative regulation of cytokine production [GO:0001818]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; neurotrophin TRK receptor signaling pathway [GO:0048011]; platelet formation [GO:0030220]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of pyroptosis [GO:0140639]; protein catabolic process [GO:0030163]; protein maturation [GO:0051604]; protein processing [GO:0016485]; proteolysis [GO:0006508]; pyroptosis [GO:0070269]; regulation of macroautophagy [GO:0016241]; regulation of protein stability [GO:0031647]; response to amino acid [GO:0043200]; response to cobalt ion [GO:0032025]; response to estradiol [GO:0032355]; response to glucocorticoid [GO:0051384]; response to glucose [GO:0009749]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]; response to tumor necrosis factor [GO:0034612]; response to UV [GO:0009411]; response to wounding [GO:0009611]; response to X-ray [GO:0010165]; response to xenobiotic stimulus [GO:0009410]; sensory perception of sound [GO:0007605]; striated muscle cell differentiation [GO:0051146]; T cell homeostasis [GO:0043029] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | aspartic-type endopeptidase activity [GO:0004190]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type endopeptidase activity involved in apoptotic process [GO:0097153]; cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097199]; cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:0097200]; death receptor binding [GO:0005123]; enzyme activator activity [GO:0008047]; peptidase activity [GO:0008233]; phospholipase A2 activator activity [GO:0016005]; protease binding [GO:0002020]; protein-containing complex binding [GO:0044877] | 14823.52343516465 | 0.380364124018229 | 0.0139767335624882 | 0.0615802273445241 |
| Q96A65 | Q96A65 | EXOC4_HUMAN | Exocyst complex component 4 (Exocyst complex component Sec8) | EXOC4 | chemical synaptic transmission [GO:0007268]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; paraxial mesoderm formation [GO:0048341]; protein transmembrane transport [GO:0071806]; regulation of macroautophagy [GO:0016241]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522] | centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; exocyst [GO:0000145]; Flemming body [GO:0090543]; growth cone membrane [GO:0032584]; membrane [GO:0016020]; microvillus [GO:0005902]; myelin sheath abaxonal region [GO:0035748]; plasma membrane [GO:0005886]; synapse [GO:0045202] | PDZ domain binding [GO:0030165] | 9737.366445306568 | -0.235124823024624 | 0.0140627259166938 | 0.0618628921148967 |
| P09914 | P09914 | IFIT1_HUMAN | Interferon-induced protein with tetratricopeptide repeats 1 (IFIT-1) (Interferon-induced 56 kDa protein) (IFI-56K) (P56) | IFIT1 | antiviral innate immune response [GO:0140374]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to type I interferon [GO:0071357]; defense response to virus [GO:0051607]; intracellular transport of viral protein in host cell [GO:0019060]; negative regulation of helicase activity [GO:0051097]; negative regulation of protein binding [GO:0032091]; negative regulation of viral genome replication [GO:0045071]; positive regulation of viral genome replication [GO:0045070]; response to virus [GO:0009615] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; host cell [GO:0043657] | RNA binding [GO:0003723] | 3139.8055409975 | -1.45172022803457 | 0.0140561950889837 | 0.0618628921148967 |
| P19367 | P19367 | HXK1_HUMAN | Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) (Hexokinase-A) | HK1 | canonical glycolysis [GO:0061621]; carbohydrate phosphorylation [GO:0046835]; establishment of protein localization to mitochondrion [GO:0072655]; fructose 6-phosphate metabolic process [GO:0006002]; glucose 6-phosphate metabolic process [GO:0051156]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intracellular glucose homeostasis [GO:0001678]; maintenance of protein location in mitochondrion [GO:0072656]; mannose metabolic process [GO:0006013]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of interleukin-1 beta production [GO:0032731] | cytosol [GO:0005829]; membrane raft [GO:0045121]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] | ATP binding [GO:0005524]; fructokinase activity [GO:0008865]; glucokinase activity [GO:0004340]; glucosamine kinase activity [GO:0047931]; glucose binding [GO:0005536]; hexokinase activity [GO:0004396]; mannokinase activity [GO:0019158]; peptidoglycan binding [GO:0042834] | 45858.76084634965 | -0.161859766233898 | 0.0141077754471964 | 0.0620129213993908 |
| Q8NBZ7 | Q8NBZ7 | UXS1_HUMAN | UDP-glucuronic acid decarboxylase 1 (EC 4.1.1.35) (UDP-glucuronate decarboxylase 1) (UGD) (UXS-1) (hUXS) (hUXS1) | UXS1 | D-xylose metabolic process [GO:0042732]; UDP-D-xylose biosynthetic process [GO:0033320] | catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi cisterna membrane [GO:0032580] | identical protein binding [GO:0042802]; NAD+ binding [GO:0070403]; protein homodimerization activity [GO:0042803]; UDP-glucuronate decarboxylase activity [GO:0048040] | 12277.95525919215 | 0.325378784138097 | 0.0142923181663599 | 0.062678231215631 |
| Q9UID3 | Q9UID3 | VPS51_HUMAN | Vacuolar protein sorting-associated protein 51 homolog (Another new gene 2 protein) (Protein fat-free homolog) | VPS51 | autophagy [GO:0006914]; brain morphogenesis [GO:0048854]; endocytic recycling [GO:0032456]; Golgi organization [GO:0007030]; Golgi vesicle transport [GO:0048193]; lysosomal transport [GO:0007041]; protein targeting [GO:0006605]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle-mediated cholesterol transport [GO:0090119] | cytosol [GO:0005829]; EARP complex [GO:1990745]; GARP complex [GO:0000938]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; recycling endosome [GO:0055037]; trans-Golgi network membrane [GO:0032588] | 6140.4264864140805 | -0.427223330566221 | 0.0143646488601614 | 0.0629467134119679 | |
| P15408 | P15408 | FOSL2_HUMAN | Fos-related antigen 2 (FRA-2) | FOSL2 | alveolar secondary septum development [GO:0061144]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; bone mineralization [GO:0030282]; cell death [GO:0008219]; cell morphogenesis [GO:0000902]; chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; collagen biosynthetic process [GO:0032964]; fat cell apoptotic process [GO:1904606]; fat cell differentiation [GO:0045444]; fat pad development [GO:0060613]; gene expression [GO:0010467]; glucose homeostasis [GO:0042593]; growth plate cartilage development [GO:0003417]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response to antigenic stimulus [GO:0002437]; innate immune response [GO:0045087]; insulin metabolic process [GO:1901142]; keratinocyte development [GO:0003334]; lung connective tissue development [GO:0060427]; macrophage differentiation [GO:0030225]; mucus secretion [GO:0070254]; multicellular organism growth [GO:0035264]; myofibroblast differentiation [GO:0036446]; neutrophil differentiation [GO:0030223]; NK T cell differentiation [GO:0001865]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of multicellular organism growth [GO:0040014]; regulation of myofibroblast differentiation [GO:1904760]; regulation of transcription by RNA polymerase II [GO:0006357]; response to bleomycin [GO:1904975]; response to glucocorticoid [GO:0051384]; response to Gram-positive bacterium [GO:0140459]; response to hypoxia [GO:0001666]; response to interleukin-13 [GO:0035962]; response to interleukin-7 [GO:0098760]; response to leukemia inhibitory factor [GO:1990823]; response to lipopolysaccharide [GO:0032496]; response to xenobiotic stimulus [GO:0009410]; smooth muscle tissue development [GO:0048745]; T cell receptor signaling pathway [GO:0050852]; tissue remodeling [GO:0048771] | chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] | chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977] | 15686.2472526042 | 0.395591679957164 | 0.0144226074774347 | 0.0631030841445134 |
| Q6ZWT7 | Q6ZWT7 | MBOA2_HUMAN | Lysophospholipid acyltransferase 2 (LPLAT 2) (EC 2.3.1.-) (1-acylglycerophosphate O-acyltransferase MBOAT2) (EC 2.3.1.51) (1-acylglycerophosphocholine O-acyltransferase MBOAT2) (EC 2.3.1.23) (1-acylglycerophosphoethanolamine MBOAT2 O-acyltransferase) (EC 2.3.1.n7) (Lysophosphatidic acid acyltransferase) (LPAAT) (Lyso-PA acyltransferase) (Lysophosphatidylcholine acyltransferase) (LPCAT) (Lyso-PC acyltransferase) (Lysophosphatidylcholine acyltransferase 4) (Lyso-PC acyltransferase 4) (Lysophosphatidylethanolamine acyltransferase) (LPEAT) (Lyso-PE acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 2) (O-acyltransferase domain-containing protein 2) | MBOAT2 | lipid modification [GO:0030258]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid biosynthetic process [GO:0008654]; regulation of chondrocyte differentiation [GO:0032330] | endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] | 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-acylglycerophosphoethanolamine O-acyltransferase activity [GO:0106262]; 1-acylglycerophosphoserine O-acyltransferase activity [GO:0106263]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; acyltransferase activity [GO:0016746] | 2761.68942261544 | -1.08864489442832 | 0.0144201613511924 | 0.0631030841445134 |
| Q8N3D4 | Q8N3D4 | EH1L1_HUMAN | EH domain-binding protein 1-like protein 1 | EHBP1L1 | actin cytoskeleton organization [GO:0030036] | endosome [GO:0005768]; filamentous actin [GO:0031941]; membrane [GO:0016020]; microtubule organizing center [GO:0005815] | 8815.946623447086 | 0.247788788449396 | 0.0145272330012046 | 0.0635118072413777 | |
| Q9P1F3 | Q9P1F3 | ABRAL_HUMAN | Costars family protein ABRACL (ABRA C-terminal-like protein) | ABRACL | regulation of actin filament-based process [GO:0032970] | 28657.17626735985 | -0.588443750390942 | 0.0146282475351173 | 0.0638997498638875 | ||
| P50570 | P50570 | DYN2_HUMAN | Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II) | DNM2 | actin filament bundle organization [GO:0061572]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; autophagy [GO:0006914]; centrosome cycle [GO:0007098]; endocytosis [GO:0006897]; G2/M transition of mitotic cell cycle [GO:0000086]; membrane organization [GO:0061024]; membrane tubulation [GO:0097749]; negative regulation of membrane tubulation [GO:1903526]; neuron projection morphogenesis [GO:0048812]; phagocytosis [GO:0006909]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; post-Golgi vesicle-mediated transport [GO:0006892]; protein polymerization [GO:0051258]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of axon extension [GO:0030516]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165]; stress fiber assembly [GO:0043149]; synaptic vesicle budding from presynaptic endocytic zone membrane [GO:0016185]; synaptic vesicle transport [GO:0048489]; transferrin transport [GO:0033572]; vesicle scission [GO:0099050] | centriole [GO:0005814]; centrosome [GO:0005813]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; microtubule [GO:0005874]; midbody [GO:0030496]; neuron projection [GO:0043005]; phagocytic cup [GO:0001891]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; podosome [GO:0002102]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; recycling endosome [GO:0055037]; synapse [GO:0045202]; uropod [GO:0001931] | enzyme binding [GO:0019899]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein self-association [GO:0043621]; SH3 domain binding [GO:0017124] | 28896.911165758902 | -0.145821331377158 | 0.0146385237069054 | 0.0638997498638875 |
| Q7Z4W1 | Q7Z4W1 | DCXR_HUMAN | L-xylulose reductase (XR) (EC 1.1.1.10) (Carbonyl reductase II) (Dicarbonyl/L-xylulose reductase) (Kidney dicarbonyl reductase) (kiDCR) (Short chain dehydrogenase/reductase family 20C member 1) (Sperm surface protein P34H) | DCXR | D-xylose metabolic process [GO:0042732]; glucose metabolic process [GO:0006006]; glucuronate catabolic process to xylulose 5-phosphate [GO:0019640]; NADP metabolic process [GO:0006739]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; xylulose metabolic process [GO:0005997] | brush border [GO:0005903]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microvillus [GO:0005902]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | carbonyl reductase (NADPH) activity [GO:0004090]; identical protein binding [GO:0042802]; L-xylulose reductase (NADP+) activity [GO:0050038]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655] | 3721.057970068935 | -0.656728601337105 | 0.0146898510380013 | 0.0640744387846923 |
| P35240 | P35240 | MERL_HUMAN | Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin) | NF2 | actin cytoskeleton organization [GO:0030036]; cell-cell junction organization [GO:0045216]; ectoderm development [GO:0007398]; hippocampus development [GO:0021766]; lens fiber cell differentiation [GO:0070306]; MAPK cascade [GO:0000165]; mesoderm formation [GO:0001707]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of Schwann cell proliferation [GO:0010626]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast proliferation [GO:0033687]; positive regulation of cell differentiation [GO:0045597]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of stress fiber assembly [GO:0051496]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell shape [GO:0008360]; regulation of gliogenesis [GO:0014013]; regulation of hippo signaling [GO:0035330]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of organelle assembly [GO:1902115]; regulation of protein localization to nucleus [GO:1900180]; regulation of protein stability [GO:0031647]; regulation of stem cell proliferation [GO:0072091]; Schwann cell proliferation [GO:0014010] | adherens junction [GO:0005912]; apical part of cell [GO:0045177]; cell body [GO:0044297]; cleavage furrow [GO:0032154]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; filopodium [GO:0030175]; filopodium membrane [GO:0031527]; lamellipodium [GO:0030027]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] | actin binding [GO:0003779]; integrin binding [GO:0005178] | 6870.386767157061 | -0.396658155066206 | 0.0147985706363019 | 0.0644990009425279 |
| P23510 | P23510 | TNFL4_HUMAN | Tumor necrosis factor ligand superfamily member 4 (Glycoprotein Gp34) (OX40 ligand) (OX40L) (TAX transcriptionally-activated glycoprotein 1) (CD antigen CD252) | TNFSF4 | acute inflammatory response [GO:0002526]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to prostaglandin E stimulus [GO:0071380]; defense response to nematode [GO:0002215]; immune response [GO:0006955]; inflammatory response [GO:0006954]; memory T cell activation [GO:0035709]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of regulatory T cell differentiation [GO:0045590]; negative regulation of T-helper 1 cell differentiation [GO:0045626]; negative regulation of type II interferon production [GO:0032689]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of B cell activation [GO:0050871]; positive regulation of CD4-positive, alpha-beta T cell costimulation [GO:1900281]; positive regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043372]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production [GO:0001819]; positive regulation of immunoglobulin mediated immune response [GO:0002891]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-4-dependent isotype switching to IgE isotypes [GO:2000572]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; positive regulation of type 2 immune response [GO:0002830]; positive regulation of type II interferon production [GO:0032729]; regulation of adaptive immune response [GO:0002819]; regulation of inflammatory response [GO:0050727]; response to nitrogen dioxide [GO:0035713]; response to virus [GO:0009615]; signal transduction [GO:0007165]; T-helper 2 cell activation [GO:0035712] | cell surface [GO:0009986]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] | cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; tumor necrosis factor receptor superfamily binding [GO:0032813] | 32894.05012187275 | -0.346904350153589 | 0.0148697176885891 | 0.0647592778044164 |
| Q96H20 | Q96H20 | SNF8_HUMAN | Vacuolar-sorting protein SNF8 (ELL-associated protein of 30 kDa) (ESCRT-II complex subunit VPS22) (hVps22) | SNF8 | early endosome to late endosome transport [GO:0045022]; endocytic recycling [GO:0032456]; localization [GO:0051179]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of gene expression [GO:0010628]; positive regulation of protein catabolic process [GO:0045732]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; regulation of protein catabolic process [GO:0042176]; regulation of protein complex stability [GO:0061635]; regulation of transcription by RNA polymerase II [GO:0006357] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT II complex [GO:0000814]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; transcription regulator complex [GO:0005667] | channel regulator activity [GO:0016247]; lipid binding [GO:0008289]; protein homodimerization activity [GO:0042803] | 9633.931994619596 | -0.201383126522646 | 0.0149349435662085 | 0.0649933872858199 |
| Q9H9H4 | Q9H9H4 | VP37B_HUMAN | Vacuolar protein sorting-associated protein 37B (hVps37B) (ESCRT-I complex subunit VPS37B) | VPS37B | macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; positive regulation of viral budding via host ESCRT complex [GO:1903774]; protein targeting to membrane [GO:0006612]; protein targeting to vacuole [GO:0006623]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076] | cytoplasm [GO:0005737]; endosome [GO:0005768]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; midbody [GO:0030496]; plasma membrane [GO:0005886] | calcium-dependent protein binding [GO:0048306] | 4532.60758931581 | -4.22538234440551 | 0.0150140200492823 | 0.0652873657707086 |
| O43747 | O43747 | AP1G1_HUMAN | AP-1 complex subunit gamma-1 (Adaptor protein complex AP-1 subunit gamma-1) (Adaptor-related protein complex 1 subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain) (Gamma1-adaptin) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) | AP1G1 | basolateral protein secretion [GO:0110010]; endosome to melanosome transport [GO:0035646]; Golgi to lysosome transport [GO:0090160]; Golgi to vacuole transport [GO:0006896]; intracellular protein transport [GO:0006886]; melanosome assembly [GO:1903232]; melanosome organization [GO:0032438]; platelet dense granule organization [GO:0060155]; positive regulation of natural killer cell degranulation [GO:0043323]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; synaptic vesicle budding from endosome [GO:0016182]; synaptic vesicle endocytosis [GO:0048488]; vesicle-mediated transport [GO:0016192] | AP-1 adaptor complex [GO:0030121]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; presynapse [GO:0098793]; recycling endosome [GO:0055037]; trans-Golgi network membrane [GO:0032588] | clathrin adaptor activity [GO:0035615]; collagen binding [GO:0005518]; GTP-dependent protein binding [GO:0030742]; kinesin binding [GO:0019894]; small GTPase binding [GO:0031267] | 20113.765317392 | -0.23382456875942 | 0.0150402906838857 | 0.0653514470973134 |
| P82664 | P82664 | RT10_HUMAN | Small ribosomal subunit protein uS10m (28S ribosomal protein S10, mitochondrial) (MRP-S10) (S10mt) | MRPS10 | mitochondrial translation [GO:0032543] | mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] | 10509.650896785151 | 0.469278587678767 | 0.0150547635757381 | 0.0653642072184921 | |
| P14174 | P14174 | MIF_HUMAN | Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Glycosylation-inhibiting factor) (GIF) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) | MIF | carboxylic acid metabolic process [GO:0019752]; cell surface receptor signaling pathway [GO:0007166]; cellular senescence [GO:0090398]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell migration [GO:0030336]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of gene expression [GO:0010629]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of macrophage chemotaxis [GO:0010760]; negative regulation of mature B cell apoptotic process [GO:0002906]; negative regulation of myeloid cell apoptotic process [GO:0033033]; negative regulation of protein metabolic process [GO:0051248]; positive regulation of arachidonic acid secretion [GO:0090238]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of cytokine production [GO:0001819]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of myeloid leukocyte cytokine production involved in immune response [GO:0061081]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphorylation [GO:0042327]; positive regulation of prostaglandin secretion involved in immune response [GO:0061078]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of tumor necrosis factor production [GO:0032760]; prostaglandin biosynthetic process [GO:0001516]; protein homotrimerization [GO:0070207]; regulation of macrophage activation [GO:0043030] | cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]; vesicle [GO:0031982] | chemoattractant activity [GO:0042056]; cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; dopachrome isomerase activity [GO:0004167]; identical protein binding [GO:0042802]; phenylpyruvate tautomerase activity [GO:0050178]; protease binding [GO:0002020] | 615732.66235488 | -0.318685924557316 | 0.0151022104134428 | 0.0655200032178918 |
| P49591 | P49591 | SYSC_HUMAN | Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) | SARS1 | cytoplasmic translation [GO:0002181]; mitochondrial seryl-tRNA aminoacylation [GO:0070158]; negative regulation of angiogenesis [GO:0016525]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular endothelial growth factor production [GO:1904046]; selenocysteine incorporation [GO:0001514]; seryl-tRNA aminoacylation [GO:0006434]; translation [GO:0006412]; tRNA modification [GO:0006400] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleus [GO:0005634] | ATP binding [GO:0005524]; enzyme binding [GO:0019899]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; selenocysteine-tRNA ligase activity [GO:0098619]; serine-tRNA ligase activity [GO:0004828]; tRNA binding [GO:0000049] | 30488.41897773915 | -0.253673228392217 | 0.0152102347506533 | 0.0658877600131511 |
| O75817 | O75817 | POP7_HUMAN | Ribonuclease P protein subunit p20 (RNaseP protein p20) (Ribonucleases P/MRP protein subunit POP7 homolog) (hPOP7) | POP7 | rRNA processing [GO:0006364]; tRNA 5'-leader removal [GO:0001682]; tRNA processing [GO:0008033] | cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonuclease MRP complex [GO:0000172] | ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]; RNA binding [GO:0003723] | 9962.083859873033 | -1.19704179720716 | 0.0152538702820508 | 0.0660263017708935 |
| Q9NX55 | Q9NX55 | HYPK_HUMAN | Huntingtin-interacting protein K (Huntingtin yeast partner K) | HYPK | negative regulation of apoptotic process [GO:0043066]; protein stabilization [GO:0050821] | cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] | protein folding chaperone [GO:0044183] | 9770.490415053475 | 0.556372334558286 | 0.0153499490294267 | 0.0663914589318562 |
| O60869 | O60869 | EDF1_HUMAN | Endothelial differentiation-related factor 1 (EDF-1) (Multiprotein-bridging factor 1) (MBF1) | EDF1 | endothelial cell differentiation [GO:0045446]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of lipid metabolic process [GO:0019216] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | calmodulin binding [GO:0005516]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; TFIID-class transcription factor complex binding [GO:0001094]; transcription coactivator activity [GO:0003713] | 126880.52527177401 | 0.486741993905218 | 0.015396706991344 | 0.066542899933604 |
| P0CG30 | P0CG30 | GSTT2_HUMAN | Glutathione S-transferase theta-2B (EC 2.5.1.18) (Glutathione S-transferase theta-2) (GST class-theta-2) | GSTT2B | glutathione metabolic process [GO:0006749] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] | glutathione transferase activity [GO:0004364] | 11250.92095888215 | -1.4562780790634 | 0.0154367445653091 | 0.0666650874291475 |
| Q99961 | Q99961 | SH3G1_HUMAN | Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1) | SH3GL1 | central nervous system development [GO:0007417]; signal transduction [GO:0007165]; synaptic vesicle uncoating [GO:0016191] | anchoring junction [GO:0070161]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; glutamatergic synapse [GO:0098978]; podosome [GO:0002102]; presynapse [GO:0098793] | cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; lipid binding [GO:0008289] | 73384.33160776069 | 0.151784707199683 | 0.0155103073182246 | 0.0669317602932678 |
| Q9UL01 | Q9UL01 | DSE_HUMAN | Dermatan-sulfate epimerase (DS epimerase) (EC 5.1.3.19) (Chondroitin-glucuronate 5-epimerase) (Squamous cell carcinoma antigen recognized by T-cells 2) (SART-2) | DSE | chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate metabolic process [GO:0030204]; dermatan sulfate biosynthetic process [GO:0030208]; dermatan sulfate metabolic process [GO:0030205]; heparan sulfate proteoglycan biosynthetic process [GO:0015012] | cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] | chondroitin-glucuronate 5-epimerase activity [GO:0047757]; metal ion binding [GO:0046872] | 2231.424452549325 | -1.14510501573084 | 0.0157047791774307 | 0.0677193902734568 |
| Q96IX5 | Q96IX5 | ATPMK_HUMAN | ATP synthase membrane subunit K, mitochondrial (ATP synthase membrane subunit DAPIT, mitochondrial) (Diabetes-associated protein in insulin-sensitive tissues) (HCV F-transactivated protein 2) (Up-regulated during skeletal muscle growth protein 5) | ATP5MK | proton motive force-driven ATP synthesis [GO:0015986] | mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrion [GO:0005739] | 26374.61901103465 | -0.903249892063496 | 0.0157769106729058 | 0.0679786888765659 | |
| O00330 | O00330 | ODPX_HUMAN | Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX) | PDHX | acetyl-CoA biosynthetic process from pyruvate [GO:0006086] | mitochondrial matrix [GO:0005759]; mitochondrial pyruvate dehydrogenase complex [GO:0005967]; mitochondrion [GO:0005739]; pyruvate dehydrogenase complex [GO:0045254] | acyltransferase activity [GO:0016746] | 9320.387786644511 | 0.23788115581066 | 0.0159027441025932 | 0.0684688055359371 |
| Q9H5X1 | Q9H5X1 | CIA2A_HUMAN | Cytosolic iron-sulfur assembly component 2A (MIP18 family protein FAM96A) | CIAO2A | chromosome segregation [GO:0007059]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by [4Fe-4S] cluster transfer [GO:0106035]; protein maturation by iron-sulfur cluster transfer [GO:0097428] | CIA complex [GO:0097361]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] | metal ion binding [GO:0046872] | 10944.08106542355 | -0.385112944780322 | 0.015979309024061 | 0.0686940553340894 |
| P14927 | P14927 | QCR7_HUMAN | Cytochrome b-c1 complex subunit 7 (Complex III subunit 7) (Complex III subunit VII) (QP-C) (Ubiquinol-cytochrome c reductase complex 14 kDa protein) | UQCRB | aerobic respiration [GO:0009060]; cellular respiration [GO:0045333]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; oxidative phosphorylation [GO:0006119] | mitochondrial inner membrane [GO:0005743]; mitochondrial respirasome [GO:0005746]; mitochondrial respiratory chain complex III [GO:0005750] | 63683.93924490335 | 0.44197765938235 | 0.0163835968397211 | 0.0703786654236995 | |
| P28288 | P28288 | ABCD3_HUMAN | ATP-binding cassette sub-family D member 3 (EC 3.1.2.-) (EC 7.6.2.-) (70 kDa peroxisomal membrane protein) (PMP70) | ABCD3 | bile acid and bile salt transport [GO:0015721]; bile acid biosynthetic process [GO:0006699]; fatty acid beta-oxidation [GO:0006635]; fatty acid biosynthetic process [GO:0006633]; long-chain fatty acid import into peroxisome [GO:0015910]; peroxisome organization [GO:0007031]; phytanic acid metabolic process [GO:1903512]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410]; very long-chain fatty acid catabolic process [GO:0042760]; very long-chain fatty acid metabolic process [GO:0000038] | cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] | ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; fatty acyl-CoA hydrolase activity [GO:0047617]; long-chain fatty acid transporter activity [GO:0005324]; protein homodimerization activity [GO:0042803]; protein self-association [GO:0043621] | 11385.4094006302 | -0.225524002292971 | 0.0164401133371508 | 0.0704079230297024 |
| Q9Y3C1 | Q9Y3C1 | NOP16_HUMAN | Nucleolar protein 16 (HBV pre-S2 trans-regulated protein 3) | NOP16 | ribosomal large subunit biogenesis [GO:0042273] | intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] | RNA binding [GO:0003723] | 24918.847911430348 | 0.369679974288065 | 0.0164033235491908 | 0.0704079230297024 |
| P61925 | P61925 | IPKA_HUMAN | cAMP-dependent protein kinase inhibitor alpha (PKI-alpha) (cAMP-dependent protein kinase inhibitor, muscle/brain isoform) | PKIA | negative regulation of cAMP-dependent protein kinase activity [GO:2000480]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of G2/M transition of mitotic cell cycle [GO:0010389] | cytoplasm [GO:0005737]; nucleus [GO:0005634] | cAMP-dependent protein kinase inhibitor activity [GO:0004862]; protein kinase A catalytic subunit binding [GO:0034236] | 4632.272340814296 | 0.816629519070442 | 0.0164238238141936 | 0.0704079230297024 |
| Q14165 | Q14165 | MLEC_HUMAN | Malectin | MLEC | protein N-linked glycosylation [GO:0006487] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] | carbohydrate binding [GO:0030246]; enzyme binding [GO:0019899] | 53502.2901473846 | 0.340672381790125 | 0.0164831236063817 | 0.0705384714225683 |
| P51159 | P51159 | RB27A_HUMAN | Ras-related protein Rab-27A (Rab-27) (EC 3.6.5.2) (GTP-binding protein Ram) | RAB27A | antigen processing and presentation [GO:0019882]; blood coagulation [GO:0007596]; complement-dependent cytotoxicity [GO:0097278]; cytotoxic T cell degranulation [GO:0043316]; exocytosis [GO:0006887]; exosomal secretion [GO:1990182]; melanocyte differentiation [GO:0030318]; melanosome localization [GO:0032400]; melanosome transport [GO:0032402]; multivesicular body organization [GO:0036257]; multivesicular body sorting pathway [GO:0071985]; natural killer cell degranulation [GO:0043320]; positive regulation of constitutive secretory pathway [GO:1903435]; positive regulation of exocytosis [GO:0045921]; positive regulation of gene expression [GO:0010628]; positive regulation of phagocytosis [GO:0050766]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of regulated secretory pathway [GO:1903307]; protein secretion [GO:0009306]; synaptic vesicle transport [GO:0048489] | apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; dendrite [GO:0030425]; exocytic vesicle [GO:0070382]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; lysosome [GO:0005764]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; multivesicular body membrane [GO:0032585]; photoreceptor outer segment [GO:0001750]; secretory granule [GO:0030141]; specific granule lumen [GO:0035580]; Weibel-Palade body [GO:0033093] | G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; protein domain specific binding [GO:0019904] | 18500.40938208685 | 0.483509383308473 | 0.0164954949938057 | 0.0705384714225683 |
| Q9NWT6 | Q9NWT6 | HIF1N_HUMAN | Hypoxia-inducible factor 1-alpha inhibitor (EC 1.14.11.30) (EC 1.14.11.n4) (Factor inhibiting HIF-1) (FIH-1) (Hypoxia-inducible factor asparagine hydroxylase) | HIF1AN | negative regulation of Notch signaling pathway [GO:0045746]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of vasculogenesis [GO:2001214] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471] | [protein]-asparagine 3-dioxygenase activity [GO:0036140]; ankyrin repeat binding [GO:0071532]; carboxylic acid binding [GO:0031406]; ferrous iron binding [GO:0008198]; NF-kappaB binding [GO:0051059]; Notch binding [GO:0005112]; oxygen sensor activity [GO:0019826]; peptidyl-aspartic acid 3-dioxygenase activity [GO:0062101]; peptidyl-histidine dioxygenase activity [GO:0036139]; protein homodimerization activity [GO:0042803]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270] | 12266.12682934025 | 0.210037731165019 | 0.016528380531727 | 0.0706257949417536 |
| P55084 | P55084 | ECHB_HUMAN | Trifunctional enzyme subunit beta, mitochondrial (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.155) (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)] | HADHB | cellular response to lipopolysaccharide [GO:0071222]; fatty acid beta-oxidation [GO:0006635]; gene expression [GO:0010467] | cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrial envelope [GO:0005740]; mitochondrial fatty acid beta-oxidation multienzyme complex [GO:0016507]; mitochondrial inner membrane [GO:0005743]; mitochondrial nucleoid [GO:0042645]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] | 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; acetyl-CoA C-acetyltransferase activity [GO:0003985]; acetyl-CoA C-acyltransferase activity [GO:0003988]; acetyl-CoA C-myristoyltransferase activity [GO:0050633]; enoyl-CoA hydratase activity [GO:0004300]; lncRNA binding [GO:0106222]; RNA binding [GO:0003723] | 71088.5943628511 | 0.178996505443406 | 0.0167058541714739 | 0.0713303464473031 |
| Q7LBR1 | Q7LBR1 | CHM1B_HUMAN | Charged multivesicular body protein 1b (CHMP1.5) (Chromatin-modifying protein 1b) (CHMP1b) (Vacuolar protein sorting-associated protein 46-2) (Vps46-2) (hVps46-2) | CHMP1B | autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cell division [GO:0051301]; endosome transport via multivesicular body sorting pathway [GO:0032509]; ESCRT III complex disassembly [GO:1904903]; establishment of protein localization [GO:0045184]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702] | amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; membrane coat [GO:0030117]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] | identical protein binding [GO:0042802]; MIT domain binding [GO:0090541]; protein domain specific binding [GO:0019904] | 16296.015124808 | 0.417888735612534 | 0.0167230354808022 | 0.0713499390317961 |
| Q15345 | Q15345 | LRC41_HUMAN | Leucine-rich repeat-containing protein 41 (Protein Muf1) | LRRC41 | protein ubiquitination [GO:0016567] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634] | identical protein binding [GO:0042802] | 2707.81074032066 | -0.519359717855532 | 0.0169226752056294 | 0.0720931411391701 |
| Q13501 | Q13501 | SQSTM_HUMAN | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) | SQSTM1 | aggrephagy [GO:0035973]; apoptotic process [GO:0006915]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; brown fat cell proliferation [GO:0070342]; cell differentiation [GO:0030154]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; energy homeostasis [GO:0097009]; immune system process [GO:0002376]; intracellular signal transduction [GO:0035556]; macroautophagy [GO:0016236]; mitophagy [GO:0000423]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of transcription by RNA polymerase II [GO:0000122]; non-membrane-bounded organelle assembly [GO:0140694]; pexophagy [GO:0000425]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein catabolic process [GO:0030163]; protein import into nucleus [GO:0006606]; protein localization [GO:0008104]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein targeting to vacuole involved in autophagy [GO:0071211]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of mitochondrion organization [GO:0010821]; regulation of protein complex stability [GO:0061635]; regulation of Ras protein signal transduction [GO:0046578]; response to ischemia [GO:0002931]; response to mitochondrial depolarisation [GO:0098780]; temperature homeostasis [GO:0001659]; transcription by RNA polymerase II [GO:0006366]; ubiquitin-dependent protein catabolic process [GO:0006511] | aggresome [GO:0016235]; amphisome [GO:0044753]; autolysosome [GO:0044754]; autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; inclusion body [GO:0016234]; intracellular membrane-bounded organelle [GO:0043231]; intracellular non-membrane-bounded organelle [GO:0043232]; late endosome [GO:0005770]; Lewy body [GO:0097413]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; phagophore assembly site [GO:0000407]; PML body [GO:0016605]; sarcomere [GO:0030017]; sperm midpiece [GO:0097225] | enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; ionotropic glutamate receptor binding [GO:0035255]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; molecular condensate scaffold activity [GO:0140693]; molecular sequestering activity [GO:0140313]; protein kinase binding [GO:0019901]; protein kinase C binding [GO:0005080]; protein sequestering activity [GO:0140311]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; receptor tyrosine kinase binding [GO:0030971]; SH2 domain binding [GO:0042169]; signaling adaptor activity [GO:0035591]; signaling receptor activity [GO:0038023]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-dependent protein binding [GO:0140036]; zinc ion binding [GO:0008270] | 34260.3236081941 | 0.307438633418116 | 0.016912938316544 | 0.0720931411391701 |
| Q9UBM7 | Q9UBM7 | DHCR7_HUMAN | 7-dehydrocholesterol reductase (7-DHC reductase) (EC 1.3.1.21) (Delta7-sterol reductase) (Sterol Delta(7)-reductase) (Sterol reductase SR-2) | DHCR7 | brassinosteroid biosynthetic process [GO:0016132]; cholesterol biosynthetic process [GO:0006695]; cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear outer membrane [GO:0005640] | 7-dehydrocholesterol reductase activity [GO:0047598]; NADP binding [GO:0050661] | 71079.6042879037 | -0.26550532488062 | 0.0171204135843171 | 0.0728807388194894 |
| Q9H8S9 | Q9H8S9 | MOB1A_HUMAN | MOB kinase activator 1A (Mob1 alpha) (Mob1A) (Mob1 homolog 1B) (Mps one binder kinase activator-like 1B) | MOB1A | hippo signaling [GO:0035329]; positive regulation of protein phosphorylation [GO:0001934] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] | metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295] | 11645.60899348505 | 0.360863897261515 | 0.0171431361347173 | 0.0729226796841654 |
| Q86VR2 | Q86VR2 | RETR3_HUMAN | Reticulophagy regulator 3 | RETREG3 | collagen catabolic process [GO:0030574]; endoplasmic reticulum tubular network organization [GO:0071786]; positive regulation of neuron projection development [GO:0010976]; reticulophagy [GO:0061709] | endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; protein-containing complex [GO:0032991] | endoplasmic reticulum-autophagosome adaptor activity [GO:0140506] | 18960.280616496 | -0.200586882364625 | 0.0174336199147363 | 0.074102693501047 |
| Q9NQ30 | Q9NQ30 | ESM1_HUMAN | Endothelial cell-specific molecule 1 (ESM-1) | ESM1 | angiogenesis [GO:0001525]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of hepatocyte growth factor receptor signaling pathway [GO:1902204]; sprouting angiogenesis [GO:0002040] | extracellular region [GO:0005576] | hepatocyte growth factor receptor binding [GO:0005171]; integrin binding [GO:0005178] | 4855.151425391105 | 2.53328944781534 | 0.0174952215217088 | 0.0743087894617704 |
| Q8TBA6 | Q8TBA6 | GOGA5_HUMAN | Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) | GOLGA5 | Golgi organization [GO:0007030]; Golgi vesicle transport [GO:0048193]; retrograde transport, vesicle recycling within Golgi [GO:0000301] | cis-Golgi network [GO:0005801]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; transport vesicle [GO:0030133] | protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267] | 22431.733829179648 | 0.215590305563667 | 0.0175685230633699 | 0.0745642334659579 |
| Q9NZZ3 | Q9NZZ3 | CHMP5_HUMAN | Charged multivesicular body protein 5 (Chromatin-modifying protein 5) (SNF7 domain-containing protein 2) (Vacuolar protein sorting-associated protein 60) (Vps60) (hVps60) | CHMP5 | autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to muramyl dipeptide [GO:0071225]; erythrocyte differentiation [GO:0030218]; ESCRT III complex disassembly [GO:1904903]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; regulation of receptor recycling [GO:0001919]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle budding from membrane [GO:0006900]; vesicle fusion with vacuole [GO:0051469]; viral budding [GO:0046755]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702] | amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886] | cadherin binding [GO:0045296] | 30353.3109922642 | 0.549684733436289 | 0.0176708545563606 | 0.0749424116140262 |
| Q8TB96 | Q8TB96 | TIP_HUMAN | T-cell immunomodulatory protein (Protein TIP) (Integrin-alpha FG-GAP repeat-containing protein 1) (Linkin) | ITFG1 | extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] | 6975.134849790915 | 0.470665554846129 | 0.0177626467077693 | 0.0752753599448174 | ||
| Q969M7 | Q969M7 | UBE2F_HUMAN | NEDD8-conjugating enzyme UBE2F (EC 2.3.2.32) (NEDD8 carrier protein UBE2F) (NEDD8 protein ligase UBE2F) (NEDD8-conjugating enzyme 2) (RING-type E3 NEDD8 transferase UBE2F) (Ubiquitin-conjugating enzyme E2 F) | UBE2F | post-translational protein modification [GO:0043687]; protein neddylation [GO:0045116] | cytosol [GO:0005829]; nucleus [GO:0005634] | ATP binding [GO:0005524]; NEDD8 conjugating enzyme activity [GO:0061654]; NEDD8 ligase activity [GO:0061663]; NEDD8 transferase activity [GO:0019788] | 23669.220470674947 | 0.321299277717846 | 0.0178822951598634 | 0.0757257730760733 |
| Q9UJX6 | Q9UJX6 | ANC2_HUMAN | Anaphase-promoting complex subunit 2 (APC2) (Cyclosome subunit 2) | ANAPC2 | anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell differentiation [GO:0030154]; cell division [GO:0051301]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; negative regulation of gene expression [GO:0010629]; nervous system development [GO:0007399]; positive regulation of axon extension [GO:0045773]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic plasticity [GO:0031915]; protein K11-linked ubiquitination [GO:0070979]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346] | anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] | ubiquitin protein ligase binding [GO:0031625] | 5626.65710955572 | -0.669899009413004 | 0.0179006404968376 | 0.0757468476886348 |
| E9PAV3;Q13765 | E9PAV3 | NACAM_HUMAN | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | NACA | protein targeting to membrane [GO:0006612] | cytoplasm [GO:0005737]; nascent polypeptide-associated complex [GO:0005854]; nucleus [GO:0005634] | DNA binding [GO:0003677]; unfolded protein binding [GO:0051082] | 420837.03882729553 | 0.332771528510376 | 0.017925625489516 | 0.0757959656892521 |
| Q96TA1 | Q96TA1 | NIBA2_HUMAN | Protein Niban 2 (Meg-3) (Melanoma invasion by ERK) (MINERVA) (Niban-like protein 1) (Protein FAM129B) | NIBAN2 | axon guidance [GO:0007411]; cell differentiation [GO:0030154]; gonadotropin secretion [GO:0032274]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of embryonic development [GO:0040019]; positive regulation of gene expression via CpG island demethylation [GO:0044029]; positive regulation of skeletal muscle fiber development [GO:0048743]; positive regulation of transcription regulatory region DNA binding [GO:2000679] | adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | cadherin binding [GO:0045296]; transcription coactivator activity [GO:0003713] | 62678.45877926675 | -0.162481414481028 | 0.0179968841140949 | 0.0760405260182416 |
| Q9UL25 | Q9UL25 | RAB21_HUMAN | Ras-related protein Rab-21 | RAB21 | anterograde axonal transport [GO:0008089]; intracellular protein transport [GO:0006886]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of receptor-mediated endocytosis [GO:0048260]; protein stabilization [GO:0050821]; Rab protein signal transduction [GO:0032482]; regulation of axon extension [GO:0030516]; regulation of exocytosis [GO:0017157] | axon cytoplasm [GO:1904115]; cleavage furrow [GO:0032154]; cytoplasmic side of early endosome membrane [GO:0098559]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; synapse [GO:0045202]; trans-Golgi network [GO:0005802]; vesicle membrane [GO:0012506] | GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] | 102417.87620530551 | 0.33144149357979 | 0.0180295308961124 | 0.0761217004898458 |
| P14314 | P14314 | GLU2B_HUMAN | Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) | PRKCSH | intracellular signal transduction [GO:0035556]; liver development [GO:0001889]; N-glycan processing [GO:0006491] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; glucosidase II complex [GO:0017177]; intracellular membrane-bounded organelle [GO:0043231] | calcium ion binding [GO:0005509]; phosphoprotein binding [GO:0051219]; protein kinase C binding [GO:0005080]; transmembrane transporter binding [GO:0044325] | 150507.8089576675 | 0.233364986516664 | 0.0180777781935134 | 0.0762685712914718 |
| Q8IV20 | Q8IV20 | LACC1_HUMAN | Purine nucleoside phosphorylase LACC1 (EC 2.4.2.1) (Adenosine deaminase LACC1) (EC 3.5.4.4) (Fatty acid metabolism-immunity nexus) (Guanosine phosphorylase LACC1) (Laccase domain-containing protein 1) (S-methyl-5'-thioadenosine phosphorylase LACC1) (EC 2.4.2.28) | LACC1 | inflammatory response [GO:0006954]; innate immune response [GO:0045087]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of cytokine production involved in immune response [GO:0002720]; regulation of cellular pH [GO:0030641]; regulation of inflammatory response [GO:0050727]; regulation of purine nucleotide metabolic process [GO:1900542] | endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; peroxisome [GO:0005777] | 2'-deoxyadenosine deaminase activity [GO:0046936]; adenosine deaminase activity [GO:0004000]; copper ion binding [GO:0005507]; guanosine phosphorylase activity [GO:0047975]; purine-nucleoside phosphorylase activity [GO:0004731]; S-methyl-5-thioadenosine phosphorylase activity [GO:0017061] | 9901.44032910198 | -0.389635722390326 | 0.0181550734197376 | 0.0764807776923665 |
| P82921 | P82921 | RT21_HUMAN | Small ribosomal subunit protein bS21m (28S ribosomal protein S21, mitochondrial) (MRP-S21) (S21mt) | MRPS21 | mitochondrial translation [GO:0032543]; translation [GO:0006412] | mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 10723.13526050685 | 0.392510435984472 | 0.0181428313675919 | 0.0764807776923665 |
| O00592 | O00592 | PODXL_HUMAN | Podocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1) | PODXL | cell adhesion [GO:0007155]; cell migration [GO:0016477]; epithelial tube formation [GO:0072175]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell-cell adhesion [GO:0022408]; podocyte development [GO:0072015]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; regulation of microvillus assembly [GO:0032534] | apical plasma membrane [GO:0016324]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; membrane raft [GO:0045121]; microvillus membrane [GO:0031528]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; slit diaphragm [GO:0036057] | 12191.6491763303 | 0.701180483684305 | 0.0184611371010007 | 0.0776546420298959 | |
| Q96CP2 | Q96CP2 | FWCH2_HUMAN | FLYWCH family member 2 | FLYWCH2 | RNA binding [GO:0003723] | 15516.139072009999 | 0.421111350154455 | 0.0185175862075167 | 0.0778343052312981 | ||
| Q8WVM8 | Q8WVM8 | SCFD1_HUMAN | Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2) | SCFD1 | cell morphogenesis [GO:0000902]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; negative regulation of autophagosome assembly [GO:1902902]; post-Golgi vesicle-mediated transport [GO:0006892]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of protein transport [GO:0051223]; response to hypoxia [GO:0001666]; response to toxic substance [GO:0009636]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890] | cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; plasma membrane [GO:0005886] | protein-containing complex binding [GO:0044877]; syntaxin binding [GO:0019905] | 32299.27996413465 | -0.160729014827149 | 0.0185803457708545 | 0.0779246773779879 |
| Q96IW7 | Q96IW7 | SC22A_HUMAN | Vesicle-trafficking protein SEC22a (SEC22 vesicle-trafficking protein homolog A) (SEC22 vesicle-trafficking protein-like 2) | SEC22A | endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031] | endoplasmic reticulum membrane [GO:0005789] | SNAP receptor activity [GO:0005484] | 16622.65654356325 | -0.448066465426078 | 0.0185719220877105 | 0.0779246773779879 |
| O75410 | O75410 | TACC1_HUMAN | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | TACC1 | cell division [GO:0051301]; cell population proliferation [GO:0008283]; cerebral cortex development [GO:0021987]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052] | centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; midbody [GO:0030496]; nucleus [GO:0005634] | nuclear estrogen receptor binding [GO:0030331]; nuclear glucocorticoid receptor binding [GO:0035259]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear retinoid X receptor binding [GO:0046965]; nuclear thyroid hormone receptor binding [GO:0046966]; peroxisome proliferator activated receptor binding [GO:0042975] | 5709.890276943435 | 0.356453016865965 | 0.01856306869415 | 0.0779246773779879 |
| Q96NE9 | Q96NE9 | FRMD6_HUMAN | FERM domain-containing protein 6 (Willin) | FRMD6 | apical constriction [GO:0003383]; positive regulation of hippo signaling [GO:0035332]; protein localization [GO:0008104]; regulation of actin filament-based process [GO:0032970] | apical junction complex [GO:0043296]; cytoplasm [GO:0005737]; cytoplasmic side of apical plasma membrane [GO:0098592]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886] | 10602.122234131199 | -0.323452208884648 | 0.0186113611242259 | 0.0779970208061123 | |
| Q15287 | Q15287 | RNPS1_HUMAN | RNA-binding protein with serine-rich domain 1 (SR-related protein LDC2) | RNPS1 | DNA-templated transcription [GO:0006351]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of apoptotic process [GO:0043065]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380] | ASAP complex [GO:0061574]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723] | 30329.347399398903 | 0.315252035748679 | 0.018735896292465 | 0.0784029456374494 |
| Q9C040 | Q9C040 | TRIM2_HUMAN | Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) (RING-type E3 ubiquitin transferase TRIM2) | TRIM2 | negative regulation of translation [GO:0017148]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of neuron apoptotic process [GO:0043523] | cytoplasm [GO:0005737] | translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] | 7994.83866383881 | -0.336932652242098 | 0.0188167546363638 | 0.078683196877961 |
| Q08209 | Q08209 | PP2BA_HUMAN | Protein phosphatase 3 catalytic subunit alpha (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin A alpha) (Calmodulin-dependent calcineurin A subunit alpha isoform) (CNA alpha) (Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform) | PPP3CA | calcineurin-mediated signaling [GO:0097720]; calcineurin-NFAT signaling cascade [GO:0033173]; calcium ion transport [GO:0006816]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cellular response to glucose stimulus [GO:0071333]; dendrite morphogenesis [GO:0048813]; dephosphorylation [GO:0016311]; epidermis development [GO:0008544]; excitatory postsynaptic potential [GO:0060079]; G1/S transition of mitotic cell cycle [GO:0000082]; keratinocyte differentiation [GO:0030216]; modulation of chemical synaptic transmission [GO:0050804]; multicellular organismal response to stress [GO:0033555]; negative regulation of angiotensin-activated signaling pathway [GO:0110062]; negative regulation of calcium ion import across plasma membrane [GO:1905949]; negative regulation of dendrite morphogenesis [GO:0050774]; negative regulation of gene expression [GO:0010629]; negative regulation of insulin secretion [GO:0046676]; negative regulation of signaling [GO:0023057]; peptidyl-serine dephosphorylation [GO:0070262]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; positive regulation of cardiac muscle hypertrophy in response to stress [GO:1903244]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of connective tissue replacement [GO:1905205]; positive regulation of endocytosis [GO:0045807]; positive regulation of gene expression [GO:0010628]; positive regulation of glomerulus development [GO:0090193]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of saliva secretion [GO:0046878]; positive regulation of transcription by RNA polymerase II [GO:0045944]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein dephosphorylation [GO:0006470]; protein import into nucleus [GO:0006606]; regulation of cell proliferation involved in kidney morphogenesis [GO:0061006]; renal filtration [GO:0097205]; response to amphetamine [GO:0001975]; response to calcium ion [GO:0051592]; skeletal muscle fiber development [GO:0048741]; skeletal muscle tissue regeneration [GO:0043403]; T cell activation [GO:0042110]; transition between fast and slow fiber [GO:0014883]; wound healing [GO:0042060] | calcineurin complex [GO:0005955]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extrinsic component of plasma membrane [GO:0019897]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein serine/threonine phosphatase complex [GO:0008287]; sarcolemma [GO:0042383]; Schaffer collateral - CA1 synapse [GO:0098685]; slit diaphragm [GO:0036057]; Z disc [GO:0030018] | ATPase binding [GO:0051117]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; calmodulin-dependent protein phosphatase activity [GO:0033192]; cyclosporin A binding [GO:0016018]; enzyme binding [GO:0019899]; myosin phosphatase activity [GO:0017018]; protein dimerization activity [GO:0046983]; protein serine/threonine phosphatase activity [GO:0004722]; protein-containing complex binding [GO:0044877] | 54481.784887570044 | -0.158110576493195 | 0.0190066431508606 | 0.0793600884987295 |
| Q9H920 | Q9H920 | RN121_HUMAN | E3 ubiquitin ligase RNF121 (EC 2.3.2.27) (RING finger protein 121) | RNF121 | ERAD pathway [GO:0036503]; protein ubiquitination [GO:0016567] | endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] | metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] | 6185.46946340029 | -0.898101004264796 | 0.0192185194082851 | 0.0801266600201202 |
| Q9UM54 | Q9UM54 | MYO6_HUMAN | Unconventional myosin-VI (Unconventional myosin-6) | MYO6 | actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; endocytosis [GO:0006897]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear morphogenesis [GO:0042472]; intracellular protein transport [GO:0006886]; protein localization [GO:0008104]; regulation of secretion [GO:0051046]; response to xenobiotic stimulus [GO:0009410]; sensory perception of sound [GO:0007605]; vesicle transport along actin filament [GO:0030050] | actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; apical part of cell [GO:0045177]; autophagosome [GO:0005776]; cell cortex [GO:0005938]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; filamentous actin [GO:0031941]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microvillus [GO:0005902]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; unconventional myosin complex [GO:0016461] | actin binding [GO:0003779]; actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; cytoskeletal motor activity [GO:0003774]; identical protein binding [GO:0042802]; microfilament motor activity [GO:0000146]; minus-end directed microfilament motor activity [GO:0060001] | 9708.120088500771 | -0.320523628841366 | 0.0192568746480842 | 0.0802275380559156 |
| Q9H1X3 | Q9H1X3 | DJC25_HUMAN | DnaJ homolog subfamily C member 25 | DNAJC25 | protein folding [GO:0006457] | endoplasmic reticulum membrane [GO:0005789] | 9251.871595639976 | 0.379142285678753 | 0.0193378234392525 | 0.0805055897184459 | |
| P08240 | P08240 | SRPRA_HUMAN | Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha) | SRPRA | cotranslational protein targeting to membrane [GO:0006613]; intracellular protein transport [GO:0006886]; protein targeting to ER [GO:0045047]; SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [GO:0006617] | endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; signal recognition particle receptor complex [GO:0005785] | ATP hydrolysis activity [GO:0016887]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; signal recognition particle binding [GO:0005047] | 29063.25312232145 | -0.125220917820506 | 0.0195882774420619 | 0.0814285986696426 |
| Q8TAE6 | Q8TAE6 | PP14C_HUMAN | Protein phosphatase 1 regulatory subunit 14C (Kinase-enhanced PP1 inhibitor) (PKC-potentiated PP1 inhibitory protein) (Serologically defined breast cancer antigen NY-BR-81) | PPP1R14C | regulation of phosphorylation [GO:0042325] | cytoplasm [GO:0005737]; membrane [GO:0016020] | protein serine/threonine phosphatase inhibitor activity [GO:0004865] | 7252.672358792341 | 1.60233231966701 | 0.0196179151441756 | 0.0814920140813041 |
| P52306 | P52306 | GDS1_HUMAN | Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein) | RAP1GDS1 | angiotensin-activated signaling pathway involved in heart process [GO:0086098]; CAAX-box protein maturation [GO:0080120]; cardiac muscle hypertrophy [GO:0003300]; myosin filament assembly [GO:0031034]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; protein localization to nucleus [GO:0034504]; regulation of ERK5 cascade [GO:0070376]; regulation of matrix metallopeptidase secretion [GO:1904464]; regulation of mitochondrion organization [GO:0010821]; vascular associated smooth muscle contraction [GO:0014829] | cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleus [GO:0005634] | guanyl-nucleotide exchange factor activity [GO:0005085] | 20197.5767239446 | -0.137914307231615 | 0.0196886980995179 | 0.081666298266375 |
| Q5JVS0 | Q5JVS0 | HABP4_HUMAN | Intracellular hyaluronan-binding protein 4 (IHABP-4) (IHABP4) (Hyaluronan-binding protein 4) (Ki-1/57 intracellular antigen) | HABP4 | cellular response to mechanical stimulus [GO:0071260]; mRNA processing [GO:0006397]; negative regulation of DNA binding [GO:0043392]; PML body organization [GO:0030578]; positive regulation of RNA splicing [GO:0033120]; positive regulation of translational initiation [GO:0045948]; ribosome hibernation [GO:0141014]; RNA splicing [GO:0008380] | Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular region [GO:0005576]; Gemini of coiled bodies [GO:0097504]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; sarcomere [GO:0030017]; sarcoplasm [GO:0016528] | ribosome binding [GO:0043022]; RNA binding [GO:0003723]; SUMO binding [GO:0032183]; translation elongation factor binding [GO:0061770] | 13991.4927110668 | 0.281751140875426 | 0.0197424183873117 | 0.0818292191532611 |
| Q9Y385 | Q9Y385 | UB2J1_HUMAN | Ubiquitin-conjugating enzyme E2 J1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme J1) (Non-canonical ubiquitin-conjugating enzyme 1) (NCUBE-1) (Yeast ubiquitin-conjugating enzyme UBC6 homolog E) (HsUBC6e) | UBE2J1 | ERAD pathway [GO:0036503]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein N-linked glycosylation via asparagine [GO:0018279]; protein polyubiquitination [GO:0000209]; regulation of macrophage cytokine production [GO:0010935]; regulation of tumor necrosis factor production [GO:0032680]; spermatid development [GO:0007286] | endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] | ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625] | 12509.622639497451 | 0.578264498820206 | 0.0198227644602083 | 0.0821021808710088 |
| P29323 | P29323 | EPHB2_HUMAN | Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2] | EPHB2 | angiogenesis [GO:0001525]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; B cell activation [GO:0042113]; camera-type eye morphogenesis [GO:0048593]; cellular response to amyloid-beta [GO:1904646]; cellular response to lipopolysaccharide [GO:0071222]; central nervous system projection neuron axonogenesis [GO:0021952]; commissural neuron axon guidance [GO:0071679]; corpus callosum development [GO:0022038]; dendritic spine development [GO:0060996]; dendritic spine morphogenesis [GO:0060997]; ephrin receptor signaling pathway [GO:0048013]; hindbrain tangential cell migration [GO:0021934]; inner ear morphogenesis [GO:0042472]; learning [GO:0007612]; learning or memory [GO:0007611]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of NMDA glutamate receptor activity [GO:1904782]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of Ras protein signal transduction [GO:0046580]; nervous system development [GO:0007399]; neuron projection retraction [GO:0106028]; optic nerve morphogenesis [GO:0021631]; peptidyl-tyrosine phosphorylation [GO:0018108]; phosphorylation [GO:0016310]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell migration [GO:0030335]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of gene expression [GO:0010628]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of NMDA glutamate receptor activity [GO:1904783]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of tumor necrosis factor production [GO:0032760]; postsynaptic membrane assembly [GO:0097104]; regulation of autophagosome assembly [GO:2000785]; regulation of behavioral fear response [GO:2000822]; regulation of blood coagulation [GO:0030193]; regulation of body fluid levels [GO:0050878]; regulation of filopodium assembly [GO:0051489]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; regulation of T-helper 17 type immune response [GO:2000316]; retinal ganglion cell axon guidance [GO:0031290]; roof of mouth development [GO:0060021]; tight junction assembly [GO:0120192]; trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission [GO:0099557]; urogenital system development [GO:0001655]; vesicle-mediated intercellular transport [GO:0110077] | axon [GO:0030424]; cell surface [GO:0009986]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734] | amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; axon guidance receptor activity [GO:0008046]; identical protein binding [GO:0042802]; protein tyrosine kinase activity [GO:0004713]; protein-containing complex binding [GO:0044877]; signaling receptor binding [GO:0005102]; transmembrane-ephrin receptor activity [GO:0005005] | 4813.80230072564 | 0.487427623613654 | 0.0199804993938413 | 0.0826950398579289 |
| Q14919 | Q14919 | NC2A_HUMAN | Dr1-associated corepressor (Dr1-associated protein 1) (Negative cofactor 2-alpha) (NC2-alpha) | DRAP1 | negative regulation of transcription by RNA polymerase II [GO:0000122]; transcription by RNA polymerase II [GO:0006366] | negative cofactor 2 complex [GO:0017054]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] | core promoter sequence-specific DNA binding [GO:0001046]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; TBP-class protein binding [GO:0017025] | 13357.7581083934 | 0.8582874697873 | 0.0202223669903256 | 0.0835739834917468 |
| O00193 | O00193 | SMAP_HUMAN | Small acidic protein | SMAP | 81410.365027364 | 0.446445350656299 | 0.0202684326092914 | 0.0837033084287499 | |||
| Q9H7F0 | Q9H7F0 | AT133_HUMAN | Polyamine-transporting ATPase 13A3 (ATPase family homolog up-regulated in senescence cells 1) (Putrescine transporting ATPase) (EC 7.6.2.16) | ATP13A3 | intracellular calcium ion homeostasis [GO:0006874]; polyamine transmembrane transport [GO:1902047] | early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; recycling endosome membrane [GO:0055038] | ABC-type putrescine transporter activity [GO:0015594]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; metal ion binding [GO:0046872]; P-type ion transporter activity [GO:0015662]; P-type transmembrane transporter activity [GO:0140358]; polyamine transmembrane transporter activity [GO:0015203] | 4954.03372354163 | 0.507563661888651 | 0.0203685184540645 | 0.0840553718577782 |
| P57076 | P57076 | CF298_HUMAN | Cilia- and flagella-associated protein 298 (Protein kurly homolog) | CFAP298 | cilium assembly [GO:0060271]; regulation of cilium movement [GO:0003352] | cilium [GO:0005929]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634] | 2548.901592682005 | 0.900418019343335 | 0.0206468827542115 | 0.0851420943852712 | |
| O60313 | O60313 | OPA1_HUMAN | Dynamin-like GTPase OPA1, mitochondrial (EC 3.6.5.5) (Optic atrophy protein 1) [Cleaved into: Dynamin-like GTPase OPA1, long form (L-OPA1); Dynamin-like GTPase OPA1, short form (S-OPA1)] | OPA1 | apoptotic process [GO:0006915]; axonal transport of mitochondrion [GO:0019896]; cellular senescence [GO:0090398]; GTP metabolic process [GO:0046039]; inner mitochondrial membrane organization [GO:0007007]; membrane tubulation [GO:0097749]; mitochondrial fission [GO:0000266]; mitochondrial fusion [GO:0008053]; mitochondrial genome maintenance [GO:0000002]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; neural tube closure [GO:0001843]; protein complex oligomerization [GO:0051259]; visual perception [GO:0007601] | axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrial crista [GO:0030061]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] | cardiolipin binding [GO:1901612]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; microtubule binding [GO:0008017]; phosphatidic acid binding [GO:0070300] | 11107.41216884025 | -0.126572135016223 | 0.0207116180400784 | 0.0853469293200612 |
| P00734 | P00734 | THRB_HUMAN | Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain] | F2 | acute-phase response [GO:0006953]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; blood coagulation [GO:0007596]; cell surface receptor signaling pathway [GO:0007166]; cytolysis by host of symbiont cells [GO:0051838]; fibrinolysis [GO:0042730]; G protein-coupled receptor signaling pathway [GO:0007186]; ligand-gated ion channel signaling pathway [GO:1990806]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of platelet activation [GO:0010544]; negative regulation of proteolysis [GO:0045861]; neutrophil-mediated killing of gram-negative bacterium [GO:0070945]; platelet activation [GO:0030168]; positive regulation of blood coagulation [GO:0030194]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of insulin secretion [GO:0032024]; positive regulation of lipid kinase activity [GO:0090218]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900738]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; proteolysis [GO:0006508]; regulation of blood coagulation [GO:0030193]; regulation of cell shape [GO:0008360]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to wounding [GO:0009611] | blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886] | calcium ion binding [GO:0005509]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; lipopolysaccharide binding [GO:0001530]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102]; thrombospondin receptor activity [GO:0070053] | 9074.53823941643 | 0.762373294640952 | 0.0207610821273808 | 0.0854885838181247 |
| Q9UPQ7 | Q9UPQ7 | PZRN3_HUMAN | E3 ubiquitin-protein ligase PDZRN3 (EC 2.3.2.27) (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (RING-type E3 ubiquitin transferase PDZRN3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3) | PDZRN3 | neuromuscular junction development [GO:0007528]; protein ubiquitination [GO:0016567] | cytoplasm [GO:0005737]; neuromuscular junction [GO:0031594] | ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] | 2783.81626193249 | 1.6187637061096 | 0.0207940004163734 | 0.0855619508781202 |
| P49356 | P49356 | FNTB_HUMAN | Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta) | FNTB | lipid metabolic process [GO:0006629]; protein farnesylation [GO:0018343] | cytosol [GO:0005829]; microtubule associated complex [GO:0005875]; protein farnesyltransferase complex [GO:0005965] | protein farnesyltransferase activity [GO:0004660]; zinc ion binding [GO:0008270] | 17347.90513868615 | -0.223891286332768 | 0.0209451247089879 | 0.0861212457192492 |
| Q13257 | Q13257 | MD2L1_HUMAN | Mitotic spindle assembly checkpoint protein MAD2A (HsMAD2) (Mitotic arrest deficient 2-like protein 1) (MAD2-like protein 1) | MAD2L1 | cell division [GO:0051301]; establishment of centrosome localization [GO:0051660]; establishment of mitotic spindle orientation [GO:0000132]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of apoptotic process [GO:0043066]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; mitotic checkpoint complex [GO:0033597]; mitotic spindle [GO:0072686]; mitotic spindle assembly checkpoint MAD1-MAD2 complex [GO:1990728]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; spindle pole [GO:0000922] | identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] | 7020.18949504991 | -0.528208500943969 | 0.0210054574296656 | 0.086306687307096 |
| O75347 | O75347 | TBCA_HUMAN | Tubulin-specific chaperone A (TCP1-chaperonin cofactor A) (Tubulin-folding cofactor A) (CFA) | TBCA | post-chaperonin tubulin folding pathway [GO:0007023]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleolus [GO:0005730] | beta-tubulin binding [GO:0048487]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; tubulin binding [GO:0015631] | 92535.13626076709 | 0.378477833320356 | 0.0211370312315324 | 0.0867843615636686 |
| Q16740 | Q16740 | CLPP_HUMAN | ATP-dependent Clp protease proteolytic subunit, mitochondrial (EC 3.4.21.92) (Endopeptidase Clp) | CLPP | membrane protein proteolysis [GO:0033619]; mitochondrial protein catabolic process [GO:0035694]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603] | endopeptidase Clp complex [GO:0009368]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] | ATP-dependent peptidase activity [GO:0004176]; ATPase binding [GO:0051117]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252] | 13579.79197070155 | -0.272073069501902 | 0.0211537463314111 | 0.0867900989962167 |
| P26572 | P26572 | MGAT1_HUMAN | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.101) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I) (GNT-I) (GlcNAc-T I) | MGAT1 | in utero embryonic development [GO:0001701]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; UDP-N-acetylglucosamine catabolic process [GO:0006049]; viral protein processing [GO:0019082] | endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471] | acetylglucosaminyltransferase activity [GO:0008375]; alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity [GO:0003827]; manganese ion binding [GO:0030145] | 28673.911552908197 | 0.193298302759322 | 0.0211824187695092 | 0.0868448514819386 |
| Q9Y2R9 | Q9Y2R9 | RT07_HUMAN | Small ribosomal subunit protein uS7m (28S ribosomal protein S7, mitochondrial) (MRP-S7) (S7mt) (bMRP-27a) (bMRP27a) | MRPS7 | mitochondrial translation [GO:0032543]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] | cytosolic small ribosomal subunit [GO:0022627]; mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; ribosome [GO:0005840] | mRNA binding [GO:0003729]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] | 5836.449374582235 | 0.423928726525886 | 0.0212862070902095 | 0.0872072663580094 |
| Q9BY42 | Q9BY42 | RTF2_HUMAN | Replication termination factor 2 (RTF2) (Replication termination factor 2 domain-containing protein 1) | RTF2 | cellular response to hydroxyurea [GO:0072711]; mitotic DNA replication termination [GO:1902979]; regulation of DNA stability [GO:0097752] | nucleus [GO:0005634]; replication fork [GO:0005657] | DNA binding [GO:0003677] | 5628.726760719044 | 0.234557773542242 | 0.0213076278204142 | 0.0872319503110311 |
| P63104 | P63104 | 1433Z_HUMAN | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | YWHAZ | angiogenesis [GO:0001525]; cellular response to glucose starvation [GO:0042149]; ERK1 and ERK2 cascade [GO:0070371]; establishment of Golgi localization [GO:0051683]; Golgi reassembly [GO:0090168]; lung development [GO:0030324]; negative regulation of apoptotic process [GO:0043066]; negative regulation of innate immune response [GO:0045824]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein phosphorylation [GO:0006468]; protein targeting [GO:0006605]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of protein stability [GO:0031647]; regulation of synapse maturation [GO:0090128]; respiratory system process [GO:0003016]; signal transduction [GO:0007165]; synaptic target recognition [GO:0008039]; tube formation [GO:0035148] | blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; melanosome [GO:0042470]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; vesicle [GO:0031982] | cadherin binding [GO:0045296]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; phosphoserine residue binding [GO:0050815]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625] | 266527.099608152 | 0.213474401170236 | 0.0213237527294109 | 0.0872349335486225 |
| Q9NXR1 | Q9NXR1 | NDE1_HUMAN | Nuclear distribution protein nudE homolog 1 (NudE) | NDE1 | cell division [GO:0051301]; cell migration [GO:0016477]; centrosome duplication [GO:0051298]; centrosome localization [GO:0051642]; cerebral cortex development [GO:0021987]; chromosome segregation [GO:0007059]; establishment of chromosome localization [GO:0051303]; establishment of mitotic spindle orientation [GO:0000132]; microtubule nucleation [GO:0007020]; mitotic centrosome separation [GO:0007100]; neuroblast proliferation [GO:0007405]; neuron migration [GO:0001764]; vesicle transport along microtubule [GO:0047496] | centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; membrane [GO:0016020]; microtubule [GO:0005874]; spindle pole centrosome [GO:0031616]; synapse [GO:0045202] | identical protein binding [GO:0042802]; microtubule binding [GO:0008017] | 7745.948360685245 | 0.329587581862986 | 0.0213747946700079 | 0.0873806541127451 |
| Q9NVQ4 | Q9NVQ4 | FAIM1_HUMAN | Fas apoptotic inhibitory molecule 1 | FAIM | apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; positive regulation of neurogenesis [GO:0050769] | cytoplasm [GO:0005737] | 4489.957195135195 | 0.659758007511149 | 0.0214856348357413 | 0.0877072096392723 | |
| P61006 | P61006 | RAB8A_HUMAN | Ras-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel) | RAB8A | autophagy [GO:0006914]; axonogenesis [GO:0007409]; cellular response to insulin stimulus [GO:0032869]; cilium assembly [GO:0060271]; endocytic recycling [GO:0032456]; Golgi organization [GO:0007030]; Golgi vesicle fusion to target membrane [GO:0048210]; neurotransmitter receptor transport to postsynaptic membrane [GO:0098969]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; protein localization to cilium [GO:0061512]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; regulation of autophagy [GO:0010506]; regulation of exocytosis [GO:0017157]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of protein transport [GO:0051223]; vesicle docking involved in exocytosis [GO:0006904]; vesicle-mediated transport in synapse [GO:0099003] | centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; midbody [GO:0030496]; neuronal cell body [GO:0043025]; non-motile cilium [GO:0097730]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; recycling endosome membrane [GO:0055038]; synaptic vesicle [GO:0008021]; trans-Golgi network membrane [GO:0032588]; trans-Golgi network transport vesicle [GO:0030140] | GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; protein tyrosine kinase binding [GO:1990782]; small GTPase binding [GO:0031267] | 16214.518163753899 | 0.187062738053925 | 0.0215107517223549 | 0.0877465221446095 |
| O60493 | O60493 | SNX3_HUMAN | Sorting nexin-3 (Protein SDP3) | SNX3 | endocytic recycling [GO:0032456]; intralumenal vesicle formation [GO:0070676]; late endosome to Golgi transport [GO:0034499]; membrane invagination [GO:0010324]; negative regulation of early endosome to late endosome transport [GO:2000642]; negative regulation of phagocytosis [GO:0050765]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein transport [GO:0051224]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of neuron projection development [GO:0010976]; protein to membrane docking [GO:0022615]; protein transport [GO:0015031]; regulation of Wnt signaling pathway [GO:0030111]; response to bacterium [GO:0009617] | clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; retromer complex [GO:0030904] | phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; protein phosphatase binding [GO:0019903]; retromer complex binding [GO:1905394] | 61706.79431267425 | 0.337858145433597 | 0.0215882635527633 | 0.0879993534460119 |
| Q9BZM4 | Q9BZM4 | ULBP3_HUMAN | UL16-binding protein 3 (ALCAN-gamma) (NKG2D ligand 3) (N2DL-3) (NKG2DL3) (Retinoic acid early transcript 1N) | ULBP3 | antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; positive regulation of T cell mediated cytotoxicity [GO:0001916] | external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] | natural killer cell lectin-like receptor binding [GO:0046703] | 4165.707140451685 | 0.776053614310747 | 0.0216165446542398 | 0.0880512882896642 |
| P13987 | P13987 | CD59_HUMAN | CD59 glycoprotein (1F5 antigen) (20 kDa homologous restriction factor) (HRF-20) (HRF20) (MAC-inhibitory protein) (MAC-IP) (MEM43 antigen) (Membrane attack complex inhibition factor) (MACIF) (Membrane inhibitor of reactive lysis) (MIRL) (Protectin) (CD antigen CD59) | CD59 | blood coagulation [GO:0007596]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of activation of membrane attack complex [GO:0001971]; regulation of complement activation [GO:0030449]; regulation of complement-dependent cytotoxicity [GO:1903659] | cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; transport vesicle [GO:0030133]; vesicle [GO:0031982] | complement binding [GO:0001848] | 48913.2479812956 | 0.637619055552446 | 0.0216970289597926 | 0.0883156365561673 |
| Q9UJY1 | Q9UJY1 | HSPB8_HUMAN | Heat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (E2-induced gene 1 protein) (Heat shock protein family B member 8) (Protein kinase H11) (Small stress protein-like protein HSP22) | HSPB8 | cellular response to unfolded protein [GO:0034620]; positive regulation of aggrephagy [GO:1905337] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031] | identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] | 15167.66754350755 | 0.409171687824101 | 0.0218582769517098 | 0.0887806431601346 |
| P24390 | P24390 | ERD21_HUMAN | ER lumen protein-retaining receptor 1 (KDEL endoplasmic reticulum protein retention receptor 1) (KDEL receptor 1) (Putative MAPK-activating protein PM23) | KDELR1 | endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein retention in ER lumen [GO:0006621]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; T cell apoptotic process [GO:0070231]; T cell differentiation [GO:0030217] | cis-Golgi network [GO:0005801]; COPI-coated vesicle membrane [GO:0030663]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133] | ER retention sequence binding [GO:0046923]; KDEL sequence binding [GO:0005046] | 3101.44496409483 | -0.640527108979097 | 0.0218554730951542 | 0.0887806431601346 |
| P56192 | P56192 | SYMC_HUMAN | Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS) | MARS1 | cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; methionyl-tRNA aminoacylation [GO:0006431]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; rRNA transcription [GO:0009303]; tRNA aminoacylation for protein translation [GO:0006418] | aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730] | ATP binding [GO:0005524]; methionine-tRNA ligase activity [GO:0004825]; tRNA binding [GO:0000049] | 23876.40288581865 | -0.237161902187507 | 0.0220811544141665 | 0.0896216482168104 |
| Q9BTZ2 | Q9BTZ2 | DHRS4_HUMAN | Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase) (CR) (NADPH-dependent retinol dehydrogenase/reductase) (NRDR) (humNRDR) (Peroxisomal short-chain alcohol dehydrogenase) (PSCD) (SCAD-SRL) (Short chain dehydrogenase/reductase family 25C member 2) (Protein SDR25C2) (Short-chain dehydrogenase/reductase family member 4) | DHRS4 | alcohol metabolic process [GO:0006066]; cellular ketone metabolic process [GO:0042180]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; retinal metabolic process [GO:0042574]; steroid metabolic process [GO:0008202] | cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] | 3-keto sterol reductase activity [GO:0000253]; 3beta-hydroxy-5beta-steroid dehydrogenase activity [GO:0033703]; alcohol dehydrogenase [NAD(P)+] activity [GO:0018455]; carbonyl reductase (NADPH) activity [GO:0004090]; identical protein binding [GO:0042802]; NADP-retinol dehydrogenase activity [GO:0052650]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; retinal dehydrogenase activity [GO:0001758] | 5988.448615904665 | -0.71259817170415 | 0.0221903668762054 | 0.0900004428923262 |
| P27708 | P27708 | PYR1_HUMAN | Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] | CAD | 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; animal organ regeneration [GO:0031100]; cellular response to epidermal growth factor stimulus [GO:0071364]; citrulline biosynthetic process [GO:0019240]; female pregnancy [GO:0007565]; glutamine metabolic process [GO:0006541]; heart development [GO:0007507]; lactation [GO:0007595]; liver development [GO:0001889]; peptidyl-threonine phosphorylation [GO:0018107]; protein autophosphorylation [GO:0046777]; response to amine [GO:0014075]; response to caffeine [GO:0031000]; response to cortisol [GO:0051414]; response to insulin [GO:0032868]; response to starvation [GO:0042594]; response to testosterone [GO:0033574]; UDP biosynthetic process [GO:0006225]; UTP biosynthetic process [GO:0006228]; xenobiotic metabolic process [GO:0006805] | cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; terminal bouton [GO:0043195] | aspartate binding [GO:0070335]; aspartate carbamoyltransferase activity [GO:0004070]; ATP binding [GO:0005524]; carbamoyl-phosphate synthase (ammonia) activity [GO:0004087]; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [GO:0004088]; dihydroorotase activity [GO:0004151]; enzyme binding [GO:0019899]; glutaminase activity [GO:0004359]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; zinc ion binding [GO:0008270] | 13072.76026408955 | -0.314802514188776 | 0.0223677926175035 | 0.0906551594926859 |
| Q00169 | Q00169 | PIPNA_HUMAN | Phosphatidylinositol transfer protein alpha isoform (PI-TP-alpha) (PtdIns transfer protein alpha) (PtdInsTP alpha) | PITPNA | axonogenesis [GO:0007409]; lipid metabolic process [GO:0006629]; phospholipid transport [GO:0015914]; visual perception [GO:0007601] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] | lipid binding [GO:0008289]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transfer activity [GO:0120019]; phosphatidylcholine transporter activity [GO:0008525]; phosphatidylglycerol binding [GO:1901611]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526] | 31183.86100309485 | 0.282788417721015 | 0.0224404304112776 | 0.0908845451824868 |
| Q9BRF8 | Q9BRF8 | CPPED_HUMAN | Serine/threonine-protein phosphatase CPPED1 (EC 3.1.3.16) (Calcineurin-like phosphoesterase domain-containing protein 1) (Complete S-transactivated protein 1) | CPPED1 | azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] | metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018] | 15966.538555180101 | -0.26537815185615 | 0.0224926081989308 | 0.090979813091478 | |
| Q9H0N0 | Q9H0N0 | RAB6C_HUMAN | Ras-related protein Rab-6C (Rab6-like protein WTH3) | RAB6C | intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; mitotic cell cycle [GO:0000278]; regulation of centrosome duplication [GO:0010824]; response to xenobiotic stimulus [GO:0009410]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; small GTPase-mediated signal transduction [GO:0007264] | centrosome [GO:0005813]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634] | GTP binding [GO:0005525]; GTPase activity [GO:0003924] | 24665.81559084745 | -1.2962191569247 | 0.0228499757917305 | 0.0923451946048109 |
| Q9BT67 | Q9BT67 | NFIP1_HUMAN | NEDD4 family-interacting protein 1 (Breast cancer-associated protein SGA-1M) (NEDD4 WW domain-binding protein 5) (Putative MAPK-activating protein PM13) (Putative NF-kappa-B-activating protein 164) (Putative NFKB and MAPK-activating protein) | NDFIP1 | CD4-positive, alpha-beta T cell proliferation [GO:0035739]; intracellular iron ion homeostasis [GO:0006879]; metal ion transport [GO:0030001]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-4 production [GO:0032713]; negative regulation of isotype switching to IgE isotypes [GO:0048294]; negative regulation of protein transport [GO:0051224]; negative regulation of transporter activity [GO:0032410]; negative regulation of type 2 immune response [GO:0002829]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein ubiquitination [GO:0031398]; regulation of isotype switching to IgG isotypes [GO:0048302]; regulation of lymphocyte differentiation [GO:0045619]; regulation of myeloid leukocyte differentiation [GO:0002761]; ubiquitin-dependent protein catabolic process [GO:0006511]; vacuolar transport [GO:0007034] | cell cortex [GO:0005938]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; synapse [GO:0045202] | WW domain binding [GO:0050699] | 17195.86619547475 | -0.594893928081286 | 0.0231322180612951 | 0.0932862260037709 |
| Q86W92 | Q86W92 | LIPB1_HUMAN | Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2) | PPFIBP1 | cell adhesion [GO:0007155]; neuromuscular junction development [GO:0007528] | cytosol [GO:0005829]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786] | cadherin binding [GO:0045296] | 21200.6215902009 | -0.227733902666812 | 0.0232042683491331 | 0.0935102307725378 |
| O00139 | O00139 | KIF2A_HUMAN | Kinesin-like protein KIF2A (Kinesin-2) (hK2) | KIF2A | cell differentiation [GO:0030154]; cell division [GO:0051301]; microtubule cytoskeleton organization [GO:0000226]; microtubule depolymerization [GO:0007019]; microtubule-based movement [GO:0007018]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; nervous system development [GO:0007399]; regulation of cell migration [GO:0030334] | centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spindle [GO:0005819]; spindle pole [GO:0000922] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cytoskeletal motor activity [GO:0003774]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] | 15650.860394634801 | -0.20870495051587 | 0.023262662034618 | 0.0936123885569217 |
| Q9NVZ3 | Q9NVZ3 | NECP2_HUMAN | Adaptin ear-binding coat-associated protein 2 (NECAP endocytosis-associated protein 2) (NECAP-2) | NECAP2 | endocytosis [GO:0006897]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] | clathrin vesicle coat [GO:0030125]; clathrin-coated pit [GO:0005905]; plasma membrane [GO:0005886] | 31278.31338115075 | 0.287918921055887 | 0.0232599375585293 | 0.0936123885569217 | |
| Q9H6F5 | Q9H6F5 | CCD86_HUMAN | Coiled-coil domain-containing protein 86 (Cytokine-induced protein with coiled-coil domain) | CCDC86 | chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | RNA binding [GO:0003723] | 7807.886808016195 | 0.393525095588363 | 0.0234944052057284 | 0.0944108509898277 | |
| Q9NQ66 | Q9NQ66 | PLCB1_HUMAN | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1) | PLCB1 | activation of meiosis involved in egg activation [GO:0060466]; cellular response to fluoride [GO:1902618]; cellular response to glyceraldehyde [GO:1905631]; cellular response to ionomycin [GO:1904637]; cellular response to vasopressin [GO:1904117]; cerebral cortex development [GO:0021987]; fat cell differentiation [GO:0045444]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; G protein-coupled receptor signaling pathway [GO:0007186]; G2/M transition of mitotic cell cycle [GO:0000086]; glutamate receptor signaling pathway [GO:0007215]; inositol trisphosphate metabolic process [GO:0032957]; insulin-like growth factor receptor signaling pathway [GO:0048009]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-12-mediated signaling pathway [GO:0035722]; interleukin-15-mediated signaling pathway [GO:0035723]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; learning [GO:0007612]; ligand-gated ion channel signaling pathway [GO:1990806]; memory [GO:0007613]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of monocyte extravasation [GO:2000438]; phosphatidylinositol catabolic process [GO:0031161]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of CD24 production [GO:2000560]; positive regulation of developmental growth [GO:0048639]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of embryonic development [GO:0040019]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of insulin secretion [GO:0032024]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of JNK cascade [GO:0046330]; positive regulation of myoblast differentiation [GO:0045663]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of fertilization [GO:0080154]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of retrograde trans-synaptic signaling by endocanabinoid [GO:0099178]; release of sequestered calcium ion into cytosol [GO:0051209]; signal transduction [GO:0007165] | chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524] | calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802]; lamin binding [GO:0005521]; phosphatidylinositol phospholipase C activity [GO:0004435]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phospholipase C activity [GO:0004629] | 6318.998714745645 | 0.746554873769351 | 0.0234852916929616 | 0.0944108509898277 |
| Q14C86 | Q14C86 | GAPD1_HUMAN | GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6) | GAPVD1 | endocytosis [GO:0006897]; regulation of protein transport [GO:0051223] | cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; plasma membrane [GO:0005886] | cadherin binding [GO:0045296]; GTPase activating protein binding [GO:0032794]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] | 15713.28550193535 | -0.326027594512984 | 0.0235860542925348 | 0.0946138255593148 |
| P15260 | P15260 | INGR1_HUMAN | Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119) | IFNGR1 | astrocyte activation [GO:0048143]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; microglial cell activation [GO:0001774]; negative regulation of amyloid-beta clearance [GO:1900222]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of gene expression [GO:0010628]; positive regulation of tumor necrosis factor production [GO:0032760]; response to virus [GO:0009615]; signal transduction [GO:0007165]; type II interferon-mediated signaling pathway [GO:0060333]; type III interferon-mediated signaling pathway [GO:0038196] | membrane [GO:0016020]; plasma membrane [GO:0005886] | cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; type II interferon receptor activity [GO:0004906] | 5091.1069174359 | -0.251500776488221 | 0.023595011562886 | 0.0946138255593148 |
| Q15758 | Q15758 | AAAT_HUMAN | Neutral amino acid transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5) | SLC1A5 | amino acid transport [GO:0006865]; erythrocyte differentiation [GO:0030218]; glutamine secretion [GO:0010585]; glutamine transport [GO:0006868]; L-aspartate import across plasma membrane [GO:0140009]; L-glutamine import across plasma membrane [GO:1903803]; neutral amino acid transport [GO:0015804]; protein homotrimerization [GO:0070207]; transport across blood-brain barrier [GO:0150104] | basal plasma membrane [GO:0009925]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886] | amino acid transmembrane transporter activity [GO:0015171]; antiporter activity [GO:0015297]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamine transmembrane transporter activity [GO:0015186]; L-serine transmembrane transporter activity [GO:0015194]; ligand-gated channel activity [GO:0022834]; metal ion binding [GO:0046872]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; signaling receptor activity [GO:0038023]; symporter activity [GO:0015293]; virus receptor activity [GO:0001618] | 54488.59245691595 | -0.176013593102178 | 0.0236412803107578 | 0.0947323155875201 |
| Q9NYB9 | Q9NYB9 | ABI2_HUMAN | Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) | ABI2 | actin polymerization or depolymerization [GO:0008154]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; lens fiber cell morphogenesis [GO:0070309]; neuron migration [GO:0001764]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of lamellipodium assembly [GO:0010592]; Rac protein signal transduction [GO:0016601]; regulation of dendritic spine morphogenesis [GO:0061001]; zonula adherens assembly [GO:0045186] | actin-based cell projection [GO:0098858]; adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; filopodium tip [GO:0032433]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; SCAR complex [GO:0031209] | cytoskeletal anchor activity [GO:0008093]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; proline-rich region binding [GO:0070064]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591]; ubiquitin protein ligase binding [GO:0031625] | 8875.52466083024 | 0.251140838353105 | 0.0237003771499912 | 0.0949020048988341 |
| Q9H1Z4 | Q9H1Z4 | WDR13_HUMAN | WD repeat-containing protein 13 | WDR13 | negative regulation of type B pancreatic cell proliferation [GO:1904691] | centriolar satellite [GO:0034451]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | promoter-specific chromatin binding [GO:1990841] | 14724.64154084555 | -0.160655604141641 | 0.0238088606119749 | 0.0952690707820972 |
| Q9NVD7 | Q9NVD7 | PARVA_HUMAN | Alpha-parvin (Actopaxin) (CH-ILKBP) (Calponin-like integrin-linked kinase-binding protein) (Matrix-remodeling-associated protein 2) | PARVA | actin cytoskeleton organization [GO:0030036]; actin-mediated cell contraction [GO:0070252]; cilium assembly [GO:0060271]; establishment or maintenance of cell polarity [GO:0007163]; heterotypic cell-cell adhesion [GO:0034113]; outflow tract septum morphogenesis [GO:0003148]; protein stabilization [GO:0050821]; regulation of cell shape [GO:0008360]; smooth muscle cell chemotaxis [GO:0071670]; sprouting angiogenesis [GO:0002040]; substrate adhesion-dependent cell spreading [GO:0034446] | actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Z disc [GO:0030018] | actin binding [GO:0003779]; cadherin binding [GO:0045296]; protein kinase inhibitor activity [GO:0004860] | 41373.84648477965 | -0.195481757839624 | 0.024062390089466 | 0.096147744884989 |
| P25685 | P25685 | DNJB1_HUMAN | DnaJ homolog subfamily B member 1 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40) (Human DnaJ protein 1) (hDj-1) | DNAJB1 | cellular response to heat [GO:0034605]; chaperone cofactor-dependent protein refolding [GO:0051085]; forebrain development [GO:0030900]; negative regulation of inclusion body assembly [GO:0090084]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ATP-dependent activity [GO:0032781]; regulation of cellular response to heat [GO:1900034]; response to unfolded protein [GO:0006986] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; sperm head [GO:0061827] | ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; cadherin binding [GO:0045296]; Hsp70 protein binding [GO:0030544]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]; unfolded protein binding [GO:0051082] | 19320.9783136588 | 0.27551374264278 | 0.0243574790627141 | 0.0970427355408258 |
| P11177 | P11177 | ODPB_HUMAN | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1) | PDHB | acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; glucose metabolic process [GO:0006006]; tricarboxylic acid cycle [GO:0006099] | mitochondrial matrix [GO:0005759]; mitochondrial pyruvate dehydrogenase complex [GO:0005967]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pyruvate dehydrogenase complex [GO:0045254] | pyruvate dehydrogenase (acetyl-transferring) activity [GO:0004739] | 29192.61204504155 | -0.225487061807185 | 0.0243869986541526 | 0.0970427355408258 |
| Q01995 | Q01995 | TAGL_HUMAN | Transgelin (22 kDa actin-binding protein) (Protein WS3-10) (Smooth muscle protein 22-alpha) (SM22-alpha) | TAGLN | actin filament organization [GO:0007015]; epithelial cell differentiation [GO:0030855]; muscle organ development [GO:0007517] | actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737] | actin filament binding [GO:0051015] | 1239701.21011789 | -0.325395611359213 | 0.0243891379121313 | 0.0970427355408258 |
| P34810 | P34810 | CD68_HUMAN | Macrosialin (Gp110) (CD antigen CD68) | CD68 | cellular response to lipopolysaccharide [GO:0071222]; cellular response to nutrient levels [GO:0031669]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; establishment of protein localization to organelle [GO:0072594]; inflammatory response to antigenic stimulus [GO:0002437]; negative regulation of dendritic cell antigen processing and presentation [GO:0002605] | azurophil granule membrane [GO:0035577]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886] | 7293.7357086736 | 0.898274887947542 | 0.0245180311701156 | 0.0974187690111326 | |
| Q96DB5 | Q96DB5 | RMD1_HUMAN | Regulator of microtubule dynamics protein 1 (RMD-1) (hRMD-1) (Protein FAM82B) | RMDN1 | attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; mitotic spindle organization [GO:0007052] | cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; mitotic spindle pole [GO:0097431]; spindle microtubule [GO:0005876] | microtubule binding [GO:0008017] | 33416.76678703655 | 0.346334935564098 | 0.0245019539436228 | 0.0974187690111326 |
| P49593 | P49593 | PPM1F_HUMAN | Protein phosphatase 1F (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase) (CaM-kinase phosphatase) (CaMKPase) (Partner of PIX 2) (Protein fem-2 homolog) (hFem-2) | PPM1F | cellular response to xenobiotic stimulus [GO:0071466]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of protein transport [GO:0051224]; peptidyl-serine dephosphorylation [GO:0070262]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of chemotaxis [GO:0050921]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of growth [GO:0045927]; positive regulation of stress fiber assembly [GO:0051496]; regulation of protein localization [GO:0032880] | cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991] | calmodulin-dependent protein phosphatase activity [GO:0033192]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138] | 13014.98491167465 | 0.295226171495231 | 0.0245866752151292 | 0.0976230566005062 |
| Q9H0V9 | Q9H0V9 | LMA2L_HUMAN | VIP36-like protein (Lectin mannose-binding 2-like) (LMAN2-like protein) | LMAN2L | endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein folding [GO:0006457]; protein transport [GO:0015031] | COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] | mannose binding [GO:0005537]; metal ion binding [GO:0046872] | 15115.7961370044 | 0.288414542713673 | 0.0246314514139249 | 0.0977323555401251 |
| Q9BZQ6 | Q9BZQ6 | EDEM3_HUMAN | ER degradation-enhancing alpha-mannosidase-like protein 3 (EC 3.2.1.113) (Alpha-1,2-mannosidase EDEM3) | EDEM3 | carbohydrate metabolic process [GO:0005975]; ERAD pathway [GO:0036503]; mannoprotein catabolic process [GO:0006058]; protein glycosylation [GO:0006486]; response to unfolded protein [GO:0006986] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum quality control compartment [GO:0044322]; membrane [GO:0016020] | calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571] | 8425.016000302685 | 0.275449843546613 | 0.0247122465566924 | 0.0979843169980542 |
| P13073 | P13073 | COX41_HUMAN | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) | COX4I1 | cellular respiration [GO:0045333]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123] | cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] | cytochrome-c oxidase activity [GO:0004129] | 145255.2697039275 | 0.354275013609394 | 0.0249547021809524 | 0.0988764633267667 |
| O14737 | O14737 | PDCD5_HUMAN | Programmed cell death protein 5 (TF-1 cell apoptosis-related protein 19) (Protein TFAR19) | PDCD5 | apoptotic process [GO:0006915]; cellular response to transforming growth factor beta stimulus [GO:0071560]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chaperone-mediated protein folding [GO:1903645]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of gene expression [GO:0010628]; positive regulation of protein insertion into mitochondrial outer membrane [GO:1903638]; positive regulation of release of cytochrome c from mitochondria [GO:0090200] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] | acetyltransferase activator activity [GO:0010698]; beta-tubulin binding [GO:0048487]; DNA binding [GO:0003677]; heparin binding [GO:0008201] | 73279.37976115325 | 0.450170506186012 | 0.0250428174706952 | 0.0991562570153454 |
| Q13451 | Q13451 | FKBP5_HUMAN | Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase) | FKBP5 | chaperone-mediated protein folding [GO:0061077]; protein folding [GO:0006457]; response to bacterium [GO:0009617] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654] | FK506 binding [GO:0005528]; heat shock protein binding [GO:0031072]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein-macromolecule adaptor activity [GO:0030674] | 8047.250775600845 | 0.609195452798384 | 0.0250933164044559 | 0.0992868231477983 |
| Q9NQC7 | Q9NQC7 | CYLD_HUMAN | Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) | CYLD | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [GO:0043369]; cell cycle [GO:0007049]; homeostasis of number of cells [GO:0048872]; innate immune response [GO:0045087]; necroptotic process [GO:0070266]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-18-mediated signaling pathway [GO:2000493]; negative regulation of JNK cascade [GO:0046329]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of p38MAPK cascade [GO:1903753]; negative regulation of type I interferon production [GO:0032480]; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0035872]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of protein localization [GO:1903829]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of T cell receptor signaling pathway [GO:0050862]; protein deubiquitination [GO:0016579]; protein linear deubiquitination [GO:1990108]; proteolysis [GO:0006508]; regulation of B cell differentiation [GO:0045577]; regulation of cilium assembly [GO:1902017]; regulation of inflammatory response [GO:0050727]; regulation of intrinsic apoptotic signaling pathway [GO:2001242]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of mitotic cell cycle [GO:0007346]; regulation of necroptotic process [GO:0060544]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; ripoptosome assembly involved in necroptotic process [GO:1901026]; Wnt signaling pathway [GO:0016055] | centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cytosol [GO:0005829]; microtubule [GO:0005874]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; spindle [GO:0005819] | cysteine-type deubiquitinase activity [GO:0004843]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]; Met1-linked polyubiquitin deubiquitinase activity [GO:0061815]; proline-rich region binding [GO:0070064]; protein kinase binding [GO:0019901]; zinc ion binding [GO:0008270] | 6884.612195443246 | 0.629230328973185 | 0.0251524948657234 | 0.0993821728794901 |
| Q96AC1 | Q96AC1 | FERM2_HUMAN | Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1) | FERMT2 | adherens junction maintenance [GO:0034334]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; focal adhesion assembly [GO:0048041]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; limb development [GO:0060173]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of vascular permeability [GO:0043116]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of GTPase activity [GO:0043547]; positive regulation of integrin activation [GO:0033625]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; positive regulation of myosin light chain kinase activity [GO:0035505]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of wound healing, spreading of epidermal cells [GO:1903691]; protein localization to cell junction [GO:1902414]; protein localization to membrane [GO:0072657]; regulation of cell morphogenesis [GO:0022604]; regulation of cell shape [GO:0008360]; substrate adhesion-dependent cell spreading [GO:0034446]; transforming growth factor beta receptor signaling pathway [GO:0007179]; Wnt signaling pathway [GO:0016055] | adherens junction [GO:0005912]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; focal adhesion [GO:0005925]; I band [GO:0031674]; lamellipodium membrane [GO:0031258]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stress fiber [GO:0001725] | actin binding [GO:0003779]; actin filament binding [GO:0051015]; integrin binding [GO:0005178]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; protein kinase binding [GO:0019901]; SMAD binding [GO:0046332]; type I transforming growth factor beta receptor binding [GO:0034713] | 42534.65041225525 | -0.252652022934954 | 0.0252083552898252 | 0.0994641650920263 |
| Q8TDW0 | Q8TDW0 | LRC8C_HUMAN | Volume-regulated anion channel subunit LRRC8C (Factor for adipocyte differentiation 158) (Leucine-rich repeat-containing protein 8C) | LRRC8C | aspartate transmembrane transport [GO:0015810]; cellular response to osmotic stress [GO:0071470]; cyclic-GMP-AMP transmembrane import across plasma membrane [GO:0140361]; fat cell differentiation [GO:0045444]; monoatomic anion transmembrane transport [GO:0098656]; protein hexamerization [GO:0034214]; taurine transport [GO:0015734] | cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] | volume-sensitive anion channel activity [GO:0005225] | 5100.06892874601 | 0.469930890579866 | 0.0251919151796124 | 0.0994641650920263 |
| Q9UHV9 | Q9UHV9 | PFD2_HUMAN | Prefoldin subunit 2 | PFDN2 | chaperone-mediated protein folding [GO:0061077]; negative regulation of amyloid fibril formation [GO:1905907]; positive regulation of cytoskeleton organization [GO:0051495]; protein folding [GO:0006457]; protein stabilization [GO:0050821] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; prefoldin complex [GO:0016272]; protein folding chaperone complex [GO:0101031]; RPAP3/R2TP/prefoldin-like complex [GO:1990062] | amyloid-beta binding [GO:0001540]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082] | 70245.72341161134 | 0.383448559221376 | 0.0252982983684441 | 0.099749588417261 |
| P55145 | P55145 | MANF_HUMAN | Mesencephalic astrocyte-derived neurotrophic factor (Arginine-rich protein) (Protein ARMET) | MANF | dopaminergic neuron differentiation [GO:0071542]; neuron projection development [GO:0031175]; regulation of response to endoplasmic reticulum stress [GO:1905897]; response to unfolded protein [GO:0006986]; vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure [GO:0002014] | cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; sarcoplasmic reticulum lumen [GO:0033018] | growth factor activity [GO:0008083]; RNA binding [GO:0003723]; sulfatide binding [GO:0120146] | 49230.2318776289 | 0.408566375542225 | 0.0255535771960194 | 0.100616100342353 |
| P17050 | P17050 | NAGAB_HUMAN | Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) (Alpha-galactosidase B) | NAGA | carbohydrate catabolic process [GO:0016052]; glycolipid catabolic process [GO:0019377]; glycoside catabolic process [GO:0016139]; oligosaccharide metabolic process [GO:0009311] | cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; lysosome [GO:0005764] | alpha-galactosidase activity [GO:0004557]; alpha-N-acetylgalactosaminidase activity [GO:0008456]; protein homodimerization activity [GO:0042803] | 18448.7639195821 | 0.198307886742406 | 0.0255453752239222 | 0.100616100342353 |
| Q9H299 | Q9H299 | SH3L3_HUMAN | SH3 domain-binding glutamic acid-rich-like protein 3 (SH3 domain-binding protein 1) (SH3BP-1) (TNF inhibitory protein B1) (TIP-B1) | SH3BGRL3 | cytoskeleton organization [GO:0007010] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear body [GO:0016604]; ruffle membrane [GO:0032587] | 606114.3462857645 | -0.406531528292681 | 0.0256321450418234 | 0.100855370699286 | |
| Q96KR1 | Q96KR1 | ZFR_HUMAN | Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog) | ZFR | chromosome [GO:0005694]; cytoplasm [GO:0005737]; precatalytic spliceosome [GO:0071011] | DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270] | 9616.015411834316 | -0.223263513885446 | 0.0256934491423933 | 0.1010264280644 | |
| Q9Y6D6 | Q9Y6D6 | BIG1_HUMAN | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) | ARFGEF1 | endomembrane system organization [GO:0010256]; exocytosis [GO:0006887]; Golgi organization [GO:0007030]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of GTPase activity [GO:0034260]; positive regulation of wound healing [GO:0090303]; protein glycosylation [GO:0006486]; protein transport [GO:0015031]; regulation of ARF protein signal transduction [GO:0032012]; regulation of establishment of cell polarity [GO:2000114] | cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; small nuclear ribonucleoprotein complex [GO:0030532]; trans-Golgi network [GO:0005802] | guanyl-nucleotide exchange factor activity [GO:0005085]; myosin binding [GO:0017022]; protein kinase A regulatory subunit binding [GO:0034237] | 5622.296788186065 | -0.383776759939378 | 0.0257415003315869 | 0.101145173979731 |
| Q8N2G8 | Q8N2G8 | GHDC_HUMAN | GH3 domain-containing protein | GHDC | cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; secretory granule lumen [GO:0034774]; specific granule lumen [GO:0035580] | acid-amino acid ligase activity [GO:0016881]; indole-3-acetic acid amido synthetase activity [GO:0010279] | 5596.790485780461 | -0.324729080023946 | 0.0258760132640798 | 0.101603250973164 | |
| Q9Y282 | Q9Y282 | ERGI3_HUMAN | Endoplasmic reticulum-Golgi intermediate compartment protein 3 (Serologically defined breast cancer antigen NY-BR-84) | ERGIC3 | endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of intracellular protein transport [GO:0090316]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890] | COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; retrograde transporter complex, Golgi to ER [GO:0061852]; transporter complex [GO:1990351] | protein self-association [GO:0043621] | 23749.929292143803 | 0.257165749781985 | 0.025922282708953 | 0.101714441709784 |
| Q14257 | Q14257 | RCN2_HUMAN | Reticulocalbin-2 (Calcium-binding protein ERC-55) (E6-binding protein) (E6BP) | RCN2 | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; nucleolus [GO:0005730] | calcium ion binding [GO:0005509] | 47910.63163489995 | 0.345955691200133 | 0.0264179357256118 | 0.103444384119776 | |
| Q92968 | Q92968 | PEX13_HUMAN | Peroxisomal membrane protein PEX13 (Peroxin-13) | PEX13 | cellular response to reactive oxygen species [GO:0034614]; cerebral cortex cell migration [GO:0021795]; fatty acid alpha-oxidation [GO:0001561]; locomotory behavior [GO:0007626]; microtubule-based peroxisome localization [GO:0060152]; neuron migration [GO:0001764]; protein import into peroxisome matrix, docking [GO:0016560]; protein import into peroxisome matrix, translocation [GO:0016561]; suckling behavior [GO:0001967] | cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal importomer complex [GO:1990429]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] | protein transmembrane transporter activity [GO:0008320] | 8240.83918295202 | 0.474172389018533 | 0.026467760394575 | 0.103567907731811 |
| P09341 | P09341 | GROA_HUMAN | Growth-regulated alpha protein (C-X-C motif chemokine 1) (GRO-alpha(1-73)) (Melanoma growth stimulatory activity) (MGSA) (Neutrophil-activating protein 3) (NAP-3) [Cleaved into: GRO-alpha(4-73); GRO-alpha(5-73); GRO-alpha(6-73)] | CXCL1 | actin cytoskeleton organization [GO:0030036]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; neutrophil chemotaxis [GO:0030593]; signal transduction [GO:0007165] | extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] | chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; enzyme activator activity [GO:0008047]; growth factor activity [GO:0008083]; signaling receptor binding [GO:0005102] | 7141.075581729635 | 3.29009630677355 | 0.0265021164060512 | 0.103630774021177 |
| Q14554 | Q14554 | PDIA5_HUMAN | Protein disulfide-isomerase A5 (EC 5.3.4.1) (Protein disulfide isomerase-related protein) | PDIA5 | electron transport chain [GO:0022900]; protein folding [GO:0006457] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789] | oxidoreductase activity [GO:0016491]; protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035] | 47534.533126570896 | 0.181708359912564 | 0.026674776208461 | 0.104183244507791 |
| P04424 | P04424 | ARLY_HUMAN | Argininosuccinate lyase (ASAL) (EC 4.3.2.1) (Arginosuccinase) | ASL | ammonia assimilation cycle [GO:0019676]; arginine biosynthetic process [GO:0006526]; arginine biosynthetic process via ornithine [GO:0042450]; arginine metabolic process [GO:0006525]; locomotory behavior [GO:0007626]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; post-embryonic development [GO:0009791]; urea cycle [GO:0000050] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] | argininosuccinate lyase activity [GO:0004056]; identical protein binding [GO:0042802] | 38858.10061105045 | 0.127342470870177 | 0.0267592450296609 | 0.104348164031699 |
| P10620 | P10620 | MGST1_HUMAN | Microsomal glutathione S-transferase 1 (Microsomal GST-1) (EC 2.5.1.18) (Microsomal GST-I) | MGST1 | cellular response to lipid hydroperoxide [GO:0071449]; glutathione transport [GO:0034635] | azurophil granule membrane [GO:0035577]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; plasma membrane [GO:0005886] | glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364] | 22496.6460712118 | -0.543418292082097 | 0.0267456071714782 | 0.104348164031699 |
| Q6QNY0 | Q6QNY0 | BL1S3_HUMAN | Biogenesis of lysosome-related organelles complex 1 subunit 3 (BLOC-1 subunit 3) | BLOC1S3 | anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; endosome to melanosome transport [GO:0035646]; eye development [GO:0001654]; melanosome organization [GO:0032438]; melanosome transport [GO:0032402]; neuron projection development [GO:0031175]; pigmentation [GO:0043473]; platelet activation [GO:0030168]; platelet dense granule organization [GO:0060155]; positive regulation of natural killer cell activation [GO:0032816]; response to xenobiotic stimulus [GO:0009410]; secretion of lysosomal enzymes [GO:0033299] | axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; cytosol [GO:0005829]; transport vesicle [GO:0030133] | protein transmembrane transporter activity [GO:0008320] | 14054.91265728835 | 0.53721797674836 | 0.0268199816308556 | 0.104513078349675 |
| O95433 | O95433 | AHSA1_HUMAN | Activator of 90 kDa heat shock protein ATPase homolog 1 (AHA1) (p38) | AHSA1 | positive regulation of ATP-dependent activity [GO:0032781]; protein folding [GO:0006457] | cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062] | ATPase activator activity [GO:0001671]; cadherin binding [GO:0045296]; Hsp90 protein binding [GO:0051879]; protein-folding chaperone binding [GO:0051087] | 63051.7227165724 | 0.192700033592862 | 0.0269618259643289 | 0.1048494893026 |
| P09496 | P09496 | CLCA_HUMAN | Clathrin light chain A (Lca) | CLTA | cell cycle [GO:0007049]; cell division [GO:0051301]; clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886] | clathrin coat [GO:0030118]; clathrin coat of coated pit [GO:0030132]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin complex [GO:0071439]; clathrin vesicle coat [GO:0030125]; clathrin-coated endocytic vesicle [GO:0045334]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic endocytic zone cytoplasmic component [GO:0099631]; presynaptic endocytic zone membrane [GO:0098835]; spindle [GO:0005819]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network membrane [GO:0032588] | clathrin heavy chain binding [GO:0032050]; GTPase binding [GO:0051020]; peptide binding [GO:0042277]; protein-containing complex binding [GO:0044877]; structural molecule activity [GO:0005198] | 402259.259983179 | 0.332346170464286 | 0.0269504393875174 | 0.1048494893026 |
| P54920 | P54920 | SNAA_HUMAN | Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha) | NAPA | apical protein localization [GO:0045176]; brain development [GO:0007420]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; neuron differentiation [GO:0030182]; regulation of synaptic vesicle priming [GO:0010807]; SNARE complex disassembly [GO:0035494]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle priming [GO:0016082] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptobrevin 2-SNAP-25-syntaxin-1a complex [GO:0070044]; terminal bouton [GO:0043195]; vacuolar membrane [GO:0005774] | protein-containing complex binding [GO:0044877]; SNARE binding [GO:0000149]; soluble NSF attachment protein activity [GO:0005483]; syntaxin binding [GO:0019905] | 51602.909872255754 | 0.0900659508482726 | 0.0269592986408661 | 0.1048494893026 |
| P55735 | P55735 | SEC13_HUMAN | Protein SEC13 homolog (GATOR2 complex protein SEC13) (SEC13-like protein 1) (SEC13-related protein) | SEC13 | cellular response to nutrient levels [GO:0031669]; COPII-coated vesicle budding [GO:0090114]; COPII-coated vesicle cargo loading [GO:0090110]; intracellular protein transport [GO:0006886]; mRNA transport [GO:0051028]; negative regulation of TORC1 signaling [GO:1904262]; nucleocytoplasmic transport [GO:0006913]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein exit from endoplasmic reticulum [GO:0032527]; protein import into nucleus [GO:0006606] | COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; extracellular exosome [GO:0070062]; GATOR2 complex [GO:0061700]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; nucleoplasm [GO:0005654] | identical protein binding [GO:0042802]; structural molecule activity [GO:0005198] | 74380.5144493313 | 0.190739771049938 | 0.0270959102700037 | 0.105298647180961 |
| Q8NDZ4 | Q8NDZ4 | DIK2A_HUMAN | Divergent protein kinase domain 2A (Deleted in autism protein 1) (Golgi Protein of 49 kDa) (GoPro49) (Hypoxia and AKT-induced stem cell factor) (HASF) | DIPK2A | cardiac muscle cell proliferation [GO:0060038]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; positive regulation of protein kinase C activity [GO:1900020]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896] | COPI vesicle coat [GO:0030126]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139] | 13087.1406806727 | 0.303363765496185 | 0.0274159552903877 | 0.106392340124668 | |
| P82909 | P82909 | KGD4_HUMAN | Alpha-ketoglutarate dehydrogenase component 4 (Alpha-ketoglutarate dehydrogenase subunit 4) | KGD4 | 2-oxoglutarate metabolic process [GO:0006103]; tricarboxylic acid cycle [GO:0006099] | mitochondrial inner membrane [GO:0005743]; mitochondrial oxoglutarate dehydrogenase complex [GO:0009353]; mitochondrion [GO:0005739]; oxoglutarate dehydrogenase complex [GO:0045252] | oxoglutarate dehydrogenase (succinyl-transferring) activity [GO:0004591]; protein-macromolecule adaptor activity [GO:0030674] | 34747.680931677896 | 0.457151938328776 | 0.0274336761246277 | 0.106392340124668 |
| Q99417 | Q99417 | MYCBP_HUMAN | c-Myc-binding protein (Associate of Myc 1) (AMY-1) | MYCBP | regulation of DNA-templated transcription [GO:0006355]; spermatogenesis [GO:0007283] | cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | transcription coactivator activity [GO:0003713] | 39982.674532591656 | 0.35038708052892 | 0.0274211726225663 | 0.106392340124668 |
| Q9H3P2 | Q9H3P2 | NELFA_HUMAN | Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein) | NELFA | negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of protein modification process [GO:0031401]; positive regulation of transcription by RNA polymerase II [GO:0045944] | cytosol [GO:0005829]; NELF complex [GO:0032021]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | chromatin binding [GO:0003682]; molecular adaptor activity [GO:0060090] | 7878.802128678785 | -0.272276281579675 | 0.0275085936850296 | 0.106609912325156 |
| Q8NC51 | Q8NC51 | SERB1_HUMAN | SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) | SERBP1 | negative regulation of translation [GO:0017148]; PML body organization [GO:0030578]; regulation of mRNA stability [GO:0043488]; ribosome hibernation [GO:0141014] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; non-membrane-bounded organelle [GO:0043228]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] | cadherin binding [GO:0045296]; mRNA 3'-UTR binding [GO:0003730]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; SUMO binding [GO:0032183]; translation elongation factor binding [GO:0061770]; translation repressor activity [GO:0030371] | 80386.7313250152 | 0.329438785375984 | 0.0278280934684854 | 0.107774420774052 |
| Q15035 | Q15035 | TRAM2_HUMAN | Translocating chain-associated membrane protein 2 | TRAM2 | collagen biosynthetic process [GO:0032964]; protein insertion into ER membrane [GO:0045048]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616] | membrane [GO:0016020] | 24222.538352630298 | -0.305427535026037 | 0.0280839874072035 | 0.108536350818992 | |
| Q13404 | Q13404 | UB2V1_HUMAN | Ubiquitin-conjugating enzyme E2 variant 1 (UEV-1) (CROC-1) (TRAF6-regulated IKK activator 1 beta Uev1A) | UBE2V1 | cell differentiation [GO:0030154]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; postreplication repair [GO:0006301]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; UBC13-UEV1A complex [GO:0035370]; ubiquitin conjugating enzyme complex [GO:0031371]; ubiquitin ligase complex [GO:0000151] | 213723.723013685 | 0.298782668926665 | 0.0281014519328382 | 0.108536350818992 | |
| Q96ND0 | Q96ND0 | F210A_HUMAN | Protein FAM210A | FAM210A | cytoplasm [GO:0005737]; membrane [GO:0016020]; mitochondrion [GO:0005739] | 8114.6262305482505 | 0.762936504251375 | 0.028190573276818 | 0.108806395222378 | ||
| O00566 | O00566 | MPP10_HUMAN | U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10) | MPHOSPH10 | maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit biogenesis [GO:0042274]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375] | chromosome [GO:0005694]; Mpp10 complex [GO:0034457]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732] | RNA binding [GO:0003723] | 4359.75397226787 | 0.379237688875544 | 0.028240018177568 | 0.108923038117155 |
| A6ND36 | A6ND36 | FA83G_HUMAN | Protein FAM83G (Protein associated with SMAD1) | FAM83G | BMP signaling pathway [GO:0030509]; epidermal growth factor receptor signaling pathway [GO:0007173]; intermediate filament cytoskeleton organization [GO:0045104]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of cell migration [GO:0030335]; protein localization to mitotic spindle [GO:1902480]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of TOR signaling [GO:0032006] | cytosol [GO:0005829]; keratin filament [GO:0045095]; membrane [GO:0016020]; mitotic spindle pole [GO:0097431]; nucleus [GO:0005634] | keratin filament binding [GO:1990254]; protein kinase binding [GO:0019901] | 4099.47262135931 | 0.740378450408312 | 0.0283030180519233 | 0.109091768899454 |
| P20618 | P20618 | PSB1_HUMAN | Proteasome subunit beta type-1 (Macropain subunit C5) (Multicatalytic endopeptidase complex subunit C5) (Proteasome component C5) (Proteasome gamma chain) | PSMB1 | proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; proteolysis involved in protein catabolic process [GO:0051603] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]; secretory granule lumen [GO:0034774] | 126404.376510959 | 0.154672122035801 | 0.0283692133430855 | 0.10927257838336 | |
| P43234 | P43234 | CATO_HUMAN | Cathepsin O (EC 3.4.22.42) | CTSO | proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603] | extracellular space [GO:0005615]; lysosome [GO:0005764] | cysteine-type endopeptidase activity [GO:0004197] | 15539.6280884468 | 0.47409728318147 | 0.0284219369486014 | 0.10940128719482 |
| Q16186 | Q16186 | ADRM1_HUMAN | Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Proteasome regulatory particle non-ATPase 13) (hRpn13) (Rpn13 homolog) | ADRM1 | proteasome assembly [GO:0043248]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; transcription elongation by RNA polymerase II [GO:0006368] | cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; proteasome complex [GO:0000502]; proteasome regulatory particle, lid subcomplex [GO:0008541] | endopeptidase activator activity [GO:0061133]; molecular function inhibitor activity [GO:0140678]; protease binding [GO:0002020]; proteasome binding [GO:0070628] | 31312.80219648225 | 0.265036678487839 | 0.0285874995265461 | 0.10996386443816 |
| Q7Z3U7 | Q7Z3U7 | MON2_HUMAN | Protein MON2 homolog (Protein SF21) | MON2 | Golgi to endosome transport [GO:0006895]; protein transport [GO:0015031] | cytosol [GO:0005829]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062] | 7623.496257773685 | -0.41606055420421 | 0.0288518584296196 | 0.110848121455131 | |
| Q8WU90 | Q8WU90 | ZC3HF_HUMAN | Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Likely ortholog of mouse immediate early response erythropoietin 4) | ZC3H15 | cytokine-mediated signaling pathway [GO:0019221]; cytoplasmic translation [GO:0002181]; positive regulation of GTPase activity [GO:0043547] | cytosol [GO:0005829]; nucleus [GO:0005634] | cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] | 15526.048247446051 | 0.31667749875387 | 0.0288904178716877 | 0.11090318947221 |
| Q7Z6Z7 | Q7Z6Z7 | HUWE1_HUMAN | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | HUWE1 | base-excision repair [GO:0006284]; cell differentiation [GO:0030154]; circadian regulation of gene expression [GO:0032922]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; negative regulation of mitochondrial fusion [GO:0010637]; positive regulation of mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination [GO:0031398]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774] | DNA binding [GO:0003677]; histone ubiquitin ligase activity [GO:0140852]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] | 10951.15212382855 | -0.314034628131524 | 0.0292513762425877 | 0.112212794712595 |
| Q709C8 | Q709C8 | VP13C_HUMAN | Intermembrane lipid transfer protein VPS13C (Vacuolar protein sorting-associated protein 13C) | VPS13C | Golgi to endosome transport [GO:0006895]; lipid transport [GO:0006869]; mitochondrion organization [GO:0007005]; negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [GO:1905090]; protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623]; response to insulin [GO:0032868] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; dense core granule membrane [GO:0032127]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extrinsic component of membrane [GO:0019898]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; mitochondrial outer membrane [GO:0005741] | 4565.9817962189645 | -0.538785822936082 | 0.0292732126094338 | 0.112220583657004 | |
| P30533 | P30533 | AMRP_HUMAN | Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) | LRPAP1 | amyloid-beta clearance by transcytosis [GO:0150093]; extracellular negative regulation of signal transduction [GO:1900116]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of protein binding [GO:0032091]; negative regulation of receptor internalization [GO:0002091]; negative regulation of very-low-density lipoprotein particle clearance [GO:0010916]; positive regulation of amyloid-beta clearance [GO:1900223]; regulation of receptor-mediated endocytosis [GO:0048259]; signal transduction [GO:0007165] | cell surface [GO:0009986]; cis-Golgi network [GO:0005801]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome [GO:0005768]; endosome lumen [GO:0031904]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; rough endoplasmic reticulum lumen [GO:0048237] | amyloid-beta binding [GO:0001540]; heparin binding [GO:0008201]; lipase binding [GO:0035473]; low-density lipoprotein particle receptor binding [GO:0050750]; receptor antagonist activity [GO:0048019]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; very-low-density lipoprotein particle receptor binding [GO:0070326] | 20379.4655410458 | 0.33485728571113 | 0.0295987705589039 | 0.113344278737433 |
| Q13595 | Q13595 | TRA2A_HUMAN | Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A) | TRA2A | mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026] | intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] | RNA binding [GO:0003723] | 18907.510232619898 | 0.234585997058346 | 0.0296933657054879 | 0.113524028398984 |
| Q14353 | Q14353 | GAMT_HUMAN | Guanidinoacetate N-methyltransferase (EC 2.1.1.2) | GAMT | animal organ morphogenesis [GO:0009887]; creatine biosynthetic process [GO:0006601]; creatine metabolic process [GO:0006600]; methylation [GO:0032259]; muscle contraction [GO:0006936]; regulation of multicellular organism growth [GO:0040014]; spermatogenesis [GO:0007283] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] | guanidinoacetate N-methyltransferase activity [GO:0030731]; methyltransferase activity [GO:0008168]; protein arginine N5-methyltransferase activity [GO:0019702] | 8685.593970327825 | -0.942935057871452 | 0.0297200850949853 | 0.1135495631478 |
| Q99733 | Q99733 | NP1L4_HUMAN | Nucleosome assembly protein 1-like 4 (Nucleosome assembly protein 2) (NAP-2) | NAP1L4 | nucleosome assembly [GO:0006334] | chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634] | chromatin binding [GO:0003682]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082] | 103376.73117120235 | 0.217085203945418 | 0.0301733852991381 | 0.115126196030247 |
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| Q15149 | |||||||||
| Q99715 | |||||||||
| P02452 | |||||||||
| P02751 | |||||||||
| P98160 | |||||||||
| P08123 | |||||||||
| P02461 | |||||||||
| P07996 | |||||||||
| Q8WWI1 | |||||||||
| P05997 | |||||||||
| P20908 | |||||||||
| Q8WUJ3 | |||||||||
| P21333 | |||||||||
| O75369 | |||||||||
| Q15063 | |||||||||
| P02786 | |||||||||
| Q12884 | |||||||||
| P12814 | |||||||||
| Q9UDY2 | |||||||||
| Q14195 | |||||||||
| Q02952 | |||||||||
| Q9NZM1 | |||||||||
| P35579 | |||||||||
| P35354 | |||||||||
| P47895 | |||||||||
| Q09666 | |||||||||
| P11717 | |||||||||
| Q14112 | |||||||||
| Q13620 | |||||||||
| P43490 | |||||||||
| Q3SY69 | |||||||||
| P17812 | |||||||||
| P21980 | |||||||||
| Q16647 | |||||||||
| P01024 | |||||||||
| Q5SW79 | |||||||||
| P06396 | |||||||||
| P12111 | |||||||||
| P35221 | |||||||||
| P12429 | |||||||||
| P78559 | |||||||||
| Q76M96 | |||||||||
| Q16881 | |||||||||
| P07093 | |||||||||
| P27487 | |||||||||
| P15144 | |||||||||
| Q9H5V8 | |||||||||
| P08729 | |||||||||
| Q04828 | |||||||||
| O94925 | |||||||||
| P08473 | |||||||||
| Q8IVL5 | |||||||||
| P35442 | |||||||||
| O60716 | |||||||||
| P08253 | |||||||||
| Q16822 | |||||||||
| Q9UJ72 | |||||||||
| Q9Y617 | |||||||||
| Q8WX93 | |||||||||
| Q32MZ4 | |||||||||
| Q6P179 | |||||||||
| P48681 | |||||||||
| O95340 | |||||||||
| P21580 | |||||||||
| Q00341 | |||||||||
| P49748 | |||||||||
| O43854 | |||||||||
| P07942 | |||||||||
| Q96KC8 | |||||||||
| Q96PD2 | |||||||||
| Q13418 | |||||||||
| Q7Z7G0 | |||||||||
| Q04446 | |||||||||
| P19022 | |||||||||
| O00469 | |||||||||
| Q8WUF5 | |||||||||
| Q14767 | |||||||||
| Q13308 | |||||||||
| P46940 | |||||||||
| Q9NZ08 | |||||||||
| O60488 | |||||||||
| P35222 | |||||||||
| Q9H4M9 | |||||||||
| Q9NZU5 | |||||||||
| Q15113 | |||||||||
| O94808 | |||||||||
| Q9UI42 | |||||||||
| Q15417 | |||||||||
| Q15582 | |||||||||
| P35908 | |||||||||
| P00750 | |||||||||
| Q9UHD8 | |||||||||
| P11047 | |||||||||
| Q8N6G6 | |||||||||
| Q05682 | |||||||||
| P17342 | |||||||||
| Q16363 | |||||||||
| Q9NR12 | |||||||||
| P05362 | |||||||||
| P00966 | |||||||||
| P05120 | |||||||||
| P15121 | |||||||||
| P04179 | |||||||||
| Q15785 | |||||||||
| O60271 | |||||||||
| Q9Y6N5 | |||||||||
| Q9P0V9 | |||||||||
| Q8IVF2 | |||||||||
| P01584 | |||||||||
| Q96AQ6 | |||||||||
| P54289 | |||||||||
| P13667 | |||||||||
| Q96HE7 | |||||||||
| P21810 | |||||||||
| Q16790 | |||||||||
| P23396 | |||||||||
| P01130 | |||||||||
| P51812 | |||||||||
| O95490 | |||||||||
| Q16222 | |||||||||
| Q7Z4N8 | |||||||||
| P08133 | |||||||||
| Q08431 | |||||||||
| P23142 | |||||||||
| Q01581 | |||||||||
| P10915 | |||||||||
| O75976 | |||||||||
| P23219 | |||||||||
| Q8IXK2 | |||||||||
| Q07954 | |||||||||
| P50225 | |||||||||
| P11413 | |||||||||
| Q5SSJ5 | |||||||||
| Q6PCE3 | |||||||||
| P05091 | |||||||||
| P49419 | |||||||||
| P41252 | |||||||||
| P50281 | |||||||||
| Q13618 | |||||||||
| Q00653 | |||||||||
| Q9BZG1 | |||||||||
| P11142 | |||||||||
| P63010 | |||||||||
| Q9UBG0 | |||||||||
| Q5GLZ8 | |||||||||
| P21266 | |||||||||
| Q9BS40 | |||||||||
| P35232 | |||||||||
| Q86VP6 | |||||||||
| P09601 | |||||||||
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| Q16851 | |||||||||
| P28845 | |||||||||
| P26640 | |||||||||
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| P07686 | |||||||||
| P01583 | |||||||||
| Q96HH9 | |||||||||
| P48506 | |||||||||
| P47712 | |||||||||
| Q14314 | |||||||||
| Q53FA7 | |||||||||
| Q9H425 | |||||||||
| Q14204 | |||||||||
| P01033 | |||||||||
| Q92616 | |||||||||
| Q16666 | |||||||||
| Q99623 | |||||||||
| P23381 | |||||||||
| Q8N6Y2 | |||||||||
| P98155 | |||||||||
| P46977 | |||||||||
| Q86SQ0 | |||||||||
| Q70E73 | |||||||||
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| P41250 | |||||||||
| P56945 | |||||||||
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| P26022 | |||||||||
| P00492 | |||||||||
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| P50452 | |||||||||
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| O75094 | |||||||||
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| P48307 | |||||||||
| P08648 | |||||||||
| O43175 | |||||||||
| O00116 |
