Summary statistics - differenital analysis

Selected Cell

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stat_data__min_2_Peptides Sheet1

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Q9BYG3	Q9BYG3	MK67I_HUMAN	MKI67 FHA domain-interacting nucleolar phosphoprotein (Nucleolar phosphoprotein Nopp34) (Nucleolar protein interacting with the FHA domain of pKI-67) (hNIFK)	NIFK	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; protein-containing complex assembly [GO:0065003]; rRNA metabolic process [GO:0016072]; rRNA transcription [GO:0009303]	chromosome [GO:0005694]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]	17105.401011293798	0.0328372894316401	0.973844704385052	1
Q9BPW8	Q9BPW8	NIPS1_HUMAN	Protein NipSnap homolog 1 (NipSnap1)	NIPSNAP1	sensory perception of pain [GO:0019233]	mitochondrion [GO:0005739]; synaptic membrane [GO:0097060]		31368.2277363241	0.0596585740747224	0.992731574966006	1
O75323	O75323	NIPS2_HUMAN	Protein NipSnap homolog 2 (NipSnap2) (Glioblastoma-amplified sequence)	NIPSNAP2	mitochondrion organization [GO:0007005]; oxidative phosphorylation [GO:0006119]; positive regulation of high voltage-gated calcium channel activity [GO:1901843]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]		17215.15309137335	-0.0343587384500127	0.999457890268032	1
Q9UFN0	Q9UFN0	NPS3A_HUMAN	Protein NipSnap homolog 3A (NipSnap3A) (Protein NipSnap homolog 4) (NipSnap4) (Target for Salmonella secreted protein C) (TassC)	NIPSNAP3A		cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]		34062.2948109104	0.205336685772707	0.658439435615486	1
Q9Y2I1	Q9Y2I1	NISCH_HUMAN	Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor antisera-selected protein) (hIRAS) (Imidazoline-1 receptor) (I1R) (Imidazoline-1 receptor candidate protein) (I-1 receptor candidate protein) (I1R candidate protein)	NISCH	actin cytoskeleton organization [GO:0030036]; apoptotic process [GO:0006915]; negative regulation of cell migration [GO:0030336]; outer dynein arm assembly [GO:0036158]; Rac protein signal transduction [GO:0016601]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]	alpha-tubulin binding [GO:0043014]; dynein heavy chain binding [GO:0045504]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; phosphatidylinositol binding [GO:0035091]	4790.99063986717	0.00710653280789601	0.997948566666434	1
O15226	O15226	NKRF_HUMAN	NF-kappa-B-repressing factor (NFkB-repressing factor) (NRF) (Protein ITBA4)	NKRF	negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATPase activator activity [GO:0001671]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	5668.262396829776	-0.0883867913204191	0.773740666307158	1
P30414	P30414	NKTR_HUMAN	NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase)	NKTR	protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	25864.6106159484	0.113632062270185	0.707946896560286	1
Q9NVX2	Q9NVX2	NLE1_HUMAN	Notchless protein homolog 1	NLE1	hematopoietic stem cell homeostasis [GO:0061484]; inner cell mass cell differentiation [GO:0001826]; kidney development [GO:0001822]; mitotic cell cycle [GO:0000278]; negative regulation of mitotic cell cycle [GO:0045930]; Notch signaling pathway [GO:0007219]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; ribosomal large subunit biogenesis [GO:0042273]; skeletal system morphogenesis [GO:0048705]; somitogenesis [GO:0001756]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]		14666.4548812497	0.00584098979244981	0.999830998538012	1
Q9Y5B8	Q9Y5B8	NDK7_HUMAN	Nucleoside diphosphate kinase homolog 7 (NDK 7) (NDP kinase homolog 7) (3'-5' exonuclease NME7) (EC 3.1.-.-) (Protein kinase NME7) (EC 2.7.-.-) (nm23-H7)	NME7	CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; phosphorylation [GO:0016310]; regulation of microtubule nucleation [GO:0010968]; UTP biosynthetic process [GO:0006228]	axonemal microtubule [GO:0005879]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; gamma-tubulin ring complex [GO:0000931]; motile cilium [GO:0031514]; nucleus [GO:0005634]; spindle [GO:0005819]	3'-5' exonuclease activity [GO:0008408]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]	4395.08224029576	-0.136046053466529	0.930359743155448	1
Q9HBL8	Q9HBL8	NMRL1_HUMAN	NmrA-like family domain-containing protein 1	NMRAL1		cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	identical protein binding [GO:0042802]	2660.38516189603	-0.659483317501667	0.749190830061677	1
Q9NWW6	Q9NWW6	NRK1_HUMAN	Nicotinamide riboside kinase 1 (NRK 1) (NmR-K 1) (EC 2.7.1.22) (Nicotinic acid riboside kinase 1) (EC 2.7.1.173) (Ribosylnicotinamide kinase 1) (RNK 1) (Ribosylnicotinic acid kinase 1)	NMRK1	NAD biosynthetic process [GO:0009435]; NAD metabolic process [GO:0019674]; phosphorylation [GO:0016310]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; ribosylnicotinamide kinase activity [GO:0050262]; ribosylnicotinate kinase activity [GO:0061769]	8604.451435544019	-0.0524647182722669	0.927589884876393	1
Q9ULX3	Q9ULX3	NOB1_HUMAN	RNA-binding protein NOB1 (EC 3.1.-.-) (Phosphorylation regulatory protein HP-10) (Protein ART-4)	NOB1	maturation of SSU-rRNA [GO:0030490]; rRNA processing [GO:0006364]; visual perception [GO:0007601]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; preribosome, small subunit precursor [GO:0030688]	metal ion binding [GO:0046872]; RNA endonuclease activity [GO:0004521]	11992.8485096718	-0.0578412090854093	0.845662866495911	1
Q9Y3T9	Q9Y3T9	NOC2L_HUMAN	Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor)	NOC2L	apoptotic process [GO:0006915]; cellular response to UV [GO:0034644]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ribosomal large subunit biogenesis [GO:0042273]; transcription initiation-coupled chromatin remodeling [GO:0045815]	chromosome [GO:0005694]; cytosol [GO:0005829]; Noc1p-Noc2p complex [GO:0030690]; Noc2p-Noc3p complex [GO:0030691]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]	11810.06472755285	-0.106332523332374	0.805997442759355	1
Q8WTT2	Q8WTT2	NOC3L_HUMAN	Nucleolar complex protein 3 homolog (NOC3 protein homolog) (Factor for adipocyte differentiation 24) (NOC3-like protein) (Nucleolar complex-associated protein 3-like protein)	NOC3L	DNA replication initiation [GO:0006270]; fat cell differentiation [GO:0045444]	mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	chromatin binding [GO:0003682]; RNA binding [GO:0003723]	5910.302883474855	0.00670437848896495	0.999999896420585	1
Q9BVI4	Q9BVI4	NOC4L_HUMAN	Nucleolar complex protein 4 homolog (NOC4 protein homolog) (NOC4-like protein) (Nucleolar complex-associated protein 4-like protein)	NOC4L	rRNA processing [GO:0006364]	Noc4p-Nop14p complex [GO:0030692]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]	3108.3799216713396	0.14920575993699	0.972686739736465	1
Q9BSC4	Q9BSC4	NOL10_HUMAN	Nucleolar protein 10	NOL10	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]	90S preribosome [GO:0030686]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]	5963.20785749888	-0.114278021008247	0.788781510006668	1
Q14978	Q14978	NOLC1_HUMAN	Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130)	NOLC1	mitotic cell cycle [GO:0000278]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; nucleolus organization [GO:0007000]; regulation of translation [GO:0006417]; rRNA processing [GO:0006364]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; GTP binding [GO:0005525]; molecular function inhibitor activity [GO:0140678]; protein heterodimerization activity [GO:0046982]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]	18732.18227235655	0.00122507541705486	0.999999711804995	1
Q15155	Q15155	NOMO1_HUMAN	BOS complex subunit NOMO1 (Nodal modulator 1) (pM5 protein)	NOMO1	multi-pass transmembrane protein insertion into ER membrane [GO:0160063]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; multi-pass translocon complex [GO:0160064]	carbohydrate binding [GO:0030246]; ribosome binding [GO:0043022]	6600.143400568781	-0.729393050820771	0.800194222807228	1
P69849;Q5JPE7	P69849	NOMO3_HUMAN	BOS complex subunit NOMO3 (Nodal modulator 3) (pM5 protein 3)	NOMO3	determination of left/right asymmetry in lateral mesoderm [GO:0003140]; multi-pass transmembrane protein insertion into ER membrane [GO:0160063]; negative regulation of nodal signaling pathway [GO:1900108]	endoplasmic reticulum membrane [GO:0005789]; multi-pass translocon complex [GO:0160064]	carbohydrate binding [GO:0030246]; ribosome binding [GO:0043022]	36898.6890709293	-0.025489830965934	0.999996335921752	1
Q15233	Q15233	NONO_HUMAN	Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit)	NONO	activation of innate immune response [GO:0002218]; circadian rhythm [GO:0007623]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; innate immune response [GO:0045087]; mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; RNA splicing [GO:0008380]	chromosome [GO:0005694]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; RNA polymerase II transcription regulator complex [GO:0090575]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]	113916.8812038195	0.0748016554211717	0.944945329666188	1
Q9NPE3	Q9NPE3	NOP10_HUMAN	H/ACA ribonucleoprotein complex subunit 3 (Nucleolar protein 10) (Nucleolar protein family A member 3) (snoRNP protein NOP10)	NOP10	positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; pseudouridine synthesis [GO:0001522]; rRNA pseudouridine synthesis [GO:0031118]; snRNA pseudouridine synthesis [GO:0031120]; telomere maintenance via telomerase [GO:0007004]	box H/ACA scaRNP complex [GO:0072589]; box H/ACA snoRNP complex [GO:0031429]; box H/ACA telomerase RNP complex [GO:0090661]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]; telomerase holoenzyme complex [GO:0005697]	box H/ACA snoRNA binding [GO:0034513]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]	22742.300922389848	-0.0643770466737852	0.764908180664426	1
P78316	P78316	NOP14_HUMAN	Nucleolar protein 14 (Nucleolar complex protein 14)	NOP14	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; maturation of SSU-rRNA [GO:0030490]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	90S preribosome [GO:0030686]; membrane [GO:0016020]; Noc4p-Nop14p complex [GO:0030692]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	enzyme binding [GO:0019899]; RNA binding [GO:0003723]; snoRNA binding [GO:0030515]	4905.971129892279	-0.111943124918421	0.982764229950314	1
P46087	P46087	NOP2_HUMAN	Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120)	NOP2	maturation of LSU-rRNA [GO:0000470]; positive regulation of cell population proliferation [GO:0008284]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; rRNA base methylation [GO:0070475]; tRNA methylation [GO:0030488]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	RNA binding [GO:0003723]; rRNA (cytosine-C5-)-methyltransferase activity [GO:0009383]; tRNA (cytidine-5-)-methyltransferase activity [GO:0016428]	27002.66253766375	0.0852977407609095	0.777947441402755	1
Q9NZM5	Q9NZM5	NOP53_HUMAN	Ribosome biogenesis protein NOP53 (Glioma tumor suppressor candidate region gene 2 protein) (Protein interacting with carboxyl terminus 1) (PICT-1) (p60)	NOP53	cellular response to hypoxia [GO:0071456]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901837]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein K63-linked deubiquitination [GO:1903006]; protein localization to nucleolus [GO:1902570]; protein localization to nucleoplasm [GO:1990173]; protein stabilization [GO:0050821]; regulation of aerobic respiration [GO:1903715]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of protein phosphorylation [GO:0001932]; regulation of RIG-I signaling pathway [GO:0039535]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; rRNA processing [GO:0006364]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	5S rRNA binding [GO:0008097]; identical protein binding [GO:0042802]; p53 binding [GO:0002039]; RNA binding [GO:0003723]	10656.801218066801	0.0635703368223588	0.808719421605063	1
Q9Y2X3	Q9Y2X3	NOP58_HUMAN	Nucleolar protein 58 (Nucleolar protein 5)	NOP58	ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; snoRNA localization [GO:0048254]	box C/D RNP complex [GO:0031428]; Cajal body [GO:0015030]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; pre-snoRNP complex [GO:0070761]; small-subunit processome [GO:0032040]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]	ATPase binding [GO:0051117]; RNA binding [GO:0003723]; snoRNA binding [GO:0030515]; TFIID-class transcription factor complex binding [GO:0001094]	28053.167941225	-0.0560041196066321	0.999695517638361	1
Q04721	Q04721	NOTC2_HUMAN	Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]	NOTCH2	animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; atrial septum morphogenesis [GO:0060413]; atrioventricular node development [GO:0003162]; axon guidance [GO:0007411]; BMP signaling pathway [GO:0030509]; bone remodeling [GO:0046849]; cell fate determination [GO:0001709]; cellular response to tumor cell [GO:0071228]; cholangiocyte proliferation [GO:1990705]; ciliary body morphogenesis [GO:0061073]; defense response to bacterium [GO:0042742]; embryonic limb morphogenesis [GO:0030326]; glomerular capillary formation [GO:0072104]; heart looping [GO:0001947]; hemopoiesis [GO:0030097]; hepatocyte proliferation [GO:0072574]; humoral immune response [GO:0006959]; in utero embryonic development [GO:0001701]; inflammatory response to antigenic stimulus [GO:0002437]; intracellular signal transduction [GO:0035556]; intrahepatic bile duct development [GO:0035622]; left/right axis specification [GO:0070986]; marginal zone B cell differentiation [GO:0002315]; morphogenesis of an epithelial sheet [GO:0002011]; multicellular organism growth [GO:0035264]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; Notch signaling pathway [GO:0007219]; placenta blood vessel development [GO:0060674]; podocyte development [GO:0072015]; positive regulation of apoptotic process [GO:0043065]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of smooth muscle cell differentiation [GO:0051152]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal tubule development [GO:0072014]; pulmonary valve morphogenesis [GO:0003184]; regulation of osteoclast development [GO:2001204]; wound healing [GO:0042060]	cell surface [GO:0009986]; cilium [GO:0005929]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]	calcium ion binding [GO:0005509]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; enzyme binding [GO:0019899]; NF-kappaB binding [GO:0051059]; Notch binding [GO:0005112]; signaling receptor activity [GO:0038023]	23120.6367153701	0.0716277693149664	0.942841822747717	1
P04150	P04150	GCR_HUMAN	Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1)	NR3C1	adrenal gland development [GO:0030325]; apoptotic process [GO:0006915]; astrocyte differentiation [GO:0048708]; cell division [GO:0051301]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to steroid hormone stimulus [GO:0071383]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chromatin organization [GO:0006325]; chromosome segregation [GO:0007059]; gene expression [GO:0010467]; glucocorticoid metabolic process [GO:0008211]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; mammary gland duct morphogenesis [GO:0060603]; maternal behavior [GO:0042711]; microglia differentiation [GO:0014004]; motor behavior [GO:0061744]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuroinflammatory response [GO:0150076]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of glucocorticoid biosynthetic process [GO:0031946]; regulation of gluconeogenesis [GO:0006111]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; synaptic transmission, glutamatergic [GO:0035249]	centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; synapse [GO:0045202]	core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; estrogen response element binding [GO:0034056]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; nuclear glucocorticoid receptor activity [GO:0004883]; nuclear receptor activity [GO:0004879]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; steroid binding [GO:0005496]; steroid hormone binding [GO:1990239]; TBP-class protein binding [GO:0017025]; zinc ion binding [GO:0008270]	21283.34643600155	0.0300144913066972	0.999865062486216	1
Q96F24	Q96F24	NRBF2_HUMAN	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR)	NRBF2	autophagy [GO:0006914]; response to endoplasmic reticulum stress [GO:0034976]	autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; nucleoplasm [GO:0005654]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]		10473.006918629799	-0.0920297323552199	0.684856211462871	1
Q9UHY1	Q9UHY1	NRBP_HUMAN	Nuclear receptor-binding protein	NRBP1	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular signal transduction [GO:0035556]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	ATP binding [GO:0005524]; protein homodimerization activity [GO:0042803]; protein serine/threonine kinase activity [GO:0004674]	20808.05283081625	0.00774968118140437	0.999999291851781	1
Q9NSY0	Q9NSY0	NRBP2_HUMAN	Nuclear receptor-binding protein 2 (Transformation-related gene 16 protein) (TRG-16)	NRBP2	intracellular signal transduction [GO:0035556]; negative regulation of macroautophagy [GO:0016242]; negative regulation of neuron apoptotic process [GO:0043524]; neuron differentiation [GO:0030182]	cytoplasm [GO:0005737]; endomembrane system [GO:0012505]	ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]	8044.8826435467945	-0.0903809671475977	0.907084641481959	1
O43847	O43847	NRDC_HUMAN	Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C) (Nardilysin convertase)	NRDC	amyloid-beta metabolic process [GO:0050435]; hormone catabolic process [GO:0042447]; negative regulation of cold-induced thermogenesis [GO:0120163]; peptide catabolic process [GO:0043171]; positive regulation of axonogenesis [GO:0050772]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of myelination [GO:0031643]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of endopeptidase activity [GO:0052548]	cell surface [GO:0009986]; cytosol [GO:0005829]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]	epidermal growth factor binding [GO:0048408]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	10546.49829910019	-0.108241924269143	0.709103086249377	1
Q08J23	Q08J23	NSUN2_HUMAN	RNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-, EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4)	NSUN2	cell division [GO:0051301]; hair follicle maturation [GO:0048820]; in utero embryonic development [GO:0001701]; meiotic cell cycle checkpoint signaling [GO:0033313]; mRNA methylation [GO:0080009]; regulation of mRNA export from nucleus [GO:0010793]; regulation of stem cell differentiation [GO:2000736]; spermatid development [GO:0007286]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]; tRNA stabilization [GO:0036416]	chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]	mRNA (cytidine-5-)-methyltransferase activity [GO:0062152]; RNA binding [GO:0003723]; tRNA (cytidine-5-)-methyltransferase activity [GO:0016428]; tRNA binding [GO:0000049]	9732.085453099495	0.0865944091113836	0.981565886804203	1
Q8TCD5	Q8TCD5	NT5C_HUMAN	5'(3')-deoxyribonucleotidase, cytosolic type (EC 3.1.3.-) (Cytosolic 5',3'-pyrimidine nucleotidase) (Deoxy-5'-nucleotidase 1) (dNT-1)	NT5C	allantoin metabolic process [GO:0000255]; amide catabolic process [GO:0043605]; dCMP catabolic process [GO:0006249]; dephosphorylation [GO:0016311]; dGMP catabolic process [GO:0046055]; dTMP catabolic process [GO:0046074]; dUMP catabolic process [GO:0046079]; IMP catabolic process [GO:0006204]; pyrimidine deoxyribonucleotide catabolic process [GO:0009223]; UMP catabolic process [GO:0046050]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	5'-nucleotidase activity [GO:0008253]; identical protein binding [GO:0042802]; IMP 5'-nucleotidase activity [GO:0050483]; metal ion binding [GO:0046872]; nucleotidase activity [GO:0008252]; pyrimidine nucleotide binding [GO:0019103]	9727.724126465595	0.0190002789444471	0.999999542027339	1
P49902	P49902	5NTC_HUMAN	Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (EC 3.1.3.99) (Cytosolic 5'-nucleotidase II) (cN-II) (Cytosolic IMP/GMP-specific 5'-nucleotidase) (Cytosolic nucleoside phosphotransferase 5'N) (EC 2.7.1.77) (High Km 5'-nucleotidase)	NT5C2	adenosine metabolic process [GO:0046085]; allantoin metabolic process [GO:0000255]; dGMP metabolic process [GO:0046054]; GMP metabolic process [GO:0046037]; IMP catabolic process [GO:0006204]; IMP metabolic process [GO:0046040]; negative regulation of defense response to virus by host [GO:0050689]; protein K48-linked ubiquitination [GO:0070936]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	5'-nucleotidase activity [GO:0008253]; ATP binding [GO:0005524]; GMP 5'-nucleotidase activity [GO:0050484]; identical protein binding [GO:0042802]; IMP 5'-nucleotidase activity [GO:0050483]; metal ion binding [GO:0046872]; nucleoside phosphotransferase activity [GO:0050146]; ubiquitin protein ligase activity [GO:0061630]; XMP 5'-nucleosidase activity [GO:0106411]	15891.89350980575	-0.0523414769239323	0.999995342927201	1
Q5TFE4	Q5TFE4	NT5D1_HUMAN	5'-nucleotidase domain-containing protein 1 (EC 3.1.3.-)	NT5DC1			5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872]	11894.976166373199	0.197622471639247	0.785936360058784	1
P80303	P80303	NUCB2_HUMAN	Nucleobindin-2 (DNA-binding protein NEFA) (Epididymis secretory protein Li 109) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1]	NUCB2	sequestering of metal ion [GO:0051238]; small GTPase-mediated signal transduction [GO:0007264]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; DNA binding [GO:0003677]; G-protein alpha-subunit binding [GO:0001965]; guanyl-nucleotide exchange factor activity [GO:0005085]; ion binding [GO:0043167]	112754.4620352115	0.0594198015453583	0.999882051824234	1
Q96RS6	Q96RS6	NUDC1_HUMAN	NudC domain-containing protein 1 (Chronic myelogenous leukemia tumor antigen 66) (Tumor antigen CML66)	NUDCD1	immune system process [GO:0002376]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]		10533.282702865901	-0.00779261426050778	0.999999916740317	1
A8MXV4	A8MXV4	NUD19_HUMAN	Acyl-coenzyme A diphosphatase NUDT19 (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 19) (Nudix motif 19)	NUDT19	butyryl-CoA catabolic process [GO:0044580]; coenzyme A catabolic process [GO:0015938]; fatty acid catabolic process [GO:0009062]; malonyl-CoA catabolic process [GO:2001294]; medium-chain fatty-acyl-CoA catabolic process [GO:0036114]; propionyl-CoA metabolic process [GO:1902858]; succinyl-CoA catabolic process [GO:1901289]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]	coenzyme A diphosphatase activity [GO:0010945]; magnesium ion binding [GO:0000287]	5417.97723977647	0.0163907260619891	0.999382867660528	1
Q8WUM0	Q8WUM0	NU133_HUMAN	Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133)	NUP133	mRNA export from nucleus [GO:0006406]; nephron development [GO:0072006]; neural tube development [GO:0021915]; neurogenesis [GO:0022008]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; paraxial mesoderm development [GO:0048339]; poly(A)+ mRNA export from nucleus [GO:0016973]; protein import into nucleus [GO:0006606]; somite development [GO:0061053]; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000972]	cytosol [GO:0005829]; kinetochore [GO:0000776]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]	structural constituent of nuclear pore [GO:0017056]	7720.220754828255	-0.184507898418891	0.663704279282189	1
P49790	P49790	NU153_HUMAN	Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153)	NUP153	amyloid fibril formation [GO:1990000]; mRNA transport [GO:0051028]; negative regulation of RNA export from nucleus [GO:0046832]; nuclear pore complex assembly [GO:0051292]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405]; symbiont entry into host cell [GO:0046718]; viral penetration into host nucleus [GO:0075732]	cytosol [GO:0005829]; host cell [GO:0043657]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inclusion body [GO:0042405]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore nuclear basket [GO:0044615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	DNA binding [GO:0003677]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; molecular condensate scaffold activity [GO:0140693]; nuclear localization sequence binding [GO:0008139]; protein-membrane adaptor activity [GO:0043495]; structural constituent of nuclear pore [GO:0017056]	10888.55475019685	-0.0232214978842288	0.999251227878306	1
Q5SRE5	Q5SRE5	NU188_HUMAN	Nucleoporin NUP188 (hNup188)	NUP188	mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405]	cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore inner ring [GO:0044611]	structural constituent of nuclear pore [GO:0017056]	3552.0231663025797	-0.236323463065979	0.963597877697047	1
Q8NFH5	Q8NFH5	NUP35_HUMAN	Nucleoporin NUP35 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53)	NUP35	cellular response to leukemia inhibitory factor [GO:1990830]; mRNA transport [GO:0051028]; NLS-bearing protein import into nucleus [GO:0006607]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]	cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore central transport channel [GO:0044613]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; phospholipid binding [GO:0005543]; structural constituent of nuclear pore [GO:0017056]	26373.70283771	0.0837586403162195	0.836339105891067	1
Q8NFH4	Q8NFH4	NUP37_HUMAN	Nucleoporin Nup37 (p37) (Nup107-160 subcomplex subunit Nup37)	NUP37	cell division [GO:0051301]; chromosome segregation [GO:0007059]; mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]	cytosol [GO:0005829]; kinetochore [GO:0000776]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		8669.787493994696	0.0248019297762157	0.998476489583037	1
Q8NFH3	Q8NFH3	NUP43_HUMAN	Nucleoporin Nup43 (Nup107-160 subcomplex subunit Nup43) (p42)	NUP43	cell division [GO:0051301]; chromosome segregation [GO:0007059]; mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]	cytosol [GO:0005829]; kinetochore [GO:0000776]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]		18150.02384899605	0.0484933960035593	0.989956105825374	1
Q9BVL2	Q9BVL2	NUP58_HUMAN	Nucleoporin p58/p45 (58 kDa nucleoporin) (Nucleoporin-like protein 1)	NUP58	mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]; regulation of protein import into nucleus [GO:0042306]	nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]	identical protein binding [GO:0042802]; nuclear localization sequence binding [GO:0008139]; protein-containing complex binding [GO:0044877]; structural constituent of nuclear pore [GO:0017056]	15692.167289524099	0.12863599845325	0.766256011894192	1
P37198	P37198	NUP62_HUMAN	Nuclear pore glycoprotein p62 (62 kDa nucleoporin) (Nucleoporin Nup62)	NUP62	cell surface receptor signaling pathway [GO:0007166]; cellular senescence [GO:0090398]; centriole assembly [GO:0098534]; centrosome cycle [GO:0007098]; mitotic centrosome separation [GO:0007100]; mitotic metaphase chromosome alignment [GO:0007080]; mRNA transport [GO:0051028]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of programmed cell death [GO:0043069]; negative regulation of Ras protein signal transduction [GO:0046580]; nucleocytoplasmic transport [GO:0006913]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of centriole replication [GO:0046601]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of mitotic cytokinetic process [GO:1903438]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of protein localization to centrosome [GO:1904781]; protein import into nucleus [GO:0006606]; regulation of mitotic spindle organization [GO:0060236]; regulation of Ras protein signal transduction [GO:0046578]; regulation of signal transduction [GO:0009966]; RNA export from nucleus [GO:0006405]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; Flemming body [GO:0090543]; mitotic spindle [GO:0072686]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore central transport channel [GO:0044613]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; spindle pole [GO:0000922]	chromatin binding [GO:0003682]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; phospholipid binding [GO:0005543]; PTB domain binding [GO:0051425]; SH2 domain binding [GO:0042169]; signaling receptor complex adaptor activity [GO:0030159]; structural constituent of nuclear pore [GO:0017056]; ubiquitin binding [GO:0043130]	22425.7006225892	0.0584661832454366	0.940525452130162	1
Q8N1F7	Q8N1F7	NUP93_HUMAN	Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93)	NUP93	nuclear envelope organization [GO:0006998]; nuclear pore complex assembly [GO:0051292]; nucleocytoplasmic transport [GO:0006913]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of SMAD protein signal transduction [GO:0060391]; protein import into nucleus [GO:0006606]	centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]	structural constituent of nuclear pore [GO:0017056]	17867.20012202435	-0.0958813045989184	0.875734316717932	1
Q01968	Q01968	OCRL_HUMAN	Inositol polyphosphate 5-phosphatase OCRL (EC 3.1.3.36) (EC 3.1.3.56) (Inositol polyphosphate 5-phosphatase OCRL-1) (OCRL-1) (Lowe oculocerebrorenal syndrome protein) (Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase) (EC 3.1.3.86)	OCRL	cilium assembly [GO:0060271]; in utero embryonic development [GO:0001701]; inositol phosphate metabolic process [GO:0043647]; lipid metabolic process [GO:0006629]; membrane organization [GO:0061024]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; signal transduction [GO:0007165]	clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; Golgi stack [GO:0005795]; Golgi-associated vesicle [GO:0005798]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleus [GO:0005634]; phagocytic vesicle membrane [GO:0030670]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	GTPase activator activity [GO:0005096]; inositol phosphate phosphatase activity [GO:0052745]; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; inositol-polyphosphate 5-phosphatase activity [GO:0004445]; phosphatidylinositol phosphate 4-phosphatase activity [GO:0034596]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; small GTPase binding [GO:0031267]	5120.82573100857	-0.325892440846017	0.666502229905723	1
Q5SWX8	Q5SWX8	ODR4_HUMAN	Protein odr-4 homolog (hODR-4) (LAG1-interacting protein) (Transactivated by transforming growth factor beta protein 1)	ODR4	protein localization [GO:0008104]	endomembrane system [GO:0012505]; membrane [GO:0016020]		16606.74558516055	0.0794372609219318	0.999853125331062	1
O60502	O60502	OGA_HUMAN	Protein O-GlcNAcase (OGA) (EC 3.2.1.169) (Beta-N-acetylglucosaminidase) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (NCOAT)	OGA	glycoprotein catabolic process [GO:0006516]; glycoprotein metabolic process [GO:0009100]; N-acetylglucosamine metabolic process [GO:0006044]; protein deglycosylation [GO:0006517]; protein O-linked glycosylation [GO:0006493]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]	[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity [GO:0102167]; [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity [GO:0102571]; [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity [GO:0102166]; beta-N-acetylglucosaminidase activity [GO:0016231]; hyalurononglucosaminidase activity [GO:0004415]; identical protein binding [GO:0042802]	10072.588765025066	-0.176170403576175	0.754059802135578	1
Q02218	Q02218	ODO1_HUMAN	2-oxoglutarate dehydrogenase complex component E1 (E1o) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase)	OGDH	2-oxoglutarate metabolic process [GO:0006103]; cerebellar cortex development [GO:0021695]; generation of precursor metabolites and energy [GO:0006091]; glycolytic process [GO:0006096]; hippocampus development [GO:0021766]; histone succinylation [GO:0106077]; olfactory bulb mitral cell layer development [GO:0061034]; pyramidal neuron development [GO:0021860]; striatum development [GO:0021756]; succinyl-CoA metabolic process [GO:0006104]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028]; thalamus development [GO:0021794]; tricarboxylic acid cycle [GO:0006099]	mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; oxoglutarate dehydrogenase complex [GO:0045252]	metal ion binding [GO:0046872]; oxoglutarate dehydrogenase (NAD+) activity [GO:0034602]; oxoglutarate dehydrogenase (succinyl-transferring) activity [GO:0004591]; thiamine pyrophosphate binding [GO:0030976]	17977.92424305415	0.077225023341644	0.999933706497263	1
Q8N543	Q8N543	OGFD1_HUMAN	Prolyl 3-hydroxylase OGFOD1 (EC 1.14.11.-) (2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1) (Termination and polyadenylation 1 homolog) (uS12 prolyl 3-hydroxylase)	OGFOD1	cell population proliferation [GO:0008283]; peptidyl-proline hydroxylation [GO:0019511]; protein hydroxylation [GO:0018126]; regulation of translational termination [GO:0006449]; stress granule assembly [GO:0034063]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; peptidyl-proline 3-dioxygenase activity [GO:0031544]; peptidyl-proline dioxygenase activity [GO:0031543]	1772.8975062435502	0.801007364751936	0.929760604539875	1
Q5TC84	Q5TC84	OGRL1_HUMAN	Opioid growth factor receptor-like protein 1	OGFRL1		membrane [GO:0016020]	opioid growth factor receptor activity [GO:0140625]	3807.14110114173	0.00226021051595851	0.999996751470113	1
O15294	O15294	OGT1_HUMAN	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT)	OGT	apoptotic process [GO:0006915]; cellular response to glucose stimulus [GO:0071333]; chromatin organization [GO:0006325]; circadian regulation of gene expression [GO:0032922]; hemopoiesis [GO:0030097]; mitophagy [GO:0000423]; negative regulation of cell migration [GO:0030336]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of proteolysis [GO:0045862]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]; positive regulation of translation [GO:0045727]; protein O-linked glycosylation [GO:0006493]; protein processing [GO:0016485]; regulation of gluconeogenesis [GO:0006111]; regulation of glycolytic process [GO:0006110]; regulation of insulin receptor signaling pathway [GO:0046626]; regulation of necroptotic process [GO:0060544]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of Rac protein signal transduction [GO:0035020]; regulation of synapse assembly [GO:0051963]; regulation of transcription by RNA polymerase II [GO:0006357]; response to insulin [GO:0032868]; response to nutrient [GO:0007584]; signal transduction [GO:0007165]	cell projection [GO:0042995]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; histone acetyltransferase complex [GO:0000123]; mitochondrial membrane [GO:0031966]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein N-acetylglucosaminyltransferase complex [GO:0017122]; protein-containing complex [GO:0032991]	acetylglucosaminyltransferase activity [GO:0008375]; chromatin DNA binding [GO:0031490]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; protein O-acetylglucosaminyltransferase activity [GO:0097363]	6738.252778488964	-0.134958879295617	0.829400710673318	1
O14841	O14841	OPLA_HUMAN	5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (5-OPase) (Pyroglutamase)	OPLAH	glutathione metabolic process [GO:0006749]	cytosol [GO:0005829]	5-oxoprolinase (ATP-hydrolyzing) activity [GO:0017168]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]	4667.348517771965	-0.13373660976389	0.748710788698024	1
Q96CV9	Q96CV9	OPTN_HUMAN	Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)	OPTN	autophagy [GO:0006914]; cell death [GO:0008219]; cellular response to unfolded protein [GO:0034620]; defense response to Gram-negative bacterium [GO:0050829]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; Golgi to plasma membrane protein transport [GO:0043001]; innate immune response [GO:0045087]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of receptor recycling [GO:0001920]; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [GO:0061734]; positive regulation of autophagy [GO:0010508]; positive regulation of xenophagy [GO:1904417]; protein localization to Golgi apparatus [GO:0034067]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; signal transduction [GO:0007165]	autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]	identical protein binding [GO:0042802]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein-macromolecule adaptor activity [GO:0030674]	22213.624199537102	-0.023959483713928	0.999999238084867	1
Q9H1P3	Q9H1P3	OSBL2_HUMAN	Oxysterol-binding protein-related protein 2 (ORP-2) (OSBP-related protein 2)	OSBPL2	bile acid biosynthetic process [GO:0006699]; cholesterol transport [GO:0030301]; intracellular cholesterol transport [GO:0032367]; phospholipid transport [GO:0015914]; plasma membrane organization [GO:0007009]; protein homotetramerization [GO:0051289]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]	cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; phosphatidylinositol transfer activity [GO:0008526]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; sterol transporter activity [GO:0015248]	4448.208331488026	-0.0468641670976753	0.973902447730487	1
Q96SU4	Q96SU4	OSBL9_HUMAN	Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9)	OSBPL9	bile acid biosynthetic process [GO:0006699]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; membrane [GO:0016020]	sterol binding [GO:0032934]; sterol transporter activity [GO:0015248]	6966.005637104615	-0.00575098013945109	0.999999999995229	1
Q9NPF4	Q9NPF4	OSGEP_HUMAN	tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (O-sialoglycoprotein endopeptidase) (hOSGEP) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP) (tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP)	OSGEP	tRNA modification [GO:0006400]; tRNA threonylcarbamoyladenosine modification [GO:0002949]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; EKC/KEOPS complex [GO:0000408]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; N(6)-L-threonylcarbamoyladenine synthase activity [GO:0061711]	10226.470723325201	-0.00399032437531021	0.99998899386605	1
Q8N6M0	Q8N6M0	OTU6B_HUMAN	Deubiquitinase OTUD6B (EC 3.4.19.12) (DUBA-5) (OTU domain-containing protein 6B)	OTUD6B	cell population proliferation [GO:0008283]; negative regulation of translation [GO:0017148]; positive regulation of translation [GO:0045727]; proteasome assembly [GO:0043248]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]		cysteine-type deubiquitinase activity [GO:0004843]	10619.3998542788	0.0830369107956266	0.874289349542486	1
Q96BN8	Q96BN8	OTUL_HUMAN	Ubiquitin thioesterase otulin (EC 3.4.19.12) (Deubiquitinating enzyme otulin) (OTU domain-containing deubiquitinase with linear linkage specificity) (Ubiquitin thioesterase Gumby)	OTULIN	innate immune response [GO:0045087]; negative regulation of inflammatory response [GO:0050728]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; protein linear deubiquitination [GO:1990108]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; sprouting angiogenesis [GO:0002040]; Wnt signaling pathway [GO:0016055]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; LUBAC complex [GO:0071797]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type peptidase activity [GO:0008234]	10730.25866590485	0.0670277185106728	0.756871010980587	1
O95747	O95747	OXSR1_HUMAN	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein)	OXSR1	cell volume homeostasis [GO:0006884]; cellular hyperosmotic response [GO:0071474]; cellular hypotonic response [GO:0071476]; cellular response to chemokine [GO:1990869]; chemokine (C-C motif) ligand 21 signaling pathway [GO:0038116]; chemokine (C-X-C motif) ligand 12 signaling pathway [GO:0038146]; intracellular signal transduction [GO:0035556]; negative regulation of potassium ion transmembrane transport [GO:1901380]; osmosensory signaling pathway [GO:0007231]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of T cell chemotaxis [GO:0010820]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; renal sodium ion absorption [GO:0070294]; response to oxidative stress [GO:0006979]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	27607.17218036435	0.0459813157722262	0.784820475513682	1
Q32P28	Q32P28	P3H1_HUMAN	Prolyl 3-hydroxylase 1 (EC 1.14.11.7) (Growth suppressor 1) (Leucine- and proline-enriched proteoglycan 1) (Leprecan-1)	P3H1	bone development [GO:0060348]; chaperone-mediated protein folding [GO:0061077]; collagen metabolic process [GO:0032963]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of post-translational protein modification [GO:1901874]; positive regulation of neuron projection development [GO:0010976]; protein folding [GO:0006457]; protein hydroxylation [GO:0018126]; protein stabilization [GO:0050821]; regulation of protein secretion [GO:0050708]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 3-dioxygenase activity [GO:0019797]	187102.6536659855	0.0651349401429876	0.998663691453676	1
Q92791	Q92791	SC65_HUMAN	Endoplasmic reticulum protein SC65 (Leprecan-like protein 4) (Nucleolar autoantigen No55) (Prolyl 3-hydroxylase family member 4) (Synaptonemal complex protein SC65)	P3H4	bone remodeling [GO:0046849]; collagen biosynthetic process [GO:0032964]; collagen fibril organization [GO:0030199]; peptidyl-lysine hydroxylation [GO:0017185]; synaptonemal complex assembly [GO:0007130]	catalytic complex [GO:1902494]; condensed nuclear chromosome [GO:0000794]; endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; synaptonemal complex [GO:0000795]	collagen binding [GO:0005518]	71978.0181012307	0.0142541740346866	0.999993615600132	1
P13674	P13674	P4HA1_HUMAN	Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1)	P4HA1	collagen fibril organization [GO:0030199]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; procollagen-proline 4-dioxygenase complex [GO:0016222]	identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 4-dioxygenase activity [GO:0004656]	225863.1962353845	0.0080071597425105	0.999999999997893	1
Q9NXG6	Q9NXG6	P4HTM_HUMAN	Transmembrane prolyl 4-hydroxylase (P4H-TM) (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 4) (HIF-PH4) (HIF-prolyl hydroxylase 4) (HPH-4)	P4HTM	regulation of erythrocyte differentiation [GO:0045646]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; calcium ion binding [GO:0005509]; hypoxia-inducible factor-proline dioxygenase activity [GO:0160082]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 4-dioxygenase activity [GO:0004656]	15417.1690613615	0.131660516931238	0.774183067001056	1
Q9UQ80	Q9UQ80	PA2G4_HUMAN	Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1)	PA2G4	negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell differentiation [GO:0045597]; regulation of translation [GO:0006417]; rRNA processing [GO:0006364]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625]	68386.86288993014	-0.00300069933733227	1	1
Q9BRP4	Q9BRP4	PAAF1_HUMAN	Proteasomal ATPase-associated factor 1 (Protein G-16) (WD repeat-containing protein 71)	PAAF1	transcription initiation at RNA polymerase II promoter [GO:0006367]	proteasome complex [GO:0000502]; transcription factor TFIID complex [GO:0005669]		18849.7875170903	-0.035110415851998	0.689214071331959	1
Q13310	Q13310	PABP4_HUMAN	Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP)	PABPC4	blood coagulation [GO:0007596]; myeloid cell development [GO:0061515]; regulation of mRNA stability [GO:0043488]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; translation [GO:0006412]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]	26277.439792110497	0.00935746765618601	0.999996191899738	1
Q86U42	Q86U42	PABP2_HUMAN	Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1)	PABPN1	cellular response to lipopolysaccharide [GO:0071222]; MAPK cascade [GO:0000165]; mRNA processing [GO:0006397]; muscle contraction [GO:0006936]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of polynucleotide adenylyltransferase activity [GO:1904247]; RNA processing [GO:0006396]	cytoplasm [GO:0005737]; nuclear inclusion body [GO:0042405]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	poly(A) binding [GO:0008143]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]	49958.8922852924	0.111786841914886	0.695615240094545	1
P43034	P43034	LIS1_HUMAN	Platelet-activating factor acetylhydrolase IB subunit beta (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha)	PAFAH1B1	acrosome assembly [GO:0001675]; actin cytoskeleton organization [GO:0030036]; adult locomotory behavior [GO:0008344]; ameboidal-type cell migration [GO:0001667]; auditory receptor cell development [GO:0060117]; brain morphogenesis [GO:0048854]; cerebral cortex development [GO:0021987]; cerebral cortex neuron differentiation [GO:0021895]; chemical synaptic transmission [GO:0007268]; cochlea development [GO:0090102]; corpus callosum morphogenesis [GO:0021540]; cortical microtubule organization [GO:0043622]; establishment of centrosome localization [GO:0051660]; establishment of mitotic spindle orientation [GO:0000132]; establishment of planar polarity of embryonic epithelium [GO:0042249]; germ cell development [GO:0007281]; hippocampus development [GO:0021766]; interneuron migration [GO:1904936]; JNK cascade [GO:0007254]; layer formation in cerebral cortex [GO:0021819]; learning or memory [GO:0007611]; lipid catabolic process [GO:0016042]; maintenance of centrosome location [GO:0051661]; microtubule cytoskeleton organization [GO:0000226]; microtubule cytoskeleton organization involved in establishment of planar polarity [GO:0090176]; microtubule organizing center organization [GO:0031023]; microtubule sliding [GO:0051012]; microtubule-based process [GO:0007017]; modulation of chemical synaptic transmission [GO:0050804]; myeloid leukocyte migration [GO:0097529]; negative regulation of JNK cascade [GO:0046329]; negative regulation of neuron projection development [GO:0010977]; neuroblast proliferation [GO:0007405]; neuromuscular process controlling balance [GO:0050885]; neuron migration [GO:0001764]; nuclear membrane disassembly [GO:0051081]; nuclear migration [GO:0007097]; osteoclast development [GO:0036035]; platelet activating factor metabolic process [GO:0046469]; positive regulation of axon extension [GO:0045773]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of embryonic development [GO:0040019]; positive regulation of mitotic cell cycle [GO:0045931]; protein secretion [GO:0009306]; radial glia-guided pyramidal neuron migration [GO:0140650]; reelin-mediated signaling pathway [GO:0038026]; regulation of microtubule cytoskeleton organization [GO:0070507]; retrograde axonal transport [GO:0008090]; stem cell division [GO:0017145]; transmission of nerve impulse [GO:0019226]; vesicle transport along microtubule [GO:0047496]	1-alkyl-2-acetylglycerophosphocholine esterase complex [GO:0008247]; astral microtubule [GO:0000235]; axon cytoplasm [GO:1904115]; cell cortex [GO:0005938]; cell leading edge [GO:0031252]; central region of growth cone [GO:0090724]; centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; microtubule associated complex [GO:0005875]; motile cilium [GO:0031514]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; Schaffer collateral - CA1 synapse [GO:0098685]; stereocilium [GO:0032420]	dynactin binding [GO:0034452]; dynein complex binding [GO:0070840]; dynein intermediate chain binding [GO:0045505]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; phospholipase binding [GO:0043274]; phosphoprotein binding [GO:0051219]; protein heterodimerization activity [GO:0046982]	53672.254120247846	0.0397736464957054	0.992796853948711	1
P68402	P68402	PA1B2_HUMAN	Platelet-activating factor acetylhydrolase IB subunit alpha2 (EC 3.1.1.47) (PAF acetylhydrolase 30 kDa subunit) (PAF-AH 30 kDa subunit) (PAF-AH subunit beta) (PAFAH subunit beta)	PAFAH1B2	lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; positive regulation of macroautophagy [GO:0016239]; spermatogenesis [GO:0007283]	1-alkyl-2-acetylglycerophosphocholine esterase complex [GO:0008247]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; fibrillar center [GO:0001650]; ficolin-1-rich granule lumen [GO:1904813]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]	1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; platelet-activating factor acetyltransferase activity [GO:0047179]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]	75203.30161672071	-0.0220097801221358	0.999616959317332	1
Q15102	Q15102	PA1B3_HUMAN	Platelet-activating factor acetylhydrolase IB subunit alpha1 (EC 3.1.1.47) (PAF acetylhydrolase 29 kDa subunit) (PAF-AH 29 kDa subunit) (PAF-AH subunit gamma) (PAFAH subunit gamma)	PAFAH1B3	lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; nervous system development [GO:0007399]; spermatogenesis [GO:0007283]	1-alkyl-2-acetylglycerophosphocholine esterase complex [GO:0008247]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]	1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; identical protein binding [GO:0042802]; platelet-activating factor acetyltransferase activity [GO:0047179]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]	17019.56174339245	-0.15107244007881	0.672598509400862	1
Q13153	Q13153	PAK1_HUMAN	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK)	PAK1	actin cytoskeleton organization [GO:0030036]; apoptotic process [GO:0006915]; branching morphogenesis of an epithelial tube [GO:0048754]; cell migration [GO:0016477]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; ephrin receptor signaling pathway [GO:0048013]; exocytosis [GO:0006887]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; intracellular signal transduction [GO:0035556]; localization [GO:0051179]; negative regulation of cell proliferation involved in contact inhibition [GO:0060244]; neuron projection morphogenesis [GO:0048812]; phosphorylation [GO:0016310]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of microtubule nucleation [GO:0090063]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; protein autophosphorylation [GO:0046777]; protein localization to cytoplasmic stress granule [GO:1903608]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of axonogenesis [GO:0050770]; regulation of MAPK cascade [GO:0043408]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; wound healing [GO:0042060]	actin filament [GO:0005884]; axon [GO:0030424]; cell-cell junction [GO:0005911]; centrosome [GO:0005813]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; focal adhesion [GO:0005925]; intercalated disc [GO:0014704]; lamellipodium [GO:0030027]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; Z disc [GO:0030018]	ATP binding [GO:0005524]; collagen binding [GO:0005518]; gamma-tubulin binding [GO:0043015]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	10072.669453077175	0.0204748558802074	0.999999631301083	1
Q9Y2D5	Q9Y2D5	PLAK2_HUMAN	PALM2-AKAP2 fusion protein (A-kinase anchor protein 2) (AKAP-2) (AKAP-KL) (Paralemmin A kinase anchor protein) (Paralemmin-2) (Protein kinase A-anchoring protein 2) (PRKA2)	PALM2AKAP2	regulation of cell shape [GO:0008360]	apical plasma membrane [GO:0016324]; side of membrane [GO:0098552]		22829.957832478947	-0.0306346406933813	0.99995595413307	1
Q8N3R9	Q8N3R9	PALS1_HUMAN	Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1)	PALS1	central nervous system neuron development [GO:0021954]; cerebral cortex development [GO:0021987]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; establishment or maintenance of polarity of embryonic epithelium [GO:0016332]; gene expression [GO:0010467]; generation of neurons [GO:0048699]; morphogenesis of an epithelial sheet [GO:0002011]; myelin assembly [GO:0032288]; peripheral nervous system myelin maintenance [GO:0032287]; protein localization to myelin sheath abaxonal region [GO:0035750]; protein localization to plasma membrane [GO:0072659]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]	adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; axon [GO:0030424]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lateral loop [GO:0043219]; myelin sheath adaxonal region [GO:0035749]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; Schmidt-Lanterman incisure [GO:0043220]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]	3502.9741649573452	-0.00878714554598741	0.999678394719919	1
Q9NZW5	Q9NZW5	PALS2_HUMAN	Protein PALS2 (MAGUK p55 subfamily member 6) (Membrane protein, palmitoylated 6) (Veli-associated MAGUK 1) (VAM-1)	PALS2	protein-containing complex assembly [GO:0065003]	cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]		8981.86689716394	0.119282809371111	0.768262104741656	1
Q9NVE7	Q9NVE7	PANK4_HUMAN	4'-phosphopantetheine phosphatase (EC 3.1.3.-) (Inactive pantothenic acid kinase 4) (hPanK4)	PANK4	coenzyme A biosynthetic process [GO:0015937]; pantothenate metabolic process [GO:0015939]	cytosol [GO:0005829]; nucleus [GO:0005634]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]	5848.075483796156	-0.0346508278231165	0.999806555111037	1
P51003	P51003	PAPOA_HUMAN	Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha)	PAPOLA	co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; cytoplasmic polyadenylation [GO:0180011]; mRNA 3'-end processing [GO:0031124]; mRNA polyadenylation [GO:0006378]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723]	4066.2800630443603	0.074590023195423	0.830002095520228	1
Q8TEW0	Q8TEW0	PARD3_HUMAN	Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha)	PARD3	asymmetric cell division [GO:0008356]; axonogenesis [GO:0007409]; bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; establishment of cell polarity [GO:0030010]; establishment of centrosome localization [GO:0051660]; establishment of epithelial cell polarity [GO:0090162]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; microtubule cytoskeleton organization [GO:0000226]; myelination in peripheral nervous system [GO:0022011]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; positive regulation of myelination [GO:0031643]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; protein localization [GO:0008104]; protein targeting to membrane [GO:0006612]; protein-containing complex assembly [GO:0065003]	adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; internode region of axon [GO:0033269]; PAR polarity complex [GO:0120157]; plasma membrane [GO:0005886]; tight junction [GO:0070160]	phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	6190.88732685082	0.0150471400527217	0.999988566404812	1
O95453	O95453	PARN_HUMAN	Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease)	PARN	box H/ACA RNA 3'-end processing [GO:0000495]; female gamete generation [GO:0007292]; miRNA catabolic process [GO:0010587]; ncRNA deadenylation [GO:0110008]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of telomerase RNA localization to Cajal body [GO:1904872]; RNA modification [GO:0009451]; telomerase RNA stabilization [GO:0090669]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; postsynapse [GO:0098794]	cation binding [GO:0043169]; metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; nuclease activity [GO:0004518]; poly(A)-specific ribonuclease activity [GO:0004535]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]	7277.08447370434	0.152132682569033	0.860960061438198	1
Q15365	Q15365	PCBP1_HUMAN	Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3)	PCBP1	positive regulation of transcription by RNA polymerase II [GO:0045944]; viral RNA genome replication [GO:0039694]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904]	cadherin binding [GO:0045296]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; sequence-specific single stranded DNA binding [GO:0098847]; single-stranded DNA binding [GO:0003697]	95666.70612485724	-0.0812104295135745	0.99014584779142	1
Q15366	Q15366	PCBP2_HUMAN	Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2)	PCBP2	defense response to virus [GO:0051607]; innate immune response [GO:0045087]; IRES-dependent viral translational initiation [GO:0075522]; mRNA metabolic process [GO:0016071]; negative regulation of cGAS/STING signaling pathway [GO:0160049]; negative regulation of defense response to virus [GO:0050687]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of gene expression [GO:0010468]; regulation of RNA metabolic process [GO:0051252]; viral RNA genome replication [GO:0039694]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904]	enzyme binding [GO:0019899]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase binding [GO:0031625]	121715.518725513	-0.0598503760587595	0.96586396492131	1
P05165	P05165	PCCA_HUMAN	Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCase subunit alpha) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha)	PCCA	branched-chain amino acid metabolic process [GO:0009081]; fatty acid metabolic process [GO:0006631]; short-chain fatty acid catabolic process [GO:0019626]	catalytic complex [GO:1902494]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; biotin binding [GO:0009374]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; methylcrotonoyl-CoA carboxylase activity [GO:0004485]; propionyl-CoA carboxylase activity [GO:0004658]; urea carboxylase activity [GO:0004847]	944.2347319344026	-0.161755947520874	0.695124556844142	1
P05166	P05166	PCCB_HUMAN	Propionyl-CoA carboxylase beta chain, mitochondrial (PCCase subunit beta) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit beta)	PCCB	branched-chain amino acid metabolic process [GO:0009081]; fatty acid metabolic process [GO:0006631]; short-chain fatty acid catabolic process [GO:0019626]	catalytic complex [GO:1902494]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	ATP binding [GO:0005524]; propionyl-CoA carboxylase activity [GO:0004658]	3166.1136010968703	-0.163005515850109	0.77754024135874	1
Q15154	Q15154	PCM1_HUMAN	Pericentriolar material 1 protein (PCM-1) (hPCM-1)	PCM1	centrosome cycle [GO:0007098]; cilium assembly [GO:0060271]; cytoplasmic microtubule organization [GO:0031122]; interkinetic nuclear migration [GO:0022027]; intraciliary transport involved in cilium assembly [GO:0035735]; microtubule anchoring [GO:0034453]; microtubule anchoring at centrosome [GO:0034454]; negative regulation of neurogenesis [GO:0050768]; neuron migration [GO:0001764]; neuronal stem cell population maintenance [GO:0097150]; non-motile cilium assembly [GO:1905515]; positive regulation of intracellular protein transport [GO:0090316]; protein localization to centrosome [GO:0071539]; protein-containing complex localization to centriolar satellite [GO:0140706]; regulation of protein complex stability [GO:0061635]; social behavior [GO:0035176]	apical part of cell [GO:0045177]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; pericentriolar material [GO:0000242]; protein-containing complex [GO:0032991]	identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]	4081.30803885163	-0.117866814965189	0.998458749545459	1
Q9UHG3	Q9UHG3	PCYOX_HUMAN	Prenylcysteine oxidase 1 (EC 1.8.3.5) (Prenylcysteine lyase)	PCYOX1	prenylated protein catabolic process [GO:0030327]; prenylcysteine catabolic process [GO:0030328]	extracellular exosome [GO:0070062]; lysosome [GO:0005764]; very-low-density lipoprotein particle [GO:0034361]	FAD binding [GO:0071949]; farnesylcysteine lyase activity [GO:0102149]; prenylcysteine oxidase activity [GO:0001735]	69719.45164868195	0.00366719578729642	0.999999999999992	1
Q8WUM4	Q8WUM4	PDC6I_HUMAN	Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95)	PDCD6IP	actomyosin contractile ring assembly [GO:0000915]; apoptotic process [GO:0006915]; bicellular tight junction assembly [GO:0070830]; extracellular exosome biogenesis [GO:0097734]; macroautophagy [GO:0016236]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; midbody abscission [GO:0061952]; mitotic cytokinesis [GO:0000281]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; protein homooligomerization [GO:0051260]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of extracellular exosome assembly [GO:1903551]; regulation of membrane permeability [GO:0090559]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; viral budding [GO:0046755]; viral budding via host ESCRT complex [GO:0039702]	actomyosin [GO:0042641]; bicellular tight junction [GO:0005923]; centrosome [GO:0005813]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; Flemming body [GO:0090543]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; melanosome [GO:0042470]; membrane [GO:0016020]	calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803]; proteinase activated receptor binding [GO:0031871]	63209.3363040676	-0.0719094453554993	0.747651996141309	1
Q13371	Q13371	PHLP_HUMAN	Phosducin-like protein (PHLP)	PDCL	cell projection organization [GO:0030030]; heterotrimeric G-protein complex assembly [GO:1902605]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; signal transduction [GO:0007165]; visual perception [GO:0007601]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]		18158.751895772948	0.00749805860293764	0.995952116321294	1
P16234	P16234	PGFRA_HUMAN	Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)	PDGFRA	adrenal gland development [GO:0030325]; cardiac myofibril assembly [GO:0055003]; cell activation [GO:0001775]; cell chemotaxis [GO:0060326]; cellular response to amino acid stimulus [GO:0071230]; cellular response to reactive oxygen species [GO:0034614]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic skeletal system morphogenesis [GO:0048704]; estrogen metabolic process [GO:0008210]; extracellular matrix organization [GO:0030198]; face morphogenesis [GO:0060325]; hematopoietic progenitor cell differentiation [GO:0002244]; in utero embryonic development [GO:0001701]; Leydig cell differentiation [GO:0033327]; lung development [GO:0030324]; luteinization [GO:0001553]; male genitalia development [GO:0030539]; metanephric glomerular capillary formation [GO:0072277]; negative regulation of platelet activation [GO:0010544]; odontogenesis of dentin-containing tooth [GO:0042475]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet aggregation [GO:0070527]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; platelet-derived growth factor receptor-alpha signaling pathway [GO:0035790]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [GO:0038091]; positive regulation of chemotaxis [GO:0050921]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase C activity [GO:0010863]; protein autophosphorylation [GO:0046777]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of mesenchymal stem cell differentiation [GO:2000739]; retina vasculature development in camera-type eye [GO:0061298]; roof of mouth development [GO:0060021]; signal transduction involved in regulation of gene expression [GO:0023019]; white fat cell differentiation [GO:0050872]; wound healing [GO:0042060]	cell junction [GO:0030054]; cilium [GO:0005929]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microvillus [GO:0005902]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]	ATP binding [GO:0005524]; platelet-derived growth factor alpha-receptor activity [GO:0005018]; platelet-derived growth factor binding [GO:0048407]; platelet-derived growth factor receptor binding [GO:0005161]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein-containing complex binding [GO:0044877]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; vascular endothelial growth factor binding [GO:0038085]; vascular endothelial growth factor receptor activity [GO:0005021]	7894.19405630163	-0.169961334734238	0.935448711536605	1
P08559	P08559	ODPA_HUMAN	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)	PDHA1	acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; glucose metabolic process [GO:0006006]; tricarboxylic acid cycle [GO:0006099]	mitochondrial matrix [GO:0005759]; mitochondrial pyruvate dehydrogenase complex [GO:0005967]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; pyruvate dehydrogenase complex [GO:0045254]	pyruvate dehydrogenase (acetyl-transferring) activity [GO:0004739]; pyruvate dehydrogenase (NAD+) activity [GO:0034604]	42098.63456117765	0.0718587352604282	0.902824781218103	1
Q53GG5	Q53GG5	PDLI3_HUMAN	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha-actinin-2-associated LIM protein)	PDLIM3	actin cytoskeleton organization [GO:0030036]; heart development [GO:0007507]; muscle structure development [GO:0061061]	adherens junction [GO:0005912]; cytosol [GO:0005829]; filamentous actin [GO:0031941]; stress fiber [GO:0001725]; Z disc [GO:0030018]	actin binding [GO:0003779]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]	13860.5338806016	-0.128027085109865	0.758000378627387	1
P50479	P50479	PDLI4_HUMAN	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein)	PDLIM4	actin cytoskeleton organization [GO:0030036]; excitatory chemical synaptic transmission [GO:0098976]; heart development [GO:0007507]; muscle structure development [GO:0061061]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendritic spine [GO:0043197]; early endosome lumen [GO:0031905]; early endosome membrane [GO:0031901]; filamentous actin [GO:0031941]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic membrane [GO:0045211]; recycling endosome lumen [GO:0034777]; recycling endosome membrane [GO:0055038]; stress fiber [GO:0001725]; Z disc [GO:0030018]	actin binding [GO:0003779]; alpha-actinin binding [GO:0051393]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]	166476.8358990125	-0.0545203733048986	0.78900053636131	1
Q96HC4	Q96HC4	PDLI5_HUMAN	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein)	PDLIM5	actin cytoskeleton organization [GO:0030036]; cell growth involved in cardiac muscle cell development [GO:0061049]; heart development [GO:0007507]; muscle structure development [GO:0061061]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of synapse assembly [GO:0051963]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cell projection [GO:0042995]; cytosol [GO:0005829]; filamentous actin [GO:0031941]; membrane [GO:0016020]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; stress fiber [GO:0001725]; Z disc [GO:0030018]	actin binding [GO:0003779]; actinin binding [GO:0042805]; cadherin binding involved in cell-cell adhesion [GO:0098641]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; protein kinase C binding [GO:0005080]	151704.239831403	0.0353021369614714	0.999278567334563	1
Q9P0J1	Q9P0J1	PDP1_HUMAN	[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP 1) (EC 3.1.3.43) (Protein phosphatase 2C) (Pyruvate dehydrogenase phosphatase catalytic subunit 1) (PDPC 1)	PDP1	peptidyl-threonine dephosphorylation [GO:0035970]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; pyruvate dehydrogenase (lipoamide) phosphatase complex [GO:0045253]	[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity [GO:0004741]; [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity [GO:0019909]; metal ion binding [GO:0046872]; protein serine/threonine phosphatase activity [GO:0004722]	3908.762306775425	0.192659470724934	0.869862884463655	1
Q29RF7	Q29RF7	PDS5A_HUMAN	Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112)	PDS5A	cell division [GO:0051301]; DNA repair [GO:0006281]; mitotic sister chromatid cohesion [GO:0007064]; negative regulation of DNA replication [GO:0008156]	chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]		2491.57076152878	-0.238888810913574	0.775859966753027	1
O00764	O00764	PDXK_HUMAN	Pyridoxal kinase (EC 2.7.1.35) (Pyridoxine kinase)	PDXK	phosphorylation [GO:0016310]; pyridoxal 5'-phosphate salvage [GO:0009443]; pyridoxal metabolic process [GO:0042817]; pyridoxamine metabolic process [GO:0042818]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; specific granule lumen [GO:0035580]	ATP binding [GO:0005524]; lithium ion binding [GO:0031403]; magnesium ion binding [GO:0000287]; potassium ion binding [GO:0030955]; protein homodimerization activity [GO:0042803]; pyridoxal kinase activity [GO:0008478]; pyridoxal phosphate binding [GO:0030170]; sodium ion binding [GO:0031402]; zinc ion binding [GO:0008270]	43545.0934699918	0.0142360879075526	0.999999999918457	1
O00541	O00541	PESC_HUMAN	Pescadillo homolog	PES1	cell population proliferation [GO:0008283]; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; regulation of cell cycle [GO:0051726]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]	chromosome [GO:0005694]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; PeBoW complex [GO:0070545]; preribosome, large subunit precursor [GO:0030687]	ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]	11988.24205843985	0.00339768983514322	0.999999953038689	1
P40855	P40855	PEX19_HUMAN	Peroxisomal biogenesis factor 19 (33 kDa housekeeping protein) (Peroxin-19) (Peroxisomal farnesylated protein)	PEX19	chaperone-mediated protein folding [GO:0061077]; establishment of protein localization to peroxisome [GO:0072663]; negative regulation of lipid binding [GO:1900131]; peroxisome fission [GO:0016559]; peroxisome membrane biogenesis [GO:0016557]; peroxisome organization [GO:0007031]; protein import into peroxisome membrane [GO:0045046]; protein stabilization [GO:0050821]; protein targeting to peroxisome [GO:0006625]	brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]	ATPase binding [GO:0051117]; peroxisome membrane class-1 targeting sequence binding [GO:0036105]; peroxisome membrane targeting sequence binding [GO:0033328]; protein carrier chaperone [GO:0140597]	17897.428468805	0.104922322976631	0.784331785569573	1
P50542	P50542	PEX5_HUMAN	Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1)	PEX5	cell development [GO:0048468]; cellular response to reactive oxygen species [GO:0034614]; cerebral cortex cell migration [GO:0021795]; cerebral cortex neuron differentiation [GO:0021895]; endoplasmic reticulum organization [GO:0007029]; fatty acid beta-oxidation [GO:0006635]; mitochondrial membrane organization [GO:0007006]; negative regulation of protein-containing complex assembly [GO:0031333]; neuromuscular process [GO:0050905]; neuron migration [GO:0001764]; pexophagy [GO:0000425]; positive regulation of multicellular organism growth [GO:0040018]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, docking [GO:0016560]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein import into peroxisome matrix, substrate release [GO:0044721]; protein import into peroxisome matrix, translocation [GO:0016561]; protein import into peroxisome membrane [GO:0045046]; protein targeting to peroxisome [GO:0006625]; protein tetramerization [GO:0051262]; very long-chain fatty acid metabolic process [GO:0000038]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]	enzyme binding [GO:0019899]; peroxisome matrix targeting signal-1 binding [GO:0005052]; peroxisome membrane targeting sequence binding [GO:0033328]; peroxisome targeting sequence binding [GO:0000268]; protein carrier chaperone [GO:0140597]; small GTPase binding [GO:0031267]	5696.23915762612	0.0414529899276101	0.998537746875667	1
Q16875	Q16875	F263_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (6PF-2-K/Fru-2,6-P2ase 3) (PFK/FBPase 3) (6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme) (Renal carcinoma antigen NY-REN-56) (iPFK-2) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]	PFKFB3	fructose 2,6-bisphosphate metabolic process [GO:0006003]; fructose metabolic process [GO:0006000]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]	6-phosphofructo-2-kinase activity [GO:0003873]; ATP binding [GO:0005524]; fructose-2,6-bisphosphate 2-phosphatase activity [GO:0004331]	18017.38282599595	-0.0388942277091543	0.979319597191842	1
Q16877	Q16877	F264_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (6PF-2-K/Fru-2,6-P2ase 4) (PFK/FBPase 4) (6PF-2-K/Fru-2,6-P2ase testis-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]	PFKFB4	fructose 2,6-bisphosphate metabolic process [GO:0006003]; fructose metabolic process [GO:0006000]	cytosol [GO:0005829]	6-phosphofructo-2-kinase activity [GO:0003873]; ATP binding [GO:0005524]; fructose-2,6-bisphosphate 2-phosphatase activity [GO:0004331]	4765.417013219991	-0.362660774655737	0.69024384064328	1
P17858	P17858	PFKAL_HUMAN	ATP-dependent 6-phosphofructokinase, liver type (ATP-PFK) (PFK-L) (EC 2.7.1.11) (6-phosphofructokinase type B) (Phosphofructo-1-kinase isozyme B) (PFK-B) (Phosphohexokinase)	PFKL	canonical glycolysis [GO:0061621]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]; glycolytic process [GO:0006096]; negative regulation of insulin secretion [GO:0046676]; response to glucose [GO:0009749]	6-phosphofructokinase complex [GO:0005945]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; secretory granule lumen [GO:0034774]	6-phosphofructokinase activity [GO:0003872]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; fructose binding [GO:0070061]; fructose-6-phosphate binding [GO:0070095]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; monosaccharide binding [GO:0048029]	133300.025976393	0.0241049271090934	0.999999776730116	1
P35080	P35080	PROF2_HUMAN	Profilin-2 (Profilin II)	PFN2	actin cytoskeleton organization [GO:0030036]; modification of postsynaptic actin cytoskeleton [GO:0098885]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of ruffle assembly [GO:1900028]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of stress fiber assembly [GO:0051496]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein stabilization [GO:0050821]; regulation of actin filament polymerization [GO:0030833]; regulation of synaptic vesicle exocytosis [GO:2000300]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]	actin binding [GO:0003779]; actin monomer binding [GO:0003785]; ATP hydrolysis activity [GO:0016887]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	134975.7597513335	-0.0181033352212142	0.99147436702234	1
P53609	P53609	PGTB1_HUMAN	Geranylgeranyl transferase type-1 subunit beta (EC 2.5.1.59) (Geranylgeranyl transferase type I subunit beta) (GGTase-I-beta) (Type I protein geranyl-geranyltransferase subunit beta)	PGGT1B	protein geranylgeranylation [GO:0018344]	CAAX-protein geranylgeranyltransferase complex [GO:0005953]	CAAX-protein geranylgeranyltransferase activity [GO:0004662]; protein geranylgeranyltransferase activity [GO:0004661]; zinc ion binding [GO:0008270]	7682.505892094425	0.0464444521273525	0.98097097481331	1
O95394	O95394	AGM1_HUMAN	Phosphoacetylglucosamine mutase (PAGM) (EC 5.4.2.3) (Acetylglucosamine phosphomutase) (N-acetylglucosamine-phosphate mutase) (Phosphoglucomutase-3) (PGM 3)	PGM3	carbohydrate metabolic process [GO:0005975]; glucosamine metabolic process [GO:0006041]; hemopoiesis [GO:0030097]; protein N-linked glycosylation [GO:0006487]; protein O-linked glycosylation [GO:0006493]; spermatogenesis [GO:0007283]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]	cytosol [GO:0005829]	magnesium ion binding [GO:0000287]; phosphoacetylglucosamine mutase activity [GO:0004610]	63307.33054415375	-0.0198172393658108	0.999996978593098	1
Q9NXJ5	Q9NXJ5	PGPI_HUMAN	Pyroglutamyl-peptidase 1 (EC 3.4.19.3) (5-oxoprolyl-peptidase) (Pyroglutamyl aminopeptidase I) (PAP-I) (Pyroglutamyl-peptidase I) (PGP-I) (Pyrrolidone-carboxylate peptidase)	PGPEP1	protein catabolic process [GO:0030163]; proteolysis [GO:0006508]	cytosol [GO:0005829]	pyroglutamyl-peptidase activity [GO:0016920]	10601.206237578801	0.0396009020871961	0.900149837854897	1
O15173	O15173	PGRC2_HUMAN	Membrane-associated progesterone receptor component 2 (Progesterone membrane-binding protein) (Steroid receptor protein DG6)	PGRMC2	adipose tissue development [GO:0060612]	endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]	heme binding [GO:0020037]; heme transmembrane transporter activity [GO:0015232]; nuclear steroid receptor activity [GO:0003707]; steroid binding [GO:0005496]	162740.9069517495	0.0953261451137275	0.938935420606498	1
Q8IWS0	Q8IWS0	PHF6_HUMAN	PHD finger protein 6 (PHD-like zinc finger protein)	PHF6	blastocyst hatching [GO:0001835]; negative regulation of transcription by RNA polymerase II [GO:0000122]	kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; phosphoprotein binding [GO:0051219]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]; tubulin binding [GO:0015631]	16371.996600815251	0.526110061476719	0.69797065186409	1
Q93100	Q93100	KPBB_HUMAN	Phosphorylase b kinase regulatory subunit beta (Phosphorylase kinase subunit beta)	PHKB	generation of precursor metabolites and energy [GO:0006091]; glycogen metabolic process [GO:0005977]	cytosol [GO:0005829]; phosphorylase kinase complex [GO:0005964]; plasma membrane [GO:0005886]	calmodulin binding [GO:0005516]	7887.797388434565	-0.153876993680758	0.965686836489065	1
Q8IUZ5	Q8IUZ5	AT2L2_HUMAN	5-phosphohydroxy-L-lysine phospho-lyase (EC 4.2.3.134) (Alanine--glyoxylate aminotransferase 2-like 2)	PHYKPL		mitochondrial matrix [GO:0005759]	identical protein binding [GO:0042802]; lyase activity [GO:0016829]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483]	8423.217727602574	0.250316911287546	0.818087760822345	1
P42356	P42356	PI4KA_HUMAN	Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) (Phosphatidylinositol 4-Kinase III alpha)	PI4KA	modulation by host of viral process [GO:0044788]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; reorganization of cellular membranes to establish viral sites of replication [GO:0140754]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi-associated vesicle membrane [GO:0030660]; membrane [GO:0016020]; plasma membrane [GO:0005886]	1-phosphatidylinositol 4-kinase activity [GO:0004430]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; kinase activity [GO:0016301]	5740.07397034454	-0.159327998219737	0.939927592033702	1
Q9UBF8	Q9UBF8	PI4KB_HUMAN	Phosphatidylinositol 4-kinase beta (PI4K-beta) (PI4Kbeta) (PtdIns 4-kinase beta) (EC 2.7.1.67) (NPIK) (PI4K92) (PI4KIII)	PI4KB	inner ear development [GO:0048839]; lysosome organization [GO:0007040]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; receptor-mediated endocytosis [GO:0006898]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; perinuclear region of cytoplasm [GO:0048471]; rough endoplasmic reticulum membrane [GO:0030867]	1-phosphatidylinositol 4-kinase activity [GO:0004430]; 14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]	4425.411893582985	0.0933550911905195	0.7889150411905	1
Q7Z2X4	Q7Z2X4	PCLI1_HUMAN	PTB-containing, cubilin and LRP1-interacting protein (P-CLI1) (Phosphotyrosine interaction domain-containing protein 1) (Protein NYGGF4)	PID1	cellular response to cytokine stimulus [GO:0071345]; cellular response to fatty acid [GO:0071398]; cellular response to interleukin-6 [GO:0071354]; cellular response to leptin stimulus [GO:0044320]; cellular response to tumor necrosis factor [GO:0071356]; energy reserve metabolic process [GO:0006112]; mitochondrion organization [GO:0007005]; negative regulation of ATP biosynthetic process [GO:2001170]; negative regulation of glucose import [GO:0046325]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of fat cell proliferation [GO:0070346]; positive regulation of gene expression [GO:0010628]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mitochondrial fusion [GO:0010635]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of reactive oxygen species metabolic process [GO:2000377]	cytoplasm [GO:0005737]		7007.05243990086	0.221390098164993	0.684635712897841	1
Q92508	Q92508	PIEZ1_HUMAN	Piezo-type mechanosensitive ion channel component 1 (Membrane protein induced by beta-amyloid treatment) (Mib) (Protein FAM38A)	PIEZO1	cellular response to mechanical stimulus [GO:0071260]; detection of mechanical stimulus [GO:0050982]; monoatomic cation transport [GO:0006812]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; positive regulation of integrin activation [GO:0033625]; positive regulation of myotube differentiation [GO:0010831]; regulation of membrane potential [GO:0042391]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; lamellipodium membrane [GO:0031258]; plasma membrane [GO:0005886]	mechanosensitive monoatomic cation channel activity [GO:0140135]; mechanosensitive monoatomic ion channel activity [GO:0008381]; monoatomic cation channel activity [GO:0005261]	9879.438374258454	-0.0769618680109435	0.998715134321431	1
Q92643	Q92643	GPI8_HUMAN	GPI-anchor transamidase (GPI transamidase) (EC 3.-.-.-) (GPI8 homolog) (hGPI8) (Phosphatidylinositol-glycan biosynthesis class K protein) (PIG-K)	PIGK	attachment of GPI anchor to protein [GO:0016255]; proteolysis [GO:0006508]	endoplasmic reticulum membrane [GO:0005789]; GPI-anchor transamidase complex [GO:0042765]; membrane [GO:0016020]	GPI-anchor transamidase activity [GO:0003923]; protein disulfide isomerase activity [GO:0003756]	8217.09031972891	0.0504650682125085	0.975046600000172	1
O00443	O00443	P3C2A_HUMAN	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha)	PIK3C2A	cell migration [GO:0016477]; clathrin coat assembly [GO:0048268]; endocytosis [GO:0006897]; epidermal growth factor receptor signaling pathway [GO:0007173]; exocytosis [GO:0006887]; insulin receptor signaling pathway [GO:0008286]; membrane organization [GO:0061024]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of autophagy [GO:0010508]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; vascular associated smooth muscle contraction [GO:0014829]	clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; phosphatidylinositol 3-kinase complex [GO:0005942]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; vesicle [GO:0031982]	1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]; clathrin binding [GO:0030276]; phosphatidylinositol binding [GO:0035091]	8247.17290947596	-0.104665590148744	0.977904421054665	1
Q8NEB9	Q8NEB9	PK3C3_HUMAN	Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34)	PIK3C3	autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to glucose starvation [GO:0042149]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; macroautophagy [GO:0016236]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; positive regulation by host of viral genome replication [GO:0044829]; protein lipidation [GO:0006497]; protein localization to phagophore assembly site [GO:0034497]; protein targeting to lysosome [GO:0006622]; regulation of autophagy [GO:0010506]; regulation of cytokinesis [GO:0032465]; regulation of macroautophagy [GO:0016241]	autolysosome [GO:0044754]; autophagosome [GO:0005776]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; late endosome [GO:0005770]; membrane [GO:0016020]; midbody [GO:0030496]; peroxisome [GO:0005777]; phagocytic vesicle membrane [GO:0030670]; phagophore assembly site [GO:0000407]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]	1-phosphatidylinositol-3-kinase activity [GO:0016303]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; phosphatidylinositol kinase activity [GO:0052742]; protein kinase activity [GO:0004672]	5185.0131777171755	0.0900688216118307	0.929256097454131	1
Q99570	Q99570	PI3R4_HUMAN	Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein)	PIK3R4	autophagosome maturation [GO:0097352]; cellular response to glucose starvation [GO:0042149]; early endosome to late endosome transport [GO:0045022]; late endosome to vacuole transport [GO:0045324]; macroautophagy [GO:0016236]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; protein phosphorylation [GO:0006468]; protein targeting to lysosome [GO:0006622]; protein targeting to vacuole [GO:0006623]; receptor catabolic process [GO:0032801]; regulation of autophagy [GO:0010506]; regulation of cytokinesis [GO:0032465]; regulation of macroautophagy [GO:0016241]	autophagosome [GO:0005776]; axoneme [GO:0005930]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleus-vacuole junction [GO:0071561]; phagocytic vesicle membrane [GO:0030670]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	3892.5854441319752	-0.0424150611160894	0.999999928958951	1
P78356	P78356	PI42B_HUMAN	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta)	PIP4K2B	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process [GO:1902635]; autophagosome-lysosome fusion [GO:0061909]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of insulin receptor signaling pathway [GO:0046627]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]; positive regulation of autophagosome assembly [GO:2000786]; regulation of autophagy [GO:0010506]	autophagosome [GO:0005776]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; protein homodimerization activity [GO:0042803]	10674.193269019801	0.0162097294133102	0.998958660461911	1
Q8TBX8	Q8TBX8	PI42C_HUMAN	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma)	PIP4K2C	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process [GO:1902635]; negative regulation of insulin receptor signaling pathway [GO:0046627]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]; positive regulation of autophagosome assembly [GO:2000786]; regulation of autophagy [GO:0010506]	autophagosome [GO:0005776]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; intracellular organelle [GO:0043229]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]	13320.7522628611	0.0431336746810822	0.889646614409615	1
O60331	O60331	PI51C_HUMAN	Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1gamma) (PtdIns(4)P-5-kinase 1 gamma) (EC 2.7.1.68) (Type I phosphatidylinositol 4-phosphate 5-kinase gamma)	PIP5K1C	actin cytoskeleton organization [GO:0030036]; adherens junction assembly [GO:0034333]; cell-cell adhesion [GO:0098609]; clathrin-dependent endocytosis [GO:0072583]; membrane organization [GO:0061024]; neutrophil chemotaxis [GO:0030593]; phagocytosis [GO:0006909]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphorylation [GO:0016310]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle exocytosis [GO:0016079]	adherens junction [GO:0005912]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; ruffle membrane [GO:0032587]; uropod [GO:0001931]	1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; ATP binding [GO:0005524]; phosphatidylinositol kinase activity [GO:0052742]	9484.721724481155	0.0175825782577619	0.99296437915483	1
O00625	O00625	PIR_HUMAN	Pirin (EC 1.13.11.24) (Probable quercetin 2,3-dioxygenase PIR) (Probable quercetinase)	PIR	digestion [GO:0007586]; monocyte differentiation [GO:0030224]; transcription by RNA polymerase II [GO:0006366]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; quercetin 2,3-dioxygenase activity [GO:0008127]; transcription coregulator activity [GO:0003712]	19074.2897398997	-0.818633048183176	0.977530688976894	1
O00562	O00562	PITM1_HUMAN	Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2)	PITPNM1	brain development [GO:0007420]; lipid metabolic process [GO:0006629]; phosphatidylinositol biosynthetic process [GO:0006661]; phospholipid transport [GO:0015914]; phototransduction [GO:0007602]; protein transport [GO:0015031]	cell body [GO:0044297]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi cisterna membrane [GO:0032580]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; membrane [GO:0016020]; midbody [GO:0030496]	calcium ion binding [GO:0005509]; phosphatidic acid binding [GO:0070300]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transporter activity [GO:0008525]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526]; receptor tyrosine kinase binding [GO:0030971]	2344.14929509086	0.377037879198679	0.688994097385519	1
Q5JRX3	Q5JRX3	PREP_HUMAN	Presequence protease, mitochondrial (hPreP) (EC 3.4.24.-) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1)	PITRM1	protein processing [GO:0016485]; protein targeting to mitochondrion [GO:0006626]; proteolysis [GO:0006508]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	enzyme activator activity [GO:0008047]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]	12145.865138150999	0.028649462929826	0.999992907912458	1
Q13563	Q13563	PKD2_HUMAN	Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2)	PKD2	aorta development [GO:0035904]; branching involved in ureteric bud morphogenesis [GO:0001658]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cell-cell signaling by wnt [GO:0198738]; cellular response to calcium ion [GO:0071277]; cellular response to cAMP [GO:0071320]; cellular response to fluid shear stress [GO:0071498]; cellular response to hydrostatic pressure [GO:0071464]; cellular response to osmotic stress [GO:0071470]; cellular response to reactive oxygen species [GO:0034614]; centrosome duplication [GO:0051298]; cilium organization [GO:0044782]; detection of mechanical stimulus [GO:0050982]; detection of nodal flow [GO:0003127]; determination of left/right symmetry [GO:0007368]; determination of liver left/right asymmetry [GO:0071910]; embryonic placenta development [GO:0001892]; establishment of localization in cell [GO:0051649]; heart development [GO:0007507]; heart looping [GO:0001947]; inorganic cation transmembrane transport [GO:0098662]; intracellular calcium ion homeostasis [GO:0006874]; liver development [GO:0001889]; mesonephric duct development [GO:0072177]; mesonephric tubule development [GO:0072164]; metanephric ascending thin limb development [GO:0072218]; metanephric cortex development [GO:0072214]; metanephric cortical collecting duct development [GO:0072219]; metanephric distal tubule development [GO:0072235]; metanephric mesenchyme development [GO:0072075]; metanephric part of ureteric bud development [GO:0035502]; metanephric S-shaped body morphogenesis [GO:0072284]; metanephric smooth muscle tissue development [GO:0072208]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; neural tube development [GO:0021915]; placenta blood vessel development [GO:0060674]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031587]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of transcription by RNA polymerase II [GO:0045944]; potassium ion transmembrane transport [GO:0071805]; protein heterotetramerization [GO:0051290]; protein homotetramerization [GO:0051289]; protein tetramerization [GO:0051262]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of calcium ion import [GO:0090279]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; release of sequestered calcium ion into cytosol [GO:0051209]; renal artery morphogenesis [GO:0061441]; renal tubule morphogenesis [GO:0061333]; sodium ion transmembrane transport [GO:0035725]; spinal cord development [GO:0021510]; Wnt signaling pathway [GO:0016055]	basal cortex [GO:0045180]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cation channel complex [GO:0034703]; cell-cell junction [GO:0005911]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; migrasome [GO:0140494]; mitotic spindle [GO:0072686]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]; polycystin complex [GO:0002133]	actinin binding [GO:0042805]; ATPase binding [GO:0051117]; calcium ion binding [GO:0005509]; calcium-induced calcium release activity [GO:0048763]; cytoskeletal protein binding [GO:0008092]; HLH domain binding [GO:0043398]; identical protein binding [GO:0042802]; monoatomic cation channel activity [GO:0005261]; muscle alpha-actinin binding [GO:0051371]; outward rectifier potassium channel activity [GO:0015271]; phosphoprotein binding [GO:0051219]; potassium channel activity [GO:0005267]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; transcription regulator inhibitor activity [GO:0140416]; transmembrane transporter binding [GO:0044325]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated monoatomic ion channel activity [GO:0005244]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated sodium channel activity [GO:0005248]	6549.455318092855	-0.137697508931576	0.823076237929135	1
Q16513	Q16513	PKN2_HUMAN	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2)	PKN2	apical junction assembly [GO:0043297]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell projection organization [GO:0030030]; epithelial cell migration [GO:0010631]; intracellular signal transduction [GO:0035556]; positive regulation of cytokinesis [GO:0032467]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of viral genome replication [GO:0045070]; protein phosphorylation [GO:0006468]; regulation of cell motility [GO:2000145]; signal transduction [GO:0007165]	apical junction complex [GO:0043296]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; lamellipodium [GO:0030027]; midbody [GO:0030496]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	ATP binding [GO:0005524]; cadherin binding [GO:0045296]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; histone deacetylase binding [GO:0042826]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]; small GTPase binding [GO:0031267]	9731.924166766541	-0.119880423420856	0.982547610781087	1
Q9Y263	Q9Y263	PLAP_HUMAN	Phospholipase A-2-activating protein (PLA2P) (PLAP)	PLAA	cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; macroautophagy [GO:0016236]; negative regulation of protein K63-linked ubiquitination [GO:1900045]; nervous system development [GO:0007399]; phospholipid metabolic process [GO:0006644]; positive regulation of dendrite extension [GO:1903861]; positive regulation of neuron migration [GO:2001224]; positive regulation of phospholipase A2 activity [GO:0032430]; positive regulation of synaptic vesicle recycling [GO:1903423]; prostaglandin metabolic process [GO:0006693]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; signal transduction [GO:0007165]; ubiquitin recycling [GO:0010992]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; synapse [GO:0045202]	phospholipase A2 activator activity [GO:0016005]; ubiquitin binding [GO:0043130]	27294.6949813941	0.0256640298365824	0.999739872413645	1
P51178	P51178	PLCD1_HUMAN	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-1) (Phospholipase C-III) (PLC-III) (Phospholipase C-delta-1) (PLC-delta-1)	PLCD1	lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipid metabolic process [GO:0006644]; release of sequestered calcium ion into cytosol [GO:0051209]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	calcium ion binding [GO:0005509]; GTPase activating protein binding [GO:0032794]; phosphatidylinositol phospholipase C activity [GO:0004435]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	12857.131933841702	-0.0299028063331837	0.9998258836592	1
Q8N3E9	Q8N3E9	PLCD3_HUMAN	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3)	PLCD3	angiogenesis [GO:0001525]; labyrinthine layer blood vessel development [GO:0060716]; lipid catabolic process [GO:0016042]; phosphatidylinositol-mediated signaling [GO:0048015]; regulation of cell population proliferation [GO:0042127]; release of sequestered calcium ion into cytosol [GO:0051209]	cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	metal ion binding [GO:0046872]; phosphatidylinositol phospholipase C activity [GO:0004435]	6136.516531221019	-0.105019271521593	0.937412857025928	1
Q9HB19	Q9HB19	PKHA2_HUMAN	Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (Tandem PH domain-containing protein 2) (TAPP-2)	PLEKHA2	positive regulation of cell-matrix adhesion [GO:0001954]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	fibronectin binding [GO:0001968]; laminin binding [GO:0043236]; lipid binding [GO:0008289]; PDZ domain binding [GO:0030165]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]	6516.9092447893345	0.0867752257905959	0.983099446710263	1
Q9HB20	Q9HB20	PKHA3_HUMAN	Pleckstrin homology domain-containing family A member 3 (PH domain-containing family A member 3) (Phosphatidylinositol-four-phosphate adapter protein 1) (FAPP-1) (Phosphoinositol 4-phosphate adapter protein 1)	PLEKHA3	endosome organization [GO:0007032]; receptor recycling [GO:0001881]; retrograde transport, endosome to Golgi [GO:0042147]	cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802]	identical protein binding [GO:0042802]; phosphatidylinositol-4-phosphate binding [GO:0070273]	4989.846705504369	0.0879551276092754	0.997752417577181	1
Q8IWE5	Q8IWE5	PKHM2_HUMAN	Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2) (Salmonella-induced filaments A and kinesin-interacting protein) (SifA and kinesin-interacting protein)	PLEKHM2	Golgi organization [GO:0007030]; lysosome localization [GO:0032418]; natural killer cell mediated cytotoxicity [GO:0042267]; regulation of protein localization [GO:0032880]	endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]	kinesin binding [GO:0019894]	3249.5190425845403	0.107744197573894	0.993548187800548	1
Q8TD55	Q8TD55	PKHO2_HUMAN	Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1)	PLEKHO2	macrophage apoptotic process [GO:0071888]	extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]		16202.184596214	0.0680209676355504	0.954396545084099	1
Q02809	Q02809	PLOD1_HUMAN	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (EC 1.14.11.4) (Lysyl hydroxylase 1) (LH1)	PLOD1	epidermis development [GO:0008544]; peptidyl-lysine hydroxylation [GO:0017185]; response to hypoxia [GO:0001666]	catalytic complex [GO:1902494]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; rough endoplasmic reticulum membrane [GO:0030867]	iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-lysine 5-dioxygenase activity [GO:0008475]	232680.919589571	-0.0403277625272013	0.993909450182448	1
O14494	O14494	PLPP1_HUMAN	Phospholipid phosphatase 1 (EC 3.1.3.-) (EC 3.1.3.106) (EC 3.1.3.4) (EC 3.6.1.75) (Lipid phosphate phosphohydrolase 1) (PAP2-alpha) (Phosphatidate phosphohydrolase type 2a) (Phosphatidic acid phosphatase 2a) (PAP-2a) (PAP2a)	PLPP1	androgen receptor signaling pathway [GO:0030521]; ceramide metabolic process [GO:0006672]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; negative regulation of cell population proliferation [GO:0008285]; phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of lipid metabolic process [GO:0019216]; signal transduction [GO:0007165]; sphingolipid catabolic process [GO:0030149]; sphingosine metabolic process [GO:0006670]	apical plasma membrane [GO:0016324]; caveola [GO:0005901]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	ceramide-1-phosphate phosphatase activity [GO:0106235]; diacylglycerol diphosphate phosphatase activity [GO:0000810]; lipid phosphatase activity [GO:0042577]; lysophosphatidic acid phosphatase activity [GO:0052642]; phosphatidate phosphatase activity [GO:0008195]; sphingosine-1-phosphate phosphatase activity [GO:0042392]	35800.234993261445	-0.0739879396118603	0.858186176617622	1
O43660	O43660	PLRG1_HUMAN	Pleiotropic regulator 1	PLRG1	mRNA splicing, via spliceosome [GO:0000398]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; protein localization to nucleus [GO:0034504]	catalytic step 2 spliceosome [GO:0071013]; fibrillar center [GO:0001650]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007]		6660.308698327125	-0.0854755760747619	0.929640332920961	1
Q14651	Q14651	PLSI_HUMAN	Plastin-1 (Intestine-specific plastin) (I-plastin)	PLS1	actin filament bundle assembly [GO:0051017]; actin filament network formation [GO:0051639]; auditory receptor cell stereocilium organization [GO:0060088]; intestinal D-glucose absorption [GO:0001951]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of microvillus length [GO:0032532]; terminal web assembly [GO:1902896]; vestibular receptor cell stereocilium organization [GO:0060121]	actin filament [GO:0005884]; actin filament bundle [GO:0032432]; brush border [GO:0005903]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; terminal web [GO:1990357]	actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; structural constituent of cytoskeleton [GO:0005200]	29276.81449572685	0.029868483205645	0.962535425090986	1
O75051	O75051	PLXA2_HUMAN	Plexin-A2 (Semaphorin receptor OCT)	PLXNA2	centrosome localization [GO:0051642]; cerebellar granule cell precursor tangential migration [GO:0021935]; limb bud formation [GO:0060174]; negative regulation of cell adhesion [GO:0007162]; neural tube development [GO:0021915]; pharyngeal system development [GO:0060037]; positive regulation of axonogenesis [GO:0050772]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; somitogenesis [GO:0001756]	plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116]	identical protein binding [GO:0042802]; semaphorin receptor activity [GO:0017154]	4488.0107381404305	-0.0555861967848194	0.997765302285767	1
O15305	O15305	PMM2_HUMAN	Phosphomannomutase 2 (PMM 2) (EC 5.4.2.8)	PMM2	GDP-mannose biosynthetic process [GO:0009298]; mannose metabolic process [GO:0006013]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]	cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]	metal ion binding [GO:0046872]; phosphomannomutase activity [GO:0004615]	36127.3331348191	-0.0163278276406495	0.999709954182388	1
Q10713	Q10713	MPPA_HUMAN	Mitochondrial-processing peptidase subunit alpha (Alpha-MPP) (Inactive zinc metalloprotease alpha) (P-55)	PMPCA	protein processing involved in protein targeting to mitochondrion [GO:0006627]	extracellular space [GO:0005615]; mitochondrial inner membrane [GO:0005743]; mitochondrial processing peptidase complex [GO:0017087]; mitochondrion [GO:0005739]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	7957.15455693714	0.0695659767478411	0.789399856963365	1
O75439	O75439	MPPB_HUMAN	Mitochondrial-processing peptidase subunit beta (EC 3.4.24.64) (Beta-MPP) (P-52)	PMPCB	mitochondrial calcium ion transmembrane transport [GO:0006851]; protein processing involved in protein targeting to mitochondrion [GO:0006627]	mitochondrial inner membrane [GO:0005743]; mitochondrial processing peptidase complex [GO:0017087]; mitochondrion [GO:0005739]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	15204.3506520782	0.0756602949271024	0.734922902326467	1
Q96T60	Q96T60	PNKP_HUMAN	Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)]	PNKP	base-excision repair, gap-filling [GO:0006287]; DNA ligation involved in DNA repair [GO:0051103]; DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261]; double-strand break repair via nonhomologous end joining [GO:0006303]; negative regulation of protein ADP-ribosylation [GO:0010836]; nucleotide-excision repair [GO:0006289]; phosphorylation [GO:0016310]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; response to oxidative stress [GO:0006979]; response to radiation [GO:0009314]	membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	ATP binding [GO:0005524]; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [GO:0046404]; damaged DNA binding [GO:0003684]; double-stranded DNA binding [GO:0003690]; endonuclease activity [GO:0004519]; polynucleotide 3'-phosphatase activity [GO:0046403]; purine nucleotide binding [GO:0017076]	5384.648164089251	-0.205695086572871	0.76997175517829	1
Q9H307	Q9H307	PININ_HUMAN	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Desmosome-associated protein) (Domain-rich serine protein) (DRS protein) (DRSP) (Melanoma metastasis clone A protein) (Nuclear protein SDK3) (SR-like protein)	PNN	cell adhesion [GO:0007155]; mRNA splicing, via spliceosome [GO:0000398]	catalytic step 2 spliceosome [GO:0071013]; cell-cell junction [GO:0005911]; desmosome [GO:0030057]; intermediate filament [GO:0005882]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	DNA binding [GO:0003677]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]	10677.572381132999	0.0548498971690615	0.930083564514904	1
Q9NRX1	Q9NRX1	PNO1_HUMAN	RNA-binding protein PNO1 (Partner of NOB1)	PNO1	ribosomal small subunit biogenesis [GO:0042274]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	RNA binding [GO:0003723]	13349.6796328704	-0.0182487085391454	0.987692811592297	1
P00491	P00491	PNPH_HUMAN	Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase)	PNP	allantoin metabolic process [GO:0000255]; dAMP catabolic process [GO:0046059]; deoxyadenosine catabolic process [GO:0006157]; deoxyinosine catabolic process [GO:0006149]; immune response [GO:0006955]; IMP catabolic process [GO:0006204]; inosine catabolic process [GO:0006148]; nicotinamide riboside catabolic process [GO:0006738]; nucleobase-containing compound metabolic process [GO:0006139]; nucleotide biosynthetic process [GO:0009165]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of T cell proliferation [GO:0042102]; purine ribonucleoside salvage [GO:0006166]; purine-containing compound salvage [GO:0043101]; response to xenobiotic stimulus [GO:0009410]; urate biosynthetic process [GO:0034418]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]	guanosine phosphorylase activity [GO:0047975]; identical protein binding [GO:0042802]; nucleoside binding [GO:0001882]; phosphate ion binding [GO:0042301]; purine nucleobase binding [GO:0002060]; purine-nucleoside phosphorylase activity [GO:0004731]	123378.085953313	0.0267553753803264	0.999562115096144	1
Q7Z3K3	Q7Z3K3	POGZ_HUMAN	Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635)	POGZ	cell division [GO:0051301]; double-strand break repair via homologous recombination [GO:0000724]; kinetochore assembly [GO:0051382]; mitotic sister chromatid cohesion [GO:0007064]; positive regulation of transcription by RNA polymerase II [GO:0045944]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]	2756.16260915276	-0.214755911367244	0.743203688894718	1
Q9Y2S7	Q9Y2S7	PDIP2_HUMAN	Polymerase delta-interacting protein 2 (38 kDa DNA polymerase delta interaction protein) (p38)	POLDIP2	error-free translesion synthesis [GO:0070987]; mitochondrion organization [GO:0007005]; mitotic spindle assembly [GO:0090307]; negative regulation of macroautophagy [GO:0016242]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of mitotic cytokinesis [GO:1903490]; vascular associated smooth muscle cell proliferation [GO:1990874]	cell-cell junction [GO:0005911]; midbody [GO:0030496]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]	DNA binding [GO:0003677]	10052.778943661498	0.193089054953985	0.778399759480375	1
P24928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	POLR2A	DNA-templated transcription termination [GO:0006353]; positive regulation of RNA splicing [GO:0033120]; regulation of DNA-templated transcription [GO:0006355]; transcription by RNA polymerase II [GO:0006366]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]	DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; hydrolase activity [GO:0016787]; kinase binding [GO:0019900]; magnesium ion binding [GO:0000287]; microfibril binding [GO:0050436]; promoter-specific chromatin binding [GO:1990841]; RNA binding [GO:0003723]; RNA polymerase II activity [GO:0001055]; RNA-dependent RNA polymerase activity [GO:0003968]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	4567.51539123941	-0.0434888296066086	0.999978420499943	1
P30876	P30876	RPB2_HUMAN	DNA-directed RNA polymerase II subunit RPB2 (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II 140 kDa polypeptide) (DNA-directed RNA polymerase II subunit B) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2) (RNA-directed RNA polymerase II subunit RPB2) (EC 2.7.7.48)	POLR2B	transcription by RNA polymerase II [GO:0006366]	membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; ribonucleoside binding [GO:0032549]; RNA binding [GO:0003723]; RNA polymerase II activity [GO:0001055]; RNA-dependent RNA polymerase activity [GO:0003968]	8564.85522763306	-0.188318314514877	0.911421820118158	1
O15514	O15514	RPB4_HUMAN	DNA-directed RNA polymerase II subunit RPB4 (RNA polymerase II subunit B4) (DNA-directed RNA polymerase II subunit D) (RNA polymerase II 16 kDa subunit) (RPB16)	POLR2D	recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex [GO:0034402]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]	nucleotide binding [GO:0000166]; translation initiation factor binding [GO:0031369]	8599.126511667891	0.176510858251304	0.732435812992515	1
P19388	P19388	RPAB1_HUMAN	DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RNA polymerases I, II, and III subunit ABC1) (DNA-directed RNA polymerase II 23 kDa polypeptide) (DNA-directed RNA polymerase II subunit E) (RPB5 homolog) (XAP4)	POLR2E	protein stabilization [GO:0050821]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase I [GO:0006362]; tRNA transcription by RNA polymerase III [GO:0042797]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase I complex [GO:0005736]; RNA polymerase II, core complex [GO:0005665]; RNA polymerase III complex [GO:0005666]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]	DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; RNA polymerase I activity [GO:0001054]; RNA polymerase II activity [GO:0001055]; RNA polymerase III activity [GO:0001056]	19444.125117851	0.0953773479855219	0.869449143910329	1
A8CG34	A8CG34	P121C_HUMAN	Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C)	POM121C	mRNA transport [GO:0051028]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405]	endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]	nuclear localization sequence binding [GO:0008139]; structural constituent of nuclear pore [GO:0017056]	7690.366648850455	0.1461676619167	0.867411218139735	1
Q8WZA1	Q8WZA1	PMGT1_HUMAN	Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMGnT1) (EC 2.4.1.-) (UDP-GlcNAc:alpha-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.2) (GnT I.2)	POMGNT1	basement membrane organization [GO:0071711]; dentate gyrus development [GO:0021542]; gene expression [GO:0010467]; localization of cell [GO:0051674]; myelination [GO:0042552]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked mannosylation [GO:0035269]; reactive gliosis [GO:0150103]; sensory perception of sound [GO:0007605]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	acetylglucosaminyltransferase activity [GO:0008375]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity [GO:0047223]; carbohydrate binding [GO:0030246]; manganese ion binding [GO:0030145]	4341.02270807283	-0.25961776795247	0.999631134375479	1
Q99575	Q99575	POP1_HUMAN	Ribonucleases P/MRP protein subunit POP1 (hPOP1)	POP1	tRNA 5'-leader removal [GO:0001682]; tRNA catabolic process [GO:0016078]; tRNA processing [GO:0008033]	extracellular space [GO:0005615]; multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonuclease MRP complex [GO:0000172]	ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]; RNA binding [GO:0003723]	6577.95232590063	-0.0931036154313298	0.897209665601508	1
O95707	O95707	RPP29_HUMAN	Ribonuclease P protein subunit p29 (hPOP4)	POP4	rRNA processing [GO:0006364]; tRNA 5'-leader removal [GO:0001682]	multimeric ribonuclease P complex [GO:0030681]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonuclease MRP complex [GO:0000172]; ribonuclease P complex [GO:0030677]	ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]	4581.378676677325	-0.111584809441272	0.854051232042373	1
P16435	P16435	NCPR_HUMAN	NADPH--cytochrome P450 reductase (CPR) (P450R) (EC 1.6.2.4)	POR	cellular organofluorine metabolic process [GO:0090346]; electron transport chain [GO:0022900]; positive regulation of monooxygenase activity [GO:0032770]; response to hormone [GO:0009725]; xenobiotic metabolic process [GO:0006805]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; NADP binding [GO:0050661]; NADPH-hemoprotein reductase activity [GO:0003958]	21681.70466291665	-0.00119545357135683	1	1
Q06203	Q06203	PUR1_HUMAN	Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPAT)	PPAT	'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; glutamine metabolic process [GO:0006541]; GMP biosynthetic process [GO:0006177]; purine nucleobase biosynthetic process [GO:0009113]; purine nucleotide biosynthetic process [GO:0006164]	cytosol [GO:0005829]	4 iron, 4 sulfur cluster binding [GO:0051539]; amidophosphoribosyltransferase activity [GO:0004044]; metal ion binding [GO:0046872]	14467.309401170049	-0.0535608042265298	0.999923548225263	1
Q9H3Y8	Q9H3Y8	PPDPF_HUMAN	Pancreatic progenitor cell differentiation and proliferation factor (Exocrine differentiation and proliferation factor)	PPDPF	cell differentiation [GO:0030154]			6475.254751773875	-0.170490468767826	0.871077545577397	1
Q13136	Q13136	LIPA1_HUMAN	Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1)	PPFIA1	cell-matrix adhesion [GO:0007160]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of stress fiber assembly [GO:0051497]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; signal transduction [GO:0007165]; synapse organization [GO:0050808]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; presynaptic active zone [GO:0048786]; protein-containing complex [GO:0032991]; Schaffer collateral - CA1 synapse [GO:0098685]; spine apparatus [GO:0097444]		10253.45071095895	-0.0769026298985527	0.98904877866956	1
P45877	P45877	PPIC_HUMAN	Peptidyl-prolyl cis-trans isomerase C (PPIase C) (EC 5.2.1.8) (Cyclophilin C) (Rotamase C)	PPIC	protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	39520.6816180835	-0.112708279553731	0.942361771178244	1
Q9UNP9	Q9UNP9	PPIE_HUMAN	Peptidyl-prolyl cis-trans isomerase E (PPIase E) (EC 5.2.1.8) (Cyclophilin E) (Cyclophilin-33) (Rotamase E)	PPIE	mRNA splicing, via spliceosome [GO:0000398]; positive regulation of viral genome replication [GO:0045070]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; regulation of DNA-templated transcription [GO:0006355]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]; U2-type catalytic step 2 spliceosome [GO:0071007]	cyclosporin A binding [GO:0016018]; mRNA binding [GO:0003729]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; poly(A) binding [GO:0008143]; RNA binding [GO:0003723]	9712.054661525255	0.00911878719481919	0.999990829401959	1
Q13427	Q13427	PPIG_HUMAN	Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G)	PPIG	protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; RNA splicing [GO:0008380]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723]	10336.75906565445	-0.177732914586978	0.980887671523067	1
Q9Y3C6	Q9Y3C6	PPIL1_HUMAN	Peptidyl-prolyl cis-trans isomerase-like 1 (PPIase) (EC 5.2.1.8) (Rotamase PPIL1)	PPIL1	embryonic brain development [GO:1990403]; mRNA splicing, via spliceosome [GO:0000398]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]	catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 2 spliceosome [GO:0071007]	cyclosporin A binding [GO:0016018]; disordered domain specific binding [GO:0097718]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	53227.4410997744	-0.100604816257007	0.708048690093717	1
Q13356	Q13356	PPIL2_HUMAN	RING-type E3 ubiquitin-protein ligase PPIL2 (EC 2.3.2.27) (CYC4) (Cyclophilin-60) (Cyclophilin-like protein Cyp-60) (Cyp60) (hCyP-60) (Probable inactive peptidyl-prolyl cis-trans isomerase-like 2) (PPIase) (Rotamase PPIL2)	PPIL2	mRNA processing [GO:0006397]; protein folding [GO:0006457]; protein localization to plasma membrane [GO:0072659]; protein polyubiquitination [GO:0000209]; RNA splicing [GO:0008380]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; Golgi lumen [GO:0005796]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-ubiquitin ligase activity [GO:0034450]	2997.673803953175	-0.236093820046188	0.716268481915054	1
Q8WUA2	Q8WUA2	PPIL4_HUMAN	Peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) (EC 5.2.1.8) (Cyclophilin-like protein PPIL4) (Rotamase PPIL4)	PPIL4		cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723]	4535.294990809285	-0.0676814375307865	0.988912643167167	1
O75688	O75688	PPM1B_HUMAN	Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta)	PPM1B	N-terminal protein myristoylation [GO:0006499]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of defense response to virus [GO:0050687]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein dephosphorylation [GO:0006470]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]	magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]	17096.2937947451	0.111917682706463	0.925235554787111	1
O15355	O15355	PPM1G_HUMAN	Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma)	PPM1G	peptidyl-threonine dephosphorylation [GO:0035970]; protein dephosphorylation [GO:0006470]; regulation of cell cycle [GO:0051726]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]	12634.6156660709	0.0361099121874615	0.911652817742609	1
Q9Y570	Q9Y570	PPME1_HUMAN	Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89)	PPME1	G2/M transition of mitotic cell cycle [GO:0000086]; protein demethylation [GO:0006482]	nucleoplasm [GO:0005654]	cadherin binding [GO:0045296]; lncRNA binding [GO:0106222]; protein C-terminal methylesterase activity [GO:0051722]; protein kinase binding [GO:0019901]; protein methylesterase activity [GO:0051723]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase binding [GO:0019903]; protein phosphatase inhibitor activity [GO:0004864]; protein phosphatase regulator activity [GO:0019888]	44222.16491528015	0.0323385200932447	0.999933466654326	1
P50336	P50336	PPOX_HUMAN	Protoporphyrinogen oxidase (PPO) (EC 1.3.3.4)	PPOX	carotenoid biosynthetic process [GO:0016117]; heme A biosynthetic process [GO:0006784]; heme B biosynthetic process [GO:0006785]; heme biosynthetic process [GO:0006783]; heme O biosynthetic process [GO:0048034]; porphyrin-containing compound biosynthetic process [GO:0006779]; protoporphyrinogen IX biosynthetic process [GO:0006782]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]	flavin adenine dinucleotide binding [GO:0050660]; oxygen-dependent protoporphyrinogen oxidase activity [GO:0004729]; phytoene dehydrogenase activity [GO:0016166]	4467.75692846751	-0.146175933176758	0.88968052211778	1
P62136	P62136	PP1A_HUMAN	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)	PPP1CA	branching morphogenesis of an epithelial tube [GO:0048754]; cell cycle [GO:0007049]; cell division [GO:0051301]; circadian regulation of gene expression [GO:0032922]; dephosphorylation [GO:0016311]; entrainment of circadian clock by photoperiod [GO:0043153]; glycogen metabolic process [GO:0005977]; lung development [GO:0030324]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; protein dephosphorylation [GO:0006470]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of circadian rhythm [GO:0042752]; regulation of glycogen biosynthetic process [GO:0005979]; regulation of glycogen catabolic process [GO:0005981]; regulation of translational initiation [GO:0006446]; response to lead ion [GO:0010288]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; glycogen granule [GO:0042587]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; PTW/PP1 phosphatase complex [GO:0072357]	cadherin binding involved in cell-cell adhesion [GO:0098641]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; phosphoprotein phosphatase activity [GO:0004721]; protein phosphatase 1 binding [GO:0008157]; protein serine/threonine phosphatase activity [GO:0004722]; ribonucleoprotein complex binding [GO:0043021]	88070.70252377035	-0.105700318694566	0.802277257215139	1
P62140	P62140	PP1B_HUMAN	Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)	PPP1CB	cell cycle [GO:0007049]; cell division [GO:0051301]; circadian regulation of gene expression [GO:0032922]; entrainment of circadian clock by photoperiod [GO:0043153]; glycogen metabolic process [GO:0005977]; MAPK cascade [GO:0000165]; protein dephosphorylation [GO:0006470]; regulation of cell adhesion [GO:0030155]; regulation of circadian rhythm [GO:0042752]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PTW/PP1 phosphatase complex [GO:0072357]	metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; myosin-light-chain-phosphatase activity [GO:0050115]; phosphatase activity [GO:0016791]; protein kinase binding [GO:0019901]; protein serine/threonine phosphatase activity [GO:0004722]	49636.84322290255	-0.098959396437841	0.776904795379836	1
P36873	P36873	PP1G_HUMAN	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)	PPP1CC	blastocyst development [GO:0001824]; cell cycle [GO:0007049]; cell division [GO:0051301]; circadian regulation of gene expression [GO:0032922]; entrainment of circadian clock by photoperiod [GO:0043153]; glycogen metabolic process [GO:0005977]; MAPK cascade [GO:0000165]; neuron differentiation [GO:0030182]; positive regulation of glial cell proliferation [GO:0060252]; protein dephosphorylation [GO:0006470]; regulation of circadian rhythm [GO:0042752]; regulation of nucleocytoplasmic transport [GO:0046822]; spermatogenesis [GO:0007283]	cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; kinetochore [GO:0000776]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; presynapse [GO:0098793]; protein-containing complex [GO:0032991]; PTW/PP1 phosphatase complex [GO:0072357]	lamin binding [GO:0005521]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; phosphoprotein phosphatase activity [GO:0004721]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein phosphatase 1 binding [GO:0008157]; protein serine/threonine phosphatase activity [GO:0004722]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]	44787.99029789875	-0.0798043522501668	0.716466631149865	1
Q96QC0	Q96QC0	PP1RA_HUMAN	Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (PP1-binding protein of 114 kDa) (Phosphatase 1 nuclear targeting subunit) (Protein FB19) (p99)	PPP1R10	negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of mitotic DNA damage checkpoint [GO:1904290]; positive regulation of telomere maintenance [GO:0032206]; protein import into nucleus [GO:0006606]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PTW/PP1 phosphatase complex [GO:0072357]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase inhibitor activity [GO:0004864]; RNA binding [GO:0003723]	2823.354746463835	0.0814564180154489	0.978036251535799	1
Q9BZL4	Q9BZL4	PP12C_HUMAN	Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85)	PPP1R12C	signal transduction [GO:0007165]	cytoplasm [GO:0005737]; stress fiber [GO:0001725]	enzyme inhibitor activity [GO:0004857]; phosphatase regulator activity [GO:0019208]; protein kinase binding [GO:0019901]	15432.6791068313	-0.00871190023192318	0.999999999997726	1
Q96C90	Q96C90	PP14B_HUMAN	Protein phosphatase 1 regulatory subunit 14B (Phospholipase C-beta-3 neighbouring gene protein)	PPP1R14B	innate immune response [GO:0045087]; regulation of phosphorylation [GO:0042325]	cytoplasm [GO:0005737]	protein serine/threonine phosphatase inhibitor activity [GO:0004865]	70747.91606398555	0.0269683774419742	0.99909542779885	1
Q6NYC8	Q6NYC8	PPR18_HUMAN	Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18)	PPP1R18		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	actin binding [GO:0003779]; phosphatase binding [GO:0019902]	31247.75289036055	-0.148779795335814	0.992783209660067	1
Q15435	Q15435	PP1R7_HUMAN	Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22)	PPP1R7	positive regulation of protein dephosphorylation [GO:0035307]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	enzyme regulator activity [GO:0030234]; protein phosphatase regulator activity [GO:0019888]	68446.20749301091	0.140066847697436	0.668641664214998	1
Q12972	Q12972	PP1R8_HUMAN	Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8) [Includes: Activator of RNA decay (EC 3.1.4.-) (ARD-1)]	PPP1R8	cell population proliferation [GO:0008283]; maintenance of RNA location [GO:0051237]; miRNA processing [GO:0035196]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of protein dephosphorylation [GO:0035308]; RNA catabolic process [GO:0006401]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; molecular function inhibitor activity [GO:0140678]; mRNA binding [GO:0003729]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; ribonuclease E activity [GO:0008995]; RNA binding [GO:0003723]	12461.8133646957	0.161488454398948	0.706442895037648	1
Q96SB3	Q96SB3	NEB2_HUMAN	Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin)	PPP1R9B	actin filament depolymerization [GO:0030042]; actin filament organization [GO:0007015]; calcium-mediated signaling [GO:0019722]; cell migration [GO:0016477]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to estradiol stimulus [GO:0071392]; cellular response to morphine [GO:0071315]; cellular response to peptide [GO:1901653]; cellular response to xenobiotic stimulus [GO:0071466]; cerebral cortex development [GO:0021987]; dendrite development [GO:0016358]; developmental process involved in reproduction [GO:0003006]; filopodium assembly [GO:0046847]; hippocampus development [GO:0021766]; learning [GO:0007612]; male mating behavior [GO:0060179]; negative regulation of cell growth [GO:0030308]; neuron projection development [GO:0031175]; positive regulation of protein localization to actin cortical patch [GO:1904372]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein localization to actin cytoskeleton [GO:1903119]; protein localization to cell periphery [GO:1990778]; regulation of cell cycle [GO:0051726]; regulation of cell growth by extracellular stimulus [GO:0001560]; regulation of cell population proliferation [GO:0042127]; regulation of exit from mitosis [GO:0007096]; regulation of opioid receptor signaling pathway [GO:2000474]; regulation of protein phosphorylation [GO:0001932]; reproductive system development [GO:0061458]; response to amphetamine [GO:0001975]; response to immobilization stress [GO:0035902]; response to kainic acid [GO:1904373]; response to L-phenylalanine derivative [GO:1904386]; response to nicotine [GO:0035094]; response to prostaglandin E [GO:0034695]; response to steroid hormone [GO:0048545]; RNA splicing [GO:0008380]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoplasmic side of dendritic spine plasma membrane [GO:1990780]; dendrite [GO:0030425]; dendritic spine head [GO:0044327]; dendritic spine neck [GO:0044326]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein phosphatase type 1 complex [GO:0000164]; ruffle membrane [GO:0032587]	actin filament binding [GO:0051015]; D2 dopamine receptor binding [GO:0031749]; kinase binding [GO:0019900]; protein kinase activity [GO:0004672]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase inhibitor activity [GO:0004864]; transmembrane transporter binding [GO:0044325]	12163.37743465385	-0.0164578290763364	0.999890807934025	1
P62714	P62714	PP2AB_HUMAN	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16)	PPP2CB	apoptotic mitochondrial changes [GO:0008637]; mitotic cell cycle [GO:0000278]; negative regulation of gene expression [GO:0010629]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; peptidyl-serine dephosphorylation [GO:0070262]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of microtubule binding [GO:1904528]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein dephosphorylation [GO:0006470]; response to antibiotic [GO:0046677]; response to endoplasmic reticulum stress [GO:0034976]; response to hydrogen peroxide [GO:0042542]; response to lead ion [GO:0010288]	chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]; spindle pole [GO:0000922]	metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]; tau protein binding [GO:0048156]; transmembrane transporter binding [GO:0044325]	106174.3350880025	0.0466548195849237	0.755847635648174	1
P30153	P30153	2AAA_HUMAN	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha)	PPP2R1A	chromosome segregation [GO:0007059]; female meiotic nuclear division [GO:0007143]; intracellular signal transduction [GO:0035556]; meiotic sister chromatid cohesion, centromeric [GO:0051754]; meiotic spindle elongation [GO:0051232]; mitotic sister chromatid separation [GO:0051306]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; protein-containing complex assembly [GO:0065003]; regulation of cell differentiation [GO:0045595]; regulation of growth [GO:0040008]; regulation of meiotic cell cycle process involved in oocyte maturation [GO:1903538]; T cell homeostasis [GO:0043029]	chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]	protein antigen binding [GO:1990405]; protein heterodimerization activity [GO:0046982]; protein phosphatase regulator activity [GO:0019888]; protein serine/threonine phosphatase activity [GO:0004722]	65677.19597038535	-0.0756135148141161	0.954060415367725	1
P30154	P30154	2AAB_HUMAN	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A subunit A isoform PR65-beta) (PP2A subunit A isoform R1-beta)	PPP2R1B	apoptotic process involved in morphogenesis [GO:0060561]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]	protein phosphatase regulator activity [GO:0019888]	2560.812020027355	-0.0151483298358914	0.999999966825167	1
P63151	P63151	2ABA_HUMAN	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PP2A subunit B isoform B55-alpha) (PP2A subunit B isoform PR55-alpha) (PP2A subunit B isoform R2-alpha) (PP2A subunit B isoform alpha)	PPP2R2A	protein dephosphorylation [GO:0006470]; response to morphine [GO:0043278]	cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; protein phosphatase type 2A complex [GO:0000159]	protein phosphatase regulator activity [GO:0019888]	26419.21243142855	0.00635798001449817	0.999999999990444	1
Q66LE6	Q66LE6	2ABD_HUMAN	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform (PP2A subunit B isoform B55-delta) (PP2A subunit B isoform PR55-delta) (PP2A subunit B isoform R2-delta) (PP2A subunit B isoform delta)	PPP2R2D	cell division [GO:0051301]; exit from mitosis [GO:0010458]; mitotic cell cycle [GO:0000278]	cytosol [GO:0005829]; protein phosphatase type 2A complex [GO:0000159]	protein phosphatase regulator activity [GO:0019888]	6162.321721407355	-0.0478956063680226	0.997187039790955	1
Q15172	Q15172	2A5A_HUMAN	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha)	PPP2R5A	negative regulation of lipid kinase activity [GO:0090219]; negative regulation of protein localization to plasma membrane [GO:1903077]; positive regulation of protein dephosphorylation [GO:0035307]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]	centrosome [GO:0005813]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; M band [GO:0031430]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein phosphatase type 2A complex [GO:0000159]; Z disc [GO:0030018]	kinase binding [GO:0019900]; phosphoprotein phosphatase activity [GO:0004721]; protein phosphatase activator activity [GO:0072542]; protein phosphatase regulator activity [GO:0019888]	7910.5604654758645	0.0181445539993404	0.9584199702554	1
Q13362	Q13362	2A5G_HUMAN	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-gamma) (PP2A B subunit isoform PR61-gamma) (PP2A B subunit isoform R5-gamma) (Renal carcinoma antigen NY-REN-29)	PPP2R5C	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of cell population proliferation [GO:0008285]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; signal transduction [GO:0007165]	chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]	protein phosphatase activator activity [GO:0072542]; protein phosphatase regulator activity [GO:0019888]	7953.86099513404	0.0952892665543931	0.952551979746558	1
Q16537	Q16537	2A5E_HUMAN	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A B subunit isoform B'-epsilon) (PP2A B subunit isoform B56-epsilon) (PP2A B subunit isoform PR61-epsilon) (PP2A B subunit isoform R5-epsilon)	PPP2R5E	signal transduction [GO:0007165]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]	protein phosphatase activator activity [GO:0072542]; protein phosphatase regulator activity [GO:0019888]	15905.8194546297	0.114197356781725	0.802294432499239	1
P48454	P48454	PP2BC_HUMAN	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin, testis-specific catalytic subunit) (Calmodulin-dependent calcineurin A subunit gamma isoform)	PPP3CC	calcineurin-mediated signaling [GO:0097720]; calcineurin-NFAT signaling cascade [GO:0033173]; negative regulation of calcium ion import across plasma membrane [GO:1905949]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; protein dephosphorylation [GO:0006470]	calcineurin complex [GO:0005955]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; presynapse [GO:0098793]; protein serine/threonine phosphatase complex [GO:0008287]	calcium-dependent protein serine/threonine phosphatase activity [GO:0004723]; calmodulin binding [GO:0005516]; calmodulin-dependent protein phosphatase activity [GO:0033192]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]	9535.211804061355	-0.358130524353245	0.856959544512954	1
Q8TF05	Q8TF05	PP4R1_HUMAN	Serine/threonine-protein phosphatase 4 regulatory subunit 1	PPP4R1	protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]	cytoplasm [GO:0005737]; protein phosphatase 4 complex [GO:0030289]	protein phosphatase regulator activity [GO:0019888]	10245.144942034276	0.0742660844848293	0.998129739293116	1
Q6NUP7	Q6NUP7	PP4R4_HUMAN	Serine/threonine-protein phosphatase 4 regulatory subunit 4	PPP4R4	blastocyst hatching [GO:0001835]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; regulation of protein serine/threonine phosphatase activity [GO:0080163]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein serine/threonine phosphatase complex [GO:0008287]	protein phosphatase regulator activity [GO:0019888]	5237.48394876625	-0.0182098074564845	0.983401321155458	1
O00743	O00743	PPP6_HUMAN	Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed]	PPP6C	COPII vesicle coating [GO:0048208]; G1/S transition of mitotic cell cycle [GO:0000082]; innate immune response [GO:0045087]; negative regulation of cGAS/STING signaling pathway [GO:0160049]; protein dephosphorylation [GO:0006470]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722]	20943.42943600875	0.066751919612184	0.740414407188922	1
Q9UPN7	Q9UPN7	PP6R1_HUMAN	Serine/threonine-protein phosphatase 6 regulatory subunit 1 (SAPS domain family member 1)	PPP6R1	regulation of phosphoprotein phosphatase activity [GO:0043666]	cytosol [GO:0005829]; nucleus [GO:0005634]	protein phosphatase binding [GO:0019903]; protein phosphatase regulator activity [GO:0019888]; small GTPase binding [GO:0031267]	9387.67906535389	0.130656638628041	0.856361414074568	1
O75170	O75170	PP6R2_HUMAN	Serine/threonine-protein phosphatase 6 regulatory subunit 2 (SAPS domain family member 2)	PPP6R2		cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleus [GO:0005634]	protein phosphatase binding [GO:0019903]; protein phosphatase regulator activity [GO:0019888]	6593.198220228989	-0.12208598216307	0.836667288452521	1
Q5H9R7	Q5H9R7	PP6R3_HUMAN	Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL)	PPP6R3	regulation of phosphoprotein phosphatase activity [GO:0043666]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	protein phosphatase binding [GO:0019903]; protein phosphatase regulator activity [GO:0019888]	8649.53845572128	0.0361159510793942	0.996268734149607	1
P50897	P50897	PPT1_HUMAN	Palmitoyl-protein thioesterase 1 (PPT-1) (EC 3.1.2.22) (Palmitoyl-protein hydrolase 1)	PPT1	adult locomotory behavior [GO:0008344]; associative learning [GO:0008306]; brain development [GO:0007420]; fatty-acyl-CoA biosynthetic process [GO:0046949]; grooming behavior [GO:0007625]; lipid catabolic process [GO:0016042]; lysosomal lumen acidification [GO:0007042]; membrane raft organization [GO:0031579]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of neuron apoptotic process [GO:0043524]; nervous system development [GO:0007399]; neuron development [GO:0048666]; neurotransmitter secretion [GO:0007269]; pinocytosis [GO:0006907]; positive regulation of pinocytosis [GO:0048549]; positive regulation of receptor-mediated endocytosis [GO:0048260]; protein catabolic process [GO:0030163]; protein depalmitoylation [GO:0002084]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; regulation of synapse structure or activity [GO:0050803]; response to stimulus [GO:0050896]; sphingolipid catabolic process [GO:0030149]; visual perception [GO:0007601]	axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; synaptic vesicle [GO:0008021]	long-chain fatty acyl-CoA hydrolase activity [GO:0052816]; lysophosphatidic acid binding [GO:0035727]; palmitoyl-(protein) hydrolase activity [GO:0008474]; sulfatide binding [GO:0120146]	21504.5561172104	0.0375487558650777	0.9822571156769	1
Q92733	Q92733	PRCC_HUMAN	Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein)	PRCC	cell cycle [GO:0007049]; regulation of cell cycle [GO:0051726]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]		7356.70482261564	0.101549206082743	0.819050140990474	1
Q13162	Q13162	PRDX4_HUMAN	Peroxiredoxin-4 (EC 1.11.1.24) (Antioxidant enzyme AOE372) (AOE37-2) (Peroxiredoxin IV) (Prx-IV) (Thioredoxin peroxidase AO372) (Thioredoxin-dependent peroxide reductase A0372) (Thioredoxin-dependent peroxiredoxin 4)	PRDX4	cell redox homeostasis [GO:0045454]; cellular response to stress [GO:0033554]; extracellular matrix organization [GO:0030198]; hydrogen peroxide catabolic process [GO:0042744]; I-kappaB phosphorylation [GO:0007252]; male gonad development [GO:0008584]; negative regulation of male germ cell proliferation [GO:2000255]; protein maturation by protein folding [GO:0022417]; response to oxidative stress [GO:0006979]; spermatogenesis [GO:0007283]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]	identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; molecular sequestering activity [GO:0140313]; thioredoxin peroxidase activity [GO:0008379]	316655.421189606	0.0121186479958132	0.999999988206215	1
P30041	P30041	PRDX6_HUMAN	Peroxiredoxin-6 (EC 1.11.1.27) (1-Cys peroxiredoxin) (1-Cys PRX) (24 kDa protein) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.4) (Antioxidant protein 2) (Glutathione-dependent peroxiredoxin) (Liver 2D page spot 40) (Lysophosphatidylcholine acyltransferase 5) (LPC acyltransferase 5) (LPCAT-5) (Lyso-PC acyltransferase 5) (EC 2.3.1.23) (Non-selenium glutathione peroxidase) (NSGPx) (Red blood cells page spot 12)	PRDX6	cell redox homeostasis [GO:0045454]; cellular oxidant detoxification [GO:0098869]; glycerophospholipid catabolic process [GO:0046475]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; response to oxidative stress [GO:0006979]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; cadherin binding [GO:0045296]; calcium-independent phospholipase A2 activity [GO:0047499]; glutathione peroxidase activity [GO:0004602]; identical protein binding [GO:0042802]; peroxiredoxin activity [GO:0051920]; phospholipase A2 activity [GO:0004623]; ubiquitin protein ligase binding [GO:0031625]	342404.20542093646	-0.0984599099987877	0.961858590378692	1
Q13131	Q13131	AAPK1_HUMAN	5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)	PRKAA1	autophagy [GO:0006914]; bile acid and bile salt transport [GO:0015721]; bile acid signaling pathway [GO:0038183]; CAMKK-AMPK signaling cascade [GO:0061762]; cellular response to calcium ion [GO:0071277]; cellular response to ethanol [GO:0071361]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to nutrient levels [GO:0031669]; cellular response to organonitrogen compound [GO:0071417]; cellular response to oxidative stress [GO:0034599]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to xenobiotic stimulus [GO:0071466]; cholesterol biosynthetic process [GO:0006695]; cold acclimation [GO:0009631]; energy homeostasis [GO:0097009]; fatty acid biosynthetic process [GO:0006633]; fatty acid homeostasis [GO:0055089]; fatty acid oxidation [GO:0019395]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; lipid biosynthetic process [GO:0008610]; lipid droplet disassembly [GO:1905691]; motor behavior [GO:0061744]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of glucosylceramide biosynthetic process [GO:0046318]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of tubulin deacetylation [GO:1904428]; neuron cellular homeostasis [GO:0070050]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of autophagy [GO:0010508]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of glycolytic process [GO:0045821]; positive regulation of mitochondrial transcription [GO:1903109]; positive regulation of peptidyl-lysine acetylation [GO:2000758]; positive regulation of protein localization [GO:1903829]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of skeletal muscle tissue development [GO:0048643]; protein localization to lipid droplet [GO:1990044]; protein phosphorylation [GO:0006468]; regulation of bile acid secretion [GO:0120188]; regulation of circadian rhythm [GO:0042752]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of peptidyl-serine phosphorylation [GO:0033135]; regulation of stress granule assembly [GO:0062028]; regulation of vesicle-mediated transport [GO:0060627]; response to activity [GO:0014823]; response to caffeine [GO:0031000]; response to estrogen [GO:0043627]; response to gamma radiation [GO:0010332]; response to hypoxia [GO:0001666]; response to UV [GO:0009411]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]	[acetyl-CoA carboxylase] kinase activity [GO:0050405]; [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity [GO:0047322]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; chromatin binding [GO:0003682]; histone H2BS36 kinase activity [GO:0140823]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]	18109.978378182597	-0.16086777987668	0.852224651961158	1

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