Selected Cell
Cell:
Value:
stat_data__min_2_Peptides
Sheet1
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| Q6ZS17 | Q6ZS17 | RIPR1_HUMAN | Rho family-interacting cell polarization regulator 1 | RIPOR1 | cellular response to chemokine [GO:1990869]; cellular response to starvation [GO:0009267]; establishment of Golgi localization [GO:0051683]; negative regulation of Rho guanyl-nucleotide exchange factor activity [GO:2001107]; negative regulation of Rho protein signal transduction [GO:0035024]; positive regulation of cell migration [GO:0030335]; positive regulation of intracellular protein transport [GO:0090316]; protein localization to Golgi apparatus [GO:0034067]; response to wounding [GO:0009611]; Rho protein signal transduction [GO:0007266] | cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; vesicle membrane [GO:0012506] | 14-3-3 protein binding [GO:0071889] | 5409.2515128633095 | 0.548519055587952 | 8.41376664206205E-4 | 0.00592940320819945 |
| Q9NUQ9 | Q9NUQ9 | CYRIB_HUMAN | CYFIP-related Rac1 interactor B (L1) | CYRIB | cellular response to molecule of bacterial origin [GO:0071219]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; positive regulation of memory T cell activation [GO:2000568]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of type II interferon production [GO:0032729]; regulation of cell migration [GO:0030334]; regulation of chemotaxis [GO:0050920]; regulation of establishment of cell polarity [GO:2000114]; regulation of mitochondrial fission [GO:0090140] | cilium [GO:0005929]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrion [GO:0005739]; platelet alpha granule lumen [GO:0031093] | MHC class Ib protein binding, via antigen binding groove [GO:0023030]; small GTPase binding [GO:0031267] | 46879.2665428015 | 0.219789741461552 | 8.47949188005121E-4 | 0.00596829825992176 |
| P17844 | P17844 | DDX5_HUMAN | Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) | DDX5 | alternative mRNA splicing, via spliceosome [GO:0000380]; androgen receptor signaling pathway [GO:0030521]; BMP signaling pathway [GO:0030509]; epithelial to mesenchymal transition [GO:0001837]; intracellular estrogen receptor signaling pathway [GO:0030520]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; miRNA transcription [GO:0061614]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transcription [GO:0009299]; myoblast differentiation [GO:0045445]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear-transcribed mRNA catabolic process [GO:0000956]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; primary miRNA processing [GO:0031053]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of osteoblast differentiation [GO:0045667]; regulation of skeletal muscle cell differentiation [GO:2001014]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of viral genome replication [GO:0045069]; rhythmic process [GO:0048511] | catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; MH2 domain binding [GO:0035500]; mRNA 3'-UTR binding [GO:0003730]; nuclear androgen receptor binding [GO:0050681]; pre-mRNA binding [GO:0036002]; primary miRNA binding [GO:0070878]; promoter-specific chromatin binding [GO:1990841]; R-SMAD binding [GO:0070412]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; SMAD binding [GO:0046332] | 36834.1674977054 | 0.128707882054541 | 8.49526050123433E-4 | 0.00597197841190989 |
| Q5W0V3 | Q5W0V3 | FHI2A_HUMAN | FHF complex subunit HOOK interacting protein 2A (FHIP2A) | FHIP2A | 7701.78492884527 | -0.351386327454134 | 8.57158455903977E-4 | 0.00601816581307551 | |||
| P49757 | P49757 | NUMB_HUMAN | Protein numb homolog (h-Numb) (Protein S171) | NUMB | adherens junction organization [GO:0034332]; axonogenesis [GO:0007409]; lateral ventricle development [GO:0021670]; negative regulation of protein localization to plasma membrane [GO:1903077]; neuroblast division in subventricular zone [GO:0021849]; positive regulation of cell migration [GO:0030335]; positive regulation of neurogenesis [GO:0050769]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149] | apical part of cell [GO:0045177]; basolateral plasma membrane [GO:0016323]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886] | alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296] | 34297.40067866195 | 0.304302664995394 | 8.61259956634112E-4 | 0.00603947885431792 |
| Q9BUT1 | Q9BUT1 | DHRS6_HUMAN | Dehydrogenase/reductase SDR family member 6 (EC 1.1.1.-) ((R)-beta-hydroxybutyrate dehydrogenase) (3-hydroxybutyrate dehydrogenase type 2) (EC 1.1.1.30) (4-oxo-L-proline reductase) (EC 1.1.1.104) (Oxidoreductase UCPA) (Short chain dehydrogenase/reductase family 15C member 1) | BDH2 | epithelial cell differentiation [GO:0030855]; fatty acid beta-oxidation [GO:0006635]; heme metabolic process [GO:0042168]; intracellular sequestering of iron ion [GO:0006880]; siderophore biosynthetic process [GO:0019290] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] | 3-hydroxybutyrate dehydrogenase activity [GO:0003858]; 4-oxoproline reductase activity [GO:0016617]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628] | 46599.71523018705 | -0.598521813686963 | 8.62899502885848E-4 | 0.0060434963947481 |
| O00584 | O00584 | RNT2_HUMAN | Ribonuclease T2 (EC 4.6.1.19) (Ribonuclease 6) | RNASET2 | innate immune response [GO:0045087]; RNA catabolic process [GO:0006401] | azurophil granule lumen [GO:0035578]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; mitochondrial intermembrane space [GO:0005758] | ribonuclease T2 activity [GO:0033897]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; RNA nuclease activity [GO:0004540] | 19003.701787477752 | 0.618438978466023 | 8.71146341621071E-4 | 0.00609372243410493 |
| Q70UQ0 | Q70UQ0 | IKIP_HUMAN | Inhibitor of nuclear factor kappa-B kinase-interacting protein (I kappa-B kinase-interacting protein) (IKBKB-interacting protein) (IKK-interacting protein) | IKBIP | response to X-ray [GO:0010165] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleolus [GO:0005730] | 87386.72163740851 | 0.271950757945437 | 8.75670526069526E-4 | 0.00611781652368672 | |
| Q9UBQ5 | Q9UBQ5 | EIF3K_HUMAN | Eukaryotic translation initiation factor 3 subunit K (eIF3k) (Eukaryotic translation initiation factor 3 subunit 12) (Muscle-specific gene M9 protein) (PLAC-24) (eIF-3 p25) (eIF-3 p28) | EIF3K | formation of cytoplasmic translation initiation complex [GO:0001732]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413] | cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; membrane [GO:0016020]; nucleus [GO:0005634] | ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] | 31816.0293523693 | -0.44176541198686 | 8.80395925654545E-4 | 0.00614325531374218 |
| P08574 | P08574 | CY1_HUMAN | Cytochrome c1, heme protein, mitochondrial (EC 7.1.1.8) (Complex III subunit 4) (Complex III subunit IV) (Cytochrome b-c1 complex subunit 4) (Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit) (Cytochrome c-1) | CYC1 | cellular respiration [GO:0045333]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; response to glucagon [GO:0033762] | membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex III [GO:0005750]; mitochondrion [GO:0005739]; nucleus [GO:0005634] | heme binding [GO:0020037]; metal ion binding [GO:0046872]; ubiquinol-cytochrome-c reductase activity [GO:0008121] | 18919.03690187075 | 0.437574760547621 | 8.83578826540906E-4 | 0.00615683026897521 |
| P07305 | P07305 | H10_HUMAN | Histone H1.0 (Histone H1') (Histone H1(0)) [Cleaved into: Histone H1.0, N-terminally processed] | H1-0 | chromosome condensation [GO:0030261]; heterochromatin formation [GO:0031507]; negative regulation of DNA recombination [GO:0045910]; nucleosome assembly [GO:0006334]; positive regulation of transcription regulatory region DNA binding [GO:2000679] | actin cytoskeleton [GO:0015629]; chromatin [GO:0000785]; euchromatin [GO:0000791]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] | chromatin DNA binding [GO:0031490]; double-stranded DNA binding [GO:0003690]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; nucleosomal DNA binding [GO:0031492]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723]; structural constituent of chromatin [GO:0030527] | 31896.373959071898 | 0.545518979028844 | 8.8451462035754E-4 | 0.00615683026897521 |
| Q9Y316 | Q9Y316 | MEMO1_HUMAN | Protein MEMO1 (C21orf19-like protein) (Hepatitis C virus NS5A-transactivated protein 7) (HCV NS5A-transactivated protein 7) (Mediator of ErbB2-driven cell motility 1) (Mediator of cell motility 1) (Memo-1) | MEMO1 | regulation of microtubule-based process [GO:0032886] | cytosol [GO:0005829]; nucleus [GO:0005634] | 12797.734702423251 | 0.211141538029655 | 8.91392118039152E-4 | 0.0061970892525274 | |
| Q15392 | Q15392 | DHC24_HUMAN | Delta(24)-sterol reductase (EC 1.3.1.72) (24-dehydrocholesterol reductase) (3-beta-hydroxysterol Delta-24-reductase) (Diminuto/dwarf1 homolog) (Seladin-1) | DHCR24 | amyloid precursor protein catabolic process [GO:0042987]; cholesterol biosynthetic process [GO:0006695]; cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]; male genitalia development [GO:0030539]; membrane organization [GO:0061024]; negative regulation of cell population proliferation [GO:0008285]; plasminogen activation [GO:0031639]; protein localization [GO:0008104]; Ras protein signal transduction [GO:0007265]; response to hormone [GO:0009725]; skin development [GO:0043588]; steroid metabolic process [GO:0008202]; tissue development [GO:0009888] | cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleus [GO:0005634] | delta24(24-1) sterol reductase activity [GO:0000246]; delta24-sterol reductase activity [GO:0050614]; enzyme binding [GO:0019899]; FAD binding [GO:0071949]; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628]; peptide antigen binding [GO:0042605] | 11248.52181553775 | -0.711912289190736 | 9.08239477931854E-4 | 0.00630647657103172 |
| O95219 | O95219 | SNX4_HUMAN | Sorting nexin-4 | SNX4 | endocytic recycling [GO:0032456]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of histamine secretion by mast cell [GO:1903595]; protein transport [GO:0015031] | cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic endosome [GO:0098830]; protein-containing complex [GO:0032991]; SNARE complex [GO:0031201] | epidermal growth factor receptor binding [GO:0005154]; insulin receptor binding [GO:0005158]; leptin receptor binding [GO:1990460]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3-phosphate binding [GO:0032266]; transferrin receptor binding [GO:1990459] | 14498.915491425 | -0.264631534193497 | 9.1088834738917E-4 | 0.00631712775557777 |
| P41226 | P41226 | UBA7_HUMAN | Ubiquitin-like modifier-activating enzyme 7 (Ubiquitin-activating enzyme 7) (EC 6.2.1.-) (D8) (Ubiquitin-activating enzyme E1 homolog) | UBA7 | DNA damage response [GO:0006974]; innate immune response [GO:0045087]; ISG15-protein conjugation [GO:0032020]; modification-dependent protein catabolic process [GO:0019941]; protein modification process [GO:0036211]; protein ubiquitination [GO:0016567] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] | ATP binding [GO:0005524]; ISG15 activating enzyme activity [GO:0019782]; ubiquitin-protein transferase activity [GO:0004842] | 9069.321517232815 | 0.40008051106075 | 9.13257309980935E-4 | 0.00632581408111489 |
| Q08211 | Q08211 | DHX9_HUMAN | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) | DHX9 | alternative mRNA splicing, via spliceosome [GO:0000380]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to tumor necrosis factor [GO:0071356]; CRD-mediated mRNA stabilization [GO:0070934]; DNA duplex unwinding [GO:0032508]; DNA replication [GO:0006260]; DNA-templated transcription termination [GO:0006353]; DNA-templated viral transcription [GO:0039695]; G-quadruplex DNA unwinding [GO:0044806]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; mRNA transport [GO:0051028]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; osteoblast differentiation [GO:0001649]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [GO:2000373]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of inflammatory response [GO:0050729]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of RNA export from nucleus [GO:0046833]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of viral transcription [GO:0050434]; protein localization to cytoplasmic stress granule [GO:1903608]; protein-containing complex assembly [GO:0065003]; pyroptosis [GO:0070269]; regulation of cytoplasmic translation [GO:2000765]; regulation of defense response to virus by host [GO:0050691]; regulation of mRNA processing [GO:0050684]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511]; RISC complex assembly [GO:0070922]; RNA secondary structure unwinding [GO:0010501] | actin cytoskeleton [GO:0015629]; centrosome [GO:0005813]; CRD-mediated mRNA stability complex [GO:0070937]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nuclear stress granule [GO:0097165]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578] | 3'-5' DNA helicase activity [GO:0043138]; 3'-5' DNA/RNA helicase activity [GO:0033679]; 3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; DNA replication origin binding [GO:0003688]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; importin-alpha family protein binding [GO:0061676]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; nucleoside triphosphate diphosphatase activity [GO:0047429]; polysome binding [GO:1905538]; promoter-specific chromatin binding [GO:1990841]; regulatory region RNA binding [GO:0001069]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; ribosome binding [GO:0043022]; RISC complex binding [GO:1905172]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA polymerase binding [GO:0070063]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II complex binding [GO:0000993]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; RNA stem-loop binding [GO:0035613]; sequence-specific mRNA binding [GO:1990825]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; siRNA binding [GO:0035197]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; triplex DNA binding [GO:0045142] | 37045.595384329805 | -0.186860630284684 | 9.17965437715604E-4 | 0.00634571752701031 |
| P49184 | P49184 | DNSL1_HUMAN | Deoxyribonuclease-1-like 1 (EC 3.1.21.-) (DNase X) (Deoxyribonuclease I-like 1) (DNase I-like 1) (Muscle-specific DNase I-like) (XIB) | DNASE1L1 | DNA catabolic process [GO:0006308]; DNA metabolic process [GO:0006259] | endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; nucleus [GO:0005634]; specific granule lumen [GO:0035580] | deoxyribonuclease I activity [GO:0004530]; DNA binding [GO:0003677]; DNA nuclease activity [GO:0004536] | 30257.3052001276 | -0.331140710490793 | 9.18370697520024E-4 | 0.00634571752701031 |
| P84095 | P84095 | RHOG_HUMAN | Rho-related GTP-binding protein RhoG | RHOG | actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; activation of GTPase activity [GO:0090630]; cell chemotaxis [GO:0060326]; cortical cytoskeleton organization [GO:0030865]; engulfment of apoptotic cell [GO:0043652]; establishment or maintenance of cell polarity [GO:0007163]; motor neuron axon guidance [GO:0008045]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein localization to plasma membrane [GO:1903078]; Rac protein signal transduction [GO:0016601]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; regulation of ruffle assembly [GO:1900027]; Rho protein signal transduction [GO:0007266] | cell projection [GO:0042995]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] | GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901] | 46919.67157103275 | -0.276743524872132 | 9.44720869468549E-4 | 0.00651983976420073 |
| P62166 | P62166 | NCS1_HUMAN | Neuronal calcium sensor 1 (NCS-1) (Frequenin homolog) (Frequenin-like protein) (Frequenin-like ubiquitous protein) | NCS1 | regulation of neuron projection development [GO:0010975] | axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] | calcium ion binding [GO:0005509]; calcium sensitive guanylate cyclase activator activity [GO:0008048]; voltage-gated calcium channel activity [GO:0005245] | 10723.8479283861 | 0.521511289331056 | 9.53057544418631E-4 | 0.00656937231955713 |
| P36957 | P36957 | ODO2_HUMAN | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K) | DLST | 2-oxoglutarate metabolic process [GO:0006103]; generation of precursor metabolites and energy [GO:0006091]; histone succinylation [GO:0106077]; L-lysine catabolic process to acetyl-CoA via saccharopine [GO:0033512]; succinyl-CoA metabolic process [GO:0006104]; tricarboxylic acid cycle [GO:0006099] | cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; oxoglutarate dehydrogenase complex [GO:0045252] | acyltransferase activity [GO:0016746]; dihydrolipoyllysine-residue succinyltransferase activity [GO:0004149] | 36234.71646383725 | 0.361641600545333 | 9.6174028804351E-4 | 0.00662116703773333 |
| Q9NS69 | Q9NS69 | TOM22_HUMAN | Mitochondrial import receptor subunit TOM22 homolog (hTom22) (1C9-2) (Translocase of outer membrane 22 kDa subunit homolog) | TOMM22 | protein insertion into mitochondrial outer membrane [GO:0045040]; protein targeting to mitochondrion [GO:0006626] | membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; TOM complex [GO:0140596] | mitochondrion targeting sequence binding [GO:0030943]; protein transmembrane transporter activity [GO:0008320] | 43609.99009884365 | -0.564683935434236 | 9.65801930180514E-4 | 0.00664106035971212 |
| P00441 | P00441 | SODC_HUMAN | Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Superoxide dismutase 1) (hSod1) | SOD1 | action potential initiation [GO:0099610]; anterograde axonal transport [GO:0008089]; apoptotic process [GO:0006915]; auditory receptor cell stereocilium organization [GO:0060088]; determination of adult lifespan [GO:0008340]; ectopic germ cell programmed cell death [GO:0035234]; embryo implantation [GO:0007566]; gene expression [GO:0010467]; glutathione metabolic process [GO:0006749]; heart contraction [GO:0060047]; hydrogen peroxide biosynthetic process [GO:0050665]; intracellular iron ion homeostasis [GO:0006879]; locomotory behavior [GO:0007626]; muscle cell cellular homeostasis [GO:0046716]; myeloid cell homeostasis [GO:0002262]; negative regulation of cholesterol biosynthetic process [GO:0045541]; negative regulation of developmental process [GO:0051093]; negative regulation of inflammatory response [GO:0050728]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of reproductive process [GO:2000242]; neurofilament cytoskeleton organization [GO:0060052]; neuronal action potential [GO:0019228]; ovarian follicle development [GO:0001541]; peripheral nervous system myelin maintenance [GO:0032287]; placenta development [GO:0001890]; positive regulation of apoptotic process [GO:0043065]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cytokine production [GO:0001819]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of phagocytosis [GO:0050766]; positive regulation of superoxide anion generation [GO:0032930]; reactive oxygen species metabolic process [GO:0072593]; regulation of blood pressure [GO:0008217]; regulation of GTPase activity [GO:0043087]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of multicellular organism growth [GO:0040014]; regulation of organ growth [GO:0046620]; regulation of protein kinase activity [GO:0045859]; regulation of T cell differentiation in thymus [GO:0033081]; relaxation of vascular associated smooth muscle [GO:0060087]; removal of superoxide radicals [GO:0019430]; response to axon injury [GO:0048678]; response to ethanol [GO:0045471]; response to heat [GO:0009408]; response to hydrogen peroxide [GO:0042542]; response to organic substance [GO:0010033]; response to superoxide [GO:0000303]; response to xenobiotic stimulus [GO:0009410]; retina homeostasis [GO:0001895]; retrograde axonal transport [GO:0008090]; sensory perception of sound [GO:0007605]; spermatogenesis [GO:0007283]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]; thymus development [GO:0048538]; transmission of nerve impulse [GO:0019226] | axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991] | copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; protein phosphatase 2B binding [GO:0030346]; protein-folding chaperone binding [GO:0051087]; small GTPase binding [GO:0031267]; superoxide dismutase activity [GO:0004784]; zinc ion binding [GO:0008270] | 396617.769505168 | 0.644393808079664 | 9.76494520302135E-4 | 0.0067064460024629 |
| P78357 | P78357 | CNTP1_HUMAN | Contactin-associated protein 1 (Caspr) (Caspr1) (Neurexin IV) (Neurexin-4) (p190) | CNTNAP1 | axonogenesis [GO:0007409]; cell adhesion [GO:0007155]; central nervous system myelination [GO:0022010]; cytoskeleton organization [GO:0007010]; mitochondrion organization [GO:0007005]; myelination in peripheral nervous system [GO:0022011]; neuromuscular junction development, skeletal muscle fiber [GO:0098529]; neuromuscular process controlling balance [GO:0050885]; neuromuscular process controlling posture [GO:0050884]; neuron projection morphogenesis [GO:0048812]; neuronal action potential propagation [GO:0019227]; paranodal junction assembly [GO:0030913]; paranodal junction maintenance [GO:1990227]; postsynaptic density organization [GO:0097106]; protein localization to juxtaparanode region of axon [GO:0071205]; protein localization to paranode region of axon [GO:0002175]; regulation of synapse maturation [GO:0090128]; signal transduction [GO:0007165] | glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; paranodal junction [GO:0033010]; paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786] | SH3 domain binding [GO:0017124]; signaling receptor activity [GO:0038023] | 16980.907591568 | 0.163162495738214 | 9.80485019128615E-4 | 0.00672569990118975 |
| Q96KS9 | Q96KS9 | F167A_HUMAN | Protein FAM167A | FAM167A | 18317.2066496 | 0.638734959921995 | 9.96396454761875E-4 | 0.00682658078921497 | |||
| Q9Y4I1 | Q9Y4I1 | MYO5A_HUMAN | Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myosin-12) (Myoxin) | MYO5A | actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; cellular response to insulin stimulus [GO:0032869]; melanosome transport [GO:0032402]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; vesicle transport along actin filament [GO:0030050]; vesicle-mediated transport [GO:0016192] | actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium tip [GO:0032433]; growth cone [GO:0030426]; insulin-responsive compartment [GO:0032593]; melanosome [GO:0042470]; membrane [GO:0016020]; myosin complex [GO:0016459]; neuron projection [GO:0043005]; ruffle [GO:0001726] | actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267] | 9719.688100643785 | -0.35832110507251 | 9.98392138490255E-4 | 0.00683199258053838 |
| Q96LJ7 | Q96LJ7 | DHRS1_HUMAN | Dehydrogenase/reductase SDR family member 1 (EC 1.1.1.-) (Short chain dehydrogenase/reductase family 19C member 1) (Protein SDR19C1) | DHRS1 | endoplasmic reticulum [GO:0005783] | carbonyl reductase (NADPH) activity [GO:0004090]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; testosterone 17-beta-dehydrogenase (NADP+) activity [GO:0047045] | 13327.87882162655 | -0.825337274766089 | 0.00101287456536139 | 0.00692273496663163 | |
| Q9Y2J4 | Q9Y2J4 | AMOL2_HUMAN | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | AMOTL2 | actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; establishment of cell polarity involved in ameboidal cell migration [GO:0003365]; hippo signaling [GO:0035329]; regulation of cell migration [GO:0030334]; Wnt signaling pathway [GO:0016055] | bicellular tight junction [GO:0005923]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] | 3384.84523469952 | -1.19761620540463 | 0.00102030451769702 | 0.00696511493647144 | |
| Q6EEV4 | Q6EEV4 | GL1AD_HUMAN | DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5 (DNA-directed RNA polymerase II subunit M, isoforms 4/5) | POLR2M | 20628.444720792002 | -0.562799901915498 | 0.00103007539352148 | 0.00702335400685045 | |||
| Q9NRX5 | Q9NRX5 | SERC1_HUMAN | Serine incorporator 1 (Tumor differentially expressed protein 1-like) (Tumor differentially expressed protein 2) | SERINC1 | membrane biogenesis [GO:0044091]; phosphatidylserine metabolic process [GO:0006658]; phospholipid biosynthetic process [GO:0008654]; positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity [GO:1904219]; positive regulation of serine C-palmitoyltransferase activity [GO:1904222]; sphingolipid metabolic process [GO:0006665] | endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] | protein-macromolecule adaptor activity [GO:0030674] | 35847.4198624234 | -0.435398257820472 | 0.00103416024835387 | 0.00704273072977529 |
| P49189 | P49189 | AL9A1_HUMAN | 4-trimethylaminobutyraldehyde dehydrogenase (TMABA-DH) (TMABALDH) (EC 1.2.1.47) (Aldehyde dehydrogenase E3 isozyme) (Aldehyde dehydrogenase family 9 member A1) (EC 1.2.1.3) (Formaldehyde dehydrogenase) (EC 1.2.1.46) (Gamma-aminobutyraldehyde dehydrogenase) (EC 1.2.1.19) (R-aminobutyraldehyde dehydrogenase) [Cleaved into: 4-trimethylaminobutyraldehyde dehydrogenase, N-terminally processed] | ALDH9A1 | carnitine biosynthetic process [GO:0045329]; cellular aldehyde metabolic process [GO:0006081]; protein homotetramerization [GO:0051289] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] | 1-pyrroline dehydrogenase activity [GO:0033737]; 4-trimethylammoniobutyraldehyde dehydrogenase activity [GO:0047105]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aminobutyraldehyde dehydrogenase activity [GO:0019145]; betaine-aldehyde dehydrogenase activity [GO:0008802]; formaldehyde dehydrogenase activity [GO:0018467]; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity [GO:0043878]; small molecule binding [GO:0036094] | 41736.53132991685 | -0.187070971178434 | 0.00104883282966777 | 0.00712552375647196 |
| O43524 | O43524 | FOXO3_HUMAN | Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) | FOXO3 | antral ovarian follicle growth [GO:0001547]; brain morphogenesis [GO:0048854]; canonical Wnt signaling pathway [GO:0060070]; cellular response to amyloid-beta [GO:1904646]; cellular response to corticosterone stimulus [GO:0071386]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to hypoxia [GO:0071456]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to oxidative stress [GO:0034599]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; initiation of primordial ovarian follicle growth [GO:0001544]; mitochondrial transcription [GO:0006390]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell migration [GO:0030336]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuronal stem cell population maintenance [GO:0097150]; oocyte maturation [GO:0001556]; ovulation from ovarian follicle [GO:0001542]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of hydrogen peroxide-mediated programmed cell death [GO:1901300]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of muscle atrophy [GO:0014737]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of translation [GO:0006417]; response to dexamethasone [GO:0071548]; response to fatty acid [GO:0070542]; response to starvation [GO:0042594]; response to water-immersion restraint stress [GO:1990785]; response to xenobiotic stimulus [GO:0009410]; tumor necrosis factor-mediated signaling pathway [GO:0033209] | chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription repressor complex [GO:0090571] | beta-catenin binding [GO:0008013]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; mitochondrial transcription factor activity [GO:0034246]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221] | 4599.797366620054 | 0.390816952577473 | 0.00104872549913725 | 0.00712552375647196 |
| P47756 | P47756 | CAPZB_HUMAN | F-actin-capping protein subunit beta (CapZ beta) | CAPZB | actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; cell morphogenesis [GO:0000902]; cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032]; negative regulation of filopodium assembly [GO:0051490]; regulation of cell morphogenesis [GO:0022604]; regulation of lamellipodium assembly [GO:0010591] | actin cytoskeleton [GO:0015629]; brush border [GO:0005903]; cortical cytoskeleton [GO:0030863]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; F-actin capping protein complex [GO:0008290]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lamellipodium [GO:0030027]; membrane [GO:0016020]; postsynaptic density [GO:0014069]; sarcomere [GO:0030017]; Schaffer collateral - CA1 synapse [GO:0098685]; sperm connecting piece [GO:0097224]; WASH complex [GO:0071203] | actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296] | 216316.8093731125 | 0.165887310017454 | 0.00105331569835438 | 0.00713885974506691 |
| Q69YQ0 | Q69YQ0 | CYTSA_HUMAN | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | SPECC1L | actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell division [GO:0051301] | actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; filamentous actin [GO:0031941]; gap junction [GO:0005921]; microtubule organizing center [GO:0005815]; spindle [GO:0005819] | 15533.458739914298 | -0.241504746213062 | 0.00105286547576712 | 0.00713885974506691 | |
| Q9Y2E5 | Q9Y2E5 | MA2B2_HUMAN | Epididymis-specific alpha-mannosidase (EC 3.2.1.24) (Alpha-1,6-mannosidase) (Mannosidase alpha class 2B member 2) | MAN2B2 | mannose metabolic process [GO:0006013]; oligosaccharide catabolic process [GO:0009313] | extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764] | alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] | 15371.52609241915 | 0.310931942007149 | 0.00106761669446531 | 0.00722714001295152 |
| P06865 | P06865 | HEXA_HUMAN | Beta-hexosaminidase subunit alpha (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit alpha) (Hexosaminidase subunit A) (N-acetyl-beta-glucosaminidase subunit alpha) | HEXA | adult walking behavior [GO:0007628]; carbohydrate metabolic process [GO:0005975]; cell morphogenesis involved in neuron differentiation [GO:0048667]; dermatan sulfate catabolic process [GO:0030209]; ganglioside catabolic process [GO:0006689]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan metabolic process [GO:0030203]; hyaluronan catabolic process [GO:0030214]; lipid storage [GO:0019915]; lysosome organization [GO:0007040]; maintenance of location in cell [GO:0051651]; myelination [GO:0042552]; neuromuscular process controlling balance [GO:0050885]; neuromuscular process controlling posture [GO:0050884]; sensory perception of sound [GO:0007605]; sexual reproduction [GO:0019953]; skeletal system development [GO:0001501] | azurophil granule [GO:0042582]; beta-N-acetylhexosaminidase complex [GO:1905379]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020] | acetylglucosaminyltransferase activity [GO:0008375]; beta-N-acetylhexosaminidase activity [GO:0004563]; N-acetyl-beta-D-galactosaminidase activity [GO:0102148]; protein heterodimerization activity [GO:0046982] | 45785.12829604085 | 0.130203440429527 | 0.00108182483458726 | 0.00731458175748379 |
| P20338 | P20338 | RAB4A_HUMAN | Ras-related protein Rab-4A (EC 3.6.5.2) | RAB4A | antigen processing and presentation [GO:0019882]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; regulation of endocytosis [GO:0030100]; vesicle-mediated transport [GO:0016192] | cytoplasmic vesicle membrane [GO:0030659]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; insulin-responsive compartment [GO:0032593]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic recycling endosome [GO:0098837]; recycling endosome membrane [GO:0055038]; vesicle [GO:0031982] | G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] | 21894.94273304135 | -0.487350758662822 | 0.00109645683149328 | 0.00740467748181276 |
| P62979 | P62979 | RS27A_HUMAN | Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)] | RPS27A | cytoplasmic translation [GO:0002181]; modification-dependent protein catabolic process [GO:0019941]; protein ubiquitination [GO:0016567]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; small-subunit processome [GO:0032040]; synapse [GO:0045202]; vesicle [GO:0031982] | metal ion binding [GO:0046872]; protein tag activity [GO:0031386]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin protein ligase binding [GO:0031625] | 764457.9132184784 | 0.308241657099386 | 0.00111043391883455 | 0.00749014117156733 |
| Q9UKI2 | Q9UKI2 | BORG2_HUMAN | Cdc42 effector protein 3 (Binder of Rho GTPases 2) (MSE55-related Cdc42-binding protein) | CDC42EP3 | positive regulation of actin filament polymerization [GO:0030838]; positive regulation of pseudopodium assembly [GO:0031274]; regulation of cell shape [GO:0008360]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165] | actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; plasma membrane [GO:0005886] | cytoskeletal regulatory protein binding [GO:0005519]; small GTPase binding [GO:0031267] | 15034.11859414055 | -0.367647234382342 | 0.00113671250447463 | 0.00764011038001575 |
| Q92696 | Q92696 | PGTA_HUMAN | Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit alpha) (Rab geranyl-geranyltransferase subunit alpha) (Rab GG transferase alpha) (Rab GGTase alpha) (Rab geranylgeranyltransferase subunit alpha) | RABGGTA | protein geranylgeranylation [GO:0018344]; protein modification process [GO:0036211]; visual perception [GO:0007601] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; Rab-protein geranylgeranyltransferase complex [GO:0005968] | Rab geranylgeranyltransferase activity [GO:0004663]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270] | 26076.97164747575 | -0.300859691088422 | 0.00113599235420169 | 0.00764011038001575 |
| P10599 | P10599 | THIO_HUMAN | Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP) (allergen Hom s Trx) | TXN | activation of protein kinase B activity [GO:0032148]; cell redox homeostasis [GO:0045454]; cellular detoxification of hydrogen peroxide [GO:0061692]; negative regulation of protein export from nucleus [GO:0046826]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA binding [GO:0043388]; positive regulation of peptidyl-cysteine S-nitrosylation [GO:2000170]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; response to nitric oxide [GO:0071731]; response to radiation [GO:0009314] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | protein homodimerization activity [GO:0042803]; protein-disulfide reductase (NAD(P)) activity [GO:0047134]; protein-disulfide reductase activity [GO:0015035]; RNA binding [GO:0003723]; thioredoxin-disulfide reductase (NADP) activity [GO:0004791] | 253689.624766758 | 0.572590263119282 | 0.00113450810552064 | 0.00764011038001575 |
| Q96L92 | Q96L92 | SNX27_HUMAN | Sorting nexin-27 | SNX27 | endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; endosome to lysosome transport [GO:0008333]; establishment of natural killer cell polarity [GO:0001770]; intracellular protein transport [GO:0006886]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; signal transduction [GO:0007165] | cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; immunological synapse [GO:0001772]; intracellular membrane-bounded organelle [GO:0043231]; Schaffer collateral - CA1 synapse [GO:0098685] | phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3-phosphate binding [GO:0032266] | 18350.93816482485 | -0.336917010593344 | 0.00114255227129844 | 0.00767026204878785 |
| Q9H0A8 | Q9H0A8 | COMD4_HUMAN | COMM domain-containing protein 4 | COMMD4 | cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | 7164.24144971605 | -1.31454240912347 | 0.00116286519028841 | 0.00779738954813506 | ||
| P30046 | P30046 | DOPD_HUMAN | D-dopachrome decarboxylase (EC 4.1.1.84) (D-dopachrome tautomerase) (Phenylpyruvate tautomerase II) | DDT | melanin biosynthetic process [GO:0042438]; negative regulation of macrophage chemotaxis [GO:0010760]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of inflammatory response [GO:0050729]; positive regulation of tumor necrosis factor production [GO:0032760] | cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615] | cytokine receptor binding [GO:0005126]; D-dopachrome decarboxylase activity [GO:0033981]; dopachrome isomerase activity [GO:0004167]; phenylpyruvate tautomerase activity [GO:0050178] | 36128.6064247612 | -0.439158956379521 | 0.00117091315744443 | 0.00784207322704505 |
| Q9BXB5 | Q9BXB5 | OSB10_HUMAN | Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10) | OSBPL10 | phosphatidylserine acyl-chain remodeling [GO:0036150] | cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] | cholesterol binding [GO:0015485]; phosphatidylserine binding [GO:0001786]; phospholipid transporter activity [GO:0005548]; sterol transporter activity [GO:0015248] | 4290.92465981446 | -1.66055173574488 | 0.00117253630138948 | 0.00784367258993244 |
| P60059 | P60059 | SC61G_HUMAN | Protein transport protein Sec61 subunit gamma | SEC61G | post-translational protein targeting to membrane, translocation [GO:0031204]; protein targeting to ER [GO:0045047] | cytosol [GO:0005829]; membrane [GO:0016020]; Ssh1 translocon complex [GO:0071261] | protein transmembrane transporter activity [GO:0008320]; ribosome binding [GO:0043022] | 52008.9145239626 | -1.27114319651003 | 0.00119419063241287 | 0.00797910863590955 |
| Q9UK41 | Q9UK41 | VPS28_HUMAN | Vacuolar protein sorting-associated protein 28 homolog (H-Vps28) (ESCRT-I complex subunit VPS28) | VPS28 | macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of ubiquitin-dependent endocytosis [GO:2000397]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding via host ESCRT complex [GO:0039702] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886] | protein-containing complex binding [GO:0044877]; ubiquitin binding [GO:0043130] | 9306.12193803556 | 0.324373229492285 | 0.00120983231315435 | 0.00807409880604543 |
| O75694 | O75694 | NU155_HUMAN | Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155) | NUP155 | atrial cardiac muscle cell action potential [GO:0086014]; miRNA processing [GO:0035196]; mRNA export from nucleus [GO:0006406]; nuclear envelope organization [GO:0006998]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606]; protein localization to nuclear inner membrane [GO:0036228]; RNA export from nucleus [GO:0006405]; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000972] | cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore inner ring [GO:0044611] | structural constituent of nuclear pore [GO:0017056] | 7675.696317086905 | -0.343724031147288 | 0.0012181991808585 | 0.00812037242205208 |
| O75947 | O75947 | ATP5H_HUMAN | ATP synthase subunit d, mitochondrial (ATPase subunit d) (ATP synthase peripheral stalk subunit d) | ATP5PD | proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776] | mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase, stator stalk [GO:0000274]; mitochondrion [GO:0005739] | proton-transporting ATP synthase activity, rotational mechanism [GO:0046933] | 80561.94680398825 | -0.215766581192262 | 0.00125029312790214 | 0.0083245133521663 |
| Q9Y6K9 | Q9Y6K9 | NEMO_HUMAN | NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) | IKBKG | anoikis [GO:0043276]; apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; defense response to bacterium [GO:0042742]; DNA damage response [GO:0006974]; establishment of vesicle localization [GO:0051650]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of macroautophagy [GO:0016239]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of T cell receptor signaling pathway [GO:0050862]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein-containing complex assembly [GO:0065003]; response to virus [GO:0009615]; T cell receptor signaling pathway [GO:0050852] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; IkappaB kinase complex [GO:0008385]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle pole [GO:0000922]; ubiquitin ligase complex [GO:0000151] | identical protein binding [GO:0042802]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; linear polyubiquitin binding [GO:1990450]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; signaling adaptor activity [GO:0035591]; transferrin receptor binding [GO:1990459]; ubiquitin protein ligase binding [GO:0031625] | 13363.94425547375 | 0.203532211101292 | 0.00128176197314116 | 0.00851402501737142 |
| O75438 | O75438 | NDUB1_HUMAN | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (Complex I-MNLL) (CI-MNLL) (NADH-ubiquinone oxidoreductase MNLL subunit) | NDUFB1 | aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776] | mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607] | NADH dehydrogenase (ubiquinone) activity [GO:0008137] | 7962.30562601213 | -1.66231868980122 | 0.00128113866009568 | 0.00851402501737142 |
| Q15477 | Q15477 | SKI2_HUMAN | Superkiller complex protein 2 (Ski2) (EC 3.6.4.13) (Helicase-like protein) (HLP) | SKIC2 | nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [GO:0070478]; rescue of stalled ribosome [GO:0072344] | cytosol [GO:0005829]; nucleus [GO:0005634]; Ski complex [GO:0055087] | 3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] | 8900.30700154804 | -0.375974062043383 | 0.00128972262773389 | 0.00854686363595345 |
| Q9UIA9 | Q9UIA9 | XPO7_HUMAN | Exportin-7 (Exp7) (Ran-binding protein 16) | XPO7 | protein export from nucleus [GO:0006611] | cytoplasm [GO:0005737]; nuclear pore [GO:0005643]; nucleus [GO:0005634] | nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267] | 9969.884664973595 | -0.35692625332021 | 0.0012893140331076 | 0.00854686363595345 |
| Q9P0J0 | Q9P0J0 | NDUAD_HUMAN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (Cell death regulatory protein GRIM-19) (Complex I-B16.6) (CI-B16.6) (Gene associated with retinoic and interferon-induced mortality 19 protein) (GRIM-19) (Gene associated with retinoic and IFN-induced mortality 19 protein) (NADH-ubiquinone oxidoreductase B16.6 subunit) | NDUFA13 | aerobic respiration [GO:0009060]; apoptotic signaling pathway [GO:0097190]; cellular response to interferon-beta [GO:0035458]; cellular response to retinoic acid [GO:0071300]; extrinsic apoptotic signaling pathway [GO:0097191]; mitochondrial respiratory chain complex I assembly [GO:0032981]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of protein catabolic process [GO:0045732]; protein insertion into mitochondrial inner membrane [GO:0045039]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; reactive oxygen species metabolic process [GO:0072593] | cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respirasome [GO:0005746]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] | ATP binding [GO:0005524]; endopeptidase activator activity [GO:0061133] | 12731.027562449199 | -1.67100920262084 | 0.00130443283427079 | 0.00863424817637649 |
| Q9P000 | Q9P000 | COMD9_HUMAN | COMM domain-containing protein 9 | COMMD9 | cholesterol homeostasis [GO:0042632]; sodium ion transport [GO:0006814] | cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; secretory granule lumen [GO:0034774] | 4280.2047239697 | -1.03622881395651 | 0.00132028937496254 | 0.00872900769957728 | |
| P22059 | P22059 | OSBP1_HUMAN | Oxysterol-binding protein 1 | OSBP | bile acid biosynthetic process [GO:0006699]; ceramide transport [GO:0035627]; intracellular cholesterol transport [GO:0032367]; phospholipid transport [GO:0015914]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of secretory granule organization [GO:1904411]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; sphingomyelin biosynthetic process [GO:0006686]; sterol transport [GO:0015918] | cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perinuclear endoplasmic reticulum [GO:0097038]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] | oxysterol binding [GO:0008142]; phosphatidylinositol-4-phosphate binding [GO:0070273]; protein domain specific binding [GO:0019904]; sterol binding [GO:0032934]; sterol transfer activity [GO:0120015]; sterol transporter activity [GO:0015248] | 26261.14533466645 | -0.148178848170832 | 0.00132633779853614 | 0.00875877618473866 |
| Q05209 | Q05209 | PTN12_HUMAN | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | PTPN12 | cellular response to epidermal growth factor stimulus [GO:0071364]; negative regulation of ERBB signaling pathway [GO:1901185]; negative regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000587]; peptidyl-tyrosine dephosphorylation [GO:0035335]; protein dephosphorylation [GO:0006470]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; tissue regeneration [GO:0042246] | cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; podosome [GO:0002102] | non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity [GO:0004725]; SH3 domain binding [GO:0017124] | 14738.3916310521 | 0.169395629682187 | 0.00133508394342085 | 0.00880626964309957 |
| Q9Y3D8 | Q9Y3D8 | KAD6_HUMAN | Adenylate kinase isoenzyme 6 (AK6) (EC 2.7.4.3) (Adrenal gland protein AD-004) (Coilin-interacting nuclear ATPase protein) (hCINAP) (Dual activity adenylate kinase/ATPase) (AK/ATPase) | AK6 | nucleobase-containing small molecule interconversion [GO:0015949]; phosphorylation [GO:0016310]; rRNA processing [GO:0006364] | Cajal body [GO:0015030]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleoside monophosphate kinase activity [GO:0050145] | 8714.36802941849 | 0.646181114543721 | 0.00134196189646942 | 0.00884134430859966 |
| P41217 | P41217 | OX2G_HUMAN | OX-2 membrane glycoprotein (CD antigen CD200) | CD200 | cell-cell adhesion [GO:0098609]; heterotypic cell-cell adhesion [GO:0034113]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of leukocyte activation [GO:0002695]; negative regulation of macrophage activation [GO:0043031]; negative regulation of macrophage migration [GO:1905522]; negative regulation of matrix metallopeptidase secretion [GO:1904465]; negative regulation of neuroinflammatory response [GO:0150079]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of T cell migration [GO:2000405]; positive regulation of arginase activity [GO:0150072]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of protein-glutamine gamma-glutamyltransferase activity [GO:0150074]; positive regulation of transforming growth factor beta production [GO:0071636]; regulation of immune response [GO:0050776]; regulation of neuroinflammatory response [GO:0150077] | axon [GO:0030424]; cell body [GO:0044297]; cell surface [GO:0009986]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] | cell-cell adhesion mediator activity [GO:0098632]; glycosylated region protein binding [GO:0140081]; protein binding involved in heterotypic cell-cell adhesion [GO:0086080] | 26828.299145845398 | 0.78785179768486 | 0.00134759456124936 | 0.00886663338061304 |
| Q9UNW1 | Q9UNW1 | MINP1_HUMAN | Multiple inositol polyphosphate phosphatase 1 (EC 3.1.3.62) (2,3-bisphosphoglycerate 3-phosphatase) (2,3-BPG phosphatase) (EC 3.1.3.80) | MINPP1 | bone mineralization [GO:0030282]; inositol phosphate metabolic process [GO:0043647]; intracellular monoatomic cation homeostasis [GO:0030003]; ossification [GO:0001503] | endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] | 3-phytase activity [GO:0016158]; 4-phytase activity [GO:0008707]; acid phosphatase activity [GO:0003993]; bisphosphoglycerate 3-phosphatase activity [GO:0034417]; inositol bisphosphate phosphatase activity [GO:0016312]; inositol hexakisphosphate 2-phosphatase activity [GO:0052826]; inositol pentakisphosphate phosphatase activity [GO:0052827]; inositol phosphate phosphatase activity [GO:0052745]; inositol trisphosphate phosphatase activity [GO:0046030]; inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity [GO:0030351]; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [GO:0051717]; inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity [GO:0030352]; inositol-hexakisphosphate phosphatase activity [GO:0004446] | 20239.34803379195 | 0.296209139430928 | 0.00134893010485147 | 0.00886663338061304 |
| O00418 | O00418 | EF2K_HUMAN | Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) | EEF2K | cellular response to anoxia [GO:0071454]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to calcium ion [GO:0071277]; cellular response to cAMP [GO:0071320]; cellular response to insulin stimulus [GO:0032869]; myosin II filament disassembly [GO:0031037]; negative regulation of apoptotic process [GO:0043066]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of endocytosis [GO:0045807]; positive regulation of synapse assembly [GO:0051965]; protein autophosphorylation [GO:0046777]; regulation of protein autophosphorylation [GO:0031952]; regulation of translation at postsynapse [GO:0140245]; response to differentiation-inducing factor 1 [GO:1903013]; response to ischemia [GO:0002931]; response to prolactin [GO:1990637]; translational elongation [GO:0006414] | actomyosin contractile ring [GO:0005826]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069] | ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; elongation factor-2 kinase activity [GO:0004686]; myosin heavy chain kinase activity [GO:0016905]; protein kinase activity [GO:0004672]; translation factor activity, RNA binding [GO:0008135] | 8152.287606835811 | -0.630438108830596 | 0.00135722872657315 | 0.00891084352811526 |
| Q99424 | Q99424 | ACOX2_HUMAN | Peroxisomal acyl-coenzyme A oxidase 2 (EC 1.17.99.3) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase) (Trihydroxycoprostanoyl-CoA oxidase) (THCA-CoA oxidase) (THCCox) | ACOX2 | bile acid biosynthetic process [GO:0006699]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; lipid homeostasis [GO:0055088]; very long-chain fatty acid metabolic process [GO:0000038] | cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity [GO:0033791]; FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; flavin adenine dinucleotide binding [GO:0050660]; palmitoyl-CoA oxidase activity [GO:0016401]; protein homodimerization activity [GO:0042803] | 8455.544362628765 | -0.519068138126722 | 0.0013789217542589 | 0.0090323360226947 |
| P49792 | P49792 | RBP2_HUMAN | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | RANBP2 | centrosome localization [GO:0051642]; mRNA transport [GO:0051028]; NLS-bearing protein import into nucleus [GO:0006607]; nuclear export [GO:0051168]; nucleocytoplasmic transport [GO:0006913]; protein folding [GO:0006457]; protein sumoylation [GO:0016925]; regulation of gluconeogenesis [GO:0006111]; response to amphetamine [GO:0001975] | annulate lamellae [GO:0005642]; cytoplasm [GO:0005737]; cytoplasmic periphery of the nuclear pore complex [GO:1990723]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inclusion body [GO:0042405]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore cytoplasmic filaments [GO:0044614]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; SUMO ligase complex [GO:0106068] | GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789] | 7518.6648188222 | -0.479401157658033 | 0.00138472624305372 | 0.00905988324843228 |
| Q00610 | Q00610 | CLH1_HUMAN | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | CLTC | amyloid-beta clearance by transcytosis [GO:0150093]; autophagy [GO:0006914]; cell division [GO:0051301]; clathrin coat assembly [GO:0048268]; clathrin coat disassembly [GO:0072318]; clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886]; mitotic cell cycle [GO:0000278]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; negative regulation of protein localization to plasma membrane [GO:1903077]; osteoblast differentiation [GO:0001649]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of mitotic spindle organization [GO:0060236]; retrograde transport, endosome to Golgi [GO:0042147]; transferrin transport [GO:0033572] | clathrin coat [GO:0030118]; clathrin coat of coated pit [GO:0030132]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin complex [GO:0071439]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; focal adhesion [GO:0005925]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane [GO:0016020]; mitotic spindle [GO:0072686]; mitotic spindle microtubule [GO:1990498]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; trans-Golgi network membrane [GO:0032588] | clathrin light chain binding [GO:0032051]; disordered domain specific binding [GO:0097718]; double-stranded RNA binding [GO:0003725]; low-density lipoprotein particle receptor binding [GO:0050750]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]; ubiquitin-specific protease binding [GO:1990381] | 98432.30341969154 | -0.302318721138449 | 0.00140843789982765 | 0.00920439347223007 |
| Q16739 | Q16739 | CEGT_HUMAN | Ceramide glucosyltransferase (EC 2.4.1.80) (GLCT-1) (Glucosylceramide synthase) (GCS) (Glycosylceramide synthase) (UDP-glucose ceramide glucosyltransferase) (UDP-glucose:N-acylsphingosine D-glucosyltransferase) | UGCG | cell differentiation [GO:0030154]; cornified envelope assembly [GO:1903575]; epidermis development [GO:0008544]; establishment of skin barrier [GO:0061436]; glucosylceramide biosynthetic process [GO:0006679]; glycosphingolipid biosynthetic process [GO:0006688]; intestinal lipid absorption [GO:0098856]; keratinocyte differentiation [GO:0030216]; leptin-mediated signaling pathway [GO:0033210]; neuron development [GO:0048666]; protein lipidation [GO:0006497]; regulation of signal transduction [GO:0009966] | Golgi membrane [GO:0000139]; membrane [GO:0016020] | ceramide glucosyltransferase activity [GO:0008120]; dihydroceramide glucosyltransferase activity [GO:0102769] | 7862.608214054275 | -1.24729244469462 | 0.00141797402132937 | 0.00925603779360857 |
| Q9UBI6 | Q9UBI6 | GBG12_HUMAN | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 | GNG12 | G protein-coupled receptor signaling pathway [GO:0007186]; signal transduction [GO:0007165] | extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886] | G-protein beta-subunit binding [GO:0031681]; PDZ domain binding [GO:0030165] | 73193.09661394125 | -1.2680305727279 | 0.00144016843445664 | 0.0093900970651684 |
| Q9NSY1 | Q9NSY1 | BMP2K_HUMAN | BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) | BMP2K | phosphorylation [GO:0016310]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of bone mineralization [GO:0030500]; regulation of clathrin-dependent endocytosis [GO:2000369] | cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634] | AP-2 adaptor complex binding [GO:0035612]; ATP binding [GO:0005524]; phosphatase regulator activity [GO:0019208]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | 11197.734844409799 | 0.673285551768948 | 0.00144349112216742 | 0.00940094333126506 |
| Q96FV2 | Q96FV2 | SCRN2_HUMAN | Secernin-2 | SCRN2 | proteolysis [GO:0006508] | extracellular exosome [GO:0070062] | cysteine-type exopeptidase activity [GO:0070004]; dipeptidase activity [GO:0016805] | 12046.297087757499 | -0.247403908270342 | 0.00146832470457224 | 0.00954074286250721 |
| Q8TF66 | Q8TF66 | LRC15_HUMAN | Leucine-rich repeat-containing protein 15 (Leucine-rich repeat protein induced by beta-amyloid homolog) (hLib) | LRRC15 | negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of cell migration [GO:0030335]; receptor-mediated virion attachment to host cell [GO:0046813] | apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] | collagen binding [GO:0005518]; fibronectin binding [GO:0001968]; laminin binding [GO:0043236]; protein sequestering activity [GO:0140311] | 2279.352414797225 | -4.5539130400248 | 0.00147018648041439 | 0.00954189759224279 |
| Q8NHG7 | Q8NHG7 | SVIP_HUMAN | Small VCP/p97-interacting protein | SVIP | negative regulation of ERAD pathway [GO:1904293]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly [GO:1904240]; positive regulation of autophagy [GO:0010508]; positive regulation of protein lipidation [GO:1903061] | endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; smooth endoplasmic reticulum membrane [GO:0030868]; tertiary granule membrane [GO:0070821] | ATPase binding [GO:0051117]; protein self-association [GO:0043621] | 22588.624561847202 | 0.633618421735817 | 0.00149372314101648 | 0.00968356443592609 |
| Q9BTY2 | Q9BTY2 | FUCO2_HUMAN | Plasma alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase 2) (Alpha-L-fucosidase 2) | FUCA2 | fucose metabolic process [GO:0006004]; glycoside catabolic process [GO:0016139]; regulation of entry of bacterium into host cell [GO:2000535]; response to bacterium [GO:0009617] | azurophil granule lumen [GO:0035578]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764] | alpha-L-fucosidase activity [GO:0004560] | 18973.5376897708 | 0.225250427382327 | 0.00149732409620555 | 0.00969581523325788 |
| Q13740 | Q13740 | CD166_HUMAN | CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166) | ALCAM | adaptive immune response [GO:0002250]; axon extension involved in axon guidance [GO:0048846]; cell adhesion [GO:0007155]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; motor neuron axon guidance [GO:0008045]; neuron projection extension [GO:1990138]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] | axon [GO:0030424]; dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] | identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102] | 51252.9569753146 | 0.334348620769633 | 0.00150079135684118 | 0.00969646968404413 |
| P68366 | P68366 | TBA4A_HUMAN | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | TUBA4A | microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278] | cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630] | GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; structural constituent of cytoskeleton [GO:0005200] | 38015.299073969654 | 0.298483005070956 | 0.00150084784908343 | 0.00969646968404413 |
| O14972 | O14972 | VP26C_HUMAN | Vacuolar protein sorting-associated protein 26C (Down syndrome critical region protein 3) (Down syndrome critical region protein A) | VPS26C | endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886] | endosome [GO:0005768]; nucleus [GO:0005634] | 3901.4710770571746 | -1.22795849000489 | 0.00153900507301113 | 0.00992036717142328 | |
| Q9Y230 | Q9Y230 | RUVB2_HUMAN | RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta) | RUVBL2 | box C/D snoRNP assembly [GO:0000492]; cellular response to estradiol stimulus [GO:0071392]; cellular response to UV [GO:0034644]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; establishment of protein localization to chromatin [GO:0071169]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; telomere maintenance [GO:0000723] | centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; euchromatin [GO:0000791]; extracellular exosome [GO:0070062]; Ino80 complex [GO:0031011]; membrane [GO:0016020]; MLL1 complex [GO:0071339]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; R2TP complex [GO:0097255]; ribonucleoprotein complex [GO:1990904]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]; Swr1 complex [GO:0000812] | ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase binding [GO:0051117]; beta-catenin binding [GO:0008013]; chromatin DNA binding [GO:0031490]; DNA helicase activity [GO:0003678]; identical protein binding [GO:0042802]; promoter-enhancer loop anchoring activity [GO:0140585]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; TBP-class protein binding [GO:0017025]; TFIID-class transcription factor complex binding [GO:0001094]; transcription corepressor activity [GO:0003714]; unfolded protein binding [GO:0051082] | 79914.88635596455 | 0.103835972518776 | 0.00155182302380442 | 0.00999162415099527 |
| Q9NX40 | Q9NX40 | OCAD1_HUMAN | OCIA domain-containing protein 1 (Ovarian cancer immunoreactive antigen domain containing 1) (Ovarian carcinoma immunoreactive antigen) | OCIAD1 | endocytosis [GO:0006897]; hematopoietic stem cell homeostasis [GO:0061484]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; regulation of stem cell differentiation [GO:2000736] | endosome [GO:0005768]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; membrane [GO:0016020] | 37450.876061322895 | 0.364649644289279 | 0.00155926065560105 | 0.0100281167703014 | |
| P22692 | P22692 | IBP4_HUMAN | Insulin-like growth factor-binding protein 4 (IBP-4) (IGF-binding protein 4) (IGFBP-4) | IGFBP4 | MAPK cascade [GO:0000165]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of MAPK cascade [GO:0043410]; regulation of cell growth [GO:0001558]; regulation of glucose metabolic process [GO:0010906]; regulation of insulin-like growth factor receptor signaling pathway [GO:0043567]; response to organic cyclic compound [GO:0014070]; signal transduction [GO:0007165]; type B pancreatic cell proliferation [GO:0044342] | endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] | insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]; signaling receptor binding [GO:0005102] | 3236.83256015305 | 2.97041426757149 | 0.00156171661426932 | 0.0100325241909863 |
| P30520 | P30520 | PURA2_HUMAN | Adenylosuccinate synthetase isozyme 2 (AMPSase 2) (AdSS 2) (EC 6.3.4.4) (Adenylosuccinate synthetase, acidic isozyme) (Adenylosuccinate synthetase, liver isozyme) (L-type adenylosuccinate synthetase) (IMP--aspartate ligase 2) | ADSS2 | 'de novo' AMP biosynthetic process [GO:0044208]; AMP biosynthetic process [GO:0006167]; aspartate metabolic process [GO:0006531]; cellular response to electrical stimulus [GO:0071257]; immune system process [GO:0002376]; IMP metabolic process [GO:0046040]; response to ammonium ion [GO:0060359]; response to purine-containing compound [GO:0014074] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739] | adenylosuccinate synthase activity [GO:0004019]; GTP binding [GO:0005525]; magnesium ion binding [GO:0000287]; phosphate ion binding [GO:0042301] | 42314.05435585465 | 0.160256772288689 | 0.00156925353442061 | 0.0100695249445381 |
| P10155 | P10155 | RO60_HUMAN | RNA-binding protein RO60 (60 kDa SS-A/Ro ribonucleoprotein) (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Ro60 autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) | RO60 | cellular response to interferon-alpha [GO:0035457]; cilium assembly [GO:0060271]; immune system development [GO:0002520]; regulation of gene expression [GO:0010468]; response to UV [GO:0009411]; smoothened signaling pathway [GO:0007224]; transcription by RNA polymerase III [GO:0006383] | cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904] | metal ion binding [GO:0046872]; RNA binding [GO:0003723]; U2 snRNA binding [GO:0030620] | 24867.480123795198 | -0.265365863596867 | 0.0015751900957131 | 0.0100961844822516 |
| Q9BRG1 | Q9BRG1 | VPS25_HUMAN | Vacuolar protein-sorting-associated protein 25 (hVps25) (Dermal papilla-derived protein 9) (ELL-associated protein of 20 kDa) (ESCRT-II complex subunit VPS25) | VPS25 | macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT II complex [GO:0000814]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | protein homodimerization activity [GO:0042803]; structural molecule activity [GO:0005198] | 9189.874658084555 | -0.768144867311703 | 0.0015850466091814 | 0.0101478803249964 |
| Q92520 | Q92520 | FAM3C_HUMAN | Protein FAM3C (Interleukin-like EMT inducer) | FAM3C | extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; platelet dense granule lumen [GO:0031089] | carbohydrate binding [GO:0030246]; cytokine activity [GO:0005125] | 68645.92012289815 | 0.329138271876877 | 0.0016009735213966 | 0.010238279878367 | |
| Q9H1A3 | Q9H1A3 | METL9_HUMAN | Protein-L-histidine N-pros-methyltransferase (EC 2.1.1.-) (DORA reverse strand protein) (DREV) (DREV1) (Methyltransferase-like protein 9) (hMETTL9) | METTL9 | methylation [GO:0032259] | endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739] | protein-L-histidine N-pros-methyltransferase activity [GO:0106370] | 9498.51450519944 | 0.408114822443185 | 0.001608051277176 | 0.0102719487446215 |
| Q86TI2 | Q86TI2 | DPP9_HUMAN | Dipeptidyl peptidase 9 (DP9) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 2) (DPRP-2) (Dipeptidyl peptidase IX) (DPP IX) (Dipeptidyl peptidase-like protein 9) (DPLP9) | DPP9 | negative regulation of programmed cell death [GO:0043069]; proteolysis [GO:0006508]; pyroptosis [GO:0070269] | cell leading edge [GO:0031252]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleus [GO:0005634] | aminopeptidase activity [GO:0004177]; dipeptidyl-peptidase activity [GO:0008239]; identical protein binding [GO:0042802]; serine-type peptidase activity [GO:0008236] | 11856.37012315025 | -0.381062112755854 | 0.00164617686948878 | 0.0104918314314099 |
| P11940 | P11940 | PABP1_HUMAN | Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) | PABPC1 | CRD-mediated mRNA stabilization [GO:0070934]; mRNA polyadenylation [GO:0006378]; mRNA splicing, via spliceosome [GO:0000398]; mRNA stabilization [GO:0048255]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of viral genome replication [GO:0045070]; regulatory ncRNA-mediated gene silencing [GO:0031047] | catalytic step 2 spliceosome [GO:0071013]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; mCRD-mediated mRNA stability complex [GO:0106002]; membrane [GO:0016020]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] | mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; translation activator activity [GO:0008494] | 132362.449560255 | 0.178298958827819 | 0.00165359181503888 | 0.0105272485663037 |
| Q9NP97 | Q9NP97 | DLRB1_HUMAN | Dynein light chain roadblock-type 1 (Bithoraxoid-like protein) (BLP) (Dynein light chain 2A, cytoplasmic) (Dynein-associated protein Km23) (Roadblock domain-containing protein 1) | DYNLRB1 | microtubule-based movement [GO:0007018]; visual behavior [GO:0007632] | centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; dynein complex [GO:0030286]; membrane [GO:0016020]; microtubule [GO:0005874] | dynein intermediate chain binding [GO:0045505]; microtubule motor activity [GO:0003777] | 18292.8377160889 | -0.710965269467645 | 0.00165603900166719 | 0.0105309954920834 |
| Q96S06 | Q96S06 | LMF1_HUMAN | Lipase maturation factor 1 (Transmembrane protein 112) | LMF1 | protein maturation [GO:0051604]; triglyceride metabolic process [GO:0006641] | endoplasmic reticulum membrane [GO:0005789] | 3825.085589586015 | -0.73299028982497 | 0.00165893212102497 | 0.0105375665893806 | |
| Q14696 | Q14696 | MESD_HUMAN | LRP chaperone MESD (LDLR chaperone MESD) (Mesoderm development LRP chaperone MESD) (Mesoderm development candidate 2) (Mesoderm development protein) (Renal carcinoma antigen NY-REN-61) | MESD | mesoderm development [GO:0007498]; ossification [GO:0001503]; phagocytosis [GO:0006909]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; protein folding [GO:0006457]; protein localization to cell surface [GO:0034394]; Wnt signaling pathway [GO:0016055] | endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] | identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750] | 93641.5804808861 | 0.402620989627649 | 0.00169216985566043 | 0.0107281420363264 |
| Q12792 | Q12792 | TWF1_HUMAN | Twinfilin-1 (Protein A6) (Protein tyrosine kinase 9) | TWF1 | actin filament depolymerization [GO:0030042]; barbed-end actin filament capping [GO:0051016]; negative regulation of actin filament polymerization [GO:0030837]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of neuron projection development [GO:0010976]; regulation of actin phosphorylation [GO:0043538]; regulation of lamellipodium assembly [GO:0010591]; sequestering of actin monomers [GO:0042989] | actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; myofibril [GO:0030016]; perinuclear region of cytoplasm [GO:0048471]; ruffle membrane [GO:0032587] | actin binding [GO:0003779]; actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546] | 49295.6439798289 | 0.285249231591059 | 0.00169272131670946 | 0.0107281420363264 |
| P12277 | P12277 | KCRB_HUMAN | Creatine kinase B-type (EC 2.7.3.2) (Brain creatine kinase) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase B-type) (CPK-B) | CKB | futile creatine cycle [GO:0140651]; phosphocreatine biosynthetic process [GO:0046314]; phosphorylation [GO:0016310]; substantia nigra development [GO:0021762] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] | ATP binding [GO:0005524]; creatine kinase activity [GO:0004111]; ubiquitin protein ligase binding [GO:0031625] | 9726.166256543405 | 0.329051211299533 | 0.00170270448309807 | 0.010779355979032 |
| Q9UHQ4 | Q9UHQ4 | BAP29_HUMAN | B-cell receptor-associated protein 29 (BCR-associated protein 29) (Bap29) | BCAP29 | apoptotic process [GO:0006915]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; osteoblast differentiation [GO:0001649]; protein localization to endoplasmic reticulum exit site [GO:0070973] | endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] | 32271.3271218258 | 0.290788451643283 | 0.00173633853754397 | 0.0109524556757985 | |
| Q15738 | Q15738 | NSDHL_HUMAN | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (EC 1.1.1.170) (Protein H105e3) | NSDHL | cholesterol biosynthetic process [GO:0006695]; cholesterol metabolic process [GO:0008203]; hair follicle development [GO:0001942]; labyrinthine layer blood vessel development [GO:0060716]; smoothened signaling pathway [GO:0007224] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811] | 3-beta-hydroxy-delta5-steroid dehydrogenase activity [GO:0003854]; 3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity [GO:0102175]; 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity [GO:0103066]; 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity [GO:0103067]; C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity [GO:0000252]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity [GO:0047012] | 21082.02231198745 | -0.216256147014526 | 0.00173971233819602 | 0.0109524556757985 |
| O95361 | O95361 | TRI16_HUMAN | Tripartite motif-containing protein 16 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM16) (Estrogen-responsive B box protein) | TRIM16 | positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of retinoic acid receptor signaling pathway [GO:0048386]; response to growth hormone [GO:0060416]; response to organophosphorus [GO:0046683]; response to retinoic acid [GO:0032526] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; PML body [GO:0016605] | DNA binding [GO:0003677]; interleukin-1 binding [GO:0019966]; NACHT domain binding [GO:0032089]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270] | 10416.36291211487 | -0.364513628757866 | 0.00173732497363516 | 0.0109524556757985 |
| Q969T9 | Q969T9 | WBP2_HUMAN | WW domain-binding protein 2 (WBP-2) | WBP2 | cellular response to estrogen stimulus [GO:0071391]; establishment of protein localization to chromatin [GO:0071169]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone receptor signaling pathway [GO:0050847]; response to estrogen [GO:0043627]; response to progesterone [GO:0032570]; transcription initiation-coupled chromatin remodeling [GO:0045815] | chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | chromatin DNA binding [GO:0031490]; nuclear estrogen receptor binding [GO:0030331]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713] | 48067.6385319165 | 0.304700598346627 | 0.00173848044047365 | 0.0109524556757985 |
| P53618 | P53618 | COPB_HUMAN | Coatomer subunit beta (Beta-coat protein) (Beta-COP) | COPB1 | endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886] | COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; ficolin-1-rich granule membrane [GO:0101003]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; tertiary granule membrane [GO:0070821]; transport vesicle [GO:0030133] | structural molecule activity [GO:0005198] | 63191.0319810822 | -0.216699428302539 | 0.00174300402868483 | 0.0109609998074676 |
| Q9Y333 | Q9Y333 | LSM2_HUMAN | U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5) | LSM2 | mRNA catabolic process [GO:0006402]; mRNA splicing, via spliceosome [GO:0000398]; spliceosomal tri-snRNP complex assembly [GO:0000244] | catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Lsm1-7-Pat1 complex [GO:1990726]; Lsm2-8 complex [GO:0120115]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; precatalytic spliceosome [GO:0071011]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688] | RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; U6 snRNA binding [GO:0017070] | 20390.7373455261 | -0.74880769203241 | 0.00174870006247241 | 0.0109846281086127 |
| O94919 | O94919 | ENDD1_HUMAN | Endonuclease domain-containing 1 protein (EC 3.1.30.-) | ENDOD1 | innate immune response [GO:0045087] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020] | endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676] | 8274.925559027435 | -0.709744227092668 | 0.0017604976701296 | 0.0110464892568708 |
| Q969X1 | Q969X1 | LFG3_HUMAN | Protein lifeguard 3 (Protein RECS1 homolog) (Transmembrane BAX inhibitor motif-containing protein 1) | TMBIM1 | negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of catalytic activity [GO:0043086]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of Fas signaling pathway [GO:1902045]; negative regulation of protein localization to plasma membrane [GO:1903077]; positive regulation of blood vessel remodeling [GO:2000504] | endoplasmic reticulum [GO:0005783]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] | death receptor binding [GO:0005123] | 18163.1252930212 | -1.85337625315407 | 0.00177398530587943 | 0.011118806131762 |
| C9J7I0 | C9J7I0 | UMAD1_HUMAN | UBAP1-MVB12-associated (UMA)-domain containing protein 1 (RPA3 antisense RNA 1) (RPA3 opposite strand) | UMAD1 | 11772.699774532699 | 0.597109705915688 | 0.00180128390979744 | 0.0112649830385346 | |||
| Q7Z4G1 | Q7Z4G1 | COMD6_HUMAN | COMM domain-containing protein 6 | COMMD6 | negative regulation of NF-kappaB transcription factor activity [GO:0032088] | cytoplasm [GO:0005737]; nucleus [GO:0005634] | NF-kappaB binding [GO:0051059] | 6823.31648568466 | -0.984370970633358 | 0.00181978341825385 | 0.0113681288289154 |
| Q14847 | Q14847 | LASP1_HUMAN | LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) | LASP1 | monoatomic ion transport [GO:0006811] | cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925] | actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; monoatomic ion transmembrane transporter activity [GO:0015075] | 852695.0965957965 | 0.330329289297234 | 0.00185933221276832 | 0.0116023968254904 |
| P00558 | P00558 | PGK1_HUMAN | Phosphoglycerate kinase 1 (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2) | PGK1 | canonical glycolysis [GO:0061621]; cellular response to hypoxia [GO:0071456]; epithelial cell differentiation [GO:0030855]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]; negative regulation of angiogenesis [GO:0016525]; phosphorylation [GO:0016310]; plasminogen activation [GO:0031639] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; membrane raft [GO:0045121] | ADP binding [GO:0043531]; ATP binding [GO:0005524]; phosphoglycerate kinase activity [GO:0004618]; protein-disulfide reductase (NAD(P)) activity [GO:0047134] | 423065.78904161253 | 0.160921275818825 | 0.00187514529906494 | 0.0116881994108932 |
| O15067 | O15067 | PUR4_HUMAN | Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotransferase) | PFAS | 'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; anterior head development [GO:0097065]; glutamine metabolic process [GO:0006541]; GMP biosynthetic process [GO:0006177]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; response to xenobiotic stimulus [GO:0009410] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] | ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphoribosylformylglycinamidine synthase activity [GO:0004642] | 8385.07964737339 | -0.354426853089798 | 0.00189479433848754 | 0.0117847472248852 |
| Q96EC8 | Q96EC8 | YIPF6_HUMAN | Protein YIPF6 (YIP1 family member 6) | YIPF6 | endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intestinal epithelial cell development [GO:0060576] | cis-Golgi network [GO:0005801]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138]; trans-Golgi network [GO:0005802] | identical protein binding [GO:0042802] | 13533.6681801251 | -1.41435528881645 | 0.00191429033171053 | 0.0118799222557195 |
| Q15942 | Q15942 | ZYX_HUMAN | Zyxin (Zyxin-2) | ZYX | cell-cell signaling [GO:0007267]; cell-matrix adhesion [GO:0007160]; cellular response to type II interferon [GO:0071346]; integrin-mediated signaling pathway [GO:0007229]; stress fiber assembly [GO:0043149]; transforming growth factor beta receptor signaling pathway [GO:0007179] | actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; stress fiber [GO:0001725] | metal ion binding [GO:0046872]; RNA binding [GO:0003723] | 152910.05602604698 | -0.214272206614391 | 0.00192012152533741 | 0.0119030728255599 |
| Q12974 | Q12974 | TP4A2_HUMAN | Protein tyrosine phosphatase type IVA 2 (EC 3.1.3.48) (HU-PP-1) (OV-1) (PTP(CAAXII)) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2) | PTP4A2 | dephosphorylation [GO:0016311] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | prenylated protein tyrosine phosphatase activity [GO:0004727]; protein tyrosine phosphatase activity [GO:0004725] | 16008.26654853735 | -0.356955696611833 | 0.00193967208663096 | 0.0120111279156842 |
| Q2PZI1 | Q2PZI1 | D19L1_HUMAN | Protein C-mannosyl-transferase DPY19L1 (EC 2.4.1.-) (Dpy-19-like protein 1) (Protein dpy-19 homolog 1) | DPY19L1 | protein glycosylation [GO:0006486] | endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637] | mannosyltransferase activity [GO:0000030] | 17445.3660470473 | -0.307163062943875 | 0.00197026494482306 | 0.0121872501936326 |
| Q86VX2 | Q86VX2 | COMD7_HUMAN | COMM domain-containing protein 7 | COMMD7 | negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; tumor necrosis factor-mediated signaling pathway [GO:0033209] | cytoplasmic vesicle [GO:0031410] | NF-kappaB binding [GO:0051059] | 11991.075223395601 | -0.533594120843637 | 0.00197329924766254 | 0.0121927083285234 |
| P05231 | P05231 | IL6_HUMAN | Interleukin-6 (IL-6) (B-cell stimulatory factor 2) (BSF-2) (CTL differentiation factor) (CDF) (Hybridoma growth factor) (Interferon beta-2) (IFN-beta-2) | IL6 | acute-phase response [GO:0006953]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; endocrine pancreas development [GO:0031018]; germinal center B cell differentiation [GO:0002314]; glucagon secretion [GO:0070091]; glucose homeostasis [GO:0042593]; hepatic immune response [GO:0002384]; hepatocyte proliferation [GO:0072574]; humoral immune response [GO:0006959]; inflammatory response [GO:0006954]; inflammatory response to wounding [GO:0090594]; interleukin-6-mediated signaling pathway [GO:0070102]; liver regeneration [GO:0097421]; maintenance of blood-brain barrier [GO:0035633]; monocyte chemotaxis [GO:0002548]; negative regulation of apoptotic process [GO:0043066]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chemokine production [GO:0032682]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of interleukin-1-mediated signaling pathway [GO:2000660]; negative regulation of lipid storage [GO:0010888]; negative regulation of neurogenesis [GO:0050768]; negative regulation of primary miRNA processing [GO:2000635]; neuron cellular homeostasis [GO:0070050]; neuron projection development [GO:0031175]; neutrophil apoptotic process [GO:0001781]; neutrophil mediated immunity [GO:0002446]; platelet activation [GO:0030168]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of apoptotic DNA fragmentation [GO:1902512]; positive regulation of apoptotic process [GO:0043065]; positive regulation of B cell activation [GO:0050871]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of gene expression [GO:0010628]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-21 production [GO:0032745]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of platelet aggregation [GO:1901731]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of receptor signaling pathway via STAT [GO:1904894]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type B pancreatic cell apoptotic process [GO:2000676]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of angiogenesis [GO:0045765]; regulation of astrocyte activation [GO:0061888]; regulation of glucagon secretion [GO:0070092]; regulation of insulin secretion [GO:0050796]; regulation of microglial cell activation [GO:1903978]; regulation of neuroinflammatory response [GO:0150077]; regulation of vascular endothelial growth factor production [GO:0010574]; response to activity [GO:0014823]; response to glucocorticoid [GO:0051384]; response to peptidoglycan [GO:0032494]; T follicular helper cell differentiation [GO:0061470]; T-helper 17 cell lineage commitment [GO:0072540]; vascular endothelial growth factor production [GO:0010573] | endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; interleukin-6 receptor complex [GO:0005896] | cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-6 receptor binding [GO:0005138] | 34104.9070218443 | 0.722193110638672 | 0.00198276109628402 | 0.0122245096534769 |
| Q9NX58 | Q9NX58 | LYAR_HUMAN | Cell growth-regulating nucleolar protein | LYAR | erythrocyte development [GO:0048821]; innate immune response [GO:0045087]; negative regulation of innate immune response [GO:0045824]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of phagocytosis [GO:0050766]; positive regulation of transcription by RNA polymerase I [GO:0045943]; rRNA processing [GO:0006364] | cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor outer segment [GO:0001750] | DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; transcription regulator inhibitor activity [GO:0140416] | 8338.250919913726 | 0.606410262461513 | 0.00200283623372865 | 0.012334858804681 |
| Q15126 | Q15126 | PMVK_HUMAN | Phosphomevalonate kinase (PMKase) (hPMK) (EC 2.7.4.2) | PMVK | cholesterol biosynthetic process [GO:0006695]; isopentenyl diphosphate biosynthetic process, mevalonate pathway [GO:0019287]; phosphorylation [GO:0016310]; response to cholesterol [GO:0070723]; sterol biosynthetic process [GO:0016126] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; peroxisome [GO:0005777] | ATP binding [GO:0005524]; phosphomevalonate kinase activity [GO:0004631] | 23912.318344579602 | -0.520250966450065 | 0.00202394560144295 | 0.0124513309204949 |
| Q9NYL2 | Q9NYL2 | M3K20_HUMAN | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) | MAP3K20 | cell death [GO:0008219]; cell differentiation [GO:0030154]; cellular response to gamma radiation [GO:0071480]; cellular response to UV-B [GO:0071493]; chromosome segregation [GO:0007059]; cytoskeleton organization [GO:0007010]; DNA damage checkpoint signaling [GO:0000077]; embryonic digit morphogenesis [GO:0042733]; GCN2-mediated signaling [GO:0140469]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; limb development [GO:0060173]; MAPK cascade [GO:0000165]; negative regulation of stress-activated protein kinase signaling cascade [GO:0070303]; negative regulation of translation in response to endoplasmic reticulum stress [GO:1902010]; p38MAPK cascade [GO:0038066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of mitotic DNA damage checkpoint [GO:1904291]; positive regulation of programmed cell death [GO:0043068]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; pyroptosis [GO:0070269]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; stress-activated MAPK cascade [GO:0051403]; stress-activated protein kinase signaling cascade [GO:0031098] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] | ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; magnesium ion binding [GO:0000287]; MAP kinase kinase kinase activity [GO:0004709]; protein kinase activator activity [GO:0030295]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; small ribosomal subunit rRNA binding [GO:0070181]; stalled ribosome sensor activity [GO:0170011] | 5144.94355609594 | -0.247764774331655 | 0.00202667062334925 | 0.0124545723990205 |
| O14618 | O14618 | CCS_HUMAN | Copper chaperone for superoxide dismutase (Superoxide dismutase copper chaperone) | CCS | cellular response to oxidative stress [GO:0034599]; protein maturation by copper ion transfer [GO:0015680]; removal of superoxide radicals [GO:0019430]; superoxide metabolic process [GO:0006801] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] | cadherin binding [GO:0045296]; copper ion binding [GO:0005507]; protein-disulfide reductase activity [GO:0015035]; superoxide dismutase copper chaperone activity [GO:0016532] | 32496.21265115405 | 0.302180635430868 | 0.00205257465927334 | 0.0126000953623432 |
| Q53TN4 | Q53TN4 | CYBR1_HUMAN | Plasma membrane ascorbate-dependent reductase CYBRD1 (EC 7.2.1.3) (Cytochrome b reductase 1) (Duodenal cytochrome b) (Ferric-chelate reductase 3) | CYBRD1 | ascorbate homeostasis [GO:0140576]; intracellular iron ion homeostasis [GO:0006879]; multicellular organismal-level iron ion homeostasis [GO:0060586]; reductive iron assimilation [GO:0033215]; response to iron ion [GO:0010039] | apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] | identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on metal ions [GO:0016722]; transmembrane ascorbate ferrireductase activity [GO:0140571]; transmembrane monodehydroascorbate reductase activity [GO:0140575] | 50945.0124278342 | -0.728928498163837 | 0.00205866630997567 | 0.0126238131085737 |
| P27658 | P27658 | CO8A1_HUMAN | Collagen alpha-1(VIII) chain (Endothelial collagen) [Cleaved into: Vastatin] | COL8A1 | angiogenesis [GO:0001525]; camera-type eye morphogenesis [GO:0048593]; cell adhesion [GO:0007155]; endodermal cell differentiation [GO:0035987]; endothelial cell proliferation [GO:0001935]; extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811] | collagen type VIII trimer [GO:0005591]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] | extracellular matrix structural constituent conferring tensile strength [GO:0030020] | 12110.560097954 | -0.458693357001249 | 0.00206441350710532 | 0.0126453696554149 |
| Q04323 | Q04323 | UBXN1_HUMAN | UBX domain-containing protein 1 (SAPK substrate protein 1) (UBA/UBX 33.3 kDa protein) | UBXN1 | negative regulation of ERAD pathway [GO:1904293]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein K48-linked deubiquitination [GO:1903094]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of ubiquitin-specific protease activity [GO:2000157]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098] | ATPase binding [GO:0051117]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; K6-linked polyubiquitin modification-dependent protein binding [GO:0071796]; polyubiquitin modification-dependent protein binding [GO:0031593]; proteasome regulatory particle binding [GO:1904855]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625] | 29851.5399131116 | 0.311922123888448 | 0.00208072372744313 | 0.0127315125698626 |
| Q9H910 | Q9H910 | JUPI2_HUMAN | Jupiter microtubule associated homolog 2 (Hematological and neurological expressed 1-like protein) (HN1-like protein) | JPT2 | endocytosis involved in viral entry into host cell [GO:0075509]; regulation of calcium-mediated signaling [GO:0050848] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | 129684.049214315 | 0.497246614890098 | 0.00209252276934103 | 0.0127898964520888 | |
| Q8NBN3 | Q8NBN3 | TM87A_HUMAN | Transmembrane protein 87A (Elkin1) | TMEM87A | cellular response to mechanical stimulus [GO:0071260]; retrograde transport, endosome to Golgi [GO:0042147] | cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; ruffle [GO:0001726] | 12110.006651301399 | 0.191270647808092 | 0.00210375881129656 | 0.012844717052593 | |
| O60711 | O60711 | LPXN_HUMAN | Leupaxin | LPXN | actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; endothelial cell migration [GO:0043542]; heart development [GO:0007507]; muscle structure development [GO:0061061]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of cell adhesion [GO:0007162]; protein-containing complex assembly [GO:0065003]; regulation of cell adhesion mediated by integrin [GO:0033628]; signal transduction [GO:0007165]; substrate adhesion-dependent cell spreading [GO:0034446]; transforming growth factor beta receptor signaling pathway [GO:0007179] | adherens junction [GO:0005912]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; filamentous actin [GO:0031941]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; podosome [GO:0002102]; stress fiber [GO:0001725]; Z disc [GO:0030018] | actin binding [GO:0003779]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; transcription coregulator activity [GO:0003712] | 11830.6988225407 | 0.587570082725434 | 0.00210741050985496 | 0.0128531624852941 |
| Q9Y2H0 | Q9Y2H0 | DLGP4_HUMAN | Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) | DLGAP4 | signaling [GO:0023052] | cholinergic synapse [GO:0098981]; glutamatergic synapse [GO:0098978]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; postsynaptic specialization [GO:0099572] | molecular adaptor activity [GO:0060090] | 19273.7175960928 | 0.291711860715027 | 0.00211367676400251 | 0.0128775188654175 |
| Q92819 | Q92819 | HYAS2_HUMAN | Hyaluronan synthase 2 (EC 2.4.1.212) (Hyaluronate synthase 2) (Hyaluronic acid synthase 2) (HA synthase 2) | HAS2 | atrioventricular canal development [GO:0036302]; bone morphogenesis [GO:0060349]; cellular response to fluid shear stress [GO:0071498]; cellular response to interleukin-1 [GO:0071347]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to tumor necrosis factor [GO:0071356]; endocardial cushion to mesenchymal transition [GO:0090500]; estrous cycle [GO:0044849]; extracellular matrix assembly [GO:0085029]; extracellular polysaccharide biosynthetic process [GO:0045226]; hyaluronan biosynthetic process [GO:0030213]; kidney development [GO:0001822]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of monocyte aggregation [GO:1900625]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of urine volume [GO:0035810]; regulation of extracellular matrix assembly [GO:1901201]; renal water absorption [GO:0070295]; vasculogenesis [GO:0001570] | cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum membrane [GO:0005789]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853] | hyaluronan synthase activity [GO:0050501]; identical protein binding [GO:0042802] | 13810.3741380421 | 0.648803136146645 | 0.00212887484611356 | 0.0129561813942851 |
| P15848 | P15848 | ARSB_HUMAN | Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) | ARSB | autophagy [GO:0006914]; colon epithelial cell migration [GO:0061580]; lysosomal transport [GO:0007041]; lysosome organization [GO:0007040]; positive regulation of neuron projection development [GO:0010976]; regulation of epithelial cell migration [GO:0010632]; response to estrogen [GO:0043627]; response to methylmercury [GO:0051597]; response to nutrient [GO:0007584]; response to pH [GO:0009268] | azurophil granule lumen [GO:0035578]; cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764] | arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]; N-acetylgalactosamine-4-sulfatase activity [GO:0003943] | 31587.92436441745 | -0.346113461647399 | 0.00213886421889745 | 0.0130030092964302 |
| Q5XKP0 | Q5XKP0 | MIC13_HUMAN | MICOS complex subunit MIC13 (Protein P117) | MICOS13 | cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007] | MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; SAM complex [GO:0001401] | 15645.763997159149 | -0.706865906198028 | 0.00216173833147896 | 0.01312798433672 | |
| O95864 | O95864 | FADS2_HUMAN | Acyl-CoA 6-desaturase (EC 1.14.19.3) (Delta(6) fatty acid desaturase) (D6D) (Delta(6) desaturase) (Delta-6 desaturase) (Fatty acid desaturase 2) | FADS2 | alpha-linolenic acid metabolic process [GO:0036109]; arachidonic acid metabolite production involved in inflammatory response [GO:0002538]; linoleic acid metabolic process [GO:0043651]; lipid metabolic process [GO:0006629]; positive regulation of cellular response to oxidative stress [GO:1900409]; unsaturated fatty acid biosynthetic process [GO:0006636] | endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] | linoleoyl-CoA desaturase activity [GO:0016213]; oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [GO:0016717]; stearoyl-CoA 9-desaturase activity [GO:0004768] | 52172.45691764515 | 0.231450022528831 | 0.00217544618617008 | 0.0131970857503637 |
| Q9NSI2 | Q9NSI2 | SLX9_HUMAN | Ribosome biogenesis protein SLX9 homolog | SLX9 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462] | 90S preribosome [GO:0030686]; nucleolus [GO:0005730]; preribosome, small subunit precursor [GO:0030688] | 9878.883560976996 | 0.521592209334975 | 0.00220250401530883 | 0.0133326792208759 | |
| Q96J42 | Q96J42 | TXD15_HUMAN | Thioredoxin domain-containing protein 15 | TXNDC15 | cilium assembly [GO:0060271]; positive regulation of smoothened signaling pathway [GO:0045880] | ciliary membrane [GO:0060170]; cilium [GO:0005929] | 11747.136997467751 | 0.745390466625704 | 0.0022024725231735 | 0.0133326792208759 | |
| Q8WVY7 | Q8WVY7 | UBCP1_HUMAN | Ubiquitin-like domain-containing CTD phosphatase 1 (EC 3.1.3.16) (Nuclear proteasome inhibitor UBLCP1) | UBLCP1 | negative regulation of ATP-dependent activity [GO:0032780]; protein dephosphorylation [GO:0006470]; regulation of proteasome assembly [GO:0090364] | nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; proteasome regulatory particle binding [GO:1904855]; protein serine/threonine phosphatase activity [GO:0004722] | 25570.99983675745 | 0.241760332768939 | 0.00226224325084564 | 0.013679690778326 |
| O94907 | O94907 | DKK1_HUMAN | Dickkopf-related protein 1 (Dickkopf-1) (Dkk-1) (hDkk-1) (SK) | DKK1 | canonical Wnt signaling pathway [GO:0060070]; cell morphogenesis [GO:0000902]; embryonic limb morphogenesis [GO:0030326]; endocardial cushion development [GO:0003197]; endoderm formation [GO:0001706]; face morphogenesis [GO:0060325]; forebrain development [GO:0030900]; hair follicle development [GO:0001942]; heart induction [GO:0003129]; heart valve development [GO:0003170]; learning or memory [GO:0007611]; limb development [GO:0060173]; mesoderm formation [GO:0001707]; motor learning [GO:0061743]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; negative regulation of mesodermal cell fate specification [GO:0042662]; negative regulation of neuron projection development [GO:0010977]; negative regulation of ossification [GO:0030279]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of presynapse assembly [GO:1905607]; negative regulation of protein binding [GO:0032091]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of Wnt signaling pathway [GO:0030178]; negative regulation of Wnt-Frizzled-LRP5/6 complex assembly [GO:1904723]; positive regulation of gene expression [GO:0010628]; positive regulation of JNK cascade [GO:0046330]; positive regulation of midbrain dopaminergic neuron differentiation [GO:1904958]; positive regulation of Wnt signaling pathway, calcium modulating pathway [GO:0045813]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; regulation of dopaminergic neuron differentiation [GO:1904338]; regulation of endodermal cell fate specification [GO:0042663]; regulation of neuron apoptotic process [GO:0043523]; regulation of receptor internalization [GO:0002090]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to retinoic acid [GO:0032526]; synapse pruning [GO:0098883]; Wnt signaling pathway involved in somitogenesis [GO:0090244] | early endosome membrane [GO:0031901]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] | co-receptor binding [GO:0039706]; growth factor activity [GO:0008083]; low-density lipoprotein particle receptor binding [GO:0050750]; receptor antagonist activity [GO:0048019] | 64306.960832710145 | 0.55828939297577 | 0.00228444794138577 | 0.013799234579842 |
| O00299 | O00299 | CLIC1_HUMAN | Chloride intracellular channel protein 1 (Chloride channel ABP) (Nuclear chloride ion channel 27) (NCC27) (Regulatory nuclear chloride ion channel protein) (hRNCC) | CLIC1 | chloride transport [GO:0006821]; platelet aggregation [GO:0070527]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of mitochondrial membrane potential [GO:0051881]; signal transduction [GO:0007165] | blood microparticle [GO:0072562]; brush border [GO:0005903]; chloride channel complex [GO:0034707]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle [GO:0031982] | cadherin binding [GO:0045296]; chloride channel activity [GO:0005254] | 255652.23380704748 | 0.228759599304298 | 0.00228704504783962 | 0.0138002100543762 |
| Q5TCZ1 | Q5TCZ1 | SPD2A_HUMAN | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | SH3PXD2A | in utero embryonic development [GO:0001701]; osteoclast fusion [GO:0072675]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801] | anchoring junction [GO:0070161]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; podosome [GO:0002102] | phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; protease binding [GO:0002020]; superoxide-generating NADPH oxidase activator activity [GO:0016176] | 6900.378671608595 | -0.574252174301502 | 0.0023082441414348 | 0.0139133098993293 |
| Q9UKX7 | Q9UKX7 | NUP50_HUMAN | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) | NUP50 | mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606] | nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654] | 12656.66437691075 | 0.155807176454114 | 0.00234512771415539 | 0.0141206095944787 | |
| Q12849 | Q12849 | GRSF1_HUMAN | G-rich sequence factor 1 (GRSF-1) | GRSF1 | anterior/posterior pattern specification [GO:0009952]; mitochondrial RNA catabolic process [GO:0000957]; morphogenesis of embryonic epithelium [GO:0016331]; mRNA polyadenylation [GO:0006378]; positive regulation of mitochondrial RNA catabolic process [GO:0000962]; regulation of RNA splicing [GO:0043484]; tRNA processing [GO:0008033] | cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; ribonucleoprotein granule [GO:0035770] | G-quadruplex RNA binding [GO:0002151]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] | 13727.4755218136 | 0.26215084455082 | 0.00238181395673134 | 0.0143168267165294 |
| Q15181 | Q15181 | IPYR_HUMAN | Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) | PPA1 | phosphate-containing compound metabolic process [GO:0006796] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] | inorganic diphosphate phosphatase activity [GO:0004427]; magnesium ion binding [GO:0000287] | 86513.44549199435 | 0.290708895484228 | 0.00242835057352068 | 0.0145752482516612 |
| O94822 | O94822 | LTN1_HUMAN | E3 ubiquitin-protein ligase listerin (EC 2.3.2.27) (RING finger protein 160) (RING-type E3 ubiquitin transferase listerin) (Zinc finger protein 294) | LTN1 | protein autoubiquitination [GO:0051865]; rescue of stalled ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116] | cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; RQC complex [GO:1990112] | ribosomal large subunit binding [GO:0043023]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] | 5095.07143677412 | -0.31189120841914 | 0.00244592549320011 | 0.0146651998354199 |
| Q8NE71 | Q8NE71 | ABCF1_HUMAN | ATP-binding cassette sub-family F member 1 (ATP-binding cassette 50) (TNF-alpha-stimulated ABC protein) | ABCF1 | inflammatory response [GO:0006954]; positive regulation of translation [GO:0045727]; translation [GO:0006412]; translational initiation [GO:0006413] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation activator activity [GO:0008494]; translation factor activity, RNA binding [GO:0008135] | 40699.53641705045 | 0.177997451208139 | 0.00246047967868424 | 0.0147368687731764 |
| Q9Y5K6 | Q9Y5K6 | CD2AP_HUMAN | CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains) | CD2AP | actin filament organization [GO:0007015]; actin filament polymerization [GO:0030041]; adipose tissue development [GO:0060612]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction organization [GO:0045216]; collateral sprouting [GO:0048668]; endothelium development [GO:0003158]; ERK1 and ERK2 cascade [GO:0070371]; filopodium assembly [GO:0046847]; glucose import [GO:0046323]; immunological synapse formation [GO:0001771]; inflammatory response [GO:0006954]; lipid metabolic process [GO:0006629]; liver development [GO:0001889]; localization of cell [GO:0051674]; lymph node development [GO:0048535]; maintenance of blood-brain barrier [GO:0035633]; male gonad development [GO:0008584]; membrane organization [GO:0061024]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; negative regulation of transforming growth factor beta1 production [GO:0032911]; nerve growth factor signaling pathway [GO:0038180]; neurotrophin TRK receptor signaling pathway [GO:0048011]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; podocyte differentiation [GO:0072112]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein secretion [GO:0050714]; protein catabolic process [GO:0030163]; protein heterooligomerization [GO:0051291]; protein secretion [GO:0009306]; protein-containing complex assembly [GO:0065003]; Rab protein signal transduction [GO:0032482]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of synaptic plasticity [GO:0048167]; renal albumin absorption [GO:0097018]; response to glial cell derived neurotrophic factor [GO:1990790]; response to insulin [GO:0032868]; response to oxidative stress [GO:0006979]; response to transforming growth factor beta [GO:0071559]; response to virus [GO:0009615]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; stress-activated MAPK cascade [GO:0051403]; substrate-dependent cell migration, cell extension [GO:0006930]; synapse organization [GO:0050808]; T cell receptor signaling pathway [GO:0050852]; transforming growth factor beta1 production [GO:0032905] | actin cytoskeleton [GO:0015629]; axon [GO:0030424]; cell leading edge [GO:0031252]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; filamentous actin [GO:0031941]; growth cone [GO:0030426]; late endosome [GO:0005770]; neuromuscular junction [GO:0031594]; nuclear envelope lumen [GO:0005641]; plasma membrane [GO:0005886]; podosome [GO:0002102]; ruffle [GO:0001726]; slit diaphragm [GO:0036057]; trans-Golgi network membrane [GO:0032588]; vesicle [GO:0031982] | actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; clathrin binding [GO:0030276]; identical protein binding [GO:0042802]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; SH3 domain binding [GO:0017124]; structural constituent of cytoskeleton [GO:0005200] | 21239.576815472552 | 0.299366533793003 | 0.00246580979601281 | 0.0147531977869151 |
| Q8WU79 | Q8WU79 | SMAP2_HUMAN | Stromal membrane-associated protein 2 (Stromal membrane-associated protein 1-like) | SMAP2 | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] | GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] | 22104.412383157 | 0.219269783165249 | 0.00247936688912504 | 0.0148186632845807 | |
| P78527 | P78527 | PRKDC_HUMAN | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460) | PRKDC | activation of innate immune response [GO:0002218]; B cell lineage commitment [GO:0002326]; brain development [GO:0007420]; cellular response to insulin stimulus [GO:0032869]; DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; double-strand break repair via nonhomologous end joining [GO:0006303]; ectopic germ cell programmed cell death [GO:0035234]; heart development [GO:0007507]; immature B cell differentiation [GO:0002327]; immunoglobulin V(D)J recombination [GO:0033152]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; maturation of 5.8S rRNA [GO:0000460]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cGAS/STING signaling pathway [GO:0160049]; negative regulation of protein phosphorylation [GO:0001933]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of apoptotic process [GO:0043065]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of lymphocyte differentiation [GO:0045621]; positive regulation of platelet formation [GO:1905221]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; pro-B cell differentiation [GO:0002328]; protein destabilization [GO:0031648]; protein modification process [GO:0036211]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; regulation of epithelial cell proliferation [GO:0050678]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of smooth muscle cell proliferation [GO:0048660]; response to gamma radiation [GO:0010332]; rhythmic process [GO:0048511]; small-subunit processome assembly [GO:0034462]; somitogenesis [GO:0001756]; T cell differentiation in thymus [GO:0033077]; T cell lineage commitment [GO:0002360]; T cell receptor V(D)J recombination [GO:0033153]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723] | chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; DNA-dependent protein kinase complex [GO:0070418]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; membrane [GO:0016020]; nonhomologous end joining complex [GO:0070419]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; small-subunit processome [GO:0032040]; transcription regulator complex [GO:0005667] | ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; histone H2AXS139 kinase activity [GO:0035979]; protein domain specific binding [GO:0019904]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; U3 snoRNA binding [GO:0034511] | 17519.22863824745 | -0.32515749546193 | 0.00248824549343026 | 0.0148560579196795 |
| P00505 | P00505 | AATM_HUMAN | Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A) | GOT2 | 2-oxoglutarate metabolic process [GO:0006103]; 4-hydroxyproline catabolic process [GO:0019470]; aspartate biosynthetic process [GO:0006532]; aspartate catabolic process [GO:0006533]; aspartate metabolic process [GO:0006531]; fatty acid transport [GO:0015908]; glutamate catabolic process to 2-oxoglutarate [GO:0019551]; glutamate catabolic process to aspartate [GO:0019550]; glutamate metabolic process [GO:0006536]; oxaloacetate metabolic process [GO:0006107]; response to ethanol [GO:0045471] | extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] | kynurenine-oxoglutarate transaminase activity [GO:0016212]; L-aspartate:2-oxoglutarate aminotransferase activity [GO:0004069]; pyridoxal phosphate binding [GO:0030170]; RNA binding [GO:0003723] | 35605.4322806611 | 0.152368618961942 | 0.00249324917575509 | 0.0148702629787667 |
| P51809 | P51809 | VAMP7_HUMAN | Vesicle-associated membrane protein 7 (VAMP-7) (Synaptobrevin-like protein 1) (Tetanus-insensitive VAMP) (Ti-VAMP) | VAMP7 | calcium-ion regulated exocytosis [GO:0017156]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endosome to lysosome transport [GO:0008333]; eosinophil degranulation [GO:0043308]; exocytosis [GO:0006887]; natural killer cell degranulation [GO:0043320]; neutrophil degranulation [GO:0043312]; phagocytosis, engulfment [GO:0006911]; positive regulation of histamine secretion by mast cell [GO:1903595]; protein transport [GO:0015031]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192] | azurophil granule membrane [GO:0035577]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; neuron projection [GO:0043005]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; pseudopodium [GO:0031143]; secretory granule [GO:0030141]; secretory granule membrane [GO:0030667]; SNARE complex [GO:0031201]; synapse [GO:0045202]; trans-Golgi network [GO:0005802]; transport vesicle membrane [GO:0030658] | SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] | 12715.0952596797 | -0.862612161307414 | 0.00253965583476748 | 0.0151311145739144 |
| P04264 | P04264 | K2C1_HUMAN | Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1) | KRT1 | complement activation, lectin pathway [GO:0001867]; establishment of skin barrier [GO:0061436]; fibrinolysis [GO:0042730]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; negative regulation of inflammatory response [GO:0050728]; peptide cross-linking [GO:0018149]; protein heterotetramerization [GO:0051290]; regulation of angiogenesis [GO:0045765]; response to oxidative stress [GO:0006979] | blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; keratin filament [GO:0045095]; membrane [GO:0016020]; nucleus [GO:0005634] | carbohydrate binding [GO:0030246]; protein heterodimerization activity [GO:0046982]; signaling receptor activity [GO:0038023]; structural constituent of skin epidermis [GO:0030280] | 55734.6251277163 | -1.76707564326161 | 0.00255695218501437 | 0.0152181628994658 |
| P50213 | P50213 | IDH3A_HUMAN | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha) | IDH3A | carbohydrate metabolic process [GO:0005975]; isocitrate metabolic process [GO:0006102]; tricarboxylic acid cycle [GO:0006099] | mitochondrial isocitrate dehydrogenase complex (NAD+) [GO:0005962]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634] | isocitrate dehydrogenase (NAD+) activity [GO:0004449]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287] | 32528.14528599025 | 0.236171577478586 | 0.00261101004372601 | 0.0155073196098025 |
| Q15120 | Q15120 | PDK3_HUMAN | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3) | PDK3 | cellular response to fatty acid [GO:0071398]; cellular response to glucose stimulus [GO:0071333]; hypoxia-inducible factor-1alpha signaling pathway [GO:0097411]; peptidyl-serine phosphorylation [GO:0018105]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0010510]; regulation of glucose metabolic process [GO:0010906]; regulation of reactive oxygen species metabolic process [GO:2000377] | mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730] | ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; pyruvate dehydrogenase (acetyl-transferring) kinase activity [GO:0004740] | 10119.068489538764 | 0.828421853343654 | 0.00263574777707702 | 0.0156378501622182 |
| P61421 | P61421 | VA0D1_HUMAN | V-type proton ATPase subunit d 1 (V-ATPase subunit d 1) (32 kDa accessory protein) (V-ATPase 40 kDa accessory protein) (V-ATPase AC39 subunit) (p39) (Vacuolar proton pump subunit d 1) | ATP6V0D1 | cellular response to increased oxygen levels [GO:0036295]; cilium assembly [GO:0060271]; intracellular iron ion homeostasis [GO:0006879]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]; vacuolar transport [GO:0007034] | apical plasma membrane [GO:0016324]; axon terminus [GO:0043679]; clathrin-coated vesicle membrane [GO:0030665]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; phagocytic vesicle membrane [GO:0030670]; plasma membrane proton-transporting V-type ATPase complex [GO:0033181]; synaptic vesicle membrane [GO:0030672]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220] | protein-containing complex binding [GO:0044877]; proton-transporting ATPase activity, rotational mechanism [GO:0046961] | 62624.71753898455 | -0.16670740990885 | 0.00263925977567149 | 0.0156423074152246 |
| P62312 | P62312 | LSM6_HUMAN | U6 snRNA-associated Sm-like protein LSm6 | LSM6 | maturation of SSU-rRNA [GO:0030490]; mRNA catabolic process [GO:0006402]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; tRNA processing [GO:0008033] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; Lsm2-8 complex [GO:0120115]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; small nuclear ribonucleoprotein complex [GO:0030532]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688] | protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723] | 11633.314451608374 | -1.31005614507971 | 0.00264578962253019 | 0.0156472274618355 |
| O15460 | O15460 | P4HA2_HUMAN | Prolyl 4-hydroxylase subunit alpha-2 (4-PH alpha-2) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2) | P4HA2 | cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] | electron transfer activity [GO:0009055]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 4-dioxygenase activity [GO:0004656] | 580880.9728732426 | -0.192603589468006 | 0.00264604296772715 | 0.0156472274618355 | |
| Q53EL6 | Q53EL6 | PDCD4_HUMAN | Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) | PDCD4 | apoptotic process [GO:0006915]; BMP signaling pathway [GO:0030509]; cellular response to lipopolysaccharide [GO:0071222]; epithelial to mesenchymal transition involved in cardiac fibroblast development [GO:0060940]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of myofibroblast differentiation [GO:1904761]; negative regulation of vascular associated smooth muscle cell differentiation [GO:1905064]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of inflammatory response [GO:0050729]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; response to alkaloid [GO:0043279]; response to hormone [GO:0009725] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] | RNA binding [GO:0003723] | 12711.11718638355 | -0.72775324428001 | 0.00270273641546681 | 0.015935176410026 |
| P47985 | P47985 | UCRI_HUMAN | Cytochrome b-c1 complex subunit Rieske, mitochondrial (EC 7.1.1.8) (Complex III subunit 5) (Cytochrome b-c1 complex subunit 5) (Rieske iron-sulfur protein) (RISP) (Rieske protein UQCRFS1) (Ubiquinol-cytochrome c reductase iron-sulfur subunit) [Cleaved into: Cytochrome b-c1 complex subunit 9 (Su9) (Subunit 9) (8 kDa subunit 9) (Complex III subunit IX) (Cytochrome b-c1 complex subunit 11) (UQCRFS1 mitochondrial targeting sequence) (UQCRFS1 MTS) (Ubiquinol-cytochrome c reductase 8 kDa protein)] | UQCRFS1 | mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; mitochondrial respiratory chain complex III assembly [GO:0034551]; respiratory electron transport chain [GO:0022904] | mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex III [GO:0005750]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] | 2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; ubiquinol-cytochrome-c reductase activity [GO:0008121] | 61543.191208158096 | 0.463924517029371 | 0.00272232375628624 | 0.0160339775500185 |
| Q8TDB4 | Q8TDB4 | HUMMR_HUMAN | Protein MGARP (Corneal endothelium-specific protein 1) (CESP-1) (Hypoxia up-regulated mitochondrial movement regulator protein) (Mitochondria-localized glutamic acid-rich protein) (Ovary-specific acidic protein) | MGARP | anterograde axonal transport [GO:0008089]; axon development [GO:0061564]; axonal transport of mitochondrion [GO:0019896]; cellular response to gonadotropin-releasing hormone [GO:0097211]; cellular response to hypoxia [GO:0071456]; cellular response to steroid hormone stimulus [GO:0071383]; cerebral cortex development [GO:0021987]; negative regulation of dendrite development [GO:2000171]; protein targeting to mitochondrion [GO:0006626]; regulation of mitochondrion organization [GO:0010821]; retrograde axonal transport [GO:0008090] | axon cytoplasm [GO:1904115]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] | 10763.11382336405 | 0.626383028677613 | 0.00273374852781495 | 0.0160845474128759 | |
| O75629 | O75629 | CREG1_HUMAN | Protein CREG1 (Cellular repressor of E1A-stimulated genes 1) | CREG1 | autophagy [GO:0006914]; endocytosis [GO:0006897]; lysosomal lumen acidification [GO:0007042]; regulation of transcription by RNA polymerase II [GO:0006357] | azurophil granule lumen [GO:0035578]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; transcription regulator complex [GO:0005667] | transcription corepressor activity [GO:0003714] | 33899.4206364038 | 1.05852011624308 | 0.00273741072455921 | 0.0160893871009881 |
| P61970 | P61970 | NTF2_HUMAN | Nuclear transport factor 2 (NTF-2) (Placental protein 15) (PP15) | NUTF2 | mRNA transport [GO:0051028]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; protein localization to nuclear pore [GO:0090204] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; nuclear pore central transport channel [GO:0044613]; nucleoplasm [GO:0005654] | identical protein binding [GO:0042802]; nuclear import signal receptor activity [GO:0061608]; small GTPase binding [GO:0031267]; structural constituent of nuclear pore [GO:0017056] | 23639.46203803365 | -0.631429891451188 | 0.00274879491833682 | 0.016139556484245 |
| Q8IY95 | Q8IY95 | TM192_HUMAN | Transmembrane protein 192 | TMEM192 | endosome [GO:0005768]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471] | protein homodimerization activity [GO:0042803] | 11661.96299474375 | -0.303865890411395 | 0.00275805501334224 | 0.0161771632563117 | |
| P07711 | P07711 | CATL1_HUMAN | Procathepsin L (EC 3.4.22.15) (Cathepsin L1) (Major excreted protein) (MEP) [Cleaved into: Cathepsin L; Cathepsin L heavy chain; Cathepsin L light chain] | CTSL | adaptive immune response [GO:0002250]; antigen processing and presentation [GO:0019882]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antigen processing and presentation of peptide antigen [GO:0048002]; CD4-positive, alpha-beta T cell lineage commitment [GO:0043373]; cellular response to thyroid hormone stimulus [GO:0097067]; collagen catabolic process [GO:0030574]; elastin catabolic process [GO:0060309]; enkephalin processing [GO:0034230]; fusion of virus membrane with host endosome membrane [GO:0039654]; fusion of virus membrane with host plasma membrane [GO:0019064]; immune response [GO:0006955]; macrophage apoptotic process [GO:0071888]; positive regulation of apoptotic signaling pathway [GO:2001235]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; symbiont entry into host cell [GO:0046718]; zymogen activation [GO:0031638] | apical plasma membrane [GO:0016324]; chromaffin granule [GO:0042583]; collagen-containing extracellular matrix [GO:0062023]; endocytic vesicle lumen [GO:0071682]; endolysosome lumen [GO:0036021]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; multivesicular body [GO:0005771]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | collagen binding [GO:0005518]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; fibronectin binding [GO:0001968]; histone binding [GO:0042393]; proteoglycan binding [GO:0043394]; serpin family protein binding [GO:0097655] | 78271.44261612535 | 0.291388654216506 | 0.00280018101095409 | 0.0163734010403156 |
| Q16850 | Q16850 | CP51A_HUMAN | Lanosterol 14-alpha demethylase (LDM) (EC 1.14.14.154) (CYPLI) (Cytochrome P450 51A1) (CYP51A1) (Cytochrome P450-14DM) (Cytochrome P45014DM) (Cytochrome P450LI) (Sterol 14-alpha demethylase) | CYP51A1 | bile acid biosynthetic process [GO:0006699]; cholesterol biosynthetic process [GO:0006695]; cholesterol homeostasis [GO:0042632]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein secretion [GO:0050709]; steroid biosynthetic process [GO:0006694]; sterol metabolic process [GO:0016125] | endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] | heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity [GO:0016491]; oxysterol 7-alpha-hydroxylase activity [GO:0008396]; steroid 7-alpha-hydroxylase activity [GO:0008387]; sterol 14-demethylase activity [GO:0008398] | 10918.0974979694 | 0.179838316881687 | 0.00279915232672612 | 0.0163734010403156 |
| P23470 | P23470 | PTPRG_HUMAN | Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48) | PTPRG | dephosphorylation [GO:0016311]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of neuron projection development [GO:0010977]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] | extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] | identical protein binding [GO:0042802]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001] | 3744.503521950785 | 0.554887840408801 | 0.00279631583139078 | 0.0163734010403156 |
| P40222 | P40222 | TXLNA_HUMAN | Alpha-taxilin | TXLNA | B cell activation [GO:0042113]; exocytosis [GO:0006887] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020] | syntaxin binding [GO:0019905] | 34222.061548405356 | 0.11148949709462 | 0.00287900101935816 | 0.0168169276037972 |
| Q9NVA2 | Q9NVA2 | SEP11_HUMAN | Septin-11 | SEPTIN11 | cilium assembly [GO:0060271]; cytoskeleton-dependent cytokinesis [GO:0061640]; regulation of synapse organization [GO:0050807] | axon [GO:0030424]; cell division site [GO:0032153]; dendritic spine [GO:0043197]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; microtubule cytoskeleton [GO:0015630]; postsynaptic specialization of symmetric synapse [GO:0099629]; septin complex [GO:0031105]; septin ring [GO:0005940]; stress fiber [GO:0001725] | GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090] | 133488.8728429155 | -0.212950329134757 | 0.00290469065072359 | 0.0169495131071059 |
| Q9NZD2 | Q9NZD2 | GLTP_HUMAN | Glycolipid transfer protein (GLTP) | GLTP | ceramide transport [GO:0035627]; ER to Golgi ceramide transport [GO:0035621]; intermembrane lipid transfer [GO:0120009]; response to immobilization stress [GO:0035902] | cytosol [GO:0005829] | ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388]; glycolipid binding [GO:0051861]; glycolipid transfer activity [GO:0017089]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; lipid transfer activity [GO:0120013] | 12642.14017264155 | -0.60065463417395 | 0.00295005662450496 | 0.0171965234922274 |
| Q9P0J7 | Q9P0J7 | KCMF1_HUMAN | E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (RING-type E3 ubiquitin transferase KCMF1) (ZZ-type zinc finger-containing protein 1) | KCMF1 | synaptic signaling [GO:0099536] | cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; plasma membrane [GO:0005886]; synapse [GO:0045202] | ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] | 17295.2413594469 | 0.458023312321375 | 0.00295450449675113 | 0.0172047507488098 |
| Q9NQZ5 | Q9NQZ5 | STAR7_HUMAN | StAR-related lipid transfer protein 7, mitochondrial (Gestational trophoblastic tumor protein 1) (START domain-containing protein 7) (StARD7) | STARD7 | mitochondrial outer membrane [GO:0005741] | lipid binding [GO:0008289] | 9125.145570068566 | 1.42292253025968 | 0.00296067034586365 | 0.0172229550099214 | |
| O95782 | O95782 | AP2A1_HUMAN | AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit) | AP2A1 | clathrin-dependent endocytosis [GO:0072583]; endocytosis [GO:0006897]; Golgi to endosome transport [GO:0006895]; intracellular protein transport [GO:0006886]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; positive regulation of neuron projection development [GO:0010976]; positive regulation of receptor-mediated endocytosis [GO:0048260]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; vesicle-mediated transport [GO:0016192] | AP-2 adaptor complex [GO:0030122]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endolysosome membrane [GO:0036020]; filopodium tip [GO:0032433]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] | clathrin adaptor activity [GO:0035615]; low-density lipoprotein particle receptor binding [GO:0050750]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877] | 40136.82042763585 | -0.258033720532222 | 0.00296761143605161 | 0.0172279573736357 |
| Q92743 | Q92743 | HTRA1_HUMAN | Serine protease HTRA1 (EC 3.4.21.-) (High-temperature requirement A serine peptidase 1) (L56) (Serine protease 11) | HTRA1 | chorionic trophoblast cell differentiation [GO:0060718]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; placenta development [GO:0001890]; positive regulation of apoptotic process [GO:0043065]; programmed cell death [GO:0012501]; proteolysis [GO:0006508] | collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] | growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; molecular function activator activity [GO:0140677]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] | 8257.201113897585 | 0.336816597544043 | 0.00296736358082579 | 0.0172279573736357 |
| Q9H444 | Q9H444 | CHM4B_HUMAN | Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b) (SNF7 homolog associated with Alix 1) (SNF7-2) (hSnf7-2) (Vacuolar protein sorting-associated protein 32-2) (Vps32-2) (hVps32-2) | CHMP4B | autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; exit from mitosis [GO:0010458]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; macroautophagy [GO:0016236]; maintenance of lens transparency [GO:0036438]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic cytokinesis [GO:0000281]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nervous system process [GO:0050877]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; protein polymerization [GO:0051258]; protein transport [GO:0015031]; regulation of autophagy [GO:0010506]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; vesicle budding from membrane [GO:0006900]; vesicle fusion with vacuole [GO:0051469]; viral budding [GO:0046755]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702] | amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endosome [GO:0005768]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; membrane coat [GO:0030117]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle [GO:0031982] | cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] | 41786.195956183205 | 0.390717280496894 | 0.00301096104646663 | 0.017461724963439 |
| O95218 | O95218 | ZRAB2_HUMAN | Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) (Zinc finger, splicing) | ZRANB2 | mRNA processing [GO:0006397]; RNA splicing [GO:0008380] | nucleoplasm [GO:0005654] | lipopolysaccharide binding [GO:0001530]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] | 31190.792871213947 | 0.574216386076968 | 0.00303820521084937 | 0.0176017083074361 |
| Q8N5I4 | Q8N5I4 | DHRSX_HUMAN | Dehydrogenase/reductase SDR family member on chromosome X (EC 1.1.-.-) (DHRSXY) (Short chain dehydrogenase/reductase family 46C member 1) (Short chain dehydrogenase/reductase family 7C member 6) | DHRSX | positive regulation of autophagy [GO:0010508] | extracellular region [GO:0005576] | oxidoreductase activity [GO:0016491] | 7412.23609151035 | -0.560835089874876 | 0.0030593627692844 | 0.017706179214265 |
| O15254 | O15254 | ACOX3_HUMAN | Peroxisomal acyl-coenzyme A oxidase 3 (EC 1.3.3.6) (Branched-chain acyl-CoA oxidase) (BRCACox) (Pristanoyl-CoA oxidase) | ACOX3 | fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; lipid homeostasis [GO:0055088] | cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] | FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; flavin adenine dinucleotide binding [GO:0050660]; pristanoyl-CoA oxidase activity [GO:0016402] | 3338.690575499295 | -0.700001689640784 | 0.00312210183885111 | 0.0180508459376841 |
| P30405 | P30405 | PPIF_HUMAN | Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin D) (CyP-D) (CypD) (Cyclophilin F) (Mitochondrial cyclophilin) (CyP-M) (Rotamase F) | PPIF | apoptotic mitochondrial changes [GO:0008637]; cellular response to arsenic-containing substance [GO:0071243]; cellular response to calcium ion [GO:0071277]; cellular response to hydrogen peroxide [GO:0070301]; mitochondrial depolarization [GO:0051882]; mitochondrial outer membrane permeabilization involved in programmed cell death [GO:1902686]; necroptotic process [GO:0070266]; negative regulation of apoptotic process [GO:0043066]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of oxidative phosphorylation [GO:0090324]; negative regulation of oxidative phosphorylation uncoupler activity [GO:2000276]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; regulation of mitochondrial membrane permeability [GO:0046902]; regulation of mitochondrial membrane permeability involved in programmed necrotic cell death [GO:1902445]; regulation of proton-transporting ATPase activity, rotational mechanism [GO:0010849]; response to ischemia [GO:0002931]; skeletal muscle fiber differentiation [GO:0098528] | cytoplasm [GO:0005737]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739] | cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755] | 10355.33610671966 | 0.880756805486594 | 0.00313661558271755 | 0.0181162730802015 |
| O00115 | O00115 | DNS2A_HUMAN | Deoxyribonuclease-2-alpha (EC 3.1.22.1) (Acid DNase) (Deoxyribonuclease II alpha) (DNase II alpha) (Lysosomal DNase II) (R31240_2) | DNASE2 | apoptotic DNA fragmentation [GO:0006309]; DNA metabolic process [GO:0006259]; enucleate erythrocyte differentiation [GO:0043353]; regulation of immune response [GO:0050776] | extracellular exosome [GO:0070062]; lysosome [GO:0005764] | deoxyribonuclease II activity [GO:0004531]; DNA binding [GO:0003677] | 78787.9977482825 | 0.332955838826118 | 0.00316152218407709 | 0.0182415322759478 |
| Q24JP5 | Q24JP5 | T132A_HUMAN | Transmembrane protein 132A (HSPA5-binding protein 1) | TMEM132A | negative regulation of protein catabolic process [GO:0042177]; positive regulation of Wnt protein secretion [GO:0061357]; positive regulation of Wnt signaling pathway [GO:0030177] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] | protein homodimerization activity [GO:0042803] | 4435.01576102964 | 0.894133010428033 | 0.0031837112916771 | 0.0183508730199822 |
| Q14444 | Q14444 | CAPR1_HUMAN | Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105) | CAPRIN1 | generation of neurons [GO:0048699]; intracellular mRNA localization [GO:0008298]; negative regulation of translation [GO:0017148]; non-membrane-bounded organelle assembly [GO:0140694]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of stress granule assembly [GO:0062029]; regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0106288]; synapse assembly [GO:0007416] | cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; intracellular non-membrane-bounded organelle [GO:0043232]; lamellipodium [GO:0030027]; membrane [GO:0016020]; P-body [GO:0000932]; synapse [GO:0045202] | ATP binding [GO:0005524]; molecular condensate scaffold activity [GO:0140693]; molecular function activator activity [GO:0140677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; signaling adaptor activity [GO:0035591] | 38329.83148880545 | 0.168112859852982 | 0.00318774881560746 | 0.0183554723467804 |
| O15127 | O15127 | SCAM2_HUMAN | Secretory carrier-associated membrane protein 2 (Secretory carrier membrane protein 2) | SCAMP2 | post-Golgi vesicle-mediated transport [GO:0006892]; protein transport [GO:0015031] | extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; recycling endosome membrane [GO:0055038]; trans-Golgi network membrane [GO:0032588] | 40651.15285624305 | -1.08729659858967 | 0.00324257583281471 | 0.0186522179377951 | |
| P04083 | P04083 | ANXA1_HUMAN | Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] | ANXA1 | actin cytoskeleton organization [GO:0030036]; adaptive immune response [GO:0002250]; alpha-beta T cell differentiation [GO:0046632]; arachidonic acid secretion [GO:0050482]; cell surface receptor signaling pathway [GO:0007166]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; DNA duplex unwinding [GO:0032508]; endocrine pancreas development [GO:0031018]; estrous cycle [GO:0044849]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; gliogenesis [GO:0042063]; granulocyte chemotaxis [GO:0071621]; hepatocyte differentiation [GO:0070365]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; insulin secretion [GO:0030073]; keratinocyte differentiation [GO:0030216]; localization [GO:0051179]; monocyte chemotaxis [GO:0002548]; myoblast migration involved in skeletal muscle regeneration [GO:0014839]; negative regulation of apoptotic process [GO:0043066]; negative regulation of exocytosis [GO:0045920]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of T-helper 2 cell differentiation [GO:0045629]; neutrophil activation [GO:0042119]; neutrophil clearance [GO:0097350]; neutrophil homeostasis [GO:0001780]; peptide cross-linking [GO:0018149]; phagocytosis [GO:0006909]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of neutrophil apoptotic process [GO:0033031]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 1 cell differentiation [GO:0045627]; positive regulation of vesicle fusion [GO:0031340]; positive regulation of wound healing [GO:0090303]; prolactin secretion [GO:0070459]; prostate gland development [GO:0030850]; regulation of cell shape [GO:0008360]; regulation of hormone secretion [GO:0046883]; regulation of inflammatory response [GO:0050727]; regulation of interleukin-1 production [GO:0032652]; regulation of leukocyte migration [GO:0002685]; response to estradiol [GO:0032355]; response to interleukin-1 [GO:0070555]; response to peptide hormone [GO:0043434]; response to X-ray [GO:0010165]; signal transduction [GO:0007165] | adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; lateral plasma membrane [GO:0016328]; motile cilium [GO:0031514]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; vesicle [GO:0031982] | cadherin binding involved in cell-cell adhesion [GO:0098641]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; lipid binding [GO:0008289]; phosphatidylserine binding [GO:0001786]; phospholipase A2 inhibitor activity [GO:0019834]; phospholipid binding [GO:0005543]; signaling receptor binding [GO:0005102] | 697769.386189773 | 0.197349537962783 | 0.003284681273658 | 0.018875257704408 |
| Q96GQ5 | Q96GQ5 | RUSF1_HUMAN | RUS family member 1 | RUSF1 | membrane [GO:0016020] | 9290.313936177165 | -0.656213353717823 | 0.00330287275193108 | 0.0189605643489782 | ||
| P19623 | P19623 | SPEE_HUMAN | Spermidine synthase (SPDSY) (EC 2.5.1.16) (Putrescine aminopropyltransferase) | SRM | cellular response to leukemia inhibitory factor [GO:1990830]; polyamine metabolic process [GO:0006595]; spermidine biosynthetic process [GO:0008295] | cytosol [GO:0005829] | identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; spermidine synthase activity [GO:0004766] | 180621.731870959 | -0.0822883286302784 | 0.00330958514719597 | 0.0189672937026419 |
| Q9C0C9 | Q9C0C9 | UBE2O_HUMAN | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | UBE2O | positive regulation of BMP signaling pathway [GO:0030513]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; retrograde transport, endosome to Golgi [GO:0042147] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | ATP binding [GO:0005524]; RNA binding [GO:0003723]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] | 10098.47732154126 | 0.324465424658827 | 0.00331074011152716 | 0.0189672937026419 |
| Q92629 | Q92629 | SGCD_HUMAN | Delta-sarcoglycan (Delta-SG) (35 kDa dystrophin-associated glycoprotein) (35DAG) | SGCD | calcium ion homeostasis [GO:0055074]; calcium-mediated signaling [GO:0019722]; cardiac muscle cell contraction [GO:0086003]; cardiac muscle cell development [GO:0055013]; cardiac muscle tissue development [GO:0048738]; coronary vasculature morphogenesis [GO:0060977]; heart contraction [GO:0060047]; muscle organ development [GO:0007517]; protein-containing complex localization [GO:0031503] | cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; plasma membrane [GO:0005886]; sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529] | 10008.626975277075 | -1.78026111214267 | 0.00333163253439297 | 0.0190677070099703 | |
| Q6P1L8 | Q6P1L8 | RM14_HUMAN | Large ribosomal subunit protein uL14m (39S ribosomal protein L14, mitochondrial) (L14mt) (MRP-L14) (39S ribosomal protein L32, mitochondrial) (L32mt) (MRP-L32) | MRPL14 | mitochondrial translation [GO:0032543] | mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 11975.6123383236 | 0.514898736285525 | 0.00334295754676448 | 0.0191132164076363 |
| P04156 | P04156 | PRIO_HUMAN | Major prion protein (PrP) (ASCR) (PrP27-30) (PrP33-35C) (CD antigen CD230) | PRNP | calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell cycle [GO:0007049]; cellular response to amyloid-beta [GO:1904646]; cellular response to copper ion [GO:0071280]; cellular response to xenobiotic stimulus [GO:0071466]; dendritic spine maintenance [GO:0097062]; intracellular copper ion homeostasis [GO:0006878]; learning or memory [GO:0007611]; long-term memory [GO:0007616]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of amyloid precursor protein catabolic process [GO:1902992]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of apoptotic process [GO:0043066]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of dendritic spine maintenance [GO:1902951]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein processing [GO:0010955]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of type II interferon production [GO:0032689]; neuron projection maintenance [GO:1990535]; positive regulation of glutamate receptor signaling pathway [GO:1900451]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein targeting to membrane [GO:0090314]; protein destabilization [GO:0031648]; protein homooligomerization [GO:0051260]; regulation of calcium ion import across plasma membrane [GO:1905664]; regulation of cell cycle [GO:0051726]; regulation of glutamate receptor signaling pathway [GO:1900449]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of potassium ion transmembrane transport [GO:1901379]; response to amyloid-beta [GO:1904645]; response to cadmium ion [GO:0046686]; response to oxidative stress [GO:0006979] | cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extrinsic component of membrane [GO:0019898]; Golgi apparatus [GO:0005794]; inclusion body [GO:0016234]; intracellular membrane-bounded organelle [GO:0043231]; membrane raft [GO:0045121]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; terminal bouton [GO:0043195] | amyloid-beta binding [GO:0001540]; aspartic-type endopeptidase inhibitor activity [GO:0019828]; ATP-dependent protein binding [GO:0043008]; copper ion binding [GO:0005507]; cupric ion binding [GO:1903135]; cuprous ion binding [GO:1903136]; glycosaminoglycan binding [GO:0005539]; identical protein binding [GO:0042802]; lamin binding [GO:0005521]; microtubule binding [GO:0008017]; molecular adaptor activity [GO:0060090]; molecular condensate scaffold activity [GO:0140693]; molecular function activator activity [GO:0140677]; protease binding [GO:0002020]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; signaling receptor activity [GO:0038023]; transmembrane transporter binding [GO:0044325]; tubulin binding [GO:0015631]; type 5 metabotropic glutamate receptor binding [GO:0031802] | 61537.572406388455 | 0.669434747799249 | 0.0033539746224027 | 0.0191568752122316 |
| Q9NYM9 | Q9NYM9 | BET1L_HUMAN | BET1-like protein (Golgi SNARE with a size of 15 kDa) (GOS-15) (GS15) (Vesicle transport protein GOS15) | BET1L | protein transport [GO:0015031]; regulation of retrograde vesicle-mediated transport, Golgi to ER [GO:2000156]; retrograde transport, endosome to Golgi [GO:0042147] | cytosol [GO:0005829]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; SNARE complex [GO:0031201] | SNAP receptor activity [GO:0005484] | 20103.315567014048 | -1.50763846735696 | 0.00339677643019449 | 0.0193818079088439 |
| Q8N3V7 | Q8N3V7 | SYNPO_HUMAN | Synaptopodin | SYNPO | modification of dendritic spine [GO:0098886]; positive regulation of actin filament bundle assembly [GO:0032233]; regulation of stress fiber assembly [GO:0051492]; spine apparatus assembly [GO:1905355] | actin cytoskeleton [GO:0015629]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; spine apparatus [GO:0097444]; stress fiber [GO:0001725]; Z disc [GO:0030018] | actin binding [GO:0003779] | 7142.996872062835 | 0.358162665621543 | 0.00341103678176496 | 0.0194435959813685 |
| Q5RI15 | Q5RI15 | COX20_HUMAN | Cytochrome c oxidase assembly protein COX20, mitochondrial | COX20 | mitochondrial cytochrome c oxidase assembly [GO:0033617] | mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] | 43124.8319103631 | 0.340784932271479 | 0.00341553658133294 | 0.0194496786631482 | |
| Q92499 | Q92499 | DDX1_HUMAN | ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB) | DDX1 | defense response to virus [GO:0051607]; DNA duplex unwinding [GO:0032508]; double-strand break repair [GO:0006302]; innate immune response [GO:0045087]; nucleic acid metabolic process [GO:0090304]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; protein localization to cytoplasmic stress granule [GO:1903608]; regulation of translational initiation [GO:0006446]; response to exogenous dsRNA [GO:0043330]; rRNA processing [GO:0006364]; spliceosomal complex assembly [GO:0000245]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388] | cleavage body [GO:0071920]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; tRNA-splicing ligase complex [GO:0072669] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA/RNA helicase activity [GO:0033677]; double-stranded RNA binding [GO:0003725]; exonuclease activity [GO:0004527]; nuclease activity [GO:0004518]; poly(A) binding [GO:0008143]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; transcription coregulator activity [GO:0003712] | 38764.24122610895 | -0.105376967585163 | 0.00343030749912415 | 0.0195141790060617 |
| Q01105 | Q01105 | SET_HUMAN | Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) | SET | DNA replication [GO:0006260]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron apoptotic process [GO:0043524]; nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337] | chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991] | chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; protein phosphatase inhibitor activity [GO:0004864]; protein phosphatase regulator activity [GO:0019888] | 210597.4995510245 | 0.394657500376154 | 0.00343873179254624 | 0.0195424817819127 |
| Q15836 | Q15836 | VAMP3_HUMAN | Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3) | VAMP3 | calcium-ion regulated exocytosis [GO:0017156]; cellular response to type II interferon [GO:0071346]; exocytosis [GO:0006887]; Golgi to plasma membrane protein transport [GO:0043001]; membrane fusion [GO:0061025]; negative regulation of secretion by cell [GO:1903531]; positive regulation of receptor recycling [GO:0001921]; protein-containing complex assembly [GO:0065003]; retrograde transport, endosome to Golgi [GO:0042147]; SNARE complex assembly [GO:0035493]; substrate adhesion-dependent cell spreading [GO:0034446]; vesicle docking involved in exocytosis [GO:0006904]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192] | cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; secretory granule [GO:0030141]; SNARE complex [GO:0031201]; synapse [GO:0045202]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133] | SNAP receptor activity [GO:0005484]; syntaxin-1 binding [GO:0017075] | 295796.875351464 | -0.985221742776515 | 0.0035037418615836 | 0.0198919853584496 |
| Q6P1N0 | Q6P1N0 | C2D1A_HUMAN | Coiled-coil and C2 domain-containing protein 1A (Akt kinase-interacting protein 1) (Five prime repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B-activating protein 023N) | CC2D1A | apical dendrite arborization [GO:0150023]; endosome organization [GO:0007032]; negative regulation of snRNA transcription by RNA polymerase II [GO:1905381]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of transcription by RNA polymerase II [GO:0006357] | centrosome [GO:0005813]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | cadherin binding [GO:0045296]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] | 8040.402117959025 | -0.39037815677737 | 0.00354036828214706 | 0.0200798064931384 |
| Q9GZQ3 | Q9GZQ3 | COMD5_HUMAN | COMM domain-containing protein 5 (Hypertension-related calcium-regulated gene protein) (HCaRG) | COMMD5 | cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | 9628.973193233243 | -0.607926753054685 | 0.00357485513118942 | 0.0202551291733192 | ||
| Q96Q05 | Q96Q05 | TPPC9_HUMAN | Trafficking protein particle complex subunit 9 (NIK- and IKBKB-binding protein) (Tularik gene 1 protein) | TRAPPC9 | cerebral cortex development [GO:0021987]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; neuron differentiation [GO:0030182]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; trans-Golgi network [GO:0005802]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071] | 4474.559698835315 | -1.28256164460135 | 0.00359072515863714 | 0.0203247240248132 | |
| Q5VW36 | Q5VW36 | FOCAD_HUMAN | Focadhesin | FOCAD | regulation of post-transcriptional gene silencing [GO:0060147] | cytosol [GO:0005829]; focal adhesion [GO:0005925] | 5642.261739157046 | -0.491102060687428 | 0.003594938822394 | 0.0203282668340164 | |
| Q7Z4R8 | Q7Z4R8 | CF120_HUMAN | UPF0669 protein C6orf120 | C6orf120 | apoptotic process [GO:0006915] | azurophil granule lumen [GO:0035578]; extracellular region [GO:0005576] | 17118.5552785086 | 0.640050278978506 | 0.00362909973327805 | 0.0204398400484626 | |
| O95801 | O95801 | TTC4_HUMAN | Tetratricopeptide repeat protein 4 (TPR repeat protein 4) | TTC4 | defense response to virus [GO:0051607]; innate immune response [GO:0045087]; protein folding [GO:0006457] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879] | 11692.7732224856 | 0.334888957680637 | 0.00366522691752015 | 0.0206228160026506 |
| Q9NS86 | Q9NS86 | LANC2_HUMAN | LanC-like protein 2 (Testis-specific adriamycin sensitivity protein) | LANCL2 | carbohydrate metabolic process [GO:0005975]; negative regulation of DNA-templated transcription [GO:0045892]; peptide modification [GO:0031179]; positive regulation of abscisic acid-activated signaling pathway [GO:0009789] | cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | ATP binding [GO:0005524]; GTP binding [GO:0005525]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314] | 8243.09112766556 | -0.466623700975907 | 0.00369822691537547 | 0.0207878508953546 |
| P20290 | P20290 | BTF3_HUMAN | Transcription factor BTF3 (Nascent polypeptide-associated complex subunit beta) (NAC-beta) (RNA polymerase B transcription factor 3) | BTF3 | in utero embryonic development [GO:0001701]; negative regulation of protein localization to endoplasmic reticulum [GO:1905551]; protein transport [GO:0015031] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nascent polypeptide-associated complex [GO:0005854]; nucleus [GO:0005634] | RNA binding [GO:0003723] | 88863.85560687775 | 0.453085935858269 | 0.00370206866848513 | 0.0207888216805122 |
| P04439 | P04439 | HLAA_HUMAN | HLA class I histocompatibility antigen, A alpha chain (Human leukocyte antigen A) (HLA-A) | HLA-A | antibacterial humoral response [GO:0019731]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent [GO:0002485]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; CD8-positive, alpha-beta T cell activation [GO:0036037]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; immune response [GO:0006955]; innate immune response [GO:0045087]; peptide antigen assembly with MHC class I protein complex [GO:0002502]; positive regulation of CD8-positive, alpha-beta T cell activation [GO:2001187]; positive regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000566]; positive regulation of memory T cell activation [GO:2000568]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of type II interferon production [GO:0032729]; protection from natural killer cell mediated cytotoxicity [GO:0042270]; T cell mediated cytotoxicity [GO:0001913]; T cell mediated cytotoxicity directed against tumor cell target [GO:0002419]; T cell receptor signaling pathway [GO:0050852] | cell surface [GO:0009986]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; MHC class I peptide loading complex [GO:0042824]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] | beta-2-microglobulin binding [GO:0030881]; CD8 receptor binding [GO:0042610]; peptide antigen binding [GO:0042605]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102]; T cell receptor binding [GO:0042608]; TAP binding [GO:0046977]; TAP complex binding [GO:0062061] | 36213.89771508175 | 0.601796859511332 | 0.00375391856161774 | 0.0210591114555704 |
| Q15370 | Q15370 | ELOB_HUMAN | Elongin-B (EloB) (Elongin 18 kDa subunit) (RNA polymerase II transcription factor SIII subunit B) (SIII p18) (Transcription elongation factor B polypeptide 2) | ELOB | positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; protein-containing complex assembly [GO:0065003]; target-directed miRNA degradation [GO:0140958]; transcription elongation by RNA polymerase II [GO:0006368]; transcription initiation at RNA polymerase II promoter [GO:0006367] | Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul5-RING ubiquitin ligase complex [GO:0031466]; cytosol [GO:0005829]; elongin complex [GO:0070449]; nucleoplasm [GO:0005654]; VCB complex [GO:0030891] | transcription corepressor binding [GO:0001222]; ubiquitin protein ligase binding [GO:0031625] | 65063.8434495918 | 0.350584782144182 | 0.00376115651827751 | 0.0210788455317115 |
| Q9Y490 | Q9Y490 | TLN1_HUMAN | Talin-1 | TLN1 | cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; cell-substrate junction assembly [GO:0007044]; cortical actin cytoskeleton organization [GO:0030866]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; platelet aggregation [GO:0070527]; regulation of focal adhesion assembly [GO:0051893] | adherens junction [GO:0005912]; cell surface [GO:0009986]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587] | actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; integrin binding [GO:0005178]; LIM domain binding [GO:0030274]; phosphatidylinositol binding [GO:0035091]; phosphatidylserine binding [GO:0001786]; structural constituent of cytoskeleton [GO:0005200]; vinculin binding [GO:0017166] | 138236.952777127 | -0.236512453664993 | 0.00378084453649974 | 0.0211473495990202 |
| Q13247 | Q13247 | SRSF6_HUMAN | Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6) | SRSF6 | alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA splice site recognition [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of keratinocyte differentiation [GO:0045617]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of type B pancreatic cell apoptotic process [GO:2000675]; positive regulation of epithelial cell proliferation involved in lung morphogenesis [GO:0060501]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of keratinocyte proliferation [GO:0010837]; regulation of wound healing [GO:0061041]; response to insulin [GO:0032868] | nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] | pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723] | 49560.4095855411 | 0.408471739107183 | 0.00378586635278545 | 0.0211545549850911 |
| P05026 | P05026 | AT1B1_HUMAN | Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1) | ATP1B1 | ATP metabolic process [GO:0046034]; cardiac muscle contraction [GO:0060048]; cell adhesion [GO:0007155]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; innate immune response [GO:0045087]; intracellular calcium ion homeostasis [GO:0006874]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; membrane repolarization [GO:0086009]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; monoatomic cation transmembrane transport [GO:0098655]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of calcium:sodium antiporter activity [GO:1903281]; positive regulation of P-type sodium:potassium-exchanging transporter activity [GO:1903408]; positive regulation of potassium ion import across plasma membrane [GO:1903288]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of sodium ion export across plasma membrane [GO:1903278]; potassium ion import across plasma membrane [GO:1990573]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; protein transport into plasma membrane raft [GO:0044861]; proton transmembrane transport [GO:1902600]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of gene expression [GO:0010468]; relaxation of cardiac muscle [GO:0055119]; sodium ion export across plasma membrane [GO:0036376]; sodium ion transmembrane transport [GO:0035725] | apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; intercalated disc [GO:0014704]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; sodium:potassium-exchanging ATPase complex [GO:0005890]; sperm flagellum [GO:0036126]; T-tubule [GO:0030315] | ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; MHC class II protein complex binding [GO:0023026]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674] | 8756.349476781226 | 0.76087302655457 | 0.00379157555591956 | 0.0211655833495963 |
| Q16718 | Q16718 | NDUA5_HUMAN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (Complex I subunit B13) (Complex I-13kD-B) (CI-13kD-B) (NADH-ubiquinone oxidoreductase 13 kDa-B subunit) | NDUFA5 | aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; respiratory electron transport chain [GO:0022904] | mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747] | NADH dehydrogenase (ubiquinone) activity [GO:0008137] | 7750.113215720415 | -1.59336191297845 | 0.00382081308561849 | 0.0213078021093645 |
| P62318 | P62318 | SMD3_HUMAN | Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3) | SNRPD3 | 7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; protein methylation [GO:0006479]; RNA splicing [GO:0008380]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241] | catalytic step 2 spliceosome [GO:0071013]; commitment complex [GO:0000243]; cytosol [GO:0005829]; methylosome [GO:0034709]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; precatalytic spliceosome [GO:0071011]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; spliceosomal tri-snRNP complex [GO:0097526]; telomerase holoenzyme complex [GO:0005697]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; U7 snRNP [GO:0005683] | enzyme binding [GO:0019899]; histone pre-mRNA DCP binding [GO:0071208]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]; U1 snRNP binding [GO:1990446]; U7 snRNA binding [GO:0071209] | 31674.0909922758 | -0.910206400454002 | 0.00382606840610268 | 0.0213161293893587 |
| Q6P2Q9 | Q6P2Q9 | PRP8_HUMAN | Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220) | PRPF8 | cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal tri-snRNP complex assembly [GO:0000244] | catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682] | K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; U1 snRNA binding [GO:0030619]; U2 snRNA binding [GO:0030620]; U5 snRNA binding [GO:0030623]; U6 snRNA binding [GO:0017070] | 10093.37205394045 | -0.319584036090289 | 0.00385550280871198 | 0.0214590166150904 |
| P37268 | P37268 | FDFT_HUMAN | Squalene synthase (SQS) (SS) (EC 2.5.1.21) (FPP:FPP farnesyltransferase) (Farnesyl-diphosphate farnesyltransferase) (Farnesyl-diphosphate farnesyltransferase 1) | FDFT1 | cholesterol biosynthetic process [GO:0006695]; ergosterol biosynthetic process [GO:0006696]; farnesyl diphosphate metabolic process [GO:0045338]; steroid biosynthetic process [GO:0006694] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] | farnesyl-diphosphate farnesyltransferase activity [GO:0004310]; farnesyltranstransferase activity [GO:0004311]; metal ion binding [GO:0046872]; squalene synthase activity [GO:0051996] | 14498.22534831395 | 0.369104870508839 | 0.00391451210911981 | 0.021766070275047 |
| O95810 | O95810 | CAVN2_HUMAN | Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein) | CAVIN2 | plasma membrane tubulation [GO:0097320] | caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] | phosphatidylserine binding [GO:0001786]; phospholipid binding [GO:0005543]; protein kinase C binding [GO:0005080] | 67158.0886151299 | 0.306827978679395 | 0.00393430113381651 | 0.0218118886733898 |
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| Q15149 | |||||||||
| Q99715 | |||||||||
| P02452 | |||||||||
| P02751 | |||||||||
| P98160 | |||||||||
| P08123 | |||||||||
| P02461 | |||||||||
| P07996 | |||||||||
| Q8WWI1 | |||||||||
| P05997 | |||||||||
| P20908 | |||||||||
| Q8WUJ3 | |||||||||
| P21333 | |||||||||
| O75369 | |||||||||
| Q15063 | |||||||||
| P02786 | |||||||||
| Q12884 | |||||||||
| P12814 | |||||||||
| Q9UDY2 | |||||||||
| Q14195 | |||||||||
| Q02952 | |||||||||
| Q9NZM1 | |||||||||
| P35579 | |||||||||
| P35354 | |||||||||
| P47895 | |||||||||
| Q09666 | |||||||||
| P11717 | |||||||||
| Q14112 | |||||||||
| Q13620 | |||||||||
| P43490 | |||||||||
| Q3SY69 | |||||||||
| P17812 | |||||||||
| P21980 | |||||||||
| Q16647 | |||||||||
| P01024 | |||||||||
| Q5SW79 | |||||||||
| P06396 | |||||||||
| P12111 | |||||||||
| P35221 | |||||||||
| P12429 | |||||||||
| P78559 | |||||||||
| Q76M96 | |||||||||
| Q16881 | |||||||||
| P07093 | |||||||||
| P27487 | |||||||||
| P15144 | |||||||||
| Q9H5V8 | |||||||||
| P08729 | |||||||||
| Q04828 | |||||||||
| O94925 | |||||||||
| P08473 | |||||||||
| Q8IVL5 | |||||||||
| P35442 | |||||||||
| O60716 | |||||||||
| P08253 | |||||||||
| Q16822 | |||||||||
| Q9UJ72 | |||||||||
| Q9Y617 | |||||||||
| Q8WX93 | |||||||||
| Q32MZ4 | |||||||||
| Q6P179 | |||||||||
| P48681 | |||||||||
| O95340 | |||||||||
| P21580 | |||||||||
| Q00341 | |||||||||
| P49748 | |||||||||
| O43854 | |||||||||
| P07942 | |||||||||
| Q96KC8 | |||||||||
| Q96PD2 | |||||||||
| Q13418 | |||||||||
| Q7Z7G0 | |||||||||
| Q04446 | |||||||||
| P19022 | |||||||||
| O00469 | |||||||||
| Q8WUF5 | |||||||||
| Q14767 | |||||||||
| Q13308 | |||||||||
| P46940 | |||||||||
| Q9NZ08 | |||||||||
| O60488 | |||||||||
| P35222 | |||||||||
| Q9H4M9 | |||||||||
| Q9NZU5 | |||||||||
| Q15113 | |||||||||
| O94808 | |||||||||
| Q9UI42 | |||||||||
| Q15417 | |||||||||
| Q15582 | |||||||||
| P35908 | |||||||||
| P00750 | |||||||||
| Q9UHD8 | |||||||||
| P11047 | |||||||||
| Q8N6G6 | |||||||||
| Q05682 | |||||||||
| P17342 | |||||||||
| Q16363 | |||||||||
| Q9NR12 | |||||||||
| P05362 | |||||||||
| P00966 | |||||||||
| P05120 | |||||||||
| P15121 | |||||||||
| P04179 | |||||||||
| Q15785 | |||||||||
| O60271 | |||||||||
| Q9Y6N5 | |||||||||
| Q9P0V9 | |||||||||
| Q8IVF2 | |||||||||
| P01584 | |||||||||
| Q96AQ6 | |||||||||
| P54289 | |||||||||
| P13667 | |||||||||
| Q96HE7 | |||||||||
| P21810 | |||||||||
| Q16790 | |||||||||
| P23396 | |||||||||
| P01130 | |||||||||
| P51812 | |||||||||
| O95490 | |||||||||
| Q16222 | |||||||||
| Q7Z4N8 | |||||||||
| P08133 | |||||||||
| Q08431 | |||||||||
| P23142 | |||||||||
| Q01581 | |||||||||
| P10915 | |||||||||
| O75976 | |||||||||
| P23219 | |||||||||
| Q8IXK2 | |||||||||
| Q07954 | |||||||||
| P50225 | |||||||||
| P11413 | |||||||||
| Q5SSJ5 | |||||||||
| Q6PCE3 | |||||||||
| P05091 | |||||||||
| P49419 | |||||||||
| P41252 | |||||||||
| P50281 | |||||||||
| Q13618 | |||||||||
| Q00653 | |||||||||
| Q9BZG1 | |||||||||
| P11142 | |||||||||
| P63010 | |||||||||
| Q9UBG0 | |||||||||
| Q5GLZ8 | |||||||||
| P21266 | |||||||||
| Q9BS40 | |||||||||
| P35232 | |||||||||
| Q86VP6 | |||||||||
| P09601 | |||||||||
| Q8N8S7 | |||||||||
| Q16851 | |||||||||
| P28845 | |||||||||
| P26640 | |||||||||
| Q92626 | |||||||||
| P07686 | |||||||||
| P01583 | |||||||||
| Q96HH9 | |||||||||
| P48506 | |||||||||
| P47712 | |||||||||
| Q14314 | |||||||||
| Q53FA7 | |||||||||
| Q9H425 | |||||||||
| Q14204 | |||||||||
| P01033 | |||||||||
| Q92616 | |||||||||
| Q16666 | |||||||||
| Q99623 | |||||||||
| P23381 | |||||||||
| Q8N6Y2 | |||||||||
| P98155 | |||||||||
| P46977 | |||||||||
| Q86SQ0 | |||||||||
| Q70E73 | |||||||||
| Q6VY07 | |||||||||
| P41250 | |||||||||
| P56945 | |||||||||
| P29279 | |||||||||
| Q96C19 | |||||||||
| Q9UPN3 | |||||||||
| P26022 | |||||||||
| P00492 | |||||||||
| Q9BXS4 | |||||||||
| P50452 | |||||||||
| P05783 | |||||||||
| Q14980 | |||||||||
| Q9UBX5 | |||||||||
| O75094 | |||||||||
| Q06323 | |||||||||
| O14672 | |||||||||
| O00339 | |||||||||
| P52209 | |||||||||
| Q00325 | |||||||||
| P30044 | |||||||||
| P30740 | |||||||||
| P46734 | |||||||||
| P48307 | |||||||||
| P08648 | |||||||||
| O43175 | |||||||||
| O00116 |
