Selected Cell
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stat_data__min_2_Peptides
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| Q5SNT2 | Q5SNT2 | TM201_HUMAN | Transmembrane protein 201 (Spindle-associated membrane protein 1) | TMEM201 | centrosome localization [GO:0051642]; fibroblast migration [GO:0010761]; nuclear envelope organization [GO:0006998]; nuclear migration along microtubule [GO:0030473]; protein localization to nuclear envelope [GO:0090435] | cytoplasm [GO:0005737]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; spindle pole [GO:0000922] | actin filament binding [GO:0051015]; lamin binding [GO:0005521] | 9478.847844977605 | -0.0299777812192482 | 0.873737933408586 | 1 |
| Q6NUQ4 | Q6NUQ4 | TM214_HUMAN | Transmembrane protein 214 | TMEM214 | apoptotic process [GO:0006915] | cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794] | 23956.5103627722 | 0.0663644683957623 | 0.855550581384928 | 1 | |
| Q96A57 | Q96A57 | TM230_HUMAN | Transmembrane protein 230 | TMEM230 | synaptic vesicle transport [GO:0048489] | autophagosome [GO:0005776]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; late endosome [GO:0005770]; membrane [GO:0016020]; recycling endosome [GO:0055037]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802] | 43011.5766534384 | -0.0243826707505708 | 0.967227719884473 | 1 | |
| Q96Q45 | Q96Q45 | TM237_HUMAN | Transmembrane protein 237 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein) | TMEM237 | cilium assembly [GO:0060271]; regulation of Wnt signaling pathway [GO:0030111] | ciliary transition zone [GO:0035869]; cone photoreceptor outer segment [GO:0120199]; membrane [GO:0016020]; photoreceptor connecting cilium [GO:0032391]; rod photoreceptor outer segment [GO:0120200] | 11991.588645441901 | -0.0706882398654748 | 0.77983768733802 | 1 | |
| Q9H330 | Q9H330 | TM245_HUMAN | Transmembrane protein 245 (Protein CG-2) | TMEM245 | membrane [GO:0016020] | 14287.22559907325 | 0.0576831427585961 | 0.822163484603804 | 1 | ||
| Q2T9K0 | Q2T9K0 | TMM44_HUMAN | Transmembrane protein 44 | TMEM44 | membrane [GO:0016020] | 1382.134301396525 | -0.0150008311447848 | 0.870152020798582 | 1 | ||
| Q6PI78 | Q6PI78 | TMM65_HUMAN | Transmembrane protein 65 | TMEM65 | cardiac conduction [GO:0061337]; cardiac ventricle development [GO:0003231]; regulation of cardiac conduction [GO:1903779] | intercalated disc [GO:0014704]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] | 11361.80209574625 | -0.065622381904484 | 0.788050137793521 | 1 | |
| Q9NYL9 | Q9NYL9 | TMOD3_HUMAN | Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod) | TMOD3 | actin filament organization [GO:0007015]; erythrocyte development [GO:0048821]; mitotic cell cycle phase transition [GO:0044772]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694]; positive regulation of mitotic cell cycle phase transition [GO:1901992] | adherens junction [GO:0005912]; cytoskeleton [GO:0005856]; myofibril [GO:0030016]; striated muscle thin filament [GO:0005865] | actin binding [GO:0003779]; cadherin binding involved in cell-cell adhesion [GO:0098641]; tropomyosin binding [GO:0005523] | 71967.98594605201 | 0.0959652083536481 | 0.798682233686089 | 1 |
| P42166 | P42166 | LAP2A_HUMAN | Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | TMPO | chromatin [GO:0000785]; nuclear envelope [GO:0005635]; nucleus [GO:0005634] | cadherin binding [GO:0045296]; DNA binding [GO:0003677]; lamin binding [GO:0005521] | 26333.01932849565 | 0.117103729066081 | 0.682023733028038 | 1 | |
| P62328 | P62328 | TYB4_HUMAN | Thymosin beta-4 (T beta-4) (Fx) [Cleaved into: Hemoregulatory peptide AcSDKP (Ac-Ser-Asp-Lys-Pro) (N-acetyl-SDKP) (AcSDKP) (Seraspenide)] | TMSB4X | actin filament organization [GO:0007015]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of inflammatory response [GO:0050728]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of proton-transporting ATP synthase activity, rotational mechanism [GO:1905273]; regulation of cell migration [GO:0030334]; sequestering of actin monomers [GO:0042989]; tumor necrosis factor-mediated signaling pathway [GO:0033209] | cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093] | actin monomer binding [GO:0003785]; enzyme binding [GO:0019899]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723] | 57008.878296645446 | 0.281928925219993 | 0.735762106187433 | 1 |
| Q6ZXV5 | Q6ZXV5 | TMTC3_HUMAN | Protein O-mannosyl-transferase TMTC3 (EC 2.4.1.109) (Protein SMILE) (Transmembrane O-mannosyltransferase targeting cadherins 3) (Transmembrane and tetratricopeptide repeat-containing 3) | TMTC3 | positive regulation of proteasomal protein catabolic process [GO:1901800]; protein O-linked mannosylation [GO:0035269]; response to endoplasmic reticulum stress [GO:0034976] | endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] | dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030] | 10499.2365794591 | -0.0220934080332487 | 0.999900287199205 | 1 |
| Q96JJ7 | Q96JJ7 | TMX3_HUMAN | Protein disulfide-isomerase TMX3 (EC 5.3.4.1) (Thioredoxin domain-containing protein 10) (Thioredoxin-related transmembrane protein 3) | TMX3 | cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092] | protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035] | 56434.686811735344 | 0.0698595867482089 | 0.980912141687796 | 1 | |
| Q03169 | Q03169 | TNAP2_HUMAN | Tumor necrosis factor alpha-induced protein 2 (TNF alpha-induced protein 2) (Primary response gene B94 protein) | TNFAIP2 | angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; exocyst localization [GO:0051601]; exocytosis [GO:0006887] | exocyst [GO:0000145]; extracellular space [GO:0005615] | SNARE binding [GO:0000149] | 3937.7555272007203 | 0.0227283615622178 | 0.996760577545299 | 1 |
| O00300 | O00300 | TR11B_HUMAN | Tumor necrosis factor receptor superfamily member 11B (Osteoclastogenesis inhibitory factor) (Osteoprotegerin) | TNFRSF11B | apoptotic process [GO:0006915]; extracellular matrix organization [GO:0030198]; negative regulation of bone resorption [GO:0045779]; negative regulation of odontogenesis of dentin-containing tooth [GO:0042489]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; response to arsenic-containing substance [GO:0046685]; response to estrogen [GO:0043627]; response to magnesium ion [GO:0032026]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; skeletal system development [GO:0001501] | extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] | cytokine activity [GO:0005125]; heparan sulfate binding [GO:1904399]; signaling receptor activity [GO:0038023] | 5260.571897780181 | 0.00109319964061842 | 0.973578685362322 | 1 |
| Q15025 | Q15025 | TNIP1_HUMAN | TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN-1) (HIV-1 Nef-interacting protein) (Nef-associated factor 1) (Naf1) (Nip40-1) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) | TNIP1 | cellular response to lipopolysaccharide [GO:0071222]; defense response [GO:0006952]; glycoprotein biosynthetic process [GO:0009101]; inflammatory response [GO:0006954]; leukocyte cell-cell adhesion [GO:0007159]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of viral genome replication [GO:0045071]; positive regulation of inflammatory response [GO:0050729]; positive regulation of protein deubiquitination [GO:1903003]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; translation [GO:0006412] | cytosol [GO:0005829]; nucleoplasm [GO:0005654] | identical protein binding [GO:0042802]; mitogen-activated protein kinase binding [GO:0051019] | 4977.406574843955 | -0.0403141921431523 | 0.999705019806468 | 1 |
| Q9C0C2 | Q9C0C2 | TB182_HUMAN | 182 kDa tankyrase-1-binding protein | TNKS1BP1 | cellular response to ionizing radiation [GO:0071479]; double-strand break repair [GO:0006302]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein autophosphorylation [GO:0031954]; telomere maintenance via telomerase [GO:0007004] | adherens junction [GO:0005912]; CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | ankyrin repeat binding [GO:0071532]; cadherin binding [GO:0045296]; enzyme binding [GO:0019899]; protein-containing complex binding [GO:0044877] | 37405.06006533255 | 0.00510743293644072 | 1 | 1 |
| Q92973 | Q92973 | TNPO1_HUMAN | Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP) | TNPO1 | protein import into nucleus [GO:0006606] | cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] | nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267] | 21850.557075993347 | -0.0440494460891178 | 0.999763777783305 | 1 |
| Q8NDV7 | Q8NDV7 | TNR6A_HUMAN | Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) | TNRC6A | cellular response to starvation [GO:0009267]; endoderm development [GO:0007492]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213] | cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; RISC complex [GO:0016442] | RNA binding [GO:0003723] | 4725.4766894350905 | 0.190959636542102 | 0.947040634279572 | 1 |
| Q9UPQ9 | Q9UPQ9 | TNR6B_HUMAN | Trinucleotide repeat-containing gene 6B protein | TNRC6B | miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; regulatory ncRNA-mediated gene silencing [GO:0031047] | cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932] | RNA binding [GO:0003723] | 4297.65527918462 | 8.71156897967909E-4 | 0.999999968173617 | 1 |
| Q68CZ2 | Q68CZ2 | TENS3_HUMAN | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | TNS3 | dephosphorylation [GO:0016311] | cell projection [GO:0042995]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; podosome [GO:0002102] | phosphoprotein phosphatase activity [GO:0004721] | 6805.279015377089 | 0.00322563249194818 | 0.999999994290791 | 1 |
| Q6ZVM7 | Q6ZVM7 | TM1L2_HUMAN | TOM1-like protein 2 (Target of Myb-like protein 2) | TOM1L2 | negative regulation of mitotic nuclear division [GO:0045839]; protein transport [GO:0015031]; signal transduction [GO:0007165] | endosome [GO:0005768]; extracellular exosome [GO:0070062]; membrane [GO:0016020] | clathrin binding [GO:0030276]; phosphatidylinositol binding [GO:0035091]; protein kinase binding [GO:0019901]; ubiquitin binding [GO:0043130] | 16804.4711597186 | -0.0164290209044464 | 0.999992712971762 | 1 |
| Q9NXH8 | Q9NXH8 | TOR4A_HUMAN | Torsin-4A (Torsin family 4 member A) | TOR4A | endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; platelet alpha granule lumen [GO:0031093] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] | 9134.060795486646 | -0.0131372928691724 | 0.999985934895521 | 1 | |
| Q13625 | Q13625 | ASPP2_HUMAN | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | TP53BP2 | cell cycle [GO:0007049]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of cell cycle [GO:0045786]; positive regulation of execution phase of apoptosis [GO:1900119]; signal transduction [GO:0007165] | cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] | identical protein binding [GO:0042802]; NF-kappaB binding [GO:0051059]; p53 binding [GO:0002039]; protein homodimerization activity [GO:0042803]; SH3 domain binding [GO:0017124] | 5343.702538129401 | 0.0481606819881968 | 0.988833598668425 | 1 |
| Q96S44 | Q96S44 | PRPK_HUMAN | EKC/KEOPS complex subunit TP53RK (EC 3.6.-.-) (Atypical serine/threonine protein kinase TP53RK) (Nori-2) (TP53-regulating kinase) (EC 2.7.11.1) (p53-related protein kinase) | TP53RK | protein phosphorylation [GO:0006468]; regulation of signal transduction by p53 class mediator [GO:1901796]; tRNA processing [GO:0008033]; tRNA threonylcarbamoyladenosine metabolic process [GO:0070525] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; EKC/KEOPS complex [GO:0000408]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; p53 binding [GO:0002039]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | 17279.00675939115 | -0.0566122673925244 | 0.957052358553152 | 1 |
| Q16890 | Q16890 | TPD53_HUMAN | Tumor protein D53 (hD53) (Tumor protein D52-like 1) | TPD52L1 | G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAP kinase activity [GO:0043406] | cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471] | identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] | 8987.59130624422 | -0.132680211868822 | 0.780844852361654 | 1 |
| P67936 | P67936 | TPM4_HUMAN | Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4) | TPM4 | actin filament organization [GO:0007015]; muscle contraction [GO:0006936]; osteoblast differentiation [GO:0001649]; platelet formation [GO:0030220] | actin filament [GO:0005884]; cortical cytoskeleton [GO:0030863]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; muscle thin filament tropomyosin [GO:0005862]; podosome [GO:0002102]; stress fiber [GO:0001725] | actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; structural constituent of muscle [GO:0008307] | 243735.57500135648 | 0.0863899516025481 | 0.999453405218267 | 1 |
| O14773 | O14773 | TPP1_HUMAN | Tripeptidyl-peptidase 1 (TPP-1) (EC 3.4.14.9) (Cell growth-inhibiting gene 1 protein) (Lysosomal pepstatin-insensitive protease) (LPIC) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase I) (TPP-I) | TPP1 | bone resorption [GO:0045453]; central nervous system development [GO:0007417]; epithelial cell differentiation [GO:0030855]; lipid metabolic process [GO:0006629]; lysosomal protein catabolic process [GO:1905146]; lysosome organization [GO:0007040]; nervous system development [GO:0007399]; neuromuscular process controlling balance [GO:0050885]; peptide catabolic process [GO:0043171]; protein catabolic process [GO:0030163]; protein localization to chromosome, telomeric region [GO:0070198]; proteolysis [GO:0006508] | extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane raft [GO:0045121]; recycling endosome [GO:0055037] | endopeptidase activity [GO:0004175]; lysophosphatidic acid binding [GO:0035727]; metal ion binding [GO:0046872]; peptidase activity [GO:0008233]; peptide binding [GO:0042277]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; sulfatide binding [GO:0120146]; tripeptidyl-peptidase activity [GO:0008240] | 66133.80335092725 | 0.12297561269549 | 0.831460570541022 | 1 |
| P29144 | P29144 | TPP2_HUMAN | Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II) | TPP2 | intracellular amino acid homeostasis [GO:0080144]; protein polyubiquitination [GO:0000209]; proteolysis [GO:0006508] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654] | aminopeptidase activity [GO:0004177]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252]; tripeptidyl-peptidase activity [GO:0008240] | 16563.08753211565 | -0.0921139012157461 | 0.990815446522178 | 1 |
| P12270 | P12270 | TPR_HUMAN | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | TPR | cell division [GO:0051301]; cellular response to heat [GO:0034605]; cellular response to interferon-alpha [GO:0035457]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mRNA export from nucleus [GO:0006406]; mRNA export from nucleus in response to heat stress [GO:0031990]; negative regulation of RNA export from nucleus [GO:0046832]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translational initiation [GO:0045947]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; positive regulation of heterochromatin formation [GO:0031453]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein import into nucleus [GO:0042307]; protein import into nucleus [GO:0006606]; regulation of mitotic sister chromatid separation [GO:0010965]; regulation of mitotic spindle assembly [GO:1901673]; regulation of protein localization [GO:0032880]; response to epidermal growth factor [GO:0070849]; RNA export from nucleus [GO:0006405]; RNA import into nucleus [GO:0006404] | cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; kinetochore [GO:0000776]; mitotic spindle [GO:0072686]; nuclear envelope [GO:0005635]; nuclear inclusion body [GO:0042405]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | chromatin binding [GO:0003682]; dynein complex binding [GO:0070840]; heat shock protein binding [GO:0031072]; mitogen-activated protein kinase binding [GO:0051019]; mRNA binding [GO:0003729]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; structural constituent of nuclear pore [GO:0017056]; tubulin binding [GO:0015631] | 17749.210810790748 | -0.08518568796893 | 0.873940880396181 | 1 |
| Q13114 | Q13114 | TRAF3_HUMAN | TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3) | TRAF3 | apoptotic process [GO:0006915]; defense response to virus [GO:0051607]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of type I interferon production [GO:0032481]; protein K63-linked ubiquitination [GO:0070534]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of cytokine production [GO:0001817]; regulation of defense response to virus [GO:0050688]; regulation of interferon-beta production [GO:0032648]; regulation of proteolysis [GO:0030162]; signal transduction [GO:0007165]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; type I interferon-mediated signaling pathway [GO:0060337] | CD40 receptor complex [GO:0035631]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; mitochondrion [GO:0005739]; serine/threonine protein kinase complex [GO:1902554]; ubiquitin ligase complex [GO:0000151] | identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] | 6358.010245610585 | 0.248177055962442 | 0.987173798409418 | 1 |
| P48553 | P48553 | TPC10_HUMAN | Trafficking protein particle complex subunit 10 (Epilepsy holoprosencephaly candidate 1 protein) (EHOC-1) (Protein GT334) (Trafficking protein particle complex subunit TMEM1) (Transport protein particle subunit TMEM1) (TRAPP subunit TMEM1) | TRAPPC10 | early endosome to Golgi transport [GO:0034498]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071] | 2873.1740158385446 | 0.172126550025461 | 0.881163510133336 | 1 | |
| Q7Z392 | Q7Z392 | TPC11_HUMAN | Trafficking protein particle complex subunit 11 | TRAPPC11 | constitutive secretory pathway [GO:0045054]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; regulation of protein complex stability [GO:0061635]; vesicle tethering [GO:0099022] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; TRAPP complex [GO:0030008]; TRAPPIII protein complex [GO:1990072] | 4772.59095967165 | -0.159650289173785 | 0.847788498575504 | 1 | |
| Q8WVT3 | Q8WVT3 | TPC12_HUMAN | Trafficking protein particle complex subunit 12 (Tetratricopeptide repeat protein 15) (TPR repeat protein 15) (TTC-15) (Trafficking of membranes and mitosis) | TRAPPC12 | COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; metaphase chromosome alignment [GO:0051310]; positive regulation of protein localization to kinetochore [GO:1905342]; regulation of kinetochore assembly [GO:0090234]; vesicle tethering [GO:0099022] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TRAPP complex [GO:0030008]; TRAPPIII protein complex [GO:1990072] | 9478.778111600725 | 0.122997624318102 | 0.6640493371629 | 1 | |
| P0DI81;P0DI82 | P0DI81 | TPC2A_HUMAN | Trafficking protein particle complex subunit 2 (Sedlin) | TRAPPC2 | COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; skeletal system development [GO:0001501]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072] | transmembrane transporter binding [GO:0044325] | 11766.478521213001 | 0.0651797941534668 | 0.834670890073229 | 1 |
| O00635 | O00635 | TRI38_HUMAN | E3 ubiquitin-protein ligase TRIM38 (EC 2.3.2.27) (RING finger protein 15) (Tripartite motif-containing protein 38) (Zinc finger protein RoRet) | TRIM38 | innate immune response [GO:0045087]; negative regulation of defense response to virus [GO:0050687]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of viral entry into host cell [GO:0046598]; positive regulation of viral genome replication [GO:0045070]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; protein sumoylation [GO:0016925]; regulation of interferon-beta production [GO:0032648]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] | protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] | 10342.326487535225 | -0.0773751610572858 | 0.923774185837505 | 1 |
| Q9C035 | Q9C035 | TRIM5_HUMAN | Tripartite motif-containing protein 5 (EC 2.3.2.27) (RING finger protein 88) (RING-type E3 ubiquitin transferase TRIM5) | TRIM5 | activation of innate immune response [GO:0002218]; autophagy [GO:0006914]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; regulation of lipopolysaccharide-mediated signaling pathway [GO:0031664]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]; suppression of viral release by host [GO:0044790] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932] | identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] | 2862.244297727085 | 0.0629090158318255 | 0.926572965556045 | 1 |
| Q9BRZ2 | Q9BRZ2 | TRI56_HUMAN | E3 ubiquitin-protein ligase TRIM56 (EC 2.3.2.27) (RING finger protein 109) (Tripartite motif-containing protein 56) | TRIM56 | defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; regulation of type I interferon production [GO:0032479]; response to type I interferon [GO:0034340] | cytoplasm [GO:0005737]; cytosol [GO:0005829] | RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] | 5834.27244186554 | -0.112079534829253 | 0.7803652596253 | 1 |
| Q15642 | Q15642 | CIP4_HUMAN | Cdc42-interacting protein 4 (Protein Felic) (Salt tolerant protein) (hSTP) (Thyroid receptor-interacting protein 10) (TR-interacting protein 10) (TRIP-10) | TRIP10 | actin cytoskeleton organization [GO:0030036]; cell communication [GO:0007154]; endocytosis [GO:0006897]; signal transduction [GO:0007165] | cell cortex [GO:0005938]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891] | identical protein binding [GO:0042802]; lipid binding [GO:0008289] | 22101.57520983815 | -0.0199239671933204 | 0.999685435086211 | 1 |
| Q14669 | Q14669 | TRIPC_HUMAN | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | TRIP12 | DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; heterochromatin boundary formation [GO:0033696]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of embryonic development [GO:0045995]; ubiquitin-dependent protein catabolic process [GO:0006511] | cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | nuclear thyroid hormone receptor binding [GO:0046966]; ubiquitin protein ligase activity [GO:0061630] | 5710.889782471845 | -0.0109085448045681 | 0.99999999973254 | 1 |
| Q15650 | Q15650 | TRIP4_HUMAN | Activating signal cointegrator 1 (ASC-1) (Thyroid receptor-interacting protein 4) (TR-interacting protein 4) (TRIP-4) | TRIP4 | intracellular estrogen receptor signaling pathway [GO:0030520]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of myoblast differentiation [GO:0045661]; rescue of stalled ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116] | activating signal cointegrator 1 complex [GO:0099053]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuromuscular junction [GO:0031594]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] | histone acetyltransferase binding [GO:0035035]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor binding [GO:0016922]; protease binding [GO:0002020]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713]; ubiquitin-like protein ligase binding [GO:0044389]; zinc ion binding [GO:0008270] | 9731.145517638804 | 0.0793402328960735 | 0.871049356811075 | 1 |
| Q15654 | Q15654 | TRIP6_HUMAN | Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1) | TRIP6 | chordate embryonic development [GO:0043009]; focal adhesion assembly [GO:0048041]; positive regulation of cell migration [GO:0030335]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; signal transduction [GO:0007165] | cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stress fiber [GO:0001725] | interleukin-1 receptor binding [GO:0005149]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; nuclear thyroid hormone receptor binding [GO:0046966]; RNA binding [GO:0003723] | 18236.2889357364 | 0.0311104122863828 | 0.954729173142892 | 1 |
| Q9NXH9 | Q9NXH9 | TRM1_HUMAN | tRNA (guanine(26)-N(2))-dimethyltransferase (EC 2.1.1.216) (tRNA 2,2-dimethylguanosine-26 methyltransferase) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase) | TRMT1 | tRNA modification [GO:0006400]; tRNA N2-guanine methylation [GO:0002940] | nucleoplasm [GO:0005654]; nucleus [GO:0005634] | metal ion binding [GO:0046872]; RNA binding [GO:0003723]; tRNA (guanine(10)-N2)-methyltransferase activity [GO:0160102]; tRNA (guanine(26)-N2)-dimethyltransferase activity [GO:0160104]; tRNA binding [GO:0000049] | 3796.243521671295 | -0.0916062508024153 | 0.664831988712233 | 1 |
| Q7L0Y3 | Q7L0Y3 | TM10C_HUMAN | tRNA methyltransferase 10 homolog C (HBV pre-S2 trans-regulated protein 2) (Mitochondrial ribonuclease P protein 1) (Mitochondrial RNase P protein 1) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (Renal carcinoma antigen NY-REN-49) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-) (tRNA (adenine(9)-N(1))-methyltransferase) (EC 2.1.1.218) (tRNA (guanine(9)-N(1))-methyltransferase) (EC 2.1.1.221) | TRMT10C | mitochondrial RNA 5'-end processing [GO:0000964]; mitochondrial tRNA 3'-end processing [GO:1990180]; mitochondrial tRNA 5'-end processing [GO:0097745]; mitochondrial tRNA methylation [GO:0070901]; mitochondrial tRNA processing [GO:0090646]; mRNA methylation [GO:0080009]; positive regulation of mitochondrial translation [GO:0070131] | mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrial ribonuclease P complex [GO:0030678]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA methyltransferase complex [GO:0043527] | identical protein binding [GO:0042802]; RNA binding [GO:0003723]; tRNA (adenine(9)-N1)-methyltransferase activity [GO:0160106]; tRNA (guanosine(9)-N1)-methyltransferase activity [GO:0052905]; tRNA binding [GO:0000049] | 7438.75944034702 | 0.0551706409454804 | 0.958117801970972 | 1 |
| Q7Z4G4 | Q7Z4G4 | TRM11_HUMAN | tRNA (guanine(10)-N2)-methyltransferase homolog (EC 2.1.1.-) (tRNA guanosine-2'-O-methyltransferase TRM11 homolog) | TRMT11 | RNA methylation [GO:0001510]; tRNA processing [GO:0008033] | cytoplasm [GO:0005737] | methyltransferase activity [GO:0008168]; tRNA binding [GO:0000049] | 2580.9370727711103 | 0.128755213131368 | 0.991063737261339 | 1 |
| Q7Z2T5 | Q7Z2T5 | TRM1L_HUMAN | TRMT1-like protein (EC 2.1.1.-) | TRMT1L | behavior [GO:0007610]; tRNA N2-guanine methylation [GO:0002940] | nucleus [GO:0005634] | metal ion binding [GO:0046872]; RNA binding [GO:0003723]; tRNA (guanine(10)-N2)-methyltransferase activity [GO:0160102]; tRNA binding [GO:0000049] | 2662.994176095255 | 0.13758572553317 | 0.943718225446818 | 1 |
| Q32P41 | Q32P41 | TRM5_HUMAN | tRNA (guanine(37)-N1)-methyltransferase (EC 2.1.1.228) (M1G-methyltransferase) (tRNA [GM37] methyltransferase) (tRNA methyltransferase 5 homolog) | TRMT5 | mitochondrial tRNA methylation [GO:0070901]; tRNA N1-guanine methylation [GO:0002939] | cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634] | tRNA (guanine(37)-N1)-methyltransferase activity [GO:0052906]; tRNA methyltransferase activity [GO:0008175] | 3972.8474612941945 | -0.933810344034173 | 0.969661691634166 | 1 |
| Q8WWH5 | Q8WWH5 | TRUB1_HUMAN | Pseudouridylate synthase TRUB1 (EC 5.4.99.-) (TruB pseudouridine synthase homolog 1) (tRNA pseudouridine 55 synthase TRUB1) (Psi55 synthase TRUB1) (EC 5.4.99.25) | TRUB1 | mRNA processing [GO:0006397]; mRNA pseudouridine synthesis [GO:1990481]; positive regulation of pre-miRNA processing [GO:2000633]; tRNA modification [GO:0006400] | cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634] | pre-miRNA binding [GO:0070883]; pseudouridine synthase activity [GO:0009982]; tRNA pseudouridine synthase activity [GO:0106029] | 5431.60106268662 | -0.0397328058077585 | 0.999896463301046 | 1 |
| Q92574 | Q92574 | TSC1_HUMAN | Hamartin (Tuberous sclerosis 1 protein) | TSC1 | activation of GTPase activity [GO:0090630]; adaptive immune response [GO:0002250]; adult locomotory behavior [GO:0008344]; associative learning [GO:0008306]; cardiac muscle cell differentiation [GO:0055007]; cell population proliferation [GO:0008283]; cell projection organization [GO:0030030]; cell-matrix adhesion [GO:0007160]; cellular response to decreased oxygen levels [GO:0036294]; cellular response to starvation [GO:0009267]; cerebral cortex development [GO:0021987]; glucose import [GO:0046323]; hippocampus development [GO:0021766]; kidney development [GO:0001822]; memory T cell differentiation [GO:0043379]; myelination [GO:0042552]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell size [GO:0045792]; negative regulation of macroautophagy [GO:0016242]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of translation [GO:0017148]; neural tube closure [GO:0001843]; positive regulation of focal adhesion assembly [GO:0051894]; potassium ion transport [GO:0006813]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]; regulation of cell-matrix adhesion [GO:0001952]; regulation of phosphoprotein phosphatase activity [GO:0043666]; regulation of stress fiber assembly [GO:0051492]; regulation of translation [GO:0006417]; response to insulin [GO:0032868]; ribosomal subunit export from nucleus [GO:0000054]; synapse organization [GO:0050808] | cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein folding chaperone complex [GO:0101031]; protein-containing complex [GO:0032991]; TSC1-TSC2 complex [GO:0033596] | ATPase inhibitor activity [GO:0042030]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; protein-folding chaperone binding [GO:0051087] | 2500.20548822019 | -0.271910960002382 | 0.719189861947337 | 1 |
| P49815 | P49815 | TSC2_HUMAN | Tuberin (Tuberous sclerosis 2 protein) | TSC2 | anoikis [GO:0043276]; cellular response to starvation [GO:0009267]; endocytosis [GO:0006897]; heart development [GO:0007507]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of mitophagy [GO:1901525]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of Wnt signaling pathway [GO:0030178]; neural tube closure [GO:0001843]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive chemotaxis [GO:0050918]; positive regulation of macroautophagy [GO:0016239]; protein import into nucleus [GO:0006606]; protein localization [GO:0008104]; regulation of cell cycle [GO:0051726]; regulation of endocytosis [GO:0030100]; regulation of insulin receptor signaling pathway [GO:0046626]; regulation of small GTPase mediated signal transduction [GO:0051056]; vesicle-mediated transport [GO:0016192] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; TSC1-TSC2 complex [GO:0033596] | GTPase activator activity [GO:0005096]; Hsp90 protein binding [GO:0051879]; phosphatase binding [GO:0019902]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267] | 5632.1970351868 | -0.547028824815994 | 0.889837023532728 | 1 |
| Q8WUA8 | Q8WUA8 | TSK_HUMAN | Tsukushi (E2-induced gene 4 protein) (Leucine-rich repeat-containing protein 54) | TSKU | anterior commissure morphogenesis [GO:0021960]; bone growth [GO:0098868]; camera-type eye development [GO:0043010]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; ciliary body morphogenesis [GO:0061073]; corpus callosum morphogenesis [GO:0021540]; energy homeostasis [GO:0097009]; growth plate cartilage chondrocyte development [GO:0003431]; hippocampus development [GO:0021766]; inner ear receptor cell stereocilium organization [GO:0060122]; lateral ventricle development [GO:0021670]; negative regulation of myofibroblast differentiation [GO:1904761]; negative regulation of neuron projection development [GO:0010977]; negative regulation of transforming growth factor beta1 production [GO:0032911]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of hair cycle [GO:0042635]; regulation of gene expression [GO:0010468]; wound healing [GO:0042060] | extracellular matrix [GO:0031012]; extracellular space [GO:0005615] | transforming growth factor beta binding [GO:0050431] | 5165.2017101333 | -0.102732442214055 | 0.898997268536847 | 1 |
| O75954 | O75954 | TSN9_HUMAN | Tetraspanin-9 (Tspan-9) (Tetraspan NET-5) | TSPAN9 | focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; tetraspanin-enriched microdomain [GO:0097197] | 15157.04175637775 | 0.0836812774538706 | 0.895303672692417 | 1 | ||
| Q2NL82 | Q2NL82 | TSR1_HUMAN | Pre-rRNA-processing protein TSR1 homolog | TSR1 | endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000479]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462] | cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, small subunit precursor [GO:0030688] | GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; U3 snoRNA binding [GO:0034511] | 10640.212266463801 | 0.110390470504671 | 0.986594874295677 | 1 |
| Q16762 | Q16762 | THTR_HUMAN | Thiosulfate sulfurtransferase (EC 2.8.1.1) (Rhodanese) | TST | cyanate catabolic process [GO:0009440]; epithelial cell differentiation [GO:0030855]; rRNA import into mitochondrion [GO:0035928]; rRNA transport [GO:0051029]; sulfur amino acid catabolic process [GO:0000098] | extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] | 3-mercaptopyruvate sulfurtransferase activity [GO:0016784]; 5S rRNA binding [GO:0008097]; thiosulfate sulfurtransferase activity [GO:0004792] | 45510.814570919145 | -0.0987345692427223 | 0.743497592621608 | 1 |
| Q14166 | Q14166 | TTL12_HUMAN | Tubulin--tyrosine ligase-like protein 12 (Inactive tubulin--tyrosine ligase-like protein 12) | TTLL12 | innate immune response [GO:0045087]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; protein modification process [GO:0036211]; regulation of mitotic cell cycle [GO:0007346] | centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819] | ATP binding [GO:0005524]; H4K20me3 modified histone binding [GO:1990889]; tubulin binding [GO:0015631] | 13497.3418479422 | -0.0243218127379882 | 0.999689546114047 | 1 |
| Q9C0H2 | Q9C0H2 | TTYH3_HUMAN | Protein tweety homolog 3 (hTTY3) (Volume-regulated anion channel subunit TTYH3) | TTYH3 | chloride transport [GO:0006821]; monoatomic ion transmembrane transport [GO:0034220] | chloride channel complex [GO:0034707]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] | calcium ion binding [GO:0005509]; chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]; volume-sensitive chloride channel activity [GO:0072320] | 15898.85365423365 | 0.0573690754742958 | 0.931293356178902 | 1 |
| P0DPH7;P0DPH8 | P0DPH7 | TBA3C_HUMAN | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | TUBA3C | microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278] | cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634] | GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200] | 362899.9384143825 | -0.114567052822491 | 0.8592156196703 | 1 |
| Q13509 | Q13509 | TBB3_HUMAN | Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) | TUBB3 | axon guidance [GO:0007411]; dorsal root ganglion development [GO:1990791]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278] | axon [GO:0030424]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; growth cone [GO:0030426]; intercellular bridge [GO:0045171]; lamellipodium [GO:0030027]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; neuronal cell body [GO:0043025]; nucleus [GO:0005634] | GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; netrin receptor binding [GO:1990890]; peptide binding [GO:0042277]; structural constituent of cytoskeleton [GO:0005200] | 130069.60330891749 | 0.129880285727555 | 0.681391561048266 | 1 |
| Q9BSJ2 | Q9BSJ2 | GCP2_HUMAN | Gamma-tubulin complex component 2 (GCP-2) (hGCP2) (Gamma-ring complex protein 103 kDa) (h103p) (hGrip103) (Spindle pole body protein Spc97 homolog) (hSpc97) | TUBGCP2 | brain development [GO:0007420]; cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; neuron migration [GO:0001764]; protein-containing complex assembly [GO:0065003]; spindle assembly [GO:0051225] | centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; equatorial microtubule organizing center [GO:0000923]; gamma-tubulin complex [GO:0000930]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; spindle pole [GO:0000922] | gamma-tubulin binding [GO:0043015]; microtubule minus-end binding [GO:0051011] | 7351.263466272815 | -0.0489278620799408 | 0.999740171359319 | 1 |
| Q9UGJ1 | Q9UGJ1 | GCP4_HUMAN | Gamma-tubulin complex component 4 (GCP-4) (hGCP4) (Gamma-ring complex protein 76 kDa) (h76p) (hGrip76) | TUBGCP4 | cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; protein-containing complex assembly [GO:0065003]; spindle assembly [GO:0051225] | centrosome [GO:0005813]; cytosol [GO:0005829]; equatorial microtubule organizing center [GO:0000923]; gamma-tubulin complex [GO:0000930]; gamma-tubulin ring complex [GO:0000931]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; recycling endosome [GO:0055037]; spindle pole [GO:0000922] | gamma-tubulin binding [GO:0043015]; microtubule minus-end binding [GO:0051011]; structural constituent of cytoskeleton [GO:0005200] | 817.5380678712511 | -0.023682537155455 | 0.93293341461 | 1 |
| Q96RT7 | Q96RT7 | GCP6_HUMAN | Gamma-tubulin complex component 6 (GCP-6) | TUBGCP6 | cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; spindle assembly [GO:0051225] | centrosome [GO:0005813]; cytosol [GO:0005829]; equatorial microtubule organizing center [GO:0000923]; gamma-tubulin complex [GO:0000930]; gamma-tubulin ring complex [GO:0000931]; membrane [GO:0016020]; microtubule [GO:0005874]; spindle pole [GO:0000922] | gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017]; microtubule minus-end binding [GO:0051011] | 5807.801731576716 | 0.0985534192848923 | 0.886532369939047 | 1 |
| Q6IBS0 | Q6IBS0 | TWF2_HUMAN | Twinfilin-2 (A6-related protein) (hA6RP) (Protein tyrosine kinase 9-like) (Twinfilin-1-like protein) | TWF2 | actin filament depolymerization [GO:0030042]; barbed-end actin filament capping [GO:0051016]; cell projection organization [GO:0030030]; cellular response to growth factor stimulus [GO:0071363]; cellular response to retinoic acid [GO:0071300]; negative regulation of actin filament polymerization [GO:0030837]; positive regulation of axon extension [GO:0045773]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neuron projection development [GO:0010976]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of lamellipodium assembly [GO:0010591]; regulation of microvillus length [GO:0032532]; sequestering of actin monomers [GO:0042989] | actin filament [GO:0005884]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; myofibril [GO:0030016]; perinuclear region of cytoplasm [GO:0048471]; stereocilium [GO:0032420] | actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein kinase C binding [GO:0005080]; RNA binding [GO:0003723] | 61632.07763613525 | 0.0456397291374843 | 0.921510036464765 | 1 |
| Q99757 | Q99757 | THIOM_HUMAN | Thioredoxin, mitochondrial (MTRX) (Mt-Trx) (Thioredoxin-2) | TXN2 | cell redox homeostasis [GO:0045454]; cellular response to nutrient levels [GO:0031669]; response to axon injury [GO:0048678]; response to glucose [GO:0009749]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; response to organic cyclic compound [GO:0014070]; response to oxidative stress [GO:0006979]; response to xenobiotic stimulus [GO:0009410] | dendrite [GO:0030425]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730] | peptide-methionine (R)-S-oxide reductase activity [GO:0033743]; peptide-methionine (S)-S-oxide reductase activity [GO:0008113]; protein-containing complex binding [GO:0044877]; protein-disulfide reductase activity [GO:0015035] | 7163.48576362233 | 0.0931429102496542 | 0.788444421749515 | 1 |
| O95881 | O95881 | TXD12_HUMAN | Thioredoxin domain-containing protein 12 (EC 1.8.4.2) (Endoplasmic reticulum resident protein 18) (ER protein 18) (ERp18) (Endoplasmic reticulum resident protein 19) (ER protein 19) (ERp19) (Thioredoxin-like protein p19) (hTLP19) | TXNDC12 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788] | protein-disulfide reductase (glutathione) activity [GO:0019153]; protein-disulfide reductase activity [GO:0015035] | 94678.43511097171 | 0.00932368261173551 | 0.999974693985664 | 1 |
| P26368 | P26368 | U2AF2_HUMAN | Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (hU2AF(65)) (hU2AF65) (U2 snRNP auxiliary factor large subunit) | U2AF2 | mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of RNA splicing [GO:0033120]; spliceosomal complex assembly [GO:0000245] | commitment complex [GO:0000243]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type prespliceosome [GO:0071004]; U2AF complex [GO:0089701] | C2H2 zinc finger domain binding [GO:0070742]; enzyme binding [GO:0019899]; molecular function inhibitor activity [GO:0140678]; poly-pyrimidine tract binding [GO:0008187]; pre-mRNA 3'-splice site binding [GO:0030628]; RNA binding [GO:0003723] | 39600.94421647235 | 0.0353035231172004 | 0.995442976373247 | 1 |
| Q9UBT2 | Q9UBT2 | SAE2_HUMAN | SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) | UBA2 | positive regulation of protein sumoylation [GO:0033235]; protein sumoylation [GO:0016925] | cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; SUMO activating enzyme complex [GO:0031510] | ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein heterodimerization activity [GO:0046982]; small protein activating enzyme binding [GO:0044388]; SUMO activating enzyme activity [GO:0019948]; SUMO binding [GO:0032183]; transferase activity [GO:0016740]; ubiquitin-like protein conjugating enzyme binding [GO:0044390] | 23456.451826972698 | -0.0789574190308243 | 0.995108552675882 | 1 |
| Q8TBC4 | Q8TBC4 | UBA3_HUMAN | NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3) | UBA3 | endomitotic cell cycle [GO:0007113]; post-translational protein modification [GO:0043687]; protein modification process [GO:0036211]; protein neddylation [GO:0045116]; proteolysis [GO:0006508]; regulation of cell cycle [GO:0051726] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] | ATP binding [GO:0005524]; identical protein binding [GO:0042802]; NEDD8 activating enzyme activity [GO:0019781]; NEDD8 transferase activity [GO:0019788]; protein heterodimerization activity [GO:0046982] | 9903.111005018956 | 0.0373415616996141 | 0.999919953973726 | 1 |
| Q9GZZ9 | Q9GZZ9 | UBA5_HUMAN | Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1) | UBA5 | erythrocyte differentiation [GO:0030218]; localization [GO:0051179]; megakaryocyte differentiation [GO:0030219]; neuromuscular process [GO:0050905]; protein K69-linked ufmylation [GO:1990592]; protein ufmylation [GO:0071569]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; response to endoplasmic reticulum stress [GO:0034976]; reticulophagy [GO:0061709] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634] | ATP binding [GO:0005524]; protein homodimerization activity [GO:0042803]; UFM1 activating enzyme activity [GO:0071566]; zinc ion binding [GO:0008270] | 28371.0635691388 | 0.248352935110516 | 0.747318857888684 | 1 |
| A0AVT1 | A0AVT1 | UBA6_HUMAN | Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2) | UBA6 | amygdala development [GO:0021764]; dendritic spine development [GO:0060996]; DNA damage response [GO:0006974]; hippocampus development [GO:0021766]; learning [GO:0007612]; locomotory behavior [GO:0007626]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] | ATP binding [GO:0005524]; FAT10 activating enzyme activity [GO:0019780]; nucleotidyltransferase activity [GO:0016779]; thiosulfate sulfurtransferase activity [GO:0004792]; ubiquitin activating enzyme activity [GO:0004839] | 29637.74791979 | -0.0763752504855514 | 0.999775230708916 | 1 |
| Q9BSL1 | Q9BSL1 | UBAC1_HUMAN | Ubiquitin-associated domain-containing protein 1 (UBA domain-containing protein 1) (Glialblastoma cell differentiation-related protein 1) (Kip1 ubiquitination-promoting complex protein 2) | UBAC1 | protein maturation [GO:0051604]; protein ubiquitination [GO:0016567] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151] | polyubiquitin modification-dependent protein binding [GO:0031593]; proteasome binding [GO:0070628] | 6037.24139242191 | 0.0269291270638741 | 0.999061164391615 | 1 |
| Q8NBM4 | Q8NBM4 | UBAC2_HUMAN | Ubiquitin-associated domain-containing protein 2 (UBA domain-containing protein 2) (Phosphoglycerate dehydrogenase-like protein 1) | UBAC2 | negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein localization to endoplasmic reticulum [GO:0070972]; Wnt signaling pathway [GO:0016055] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] | serine-type endopeptidase activity [GO:0004252] | 10699.46559311895 | -0.0789923941621181 | 0.982290592561538 | 1 |
| Q9NZ09 | Q9NZ09 | UBAP1_HUMAN | Ubiquitin-associated protein 1 (UBAP-1) (Nasopharyngeal carcinoma-associated gene 20 protein) | UBAP1 | membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] | ubiquitin binding [GO:0043130] | 10310.998867832299 | 0.0951697746335798 | 0.951692514863895 | 1 |
| Q5T6F2 | Q5T6F2 | UBAP2_HUMAN | Ubiquitin-associated protein 2 (UBAP-2) (RNA polymerase II degradation factor UBAP2) | UBAP2 | regulation of gene expression [GO:0010468] | chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; P-body [GO:0000932] | cadherin binding [GO:0045296]; RNA binding [GO:0003723] | 5814.068162757259 | -0.0137666197859721 | 0.999975021049992 | 1 |
| Q14157 | Q14157 | UBP2L_HUMAN | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | UBAP2L | binding of sperm to zona pellucida [GO:0007339]; hematopoietic stem cell homeostasis [GO:0061484]; positive regulation of stress granule assembly [GO:0062029]; stress granule assembly [GO:0034063] | chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleus [GO:0005634]; PcG protein complex [GO:0031519] | RNA binding [GO:0003723] | 61379.031663244445 | 0.0750819342020665 | 0.861580378894279 | 1 |
| Q969T4 | Q969T4 | UB2E3_HUMAN | Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (UbcH9) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3) | UBE2E3 | protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534] | cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842] | 15688.356644836 | 0.0870173197087284 | 0.815884892044704 | 1 |
| Q05086 | Q05086 | UBE3A_HUMAN | Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54) | UBE3A | androgen receptor signaling pathway [GO:0030521]; brain development [GO:0007420]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; locomotory exploration behavior [GO:0035641]; motor learning [GO:0061743]; negative regulation of dendritic spine morphogenesis [GO:0061002]; negative regulation of TORC1 signaling [GO:1904262]; ovarian follicle development [GO:0001541]; positive regulation of Golgi lumen acidification [GO:1905528]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone receptor signaling pathway [GO:0050847]; prostate gland growth [GO:0060736]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; proteolysis [GO:0006508]; regulation of circadian rhythm [GO:0042752]; regulation of synaptic plasticity [GO:0048167]; regulation of ubiquitin-dependent protein catabolic process [GO:2000058]; response to cocaine [GO:0042220]; response to hydrogen peroxide [GO:0042542]; response to progesterone [GO:0032570]; rhythmic process [GO:0048511]; sperm entry [GO:0035037]; ubiquitin-dependent protein catabolic process [GO:0006511] | cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; proteasome complex [GO:0000502] | metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] | 8736.8480212129 | -0.0795783154882873 | 0.99946490378767 | 1 |
| Q7Z3V4 | Q7Z3V4 | UBE3B_HUMAN | Ubiquitin-protein ligase E3B (EC 2.3.2.26) (HECT-type ubiquitin transferase E3B) | UBE3B | protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] | ubiquitin protein ligase activity [GO:0061630] | 1741.828845391015 | 0.553691438865222 | 0.88936308980863 | 1 | |
| Q15386 | Q15386 | UBE3C_HUMAN | Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL) | UBE3C | protein K29-linked ubiquitination [GO:0035519]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] | proteasome complex [GO:0000502] | ubiquitin protein ligase activity [GO:0061630] | 11321.8143804923 | -0.0163589410037105 | 0.999999999970328 | 1 |
| Q14139 | Q14139 | UBE4A_HUMAN | Ubiquitin conjugation factor E4 A (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4 A) | UBE4A | ERAD pathway [GO:0036503]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] | cytoplasm [GO:0005737]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] | ubiquitin-ubiquitin ligase activity [GO:0034450] | 6279.577397370105 | -0.23775121832654 | 0.755369060033381 | 1 |
| O95155 | O95155 | UBE4B_HUMAN | Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2) | UBE4B | ERAD pathway [GO:0036503]; granzyme-mediated apoptotic signaling pathway [GO:0008626]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; response to UV [GO:0009411]; ubiquitin-dependent protein catabolic process [GO:0006511] | cytoplasm [GO:0005737]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] | enzyme binding [GO:0019899]; ubiquitin-ubiquitin ligase activity [GO:0034450] | 12472.95844961135 | -0.288526954935534 | 0.736341265435955 | 1 |
| O14562 | O14562 | UBFD1_HUMAN | Ubiquitin domain-containing protein UBFD1 (Ubiquitin-binding protein homolog) | UBFD1 | cadherin binding [GO:0045296]; RNA binding [GO:0003723] | 60383.63268131571 | 0.105387219498827 | 0.706274428135425 | 1 | ||
| Q96S82 | Q96S82 | UBL7_HUMAN | Ubiquitin-like protein 7 (Bone marrow stromal cell ubiquitin-like protein) (BMSC-UbP) (Ubiquitin-like protein SB132) | UBL7 | defense response to virus [GO:0051607]; innate immune response [GO:0045087]; ubiquitin-dependent protein catabolic process [GO:0006511] | cytoplasm [GO:0005737]; cytosol [GO:0005829] | molecular adaptor activity [GO:0060090]; polyubiquitin modification-dependent protein binding [GO:0031593] | 8793.18458490999 | 0.145408634324862 | 0.737144332199287 | 1 |
| Q9NZI7 | Q9NZI7 | UBIP1_HUMAN | Upstream-binding protein 1 (Transcription factor LBP-1) | UBP1 | angiogenesis [GO:0001525]; negative regulation of viral transcription [GO:0032897]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] | chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837] | 4963.125201088895 | 0.0516183465927572 | 0.912592001625394 | 1 |
| Q9NRR5 | Q9NRR5 | UBQL4_HUMAN | Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75) | UBQLN4 | autophagy [GO:0006914]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; negative regulation of autophagosome maturation [GO:1901097]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; ubiquitin-dependent protein catabolic process [GO:0006511] | autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; site of DNA damage [GO:0090734] | identical protein binding [GO:0042802]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; polyubiquitin modification-dependent protein binding [GO:0031593] | 16072.508190800148 | 0.117331714712365 | 0.755659752355899 | 1 |
| Q8IWV7 | Q8IWV7 | UBR1_HUMAN | E3 ubiquitin-protein ligase UBR1 (EC 2.3.2.27) (N-recognin-1) (RING-type E3 ubiquitin transferase UBR1) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3-alpha-I) | UBR1 | cellular response to leucine [GO:0071233]; negative regulation of TOR signaling [GO:0032007]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; proteasome complex [GO:0000502]; ubiquitin ligase complex [GO:0000151] | leucine binding [GO:0070728]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] | 4597.275646574865 | -0.272203279787208 | 0.823037644828633 | 1 |
| Q8IWV8 | Q8IWV8 | UBR2_HUMAN | E3 ubiquitin-protein ligase UBR2 (EC 2.3.2.27) (N-recognin-2) (RING-type E3 ubiquitin transferase UBR2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II) | UBR2 | cellular response to leucine [GO:0071233]; heterochromatin formation [GO:0031507]; male meiosis I [GO:0007141]; male meiotic nuclear division [GO:0007140]; negative regulation of TOR signaling [GO:0032007]; protein ubiquitination [GO:0016567]; reciprocal meiotic recombination [GO:0007131]; retrotransposon silencing [GO:0010526]; spermatogenesis [GO:0007283]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596] | chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] | histone ubiquitin ligase activity [GO:0140852]; leucine binding [GO:0070728]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] | 3117.649810736585 | 0.103774338256347 | 0.934995975299189 | 1 |
| Q5T4S7 | Q5T4S7 | UBR4_HUMAN | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (N-recognin-4) (RING-type E3 ubiquitin transferase UBR4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) (p600) (Zinc finger UBR1-type protein 1) | UBR4 | negative regulation of fatty acid biosynthetic process [GO:0045717]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] | centrosome [GO:0005813]; cytosol [GO:0005829]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] | calmodulin binding [GO:0005516]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] | 9736.132186512681 | -0.140927863900785 | 0.999311537616181 | 1 |
| Q8WUN7 | Q8WUN7 | UBTD2_HUMAN | Ubiquitin domain-containing protein 2 (Dendritic cell-derived ubiquitin-like protein) (DC-UbP) (Ubiquitin-like protein SB72) | UBTD2 | cytoplasm [GO:0005737] | 11320.683736837549 | 0.118962794603897 | 0.854965502925167 | 1 | ||
| P17480 | P17480 | UBF1_HUMAN | Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1) | UBTF | positive regulation of transcription by RNA polymerase I [GO:0045943]; transcription by RNA polymerase I [GO:0006360]; transcription initiation at RNA polymerase I promoter [GO:0006361] | fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | chromatin binding [GO:0003682]; RNA binding [GO:0003723]; RNA polymerase I cis-regulatory region sequence-specific DNA binding [GO:0001165]; RNA polymerase I core promoter sequence-specific DNA binding [GO:0001164]; RNA polymerase I general transcription initiation factor activity [GO:0001181]; scaffold protein binding [GO:0097110] | 15503.35369693135 | 0.057473948622273 | 0.992728463854333 | 1 |
| Q9BZV1 | Q9BZV1 | UBXN6_HUMAN | UBX domain-containing protein 6 (UBX domain-containing protein 1) | UBXN6 | endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; ERAD pathway [GO:0036503]; macroautophagy [GO:0016236] | centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] | 16325.2270117178 | -0.0730450888604982 | 0.73864204326088 | 1 | |
| O94888 | O94888 | UBXN7_HUMAN | UBX domain-containing protein 7 | UBXN7 | proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] | cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098] | RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625] | 23119.3211652445 | -0.109715605767549 | 0.87583362232392 | 1 |
| P09936 | P09936 | UCHL1_HUMAN | Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) (EC 3.4.19.12) (Neuron cytoplasmic protein 9.5) (PGP 9.5) (PGP9.5) (Ubiquitin thioesterase L1) | UCHL1 | adult walking behavior [GO:0007628]; axon target recognition [GO:0007412]; axonal transport of mitochondrion [GO:0019896]; cellular response to xenobiotic stimulus [GO:0071466]; eating behavior [GO:0042755]; male germ cell proliferation [GO:0002176]; muscle cell development [GO:0055001]; negative regulation of MAP kinase activity [GO:0043407]; neuromuscular process [GO:0050905]; positive regulation of glycolytic process [GO:0045821]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; regulation of macroautophagy [GO:0016241]; response to ischemia [GO:0002931] | axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654] | alpha-2A adrenergic receptor binding [GO:0031694]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; omega peptidase activity [GO:0008242]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625] | 265412.7378642325 | 0.0598424534497248 | 0.680356529070476 | 1 |
| Q9BZX2 | Q9BZX2 | UCK2_HUMAN | Uridine-cytidine kinase 2 (UCK 2) (EC 2.7.1.48) (Cytidine monophosphokinase 2) (Testis-specific protein TSA903) (Uridine monophosphokinase 2) | UCK2 | CTP salvage [GO:0044211]; phosphorylation [GO:0016310]; UMP salvage [GO:0044206] | cytoplasm [GO:0005737]; cytosol [GO:0005829] | ATP binding [GO:0005524]; cytidine kinase activity [GO:0043771]; identical protein binding [GO:0042802]; ribosylnicotinamide kinase activity [GO:0050262]; uridine kinase activity [GO:0004849] | 15593.35667212405 | -0.0466043091473865 | 0.957694700004297 | 1 |
| P61960 | P61960 | UFM1_HUMAN | Ubiquitin-fold modifier 1 | UFM1 | brain development [GO:0007420]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein import into nucleus [GO:0042308]; protein K69-linked ufmylation [GO:1990592]; protein ufmylation [GO:0071569]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; response to endoplasmic reticulum stress [GO:0034976]; reticulophagy [GO:0061709] | cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] | 50061.65817894755 | 0.0764224773228337 | 0.79677394394224 | 1 | |
| Q9NUQ7 | Q9NUQ7 | UFSP2_HUMAN | Ufm1-specific protease 2 (UfSP2) (EC 3.4.22.-) | UFSP2 | proteolysis [GO:0006508]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146] | cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] | deUFMylase activity [GO:0071567] | 15601.32143243555 | 0.0566791410391058 | 0.98268015887474 | 1 |
| O60701 | O60701 | UGDH_HUMAN | UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) | UGDH | chondroitin sulfate biosynthetic process [GO:0030206]; gastrulation with mouth forming second [GO:0001702]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; neuron development [GO:0048666]; protein hexamerization [GO:0034214]; UDP-glucuronate biosynthetic process [GO:0006065] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | identical protein binding [GO:0042802]; NAD binding [GO:0051287]; UDP-glucose 6-dehydrogenase activity [GO:0003979] | 104198.5578482345 | -0.101019336120263 | 0.73425135951071 | 1 |
| Q92900 | Q92900 | RENT1_HUMAN | Regulator of nonsense transcripts 1 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1) | UPF1 | 3'-UTR-mediated mRNA destabilization [GO:0061158]; cell cycle phase transition [GO:0044770]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; histone mRNA catabolic process [GO:0071044]; mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of mRNA cis splicing, via spliceosome [GO:1905746]; regulation of telomere maintenance [GO:0032204]; regulation of translational termination [GO:0006449]; telomere maintenance via semi-conservative replication [GO:0032201] | chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]; supraspliceosomal complex [GO:0044530] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; double-stranded DNA helicase activity [GO:0036121]; helicase activity [GO:0004386]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; telomeric DNA binding [GO:0042162]; zinc ion binding [GO:0008270] | 19310.99282881625 | -0.123483591301123 | 0.896799225854967 | 1 |
| Q9NVA1 | Q9NVA1 | UQCC1_HUMAN | Ubiquinol-cytochrome c reductase complex assembly factor 1 (Basic FGF-repressed Zic-binding protein) (bFGF-repressed Zic-binding protein) (bFZb) (Ubiquinol-cytochrome c reductase complex chaperone CBP3 homolog) | UQCC1 | mitochondrial respiratory chain complex III assembly [GO:0034551] | cytoplasmic vesicle [GO:0031410]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] | 4168.14991285542 | -0.118159346624512 | 0.866684866574864 | 1 | |
| P31930 | P31930 | QCR1_HUMAN | Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1) | UQCRC1 | aerobic respiration [GO:0009060]; cellular respiration [GO:0045333]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; oxidative phosphorylation [GO:0006119]; response to activity [GO:0014823]; response to alkaloid [GO:0043279] | mitochondrial inner membrane [GO:0005743]; mitochondrial respirasome [GO:0005746]; mitochondrial respiratory chain complex III [GO:0005750]; mitochondrion [GO:0005739] | metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; ubiquinol-cytochrome-c reductase activity [GO:0008121]; ubiquitin protein ligase binding [GO:0031625] | 16652.563956216298 | 0.0519410682379249 | 0.882313241874849 | 1 |
| O14949 | O14949 | QCR8_HUMAN | Cytochrome b-c1 complex subunit 8 (Complex III subunit 8) (Complex III subunit VIII) (Ubiquinol-cytochrome c reductase complex 9.5 kDa protein) (Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C) | UQCRQ | cellular respiration [GO:0045333]; cerebellar Purkinje cell layer development [GO:0021680]; hippocampus development [GO:0021766]; hypothalamus development [GO:0021854]; midbrain development [GO:0030901]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; pons development [GO:0021548]; pyramidal neuron development [GO:0021860]; subthalamus development [GO:0021539]; thalamus development [GO:0021794] | mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex III [GO:0005750]; mitochondrion [GO:0005739] | 15226.758832254749 | 0.0256920935027287 | 0.950361216842191 | 1 | |
| O94763 | O94763 | RMP_HUMAN | Unconventional prefoldin RPB5 interactor 1 (Protein NNX3) (Protein phosphatase 1 regulatory subunit 19) (RNA polymerase II subunit 5-mediating protein) (RPB5-mediating protein) | URI1 | cellular response to growth factor stimulus [GO:0071363]; cellular response to steroid hormone stimulus [GO:0071383]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of phosphatase activity [GO:0010923]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein stabilization [GO:0050821]; regulation of cell growth [GO:0001558]; regulation of transcription by RNA polymerase II [GO:0006357]; response to virus [GO:0009615] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; RPAP3/R2TP/prefoldin-like complex [GO:1990062] | chromatin binding [GO:0003682]; phosphatase inhibitor activity [GO:0019212]; phosphoprotein binding [GO:0051219]; protein phosphatase inhibitor activity [GO:0004864]; RNA polymerase II complex binding [GO:0000993]; transcription corepressor activity [GO:0003714] | 12027.0590606602 | 0.0132027212233834 | 0.99841654591805 | 1 |
| Q9NZ43 | Q9NZ43 | USE1_HUMAN | Vesicle transport protein USE1 (Putative MAPK-activating protein PM26) (USE1-like protein) (p31) | USE1 | lysosomal transport [GO:0007041]; protein catabolic process [GO:0030163]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; secretion by cell [GO:0032940] | COPI-coated vesicle [GO:0030137]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; SNARE complex [GO:0031201] | SNAP receptor activity [GO:0005484] | 31086.57503924185 | 0.124179106193774 | 0.766956763728731 | 1 |
| O60763 | O60763 | USO1_HUMAN | General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) | USO1 | endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi vesicle docking [GO:0048211]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; regulation of cellular response to insulin stimulus [GO:1900076]; secretory granule localization [GO:0032252]; small GTPase-mediated signal transduction [GO:0007264]; transcytosis [GO:0045056]; vesicle fusion with Golgi apparatus [GO:0048280] | cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; ER to Golgi transport vesicle membrane [GO:0012507]; fibrillar center [GO:0001650]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; perinuclear region of cytoplasm [GO:0048471]; transport vesicle [GO:0030133] | cadherin binding [GO:0045296]; RNA binding [GO:0003723] | 57243.318193814106 | -0.100167423393109 | 0.776718934204509 | 1 |
| P51784 | P51784 | UBP11_HUMAN | Ubiquitin carboxyl-terminal hydrolase 11 (EC 3.4.19.12) (Deubiquitinating enzyme 11) (Ubiquitin thioesterase 11) (Ubiquitin-specific-processing protease 11) | USP11 | protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] | chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; transcription corepressor binding [GO:0001222] | 8360.522444709706 | 0.180872398802555 | 0.930272002034679 | 1 |
| P54578 | P54578 | UBP14_HUMAN | Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) | USP14 | chemical synaptic transmission [GO:0007268]; innate immune response [GO:0045087]; negative regulation of ERAD pathway [GO:1904293]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; regulation of chemotaxis [GO:0050920]; regulation of proteasomal protein catabolic process [GO:0061136] | cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; proteasome complex [GO:0000502]; synapse [GO:0045202] | cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005]; endopeptidase inhibitor activity [GO:0004866]; K63-linked deubiquitinase activity [GO:0061578]; proteasome binding [GO:0070628] | 34692.4650208705 | 0.0972974970846808 | 0.844341027136775 | 1 |
| Q9Y5T5 | Q9Y5T5 | UBP16_HUMAN | Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-processing protease UBP-M) (Ubiquitin-specific-processing protease 16) | USP16 | cell division [GO:0051301]; DNA damage response [GO:0006974]; mitotic nuclear division [GO:0140014]; monoubiquitinated protein deubiquitination [GO:0035520]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ribosome biogenesis [GO:0090070]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translational elongation [GO:0045901]; protein homotetramerization [GO:0051289]; proteolysis [GO:0006508]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357] | cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; histone binding [GO:0042393]; histone H2A deubiquitinase activity [GO:0140950]; ribosomal small subunit binding [GO:0043024]; transcription coactivator activity [GO:0003713]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270] | 9269.741891995276 | -0.00221948569975111 | 0.999929955251778 | 1 |
| O94966 | O94966 | UBP19_HUMAN | Ubiquitin carboxyl-terminal hydrolase 19 (EC 3.4.19.12) (Deubiquitinating enzyme 19) (Ubiquitin thioesterase 19) (Ubiquitin-specific-processing protease 19) (Zinc finger MYND domain-containing protein 9) | USP19 | ERAD pathway [GO:0036503]; negative regulation of skeletal muscle tissue development [GO:0048642]; positive regulation of cell cycle process [GO:0090068]; protein deubiquitination [GO:0016579]; protein stabilization [GO:0050821]; regulation of cellular response to hypoxia [GO:1900037]; regulation of ERAD pathway [GO:1904292]; regulation of protein stability [GO:0031647]; response to endoplasmic reticulum stress [GO:0034976] | cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789] | cysteine-type deubiquitinase activity [GO:0004843]; Hsp90 protein binding [GO:0051879]; metal ion binding [GO:0046872] | 3342.931151445 | -0.0365493074075594 | 0.970881055902469 | 1 |
| Q9UPU5 | Q9UPU5 | UBP24_HUMAN | Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) | USP24 | proteolysis [GO:0006508] | cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | cysteine-type deubiquitinase activity [GO:0004843] | 3398.0144173745703 | -0.201566391154953 | 0.887030733155612 | 1 |
| Q9UHP3 | Q9UHP3 | UBP25_HUMAN | Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) | USP25 | negative regulation of ERAD pathway [GO:1904293]; negative regulation of interleukin-17-mediated signaling pathway [GO:1903882]; negative regulation of response to oxidative stress [GO:1902883]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; protein modification process [GO:0036211]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] | ATPase binding [GO:0051117]; cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; peptidase activity [GO:0008233]; proteasome binding [GO:0070628]; SUMO binding [GO:0032183]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein peptidase activity [GO:0019783] | 5905.0725778602355 | -0.0982376707130313 | 0.993959091519973 | 1 |
| Q53GS9 | Q53GS9 | UBP39_HUMAN | Ubiquitin carboxyl-terminal hydrolase 39 (EC 3.4.19.12) (SAD1 homolog) (U4/U6.U5 tri-snRNP-associated 65 kDa protein) | USP39 | cell cycle [GO:0007049]; cell division [GO:0051301]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245] | nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U4/U6 x U5 tri-snRNP complex [GO:0046540] | hydrolase activity [GO:0016787]; zinc ion binding [GO:0008270] | 8016.49109072534 | -0.16487747593148 | 0.694505320408628 | 1 |
| P62068 | P62068 | UBP46_HUMAN | Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.4.19.12) (Deubiquitinating enzyme 46) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46) | USP46 | adult feeding behavior [GO:0008343]; behavioral fear response [GO:0001662]; behavioral response to ethanol [GO:0048149]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of synaptic transmission, GABAergic [GO:0032228]; righting reflex [GO:0060013] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] | cysteine-type deubiquitinase activity [GO:0004843]; metal ion binding [GO:0046872] | 6745.057027596689 | 0.081017021165751 | 0.70918705939703 | 1 |
| Q96K76 | Q96K76 | UBP47_HUMAN | Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) | USP47 | base-excision repair [GO:0006284]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell growth [GO:0030307]; proteolysis [GO:0006508]; response to xenobiotic stimulus [GO:0009410] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005] | cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; WD40-repeat domain binding [GO:0071987] | 8778.81411758163 | -0.103199119582489 | 0.868125521015062 | 1 |
| P45974 | P45974 | UBP5_HUMAN | Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) | USP5 | negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein K48-linked deubiquitination [GO:0071108]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508] | cytosol [GO:0005829]; lysosome [GO:0005764]; nucleus [GO:0005634] | cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270] | 40137.115301244005 | -0.0820626816800878 | 0.980471766662927 | 1 |
| Q70EK8 | Q70EK8 | UBP53_HUMAN | Inactive ubiquitin carboxyl-terminal hydrolase 53 (Inactive ubiquitin-specific peptidase 53) | USP53 | action potential [GO:0001508]; epithelial cell apoptotic process [GO:1904019]; outer hair cell apoptotic process [GO:1905584]; response to auditory stimulus [GO:0010996]; sensory perception of sound [GO:0007605] | bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911] | 1720.68985105917 | -0.510101477983791 | 0.808117373419345 | 1 | |
| Q93009 | Q93009 | UBP7_HUMAN | Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) | USP7 | DNA dealkylation involved in DNA repair [GO:0006307]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of gene expression via chromosomal CpG dinucleotide methylation [GO:0044027]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of TORC1 signaling [GO:1904262]; protein deubiquitination [GO:0016579]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of protein stability [GO:0031647]; regulation of retrograde transport, endosome to Golgi [GO:1905279]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of telomere capping [GO:1904353]; rhythmic process [GO:0048511]; symbiont-mediated disruption of host cell PML body [GO:0075342]; transcription-coupled nucleotide-excision repair [GO:0006283] | chromosome [GO:0005694]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991] | cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005]; K48-linked deubiquitinase activity [GO:1990380]; p53 binding [GO:0002039] | 11216.7535100979 | -0.150108263287753 | 0.940475811619977 | 1 |
| P40818 | P40818 | UBP8_HUMAN | Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) | USP8 | cellular response to dexamethasone stimulus [GO:0071549]; cellular response to nerve growth factor stimulus [GO:1990090]; endosome organization [GO:0007032]; mitotic cytokinesis [GO:0000281]; negative regulation of lysosomal protein catabolic process [GO:1905166]; positive regulation of amyloid fibril formation [GO:1905908]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; proteolysis [GO:0006508]; Ras protein signal transduction [GO:0007265]; regulation of protein catabolic process at postsynapse, modulating synaptic transmission [GO:0099576]; regulation of protein localization [GO:0032880]; regulation of protein stability [GO:0031647] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; extrinsic component of plasma membrane [GO:0019897]; glutamatergic synapse [GO:0098978]; midbody [GO:0030496]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] | cadherin binding [GO:0045296]; cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]; SH3 domain binding [GO:0017124] | 8020.817907891945 | -0.0379168676387723 | 0.995677985541892 | 1 |
| Q9Y2C2 | Q9Y2C2 | UST_HUMAN | Uronyl 2-sulfotransferase (EC 2.8.2.-) | UST | dermatan sulfate biosynthetic process [GO:0030208]; establishment of cell polarity [GO:0030010]; protein sulfation [GO:0006477]; regulation of axonogenesis [GO:0050770] | Golgi membrane [GO:0000139]; membrane [GO:0016020] | sulfotransferase activity [GO:0008146] | 5679.39032010864 | 0.194238690131128 | 0.727871464336324 | 1 |
| Q9BVJ6 | Q9BVJ6 | UT14A_HUMAN | U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) | UTP14A | rRNA processing [GO:0006364] | cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] | RNA binding [GO:0003723] | 6956.426387554349 | -0.0553473528867242 | 0.999987145882327 | 1 |
| Q8TED0 | Q8TED0 | UTP15_HUMAN | U3 small nucleolar RNA-associated protein 15 homolog | UTP15 | positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364] | cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] | RNA binding [GO:0003723] | 6450.815833523555 | 2.38633994954388E-4 | 0.999999999999907 | 1 |
| Q9Y5J1 | Q9Y5J1 | UTP18_HUMAN | U3 small nucleolar RNA-associated protein 18 homolog (WD repeat-containing protein 50) | UTP18 | ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364] | nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040] | RNA binding [GO:0003723] | 8200.50366958212 | -0.106467674132939 | 0.821798335276701 | 1 |
| Q969X6 | Q969X6 | UTP4_HUMAN | U3 small nucleolar RNA-associated protein 4 homolog (Cirhin) (UTP4 small subunit processome component) | UTP4 | maturation of SSU-rRNA [GO:0030490]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; regulation of DNA-templated transcription [GO:0006355]; ribosomal small subunit biogenesis [GO:0042274] | 90S preribosome [GO:0030686]; chromosome [GO:0005694]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; t-UTP complex [GO:0034455] | RNA binding [GO:0003723] | 3323.870980177685 | -0.320553632726384 | 0.822010339164375 | 1 |
| Q9NYH9 | Q9NYH9 | UTP6_HUMAN | U3 small nucleolar RNA-associated protein 6 homolog (Hepatocellular carcinoma-associated antigen 66) (Multiple hat domains protein) | UTP6 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274] | chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040] | snoRNA binding [GO:0030515] | 6272.951453815405 | -0.041829635350135 | 0.979029016805517 | 1 |
| Q6EMK4 | Q6EMK4 | VASN_HUMAN | Vasorin (Protein slit-like 2) | VASN | cellular response to hypoxia [GO:0071456]; cellular response to redox state [GO:0071461]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512] | cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] | cadherin binding [GO:0045296]; transforming growth factor beta binding [GO:0050431] | 40877.69076096375 | -0.0908239813924699 | 0.781650159465043 | 1 |
| Q96JH7 | Q96JH7 | VCIP1_HUMAN | Deubiquitinating protein VCPIP1 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein) | VCPIP1 | DNA damage response [GO:0006974]; endoplasmic reticulum membrane fusion [GO:0016320]; Golgi reassembly [GO:0090168]; protein deubiquitination [GO:0016579]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein ubiquitination [GO:0016567]; protein-DNA covalent cross-linking repair [GO:0106300]; proteolysis [GO:0006508]; regulation of protein localization to chromatin [GO:1905634] | cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; Golgi stack [GO:0005795]; nucleus [GO:0005634] | cysteine-type deubiquitinase activity [GO:0004843] | 4854.43644344725 | -0.158946478445708 | 0.967104210080993 | 1 |
| P21796 | P21796 | VDAC1_HUMAN | Voltage-dependent anion-selective channel protein 1 (VDAC-1) (hVDAC1) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) | VDAC1 | apoptotic process [GO:0006915]; behavioral fear response [GO:0001662]; epithelial cell differentiation [GO:0030855]; learning [GO:0007612]; monoatomic anion transport [GO:0006820]; negative regulation of apoptotic process [GO:0043066]; negative regulation of calcium import into the mitochondrion [GO:0110099]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; neuron-neuron synaptic transmission [GO:0007270]; positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [GO:1905091]; pyruvate metabolic process [GO:0006090]; regulation of autophagy of mitochondrion [GO:1903146] | extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrial membrane [GO:0031966]; mitochondrial nucleoid [GO:0042645]; mitochondrial outer membrane [GO:0005741]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; pore complex [GO:0046930]; synapse [GO:0045202] | ceramide binding [GO:0097001]; cholesterol binding [GO:0015485]; identical protein binding [GO:0042802]; oxysterol binding [GO:0008142]; phosphatidylcholine binding [GO:0031210]; porin activity [GO:0015288]; protein kinase binding [GO:0019901]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic anion channel activity [GO:0008308] | 348449.08233225555 | 0.0780871258550671 | 0.927155246746599 | 1 |
| P45880 | P45880 | VDAC2_HUMAN | Voltage-dependent anion-selective channel protein 2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2) | VDAC2 | binding of sperm to zona pellucida [GO:0007339]; mitochondrial outer membrane permeabilization [GO:0097345]; monoatomic anion transport [GO:0006820]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of protein polymerization [GO:0032272] | acrosomal vesicle [GO:0001669]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrial membrane [GO:0031966]; mitochondrial nucleoid [GO:0042645]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; pore complex [GO:0046930]; sperm midpiece [GO:0097225] | ceramide binding [GO:0097001]; cholesterol binding [GO:0015485]; nucleotide binding [GO:0000166]; oxysterol binding [GO:0008142]; phosphatidylcholine binding [GO:0031210]; porin activity [GO:0015288]; voltage-gated monoatomic anion channel activity [GO:0008308] | 163627.1735781525 | 0.0383043466317489 | 0.993959612554962 | 1 |
| P08670 | P08670 | VIME_HUMAN | Vimentin | VIM | astrocyte development [GO:0014002]; Bergmann glial cell differentiation [GO:0060020]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to muramyl dipeptide [GO:0071225]; cellular response to type II interferon [GO:0071346]; intermediate filament organization [GO:0045109]; lens fiber cell development [GO:0070307]; negative regulation of neuron projection development [GO:0010977]; neuron projection development [GO:0031175]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of gene expression [GO:0010628]; regulation of mRNA stability [GO:0043488] | axon [GO:0030424]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; intermediate filament [GO:0005882]; intermediate filament cytoskeleton [GO:0045111]; microtubule organizing center [GO:0005815]; nuclear matrix [GO:0016363]; peroxisome [GO:0005777]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886] | double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; keratin filament binding [GO:1990254]; molecular adaptor activity [GO:0060090]; protein domain specific binding [GO:0019904]; scaffold protein binding [GO:0097110]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of eye lens [GO:0005212] | 724947.9581806241 | -0.0151630837855679 | 1 | 1 |
| Q96RL7 | Q96RL7 | VP13A_HUMAN | Intermembrane lipid transfer protein VPS13A (Chorea-acanthocytosis protein) (Chorein) (Vacuolar protein sorting-associated protein 13A) | VPS13A | autophagy [GO:0006914]; flagellated sperm motility [GO:0030317]; Golgi to endosome transport [GO:0006895]; lipid transport [GO:0006869]; locomotory behavior [GO:0007626]; lysosomal protein catabolic process [GO:1905146]; nervous system development [GO:0007399]; protein localization [GO:0008104]; protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623]; social behavior [GO:0035176]; sperm mitochondrion organization [GO:0030382] | cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extrinsic component of membrane [GO:0019898]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; neuronal dense core vesicle lumen [GO:0099013]; sperm midpiece [GO:0097225] | 2356.534071343565 | 0.137002445890432 | 0.907488743180714 | 1 | |
| Q96AX1 | Q96AX1 | VP33A_HUMAN | Vacuolar protein sorting-associated protein 33A (hVPS33A) | VPS33A | autophagosome maturation [GO:0097352]; endosomal vesicle fusion [GO:0034058]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; lysosome localization [GO:0032418]; melanosome localization [GO:0032400]; platelet formation [GO:0030220]; regulation of developmental pigmentation [GO:0048070]; regulation of lysosomal lumen pH [GO:0035751]; regulation of SNARE complex assembly [GO:0035542]; vesicle-mediated transport [GO:0016192] | autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471] | 5897.468975571395 | -0.123756238536829 | 0.904470402380276 | 1 | |
| Q9H267 | Q9H267 | VP33B_HUMAN | Vacuolar protein sorting-associated protein 33B (hVPS33B) | VPS33B | collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; endosome organization [GO:0007032]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; lysosome localization [GO:0032418]; megakaryocyte development [GO:0035855]; melanosome localization [GO:0032400]; membrane fusion [GO:0061025]; peptidyl-lysine hydroxylation [GO:0017185]; phagosome-lysosome fusion [GO:0090385]; platelet alpha granule organization [GO:0070889]; protein transport [GO:0015031]; regulation of platelet aggregation [GO:0090330]; skin morphogenesis [GO:0043589]; vesicle-mediated transport [GO:0016192] | clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; platelet alpha granule [GO:0031091]; recycling endosome [GO:0055037]; vesicle tethering complex [GO:0099023] | protein-containing complex binding [GO:0044877] | 11248.4493690649 | -0.0334572858246446 | 0.996717679773039 | 1 |
| P49754 | P49754 | VPS41_HUMAN | Vacuolar protein sorting-associated protein 41 homolog (S53) | VPS41 | cellular response to starvation [GO:0009267]; endosomal vesicle fusion [GO:0034058]; endosome to lysosome transport [GO:0008333]; Golgi vesicle transport [GO:0048193]; late endosome to lysosome transport [GO:1902774]; macroautophagy [GO:0016236]; protein targeting to vacuole [GO:0006623]; regulation of SNARE complex assembly [GO:0035542]; vesicle-mediated transport [GO:0016192] | clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi-associated vesicle [GO:0005798]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal HOPS complex [GO:1902501]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630] | identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017] | 7711.841973112625 | -0.169679651053929 | 0.799786367184402 | 1 |
| Q9UN37 | Q9UN37 | VPS4A_HUMAN | Vacuolar protein sorting-associated protein 4A (EC 3.6.4.6) (Protein SKD2) (VPS4-1) (hVPS4) | VPS4A | abscission [GO:0009838]; actomyosin contractile ring contraction [GO:0000916]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cell division [GO:0051301]; cytoskeleton-dependent cytokinesis [GO:0061640]; endosomal transport [GO:0016197]; endosomal vesicle fusion [GO:0034058]; ESCRT complex disassembly [GO:1904896]; ESCRT III complex disassembly [GO:1904903]; intracellular cholesterol transport [GO:0032367]; late endosomal microautophagy [GO:0061738]; late endosome to lysosome transport via multivesicular body sorting pathway [GO:0061764]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic cytokinesis checkpoint signaling [GO:0044878]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic nuclear membrane reassembly [GO:0007084]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; negative regulation of cytokinesis [GO:0032466]; nuclear envelope organization [GO:0006998]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of viral budding via host ESCRT complex [GO:1903774]; protein targeting to lysosome [GO:0006622]; regulation of protein localization [GO:0032880]; regulation of protein localization to plasma membrane [GO:1903076]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; vacuole organization [GO:0007033]; vesicle budding from membrane [GO:0006900]; vesicle uncoating [GO:0072319]; vesicle-mediated transport [GO:0016192]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076] | ATPase complex [GO:1904949]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosome [GO:0005764]; midbody [GO:0030496]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; spindle pole [GO:0000922]; vacuolar membrane [GO:0005774] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein disaggregase activity [GO:0140545]; protein-containing complex binding [GO:0044877] | 15738.8783231884 | 0.0299639082737626 | 0.983792951984958 | 1 |
| Q86Y07 | Q86Y07 | VRK2_HUMAN | Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2) | VRK2 | cellular response to oxidative stress [GO:0034599]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of interleukin-1-mediated signaling pathway [GO:2000659]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165] | cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] | ATP binding [GO:0005524]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | 2332.922385531765 | -0.211859089697611 | 0.808294544870208 | 1 |
| Q96AJ9 | Q96AJ9 | VTI1A_HUMAN | Vesicle transport through interaction with t-SNAREs homolog 1A (Vesicle transport v-SNARE protein Vti1-like 2) (Vti1-rp2) | VTI1A | autophagy [GO:0006914]; endocytic recycling [GO:0032456]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi to vacuole transport [GO:0006896]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; macroautophagy [GO:0016236]; retrograde transport, endosome to Golgi [GO:0042147]; synaptic vesicle to endosome fusion [GO:0016189]; vesicle fusion with Golgi apparatus [GO:0048280]; voluntary musculoskeletal movement [GO:0050882] | autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; trans-Golgi network membrane [GO:0032588] | SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] | 8045.614151915085 | 0.150786519299009 | 0.950536820386124 | 1 |
| P04004 | P04004 | VTNC_HUMAN | Vitronectin (VN) (S-protein) (Serum-spreading factor) (V75) [Cleaved into: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin-B] | VTN | cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; endodermal cell differentiation [GO:0035987]; extracellular matrix organization [GO:0030198]; immune response [GO:0006955]; liver regeneration [GO:0097421]; negative regulation of blood coagulation [GO:0030195]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of fibrinolysis [GO:0051918]; oligodendrocyte differentiation [GO:0048709]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein binding [GO:0032092]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; positive regulation of wound healing [GO:0090303]; protein polymerization [GO:0051258]; regulation of cell adhesion [GO:0030155]; smooth muscle cell-matrix adhesion [GO:0061302] | alphav-beta3 integrin-vitronectin complex [GO:0071062]; basement membrane [GO:0005604]; blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; intracellular membrane-bounded organelle [GO:0043231]; peptidase inhibitor complex [GO:1904090]; protein complex involved in cell-matrix adhesion [GO:0098637]; rough endoplasmic reticulum lumen [GO:0048237] | collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; polysaccharide binding [GO:0030247]; scavenger receptor activity [GO:0005044] | 118245.8498776715 | -0.00130151844630184 | 0.760450026879181 | 1 |
| Q9BTA9 | Q9BTA9 | WAC_HUMAN | WW domain-containing adapter protein with coiled-coil | WAC | chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of macroautophagy [GO:0016239]; positive regulation of TORC1 signaling [GO:1904263]; regulation of autophagy [GO:0010506] | nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] | chromatin binding [GO:0003682]; RNA polymerase II complex binding [GO:0000993] | 2363.722849956045 | -0.0547992879639681 | 0.910796553824445 | 1 |
| Q9UPY6 | Q9UPY6 | WASF3_HUMAN | Actin-binding protein WASF3 (Protein WAVE-3) (Verprolin homology domain-containing protein 3) (Wiskott-Aldrich syndrome protein family member 3) (WASP family protein member 3) | WASF3 | actin cytoskeleton organization [GO:0030036]; actin filament polymerization [GO:0030041]; cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032]; modification of postsynaptic actin cytoskeleton [GO:0098885]; oligodendrocyte development [GO:0014003]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of myelination [GO:0031643]; protein-containing complex assembly [GO:0065003]; regulation of cell shape [GO:0008360] | cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; glial cell projection [GO:0097386]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; postsynapse [GO:0098794]; SCAR complex [GO:0031209] | actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; protein kinase A regulatory subunit binding [GO:0034237] | 6111.003639126175 | 0.0394858636212642 | 0.934771423784826 | 1 |
| C4AMC7;Q6VEQ5 | C4AMC7 | WASH3_HUMAN | Putative WAS protein family homolog 3 (Protein FAM39DP) | WASH3P | Arp2/3 complex-mediated actin nucleation [GO:0034314]; early endosome to late endosome transport [GO:0045022]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; exocytosis [GO:0006887]; protein targeting to lysosome [GO:0006622]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; retrograde transport, endosome to Golgi [GO:0042147] | autophagosome [GO:0005776]; centriole [GO:0005814]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; WASH complex [GO:0071203] | actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; gamma-tubulin binding [GO:0043015] | 21535.9350600908 | -0.0389209567554146 | 0.956242759917982 | 1 |
| Q641Q2 | Q641Q2 | WAC2A_HUMAN | WASH complex subunit 2A | WASHC2A | endosomal transport [GO:0016197]; protein localization to endosome [GO:0036010]; protein transport [GO:0015031]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; retrograde transport, endosome to Golgi [GO:0042147] | cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; WASH complex [GO:0071203] | phosphatidylinositol phosphate binding [GO:1901981]; retromer complex binding [GO:1905394] | 11672.57411452055 | -0.127380853916262 | 0.723836447164009 | 1 |
| Q9Y2W2 | Q9Y2W2 | WBP11_HUMAN | WW domain-binding protein 11 (WBP-11) (Npw38-binding protein) (NpwBP) (SH3 domain-binding protein SNP70) (Splicing factor that interacts with PQBP-1 and PP1) | WBP11 | mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; rRNA processing [GO:0006364] | cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] | RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; WW domain binding [GO:0050699] | 10635.121050474001 | 0.0983425846904734 | 0.895661861152556 | 1 |
| O75083 | O75083 | WDR1_HUMAN | WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1) | WDR1 | actin filament depolymerization [GO:0030042]; actin filament fragmentation [GO:0030043]; apical junction assembly [GO:0043297]; cortical cytoskeleton organization [GO:0030865]; establishment of planar polarity of follicular epithelium [GO:0042247]; locomotion [GO:0040011]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; neutrophil mediated immunity [GO:0002446]; neutrophil migration [GO:1990266]; platelet formation [GO:0030220]; positive regulation of actin filament depolymerization [GO:0030836]; regulation of actin filament depolymerization [GO:0030834]; regulation of cell shape [GO:0008360]; regulation of oligodendrocyte differentiation [GO:0048713]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; sarcomere organization [GO:0045214]; sensory perception of sound [GO:0007605] | cell junction [GO:0030054]; cell projection [GO:0042995]; cell-cell junction [GO:0005911]; cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; podosome [GO:0002102] | actin filament binding [GO:0051015] | 231300.3541395305 | 0.0848517389813199 | 0.909094396289189 | 1 |
| Q9GZL7 | Q9GZL7 | WDR12_HUMAN | Ribosome biogenesis protein WDR12 (WD repeat-containing protein 12) | WDR12 | maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; Notch signaling pathway [GO:0007219]; regulation of cell cycle [GO:0051726]; ribosomal large subunit biogenesis [GO:0042273] | nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; PeBoW complex [GO:0070545]; preribosome, large subunit precursor [GO:0030687] | ribonucleoprotein complex binding [GO:0043021] | 11386.703404304651 | -0.058748343569149 | 0.963375603546091 | 1 |
| Q9H7D7 | Q9H7D7 | WDR26_HUMAN | WD repeat-containing protein 26 (CUL4- and DDB1-associated WDR protein 2) (Myocardial ischemic preconditioning up-regulated protein 2) | WDR26 | proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; GID complex [GO:0034657]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] | 16012.8444767334 | 0.0119619277575413 | 0.999081945878783 | 1 | |
| Q9UNX4 | Q9UNX4 | WDR3_HUMAN | WD repeat-containing protein 3 | WDR3 | maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit biogenesis [GO:0042274] | nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040] | RNA binding [GO:0003723]; snoRNA binding [GO:0030515] | 4805.6592445220795 | -0.191442429601113 | 0.927107105822222 | 1 |
| Q9Y2I8 | Q9Y2I8 | WDR37_HUMAN | WD repeat-containing protein 37 | WDR37 | corpus callosum development [GO:0022038]; lymphocyte homeostasis [GO:0002260]; mitochondrial fission [GO:0000266]; peroxisome fission [GO:0016559] | cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634] | 8551.633021157595 | -0.113916399130674 | 0.927938636139324 | 1 | |
| P57081 | P57081 | WDR4_HUMAN | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 (Protein Wuho homolog) (hWH) (WD repeat-containing protein 4) | WDR4 | DNA damage response [GO:0006974]; tRNA (guanine-N7)-methylation [GO:0106004]; tRNA modification [GO:0006400] | chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA (m7G46) methyltransferase complex [GO:0106143]; tRNA methyltransferase complex [GO:0043527] | enzyme activator activity [GO:0008047]; tRNA methyltransferase activator activity [GO:0141106] | 5185.255226001 | -0.0495251136609032 | 0.848836794763428 | 1 |
| Q5JSH3 | Q5JSH3 | WDR44_HUMAN | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | WDR44 | cytosolic ciliogenesis [GO:0061824]; negative regulation of cilium assembly [GO:1902018]; regulation of vesicle-mediated transport [GO:0060627] | cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471] | molecular sequestering activity [GO:0140313]; small GTPase binding [GO:0031267] | 21970.67390772925 | -0.0941989787691857 | 0.99947507506387 | 1 |
| Q9Y484 | Q9Y484 | WIPI4_HUMAN | WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) (WD repeat-containing protein 45) | WDR45 | autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; cellular response to starvation [GO:0009267]; glycophagy [GO:0061723]; nucleophagy [GO:0044804]; positive regulation of autophagosome assembly [GO:2000786]; protein localization to phagophore assembly site [GO:0034497] | cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045] | phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; protein kinase binding [GO:0019901] | 5171.21568991863 | -0.00441771940223798 | 0.999497386744487 | 1 |
| Q8TAF3 | Q8TAF3 | WDR48_HUMAN | WD repeat-containing protein 48 (USP1-associated factor 1) (WD repeat endosomal protein) (p80) | WDR48 | DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; embryonic organ development [GO:0048568]; homeostasis of number of cells [GO:0048872]; multicellular organism growth [GO:0035264]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; regulation of protein monoubiquitination [GO:1902525]; seminiferous tubule development [GO:0072520]; single fertilization [GO:0007338]; skeletal system morphogenesis [GO:0048705]; skin development [GO:0043588]; spermatogenesis [GO:0007283] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | deubiquitinase activator activity [GO:0035800]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; single-stranded DNA binding [GO:0003697]; ubiquitin binding [GO:0043130] | 5588.9556144128 | -0.146415179733819 | 0.745657673366656 | 1 |
| P61964 | P61964 | WDR5_HUMAN | WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein) | WDR5 | gluconeogenesis [GO:0006094]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gluconeogenesis [GO:0045722]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]; skeletal system development [GO:0001501]; transcription initiation-coupled chromatin remodeling [GO:0045815] | ATAC complex [GO:0140672]; histone acetyltransferase complex [GO:0000123]; histone methyltransferase complex [GO:0035097]; mitotic spindle [GO:0072686]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; MLL3/4 complex [GO:0044666]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188]; transcription factor TFIID complex [GO:0005669] | histone binding [GO:0042393]; histone H3K4 methyltransferase activity [GO:0042800]; methylated histone binding [GO:0035064]; RNA polymerase II general transcription initiation factor activity [GO:0016251] | 13597.628599036449 | -0.0409027189327606 | 0.992719403661119 | 1 |
| Q9H977 | Q9H977 | WDR54_HUMAN | WD repeat-containing protein 54 | WDR54 | cilium assembly [GO:0060271]; negative regulation of receptor internalization [GO:0002091]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of MAPK cascade [GO:0043408] | axoneme [GO:0005930]; intracellular membrane-bounded organelle [GO:0043231]; vesicle [GO:0031982] | protein homodimerization activity [GO:0042803] | 4379.609652848725 | 0.0371311985592509 | 0.957205097712656 | 1 |
| Q9H6Y2 | Q9H6Y2 | WDR55_HUMAN | WD repeat-containing protein 55 | WDR55 | rRNA processing [GO:0006364] | cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] | 6215.89405399334 | 0.073776088158112 | 0.800184682877088 | 1 | |
| Q9NNW5 | Q9NNW5 | WDR6_HUMAN | tRNA (34-2'-O)-methyltransferase regulator WDR6 (WD repeat-containing protein 6) | WDR6 | G1 to G0 transition [GO:0070314]; negative regulation of autophagy [GO:0010507]; negative regulation of cell population proliferation [GO:0008285]; tRNA methylation [GO:0030488]; wobble position ribose methylation [GO:0002130] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] | enzyme regulator activity [GO:0030234]; RNA binding [GO:0003723]; tRNA binding [GO:0000049] | 3205.03545463433 | -0.177700737022281 | 0.936677561501178 | 1 |
| Q9Y4E6 | Q9Y4E6 | WDR7_HUMAN | WD repeat-containing protein 7 (Rabconnectin-3 beta) (TGF-beta resistance-associated protein TRAG) | WDR7 | hematopoietic progenitor cell differentiation [GO:0002244] | cytoplasm [GO:0005737] | 3770.2072703580598 | 0.0427306027133373 | 0.869478107450411 | 1 | |
| Q6UXN9 | Q6UXN9 | WDR82_HUMAN | WD repeat-containing protein 82 | WDR82 | DNA-templated transcription termination [GO:0006353]; lncRNA catabolic process [GO:0110064]; negative regulation of DNA-templated transcription, elongation [GO:0032785]; negative regulation of lncRNA transcription [GO:0140744]; nuclear RNA surveillance [GO:0071027] | chromatin [GO:0000785]; histone methyltransferase complex [GO:0035097]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; PTW/PP1 phosphatase complex [GO:0072357]; Set1C/COMPASS complex [GO:0048188] | chromatin binding [GO:0003682] | 13314.952498622199 | -0.0187659961863968 | 0.999871066028427 | 1 |
| Q5MNZ9 | Q5MNZ9 | WIPI1_HUMAN | WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1) (Atg18 protein homolog) (WD40 repeat protein interacting with phosphoinositides of 49 kDa) (WIPI 49 kDa) | WIPI1 | autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; cellular response to starvation [GO:0009267]; glycophagy [GO:0061723]; nucleophagy [GO:0044804]; positive regulation of autophagosome assembly [GO:2000786]; protein localization to phagophore assembly site [GO:0034497]; vesicle targeting, trans-Golgi to endosome [GO:0048203] | autophagosome membrane [GO:0000421]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extrinsic component of membrane [GO:0019898]; Golgi membrane [GO:0000139]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; trans-Golgi network [GO:0005802] | nuclear androgen receptor binding [GO:0050681]; nuclear estrogen receptor binding [GO:0030331]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor binding [GO:0005102] | 15833.8608997124 | -0.0629280202944209 | 0.979789884471221 | 1 |
| Q9H4A3 | Q9H4A3 | WNK1_HUMAN | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | WNK1 | cell volume homeostasis [GO:0006884]; cellular hyperosmotic response [GO:0071474]; cellular response to chemokine [GO:1990869]; chemokine (C-C motif) ligand 21 signaling pathway [GO:0038116]; heart development [GO:0007507]; intracellular chloride ion homeostasis [GO:0030644]; intracellular signal transduction [GO:0035556]; lymphocyte migration into lymph node [GO:0097022]; monoatomic cation homeostasis [GO:0055080]; monoatomic ion transport [GO:0006811]; negative regulation of autophagy [GO:0010507]; negative regulation of cell-cell adhesion mediated by integrin [GO:0033633]; negative regulation of GTPase activity [GO:0034260]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of leukocyte cell-cell adhesion [GO:1903038]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of sodium ion transport [GO:0010766]; neuron development [GO:0048666]; non-membrane-bounded organelle assembly [GO:0140694]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of angiogenesis [GO:0045766]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of mitotic cytokinesis [GO:1903490]; positive regulation of potassium ion import across plasma membrane [GO:1903288]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of termination of RNA polymerase II transcription [GO:1904595]; potassium ion homeostasis [GO:0055075]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; protein phosphorylation [GO:0006468]; regulation of monoatomic cation transmembrane transport [GO:1904062]; regulation of mRNA export from nucleus [GO:0010793]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of sodium ion transport [GO:0002028]; signal transduction [GO:0007165]; sodium ion transmembrane transport [GO:0035725]; T cell receptor signaling pathway [GO:0050852] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular non-membrane-bounded organelle [GO:0043232]; membrane [GO:0016020]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] | ATP binding [GO:0005524]; molecular condensate scaffold activity [GO:0140693]; phosphatase binding [GO:0019902]; potassium channel inhibitor activity [GO:0019870]; protein kinase activator activity [GO:0030295]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | 14033.38018674055 | -0.0338996615652701 | 0.999999989471506 | 1 |
| Q6AWC2 | Q6AWC2 | WWC2_HUMAN | Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2) | WWC2 | cell migration [GO:0016477]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hippo signaling [GO:0035331]; negative regulation of organ growth [GO:0046621]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of hippo signaling [GO:0035330] | cytoplasm [GO:0005737]; cytosol [GO:0005829] | kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090] | 4413.822485751594 | -0.00509749920447242 | 0.909885223339163 | 1 |
| Q9GZV5 | Q9GZV5 | WWTR1_HUMAN | WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif) | WWTR1 | cilium assembly [GO:0060271]; glomerulus development [GO:0032835]; heart process [GO:0003015]; hippo signaling [GO:0035329]; kidney morphogenesis [GO:0060993]; mesenchymal cell differentiation [GO:0048762]; multicellular organism growth [GO:0035264]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; regulation of DNA-templated transcription [GO:0006355]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; SMAD protein signal transduction [GO:0060395]; stem cell division [GO:0017145]; tissue homeostasis [GO:0001894] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667] | protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] | 15062.7171608178 | -0.0212522003411434 | 0.966382635979139 | 1 |
| Q9HCS7 | Q9HCS7 | SYF1_HUMAN | Pre-mRNA-splicing factor SYF1 (Protein HCNP) (XPA-binding protein 2) | XAB2 | blastocyst development [GO:0001824]; DNA-templated transcription [GO:0006351]; generation of catalytic spliceosome for first transesterification step [GO:0000349]; mRNA splicing, via spliceosome [GO:0000398]; transcription-coupled nucleotide-excision repair [GO:0006283] | catalytic step 2 spliceosome [GO:0071013]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; Prp19 complex [GO:0000974]; U2-type catalytic step 2 spliceosome [GO:0071007] | 10322.81969347435 | 0.142869398979968 | 0.994268547728167 | 1 | |
| P55808 | P55808 | XG_HUMAN | Glycoprotein Xg (Protein PBDX) | XG | homotypic cell-cell adhesion [GO:0034109]; positive regulation of neutrophil extravasation [GO:2000391]; T cell extravasation [GO:0072683] | plasma membrane [GO:0005886] | 25155.54388637245 | -0.0142309007651008 | 0.998806384697815 | 1 | |
| P98170 | P98170 | XIAP_HUMAN | E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP) | XIAP | copper ion homeostasis [GO:0055070]; defense response to bacterium [GO:0042742]; DNA damage response [GO:0006974]; inhibition of cysteine-type endopeptidase activity [GO:0097340]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; neuron apoptotic process [GO:0051402]; nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070427]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein linear polyubiquitination [GO:1902530]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of type I interferon production [GO:0032481]; protein K63-linked ubiquitination [GO:0070534]; regulation of apoptosis involved in tissue homeostasis [GO:0060785]; regulation of apoptotic process [GO:0042981]; regulation of BMP signaling pathway [GO:0030510]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of inflammatory response [GO:0050727]; regulation of innate immune response [GO:0045088]; regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0070424]; Wnt signaling pathway [GO:0016055] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | cysteine-type endopeptidase inhibitor activity [GO:0004869]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; endopeptidase regulator activity [GO:0061135]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein serine/threonine kinase binding [GO:0120283]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] | 8849.6678128081 | 0.122627805996772 | 0.965839557315085 | 1 |
| Q96QU8 | Q96QU8 | XPO6_HUMAN | Exportin-6 (Exp6) (Ran-binding protein 20) | XPO6 | protein export from nucleus [GO:0006611] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] | nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267] | 1799.10546336822 | -0.373179862348885 | 0.85329737139164 | 1 |
| P18887 | P18887 | XRCC1_HUMAN | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | XRCC1 | base-excision repair [GO:0006284]; cerebellum morphogenesis [GO:0021587]; double-strand break repair via nonhomologous end joining [GO:0006303]; hippocampus development [GO:0021766]; negative regulation of protection from non-homologous end joining at telomere [GO:1905765]; negative regulation of protein ADP-ribosylation [GO:0010836]; positive regulation of DNA ligase activity [GO:1904877]; positive regulation of single strand break repair [GO:1903518]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414]; response to hydroperoxide [GO:0033194]; response to hypoxia [GO:0001666]; response to organic substance [GO:0010033]; response to xenobiotic stimulus [GO:0009410]; single strand break repair [GO:0000012]; telomeric DNA-containing double minutes formation [GO:0061819]; voluntary musculoskeletal movement [GO:0050882] | chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; ERCC4-ERCC1 complex [GO:0070522]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734] | 3' overhang single-stranded DNA endodeoxyribonuclease activity [GO:1990599]; ADP-D-ribose modification-dependent protein binding [GO:0160002]; enzyme binding [GO:0019899]; oxidized DNA binding [GO:0032356]; poly-ADP-D-ribose binding [GO:0072572] | 5678.062311679865 | -0.112759153893585 | 0.840095105292679 | 1 |
| Q13426 | Q13426 | XRCC4_HUMAN | DNA repair protein XRCC4 (hXRCC4) (X-ray repair cross-complementing protein 4) [Cleaved into: Protein XRCC4, C-terminus (XRCC4/C)] | XRCC4 | cellular response to lithium ion [GO:0071285]; DNA ligation involved in DNA repair [GO:0051103]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; immunoglobulin V(D)J recombination [GO:0033152]; positive regulation of ligase activity [GO:0051351]; protein localization to site of double-strand break [GO:1990166]; response to X-ray [GO:0010165] | cytosol [GO:0005829]; DNA ligase IV complex [GO:0032807]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; nonhomologous end joining complex [GO:0070419]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] | FHA domain binding [GO:0070975]; identical protein binding [GO:0042802] | 7030.296764504255 | -0.0833473047854184 | 0.907983944213107 | 1 |
| P13010 | P13010 | XRCC5_HUMAN | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | XRCC5 | activation of innate immune response [GO:0002218]; cellular hyperosmotic salinity response [GO:0071475]; cellular response to fatty acid [GO:0071398]; cellular response to gamma radiation [GO:0071480]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to X-ray [GO:0071481]; DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; hematopoietic stem cell differentiation [GO:0060218]; hematopoietic stem cell proliferation [GO:0071425]; innate immune response [GO:0045087]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of t-circle formation [GO:1904430]; neurogenesis [GO:0022008]; positive regulation of catalytic activity [GO:0043085]; positive regulation of neurogenesis [GO:0050769]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein localization to chromosome, telomeric region [GO:0070198]; recombinational repair [GO:0000725]; regulation of smooth muscle cell proliferation [GO:0048660]; regulation of telomere maintenance [GO:0032204]; response to xenobiotic stimulus [GO:0009410]; small-subunit processome assembly [GO:0034462]; telomere maintenance [GO:0000723] | chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; DNA-dependent protein kinase complex [GO:0070418]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; extracellular region [GO:0005576]; Ku70:Ku80 complex [GO:0043564]; membrane [GO:0016020]; nonhomologous end joining complex [GO:0070419]; nuclear telomere cap complex [GO:0000783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; ribonucleoprotein complex [GO:1990904]; secretory granule lumen [GO:0034774]; site of DNA damage [GO:0090734]; small-subunit processome [GO:0032040] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA end binding [GO:0045027]; DNA helicase activity [GO:0003678]; double-stranded DNA binding [GO:0003690]; enzyme activator activity [GO:0008047]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162]; transcription cis-regulatory region binding [GO:0000976]; U3 snoRNA binding [GO:0034511]; ubiquitin protein ligase binding [GO:0031625] | 35208.948650166945 | -0.0123019451463892 | 1 | 1 |
| P12956 | P12956 | XRCC6_HUMAN | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | XRCC6 | activation of innate immune response [GO:0002218]; cellular hyperosmotic salinity response [GO:0071475]; cellular response to gamma radiation [GO:0071480]; cellular response to X-ray [GO:0071481]; DNA ligation [GO:0006266]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; double-strand break repair via nonhomologous end joining [GO:0006303]; innate immune response [GO:0045087]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of lymphocyte differentiation [GO:0045621]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of transcription by RNA polymerase II [GO:0045944]; recombinational repair [GO:0000725]; regulation of smooth muscle cell proliferation [GO:0048660]; telomere maintenance [GO:0000723] | chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; DNA-dependent protein kinase complex [GO:0070418]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Ku70:Ku80 complex [GO:0043564]; membrane [GO:0016020]; nonhomologous end joining complex [GO:0070419]; nuclear telomere cap complex [GO:0000783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; secretory granule lumen [GO:0034774]; transcription regulator complex [GO:0005667] | 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; cyclin binding [GO:0030332]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; double-stranded DNA binding [GO:0003690]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]; telomeric DNA binding [GO:0042162]; transcription cis-regulatory region binding [GO:0000976] | 77402.41553869755 | 0.0518235462276265 | 0.999759417007497 | 1 |
| Q9H1B5 | Q9H1B5 | XYLT2_HUMAN | Xylosyltransferase 2 (EC 2.4.2.26) (Peptide O-xylosyltransferase 1) (Xylosyltransferase II) (XT-II) (XylT-II) | XYLT2 | chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan metabolic process [GO:0030203]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparin biosynthetic process [GO:0030210] | extracellular space [GO:0005615]; Golgi membrane [GO:0000139] | magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein xylosyltransferase activity [GO:0030158] | 4479.861522804605 | 0.164137591069874 | 0.723796700135068 | 1 |
| P16989 | P16989 | YBOX3_HUMAN | Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB) | YBX3 | 3'-UTR-mediated mRNA stabilization [GO:0070935]; apoptotic process [GO:0006915]; cellular hyperosmotic response [GO:0071474]; cellular response to tumor necrosis factor [GO:0071356]; ectopic germ cell programmed cell death [GO:0035234]; fertilization [GO:0009566]; in utero embryonic development [GO:0001701]; male gonad development [GO:0008584]; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [GO:1902219]; negative regulation of necroptotic process [GO:0060546]; negative regulation of reproductive process [GO:2000242]; negative regulation of skeletal muscle tissue development [GO:0048642]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of organ growth [GO:0046622]; regulation of gene expression [GO:0010468]; spermatogenesis [GO:0007283] | bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; synapse [GO:0045202] | mRNA 3'-UTR binding [GO:0003730]; nucleic acid binding [GO:0003676]; polysome binding [GO:1905538]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; small GTPase binding [GO:0031267] | 69830.85020110125 | 0.151458935498675 | 0.893396158115287 | 1 |
| P07947 | P07947 | YES_HUMAN | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) | YES1 | cell differentiation [GO:0030154]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; ephrin receptor signaling pathway [GO:0048013]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; innate immune response [GO:0045087]; leukocyte migration [GO:0050900]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; phosphorylation [GO:0016310]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein modification process [GO:0036211]; regulation of glucose transmembrane transport [GO:0010827]; regulation of vascular permeability [GO:0043114]; T cell costimulation [GO:0031295]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] | actin filament [GO:0005884]; centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] | ATP binding [GO:0005524]; enzyme binding [GO:0019899]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphotyrosine residue binding [GO:0001784]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325] | 22900.965054850552 | 0.0125564935065618 | 0.999761384581133 | 1 |
| Q9GZM5 | Q9GZM5 | YIPF3_HUMAN | Protein YIPF3 (Killer lineage protein 1) (Natural killer cell-specific antigen KLIP1) (YIP1 family member 3) [Cleaved into: Protein YIPF3, 36 kDa form III] | YIPF3 | cell differentiation [GO:0030154] | Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133] | 26544.15949170005 | -0.00161862751380251 | 0.999999916003861 | 1 | |
| P49750 | P49750 | YLPM1_HUMAN | YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113) | YLPM1 | regulation of telomere maintenance [GO:0032204] | nuclear speck [GO:0016607]; nucleus [GO:0005634] | RNA binding [GO:0003723] | 8180.334057412005 | -0.153459111851692 | 0.959640430166129 | 1 |
| Q96MU7 | Q96MU7 | YTDC1_HUMAN | YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) | YTHDC1 | dosage compensation by inactivation of X chromosome [GO:0009048]; in utero embryonic development [GO:0001701]; mRNA alternative polyadenylation [GO:0110104]; mRNA export from nucleus [GO:0006406]; mRNA splice site recognition [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; post-transcriptional regulation of gene expression [GO:0010608]; primary follicle stage [GO:0048160]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA splicing, via spliceosome [GO:0048024]; spermatogenesis [GO:0007283] | nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; RNA binding [GO:0003723] | 15513.25866264985 | -0.0209759958436762 | 0.954018337420743 | 1 |
| Q9Y5A9 | Q9Y5A9 | YTHD2_HUMAN | YTH domain-containing family protein 2 (DF2) (CLL-associated antigen KW-14) (High-glucose-regulated protein 8) (Renal carcinoma antigen NY-REN-2) | YTHDF2 | cell cycle [GO:0007049]; embryonic morphogenesis [GO:0048598]; endothelial to hematopoietic transition [GO:0098508]; gamete generation [GO:0007276]; hematopoietic stem cell proliferation [GO:0071425]; humoral immune response [GO:0006959]; innate immune response [GO:0045087]; mRNA catabolic process [GO:0006402]; mRNA destabilization [GO:0061157]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; oocyte maturation [GO:0001556]; organelle assembly [GO:0070925]; positive regulation of cap-independent translational initiation [GO:1903679]; regulation of cell adhesion [GO:0030155]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of meiotic cell cycle process involved in oocyte maturation [GO:1903538]; regulation of mRNA stability [GO:0043488]; regulation of neurogenesis [GO:0050767]; regulation of rRNA processing [GO:2000232]; spermatogonial cell division [GO:0007284]; stress granule assembly [GO:0034063] | centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932] | C5-methylcytidine-containing RNA reader activity [GO:0062153]; mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; RNA binding [GO:0003723] | 25838.21334251545 | -0.0140986078071953 | 0.999423953038336 | 1 |
| O75152 | O75152 | ZC11A_HUMAN | Zinc finger CCCH domain-containing protein 11A | ZC3H11A | poly(A)+ mRNA export from nucleus [GO:0016973] | nucleoplasm [GO:0005654] | metal ion binding [GO:0046872]; RNA binding [GO:0003723] | 2779.449885207785 | 0.0364221782606048 | 0.995077364709515 | 1 |
| Q86VM9 | Q86VM9 | ZCH18_HUMAN | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | ZC3H18 | RNA destabilization [GO:0050779] | nuclear speck [GO:0016607]; precatalytic spliceosome [GO:0071011]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904] | metal ion binding [GO:0046872]; mRNA cap binding complex binding [GO:0140262]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723] | 6967.56994158859 | 0.17076241102969 | 0.811770604835338 | 1 |
| Q9UPT8 | Q9UPT8 | ZC3H4_HUMAN | Zinc finger CCCH domain-containing protein 4 | ZC3H4 | DNA-templated transcription termination [GO:0006353]; lncRNA catabolic process [GO:0110064]; negative regulation of DNA-templated transcription, elongation [GO:0032785]; negative regulation of lncRNA transcription [GO:0140744]; nuclear RNA surveillance [GO:0071027] | chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; RNA binding [GO:0003723] | 5500.94709476165 | -0.0848888011631353 | 0.842046262545081 | 1 |
| Q8IWR0 | Q8IWR0 | Z3H7A_HUMAN | Zinc finger CCCH domain-containing protein 7A | ZC3H7A | miRNA processing [GO:0035196]; post-transcriptional regulation of gene expression [GO:0010608] | nucleus [GO:0005634] | metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA binding [GO:0003723] | 4754.17276934854 | -0.0597866790503536 | 0.935121026380083 | 1 |
| Q9UGR2 | Q9UGR2 | Z3H7B_HUMAN | Zinc finger CCCH domain-containing protein 7B (Rotavirus 'X'-associated non-structural protein) (RoXaN) | ZC3H7B | miRNA processing [GO:0035196]; post-transcriptional regulation of gene expression [GO:0010608] | nucleus [GO:0005634] | metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA binding [GO:0003723] | 9207.741300642325 | -0.0450059695414112 | 0.915095873563636 | 1 |
| Q96H79 | Q96H79 | ZCCHL_HUMAN | Zinc finger CCCH-type antiviral protein 1-like | ZC3HAV1L | cytosol [GO:0005829] | 13394.7086525212 | -0.0389194010013667 | 0.934832402448084 | 1 | ||
| Q6NZY4 | Q6NZY4 | ZCHC8_HUMAN | Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8) | ZCCHC8 | mRNA splicing, via spliceosome [GO:0000398]; ncRNA processing [GO:0034470]; snRNA catabolic process [GO:0016076] | catalytic step 2 spliceosome [GO:0071013]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TRAMP complex [GO:0031499] | RNA binding [GO:0003723]; zinc ion binding [GO:0008270] | 7362.76723819697 | -0.0661681371680636 | 0.98816275610326 | 1 |
| Q8IUH4 | Q8IUH4 | ZDH13_HUMAN | Palmitoyltransferase ZDHHC13 (EC 2.3.1.225) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein) (Huntingtin-interacting protein HIP3RP) (Putative MAPK-activating protein PM03) (Putative NF-kappa-B-activating protein 209) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) | ZDHHC13 | positive regulation of canonical NF-kappaB signal transduction [GO:0043123] | endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; membrane [GO:0016020] | magnesium ion transmembrane transporter activity [GO:0015095]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706] | 8793.336354623181 | 0.191870429474293 | 0.905846723280132 | 1 |
| Q8IUH5 | Q8IUH5 | ZDH17_HUMAN | Palmitoyltransferase ZDHHC17 (EC 2.3.1.225) (Acyltransferase ZDHHC17) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 17) (DHHC17) (Huntingtin yeast partner H) (Huntingtin-interacting protein 14) (HIP-14) (Huntingtin-interacting protein 3) (HIP-3) (Huntingtin-interacting protein H) (Putative MAPK-activating protein PM11) (Putative NF-kappa-B-activating protein 205) (Zinc finger DHHC domain-containing protein 17) | ZDHHC17 | axonogenesis [GO:0007409]; lipoprotein transport [GO:0042953]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein palmitoylation [GO:0018345]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of neurotrophin TRK receptor signaling pathway [GO:0051386]; regulation of programmed cell death [GO:0043067] | cell projection [GO:0042995]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; intracellular membrane-bounded organelle [GO:0043231]; presynaptic membrane [GO:0042734] | identical protein binding [GO:0042802]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-myristoyltransferase activity [GO:0019705]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439]; signaling receptor binding [GO:0005102] | 4546.589377558919 | -0.154207270582852 | 0.726398166449718 | 1 |
| Q5W0Z9 | Q5W0Z9 | ZDH20_HUMAN | Palmitoyltransferase ZDHHC20 (EC 2.3.1.225) (Acyltransferase ZDHHC20) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 20) (DHHC20) (Zinc finger DHHC domain-containing protein 20) | ZDHHC20 | peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation by host of viral process [GO:0044794]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]; synaptic vesicle maturation [GO:0016188] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] | palmitoyltransferase activity [GO:0016409]; protein-cysteine S-myristoyltransferase activity [GO:0019705]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439]; zinc ion binding [GO:0008270] | 7769.126613771499 | 0.00667695420213023 | 0.994945247370501 | 1 |
| Q9HBF4 | Q9HBF4 | ZFYV1_HUMAN | Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (SR3) (Tandem FYVE fingers-1) | ZFYVE1 | cellular response to starvation [GO:0009267]; lipid droplet formation [GO:0140042]; macroautophagy [GO:0016236]; positive regulation by host of viral genome replication [GO:0044829] | autophagosome [GO:0005776]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extrinsic component of omegasome membrane [GO:0097629]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; lipid droplet [GO:0005811]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrion [GO:0005739]; omegasome [GO:1990462]; perinuclear region of cytoplasm [GO:0048471]; phagophore assembly site [GO:0000407] | 1-phosphatidylinositol binding [GO:0005545]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3-phosphate binding [GO:0032266]; zinc ion binding [GO:0008270] | 4631.18567433371 | -0.224524952244004 | 0.841401249613139 | 1 |
| Q9BQ24 | Q9BQ24 | ZFY21_HUMAN | Zinc finger FYVE domain-containing protein 21 (ZF21) | ZFYVE21 | endosome [GO:0005768]; focal adhesion [GO:0005925] | metal ion binding [GO:0046872] | 5871.779356117255 | -0.01927054172208 | 0.991383521515609 | 1 | |
| Q9ULU4 | Q9ULU4 | ZMYD8_HUMAN | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | ZMYND8 | chromatin organization [GO:0006325]; double-strand break repair via homologous recombination [GO:0000724]; modulation of excitatory postsynaptic potential [GO:0098815]; negative regulation of cell migration [GO:0030336]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of dendritic spine maintenance [GO:1902952]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; protein localization to chromatin [GO:0071168]; regulation of postsynaptic density protein 95 clustering [GO:1902897] | chromatin [GO:0000785]; cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734] | DNA-binding transcription factor binding [GO:0140297]; lysine-acetylated histone binding [GO:0070577]; methylated histone binding [GO:0035064]; protein domain specific binding [GO:0019904]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270] | 2771.178279941465 | 0.130500538252074 | 0.891396183905182 | 1 |
| Q9UQR1 | Q9UQR1 | ZN148_HUMAN | Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) | ZNF148 | cellular defense response [GO:0006968]; gamete generation [GO:0007276]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; substantia nigra development [GO:0021762] | Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654] | DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565] | 2757.932285190755 | 4.01586409417709 | 0.77407598666789 | 1 |
| O15231 | O15231 | ZN185_HUMAN | Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A) | ZNF185 | cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925] | zinc ion binding [GO:0008270] | 15811.937283447649 | 0.0399255506587555 | 0.99999989232689 | 1 | |
| O43670 | O43670 | ZN207_HUMAN | BUB3-interacting and GLEBS motif-containing protein ZNF207 (BuGZ) (hBuGZ) (Zinc finger protein 207) | ZNF207 | attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; microtubule bundle formation [GO:0001578]; microtubule polymerization [GO:0046785]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly [GO:0090307]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein stabilization [GO:0050821]; regulation of chromosome segregation [GO:0051983] | cytoplasm [GO:0005737]; kinetochore [GO:0000776]; microtubule [GO:0005874]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle matrix [GO:1990047] | DNA binding [GO:0003677]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; RNA binding [GO:0003723] | 33756.5498915787 | 0.00823156005548081 | 0.999486020445807 | 1 |
| Q9Y3S2 | Q9Y3S2 | ZN330_HUMAN | Zinc finger protein 330 (Nucleolar autoantigen 36) (Nucleolar cysteine-rich protein) | ZNF330 | chromosome, centromeric region [GO:0000775]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | metal ion binding [GO:0046872]; zinc ion binding [GO:0008270] | 1554.4750982503951 | -0.800416623559587 | 0.959154586342084 | 1 | |
| Q9UL40 | Q9UL40 | ZN346_HUMAN | Zinc finger protein 346 (Just another zinc finger protein) | ZNF346 | cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] | 9835.119585035536 | 0.122560615606759 | 0.70831561944284 | 1 | |
| Q86UK7 | Q86UK7 | ZN598_HUMAN | E3 ubiquitin-protein ligase ZNF598 (EC 2.3.2.27) (Zinc finger protein 598) | ZNF598 | negative regulation of translational initiation [GO:0045947]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; rescue of stalled ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116] | cytosol [GO:0005829]; cytosolic ribosome [GO:0022626] | metal ion binding [GO:0046872]; protein-RNA adaptor activity [GO:0140517]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; stalled ribosome sensor activity [GO:0170011]; ubiquitin protein ligase activity [GO:0061630] | 11130.8094344933 | 0.0773007088139325 | 0.967035115338408 | 1 |
| Q5JTY5;Q5RIA9;Q9BRT8 | Q5JTY5 | ZNG1C_HUMAN | Zinc-regulated GTPase metalloprotein activator 1C (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 3) (COBW domain-containing protein 3) | ZNG1C | cytoplasm [GO:0005737]; nucleus [GO:0005634] | GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872] | 6885.430290619344 | 0.0604363488740113 | 0.836644346505963 | 1 | |
| O43264 | O43264 | ZW10_HUMAN | Centromere/kinetochore protein zw10 homolog | ZW10 | cell division [GO:0051301]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; establishment of mitotic spindle orientation [GO:0000132]; Golgi organization [GO:0007030]; meiotic cell cycle [GO:0051321]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore [GO:0034501]; protein transport [GO:0015031]; protein-containing complex assembly [GO:0065003]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of exit from mitosis [GO:0007096]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890] | cytosol [GO:0005829]; Dsl1/NZR complex [GO:0070939]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nucleus [GO:0005634]; RZZ complex [GO:1990423]; spindle pole [GO:0000922] | centromeric DNA binding [GO:0019237] | 9872.204333672806 | -0.0757557365854165 | 0.998432455960071 | 1 |
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| Q15149 | |||||||||
| Q99715 | |||||||||
| P02452 | |||||||||
| P02751 | |||||||||
| P98160 | |||||||||
| P08123 | |||||||||
| P02461 | |||||||||
| P07996 | |||||||||
| Q8WWI1 | |||||||||
| P05997 | |||||||||
| P20908 | |||||||||
| Q8WUJ3 | |||||||||
| P21333 | |||||||||
| O75369 | |||||||||
| Q15063 | |||||||||
| P02786 | |||||||||
| Q12884 | |||||||||
| P12814 | |||||||||
| Q9UDY2 | |||||||||
| Q14195 | |||||||||
| Q02952 | |||||||||
| Q9NZM1 | |||||||||
| P35579 | |||||||||
| P35354 | |||||||||
| P47895 | |||||||||
| Q09666 | |||||||||
| P11717 | |||||||||
| Q14112 | |||||||||
| Q13620 | |||||||||
| P43490 | |||||||||
| Q3SY69 | |||||||||
| P17812 | |||||||||
| P21980 | |||||||||
| Q16647 | |||||||||
| P01024 | |||||||||
| Q5SW79 | |||||||||
| P06396 | |||||||||
| P12111 | |||||||||
| P35221 | |||||||||
| P12429 | |||||||||
| P78559 | |||||||||
| Q76M96 | |||||||||
| Q16881 | |||||||||
| P07093 | |||||||||
| P27487 | |||||||||
| P15144 | |||||||||
| Q9H5V8 | |||||||||
| P08729 | |||||||||
| Q04828 | |||||||||
| O94925 | |||||||||
| P08473 | |||||||||
| Q8IVL5 | |||||||||
| P35442 | |||||||||
| O60716 | |||||||||
| P08253 | |||||||||
| Q16822 | |||||||||
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| Q32MZ4 | |||||||||
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| P48681 | |||||||||
| O95340 | |||||||||
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| Q00341 | |||||||||
| P49748 | |||||||||
| O43854 | |||||||||
| P07942 | |||||||||
| Q96KC8 | |||||||||
| Q96PD2 | |||||||||
| Q13418 | |||||||||
| Q7Z7G0 | |||||||||
| Q04446 | |||||||||
| P19022 | |||||||||
| O00469 | |||||||||
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| Q14767 | |||||||||
| Q13308 | |||||||||
| P46940 | |||||||||
| Q9NZ08 | |||||||||
| O60488 | |||||||||
| P35222 | |||||||||
| Q9H4M9 | |||||||||
| Q9NZU5 | |||||||||
| Q15113 | |||||||||
| O94808 | |||||||||
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| Q05682 | |||||||||
| P17342 | |||||||||
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| Q9NR12 | |||||||||
| P05362 | |||||||||
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| P05120 | |||||||||
| P15121 | |||||||||
| P04179 | |||||||||
| Q15785 | |||||||||
| O60271 | |||||||||
| Q9Y6N5 | |||||||||
| Q9P0V9 | |||||||||
| Q8IVF2 | |||||||||
| P01584 | |||||||||
| Q96AQ6 | |||||||||
| P54289 | |||||||||
| P13667 | |||||||||
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| P21810 | |||||||||
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| O95490 | |||||||||
| Q16222 | |||||||||
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| P08133 | |||||||||
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| P49419 | |||||||||
| P41252 | |||||||||
| P50281 | |||||||||
| Q13618 | |||||||||
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| Q9BZG1 | |||||||||
| P11142 | |||||||||
| P63010 | |||||||||
| Q9UBG0 | |||||||||
| Q5GLZ8 | |||||||||
| P21266 | |||||||||
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| P35232 | |||||||||
| Q86VP6 | |||||||||
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| Q16851 | |||||||||
| P28845 | |||||||||
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| P23381 | |||||||||
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| P98155 | |||||||||
| P46977 | |||||||||
| Q86SQ0 | |||||||||
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| P50452 | |||||||||
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| O00116 |
