Selected Cell
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stat_data__min_2_Peptides
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| Q9UBR2 | Q9UBR2 | CATZ_HUMAN | Cathepsin Z (EC 3.4.18.1) (Cathepsin P) (Cathepsin X) | CTSZ | angiotensin maturation [GO:0002003]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; negative regulation of plasminogen activation [GO:0010757]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603] | cell cortex [GO:0005938]; collagen-containing extracellular matrix [GO:0062023]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580] | carboxypeptidase activity [GO:0004180]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234] | 124997.593212836 | -0.39943822582134 | 0.00393249963018591 | 0.0218118886733898 |
| O15228 | O15228 | GNPAT_HUMAN | Dihydroxyacetone phosphate acyltransferase (DAP-AT) (DAPAT) (DHAP-AT) (EC 2.3.1.42) (Acyl-CoA:dihydroxyacetonephosphateacyltransferase) (Glycerone-phosphate O-acyltransferase) | GNPAT | cerebellum morphogenesis [GO:0021587]; ether lipid biosynthetic process [GO:0008611]; fatty acid metabolic process [GO:0006631]; glycerol-3-phosphate metabolic process [GO:0006072]; membrane organization [GO:0061024]; paranodal junction assembly [GO:0030913]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid biosynthetic process [GO:0008654]; response to fatty acid [GO:0070542]; response to nutrient [GO:0007584]; response to starvation [GO:0042594]; response to xenobiotic stimulus [GO:0009410]; synapse assembly [GO:0007416]; triglyceride biosynthetic process [GO:0019432] | cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; plasma membrane [GO:0005886] | glycerol-3-phosphate O-acyltransferase activity [GO:0004366]; glycerone-phosphate O-acyltransferase activity [GO:0016287] | 4464.10842458559 | -0.44283121926612 | 0.00392803961169972 | 0.0218118886733898 |
| P16278 | P16278 | BGAL_HUMAN | Beta-galactosidase (EC 3.2.1.23) (Acid beta-galactosidase) (Lactase) (Elastin receptor 1) | GLB1 | carbohydrate metabolic process [GO:0005975]; galactose catabolic process [GO:0019388]; glycosphingolipid catabolic process [GO:0046479]; heparan sulfate proteoglycan catabolic process [GO:0030200]; keratan sulfate catabolic process [GO:0042340]; response to cortisone [GO:0051413]; response to Thyroglobulin triiodothyronine [GO:1904016] | azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; perinuclear region of cytoplasm [GO:0048471]; vacuole [GO:0005773] | beta-galactosidase activity [GO:0004565]; galactoside binding [GO:0016936]; protein homodimerization activity [GO:0042803] | 138858.58375465398 | -0.16981256436616 | 0.00405017853536802 | 0.0224323671372387 |
| Q5VW38 | Q5VW38 | GP107_HUMAN | Protein GPR107 (Lung seven transmembrane receptor 1) | GPR107 | clathrin-dependent endocytosis [GO:0072583] | clathrin-coated vesicle [GO:0030136]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] | clathrin heavy chain binding [GO:0032050] | 11486.392360319049 | 0.3962790532719 | 0.00415940633588546 | 0.0230148401358662 |
| Q9NP72 | Q9NP72 | RAB18_HUMAN | Ras-related protein Rab-18 | RAB18 | brain development [GO:0007420]; endoplasmic reticulum tubular network organization [GO:0071786]; eye development [GO:0001654]; intracellular protein transport [GO:0006886]; lipid droplet organization [GO:0034389]; small GTPase-mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] | apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] | GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] | 98264.76064334274 | 0.29169984317843 | 0.00418616015890934 | 0.0231402765467125 |
| Q9BVC6 | Q9BVC6 | TM109_HUMAN | Voltage-gated monoatomic cation channel TMEM109 (Mitsugumin-23) (Mg23) (Transmembrane protein 109) | TMEM109 | cellular response to gamma radiation [GO:0071480]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of programmed cell death [GO:0043069] | extracellular exosome [GO:0070062]; monoatomic ion channel complex [GO:0034702]; nuclear outer membrane [GO:0005640]; sarcoplasmic reticulum membrane [GO:0033017] | voltage-gated monoatomic cation channel activity [GO:0022843] | 156968.1445377565 | -0.397638987050636 | 0.00421708035941971 | 0.0232884769166394 |
| P09622 | P09622 | DLDH_HUMAN | Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein) | DLD | acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; branched-chain amino acid catabolic process [GO:0009083]; gastrulation [GO:0007369]; histone succinylation [GO:0106077]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; proteolysis [GO:0006508]; regulation of membrane potential [GO:0042391]; sperm capacitation [GO:0048240] | acetyltransferase complex [GO:1902493]; acrosomal matrix [GO:0043159]; mitochondrial matrix [GO:0005759]; mitochondrial pyruvate dehydrogenase complex [GO:0005967]; mitochondrion [GO:0005739]; motile cilium [GO:0031514]; nucleus [GO:0005634]; oxoglutarate dehydrogenase complex [GO:0045252]; pyruvate dehydrogenase complex [GO:0045254] | dihydrolipoyl dehydrogenase activity [GO:0004148]; flavin adenine dinucleotide binding [GO:0050660] | 37797.5787140446 | 0.322234986942268 | 0.00426154181947818 | 0.0234882256314819 |
| P14625 | P14625 | ENPL_HUMAN | Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | HSP90B1 | actin rod assembly [GO:0031247]; cellular response to ATP [GO:0071318]; cellular response to manganese ion [GO:0071287]; DNA damage response [GO:0006974]; ERAD pathway [GO:0036503]; negative regulation of apoptotic process [GO:0043066]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; protein transport [GO:0015031]; regulation of phosphoprotein phosphatase activity [GO:0043666]; response to endoplasmic reticulum stress [GO:0034976]; response to heat [GO:0009408]; response to hypoxia [GO:0001666]; retrograde protein transport, ER to cytosol [GO:0030970]; sequestering of calcium ion [GO:0051208] | collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; sarcoplasmic reticulum lumen [GO:0033018]; smooth endoplasmic reticulum [GO:0005790]; sperm plasma membrane [GO:0097524] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; calcium ion binding [GO:0005509]; low-density lipoprotein particle receptor binding [GO:0050750]; protein phosphatase binding [GO:0019903]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082] | 313353.66602456453 | 0.187686538631419 | 0.00426010018252414 | 0.0234882256314819 |
| P61769 | P61769 | B2MG_HUMAN | Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3] | B2M | amyloid fibril formation [GO:1990000]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent [GO:0002481]; cellular response to iron ion [GO:0071281]; cellular response to iron(III) ion [GO:0071283]; cellular response to nicotine [GO:0071316]; intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]; learning or memory [GO:0007611]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of forebrain neuron differentiation [GO:2000978]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron projection development [GO:0010977]; negative regulation of receptor binding [GO:1900121]; peptide antigen assembly with MHC class I protein complex [GO:0002502]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of cellular senescence [GO:2000774]; positive regulation of ferrous iron binding [GO:1904434]; positive regulation of immune response [GO:0050778]; positive regulation of protein binding [GO:0032092]; positive regulation of receptor binding [GO:1900122]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of transferrin receptor binding [GO:1904437]; protein homotetramerization [GO:0051289]; protein refolding [GO:0042026]; regulation of erythrocyte differentiation [GO:0045646]; regulation of iron ion transport [GO:0034756]; response to molecule of bacterial origin [GO:0002237]; sensory perception of smell [GO:0007608]; T cell differentiation in thymus [GO:0033077]; T cell mediated cytotoxicity [GO:0001913] | cytosol [GO:0005829]; early endosome lumen [GO:0031905]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; HFE-transferrin receptor complex [GO:1990712]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; MHC class I peptide loading complex [GO:0042824]; MHC class I protein complex [GO:0042612]; MHC class II protein complex [GO:0042613]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] | identical protein binding [GO:0042802]; MHC class II protein complex binding [GO:0023026]; peptide antigen binding [GO:0042605]; protein homodimerization activity [GO:0042803]; structural molecule activity [GO:0005198] | 132930.05027823604 | 0.552549077641973 | 0.00433102223512667 | 0.0238448624147115 |
| O75122 | O75122 | CLAP2_HUMAN | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | CLASP2 | cell division [GO:0051301]; establishment of mitotic spindle localization [GO:0040001]; establishment or maintenance of cell polarity [GO:0007163]; exit from mitosis [GO:0010458]; Golgi organization [GO:0007030]; microtubule anchoring [GO:0034453]; microtubule cytoskeleton organization [GO:0000226]; microtubule nucleation [GO:0007020]; microtubule organizing center organization [GO:0031023]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of wound healing, spreading of epidermal cells [GO:1903690]; platelet-derived growth factor receptor-beta signaling pathway [GO:0035791]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of exocytosis [GO:0045921]; positive regulation of extracellular matrix disassembly [GO:0090091]; protein localization to plasma membrane [GO:0072659]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of axon extension [GO:0030516]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gastrulation [GO:0010470]; regulation of microtubule polymerization [GO:0031113]; regulation of microtubule polymerization or depolymerization [GO:0031110]; regulation of microtubule-based process [GO:0032886]; vesicle targeting [GO:0006903] | axonal growth cone [GO:0044295]; basal cortex [GO:0045180]; cell cortex [GO:0005938]; cell leading edge [GO:0031252]; centrosome [GO:0005813]; cortical microtubule plus-end [GO:1903754]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; spindle microtubule [GO:0005876]; trans-Golgi network [GO:0005802] | actin filament binding [GO:0051015]; dystroglycan binding [GO:0002162]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; protein tyrosine kinase binding [GO:1990782] | 7148.13301675674 | -0.366769787514389 | 0.00434222800262929 | 0.0238448624147115 |
| Q9UJU6 | Q9UJU6 | DBNL_HUMAN | Drebrin-like protein (Cervical SH3P7) (Cervical mucin-associated protein) (Drebrin-F) (HPK1-interacting protein of 55 kDa) (HIP-55) (SH3 domain-containing protein 7) | DBNL | adaptive immune response [GO:0002250]; endocytosis [GO:0006897]; membrane organization [GO:0061024]; neuron projection morphogenesis [GO:0048812]; podosome assembly [GO:0071800]; positive regulation of axon extension [GO:0045773]; positive regulation of dendritic spine morphogenesis [GO:0061003]; Rac protein signal transduction [GO:0016601]; regulation of actin filament polymerization [GO:0030833]; synapse assembly [GO:0007416] | actin filament [GO:0005884]; anchoring junction [GO:0070161]; cell cortex [GO:0005938]; clathrin-coated vesicle membrane [GO:0030665]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; podosome [GO:0002102]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; ruffle [GO:0001726]; secretory granule lumen [GO:0034774]; site of polarized growth [GO:0030427]; tertiary granule lumen [GO:1904724] | actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; enzyme activator activity [GO:0008047]; protein domain specific binding [GO:0019904]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973] | 97211.53933190335 | 0.108987714854456 | 0.00434013739507175 | 0.0238448624147115 |
| O60927 | O60927 | PP1RB_HUMAN | E3 ubiquitin-protein ligase PPP1R11 (EC 2.3.2.27) (Hemochromatosis candidate gene V protein) (HCG V) (Protein phosphatase 1 regulatory subunit 11) (Protein phosphatase inhibitor 3) | PPP1R11 | defense response to Gram-positive bacterium [GO:0050830]; negative regulation of cytokine production [GO:0001818]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] | cytoplasm [GO:0005737]; nucleus [GO:0005634] | phosphatase binding [GO:0019902]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase inhibitor activity [GO:0004864]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; ubiquitin protein ligase activity [GO:0061630] | 11022.733295398306 | 0.735939857589152 | 0.00434308118813666 | 0.0238448624147115 |
| Q9UBN6 | Q9UBN6 | TR10D_HUMAN | Tumor necrosis factor receptor superfamily member 10D (Decoy receptor 2) (DcR2) (TNF-related apoptosis-inducing ligand receptor 4) (TRAIL receptor 4) (TRAIL-R4) (TRAIL receptor with a truncated death domain) (CD antigen CD264) | TNFRSF10D | negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; signal transduction [GO:0007165]; TRAIL-activated apoptotic signaling pathway [GO:0036462] | cell surface [GO:0009986]; plasma membrane [GO:0005886] | TRAIL binding [GO:0045569]; transmembrane signaling receptor activity [GO:0004888] | 21708.3434049497 | 0.549977889187257 | 0.00435235518240076 | 0.0238726471088893 |
| Q9H3N1 | Q9H3N1 | TMX1_HUMAN | Thioredoxin-related transmembrane protein 1 (Protein disulfide-isomerase TMX1) (EC 5.3.4.1) (Thioredoxin domain-containing protein 1) (Transmembrane Trx-related protein) | TMX1 | negative regulation of platelet aggregation [GO:0090331]; negative regulation of triglyceride biosynthetic process [GO:0010868]; positive regulation of ERAD pathway [GO:1904294]; regulation of calcium ion transport [GO:0051924]; response to endoplasmic reticulum stress [GO:0034976] | endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrial membrane [GO:0031966] | disulfide oxidoreductase activity [GO:0015036]; enzyme inhibitor activity [GO:0004857]; protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035] | 42910.76917330365 | 0.329217527202952 | 0.00436477186869985 | 0.0239175990406705 |
| Q96SL4 | Q96SL4 | GPX7_HUMAN | Glutathione peroxidase 7 (GPx-7) (GSHPx-7) (EC 1.11.1.9) (CL683) | GPX7 | cellular response to oxidative stress [GO:0034599] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576] | catalase activity [GO:0004096]; glutathione peroxidase activity [GO:0004602]; peroxidase activity [GO:0004601] | 36025.68966480575 | -0.430214718853843 | 0.00437778296006719 | 0.0239425851850779 |
| Q96GA7 | Q96GA7 | SDSL_HUMAN | Serine dehydratase-like (L-serine deaminase) (L-serine dehydratase/L-threonine deaminase) (SDHL) (L-threonine dehydratase) (TDH) (EC 4.3.1.19) (Serine dehydratase 2) (SDH 2) (EC 4.3.1.17) | SDSL | isoleucine biosynthetic process [GO:0009097]; L-serine catabolic process [GO:0006565]; lipid metabolic process [GO:0006629]; threonine catabolic process [GO:0006567] | cytosol [GO:0005829] | identical protein binding [GO:0042802]; L-serine ammonia-lyase activity [GO:0003941]; pyridoxal phosphate binding [GO:0030170]; threonine deaminase activity [GO:0004794] | 3943.949931316515 | -0.936791208907337 | 0.00437369406398233 | 0.0239425851850779 |
| P11802 | P11802 | CDK4_HUMAN | Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3) | CDK4 | cell division [GO:0051301]; cellular response to interleukin-4 [GO:0071353]; cellular response to ionomycin [GO:1904637]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; G1/S transition of mitotic cell cycle [GO:0000082]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of gene expression [GO:0010468]; regulation of transcription initiation by RNA polymerase II [GO:0060260]; regulation of type B pancreatic cell proliferation [GO:0061469]; response to organic substance [GO:0010033]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165] | bicellular tight junction [GO:0005923]; chromatin [GO:0000785]; cyclin D1-CDK4 complex [GO:0097128]; cyclin D2-CDK4 complex [GO:0097129]; cyclin D3-CDK4 complex [GO:0097130]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] | ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; protein serine kinase activity [GO:0106310] | 10135.21034977622 | -0.351693822313901 | 0.00438450207569228 | 0.023956209026878 |
| Q92688 | Q92688 | AN32B_HUMAN | Acidic leucine-rich nuclear phosphoprotein 32 family member B (Acidic protein rich in leucines) (Putative HLA-DR-associated protein I-2) (PHAPI2) (Silver-stainable protein SSP29) | ANP32B | activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; inner ear development [GO:0048839]; negative regulation of cell differentiation [GO:0045596]; nucleosome assembly [GO:0006334]; positive regulation of protein export from nucleus [GO:0046827]; regulation of apoptotic process [GO:0042981]; roof of mouth development [GO:0060021]; vasculature development [GO:0001944]; ventricular system development [GO:0021591] | cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | histone binding [GO:0042393]; RNA polymerase binding [GO:0070063] | 90956.0541200852 | 0.2898257111365 | 0.00439108604820742 | 0.0239690689298104 |
| P55039 | P55039 | DRG2_HUMAN | Developmentally-regulated GTP-binding protein 2 (DRG-2) (Translation factor GTPase DRG2) (TRAFAC GTPase DRG2) (EC 3.6.5.-) | DRG2 | cytoplasmic translation [GO:0002181]; signal transduction [GO:0007165] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] | 15364.722239388 | -0.17939925566207 | 0.00440519457031724 | 0.0240229378589196 |
| Q9UMX0 | Q9UMX0 | UBQL1_HUMAN | Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1) | UBQLN1 | aggrephagy [GO:0035973]; autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; cellular response to hypoxia [GO:0071456]; ERAD pathway [GO:0036503]; macroautophagy [GO:0016236]; negative regulation of store-operated calcium channel activity [GO:1901340]; negative regulation of toll-like receptor 3 signaling pathway [GO:0034140]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of protein ubiquitination [GO:0031398]; regulation of macroautophagy [GO:0016241]; regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902175]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of protein ubiquitination [GO:0031396]; response to endoplasmic reticulum stress [GO:0034976]; ubiquitin-dependent protein catabolic process [GO:0006511] | aggresome [GO:0016235]; autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; proteasome complex [GO:0000502]; protein-containing complex [GO:0032991] | identical protein binding [GO:0042802]; kinase binding [GO:0019900]; polyubiquitin modification-dependent protein binding [GO:0031593] | 50122.8517998692 | 0.290727674185348 | 0.00443060242379199 | 0.0241382628203898 |
| P55036 | P55036 | PSMD4_HUMAN | 26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein) | PSMD4 | proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] | cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540] | identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; polyubiquitin modification-dependent protein binding [GO:0031593]; RNA binding [GO:0003723] | 74076.5914212298 | 0.204206191995876 | 0.00444736832329986 | 0.0241830987714175 |
| P61026 | P61026 | RAB10_HUMAN | Ras-related protein Rab-10 (EC 3.6.5.2) | RAB10 | antigen processing and presentation [GO:0019882]; axonogenesis [GO:0007409]; cellular response to insulin stimulus [GO:0032869]; endoplasmic reticulum tubular network organization [GO:0071786]; endosomal transport [GO:0016197]; establishment of neuroblast polarity [GO:0045200]; establishment of protein localization to endoplasmic reticulum membrane [GO:0097051]; establishment of protein localization to membrane [GO:0090150]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi to plasma membrane transport [GO:0006893]; polarized epithelial cell differentiation [GO:0030859]; protein localization to basolateral plasma membrane [GO:1903361]; protein localization to plasma membrane [GO:0072659]; regulated exocytosis [GO:0045055]; vesicle-mediated transport [GO:0016192] | adherens junction [GO:0005912]; cilium [GO:0005929]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; endosome [GO:0005768]; endosome membrane [GO:0010008]; exocytic vesicle [GO:0070382]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; insulin-responsive compartment [GO:0032593]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; secretory granule membrane [GO:0030667]; trans-Golgi network [GO:0005802] | cadherin binding involved in cell-cell adhesion [GO:0098641]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; myosin V binding [GO:0031489] | 58271.78525807215 | 0.308137283535152 | 0.00444475042862329 | 0.0241830987714175 |
| Q9UKZ9 | Q9UKZ9 | PCOC2_HUMAN | Procollagen C-endopeptidase enhancer 2 (Procollagen COOH-terminal proteinase enhancer 2) (PCPE-2) (Procollagen C-proteinase enhancer 2) | PCOLCE2 | cellular response to leukemia inhibitory factor [GO:1990830] | collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576] | collagen binding [GO:0005518]; heparin binding [GO:0008201]; peptidase activator activity [GO:0016504] | 10139.444866655936 | -0.23551457387911 | 0.00455280968559447 | 0.0247327130187711 |
| O60884 | O60884 | DNJA2_HUMAN | DnaJ homolog subfamily A member 2 (Cell cycle progression restoration gene 3 protein) (Dnj3) (Dj3) (HIRA-interacting protein 4) (Renal carcinoma antigen NY-REN-14) | DNAJA2 | positive regulation of cell population proliferation [GO:0008284]; protein refolding [GO:0042026]; response to heat [GO:0009408] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020] | ATP binding [GO:0005524]; ATPase activator activity [GO:0001671]; Hsp70 protein binding [GO:0030544]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] | 27615.97310241765 | 0.20390571706452 | 0.00460550261438673 | 0.0249611224629069 |
| P54619 | P54619 | AAKG1_HUMAN | 5'-AMP-activated protein kinase subunit gamma-1 (AMPK gamma1) (AMPK subunit gamma-1) (AMPKg) | PRKAG1 | cellular response to nutrient levels [GO:0031669]; fatty acid biosynthetic process [GO:0006633]; import into nucleus [GO:0051170]; positive regulation of gene expression [GO:0010628]; positive regulation of protein kinase activity [GO:0045860]; protein phosphorylation [GO:0006468]; regulation of glycolytic process [GO:0006110]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634] | ADP binding [GO:0043531]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; cAMP-dependent protein kinase regulator activity [GO:0008603]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887] | 16028.91569697505 | -0.199282282579583 | 0.00460807167246747 | 0.0249611224629069 |
| Q8WVC6 | Q8WVC6 | DCAKD_HUMAN | Dephospho-CoA kinase domain-containing protein | DCAKD | coenzyme A biosynthetic process [GO:0015937] | membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741] | ATP binding [GO:0005524]; dephospho-CoA kinase activity [GO:0004140] | 7185.382339592241 | -1.14881855456723 | 0.00464706797836585 | 0.0251483162993514 |
| Q8IZ81 | Q8IZ81 | ELMD2_HUMAN | ELMO domain-containing protein 2 | ELMOD2 | defense response to virus [GO:0051607]; regulation of defense response to virus [GO:0050688] | membrane [GO:0016020] | GTPase activator activity [GO:0005096] | 23649.7973183597 | -0.209858431137159 | 0.00466001273002217 | 0.0251943054659405 |
| Q96IP4 | Q96IP4 | TET5A_HUMAN | Terminal nucleotidyltransferase 5A (EC 2.7.7.19) (HBV X-transactivated gene 11 protein) (HBV XAg-transactivated protein 11) | TENT5A | mRNA stabilization [GO:0048255]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of ossification [GO:0030278]; response to bacterium [GO:0009617] | cytoplasm [GO:0005737] | poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723] | 6422.86552685033 | -0.530265204470882 | 0.00467176904610858 | 0.0252337878124416 |
| O95379 | O95379 | TFIP8_HUMAN | Tumor necrosis factor alpha-induced protein 8 (TNF alpha-induced protein 8) (Head and neck tumor and metastasis-related protein) (MDC-3.13) (NF-kappa-B-inducible DED-containing protein) (NDED) (SCC-S2) (TNF-induced protein GG2-1) | TNFAIP8 | apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065] | cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] | cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027] | 19270.195406279352 | 0.488305896687078 | 0.00472762108269152 | 0.0255111438614573 |
| O43924 | O43924 | PDE6D_HUMAN | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta) (Protein p17) | PDE6D | response to stimulus [GO:0050896]; visual perception [GO:0007601] | cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829] | GTPase inhibitor activity [GO:0005095]; small GTPase binding [GO:0031267] | 13834.3878615715 | -0.671315102520241 | 0.00473526577142454 | 0.0255280835974229 |
| P61966 | P61966 | AP1S1_HUMAN | AP-1 complex subunit sigma-1A (Adaptor protein complex AP-1 subunit sigma-1A) (Adaptor-related protein complex 1 subunit sigma-1A) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin) (Sigma-adaptin 1A) (Sigma1A-adaptin) | AP1S1 | basolateral protein secretion [GO:0110010]; intracellular protein transport [GO:0006886]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; receptor-mediated endocytosis [GO:0006898]; response to virus [GO:0009615]; vesicle-mediated transport [GO:0016192] | AP-1 adaptor complex [GO:0030121]; clathrin-coated pit [GO:0005905]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; trans-Golgi network membrane [GO:0032588] | clathrin adaptor activity [GO:0035615] | 23122.185394582 | -0.266287900722354 | 0.00487397664529374 | 0.026201092668154 |
| Q9H0R3 | Q9H0R3 | TM222_HUMAN | Transmembrane protein 222 | TMEM222 | regulation of ethylene-activated signaling pathway [GO:0010104]; response to ethylene [GO:0009723] | dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] | 3568.3375790224354 | -1.24730531510763 | 0.00489923500807857 | 0.0263119104794059 | |
| Q9Y4L1 | Q9Y4L1 | HYOU1_HUMAN | Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4) | HYOU1 | cellular response to hypoxia [GO:0071456]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endoplasmic reticulum unfolded protein response [GO:0030968]; negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903382]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; response to endoplasmic reticulum stress [GO:0034976]; response to ischemia [GO:0002931] | endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; membrane [GO:0016020]; smooth endoplasmic reticulum [GO:0005790] | adenyl-nucleotide exchange factor activity [GO:0000774]; ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] | 204232.27640032698 | 0.145334544856376 | 0.00490975595485756 | 0.0263434443562717 |
| Q9ULC3 | Q9ULC3 | RAB23_HUMAN | Ras-related protein Rab-23 | RAB23 | autophagosome assembly [GO:0000045]; cellular defense response [GO:0006968]; cilium assembly [GO:0060271]; craniofacial suture morphogenesis [GO:0097094]; GTP metabolic process [GO:0046039]; intracellular protein transport [GO:0006886]; negative regulation of protein import into nucleus [GO:0042308]; vesicle-mediated transport [GO:0016192] | autophagosome [GO:0005776]; cell junction [GO:0030054]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endosome membrane [GO:0010008]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886] | GTP binding [GO:0005525]; GTPase activity [GO:0003924] | 33886.146121041806 | 0.238432519979048 | 0.00496235596845479 | 0.0266004814732874 |
| Q14249 | Q14249 | NUCG_HUMAN | Endonuclease G, mitochondrial (Endo G) (EC 3.1.30.-) | ENDOG | apoptotic DNA fragmentation [GO:0006309]; DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; in utero embryonic development [GO:0001701]; mitochondrial DNA catabolic process [GO:0032043]; negative regulation of TOR signaling [GO:0032007]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of mitochondrial DNA replication [GO:0090297]; response to antibiotic [GO:0046677]; response to tumor necrosis factor [GO:0034612] | mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634] | DNA endonuclease activity [GO:0004520]; magnesium ion binding [GO:0000287]; nucleic acid binding [GO:0003676]; protein homodimerization activity [GO:0042803]; RNA endonuclease activity [GO:0004521]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014] | 10996.06543038405 | 0.481820163448652 | 0.00499784187983524 | 0.0267653800483426 |
| Q16864 | Q16864 | VATF_HUMAN | V-type proton ATPase subunit F (V-ATPase subunit F) (V-ATPase 14 kDa subunit) (Vacuolar proton pump subunit F) | ATP6V1F | endosomal lumen acidification [GO:0048388]; Golgi lumen acidification [GO:0061795]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; proton transmembrane transport [GO:1902600]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035] | clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; synaptic vesicle membrane [GO:0030672]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221] | ATPase-coupled ion transmembrane transporter activity [GO:0042625]; proton transmembrane transporter activity [GO:0015078]; proton-transporting ATPase activity, rotational mechanism [GO:0046961] | 17202.67877420085 | -0.467758846141402 | 0.00500930465150867 | 0.0267761510900454 |
| Q86WN1 | Q86WN1 | FCSD1_HUMAN | F-BAR and double SH3 domains protein 1 (Protein nervous wreck 2) (NWK2) | FCHSD1 | membrane organization [GO:0061024]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of actin filament polymerization [GO:0030838]; regulation of actin filament polymerization [GO:0030833] | cell projection [GO:0042995]; cuticular plate [GO:0032437]; neuromuscular junction [GO:0031594]; perikaryon [GO:0043204]; recycling endosome [GO:0055037] | lipid binding [GO:0008289] | 5199.30902301507 | -0.395401653026818 | 0.00500874306110831 | 0.0267761510900454 |
| Q9H6X2 | Q9H6X2 | ANTR1_HUMAN | Anthrax toxin receptor 1 (Tumor endothelial marker 8) | ANTXR1 | actin cytoskeleton organization [GO:0030036]; blood vessel development [GO:0001568]; negative regulation of extracellular matrix assembly [GO:1901202]; reproductive process [GO:0022414]; substrate adhesion-dependent cell spreading [GO:0034446] | cell surface [GO:0009986]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; filopodium membrane [GO:0031527]; lamellipodium membrane [GO:0031258]; plasma membrane [GO:0005886] | actin filament binding [GO:0051015]; collagen binding [GO:0005518]; metal ion binding [GO:0046872]; transmembrane signaling receptor activity [GO:0004888] | 13269.958574998102 | -0.245270415407489 | 0.00507917059903825 | 0.0270813551482299 |
| P55822 | P55822 | SH3BG_HUMAN | SH3 domain-binding glutamic acid-rich protein (SH3BGR protein) (21-glutamic acid-rich protein) (21-GARP) | SH3BGR | cytoplasm [GO:0005737] | SH3 domain binding [GO:0017124] | 8222.13089971499 | -0.918631290841493 | 0.00508074135590689 | 0.0270813551482299 | |
| P33897 | P33897 | ABCD1_HUMAN | ATP-binding cassette sub-family D member 1 (EC 3.1.2.-) (EC 7.6.2.-) (Adrenoleukodystrophy protein) (ALDP) | ABCD1 | alpha-linolenic acid metabolic process [GO:0036109]; fatty acid beta-oxidation [GO:0006635]; fatty acid elongation [GO:0030497]; fatty acid homeostasis [GO:0055089]; linoleic acid metabolic process [GO:0043651]; long-chain fatty acid catabolic process [GO:0042758]; long-chain fatty acid import into peroxisome [GO:0015910]; myelin maintenance [GO:0043217]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neuron projection maintenance [GO:1990535]; peroxisomal membrane transport [GO:0015919]; peroxisome organization [GO:0007031]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of unsaturated fatty acid biosynthetic process [GO:2001280]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of fatty acid beta-oxidation [GO:0031998]; regulation of mitochondrial depolarization [GO:0051900]; regulation of oxidative phosphorylation [GO:0002082]; sterol homeostasis [GO:0055092]; very long-chain fatty acid catabolic process [GO:0042760]; very long-chain fatty acid metabolic process [GO:0000038]; very long-chain fatty-acyl-CoA catabolic process [GO:0036113] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] | ABC-type fatty-acyl-CoA transporter activity [GO:0015607]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; enzyme binding [GO:0019899]; fatty acyl-CoA hydrolase activity [GO:0047617]; identical protein binding [GO:0042802]; long-chain fatty acid transporter activity [GO:0005324]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; very long-chain fatty acyl-CoA hydrolase activity [GO:0052817] | 4925.59857915013 | -0.930277962194086 | 0.00518971224435703 | 0.0276361932110216 |
| Q9H792 | Q9H792 | PEAK1_HUMAN | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | PEAK1 | cell migration [GO:0016477]; focal adhesion assembly [GO:0048041]; protein autophosphorylation [GO:0046777]; regulation of focal adhesion assembly [GO:0051893]; substrate adhesion-dependent cell spreading [GO:0034446] | actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; focal adhesion [GO:0005925] | identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase activity [GO:0004672] | 10724.482767447349 | -0.229754622541577 | 0.00520164242836897 | 0.0276526124614038 |
| P46937 | P46937 | YAP1_HUMAN | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | YAP1 | bud elongation involved in lung branching [GO:0060449]; canonical Wnt signaling pathway [GO:0060070]; cardiac muscle tissue regeneration [GO:0061026]; cell morphogenesis [GO:0000902]; cellular response to gamma radiation [GO:0071480]; cellular response to retinoic acid [GO:0071300]; DNA damage response [GO:0006974]; embryonic heart tube morphogenesis [GO:0003143]; enterocyte differentiation [GO:1903703]; epithelial cell proliferation [GO:0050673]; extrinsic apoptotic signaling pathway [GO:0097191]; glandular epithelial cell differentiation [GO:0002067]; heart process [GO:0003015]; hippo signaling [GO:0035329]; interleukin-6-mediated signaling pathway [GO:0070102]; intestinal epithelial cell development [GO:0060576]; keratinocyte differentiation [GO:0030216]; lateral mesoderm development [GO:0048368]; lung epithelial cell differentiation [GO:0060487]; negative regulation of cilium assembly [GO:1902018]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription by RNA polymerase II [GO:0000122]; notochord development [GO:0030903]; organ growth [GO:0035265]; paraxial mesoderm development [GO:0048339]; polarized epithelial cell differentiation [GO:0030859]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell growth [GO:0030307]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of keratinocyte proliferation [GO:0010837]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]; regulation of neurogenesis [GO:0050767]; regulation of stem cell proliferation [GO:0072091]; response to progesterone [GO:0032570]; somatic stem cell population maintenance [GO:0035019]; tissue homeostasis [GO:0001894]; trophectodermal cell differentiation [GO:0001829]; vasculogenesis [GO:0001570]; wound healing [GO:0042060] | cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; female germ cell nucleus [GO:0001674]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TEAD-YAP complex [GO:0140552] | chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; proline-rich region binding [GO:0070064]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] | 34845.68059049955 | 0.264357569364151 | 0.00520255645673429 | 0.0276526124614038 |
| Q53HC0 | Q53HC0 | CCD92_HUMAN | Coiled-coil domain-containing protein 92 (Limkain beta-2) | CCDC92 | innate immune response [GO:0045087]; regulation of defense response to virus [GO:0050688] | centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] | identical protein binding [GO:0042802] | 6032.304351498609 | 0.896581041405864 | 0.00524661052762351 | 0.0278419811947184 |
| O95373 | O95373 | IPO7_HUMAN | Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7) | IPO7 | innate immune response [GO:0045087]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of odontoblast differentiation [GO:1901331]; positive regulation of protein localization to nucleus [GO:1900182]; protein import into nucleus [GO:0006606] | cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654] | GTPase regulator activity [GO:0030695]; histone binding [GO:0042393]; SMAD binding [GO:0046332]; small GTPase binding [GO:0031267] | 13559.170110006551 | -0.292630057799827 | 0.0052526237781811 | 0.0278419811947184 |
| P23919 | P23919 | KTHY_HUMAN | Thymidylate kinase (EC 2.7.4.9) (dTMP kinase) | DTYMK | cellular response to growth factor stimulus [GO:0071363]; dTDP biosynthetic process [GO:0006233]; dTTP biosynthetic process [GO:0006235]; dUDP biosynthetic process [GO:0006227]; myoblast differentiation [GO:0045445]; phosphorylation [GO:0016310]; response to cadmium ion [GO:0046686]; response to estrogen [GO:0043627]; thymidine biosynthetic process [GO:0046105] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634] | ATP binding [GO:0005524]; nucleoside diphosphate kinase activity [GO:0004550]; thymidylate kinase activity [GO:0004798] | 16379.8969819464 | -0.204220080417412 | 0.00528875666942378 | 0.0280056965317338 |
| Q92841 | Q92841 | DDX17_HUMAN | Probable ATP-dependent RNA helicase DDX17 (EC 3.6.4.13) (DEAD box protein 17) (DEAD box protein p72) (DEAD box protein p82) (RNA-dependent helicase p72) | DDX17 | alternative mRNA splicing, via spliceosome [GO:0000380]; androgen receptor signaling pathway [GO:0030521]; defense response to virus [GO:0051607]; epithelial to mesenchymal transition [GO:0001837]; immune system process [GO:0002376]; intracellular estrogen receptor signaling pathway [GO:0030520]; miRNA metabolic process [GO:0010586]; myoblast differentiation [GO:0045445]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of skeletal muscle cell differentiation [GO:2001014]; regulation of transcription by RNA polymerase II [GO:0006357]; regulatory ncRNA-mediated gene silencing [GO:0031047]; RNA processing [GO:0006396]; rRNA processing [GO:0006364] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on RNA [GO:0008186]; mRNA 3'-UTR binding [GO:0003730]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; transcription coactivator activity [GO:0003713] | 39117.0071074171 | -0.159571834504941 | 0.00531145362484112 | 0.0280996230049952 |
| Q9ULC4 | Q9ULC4 | MCTS1_HUMAN | Malignant T-cell-amplified sequence 1 (MCT-1) (Multiple copies T-cell malignancies) | MCTS1 | cell cycle [GO:0007049]; DNA damage response [GO:0006974]; formation of translation preinitiation complex [GO:0001731]; IRES-dependent viral translational initiation [GO:0075522]; positive regulation of cell population proliferation [GO:0008284]; ribosome disassembly [GO:0032790] | cytoplasm [GO:0005737] | RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] | 44804.19666291565 | -0.703596850133687 | 0.00532583823243008 | 0.0281494397620791 |
| O95684 | O95684 | CEP43_HUMAN | Centrosomal protein 43 (FGFR1 oncogene partner) | CEP43 | cell projection organization [GO:0030030]; microtubule anchoring [GO:0034453]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284] | cell projection [GO:0042995]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] | protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein tyrosine kinase inhibitor activity [GO:0030292] | 9602.521448894611 | 0.663821818594867 | 0.00533223207686961 | 0.0281569682642528 |
| Q8TDQ7 | Q8TDQ7 | GNPI2_HUMAN | Glucosamine-6-phosphate isomerase 2 (EC 3.5.99.6) (Glucosamine-6-phosphate deaminase 2) (GNPDA 2) (GlcN6P deaminase 2) (Glucosamine-6-phosphate isomerase SB52) | GNPDA2 | carbohydrate metabolic process [GO:0005975]; glucosamine catabolic process [GO:0006043]; N-acetylglucosamine catabolic process [GO:0006046]; N-acetylneuraminate catabolic process [GO:0019262]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] | glucosamine-6-phosphate deaminase activity [GO:0004342]; identical protein binding [GO:0042802]; isomerase activity [GO:0016853] | 22805.6975446092 | 0.23225846373216 | 0.00535564103877553 | 0.028227964768095 |
| Q9BW91 | Q9BW91 | NUDT9_HUMAN | ADP-ribose pyrophosphatase, mitochondrial (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (Nucleoside diphosphate-linked moiety X motif 9) (Nudix motif 9) | NUDT9 | ADP catabolic process [GO:0046032]; nucleobase-containing small molecule metabolic process [GO:0055086] | cell junction [GO:0030054]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nuclear membrane [GO:0031965] | ADP-ribose diphosphatase activity [GO:0047631]; ADP-sugar diphosphatase activity [GO:0019144] | 15810.87284048075 | 0.326577649785711 | 0.00535427228340764 | 0.028227964768095 |
| O14558 | O14558 | HSPB6_HUMAN | Heat shock protein beta-6 (HspB6) (Heat shock 20 kDa-like protein p20) (Heat shock protein family B member 6) | HSPB6 | chaperone-mediated protein folding [GO:0061077]; negative regulation of apoptotic process [GO:0043066]; positive regulation of angiogenesis [GO:0045766]; protein refolding [GO:0042026]; response to heat [GO:0009408] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleus [GO:0005634] | protein folding chaperone [GO:0044183]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; structural constituent of eye lens [GO:0005212]; unfolded protein binding [GO:0051082] | 260000.61737732598 | -0.317136732387852 | 0.00537721853345577 | 0.0283153533555394 |
| P30043 | P30043 | BLVRB_HUMAN | Flavin reductase (NADPH) (FR) (EC 1.5.1.30) (Biliverdin reductase B) (BVR-B) (EC 1.3.1.-) (Biliverdin-IX beta-reductase) (Green heme-binding protein) (GHBP) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR) (S-nitroso-CoA-assisted nitrosyltransferase) (SNO-CoA-assisted nitrosyltransferase) (EC 2.6.99.-) | BLVRB | heme catabolic process [GO:0042167]; megakaryocyte differentiation [GO:0030219]; negative regulation of insulin receptor signaling pathway [GO:0046627] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] | biliberdin reductase NAD+ activity [GO:0106276]; biliverdin reductase (NAD(P)+) activity [GO:0004074]; biliverdin reductase (NADP+) activity [GO:0106277]; peptidyl-cysteine S-nitrosylase activity [GO:0035605]; riboflavin reductase (NADPH) activity [GO:0042602] | 78299.79805883695 | 0.269910857758203 | 0.00539632471686954 | 0.028363242899613 |
| Q8WZA9 | Q8WZA9 | IRGQ_HUMAN | Immunity-related GTPase family Q protein | IRGQ | GTP binding [GO:0005525] | 12792.719086810801 | 0.184273665920316 | 0.00539347193611569 | 0.028363242899613 | ||
| Q9BUF5 | Q9BUF5 | TBB6_HUMAN | Tubulin beta-6 chain (Tubulin beta class V) | TUBB6 | microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278] | cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleus [GO:0005634] | GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200] | 592140.1142199701 | 0.23112431272233 | 0.00546425797235474 | 0.0286936845888433 |
| P35244 | P35244 | RFA3_HUMAN | Replication protein A 14 kDa subunit (RP-A p14) (Replication factor A protein 3) (RF-A protein 3) | RPA3 | base-excision repair [GO:0006284]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; mismatch repair [GO:0006298]; nucleotide-excision repair [GO:0006289]; regulation of cell population proliferation [GO:0042127]; regulation of mitotic cell cycle [GO:0007346]; telomere maintenance [GO:0000723] | DNA replication factor A complex [GO:0005662]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861] | damaged DNA binding [GO:0003684]; single-stranded DNA binding [GO:0003697] | 13998.3384242493 | -0.49234515600905 | 0.00547096395563849 | 0.0287022979376367 |
| Q9UBC2 | Q9UBC2 | EP15R_HUMAN | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | EPS15L1 | endocytosis [GO:0006897]; endosomal transport [GO:0016197] | clathrin coat of coated pit [GO:0030132]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] | 22511.98539014465 | 0.198153054636091 | 0.00548868557544348 | 0.0287420447971005 |
| Q13287 | Q13287 | NMI_HUMAN | N-myc-interactor (Nmi) (N-myc and STAT interactor) | NMI | innate immune response [GO:0045087]; macrophage activation involved in immune response [GO:0002281]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of innate immune response [GO:0045824]; negative regulation of interferon-alpha production [GO:0032687]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of inflammatory response [GO:0050729]; positive regulation of innate immune response [GO:0045089]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; protein K48-linked ubiquitination [GO:0070936]; receptor signaling pathway via JAK-STAT [GO:0007259]; response to virus [GO:0009615]; toll-like receptor 4 signaling pathway [GO:0034142] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | identical protein binding [GO:0042802] | 11218.521035072601 | 0.430945474395692 | 0.0054846429477792 | 0.0287420447971005 |
| Q4ZHG4 | Q4ZHG4 | FNDC1_HUMAN | Fibronectin type III domain-containing protein 1 (Activation-associated cDNA protein) (Expressed in synovial lining protein) | FNDC1 | extracellular region [GO:0005576] | 454.19435287265355 | -5.34249744031387 | 0.00552126828732387 | 0.028869836651479 | ||
| P30613 | P30613 | KPYR_HUMAN | Pyruvate kinase PKLR (EC 2.7.1.40) (Pyruvate kinase 1) (Pyruvate kinase isozymes L/R) (R-type/L-type pyruvate kinase) (Red cell/liver pyruvate kinase) | PKLR | cellular response to epinephrine stimulus [GO:0071872]; cellular response to insulin stimulus [GO:0032869]; glycolytic process [GO:0006096]; phosphorylation [GO:0016310]; pyruvate biosynthetic process [GO:0042866]; response to ATP [GO:0033198]; response to cAMP [GO:0051591]; response to glucose [GO:0009749]; response to hypoxia [GO:0001666]; response to metal ion [GO:0010038]; response to nutrient [GO:0007584] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; pyruvate kinase complex [GO:1902912] | ATP binding [GO:0005524]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; monosaccharide binding [GO:0048029]; potassium ion binding [GO:0030955]; pyruvate kinase activity [GO:0004743] | 20181.0610104241 | -0.841083906320068 | 0.00552327972647427 | 0.028869836651479 |
| Q8N2K0 | Q8N2K0 | ABD12_HUMAN | Lysophosphatidylserine lipase ABHD12 (EC 3.1.-.-) (2-arachidonoylglycerol hydrolase ABHD12) (Abhydrolase domain-containing protein 12) (hABHD12) (Monoacylglycerol lipase ABHD12) (EC 3.1.1.23) (Oxidized phosphatidylserine lipase ABHD12) (EC 3.1.-.-) | ABHD12 | acylglycerol catabolic process [GO:0046464]; adult walking behavior [GO:0007628]; arachidonic acid metabolic process [GO:0019369]; glycerophospholipid catabolic process [GO:0046475]; monoacylglycerol catabolic process [GO:0052651]; phosphatidylserine catabolic process [GO:0006660]; phospholipid catabolic process [GO:0009395]; regulation of inflammatory response [GO:0050727]; response to auditory stimulus [GO:0010996] | AMPA glutamate receptor complex [GO:0032281]; dendrite cytoplasm [GO:0032839]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] | acylglycerol lipase activity [GO:0047372]; lysophospholipase activity [GO:0004622]; palmitoyl-(protein) hydrolase activity [GO:0008474]; phospholipase activity [GO:0004620] | 14405.57261563465 | 0.198460405187895 | 0.00572851558529189 | 0.0298599533636282 |
| Q969U7 | Q969U7 | PSMG2_HUMAN | Proteasome assembly chaperone 2 (PAC-2) (Hepatocellular carcinoma-susceptibility protein 3) (Tumor necrosis factor superfamily member 5-induced protein 1) | PSMG2 | chaperone-mediated protein complex assembly [GO:0051131]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of apoptotic process [GO:0043066]; proteasome assembly [GO:0043248] | cytosol [GO:0005829]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031] | molecular adaptor activity [GO:0060090] | 5065.95831585969 | -0.692419689340993 | 0.00575220591928617 | 0.0299558811936355 |
| Q15185 | Q15185 | TEBP_HUMAN | Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23) | PTGES3 | chaperone cofactor-dependent protein refolding [GO:0051085]; chaperone-mediated protein complex assembly [GO:0051131]; cyclooxygenase pathway [GO:0019371]; fibroblast proliferation [GO:0048144]; glucocorticoid receptor signaling pathway [GO:0042921]; glycogen biosynthetic process [GO:0005978]; lung saccule development [GO:0060430]; positive regulation of phosphorylation [GO:0042327]; positive regulation of telomerase activity [GO:0051973]; prostaglandin biosynthetic process [GO:0001516]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; signal transduction [GO:0007165]; skin development [GO:0043588]; telomerase holoenzyme complex assembly [GO:1905323]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004] | chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; protein-containing complex [GO:0032991]; telomerase holoenzyme complex [GO:0005697] | DNA polymerase binding [GO:0070182]; Hsp90 protein binding [GO:0051879]; prostaglandin-E synthase activity [GO:0050220]; protein-folding chaperone binding [GO:0051087]; telomerase activity [GO:0003720]; unfolded protein binding [GO:0051082] | 395085.49642771296 | 0.537772594539973 | 0.00576078079414571 | 0.029972988043737 |
| P13797 | P13797 | PLST_HUMAN | Plastin-3 (T-fimbrin) (T-plastin) | PLS3 | actin filament bundle assembly [GO:0051017]; actin filament network formation [GO:0051639]; bone development [GO:0060348] | actin filament [GO:0005884]; actin filament bundle [GO:0032432]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] | actin filament binding [GO:0051015]; calcium ion binding [GO:0005509] | 166401.00504699151 | -0.137817187441792 | 0.00582587864864686 | 0.0302838792873698 |
| Q6BCY4 | Q6BCY4 | NB5R2_HUMAN | NADH-cytochrome b5 reductase 2 (b5R.2) (EC 1.6.2.2) | CYB5R2 | bicarbonate transport [GO:0015701]; nitrate assimilation [GO:0042128]; nitric oxide biosynthetic process [GO:0006809]; sterol biosynthetic process [GO:0016126] | endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634] | cytochrome-b5 reductase activity, acting on NAD(P)H [GO:0004128]; FAD binding [GO:0071949]; nitrate reductase (NADH) activity [GO:0009703] | 5026.955182015756 | 0.721737325174629 | 0.00584163231703373 | 0.0303264593261495 |
| Q92871 | Q92871 | PMM1_HUMAN | Phosphomannomutase 1 (PMM 1) (EC 5.4.2.8) (PMMH-22) | PMM1 | cellular response to leukemia inhibitory factor [GO:1990830]; GDP-mannose biosynthetic process [GO:0009298]; mannose metabolic process [GO:0006013]; protein N-linked glycosylation [GO:0006487] | cytosol [GO:0005829]; neuronal cell body [GO:0043025] | metal ion binding [GO:0046872]; phosphomannomutase activity [GO:0004615] | 13884.29803470075 | -0.696232755031031 | 0.00584477472364194 | 0.0303264593261495 |
| Q9H0R4 | Q9H0R4 | HDHD2_HUMAN | Haloacid dehalogenase-like hydrolase domain-containing protein 2 | HDHD2 | dephosphorylation [GO:0016311] | extracellular exosome [GO:0070062] | alkaline phosphatase activity [GO:0004035]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; phosphoglycolate phosphatase activity [GO:0008967] | 5439.075543889565 | 0.415663363335826 | 0.00585371868881333 | 0.0303450778507011 |
| Q9BVT8 | Q9BVT8 | TMUB1_HUMAN | Transmembrane and ubiquitin-like domain-containing protein 1 (Dendritic cell-derived ubiquitin-like protein) (DULP) (Hepatocyte odd protein shuttling protein) (Ubiquitin-like protein SB144) [Cleaved into: iHOPS] | TMUB1 | ERAD pathway [GO:0036503] | centrosome [GO:0005813]; nucleolus [GO:0005730]; postsynaptic membrane [GO:0045211]; recycling endosome [GO:0055037] | 24433.3730776719 | -0.840309498742541 | 0.0058686585718274 | 0.0303947161498849 | |
| Q2M389 | Q2M389 | WASC4_HUMAN | WASH complex subunit 4 (Strumpellin and WASH-interacting protein) (SWIP) (WASH complex subunit SWIP) | WASHC4 | endosomal transport [GO:0016197]; endosome organization [GO:0007032]; nuclear envelope budding [GO:0140591]; protein transport [GO:0015031]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315] | early endosome membrane [GO:0031901]; endosome [GO:0005768]; nucleoplasm [GO:0005654]; WASH complex [GO:0071203] | 8504.40469759592 | -0.474420083559107 | 0.00591235930408316 | 0.0305930847643244 | |
| P38606 | P38606 | VATA_HUMAN | V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha) | ATP6V1A | cellular response to increased oxygen levels [GO:0036295]; endosomal lumen acidification [GO:0048388]; Golgi lumen acidification [GO:0061795]; intracellular iron ion homeostasis [GO:0006879]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035] | apical plasma membrane [GO:0016324]; clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extrinsic component of synaptic vesicle membrane [GO:0098850]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microvillus [GO:0005902]; nucleoplasm [GO:0005654]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; proton-transporting two-sector ATPase complex [GO:0016469]; proton-transporting V-type ATPase complex [GO:0033176]; secretory granule [GO:0030141]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton-transporting ATPase activity, rotational mechanism [GO:0046961] | 38144.542551373 | -0.196474292123603 | 0.00592832185982912 | 0.0306197553854073 |
| Q7Z3J2 | Q7Z3J2 | VP35L_HUMAN | VPS35 endosomal protein-sorting factor-like (Esophageal cancer-associated protein) | VPS35L | endocytic recycling [GO:0032456]; Golgi to plasma membrane transport [GO:0006893]; protein transport [GO:0015031] | endosome [GO:0005768]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886] | 7144.839464644931 | -0.493907159345923 | 0.00592302470566503 | 0.0306197553854073 | |
| P55209 | P55209 | NP1L1_HUMAN | Nucleosome assembly protein 1-like 1 (NAP-1-related protein) (hNRP) | NAP1L1 | DNA replication [GO:0006260]; nervous system development [GO:0007399]; nucleosome assembly [GO:0006334]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neurogenesis [GO:0050769] | chromatin [GO:0000785]; cytoplasm [GO:0005737]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleus [GO:0005634] | chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; RNA binding [GO:0003723] | 76087.09029661625 | 0.344982299328585 | 0.00600928247023463 | 0.0310096488855641 |
| Q14376 | Q14376 | GALE_HUMAN | UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-N-acetylgalactosamine 4-epimerase) (UDP-GalNAc 4-epimerase) (UDP-N-acetylglucosamine 4-epimerase) (UDP-GlcNAc 4-epimerase) (EC 5.1.3.7) (UDP-galactose 4-epimerase) | GALE | galactose catabolic process [GO:0019388]; galactose catabolic process via UDP-galactose [GO:0033499] | cytosol [GO:0005829] | identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; UDP-glucose 4-epimerase activity [GO:0003978]; UDP-N-acetylglucosamine 4-epimerase activity [GO:0003974] | 21841.728814336 | 0.234260922235866 | 0.00611184705706858 | 0.0315102142177894 |
| P34897 | P34897 | GLYM_HUMAN | Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) | SHMT2 | folic acid metabolic process [GO:0046655]; glycine biosynthetic process from serine [GO:0019264]; glycine metabolic process [GO:0006544]; L-serine biosynthetic process [GO:0006564]; L-serine catabolic process [GO:0006565]; L-serine metabolic process [GO:0006563]; one-carbon metabolic process [GO:0006730]; positive regulation of cell population proliferation [GO:0008284]; protein homotetramerization [GO:0051289]; protein K63-linked deubiquitination [GO:0070536]; protein tetramerization [GO:0051262]; regulation of aerobic respiration [GO:1903715]; regulation of mitochondrial translation [GO:0070129]; regulation of oxidative phosphorylation [GO:0002082]; response to type I interferon [GO:0034340]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653] | BRISC complex [GO:0070552]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; microtubule cytoskeleton [GO:0015630]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634] | chromatin binding [GO:0003682]; cobalt ion binding [GO:0050897]; glycine hydroxymethyltransferase activity [GO:0004372]; identical protein binding [GO:0042802]; L-allo-threonine aldolase activity [GO:0008732]; pyridoxal phosphate binding [GO:0030170]; serine binding [GO:0070905]; zinc ion binding [GO:0008270] | 42637.26985534915 | -0.11478192287345 | 0.00611768220197315 | 0.0315116248694362 |
| Q9BQE5 | Q9BQE5 | APOL2_HUMAN | Apolipoprotein L2 (Apolipoprotein L-II) (ApoL-II) | APOL2 | acute-phase response [GO:0006953]; cholesterol metabolic process [GO:0008203]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157]; maternal process involved in female pregnancy [GO:0060135] | endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; membrane [GO:0016020] | high-density lipoprotein particle binding [GO:0008035]; lipid binding [GO:0008289]; signaling receptor binding [GO:0005102] | 41639.15608304005 | 0.321711310600564 | 0.00612440061227163 | 0.0315175784460772 |
| Q9NVS9 | Q9NVS9 | PNPO_HUMAN | Pyridoxine-5'-phosphate oxidase (EC 1.4.3.5) (Pyridoxamine-phosphate oxidase) | PNPO | pyridoxal phosphate biosynthetic process [GO:0042823]; pyridoxamine metabolic process [GO:0042818]; pyridoxine biosynthetic process [GO:0008615] | cytosol [GO:0005829] | FMN binding [GO:0010181]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; pyridoxamine phosphate oxidase activity [GO:0004733] | 34618.83008979905 | 0.326843262055437 | 0.00614989923584447 | 0.0316200808260388 |
| P22234 | P22234 | PUR6_HUMAN | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)] | PAICS | 'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; GMP biosynthetic process [GO:0006177]; purine nucleobase biosynthetic process [GO:0009113] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020] | 5-amino-4-imidazole carboxylate lyase activity [GO:0043727]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; phosphoribosylaminoimidazole carboxylase activity [GO:0004638]; phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [GO:0004639] | 55546.35309634415 | 0.201740937381791 | 0.00629574966869633 | 0.0323113384264795 |
| Q4KMQ2 | Q4KMQ2 | ANO6_HUMAN | Anoctamin-6 (Small-conductance calcium-activated nonselective cation channel) (SCAN channel) (Transmembrane protein 16F) | ANO6 | activation of blood coagulation via clotting cascade [GO:0002543]; bleb assembly [GO:0032060]; blood coagulation [GO:0007596]; calcium activated phosphatidylcholine scrambling [GO:0061590]; calcium activated phosphatidylserine scrambling [GO:0061589]; calcium ion transmembrane transport [GO:0070588]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cell volume [GO:0045794]; phosphatidylserine exposure on blood platelet [GO:0097045]; plasma membrane phospholipid scrambling [GO:0017121]; pore complex assembly [GO:0046931]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone mineralization [GO:0030501]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of potassium ion export across plasma membrane [GO:1903766]; purinergic nucleotide receptor signaling pathway [GO:0035590]; sodium ion transmembrane transport [GO:0035725] | cell surface [GO:0009986]; chloride channel complex [GO:0034707]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] | calcium-activated cation channel activity [GO:0005227]; chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]; metal ion binding [GO:0046872]; phospholipid scramblase activity [GO:0017128]; protein dimerization activity [GO:0046983]; voltage-gated chloride channel activity [GO:0005247]; voltage-gated monoatomic ion channel activity [GO:0005244] | 16605.3354797864 | -0.443300172782067 | 0.00633003530169874 | 0.0324579004700679 |
| Q9Y5G2 | Q9Y5G2 | PCDGE_HUMAN | Protocadherin gamma-B2 (PCDH-gamma-B2) | PCDHGB2 | cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] | plasma membrane [GO:0005886] | calcium ion binding [GO:0005509] | 33879.9844187375 | -0.568216603737055 | 0.00637247035980355 | 0.0326459467076373 |
| Q6P996 | Q6P996 | PDXD1_HUMAN | Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) | PDXDC1 | carboxylic acid metabolic process [GO:0019752] | Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231] | cadherin binding [GO:0045296]; carboxy-lyase activity [GO:0016831]; pyridoxal phosphate binding [GO:0030170] | 21336.4484024627 | -0.134083506113025 | 0.00641509982394434 | 0.0328346482407124 |
| P68400 | P68400 | CSK21_HUMAN | Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1) | CSNK2A1 | apoptotic process [GO:0006915]; cell cycle [GO:0007049]; chaperone-mediated protein folding [GO:0061077]; DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of translation [GO:0017148]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of aggrephagy [GO:1905337]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of Wnt signaling pathway [GO:0030177]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]; regulation of chromosome separation [GO:1905818]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; symbiont-mediated disruption of host cell PML body [GO:0075342]; Wnt signaling pathway [GO:0016055] | cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; protein kinase CK2 complex [GO:0005956]; Sin3-type complex [GO:0070822] | ATP binding [GO:0005524]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | 47914.64692854135 | 0.225264143577347 | 0.00643450801901559 | 0.0329042621261212 |
| Q9H832 | Q9H832 | UBE2Z_HUMAN | Ubiquitin-conjugating enzyme E2 Z (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Z) (Uba6-specific E2 conjugating enzyme 1) (Use1) (Ubiquitin carrier protein Z) (Ubiquitin-protein ligase Z) | UBE2Z | apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] | cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | ATP binding [GO:0005524]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; molecular adaptor activity [GO:0060090]; ubiquitin conjugating enzyme activity [GO:0061631] | 33428.409867608905 | 0.27330821094421 | 0.00644598416094948 | 0.0329332247573848 |
| Q9BV20 | Q9BV20 | MTNA_HUMAN | Methylthioribose-1-phosphate isomerase (M1Pi) (MTR-1-P isomerase) (EC 5.3.1.23) (Mediator of RhoA-dependent invasion) (S-methyl-5-thioribose-1-phosphate isomerase) (Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein) | MRI1 | L-methionine salvage from methylthioadenosine [GO:0019509]; L-methionine salvage from S-adenosylmethionine [GO:0019284] | cell projection [GO:0042995]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654] | identical protein binding [GO:0042802]; S-methyl-5-thioribose-1-phosphate isomerase activity [GO:0046523] | 11903.34539114705 | -0.542612641558933 | 0.00647990179766706 | 0.0330766879149383 |
| P47813 | P47813 | IF1AX_HUMAN | Eukaryotic translation initiation factor 1A, X-chromosomal (eIF-1A X isoform) (eIF1A X isoform) (Eukaryotic translation initiation factor 4C) (eIF-4C) | EIF1AX | ribosome assembly [GO:0042255]; translational initiation [GO:0006413] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; multi-eIF complex [GO:0043614] | RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; tRNA binding [GO:0000049] | 64916.75312187765 | 0.505907811807452 | 0.00648618358233246 | 0.0330789524549916 |
| Q9GZZ1 | Q9GZZ1 | NAA50_HUMAN | N-alpha-acetyltransferase 50 (hNaa50p) (EC 2.3.1.258) (N-acetyltransferase 13) (N-acetyltransferase 5) (hNAT5) (N-acetyltransferase san homolog) (hSAN) (N-epsilon-acetyltransferase 50) (EC 2.3.1.-) (NatE catalytic subunit) | NAA50 | establishment of mitotic sister chromatid cohesion [GO:0034087]; mitotic sister chromatid cohesion [GO:0007064]; mitotic sister chromatid cohesion, centromeric [GO:0071962]; N-terminal protein amino acid acetylation [GO:0006474] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; NatA complex [GO:0031415]; nucleolus [GO:0005730]; nucleus [GO:0005634] | histone H4 acetyltransferase activity [GO:0010485]; peptide alpha-N-acetyltransferase activity [GO:0004596]; peptidyl-lysine acetyltransferase activity [GO:0052858] | 38521.01259822725 | 0.361291101319674 | 0.00660027702646057 | 0.0336305482301489 |
| Q9HC07 | Q9HC07 | TM165_HUMAN | Putative divalent cation/proton antiporter TMEM165 (Transmembrane protein 165) (Transmembrane protein PT27) (Transmembrane protein TPARL) | TMEM165 | calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; Golgi calcium ion homeostasis [GO:0032468]; Golgi calcium ion transport [GO:0032472]; intracellular calcium ion homeostasis [GO:0006874]; manganese ion transmembrane transport [GO:0071421]; manganese ion transport [GO:0006828]; protein N-linked glycosylation [GO:0006487]; regulation of lysosomal lumen pH [GO:0035751] | cis-Golgi network membrane [GO:0033106]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588] | antiporter activity [GO:0015297]; calcium ion transmembrane transporter activity [GO:0015085]; manganese ion transmembrane transporter activity [GO:0005384] | 47197.40623257745 | 0.341245351678764 | 0.00661895812294914 | 0.033695432816379 |
| P51805 | P51805 | PLXA3_HUMAN | Plexin-A3 (Plexin-4) (Semaphorin receptor SEX) | PLXNA3 | axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; branchiomotor neuron axon guidance [GO:0021785]; facial nerve structural organization [GO:0021612]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; hippocampus development [GO:0021766]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of cell adhesion [GO:0007162]; neuron projection guidance [GO:0097485]; olfactory nerve formation [GO:0021628]; positive regulation of axonogenesis [GO:0050772]; positive regulation of cytoskeleton organization [GO:0051495]; pyramidal neuron development [GO:0021860]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; trigeminal nerve structural organization [GO:0021637] | plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116] | semaphorin receptor activity [GO:0017154] | 5243.5822891363005 | -0.40846770056964 | 0.0066310650116058 | 0.0337267633355103 |
| Q8IVM0 | Q8IVM0 | CCD50_HUMAN | Coiled-coil domain-containing protein 50 (Protein Ymer) | CCDC50 | sensory perception of sound [GO:0007605] | cytoplasm [GO:0005737]; cytosol [GO:0005829] | ubiquitin protein ligase binding [GO:0031625] | 27842.08553355305 | 0.257053459765065 | 0.00671111825637281 | 0.0341033148346263 |
| Q7Z2W9 | Q7Z2W9 | RM21_HUMAN | Large ribosomal subunit protein bL21m (39S ribosomal protein L21, mitochondrial) (L21mt) (MRP-L21) | MRPL21 | mitochondrial translation [GO:0032543] | mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 5552.059643171745 | -0.315745170809648 | 0.00675882288028456 | 0.0343149555911221 |
| Q06210 | Q06210 | GFPT1_HUMAN | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 1) (Glutamine:fructose-6-phosphate amidotransferase 1) (GFAT 1) (GFAT1) (Hexosephosphate aminotransferase 1) | GFPT1 | circadian regulation of gene expression [GO:0032922]; energy reserve metabolic process [GO:0006112]; fructose 6-phosphate metabolic process [GO:0006002]; glutamine metabolic process [GO:0006541]; protein N-linked glycosylation [GO:0006487]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]; UDP-N-acetylglucosamine metabolic process [GO:0006047] | cytosol [GO:0005829]; extracellular exosome [GO:0070062] | carbohydrate derivative binding [GO:0097367]; glutamine-fructose-6-phosphate transaminase (isomerizing) activity [GO:0004360] | 64544.194699526255 | 0.151325982326179 | 0.00685615007889761 | 0.0347157697471259 |
| Q96QK1 | Q96QK1 | VPS35_HUMAN | Vacuolar protein sorting-associated protein 35 (hVPS35) (Maternal-embryonic 3) (Vesicle protein sorting 35) | VPS35 | endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886]; lysosome organization [GO:0007040]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrion to lysosome vesicle-mediated transport [GO:0099074]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of late endosome to lysosome transport [GO:1902823]; negative regulation of lysosomal protein catabolic process [GO:1905166]; negative regulation of protein homooligomerization [GO:0032463]; negative regulation of protein localization [GO:1903828]; neurotransmitter receptor transport, endosome to plasma membrane [GO:0099639]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dopamine biosynthetic process [GO:1903181]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; positive regulation of gene expression [GO:0010628]; positive regulation of locomotion involved in locomotory behavior [GO:0090326]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein localization to cell periphery [GO:1904377]; positive regulation of Wnt protein secretion [GO:0061357]; protein destabilization [GO:0031648]; protein localization to endosome [GO:0036010]; regulation of dendritic spine maintenance [GO:1902950]; regulation of macroautophagy [GO:0016241]; regulation of mitochondrion organization [GO:0010821]; regulation of postsynapse assembly [GO:0150052]; regulation of presynapse assembly [GO:1905606]; regulation of protein metabolic process [GO:0051246]; regulation of protein stability [GO:0031647]; regulation of synapse maturation [GO:0090128]; regulation of terminal button organization [GO:2000331]; retrograde transport, endosome to Golgi [GO:0042147]; transcytosis [GO:0045056]; vesicle-mediated transport in synapse [GO:0099003]; voluntary musculoskeletal movement [GO:0050882]; Wnt signaling pathway [GO:0016055] | cytosol [GO:0005829]; dopaminergic synapse [GO:0098691]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; mitochondrion-derived vesicle [GO:0099073]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; retromer complex [GO:0030904]; retromer, cargo-selective complex [GO:0030906]; tubular endosome [GO:0097422] | D1 dopamine receptor binding [GO:0031748] | 37483.58140626575 | -0.209251165698655 | 0.0068529605078093 | 0.0347157697471259 |
| Q9UPQ0 | Q9UPQ0 | LIMC1_HUMAN | LIM and calponin homology domains-containing protein 1 | LIMCH1 | actomyosin structure organization [GO:0031032]; cytoplasmic actin-based contraction involved in cell motility [GO:0060327]; negative regulation of cell migration [GO:0030336]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; regulation of focal adhesion assembly [GO:0051893] | cytoplasm [GO:0005737]; stress fiber [GO:0001725] | actin binding [GO:0003779]; metal ion binding [GO:0046872]; myosin II head/neck binding [GO:0032034] | 10813.253292951 | -0.515732843717113 | 0.00686597858878372 | 0.0347344952536148 |
| Q8N511 | Q8N511 | TM199_HUMAN | Transmembrane protein 199 | TMEM199 | cellular response to increased oxygen levels [GO:0036295]; intracellular iron ion homeostasis [GO:0006879]; lysosomal lumen acidification [GO:0007042]; lysosomal protein catabolic process [GO:1905146]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072] | COPI-coated vesicle membrane [GO:0030663]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; lysosome [GO:0005764]; vacuolar proton-transporting V-type ATPase complex [GO:0016471] | oxysterol binding [GO:0008142] | 13633.561516966849 | 0.399618328788854 | 0.00688136554220492 | 0.0347812820358012 |
| P62304 | P62304 | RUXE_HUMAN | Small nuclear ribonucleoprotein E (snRNP-E) (Sm protein E) (Sm-E) (SmE) | SNRPE | 7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241] | catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; precatalytic spliceosome [GO:0071011]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; telomerase holoenzyme complex [GO:0005697]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; U7 snRNP [GO:0005683] | RNA binding [GO:0003723] | 19305.3534945167 | -1.4927773096152 | 0.0069593490312646 | 0.035112797516603 |
| Q52LW3 | Q52LW3 | RHG29_HUMAN | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | ARHGAP29 | regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991] | GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165] | 2607.18929879811 | 1.35572558753409 | 0.00699339131909763 | 0.0352531630017858 |
| Q8N9N7 | Q8N9N7 | LRC57_HUMAN | Leucine-rich repeat-containing protein 57 | LRRC57 | extracellular exosome [GO:0070062]; membrane [GO:0016020] | 7039.791884135785 | -1.15554044737718 | 0.00704491217960307 | 0.0354813088085609 | ||
| Q9NQX7 | Q9NQX7 | ITM2C_HUMAN | Integral membrane protein 2C (Cerebral protein 14) (Transmembrane protein BRI3) [Cleaved into: CT-BRI3] | ITM2C | negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; negative regulation of neuron projection development [GO:0010977]; neuron differentiation [GO:0030182]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238] | extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] | amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524] | 9956.892049566894 | -0.539357689392799 | 0.00712499217920594 | 0.0358209455966112 |
| Q5JTV8 | Q5JTV8 | TOIP1_HUMAN | Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) | TOR1AIP1 | nuclear membrane organization [GO:0071763]; positive regulation of ATP-dependent activity [GO:0032781]; protein localization to nuclear envelope [GO:0090435]; protein localization to nucleus [GO:0034504] | nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; nucleus [GO:0005634] | ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; cytoskeletal protein binding [GO:0008092]; lamin binding [GO:0005521] | 53833.646295342245 | 0.20523308631482 | 0.00712288350782696 | 0.0358209455966112 |
| P35637 | P35637 | FUS_HUMAN | RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) | FUS | amyloid fibril formation [GO:1990000]; mRNA stabilization [GO:0048255]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; protein homooligomerization [GO:0051260]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA splicing [GO:0008380] | cytoplasm [GO:0005737]; intracellular non-membrane-bounded organelle [GO:0043232]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | chromatin binding [GO:0003682]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] | 48126.676916306504 | 0.430789581258581 | 0.00715335448119104 | 0.0359316546900961 |
| Q8IUX7 | Q8IUX7 | AEBP1_HUMAN | Adipocyte enhancer-binding protein 1 (AE-binding protein 1) (Aortic carboxypeptidase-like protein) | AEBP1 | negative regulation of transcription by RNA polymerase II [GO:0000122]; peptide metabolic process [GO:0006518]; protein processing [GO:0016485]; regulation of collagen fibril organization [GO:1904026]; regulation of DNA-templated transcription [GO:0006355] | collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634] | calmodulin binding [GO:0005516]; collagen binding [GO:0005518]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metallocarboxypeptidase activity [GO:0004181]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270] | 9952.795285243965 | 0.23771674742667 | 0.00718087888284864 | 0.0360151639802266 |
| Q8NDA8 | Q8NDA8 | MROH1_HUMAN | Maestro heat-like repeat-containing protein family member 1 (HEAT repeat-containing protein 7A) | MROH1 | cytoplasm [GO:0005737] | 4189.99742900638 | -0.954900139759898 | 0.00718269242810731 | 0.0360151639802266 | ||
| O15269 | O15269 | SPTC1_HUMAN | Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1) | SPTLC1 | ceramide biosynthetic process [GO:0046513]; positive regulation of lipophagy [GO:1904504]; regulation of fat cell apoptotic process [GO:1904649]; sphinganine biosynthetic process [GO:0046511]; sphingolipid biosynthetic process [GO:0030148]; sphingolipid metabolic process [GO:0006665]; sphingomyelin biosynthetic process [GO:0006686]; sphingosine biosynthetic process [GO:0046512] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; serine C-palmitoyltransferase complex [GO:0017059]; SPOTS complex [GO:0035339] | pyridoxal phosphate binding [GO:0030170]; serine C-palmitoyltransferase activity [GO:0004758] | 15632.904148894999 | -0.259949527235161 | 0.0072334286125299 | 0.0362374947114009 |
| P20810 | P20810 | ICAL_HUMAN | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | CAST | inhibition of cysteine-type endopeptidase activity [GO:0097340]; negative regulation of type B pancreatic cell apoptotic process [GO:2000675]; presynaptic active zone organization [GO:1990709] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] | cadherin binding [GO:0045296]; calcium-dependent cysteine-type endopeptidase inhibitor activity [GO:0010859]; endopeptidase inhibitor activity [GO:0004866]; RNA binding [GO:0003723] | 70972.82643321896 | 0.176885458970926 | 0.00729918069510247 | 0.0365345917124122 |
| Q9C037 | Q9C037 | TRIM4_HUMAN | E3 ubiquitin-protein ligase TRIM4 (EC 2.3.2.27) (RING finger protein 87) (RING-type E3 ubiquitin transferase TRIM4) (Tripartite motif-containing protein 4) | TRIM4 | innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] | identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] | 3482.600856899855 | -0.27638178036947 | 0.00732091252571495 | 0.0366110241577237 |
| O00622 | O00622 | CCN1_HUMAN | CCN family member 1 (Cellular communication network factor 1) (Cysteine-rich angiogenic inducer 61) (Insulin-like growth factor-binding protein 10) (IBP-10) (IGF-binding protein 10) (IGFBP-10) (Protein CYR61) (Protein GIG1) | CCN1 | apoptotic process involved in heart morphogenesis [GO:0003278]; atrial septum morphogenesis [GO:0060413]; atrioventricular valve morphogenesis [GO:0003181]; cell adhesion [GO:0007155]; chemotaxis [GO:0006935]; chondroblast differentiation [GO:0060591]; chorio-allantoic fusion [GO:0060710]; extracellular matrix organization [GO:0030198]; intussusceptive angiogenesis [GO:0002041]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of apoptotic process [GO:0043066]; osteoblast differentiation [GO:0001649]; positive regulation of apoptotic process [GO:0043065]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; reactive oxygen species metabolic process [GO:0072593]; regulation of ERK1 and ERK2 cascade [GO:0070372]; signal transduction [GO:0007165]; ventricular septum development [GO:0003281]; wound healing, spreading of cells [GO:0044319] | collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615] | extracellular matrix binding [GO:0050840]; growth factor binding [GO:0019838]; heparin binding [GO:0008201]; integrin binding [GO:0005178] | 35250.85447609585 | -0.207735168611403 | 0.00735391505713761 | 0.0367436355500368 |
| P41227 | P41227 | NAA10_HUMAN | N-alpha-acetyltransferase 10 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (hARD1) (NatA catalytic subunit Naa10) | NAA10 | chromosome organization [GO:0051276]; internal protein amino acid acetylation [GO:0006475]; N-terminal protein amino acid acetylation [GO:0006474]; negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric [GO:2000719]; protein acetylation [GO:0006473] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; NatA complex [GO:0031415]; nucleolus [GO:0005730]; nucleus [GO:0005634] | N-acetyltransferase activity [GO:0008080]; peptide alpha-N-acetyltransferase activity [GO:0004596]; peptide-glutamate-alpha-N-acetyltransferase activity [GO:1990190]; peptide-serine-alpha-N-acetyltransferase activity [GO:1990189] | 33270.50143848975 | 0.341207313194416 | 0.00742004041300138 | 0.0370413647401461 |
| Q9NP79 | Q9NP79 | VTA1_HUMAN | Vacuolar protein sorting-associated protein VTA1 homolog (Dopamine-responsive gene 1 protein) (DRG-1) (LYST-interacting protein 5) (LIP5) (SKD1-binding protein 1) (SBP1) | VTA1 | ESCRT III complex disassembly [GO:1904903]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; macroautophagy [GO:0016236]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; protein transport [GO:0015031] | cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; multivesicular body [GO:0005771]; nucleoplasm [GO:0005654] | 55371.4506563353 | 0.245212705486662 | 0.00746803848852994 | 0.0372481567570516 | |
| Q8TD16 | Q8TD16 | BICD2_HUMAN | Protein bicaudal D homolog 2 (Bic-D 2) | BICD2 | centrosome localization [GO:0051642]; microtubule anchoring at microtubule organizing center [GO:0072393]; microtubule-based movement [GO:0007018]; minus-end-directed organelle transport along microtubule [GO:0072385]; mRNA transport [GO:0051028]; protein localization to Golgi apparatus [GO:0034067]; protein transport [GO:0015031]; regulation of microtubule cytoskeleton organization [GO:0070507]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890] | annulate lamellae [GO:0005642]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886] | cytoskeletal anchor activity [GO:0008093]; dynactin binding [GO:0034452]; dynein complex binding [GO:0070840]; dynein light intermediate chain binding [GO:0051959]; small GTPase binding [GO:0031267] | 14730.7235563307 | 0.326696601647738 | 0.0075997431435198 | 0.0378717191303282 |
| Q8N5C1 | Q8N5C1 | CAHM5_HUMAN | Calcium homeostasis modulator protein 5 (Protein FAM26E) | CALHM5 | membrane [GO:0016020] | monoatomic cation channel activity [GO:0005261] | 8109.292623791291 | -1.68404247177636 | 0.00761524090567536 | 0.0379156019082219 | |
| Q9H4L5 | Q9H4L5 | OSBL3_HUMAN | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | OSBPL3 | bile acid biosynthetic process [GO:0006699] | cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; filopodium tip [GO:0032433]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886] | cholesterol binding [GO:0015485]; sterol transporter activity [GO:0015248] | 6946.9751937779 | -0.27653737269788 | 0.00766808313708249 | 0.0381117184690433 |
| Q9BXP2 | Q9BXP2 | S12A9_HUMAN | Solute carrier family 12 member 9 (Cation-chloride cotransporter 6) (hCCC6) (Cation-chloride cotransporter-interacting protein 1) (CCC-interacting protein 1) (hCIP1) (Potassium-chloride transporter 9) (WO3.3) | SLC12A9 | cell volume homeostasis [GO:0006884]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; potassium ion homeostasis [GO:0055075] | extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886] | chloride:monoatomic cation symporter activity [GO:0015377]; potassium:chloride symporter activity [GO:0015379] | 3214.91541019102 | -0.561731149927061 | 0.00766507059103371 | 0.0381117184690433 |
| Q9Y6A1 | Q9Y6A1 | POMT1_HUMAN | Protein O-mannosyl-transferase 1 (EC 2.4.1.109) (Dolichyl-phosphate-mannose--protein mannosyltransferase 1) | POMT1 | extracellular matrix organization [GO:0030198]; positive regulation of protein O-linked glycosylation [GO:1904100]; protein O-linked glycosylation [GO:0006493]; protein O-linked mannosylation [GO:0035269] | acrosomal vesicle [GO:0001669]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; sarcoplasmic reticulum [GO:0016529] | dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030]; metal ion binding [GO:0046872] | 3473.3674952239953 | -0.557395308710941 | 0.00770013480198306 | 0.0382374792182612 |
| Q86XZ4 | Q86XZ4 | SPAS2_HUMAN | Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr) | SPATS2 | cytoplasm [GO:0005737]; cytosol [GO:0005829] | RNA binding [GO:0003723] | 15079.0080262644 | 0.158450860165558 | 0.00775481457171835 | 0.0384752884092436 | |
| O14907 | O14907 | TX1B3_HUMAN | Tax1-binding protein 3 (Glutaminase-interacting protein 3) (Tax interaction protein 1) (TIP-1) (Tax-interacting protein 1) | TAX1BP3 | activation of GTPase activity [GO:0090630]; cell-cell adhesion [GO:0098609]; chemical synaptic transmission [GO:0007268]; embryo development [GO:0009790]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of Wnt signaling pathway [GO:0030178]; receptor clustering [GO:0043113]; receptor localization to synapse [GO:0097120]; Rho protein signal transduction [GO:0007266]; Wnt signaling pathway [GO:0016055] | actin cytoskeleton [GO:0015629]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; postsynaptic density membrane [GO:0098839] | beta-catenin binding [GO:0008013] | 22132.28877600525 | -1.04052070570201 | 0.00783149863410464 | 0.0388217596332781 |
| P52565 | P52565 | GDIR1_HUMAN | Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha) | ARHGDIA | negative regulation of apoptotic process [GO:0043066]; regulation of protein localization [GO:0032880]; regulation of Rho protein signal transduction [GO:0035023]; regulation of synaptic vesicle cycle [GO:0098693]; Rho protein signal transduction [GO:0007266]; semaphorin-plexin signaling pathway [GO:0071526] | cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; immunological synapse [GO:0001772]; membrane [GO:0016020]; nucleus [GO:0005634]; Schaffer collateral - CA1 synapse [GO:0098685] | GTPase activator activity [GO:0005096]; Rho GDP-dissociation inhibitor activity [GO:0005094] | 310372.281599852 | 0.337296512036216 | 0.00785562196430075 | 0.038873322314173 |
| Q8WUI4 | Q8WUI4 | HDAC7_HUMAN | Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-) | HDAC7 | cell-cell junction assembly [GO:0007043]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; protein deacetylation [GO:0006476]; protein sumoylation [GO:0016925]; regulation of mRNA processing [GO:0050684]; vasculogenesis [GO:0001570] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | 14-3-3 protein binding [GO:0071889]; chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase activity [GO:0004407]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; protein kinase C binding [GO:0005080]; protein lysine deacetylase activity [GO:0033558]; SUMO transferase activity [GO:0019789]; transcription corepressor activity [GO:0003714] | 14737.64302912745 | -0.310647069653371 | 0.00787683127962906 | 0.0389442635518135 |
| Q96N66 | Q96N66 | MBOA7_HUMAN | Lysophospholipid acyltransferase 7 (LPLAT 7) (EC 2.3.1.-) (1-acylglycerophosphatidylinositol O-acyltransferase) (Bladder and breast carcinoma-overexpressed gene 1 protein) (Leukocyte receptor cluster member 4) (Lysophosphatidylinositol acyltransferase) (LPIAT) (Lyso-PI acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 7) (O-acyltransferase domain-containing protein 7) (h-mboa-7) | MBOAT7 | layer formation in cerebral cortex [GO:0021819]; lipid modification [GO:0030258]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylinositol acyl-chain remodeling [GO:0036149]; phosphatidylinositol biosynthetic process [GO:0006661]; regulation of triglyceride metabolic process [GO:0090207]; ventricular system development [GO:0021591] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233] | 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; lysophospholipid acyltransferase activity [GO:0071617]; O-acyltransferase activity [GO:0008374] | 15904.802655133099 | -0.671908826645381 | 0.00789209673703938 | 0.0389857193653576 |
| P08582 | P08582 | TRFM_HUMAN | Melanotransferrin (Melanoma-associated antigen p97) (CD antigen CD228) | MELTF | iron ion transport [GO:0006826]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of plasminogen activation [GO:0010756] | cell surface [GO:0009986]; early endosome [GO:0005769]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; side of membrane [GO:0098552] | iron ion binding [GO:0005506] | 5900.790190900345 | 0.561066021987808 | 0.00793359704106136 | 0.0391565860929039 |
| Q7Z434 | Q7Z434 | MAVS_HUMAN | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) | MAVS | activation of innate immune response [GO:0002218]; antiviral innate immune response [GO:0140374]; cellular response to exogenous dsRNA [GO:0071360]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of viral genome replication [GO:0045071]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of IP-10 production [GO:0071660]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein localization to mitochondrion [GO:0070585]; regulation of peroxisome organization [GO:1900063]; signal transduction [GO:0007165]; type I interferon-mediated signaling pathway [GO:0060337] | mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; ubiquitin ligase complex [GO:0000151] | CARD domain binding [GO:0050700]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; molecular condensate scaffold activity [GO:0140693]; protein kinase binding [GO:0019901]; RIG-I binding [GO:0039552]; signaling adaptor activity [GO:0035591] | 27244.416334981448 | -0.0854316886490357 | 0.00795086582183504 | 0.0391811196216521 |
| Q5T5C0 | Q5T5C0 | STXB5_HUMAN | Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1) | STXBP5 | exocytosis [GO:0006887]; positive regulation of exocytosis [GO:0045921]; protein transport [GO:0015031]; regulation of exocytosis [GO:0017157]; regulation of protein secretion [GO:0050708]; regulation of synaptic vesicle exocytosis [GO:2000300]; regulation of synaptic vesicle priming [GO:0010807] | acetylcholine-gated channel complex [GO:0005892]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of neuronal dense core vesicle membrane [GO:0098674]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021] | GTPase activator activity [GO:0005096]; myosin II binding [GO:0045159]; syntaxin binding [GO:0019905]; syntaxin-1 binding [GO:0017075] | 15669.673144457502 | -0.234004672954775 | 0.00797367253598187 | 0.0392518058982392 |
| Q9BV57 | Q9BV57 | MTND_HUMAN | Acireductone dioxygenase (Acireductone dioxygenase (Fe(2+)-requiring)) (ARD') (Fe-ARD) (EC 1.13.11.54) (Acireductone dioxygenase (Ni(2+)-requiring)) (ARD) (Ni-ARD) (EC 1.13.11.53) (Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1) (MTCBP-1) (Submergence-induced protein-like factor) (Sip-L) | ADI1 | L-methionine salvage from methylthioadenosine [GO:0019509]; methionine metabolic process [GO:0006555] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | acireductone dioxygenase (Ni2+-requiring) activity [GO:0010308]; acireductone dioxygenase [iron(II)-requiring] activity [GO:0010309]; iron ion binding [GO:0005506]; nickel cation binding [GO:0016151]; oxidoreductase activity [GO:0016491] | 27109.974493326 | 0.549437447626945 | 0.00799999423396557 | 0.0393130679355151 |
| P50135 | P50135 | HNMT_HUMAN | Histamine N-methyltransferase (HMT) (EC 2.1.1.8) | HNMT | histamine catabolic process [GO:0001695]; histamine metabolic process [GO:0001692]; histidine catabolic process [GO:0006548]; methylation [GO:0032259]; respiratory gaseous exchange by respiratory system [GO:0007585] | centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654] | histamine N-methyltransferase activity [GO:0046539] | 10634.37143276495 | 0.66312063799127 | 0.00811569034823775 | 0.0398431551363693 |
| Q8NHP6 | Q8NHP6 | MSPD2_HUMAN | Motile sperm domain-containing protein 2 | MOSPD2 | chemotaxis [GO:0006935]; lipid droplet formation [GO:0140042]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of neutrophil chemotaxis [GO:0090023]; protein homooligomerization [GO:0051260] | endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-endosome membrane contact site [GO:0140284]; membrane [GO:0016020]; organelle membrane contact site [GO:0044232]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] | FFAT motif binding [GO:0033149] | 14196.486157188749 | -0.184217096828984 | 0.00812192802373925 | 0.0398431551363693 |
| Q9NPJ3 | Q9NPJ3 | ACO13_HUMAN | Acyl-coenzyme A thioesterase 13 (Acyl-CoA thioesterase 13) (EC 3.1.2.-) (Hotdog-fold thioesterase superfamily member 2) (Palmitoyl-CoA hydrolase) (EC 3.1.2.2) (Thioesterase superfamily member 2) (THEM2) [Cleaved into: Acyl-coenzyme A thioesterase 13, N-terminally processed] | ACOT13 | lipid metabolic process [GO:0006629]; negative regulation of cold-induced thermogenesis [GO:0120163]; protein homotetramerization [GO:0051289] | cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634]; spindle [GO:0005819] | fatty acyl-CoA hydrolase activity [GO:0047617]; metal ion binding [GO:0046872] | 6395.068147808165 | -1.17926939970256 | 0.00822232722922514 | 0.0402659516687896 |
| Q9NUP9 | Q9NUP9 | LIN7C_HUMAN | Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3) | LIN7C | exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; morphogenesis of an epithelial sheet [GO:0002011]; neurotransmitter secretion [GO:0007269]; protein localization to basolateral plasma membrane [GO:1903361]; protein transport [GO:0015031] | basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; MPP7-DLG1-LIN7 complex [GO:0097025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; synapse [GO:0045202] | cytoskeletal protein binding [GO:0008092]; L27 domain binding [GO:0097016]; protein domain specific binding [GO:0019904] | 27897.1777221518 | 0.310824367568171 | 0.00822955222827936 | 0.0402665310236881 |
| P57740 | P57740 | NU107_HUMAN | Nuclear pore complex protein Nup107 (107 kDa nucleoporin) (Nucleoporin Nup107) | NUP107 | female gonad development [GO:0008585]; mRNA export from nucleus [GO:0006406]; nephron development [GO:0072006]; nuclear pore complex assembly [GO:0051292]; nucleocytoplasmic transport [GO:0006913]; post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000973]; protein import into nucleus [GO:0006606] | cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080] | structural constituent of nuclear pore [GO:0017056] | 8702.128149643135 | -0.299597959822716 | 0.00824840815718061 | 0.0403239694724636 |
| P67812 | P67812 | SC11A_HUMAN | Signal peptidase complex catalytic subunit SEC11A (EC 3.4.21.89) (Endopeptidase SP18) (Microsomal signal peptidase 18 kDa subunit) (SPase 18 kDa subunit) (SEC11 homolog A) (SEC11-like protein 1) (SPC18) | SEC11A | response to virus [GO:0009615]; signal peptide processing [GO:0006465] | endoplasmic reticulum membrane [GO:0005789]; signal peptidase complex [GO:0005787] | peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252] | 30719.134083922698 | -0.4238333090366 | 0.00826712128950409 | 0.0403806114020088 |
| Q9UBP9 | Q9UBP9 | GULP1_HUMAN | PTB domain-containing engulfment adapter protein 1 (Cell death protein 6 homolog) (PTB domain adapter protein CED-6) (Protein GULP) | GULP1 | apoptotic process [GO:0006915]; lipid transport [GO:0006869]; phagocytosis, engulfment [GO:0006911] | cytoplasm [GO:0005737] | 15472.723190139699 | -0.765539323670605 | 0.00827753154177388 | 0.0403966354140317 | |
| P07814 | P07814 | SYEP_HUMAN | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | EPRS1 | cellular response to insulin stimulus [GO:0032869]; cellular response to type II interferon [GO:0071346]; glutamyl-tRNA aminoacylation [GO:0006424]; negative regulation of translation [GO:0017148]; prolyl-tRNA aminoacylation [GO:0006433]; regulation of long-chain fatty acid import into cell [GO:0140212]; tRNA aminoacylation for protein translation [GO:0006418] | aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GAIT complex [GO:0097452]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904] | ATP binding [GO:0005524]; glutamate-tRNA ligase activity [GO:0004818]; GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; proline-tRNA ligase activity [GO:0004827]; protein homodimerization activity [GO:0042803]; RNA stem-loop binding [GO:0035613]; zinc ion binding [GO:0008270] | 56247.19160403575 | -0.210215852795762 | 0.00837060931091467 | 0.0407806297125043 |
| O75663 | O75663 | TIPRL_HUMAN | TIP41-like protein (Putative MAPK-activating protein PM10) (Type 2A-interacting protein) (TIP) | TIPRL | DNA damage checkpoint signaling [GO:0000077]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; TOR signaling [GO:0031929] | cytosol [GO:0005829] | 25773.125569665448 | 0.164822800617824 | 0.00838966606489066 | 0.040838357322741 | |
| Q10472 | Q10472 | GALT1_HUMAN | Polypeptide N-acetylgalactosaminyltransferase 1 (EC 2.4.1.41) (Polypeptide GalNAc transferase 1) (GalNAc-T1) (pp-GaNTase 1) (Protein-UDP acetylgalactosaminyltransferase 1) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 1 soluble form] | GALNT1 | O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; protein O-linked glycosylation via threonine [GO:0018243]; viral protein processing [GO:0019082] | endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular region [GO:0005576]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471] | carbohydrate binding [GO:0030246]; manganese ion binding [GO:0030145]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] | 10244.7532658868 | -0.186924805981755 | 0.00839701376320282 | 0.0408390386114225 |
| P36507 | P36507 | MP2K2_HUMAN | Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2) | MAP2K2 | epithelial cell proliferation involved in lung morphogenesis [GO:0060502]; ERBB2-ERBB3 signaling pathway [GO:0038133]; ERK1 and ERK2 cascade [GO:0070371]; face development [GO:0060324]; heart development [GO:0007507]; insulin-like growth factor receptor signaling pathway [GO:0048009]; MAPK cascade [GO:0000165]; myelination [GO:0042552]; peptidyl-serine autophosphorylation [GO:0036289]; positive regulation of axonogenesis [GO:0050772]; positive regulation of cell motility [GO:2000147]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; regulation of axon regeneration [GO:0048679]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of stress-activated MAPK cascade [GO:0032872]; Schwann cell development [GO:0014044]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trachea formation [GO:0060440] | cell-cell junction [GO:0005911]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal membrane [GO:0005778] | ATP binding [GO:0005524]; MAP kinase kinase activity [GO:0004708]; MAP-kinase scaffold activity [GO:0005078]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; scaffold protein binding [GO:0097110] | 22488.3905881742 | 0.305087249225414 | 0.00841519274381374 | 0.0408923517036438 |
| Q15858 | Q15858 | SCN9A_HUMAN | Sodium channel protein type 9 subunit alpha (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1) (PN1) (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) | SCN9A | behavioral response to pain [GO:0048266]; cardiac muscle cell action potential involved in contraction [GO:0086002]; circadian rhythm [GO:0007623]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; inflammatory response [GO:0006954]; membrane depolarization during action potential [GO:0086010]; neuronal action potential [GO:0019228]; post-embryonic development [GO:0009791]; response to toxic substance [GO:0009636]; sensory perception of pain [GO:0019233]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814] | axon [GO:0030424]; plasma membrane [GO:0005886]; voltage-gated sodium channel complex [GO:0001518] | voltage-gated sodium channel activity [GO:0005248] | 16173.1888893841 | -0.519773034757806 | 0.0084384493410985 | 0.0409702261925142 |
| P62316 | P62316 | SMD2_HUMAN | Small nuclear ribonucleoprotein Sm D2 (Sm-D2) (snRNP core protein D2) | SNRPD2 | 7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241] | catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; precatalytic spliceosome [GO:0071011]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682] | RNA binding [GO:0003723] | 236157.27929593698 | 0.262587358961439 | 0.00867084149750058 | 0.0420265080623082 |
| Q9Y3B7 | Q9Y3B7 | RM11_HUMAN | Large ribosomal subunit protein uL11m (39S ribosomal protein L11, mitochondrial) (L11mt) (MRP-L11) | MRPL11 | mitochondrial translation [GO:0032543]; translation [GO:0006412] | mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739] | large ribosomal subunit rRNA binding [GO:0070180]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 22288.73620163605 | -0.931915272632719 | 0.00881352623684611 | 0.0426815723572393 |
| Q9NUM4 | Q9NUM4 | T106B_HUMAN | Transmembrane protein 106B | TMEM106B | dendrite morphogenesis [GO:0048813]; lysosomal lumen acidification [GO:0007042]; lysosomal protein catabolic process [GO:1905146]; lysosomal transport [GO:0007041]; lysosome localization [GO:0032418]; lysosome organization [GO:0007040]; neuron cellular homeostasis [GO:0070050]; positive regulation of dendrite development [GO:1900006]; regulation of lysosome organization [GO:1905671] | endosome [GO:0005768]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886] | ATPase binding [GO:0051117] | 24410.59941142045 | 0.448095612062327 | 0.00882842876714311 | 0.0427172309091656 |
| P08571 | P08571 | CD14_HUMAN | Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein) (CD antigen CD14) [Cleaved into: Monocyte differentiation antigen CD14, urinary form; Monocyte differentiation antigen CD14, membrane-bound form] | CD14 | apoptotic process [GO:0006915]; cell surface pattern recognition receptor signaling pathway [GO:0002752]; cell surface receptor signaling pathway [GO:0007166]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to molecule of bacterial origin [GO:0071219]; cellular response to triacyl bacterial lipopeptide [GO:0071727]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; phagocytosis [GO:0006909]; positive regulation of cytokine production [GO:0001819]; positive regulation of endocytosis [GO:0045807]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type II interferon production [GO:0032729]; receptor-mediated endocytosis [GO:0006898]; response to electrical stimulus [GO:0051602]; response to ethanol [GO:0045471]; response to magnesium ion [GO:0032026]; response to tumor necrosis factor [GO:0034612]; toll-like receptor 4 signaling pathway [GO:0034142] | endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; lipopolysaccharide receptor complex [GO:0046696]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] | lipopolysaccharide binding [GO:0001530]; lipopolysaccharide immune receptor activity [GO:0001875]; lipoteichoic acid binding [GO:0070891]; opsonin receptor activity [GO:0001847]; peptidoglycan immune receptor activity [GO:0016019] | 6095.2336821218705 | -0.378234546443217 | 0.00893265510981328 | 0.0431846619899335 |
| P62495 | P62495 | ERF1_HUMAN | Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1) | ETF1 | cytoplasmic translational termination [GO:0002184]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; protein methylation [GO:0006479]; regulation of translational termination [GO:0006449]; translational termination [GO:0006415] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; translation release factor complex [GO:0018444] | aminoacyl-tRNA hydrolase activity [GO:0004045]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825]; translation release factor activity [GO:0003747]; translation release factor activity, codon specific [GO:0016149]; translation termination factor activity [GO:0008079] | 48823.379289194345 | 0.227818287686634 | 0.00897574320496951 | 0.0433559769815492 |
| O43194 | O43194 | GPR39_HUMAN | G-protein coupled receptor 39 | GPR39 | G protein-coupled receptor signaling pathway [GO:0007186] | plasma membrane [GO:0005886] | G protein-coupled receptor activity [GO:0004930]; metal ion binding [GO:0046872] | 3930.4917371922847 | 0.961065279302556 | 0.00900487277990891 | 0.043422646102948 |
| P78324 | P78324 | SHPS1_HUMAN | Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a) | SIRPA | cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-12 [GO:0071349]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to type II interferon [GO:0071346]; monocyte extravasation [GO:0035696]; negative regulation of chemokine (C-C motif) ligand 5 production [GO:0071650]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of I-kappaB phosphorylation [GO:1903720]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of JNK cascade [GO:0046329]; negative regulation of macrophage inflammatory protein 1 alpha production [GO:0071641]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of phagocytosis [GO:0050765]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of phagocytosis [GO:0050766]; positive regulation of T cell activation [GO:0050870]; regulation of gene expression [GO:0010468]; regulation of interleukin-1 beta production [GO:0032651]; regulation of interleukin-6 production [GO:0032675]; regulation of nitric oxide biosynthetic process [GO:0045428]; regulation of tumor necrosis factor production [GO:0032680]; regulation of type II interferon production [GO:0032649] | cell surface [GO:0009986]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821] | cell-cell adhesion mediator activity [GO:0098632]; GTPase regulator activity [GO:0030695]; protein antigen binding [GO:1990405]; protein binding involved in heterotypic cell-cell adhesion [GO:0086080]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase binding [GO:1990782]; SH3 domain binding [GO:0017124] | 16839.374027859747 | 0.407380670908479 | 0.00900337472853048 | 0.043422646102948 |
| P50402 | P50402 | EMD_HUMAN | Emerin | EMD | cellular response to growth factor stimulus [GO:0071363]; muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of fibroblast proliferation [GO:0048147]; nuclear membrane organization [GO:0071763]; positive regulation of protein export from nucleus [GO:0046827]; regulation of canonical Wnt signaling pathway [GO:0060828]; skeletal muscle cell differentiation [GO:0035914] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; microtubule [GO:0005874]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; nucleoplasm [GO:0005654]; spindle [GO:0005819]; TMEM240-body [GO:0160045] | actin binding [GO:0003779]; beta-tubulin binding [GO:0048487]; cadherin binding [GO:0045296] | 130628.017278619 | 0.275170777501369 | 0.00906670690473945 | 0.0436836405801477 |
| Q7Z6M1 | Q7Z6M1 | RABEK_HUMAN | Rab9 effector protein with kelch motifs (40 kDa Rab9 effector protein) (p40) | RABEPK | receptor-mediated endocytosis [GO:0006898]; vesicle docking involved in exocytosis [GO:0006904] | cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133] | 9493.120196076194 | -0.511641633523771 | 0.00911251853405951 | 0.0438670603347334 | |
| Q96EP5 | Q96EP5 | DAZP1_HUMAN | DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1) | DAZAP1 | cell differentiation [GO:0030154]; central nervous system development [GO:0007417]; fibroblast proliferation [GO:0048144]; maternal placenta development [GO:0001893]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of translation [GO:0006417]; spermatogenesis [GO:0007283] | cytosol [GO:0005829]; male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904] | mRNA 3'-UTR binding [GO:0003730]; poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613] | 33979.530767408156 | 0.28424855691135 | 0.00913750703528611 | 0.0438928037925518 |
| P06454 | P06454 | PTMA_HUMAN | Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1] | PTMA | DNA-templated transcription [GO:0006351]; negative regulation of apoptotic process [GO:0043066]; positive regulation of transcription by RNA polymerase II [GO:0045944] | cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | DNA-binding transcription factor binding [GO:0140297]; histone binding [GO:0042393]; ion binding [GO:0043167] | 53593.660582874945 | 1.51446098506564 | 0.00914110633166452 | 0.0438928037925518 |
| Q9Y3F4 | Q9Y3F4 | STRAP_HUMAN | Serine-threonine kinase receptor-associated protein (MAP activator with WD repeats) (UNR-interacting protein) (WD-40 repeat protein PT-WD) | STRAP | alternative mRNA splicing, via spliceosome [GO:0000380]; maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neuron differentiation [GO:0030182]; spliceosomal snRNP assembly [GO:0000387] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719] | mRNA binding [GO:0003729]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102]; U2 snRNP binding [GO:1990447] | 112128.23275433 | 0.0687052061623374 | 0.00913861921152213 | 0.0438928037925518 |
| Q9UKY7 | Q9UKY7 | CDV3_HUMAN | Protein CDV3 homolog | CDV3 | cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] | 58654.225249646595 | 0.460459355214772 | 0.00923390940122351 | 0.0443008727073094 | ||
| Q9NNX1 | Q9NNX1 | TUFT1_HUMAN | Tuftelin | TUFT1 | bone mineralization [GO:0030282]; intracellular signal transduction [GO:0035556]; odontogenesis [GO:0042476] | cytoplasm [GO:0005737]; extracellular region [GO:0005576] | structural constituent of skin epidermis [GO:0030280]; structural constituent of tooth enamel [GO:0030345] | 4065.22262896148 | -1.47236294643289 | 0.00929453679547246 | 0.0445540147911565 |
| Q9BY50 | Q9BY50 | SC11C_HUMAN | Signal peptidase complex catalytic subunit SEC11C (EC 3.4.21.89) (Microsomal signal peptidase 21 kDa subunit) (SPase 21 kDa subunit) (SEC11 homolog C) (SEC11-like protein 3) (SPC21) | SEC11C | signal peptide processing [GO:0006465] | endoplasmic reticulum membrane [GO:0005789]; signal peptidase complex [GO:0005787] | peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252] | 9502.17708914143 | 0.863756290460503 | 0.00939637882005635 | 0.0450041271297035 |
| P60903 | P60903 | S10AA_HUMAN | Protein S100-A10 (Calpactin I light chain) (Calpactin-1 light chain) (Cellular ligand of annexin II) (S100 calcium-binding protein A10) (p10 protein) (p11) | S100A10 | membrane raft assembly [GO:0001765]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of exocytosis [GO:0045921]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of GTPase activity [GO:0043547]; positive regulation of plasma membrane repair [GO:1905686]; positive regulation of plasminogen activation [GO:0010756]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; regulation of neurogenesis [GO:0050767]; vesicle budding from membrane [GO:0006900] | AnxA2-p11 complex [GO:1990665]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nuclear matrix [GO:0016363]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; RNA polymerase II transcription regulator complex [GO:0090575] | calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803]; transmembrane transporter binding [GO:0044325] | 293655.226936015 | 0.360776992420495 | 0.00950332349732068 | 0.045401206522613 |
| P01893 | P01893 | HLAH_HUMAN | Putative HLA class I histocompatibility antigen, alpha chain H (HLA-12.4) (HLA-AR) (MHC class I antigen H) | HLA-H | antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916] | azurophil granule membrane [GO:0035577]; cell surface [GO:0009986]; early endosome membrane [GO:0031901]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] | beta-2-microglobulin binding [GO:0030881]; peptide antigen binding [GO:0042605]; signaling receptor binding [GO:0005102] | 11065.746052781142 | 0.904331390872495 | 0.00971459815730777 | 0.0462934509329738 |
| Q9P253 | Q9P253 | VPS18_HUMAN | Vacuolar protein sorting-associated protein 18 homolog (hVPS18) | VPS18 | autophagy [GO:0006914]; endosomal vesicle fusion [GO:0034058]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; lysosome organization [GO:0007040]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; organelle fusion [GO:0048284]; protein ubiquitination [GO:0016567]; regulation of SNARE complex assembly [GO:0035542]; regulation of synaptic vesicle exocytosis [GO:2000300]; symbiont entry into host cell [GO:0046718]; vesicle docking involved in exocytosis [GO:0006904] | actin filament [GO:0005884]; AP-3 adaptor complex [GO:0030123]; autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; presynapse [GO:0098793] | actin binding [GO:0003779]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674]; syntaxin binding [GO:0019905]; ubiquitin protein ligase activity [GO:0061630] | 7624.909119074626 | -0.328961830913123 | 0.009737341962977 | 0.0463628399682585 |
| P62280 | P62280 | RS11_HUMAN | Small ribosomal subunit protein uS17 (40S ribosomal protein S11) | RPS11 | cytoplasmic translation [GO:0002181]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]; synapse [GO:0045202] | RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] | 144232.6656621235 | 0.193921200065022 | 0.00977500543321269 | 0.0465030904992301 |
| Q9NQ92 | Q9NQ92 | COPRS_HUMAN | Coordinator of PRMT5 and differentiation stimulator (Cooperator of PRMT5) (Protein TTP1) | COPRS | chromatin remodeling [GO:0006338]; muscle organ development [GO:0007517] | cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | histone binding [GO:0042393] | 16244.9599258798 | 0.787603487214415 | 0.0098252853990605 | 0.04670307640191 |
| O14613 | O14613 | BORG1_HUMAN | Cdc42 effector protein 2 (Binder of Rho GTPases 1) | CDC42EP2 | actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; cellular response to type II interferon [GO:0071346]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of pseudopodium assembly [GO:0031274]; regulation of cell shape [GO:0008360]; Rho protein signal transduction [GO:0007266] | cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886] | GTPase activator activity [GO:0005096]; opioid peptide activity [GO:0001515]; small GTPase binding [GO:0031267] | 16383.007808571601 | 0.411953829966271 | 0.0098578392902331 | 0.0468185393281314 |
| Q9HA77 | Q9HA77 | SYCM_HUMAN | Probable cysteine--tRNA ligase, mitochondrial (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS) | CARS2 | cysteinyl-tRNA aminoacylation [GO:0006423] | cytoplasm [GO:0005737]; mitochondrion [GO:0005739] | ATP binding [GO:0005524]; cysteine-tRNA ligase activity [GO:0004817]; metal ion binding [GO:0046872] | 8181.5612477490595 | 0.291228405493462 | 0.009927995648714 | 0.0470728228833586 |
| Q9H6B4 | Q9H6B4 | CLMP_HUMAN | CXADR-like membrane protein (Adipocyte adhesion molecule) (Coxsackie- and adenovirus receptor-like membrane protein) (CAR-like membrane protein) | CLMP | digestive tract development [GO:0048565] | bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; cytoplasmic microtubule [GO:0005881]; plasma membrane [GO:0005886] | 16998.031600292 | 0.551540223007713 | 0.0099776849369615 | 0.0472688652615584 | |
| Q9Y5V3 | Q9Y5V3 | MAGD1_HUMAN | Melanoma-associated antigen D1 (MAGE tumor antigen CCF) (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) | MAGED1 | circadian regulation of gene expression [GO:0032922]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; protein localization to nucleus [GO:0034504]; regulation of apoptotic process [GO:0042981]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355] | chromatin [GO:0000785]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] | identical protein binding [GO:0042802]; transcription coactivator activity [GO:0003713] | 10926.614751897101 | 0.266064729659771 | 0.00999560076964694 | 0.0473141804183956 |
| P15151 | P15151 | PVR_HUMAN | Poliovirus receptor (Nectin-like protein 5) (NECL-5) (CD antigen CD155) | PVR | acrosome assembly [GO:0001675]; coreceptor-mediated virion attachment to host cell [GO:0046814]; cytoskeleton organization [GO:0007010]; establishment of mitochondrion localization [GO:0051654]; fusion of virus membrane with host plasma membrane [GO:0019064]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; positive regulation of immunoglobulin mediated immune response [GO:0002891]; positive regulation of mast cell activation [GO:0033005]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002860]; positive regulation of T cell receptor signaling pathway [GO:0050862]; regulation of viral entry into host cell [GO:0046596]; susceptibility to natural killer cell mediated cytotoxicity [GO:0042271]; susceptibility to T cell mediated cytotoxicity [GO:0060370] | adherens junction [GO:0005912]; apical junction complex [GO:0043296]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886] | cell adhesion molecule binding [GO:0050839]; signaling receptor activity [GO:0038023]; virus receptor activity [GO:0001618] | 33716.19748873766 | 0.568163819957365 | 0.0100431179937299 | 0.047467431256257 |
| Q13642 | Q13642 | FHL1_HUMAN | Four and a half LIM domains protein 1 (FHL-1) (Skeletal muscle LIM-protein 1) (SLIM) (SLIM-1) | FHL1 | animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; muscle organ development [GO:0007517]; negative regulation of cell growth [GO:0030308]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; positive regulation of potassium ion transport [GO:0043268]; regulation of membrane depolarization [GO:0003254]; regulation of potassium ion transmembrane transporter activity [GO:1901016] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | metal ion binding [GO:0046872]; transmembrane transporter binding [GO:0044325] | 38194.54114084935 | -0.385856617609837 | 0.0102773986273526 | 0.0484860454809158 |
| P67809 | P67809 | YBOX1_HUMAN | Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor) | YBX1 | cellular response to interleukin-7 [GO:0098761]; CRD-mediated mRNA stabilization [GO:0070934]; embryonic morphogenesis [GO:0048598]; epidermis development [GO:0008544]; in utero embryonic development [GO:0001701]; miRNA transport [GO:1990428]; mRNA processing [GO:0006397]; mRNA stabilization [GO:0048255]; negative regulation of cellular senescence [GO:2000773]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; negative regulation of striated muscle cell differentiation [GO:0051154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; positive regulation of cell division [GO:0051781]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to cytoplasmic stress granule [GO:1903608]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; RNA splicing [GO:0008380]; RNA transport [GO:0050658]; tRNA transport [GO:0051031] | CRD-mediated mRNA stability complex [GO:0070937]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; histone pre-mRNA 3'end processing complex [GO:0071204]; intracellular membrane-bounded organelle [GO:0043231]; messenger ribonucleoprotein complex [GO:1990124]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202]; U12-type spliceosomal complex [GO:0005689] | C5-methylcytidine-containing RNA reader activity [GO:0062153]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; GTPase binding [GO:0051020]; miRNA binding [GO:0035198]; mRNA binding [GO:0003729]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; sequence-specific double-stranded DNA binding [GO:1990837]; single-stranded DNA binding [GO:0003697] | 176046.7351054535 | 0.406485281872025 | 0.0103032564850985 | 0.0485675967092913 |
| Q7Z2W4 | Q7Z2W4 | ZCCHV_HUMAN | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | ZC3HAV1 | defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of RIG-I signaling pathway [GO:1900246]; positive regulation of type I interferon production [GO:0032481]; response to virus [GO:0009615] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] | cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] | 17852.278319067053 | -0.230581660720204 | 0.0103121643139824 | 0.0485691795536363 |
| Q9H4A6 | Q9H4A6 | GOLP3_HUMAN | Golgi phosphoprotein 3 (Coat protein GPP34) (Mitochondrial DNA absence factor) (MIDAS) | GOLPH3 | asymmetric Golgi ribbon formation [GO:0090164]; cell adhesion molecule production [GO:0060352]; cell migration [GO:0016477]; cellular response to rapamycin [GO:0072752]; gene expression [GO:0010467]; glycoprotein biosynthetic process [GO:0009101]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi vesicle budding [GO:0048194]; lamellipodium assembly [GO:0030032]; leukocyte tethering or rolling [GO:0050901]; negative regulation of apoptotic process [GO:0043066]; positive regulation of protein secretion [GO:0050714]; positive regulation of TOR signaling [GO:0032008]; protein retention in Golgi apparatus [GO:0045053]; protein secretion [GO:0009306]; regulation of mitochondrion organization [GO:0010821]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890] | cytosol [GO:0005829]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] | enzyme binding [GO:0019899]; phosphatidylinositol-4-phosphate binding [GO:0070273] | 16031.022638338101 | 0.21340480586709 | 0.0103724689239434 | 0.0488051804924185 |
| Q9BZM5 | Q9BZM5 | ULBP2_HUMAN | UL16-binding protein 2 (ALCAN-alpha) (NKG2D ligand 2) (N2DL-2) (NKG2DL2) (Retinoic acid early transcript 1H) | ULBP2 | antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; positive regulation of T cell mediated cytotoxicity [GO:0001916] | cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] | natural killer cell lectin-like receptor binding [GO:0046703] | 14091.1497173567 | 0.939396881751527 | 0.0103794992046178 | 0.0488051804924185 |
| Q9BQB6 | Q9BQB6 | VKOR1_HUMAN | Vitamin K epoxide reductase complex subunit 1 (EC 1.17.4.4) (Vitamin K1 2,3-epoxide reductase subunit 1) | VKORC1 | blood coagulation [GO:0007596]; bone development [GO:0060348]; peptidyl-glutamic acid carboxylation [GO:0017187]; positive regulation of coagulation [GO:0050820]; regulation of blood coagulation [GO:0030193]; response to organic cyclic compound [GO:0014070]; response to organonitrogen compound [GO:0010243]; vitamin K metabolic process [GO:0042373]; xenobiotic metabolic process [GO:0006805] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] | quinone binding [GO:0048038]; vitamin-K-epoxide reductase (warfarin-insensitive) activity [GO:0047058]; vitamin-K-epoxide reductase (warfarin-sensitive) activity [GO:0047057] | 16534.58123596805 | -1.04212849157815 | 0.0103936509171669 | 0.0488311990851309 |
| Q9Y243 | Q9Y243 | AKT3_HUMAN | RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2) | AKT3 | brain morphogenesis [GO:0048854]; homeostasis of number of cells within a tissue [GO:0048873]; intracellular signal transduction [GO:0035556]; mitochondrial genome maintenance [GO:0000002]; negative regulation of cellular senescence [GO:2000773]; positive regulation of angiogenesis [GO:0045766]; positive regulation of artery morphogenesis [GO:1905653]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell size [GO:0045793]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of TOR signaling [GO:0032008]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165] | cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] | ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | 5704.8392567286355 | -0.651383388709064 | 0.0104488003048841 | 0.049009025271087 |
| O15118 | O15118 | NPC1_HUMAN | NPC intracellular cholesterol transporter 1 (Niemann-Pick C1 protein) | NPC1 | adult walking behavior [GO:0007628]; autophagy [GO:0006914]; bile acid metabolic process [GO:0008206]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to steroid hormone stimulus [GO:0071383]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol storage [GO:0010878]; cholesterol transport [GO:0030301]; cyclodextrin metabolic process [GO:2000900]; endocytosis [GO:0006897]; establishment of protein localization to membrane [GO:0090150]; gene expression [GO:0010467]; intestinal cholesterol absorption [GO:0030299]; intracellular cholesterol transport [GO:0032367]; intracellular lipid transport [GO:0032365]; liver development [GO:0001889]; lysosomal transport [GO:0007041]; macroautophagy [GO:0016236]; membrane raft organization [GO:0031579]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of macroautophagy [GO:0016242]; negative regulation of TORC1 signaling [GO:1904262]; neurogenesis [GO:0022008]; programmed cell death [GO:0012501]; protein glycosylation [GO:0006486]; response to cadmium ion [GO:0046686]; response to xenobiotic stimulus [GO:0009410]; symbiont entry into host cell [GO:0046718] | endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] | cholesterol binding [GO:0015485]; signaling receptor activity [GO:0038023]; sterol transporter activity [GO:0015248]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618] | 15496.84505725845 | 0.213898420829944 | 0.0104473999330752 | 0.049009025271087 |
| Q12797 | Q12797 | ASPH_HUMAN | Aspartyl/asparaginyl beta-hydroxylase (EC 1.14.11.16) (Aspartate beta-hydroxylase) (ASP beta-hydroxylase) (Peptide-aspartate beta-dioxygenase) | ASPH | activation of cysteine-type endopeptidase activity [GO:0097202]; activation of store-operated calcium channel activity [GO:0032237]; calcium ion homeostasis [GO:0055074]; calcium ion transmembrane transport [GO:0070588]; cell population proliferation [GO:0008283]; cellular response to calcium ion [GO:0071277]; detection of calcium ion [GO:0005513]; face morphogenesis [GO:0060325]; limb morphogenesis [GO:0035108]; muscle contraction [GO:0006936]; negative regulation of cell population proliferation [GO:0008285]; pattern specification process [GO:0007389]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of proteolysis [GO:0045862]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031585]; regulation of protein depolymerization [GO:1901879]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; response to ATP [GO:0033198]; roof of mouth development [GO:0060021] | calcium channel complex [GO:0034704]; cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; junctional sarcoplasmic reticulum membrane [GO:0014701]; plasma membrane [GO:0005886]; sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017] | calcium ion binding [GO:0005509]; electron transfer activity [GO:0009055]; peptidyl-aspartic acid 3-dioxygenase activity [GO:0062101]; structural constituent of muscle [GO:0008307]; structural molecule activity [GO:0005198]; transmembrane transporter binding [GO:0044325] | 74240.41778312465 | 0.18238705131972 | 0.0104769637744529 | 0.0491004770438793 |
| Q9UN86 | Q9UN86 | G3BP2_HUMAN | Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2) | G3BP2 | cytoplasmic sequestering of NF-kappaB [GO:0007253]; innate immune response [GO:0045087]; mRNA transport [GO:0051028]; positive regulation of stress granule assembly [GO:0062029]; protein homooligomerization [GO:0051260]; Ras protein signal transduction [GO:0007265]; stress granule assembly [GO:0034063] | cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; ribonucleoprotein complex [GO:1990904] | molecular condensate scaffold activity [GO:0140693]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; signaling receptor complex adaptor activity [GO:0030159] | 62445.74139911975 | 0.239776990195839 | 0.0105025673441529 | 0.0491391796630639 |
| Q8WW01 | Q8WW01 | SEN15_HUMAN | tRNA-splicing endonuclease subunit Sen15 (SEN15 homolog) (HsSEN15) (tRNA-intron endonuclease Sen15) | TSEN15 | mRNA processing [GO:0006397]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388] | nucleolus [GO:0005730]; nucleoplasm [GO:0005654] | nucleic acid binding [GO:0003676] | 16112.84883790715 | -0.288755859818691 | 0.0105004444565258 | 0.0491391796630639 |
| Q8NBK3 | Q8NBK3 | SUMF1_HUMAN | Formylglycine-generating enzyme (FGE) (EC 1.8.3.7) (C-alpha-formylglycine-generating enzyme 1) (Sulfatase-modifying factor 1) | SUMF1 | glycosphingolipid catabolic process [GO:0046479]; post-translational protein modification [GO:0043687]; protein oxidation [GO:0018158] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788] | cupric ion binding [GO:1903135]; formylglycine-generating oxidase activity [GO:0120147]; identical protein binding [GO:0042802]; oxidoreductase activity [GO:0016491] | 27391.62029067175 | 0.275896254795711 | 0.0105156725192975 | 0.0491599013979702 |
| O75340 | O75340 | PDCD6_HUMAN | Programmed cell death protein 6 (Apoptosis-linked gene 2 protein homolog) (ALG-2) | PDCD6 | angiogenesis [GO:0001525]; apoptotic signaling pathway [GO:0097190]; cellular response to heat [GO:0034605]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of TOR signaling [GO:0032007]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of protein monoubiquitination [GO:1902527]; response to calcium ion [GO:0051592]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324] | COPII vesicle coat [GO:0030127]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; protein-macromolecule adaptor activity [GO:0030674]; protein-membrane adaptor activity [GO:0043495]; ubiquitin ligase-substrate adaptor activity [GO:1990756] | 67887.0610975584 | -0.21813732051441 | 0.0105992997051653 | 0.0494692192170233 |
| Q8NI22 | Q8NI22 | MCFD2_HUMAN | Multiple coagulation factor deficiency protein 2 (Neural stem cell-derived neuronal survival protein) | MCFD2 | protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] | endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794] | calcium ion binding [GO:0005509] | 421528.863467732 | 0.48287940671911 | 0.0106408302000657 | 0.0496221760605532 |
| P05106 | P05106 | ITB3_HUMAN | Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61) | ITGB3 | activation of protein kinase activity [GO:0032147]; angiogenesis involved in wound healing [GO:0060055]; apolipoprotein A-I-mediated signaling pathway [GO:0038027]; apoptotic cell clearance [GO:0043277]; blood coagulation [GO:0007596]; blood coagulation, fibrin clot formation [GO:0072378]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; cell-substrate junction assembly [GO:0007044]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to mechanical stimulus [GO:0071260]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to xenobiotic stimulus [GO:0071466]; embryo implantation [GO:0007566]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; maintenance of postsynaptic specialization structure [GO:0098880]; mesodermal cell differentiation [GO:0048333]; negative chemotaxis [GO:0050919]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of lipid storage [GO:0010888]; negative regulation of lipid transport [GO:0032369]; negative regulation of lipoprotein metabolic process [GO:0050748]; negative regulation of low-density lipoprotein receptor activity [GO:1905598]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway [GO:1900731]; positive regulation of angiogenesis [GO:0045766]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of glomerular mesangial cell proliferation [GO:0072126]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of T cell migration [GO:2000406]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of bone resorption [GO:0045124]; regulation of extracellular matrix organization [GO:1903053]; regulation of postsynaptic neurotransmitter receptor diffusion trapping [GO:0150054]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation of protein localization [GO:0032880]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of serotonin uptake [GO:0051611]; regulation of trophoblast cell migration [GO:1901163]; response to activity [GO:0014823]; smooth muscle cell migration [GO:0014909]; substrate adhesion-dependent cell spreading [GO:0034446]; symbiont entry into host cell [GO:0046718]; tube development [GO:0035295]; wound healing [GO:0042060]; wound healing, spreading of epidermal cells [GO:0035313] | alpha9-beta1 integrin-ADAM8 complex [GO:0071133]; alphav-beta3 integrin-HMGB1 complex [GO:0035868]; alphav-beta3 integrin-IGF-1-IGF1R complex [GO:0035867]; alphav-beta3 integrin-PKCalpha complex [GO:0035866]; alphav-beta3 integrin-vitronectin complex [GO:0071062]; apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; filopodium membrane [GO:0031527]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; glycinergic synapse [GO:0098690]; integrin alphav-beta3 complex [GO:0034683]; integrin complex [GO:0008305]; lamellipodium membrane [GO:0031258]; melanosome [GO:0042470]; microvillus membrane [GO:0031528]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]; ruffle membrane [GO:0032587]; synapse [GO:0045202] | cell adhesion molecule binding [GO:0050839]; coreceptor activity [GO:0015026]; enzyme binding [GO:0019899]; extracellular matrix binding [GO:0050840]; fibrinogen binding [GO:0070051]; fibronectin binding [GO:0001968]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; platelet-derived growth factor receptor binding [GO:0005161]; protease binding [GO:0002020]; protein disulfide isomerase activity [GO:0003756]; protein kinase C binding [GO:0005080]; vascular endothelial growth factor receptor 2 binding [GO:0043184]; virus receptor activity [GO:0001618] | 19496.80227804285 | 0.379186588417597 | 0.0107034110444477 | 0.0498729662646716 |
| P39060 | P39060 | COIA1_HUMAN | Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1 (NC1)] | COL18A1 | angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; cell adhesion [GO:0007155]; collagen fibril organization [GO:0030199]; endothelial cell morphogenesis [GO:0001886]; negative regulation of cell population proliferation [GO:0008285]; notochord development [GO:0030903]; response to hydrostatic pressure [GO:0051599]; response to xenobiotic stimulus [GO:0009410]; skeletal system development [GO:0001501]; visual perception [GO:0007601] | basement membrane [GO:0005604]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615] | extracellular matrix structural constituent conferring tensile strength [GO:0030020]; metal ion binding [GO:0046872] | 9708.376787952955 | -0.618713107511057 | 0.0107757997603148 | 0.050112105298561 |
| Q86T03 | Q86T03 | PP4P1_HUMAN | Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 1 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase I) (Transmembrane protein 55B) | PIP4P1 | cholesterol metabolic process [GO:0008203]; lysosome localization [GO:0032418]; phosphatidylinositol dephosphorylation [GO:0046856]; phospholipid metabolic process [GO:0006644]; positive regulation of TORC1 signaling [GO:1904263]; proton-transporting V-type ATPase complex assembly [GO:0070070]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to sterol depletion [GO:0006991] | late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886] | phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity [GO:0034597] | 17132.51699075205 | -0.716488475072305 | 0.0107800492766817 | 0.050112105298561 |
| Q04917 | Q04917 | 1433F_HUMAN | 14-3-3 protein eta (Protein AS1) | YWHAH | glucocorticoid catabolic process [GO:0006713]; glucocorticoid receptor signaling pathway [GO:0042921]; intracellular protein transport [GO:0006886]; membrane depolarization during action potential [GO:0086010]; negative regulation of dendrite morphogenesis [GO:0050774]; positive regulation of DNA-templated transcription [GO:0045893]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of neuron differentiation [GO:0045664]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; regulation of sodium ion transport [GO:0002028]; regulation of synaptic plasticity [GO:0048167]; signal transduction [GO:0007165]; substantia nigra development [GO:0021762] | cerebellar granule cell to Purkinje cell synapse [GO:0150048]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intercalated disc [GO:0014704]; plasma membrane [GO:0005886]; presynapse [GO:0098793] | actin binding [GO:0003779]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; insulin-like growth factor receptor binding [GO:0005159]; nuclear glucocorticoid receptor binding [GO:0035259]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325] | 277431.46323622053 | 0.178430255892559 | 0.0107812665652922 | 0.050112105298561 |
| O15155 | O15155 | BET1_HUMAN | BET1 homolog (hBET1) (Golgi vesicular membrane-trafficking protein p18) | BET1 | endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031]; vesicle fusion with Golgi apparatus [GO:0048280] | endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; SNARE complex [GO:0031201]; transport vesicle [GO:0030133] | SNAP receptor activity [GO:0005484] | 15820.51350548855 | -0.597989426574537 | 0.0108089431100807 | 0.0501995669358338 |
| Q9GZT9 | Q9GZT9 | EGLN1_HUMAN | Egl nine homolog 1 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20) | EGLN1 | cardiac muscle tissue morphogenesis [GO:0055008]; cellular response to hypoxia [GO:0071456]; heart trabecula formation [GO:0060347]; intracellular iron ion homeostasis [GO:0006879]; intracellular oxygen homeostasis [GO:0032364]; labyrinthine layer development [GO:0060711]; negative regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051344]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; peptidyl-proline hydroxylation to 4-hydroxy-L-proline [GO:0018401]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of angiogenesis [GO:0045765]; regulation of modification of postsynaptic structure [GO:0099159]; regulation protein catabolic process at postsynapse [GO:0140252]; response to hypoxia [GO:0001666]; response to nitric oxide [GO:0071731]; ventricular septum morphogenesis [GO:0060412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] | 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; enzyme binding [GO:0019899]; ferrous iron binding [GO:0008198]; hypoxia-inducible factor-proline dioxygenase activity [GO:0160082]; L-ascorbic acid binding [GO:0031418]; peptidyl-proline 4-dioxygenase activity [GO:0031545]; peptidyl-proline dioxygenase activity [GO:0031543] | 23205.071403816102 | 0.366612732910343 | 0.0108839313946695 | 0.050506433482553 |
| O60832 | O60832 | DKC1_HUMAN | H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1) | DKC1 | box H/ACA RNA 3'-end processing [GO:0000495]; enzyme-directed rRNA pseudouridine synthesis [GO:0000455]; mRNA pseudouridine synthesis [GO:1990481]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of telomerase RNA localization to Cajal body [GO:1904872]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]; rRNA pseudouridine synthesis [GO:0031118]; scaRNA localization to Cajal body [GO:0090666]; snRNA pseudouridine synthesis [GO:0031120]; telomerase RNA stabilization [GO:0090669]; telomere maintenance via telomerase [GO:0007004] | box H/ACA scaRNP complex [GO:0072589]; box H/ACA snoRNP complex [GO:0031429]; box H/ACA telomerase RNP complex [GO:0090661]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697] | box H/ACA snoRNA binding [GO:0034513]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; telomerase activity [GO:0003720]; telomerase RNA binding [GO:0070034] | 20764.8619977029 | -0.223375687045557 | 0.0111044952148058 | 0.0514456826550203 |
| P48960 | P48960 | AGRE5_HUMAN | Adhesion G protein-coupled receptor E5 (Leukocyte antigen CD97) (CD antigen CD97) [Cleaved into: Adhesion G protein-coupled receptor E5 subunit alpha; Adhesion G protein-coupled receptor E5 subunit beta] | ADGRE5 | adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954] | extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] | calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]; transmembrane signaling receptor activity [GO:0004888] | 7286.878982438545 | 0.553610924309886 | 0.0111724779656463 | 0.0516864899516238 |
| Q8N1G4 | Q8N1G4 | LRC47_HUMAN | Leucine-rich repeat-containing protein 47 | LRRC47 | phenylalanyl-tRNA aminoacylation [GO:0006432] | phenylalanine-tRNA ligase activity [GO:0004826]; RNA binding [GO:0003723] | 37361.649798487095 | -0.186675838738996 | 0.0111835469162611 | 0.0516864899516238 | |
| Q86TM6 | Q86TM6 | SYVN1_HUMAN | E3 ubiquitin-protein ligase synoviolin (EC 2.3.2.27) (RING-type E3 ubiquitin transferase synoviolin) (Synovial apoptosis inhibitor 1) | SYVN1 | ERAD pathway [GO:0036503]; immature B cell differentiation [GO:0002327]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; protein K48-linked ubiquitination [GO:0070936]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent protein catabolic process [GO:0006511] | cytoplasm [GO:0005737]; Derlin-1 retrotranslocation complex [GO:0036513]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; Hrd1p ubiquitin ligase complex [GO:0000836]; Hrd1p ubiquitin ligase ERAD-L complex [GO:0000839]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; smooth endoplasmic reticulum [GO:0005790] | ATPase binding [GO:0051117]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-specific protease binding [GO:1990381]; unfolded protein binding [GO:0051082] | 7693.312347762239 | -0.21485142492186 | 0.0111929620844762 | 0.0516864899516238 |
| Q9P121 | Q9P121 | NTRI_HUMAN | Neurotrimin (hNT) (IgLON family member 2) | NTM | cell adhesion [GO:0007155]; neuron recognition [GO:0008038] | extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] | 3231.09246059433 | -0.943697101416727 | 0.0112444266898553 | 0.0518818580005865 | |
| Q9Y2V2 | Q9Y2V2 | CHSP1_HUMAN | Calcium-regulated heat-stable protein 1 (Calcium-regulated heat-stable protein of 24 kDa) (CRHSP-24) | CARHSP1 | intracellular signal transduction [GO:0035556]; regulation of mRNA stability [GO:0043488] | cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; P granule [GO:0043186]; P-body [GO:0000932] | mRNA 3'-UTR binding [GO:0003730]; phosphatase binding [GO:0019902] | 239215.571933601 | 0.418340925382254 | 0.0112918435619496 | 0.0520217060995559 |
| Q5ZPR3 | Q5ZPR3 | CD276_HUMAN | CD276 antigen (4Ig-B7-H3) (B7 homolog 3) (B7-H3) (Costimulatory molecule) (CD antigen CD276) | CD276 | positive regulation of T cell proliferation [GO:0042102]; positive regulation of type II interferon production [GO:0032729]; regulation of cytokine production [GO:0001817]; regulation of immune response [GO:0050776]; T cell activation [GO:0042110]; T cell receptor signaling pathway [GO:0050852] | external side of plasma membrane [GO:0009897]; membrane [GO:0016020] | signaling receptor binding [GO:0005102] | 14738.47979162385 | 0.454704200004553 | 0.0112930989238358 | 0.0520217060995559 |
| P62826 | P62826 | RAN_HUMAN | GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein) | RAN | actin cytoskeleton organization [GO:0030036]; cell division [GO:0051301]; cellular response to mineralocorticoid stimulus [GO:0071389]; DNA metabolic process [GO:0006259]; GTP metabolic process [GO:0046039]; hippocampus development [GO:0021766]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle organization [GO:0007052]; positive regulation of protein binding [GO:0032092]; positive regulation of protein import into nucleus [GO:0042307]; pre-miRNA export from nucleus [GO:0035281]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; protein localization to nucleolus [GO:1902570]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit export from nucleus [GO:0000056]; ribosomal subunit export from nucleus [GO:0000054]; snRNA import into nucleus [GO:0061015]; spermatid development [GO:0007286]; viral process [GO:0016032] | centriole [GO:0005814]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; male germ cell nucleus [GO:0001673]; manchette [GO:0002177]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037]; RNA nuclear export complex [GO:0042565]; sperm flagellum [GO:0036126] | cadherin binding [GO:0045296]; chromatin binding [GO:0003682]; dynein intermediate chain binding [GO:0045505]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; importin-alpha family protein binding [GO:0061676]; magnesium ion binding [GO:0000287]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723] | 301147.053437872 | 0.229048621249171 | 0.0113074236477721 | 0.0520453796817844 |
| P31944 | P31944 | CASPE_HUMAN | Caspase-14 (CASP-14) (EC 3.4.22.-) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form] | CASP14 | cornification [GO:0070268]; epidermis development [GO:0008544]; keratinization [GO:0031424]; positive regulation of neuron apoptotic process [GO:0043525]; proteolysis [GO:0006508] | cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; keratin filament [GO:0045095]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | cysteine-type endopeptidase activity [GO:0004197] | 4386.460092464875 | -2.67035591869661 | 0.0113238761481053 | 0.0520788005317893 |
| O60888 | O60888 | CUTA_HUMAN | Protein CutA (Acetylcholinesterase-associated protein) (Brain acetylcholinesterase putative membrane anchor) | CUTA | protein localization [GO:0008104]; response to metal ion [GO:0010038] | extracellular exosome [GO:0070062]; membrane [GO:0016020] | copper ion binding [GO:0005507]; enzyme binding [GO:0019899] | 42205.36883652875 | -0.642278829257106 | 0.0114404494964051 | 0.0525722521059457 |
| P06730 | P06730 | IF4E_HUMAN | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) | EIF4E | behavioral fear response [GO:0001662]; cellular response to dexamethasone stimulus [GO:0071549]; G1/S transition of mitotic cell cycle [GO:0000082]; mRNA export from nucleus [GO:0006406]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of translation [GO:0017148]; neuron differentiation [GO:0030182]; positive regulation of mitotic cell cycle [GO:0045931]; regulation of translation [GO:0006417]; regulation of translation at postsynapse, modulating synaptic transmission [GO:0099578]; stem cell population maintenance [GO:0019827]; translational initiation [GO:0006413] | chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794]; RISC complex [GO:0016442] | DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; eukaryotic initiation factor 4G binding [GO:0031370]; mRNA cap binding [GO:0098808]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; translation initiation factor activity [GO:0003743] | 138511.835854835 | 0.271014916633847 | 0.011566303974609 | 0.0531075188980021 |
| Q9NRY5 | Q9NRY5 | F1142_HUMAN | Protein FAM114A2 | FAM114A2 | purine nucleotide binding [GO:0017076] | 16024.944644053601 | 0.241020099763902 | 0.0115894862519941 | 0.0531278552619732 | ||
| Q9BQE4 | Q9BQE4 | SELS_HUMAN | Selenoprotein S (SelS) (VCP-interacting membrane protein) | SELENOS | cell redox homeostasis [GO:0045454]; cellular response to insulin stimulus [GO:0032869]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to oxidative stress [GO:0034599]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER overload response [GO:0006983]; ERAD pathway [GO:0036503]; establishment of protein localization [GO:0045184]; negative regulation of acute inflammatory response to antigenic stimulus [GO:0002865]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of glucose import [GO:0046325]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of macrophage apoptotic process [GO:2000110]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of tumor necrosis factor production [GO:0032720]; regulation of gluconeogenesis [GO:0006111]; regulation of nitric oxide metabolic process [GO:0080164]; response to glucose [GO:0009749]; response to redox state [GO:0051775]; retrograde protein transport, ER to cytosol [GO:0030970] | cytoplasmic microtubule [GO:0005881]; Derlin-1 retrotranslocation complex [GO:0036513]; Derlin-1-VIMP complex [GO:0036502]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; low-density lipoprotein particle [GO:0034362]; plasma membrane [GO:0005886]; very-low-density lipoprotein particle [GO:0034361] | antioxidant activity [GO:0016209]; ATPase binding [GO:0051117]; enzyme binding [GO:0019899]; signaling receptor activity [GO:0038023]; ubiquitin-specific protease binding [GO:1990381] | 26312.85989957615 | 0.391933850865174 | 0.0115822888377265 | 0.0531278552619732 |
| O75955 | O75955 | FLOT1_HUMAN | Flotillin-1 | FLOT1 | axonogenesis [GO:0007409]; cellular response to exogenous dsRNA [GO:0071360]; dsRNA transport [GO:0033227]; extracellular matrix disassembly [GO:0022617]; plasma membrane raft assembly [GO:0044854]; plasma membrane raft organization [GO:0044857]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell junction assembly [GO:1901890]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of cytokine production [GO:0001819]; positive regulation of endocytosis [GO:0045807]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; protein kinase C signaling [GO:0070528]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; regulation of neurotransmitter uptake [GO:0051580]; regulation of receptor internalization [GO:0002090]; regulation of Rho protein signal transduction [GO:0035023]; response to endoplasmic reticulum stress [GO:0034976] | adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; cytoplasmic vesicle [GO:0031410]; dopaminergic synapse [GO:0098691]; early endosome [GO:0005769]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; membrane raft [GO:0045121]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; sarcolemma [GO:0042383]; uropod [GO:0001931] | ionotropic glutamate receptor binding [GO:0035255]; protease binding [GO:0002020] | 35685.709130358504 | 0.151284959671472 | 0.0118344220887893 | 0.0541682503369541 |
| Q96P16 | Q96P16 | RPR1A_HUMAN | Regulation of nuclear pre-mRNA domain-containing protein 1A (Cyclin-dependent kinase inhibitor 2B-related protein) (p15INK4B-related protein) | RPRD1A | mRNA 3'-end processing [GO:0031124]; RNA polymerase II promoter clearance [GO:0001111] | nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription preinitiation complex [GO:0097550] | identical protein binding [GO:0042802]; RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II complex binding [GO:0000993] | 12299.52591533535 | 0.352992702436898 | 0.0118355619338421 | 0.0541682503369541 |
| P61204 | P61204 | ARF3_HUMAN | ADP-ribosylation factor 3 | ARF3 | intracellular protein transport [GO:0006886]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle-mediated transport [GO:0016192] | extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] | GTP binding [GO:0005525]; GTPase activity [GO:0003924] | 176435.59817489499 | -0.273181902854503 | 0.0118771409438684 | 0.0543146735980295 |
| Q9P258 | Q9P258 | RCC2_HUMAN | Protein RCC2 (RCC1-like protein TD-60) (Telophase disk protein of 60 kDa) | RCC2 | cell cycle [GO:0007049]; cell division [GO:0051301]; chromosome passenger complex localization to kinetochore [GO:0072356]; establishment of protein localization [GO:0045184]; focal adhesion assembly [GO:0048041]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of GTPase activity [GO:0034260]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; positive regulation of attachment of spindle microtubules to kinetochore [GO:0051987]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; regulation of cell migration [GO:0030334]; regulation of fibroblast migration [GO:0010762]; regulation of ruffle assembly [GO:1900027] | chromosome, centromeric core domain [GO:0034506]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] | guanyl-nucleotide exchange factor activity [GO:0005085]; microtubule binding [GO:0008017]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267] | 15772.038185942649 | -0.371469539295808 | 0.0119219220889735 | 0.0544754923839709 |
| P09132 | P09132 | SRP19_HUMAN | Signal recognition particle 19 kDa protein (SRP19) | SRP19 | cotranslational protein targeting to membrane [GO:0006613]; SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [GO:0006617] | cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; signal recognition particle [GO:0048500]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786] | 7S RNA binding [GO:0008312]; RNA binding [GO:0003723] | 29696.6796187777 | 0.309574983731349 | 0.0119997525443779 | 0.0547869443323491 |
| Q9ULP9 | Q9ULP9 | TBC24_HUMAN | TBC1 domain family member 24 | TBC1D24 | axon development [GO:0061564]; cellular response to oxidative stress [GO:0034599]; dendrite development [GO:0016358]; negative regulation of cellular response to oxidative stress [GO:1900408]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; neuron projection development [GO:0031175]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of neuron migration [GO:2001224]; synaptic vesicle endocytosis [GO:0048488] | cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; neuromuscular junction [GO:0031594]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; terminal bouton [GO:0043195] | GTPase activator activity [GO:0005096] | 8581.792301629375 | -0.320990067637003 | 0.0120988971093788 | 0.0551951296471338 |
| Q6UW63 | Q6UW63 | PLGT2_HUMAN | Protein O-glucosyltransferase 2 (EC 2.4.1.-) (Endoplasmic reticulum resident protein 58) (ER protein 58) (ERp58) (KDEL motif-containing protein 1) (Protein O-xylosyltransferase POGLUT2) (EC 2.4.2.-) | POGLUT2 | protein O-linked glycosylation via serine [GO:0018242] | cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum lumen [GO:0005788]; nucleoplasm [GO:0005654] | EGF-domain serine glucosyltransferase activity [GO:0140561]; EGF-domain serine xylosyltransferase activity [GO:0140562]; glucosyltransferase activity [GO:0046527]; UDP-glucosyltransferase activity [GO:0035251]; UDP-xylosyltransferase activity [GO:0035252] | 10746.6146168169 | 0.162808417943435 | 0.0121800274378786 | 0.0553760096463047 |
| Q99873 | Q99873 | ANM1_HUMAN | Protein arginine N-methyltransferase 1 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT1) (Interferon receptor 1-bound protein 4) | PRMT1 | cardiac muscle tissue development [GO:0048738]; cell surface receptor signaling pathway [GO:0007166]; cellular response to methionine [GO:0061431]; in utero embryonic development [GO:0001701]; negative regulation of JNK cascade [GO:0046329]; negative regulation of megakaryocyte differentiation [GO:0045653]; neuron projection development [GO:0031175]; peptidyl-arginine methylation [GO:0018216]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of hemoglobin biosynthetic process [GO:0046985]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of translation [GO:0045727]; protein homooligomerization [GO:0051260]; protein methylation [GO:0006479]; regulation of BMP signaling pathway [GO:0030510]; regulation of megakaryocyte differentiation [GO:0045652]; RNA splicing [GO:0008380]; viral protein processing [GO:0019082] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | enzyme binding [GO:0019899]; GATOR1 complex binding [GO:0106080]; histone H4R3 methyltransferase activity [GO:0044020]; histone methyltransferase activity [GO:0042054]; identical protein binding [GO:0042802]; methyl-CpG binding [GO:0008327]; methyltransferase activity [GO:0008168]; mitogen-activated protein kinase p38 binding [GO:0048273]; N-methyltransferase activity [GO:0008170]; protein methyltransferase activity [GO:0008276]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; protein-arginine omega-N monomethyltransferase activity [GO:0035241]; RNA binding [GO:0003723]; S-adenosyl-L-methionine binding [GO:1904047] | 48711.15511266375 | 0.218775084090816 | 0.0121874133478542 | 0.0553760096463047 |
| P53007 | P53007 | TXTP_HUMAN | Tricarboxylate transport protein, mitochondrial (Citrate transport protein) (CTP) (Mitochondrial citrate carrier) (CIC) (Solute carrier family 25 member 1) (Tricarboxylate carrier protein) | SLC25A1 | fatty-acyl-CoA biosynthetic process [GO:0046949]; gluconeogenesis [GO:0006094]; mitochondrial citrate transmembrane transport [GO:0006843] | extracellular exosome [GO:0070062]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634] | antiporter activity [GO:0015297]; citrate secondary active transmembrane transporter activity [GO:0071913]; citrate transmembrane transporter activity [GO:0015137]; tricarboxylic acid transmembrane transporter activity [GO:0015142] | 82308.11449959675 | -0.181576657673614 | 0.0121733702582214 | 0.0553760096463047 |
| Q8NFX7 | Q8NFX7 | STXB6_HUMAN | Syntaxin-binding protein 6 (Amisyn) | STXBP6 | exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; negative regulation of exocytosis [GO:0045920]; regulation of SNARE complex assembly [GO:0035542]; SNARE complex assembly [GO:0035493] | adherens junction [GO:0005912]; exocyst [GO:0000145]; plasma membrane [GO:0005886] | cadherin binding involved in cell-cell adhesion [GO:0098641]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546] | 13971.505701641101 | 0.905549105116076 | 0.0121863139584119 | 0.0553760096463047 |
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