Selected Cell
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stat_data__min_2_Peptides
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| O00116 | O00116 | ADAS_HUMAN | Alkyldihydroxyacetonephosphate synthase, peroxisomal (Alkyl-DHAP synthase) (EC 2.5.1.26) (Aging-associated gene 5 protein) (Alkylglycerone-phosphate synthase) | AGPS | ether lipid biosynthetic process [GO:0008611]; lipid biosynthetic process [GO:0008610] | cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] | alkylglycerone-phosphate synthase activity [GO:0008609]; FAD binding [GO:0071949] | 17027.6657774758 | -0.302939439877229 | 1.1559214217209E-9 | 3.27472538773532E-8 |
| Q07812 | Q07812 | BAX_HUMAN | Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4) | BAX | activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; apoptotic mitochondrial changes [GO:0008637]; apoptotic process [GO:0006915]; apoptotic process involved in blood vessel morphogenesis [GO:1902262]; apoptotic process involved in embryonic digit morphogenesis [GO:1902263]; apoptotic process involved in mammary gland involution [GO:0060057]; apoptotic signaling pathway [GO:0097190]; B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; B cell homeostatic proliferation [GO:0002358]; B cell negative selection [GO:0002352]; B cell receptor apoptotic signaling pathway [GO:1990117]; blood vessel remodeling [GO:0001974]; calcium ion transport into cytosol [GO:0060402]; cellular response to unfolded protein [GO:0034620]; cellular response to UV [GO:0034644]; cellular response to virus [GO:0098586]; cerebral cortex development [GO:0021987]; development of secondary sexual characteristics [GO:0045136]; ectopic germ cell programmed cell death [GO:0035234]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; epithelial cell apoptotic process [GO:1904019]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; fertilization [GO:0009566]; germ cell development [GO:0007281]; glycosphingolipid metabolic process [GO:0006687]; homeostasis of number of cells within a tissue [GO:0048873]; hypothalamus development [GO:0021854]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; kidney development [GO:0001822]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial fusion [GO:0008053]; motor neuron apoptotic process [GO:0097049]; myeloid cell homeostasis [GO:0002262]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of protein binding [GO:0032091]; neuron migration [GO:0001764]; odontogenesis of dentin-containing tooth [GO:0042475]; ovarian follicle development [GO:0001541]; positive regulation of apoptotic DNA fragmentation [GO:1902512]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of B cell apoptotic process [GO:0002904]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of developmental pigmentation [GO:0048087]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902110]; positive regulation of motor neuron apoptotic process [GO:2000673]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of reproductive process [GO:2000243]; post-embryonic camera-type eye morphogenesis [GO:0048597]; protein insertion into mitochondrial membrane [GO:0051204]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of mammary gland epithelial cell proliferation [GO:0033599]; regulation of mitochondrial membrane permeability involved in programmed necrotic cell death [GO:1902445]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of nitrogen utilization [GO:0006808]; release of cytochrome c from mitochondria [GO:0001836]; release of matrix enzymes from mitochondria [GO:0032976]; release of sequestered calcium ion into cytosol [GO:0051209]; response to axon injury [GO:0048678]; response to gamma radiation [GO:0010332]; response to salt stress [GO:0009651]; response to toxic substance [GO:0009636]; retina development in camera-type eye [GO:0060041]; retinal cell programmed cell death [GO:0046666]; Sertoli cell proliferation [GO:0060011]; spermatid differentiation [GO:0048515]; supramolecular fiber organization [GO:0097435]; T cell homeostatic proliferation [GO:0001777]; thymocyte apoptotic process [GO:0070242]; vagina development [GO:0060068] | BAK complex [GO:0097145]; BAX complex [GO:0097144]; Bcl-2 family protein complex [GO:0097136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; pore complex [GO:0046930] | BH3 domain binding [GO:0051434]; channel activity [GO:0015267]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] | 48327.883937819 | -1.10525738402171 | 1.20184567594068E-9 | 3.38788935317407E-8 |
| P27824 | P27824 | CALX_HUMAN | Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90) | CANX | clathrin-dependent endocytosis [GO:0072583]; ERAD pathway [GO:0036503]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; protein secretion [GO:0009306]; synaptic vesicle endocytosis [GO:0048488]; viral protein processing [GO:0019082] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; extracellular exosome [GO:0070062]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrial membrane [GO:0031966]; nuclear membrane [GO:0031965]; presynapse [GO:0098793] | calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082] | 187842.0844242035 | 0.274413555670521 | 1.23866474740534E-9 | 3.47439329643499E-8 |
| P0DMV8;P0DMV9 | P0DMV8 | HS71A_HUMAN | Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A) | HSPA1A | ATP metabolic process [GO:0046034]; cellular heat acclimation [GO:0070370]; cellular response to heat [GO:0034605]; cellular response to oxidative stress [GO:0034599]; cellular response to steroid hormone stimulus [GO:0071383]; cellular response to unfolded protein [GO:0034620]; chaperone cofactor-dependent protein refolding [GO:0051085]; chaperone-mediated protein complex assembly [GO:0051131]; lysosomal transport [GO:0007041]; mRNA catabolic process [GO:0006402]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of inclusion body assembly [GO:0090084]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of endoribonuclease activity [GO:1902380]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of microtubule nucleation [GO:0090063]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070434]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of RNA splicing [GO:0033120]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; protein refolding [GO:0042026]; protein stabilization [GO:0050821]; regulation of mitotic spindle assembly [GO:1901673]; regulation of protein ubiquitination [GO:0031396]; response to unfolded protein [GO:0006986] | aggresome [GO:0016235]; blood microparticle [GO:0072562]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; inclusion body [GO:0016234]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; vesicle [GO:0031982] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein disaggregase activity [GO:0140545]; ATP-dependent protein folding chaperone [GO:0140662]; C3HC4-type RING finger domain binding [GO:0055131]; cadherin binding [GO:0045296]; death receptor agonist activity [GO:0038177]; denatured protein binding [GO:0031249]; disordered domain specific binding [GO:0097718]; enzyme binding [GO:0019899]; G protein-coupled receptor binding [GO:0001664]; heat shock protein binding [GO:0031072]; histone deacetylase binding [GO:0042826]; misfolded protein binding [GO:0051787]; protein folding chaperone [GO:0044183]; receptor ligand activity [GO:0048018]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; virus receptor activity [GO:0001618] | 242857.886150241 | 0.216206056944564 | 1.26599132098661E-9 | 3.53355015995572E-8 |
| O60551 | O60551 | NMT2_HUMAN | Glycylpeptide N-tetradecanoyltransferase 2 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 2) (NMT 2) (Peptide N-myristoyltransferase 2) (Protein-lysine myristoyltransferase NMT2) (EC 2.3.1.-) (Type II N-myristoyltransferase) | NMT2 | intracellular transport of virus [GO:0075733]; N-terminal peptidyl-glycine N-myristoylation [GO:0018008]; regulation of rhodopsin mediated signaling pathway [GO:0022400] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; host cell [GO:0043657]; plasma membrane [GO:0005886] | glycylpeptide N-tetradecanoyltransferase activity [GO:0004379]; peptidyl-lysine N6-myristoyltransferase activity [GO:0018030] | 17852.237111513852 | 0.644942188657427 | 1.43046901053641E-9 | 3.97305755573496E-8 |
| Q6UY14 | Q6UY14 | ATL4_HUMAN | ADAMTS-like protein 4 (ADAMTSL-4) (Thrombospondin repeat-containing protein 1) | ADAMTSL4 | apoptotic process [GO:0006915]; epithelial cell development [GO:0002064]; extracellular matrix organization [GO:0030198]; pigment cell development [GO:0070285]; positive regulation of apoptotic process [GO:0043065]; proteolysis [GO:0006508] | collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; interstitial matrix [GO:0005614] | identical protein binding [GO:0042802]; metalloendopeptidase activity [GO:0004222]; protease binding [GO:0002020] | 20323.41941397355 | 0.571652987358246 | 1.53261428505648E-9 | 4.23599636055124E-8 |
| Q9UNF1 | Q9UNF1 | MAGD2_HUMAN | Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) | MAGED2 | female pregnancy [GO:0007565]; negative regulation of transcription by RNA polymerase II [GO:0000122]; renal sodium ion absorption [GO:0070294] | cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093] | 40740.53796088165 | 0.468944429476939 | 1.58976628416834E-9 | 4.37262901266885E-8 | |
| P09211 | P09211 | GSTP1_HUMAN | Glutathione S-transferase P (EC 2.5.1.18) (GST class-pi) (GSTP1-1) | GSTP1 | cellular response to lipopolysaccharide [GO:0071222]; central nervous system development [GO:0007417]; common myeloid progenitor cell proliferation [GO:0035726]; glutathione derivative biosynthetic process [GO:1901687]; glutathione metabolic process [GO:0006749]; hepoxilin biosynthetic process [GO:0051122]; linoleic acid metabolic process [GO:0043651]; negative regulation of acute inflammatory response [GO:0002674]; negative regulation of apoptotic process [GO:0043066]; negative regulation of biosynthetic process [GO:0009890]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of leukocyte proliferation [GO:0070664]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; nitric oxide storage [GO:0035732]; positive regulation of superoxide anion generation [GO:0032930]; prostaglandin metabolic process [GO:0006693]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of stress-activated MAPK cascade [GO:0032872]; response to reactive oxygen species [GO:0000302]; xenobiotic metabolic process [GO:0006805] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; TRAF2-GSTP1 complex [GO:0097057]; vesicle [GO:0031982] | dinitrosyl-iron complex binding [GO:0035731]; fatty acid binding [GO:0005504]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; JUN kinase binding [GO:0008432]; kinase regulator activity [GO:0019207]; nitric oxide binding [GO:0070026]; S-nitrosoglutathione binding [GO:0035730] | 487152.74352022 | -0.708422101230298 | 1.60570109707188E-9 | 4.39512194010109E-8 |
| Q9UHI8 | Q9UHI8 | ATS1_HUMAN | A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAM-TS 1) (ADAM-TS1) (ADAMTS-1) (EC 3.4.24.-) (METH-1) | ADAMTS1 | extracellular matrix organization [GO:0030198]; heart trabecula formation [GO:0060347]; integrin-mediated signaling pathway [GO:0007229]; kidney development [GO:0001822]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell population proliferation [GO:0008285]; ovulation from ovarian follicle [GO:0001542]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; proteolysis [GO:0006508] | basement membrane [GO:0005604]; cytoplasmic vesicle [GO:0031410]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576] | heparin binding [GO:0008201]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] | 48984.419879772046 | 0.403202745430199 | 2.09786372197137E-9 | 5.6602361184237E-8 |
| Q8NFJ5 | Q8NFJ5 | RAI3_HUMAN | Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1) | GPRC5A | negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; signal transduction [GO:0007165] | cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; vesicle [GO:0031982] | cadherin binding [GO:0045296]; G protein-coupled receptor activity [GO:0004930]; protein kinase activator activity [GO:0030295] | 21386.020394972053 | 1.91991636952018 | 2.08602455003733E-9 | 5.6602361184237E-8 |
| Q9Y266 | Q9Y266 | NUDC_HUMAN | Nuclear migration protein nudC (Nuclear distribution protein C homolog) | NUDC | cell division [GO:0051301]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle organization [GO:0007052]; nuclear migration [GO:0007097]; protein folding [GO:0006457]; response to peptide hormone [GO:0043434] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; spindle [GO:0005819] | cadherin binding [GO:0045296]; unfolded protein binding [GO:0051082] | 108899.3021566605 | 0.431700959315005 | 2.09761847914107E-9 | 5.6602361184237E-8 |
| Q9UNF0 | Q9UNF0 | PACN2_HUMAN | Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII) | PACSIN2 | actin cytoskeleton organization [GO:0030036]; caveola assembly [GO:0070836]; caveolin-mediated endocytosis [GO:0072584]; cell projection morphogenesis [GO:0048858]; cytoskeleton organization [GO:0007010]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of endocytosis [GO:0045806]; plasma membrane tubulation [GO:0097320]; protein localization to endosome [GO:0036010]; regulation of endocytosis [GO:0030100] | caveola [GO:0005901]; cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; ruffle membrane [GO:0032587] | cadherin binding [GO:0045296]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; phosphatidic acid binding [GO:0070300]; phospholipid binding [GO:0005543] | 48678.9750684377 | 0.350504081746069 | 2.20005702941604E-9 | 5.90783086666885E-8 |
| Q9BRK3 | Q9BRK3 | MXRA8_HUMAN | Matrix remodeling-associated protein 8 (Limitrin) | MXRA8 | cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; establishment of glial blood-brain barrier [GO:0060857] | bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; ciliary membrane [GO:0060170]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] | 16105.56818601435 | -1.40562372600934 | 2.26657666947391E-9 | 6.05774689115056E-8 | |
| O15498 | O15498 | YKT6_HUMAN | Synaptobrevin homolog YKT6 (EC 2.3.1.-) | YKT6 | endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle docking involved in exocytosis [GO:0006904]; vesicle targeting [GO:0006903] | apical dendrite [GO:0097440]; basal dendrite [GO:0097441]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; SNARE complex [GO:0031201]; transport vesicle [GO:0030133] | cadherin binding [GO:0045296]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; SNAP receptor activity [GO:0005484] | 93087.45725348554 | -0.936554621490439 | 2.45671347751553E-9 | 6.53508852751315E-8 |
| O00303 | O00303 | EIF3F_HUMAN | Eukaryotic translation initiation factor 3 subunit F (eIF3f) (Deubiquitinating enzyme eIF3f) (EC 3.4.19.12) (Eukaryotic translation initiation factor 3 subunit 5) (eIF-3-epsilon) (eIF3 p47) | EIF3F | formation of cytoplasmic translation initiation complex [GO:0001732]; IRES-dependent viral translational initiation [GO:0075522]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; translational initiation [GO:0006413] | cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; membrane [GO:0016020]; synapse [GO:0045202] | cysteine-type deubiquitinase activity [GO:0004843]; identical protein binding [GO:0042802]; metal-dependent deubiquitinase activity [GO:0140492]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369] | 22258.5257052661 | -1.09796401084883 | 2.72537714962219E-9 | 7.2158817428782E-8 |
| Q9UH65 | Q9UH65 | SWP70_HUMAN | Switch-associated protein 70 (SWAP-70) | SWAP70 | actin filament bundle assembly [GO:0051017]; isotype switching [GO:0045190]; negative regulation of actin filament depolymerization [GO:0030835]; negative regulation of cell-cell adhesion mediated by integrin [GO:0033633]; negative regulation of peptidyl-serine dephosphorylation [GO:1902309]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of mast cell chemotaxis [GO:0060754]; regulation of protein localization [GO:0032880]; regulation of small GTPase mediated signal transduction [GO:0051056] | actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; DNA binding [GO:0003677]; guanyl-nucleotide exchange factor activity [GO:0005085] | 35403.9114524202 | -0.333789578909062 | 2.74415064070492E-9 | 7.23179420010888E-8 |
| Q9Y2Q3 | Q9Y2Q3 | GSTK1_HUMAN | Glutathione S-transferase kappa 1 (EC 2.5.1.18) (GST 13-13) (GST class-kappa) (GSTK1-1) (hGSTK1) (Glutathione S-transferase subunit 13) | GSTK1 | epithelial cell differentiation [GO:0030855]; glutathione metabolic process [GO:0006749] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] | glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364] | 14633.641832793499 | -1.38747926434968 | 2.93601300563814E-9 | 7.70159707867857E-8 |
| Q16401 | Q16401 | PSMD5_HUMAN | 26S proteasome non-ATPase regulatory subunit 5 (26S protease subunit S5 basic) (26S proteasome subunit S5B) | PSMD5 | proteasome regulatory particle assembly [GO:0070682] | cytosol [GO:0005829]; nucleoplasm [GO:0005654]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502] | 30748.737800102797 | -0.378350107561001 | 2.95779990530011E-9 | 7.72299274812461E-8 | |
| P35237 | P35237 | SPB6_HUMAN | Serpin B6 (Cytoplasmic antiproteinase) (CAP) (Peptidase inhibitor 6) (PI-6) (Placental thrombin inhibitor) | SERPINB6 | cellular response to osmotic stress [GO:0071470]; negative regulation of endopeptidase activity [GO:0010951]; sensory perception of sound [GO:0007605] | collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; serine protease inhibitor complex [GO:0097180]; tertiary granule membrane [GO:0070821] | protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867] | 167790.7940930085 | -0.292316146389903 | 3.03856982567594E-9 | 7.89749386801828E-8 |
| Q14393 | Q14393 | GAS6_HUMAN | Growth arrest-specific protein 6 (GAS-6) (AXL receptor tyrosine kinase ligand) | GAS6 | activation of protein kinase B activity [GO:0032148]; animal organ regeneration [GO:0031100]; apoptotic cell clearance [GO:0043277]; B cell chemotaxis [GO:0035754]; blood coagulation [GO:0007596]; calcium ion transmembrane transport [GO:0070588]; cell surface receptor signaling pathway [GO:0007166]; cell-substrate adhesion [GO:0031589]; cellular response to glucose stimulus [GO:0071333]; cellular response to growth factor stimulus [GO:0071363]; cellular response to interferon-alpha [GO:0035457]; cellular response to starvation [GO:0009267]; cellular response to vitamin K [GO:0071307]; cellular response to xenobiotic stimulus [GO:0071466]; dendritic cell differentiation [GO:0097028]; enzyme-linked receptor protein signaling pathway [GO:0007167]; extracellular matrix assembly [GO:0085029]; fibroblast apoptotic process [GO:0044346]; fusion of virus membrane with host plasma membrane [GO:0019064]; hematopoietic stem cell migration to bone marrow [GO:0097241]; myeloid cell apoptotic process [GO:0033028]; negative regulation of apoptotic process [GO:0043066]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of interleukin-1 production [GO:0032692]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of myeloid cell apoptotic process [GO:0033033]; negative regulation of oligodendrocyte apoptotic process [GO:1900142]; negative regulation of renal albumin absorption [GO:2000533]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; negative regulation of type II interferon production [GO:0032689]; neuron migration [GO:0001764]; phagocytosis [GO:0006909]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of glomerular filtration [GO:0003104]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of TOR signaling [GO:0032008]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; receptor-mediated virion attachment to host cell [GO:0046813]; signal transduction [GO:0007165]; symbiont entry into host cell [GO:0046718]; viral genome replication [GO:0019079] | cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; platelet alpha granule lumen [GO:0031093] | calcium ion binding [GO:0005509]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; phosphatidylserine binding [GO:0001786]; protein-macromolecule adaptor activity [GO:0030674]; receptor ligand activity [GO:0048018]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102] | 10023.45558227036 | -1.12166467345066 | 3.11445230545111E-9 | 8.057756512642E-8 |
| Q15043 | Q15043 | S39AE_HUMAN | Metal cation symporter ZIP14 (LIV-1 subfamily of ZIP zinc transporter 4) (LZT-Hs4) (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14) (ZIP-14) | SLC39A14 | cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; chondrocyte differentiation [GO:0002062]; gluconeogenesis [GO:0006094]; import across plasma membrane [GO:0098739]; inorganic cation transmembrane transport [GO:0098662]; insulin receptor signaling pathway [GO:0008286]; intracellular zinc ion homeostasis [GO:0006882]; iron import into cell [GO:0033212]; iron ion transmembrane transport [GO:0034755]; manganese ion homeostasis [GO:0055071]; manganese ion transmembrane transport [GO:0071421]; negative regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051344]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; regulation of hormone levels [GO:0010817]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577] | apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] | cadmium ion transmembrane transporter activity [GO:0015086]; ferrous iron transmembrane transporter activity [GO:0015093]; iron ion transmembrane transporter activity [GO:0005381]; manganese ion transmembrane transporter activity [GO:0005384]; monoatomic anion:monoatomic cation symporter activity [GO:0015296]; monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385] | 23972.30375307645 | 0.722292390207825 | 3.1554641953732E-9 | 8.12675460499299E-8 |
| Q92597 | Q92597 | NDRG1_HUMAN | Protein NDRG1 (Differentiation-related gene 1 protein) (DRG-1) (N-myc downstream-regulated gene 1 protein) (Nickel-specific induction protein Cap43) (Reducing agents and tunicamycin-responsive protein) (RTP) (Rit42) | NDRG1 | cellular response to hypoxia [GO:0071456]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; mast cell activation [GO:0045576]; negative regulation of cell population proliferation [GO:0008285]; peripheral nervous system myelin maintenance [GO:0032287]; response to metal ion [GO:0010038]; signal transduction [GO:0007165] | adherens junction [GO:0005912]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] | cadherin binding [GO:0045296]; gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017]; small GTPase binding [GO:0031267] | 216206.287849025 | 0.431793066617332 | 3.18044748854786E-9 | 8.15403414937202E-8 |
| P61106 | P61106 | RAB14_HUMAN | Ras-related protein Rab-14 (EC 3.6.5.2) | RAB14 | defense response to bacterium [GO:0042742]; endocytic recycling [GO:0032456]; fibroblast growth factor receptor signaling pathway [GO:0008543]; Golgi to endosome transport [GO:0006895]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; phagolysosome assembly involved in apoptotic cell clearance [GO:0090387]; phagosome maturation [GO:0090382]; regulation of embryonic development [GO:0045995]; regulation of protein localization [GO:0032880]; vesicle-mediated transport [GO:0016192] | cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nuclear outer membrane-endoplasmic reticulum membrane network [GO:0042175]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; rough endoplasmic reticulum [GO:0005791]; tertiary granule membrane [GO:0070821]; trans-Golgi network [GO:0005802]; trans-Golgi network transport vesicle [GO:0030140] | GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489] | 88539.00210519605 | -0.544294976291998 | 3.4060469682965E-9 | 8.69309104611169E-8 |
| P20340 | P20340 | RAB6A_HUMAN | Ras-related protein Rab-6A (Rab-6) | RAB6A | antigen processing and presentation [GO:0019882]; early endosome to Golgi transport [GO:0034498]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; localization [GO:0051179]; minus-end-directed organelle transport along microtubule [GO:0072385]; neuron projection development [GO:0031175]; peptidyl-cysteine methylation [GO:0018125]; protein localization to Golgi apparatus [GO:0034067]; protein localization to Golgi membrane [GO:1903292]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890] | acrosomal membrane [GO:0002080]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endosome to plasma membrane transport vesicle [GO:0070381]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588] | GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; protein domain specific binding [GO:0019904] | 43496.8951322148 | -1.56676995349659 | 3.47184850753277E-9 | 8.8212975980631E-8 |
| Q86SR1 | Q86SR1 | GLT10_HUMAN | Polypeptide N-acetylgalactosaminyltransferase 10 (EC 2.4.1.41) (Polypeptide GalNAc transferase 10) (GalNAc-T10) (pp-GaNTase 10) (Protein-UDP acetylgalactosaminyltransferase 10) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10) | GALNT10 | O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493] | Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] | carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] | 8548.802589916846 | -1.03782513674588 | 3.76469168424558E-9 | 9.52265316202477E-8 |
| P55287 | P55287 | CAD11_HUMAN | Cadherin-11 (OSF-4) (Osteoblast cadherin) (OB-cadherin) | CDH11 | adherens junction organization [GO:0034332]; aortic valve formation [GO:0003189]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; corticospinal tract morphogenesis [GO:0021957]; focal adhesion assembly [GO:0048041]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of cell migration [GO:0030336]; ossification [GO:0001503]; skeletal system development [GO:0001501] | adherens junction [GO:0005912]; catenin complex [GO:0016342]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685] | cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] | 36681.992978393 | 0.337777459323307 | 3.99806531265769E-9 | 1.00680169162304E-7 |
| O94905 | O94905 | ERLN2_HUMAN | Erlin-2 (Endoplasmic reticulum lipid raft-associated protein 2) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2) (SPFH domain-containing protein 2) | ERLIN2 | cholesterol metabolic process [GO:0008203]; ERAD pathway [GO:0036503]; negative regulation of cholesterol biosynthetic process [GO:0045541]; negative regulation of fatty acid biosynthetic process [GO:0045717]; regulation of cholesterol biosynthetic process [GO:0045540]; SREBP signaling pathway [GO:0032933] | cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] | cholesterol binding [GO:0015485]; ubiquitin protein ligase binding [GO:0031625] | 87913.54327283795 | 0.387832474127951 | 4.08078699679893E-9 | 1.02308580194083E-7 |
| P32322 | P32322 | P5CR1_HUMAN | Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2) | PYCR1 | cellular response to oxidative stress [GO:0034599]; L-proline biosynthetic process [GO:0055129]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; proline biosynthetic process [GO:0006561]; regulation of mitochondrial membrane potential [GO:0051881] | mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] | identical protein binding [GO:0042802]; pyrroline-5-carboxylate reductase activity [GO:0004735] | 102113.79052814649 | -0.948295655554613 | 4.19316085052059E-9 | 1.04662772594932E-7 |
| O95793 | O95793 | STAU1_HUMAN | Double-stranded RNA-binding protein Staufen homolog 1 | STAU1 | anterograde dendritic transport of messenger ribonucleoprotein complex [GO:0098964]; cellular response to oxidative stress [GO:0034599]; germ cell development [GO:0007281]; intracellular mRNA localization [GO:0008298]; lncRNA-mediated post-transcriptional gene silencing [GO:0000512]; modification of postsynaptic structure [GO:0099010]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of viral genome replication [GO:0045070]; protein localization to synapse [GO:0035418] | cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; messenger ribonucleoprotein complex [GO:1990124]; microtubule associated complex [GO:0005875]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791] | double-stranded RNA binding [GO:0003725]; mRNA binding [GO:0003729]; protein phosphatase 1 binding [GO:0008157]; RNA binding [GO:0003723] | 31640.68233486625 | 0.421587029006322 | 4.21754694440056E-9 | 1.04809741170937E-7 |
| P00533 | P00533 | EGFR_HUMAN | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | EGFR | activation of phospholipase C activity [GO:0007202]; astrocyte activation [GO:0048143]; cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion [GO:0098609]; cellular response to amino acid stimulus [GO:0071230]; cellular response to cadmium ion [GO:0071276]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to estradiol stimulus [GO:0071392]; cellular response to mechanical stimulus [GO:0071260]; cellular response to reactive oxygen species [GO:0034614]; cellular response to xenobiotic stimulus [GO:0071466]; cerebral cortex cell migration [GO:0021795]; circadian rhythm [GO:0007623]; digestive tract morphogenesis [GO:0048546]; diterpenoid metabolic process [GO:0016101]; embryonic placenta development [GO:0001892]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell proliferation [GO:0050673]; ERBB2-EGFR signaling pathway [GO:0038134]; eyelid development in camera-type eye [GO:0061029]; hair follicle development [GO:0001942]; hydrogen peroxide metabolic process [GO:0042743]; learning or memory [GO:0007611]; liver regeneration [GO:0097421]; lung development [GO:0030324]; midgut development [GO:0007494]; morphogenesis of an epithelial fold [GO:0060571]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiocyte differentiation [GO:1905208]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of protein catabolic process [GO:0042177]; neurogenesis [GO:0022008]; neuron projection morphogenesis [GO:0048812]; ossification [GO:0001503]; ovulation cycle [GO:0042698]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of bone resorption [GO:0045780]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of mucus secretion [GO:0070257]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phosphorylation [GO:0042327]; positive regulation of prolactin secretion [GO:1902722]; positive regulation of protein kinase C activity [GO:1900020]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vasoconstriction [GO:0045907]; protein autophosphorylation [GO:0046777]; protein insertion into membrane [GO:0051205]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of JNK cascade [GO:0046328]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; response to calcium ion [GO:0051592]; response to cobalamin [GO:0033590]; response to hydroxyisoflavone [GO:0033594]; response to UV-A [GO:0070141]; salivary gland morphogenesis [GO:0007435]; signal transduction [GO:0007165]; tongue development [GO:0043586]; translation [GO:0006412]; vasodilation [GO:0042311] | apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; intracellular vesicle [GO:0097708]; membrane [GO:0016020]; membrane raft [GO:0045121]; multivesicular body, internal vesicle lumen [GO:0097489]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]; ruffle membrane [GO:0032587]; Shc-EGFR complex [GO:0070435] | actin filament binding [GO:0051015]; ATP binding [GO:0005524]; ATPase binding [GO:0051117]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; chromatin binding [GO:0003682]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; epidermal growth factor binding [GO:0048408]; epidermal growth factor receptor activity [GO:0005006]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; kinase binding [GO:0019900]; MAP kinase kinase kinase activity [GO:0004709]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activator activity [GO:0030296]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane signaling receptor activity [GO:0004888]; ubiquitin protein ligase binding [GO:0031625]; virus receptor activity [GO:0001618] | 23310.874511474598 | 0.284298287612603 | 4.30719688948768E-9 | 1.06570207754747E-7 |
| P07737 | P07737 | PROF1_HUMAN | Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I) | PFN1 | actin cytoskeleton organization [GO:0030036]; modification of postsynaptic actin cytoskeleton [GO:0098885]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of actin filament bundle assembly [GO:0032232]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of stress fiber assembly [GO:0051497]; neural tube closure [GO:0001843]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of ruffle assembly [GO:1900029]; protein stabilization [GO:0050821]; regulation of actin filament polymerization [GO:0030833]; regulation of transcription by RNA polymerase II [GO:0006357]; synapse maturation [GO:0060074] | blood microparticle [GO:0072562]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleus [GO:0005634] | actin binding [GO:0003779]; actin monomer binding [GO:0003785]; adenyl-nucleotide exchange factor activity [GO:0000774]; cadherin binding [GO:0045296]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphotyrosine residue binding [GO:0001784]; proline-rich region binding [GO:0070064]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267] | 489657.022606419 | -0.771686048348429 | 4.5851539553547E-9 | 1.12954270917564E-7 |
| P61619 | P61619 | S61A1_HUMAN | Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1) | SEC61A1 | cotranslational protein targeting to membrane [GO:0006613]; endoplasmic reticulum organization [GO:0007029]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; post-translational protein targeting to membrane, translocation [GO:0031204]; pronephric nephron development [GO:0039019]; protein insertion into ER membrane [GO:0045048]; protein targeting to ER [GO:0045047]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616] | endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; Sec61 translocon complex [GO:0005784] | calcium channel activity [GO:0005262]; protein transmembrane transporter activity [GO:0008320]; ribosome binding [GO:0043022]; signal sequence binding [GO:0005048] | 37214.21728170045 | -0.923502114919741 | 4.86008723074827E-9 | 1.19208892854631E-7 |
| Q9H694 | Q9H694 | BICC1_HUMAN | Protein bicaudal C homolog 1 (Bic-C) | BICC1 | determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; kidney development [GO:0001822]; negative regulation of canonical Wnt signaling pathway [GO:0090090] | cytoplasm [GO:0005737] | RNA binding [GO:0003723] | 11245.0928560114 | -0.409619394448875 | 4.95979783540476E-9 | 1.21130235066394E-7 |
| P21964 | P21964 | COMT_HUMAN | Catechol O-methyltransferase (EC 2.1.1.6) | COMT | artery development [GO:0060840]; behavioral fear response [GO:0001662]; catecholamine catabolic process [GO:0042424]; cellular response to cocaine [GO:0071314]; cellular response to phosphate starvation [GO:0016036]; cerebellar cortex morphogenesis [GO:0021696]; cholesterol efflux [GO:0033344]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; developmental process [GO:0032502]; dopamine catabolic process [GO:0042420]; dopamine metabolic process [GO:0042417]; dopamine secretion [GO:0014046]; exploration behavior [GO:0035640]; gene expression [GO:0010467]; glomerulus development [GO:0032835]; glycogen metabolic process [GO:0005977]; habituation [GO:0046959]; mastication [GO:0071626]; memory [GO:0007613]; methylation [GO:0032259]; multicellular organism growth [GO:0035264]; norepinephrine metabolic process [GO:0042415]; norepinephrine secretion [GO:0048243]; prostaglandin metabolic process [GO:0006693]; renal albumin absorption [GO:0097018]; renal filtration [GO:0097205]; renal sodium excretion [GO:0035812]; renin secretion into blood stream [GO:0002001]; response to amphetamine [GO:0001975]; response to angiotensin [GO:1990776]; response to corticosterone [GO:0051412]; response to cytokine [GO:0034097]; response to dopamine [GO:1903350]; response to food [GO:0032094]; response to hypoxia [GO:0001666]; response to inorganic substance [GO:0010035]; response to oxidative stress [GO:0006979]; response to salt [GO:1902074]; response to toxic substance [GO:0009636]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; startle response [GO:0001964]; synaptic transmission, dopaminergic [GO:0001963]; visual learning [GO:0008542] | axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202] | catechol O-methyltransferase activity [GO:0016206]; L-dopa O-methyltransferase activity [GO:0102084]; magnesium ion binding [GO:0000287]; methyltransferase activity [GO:0008168]; O-methyltransferase activity [GO:0008171]; orcinol O-methyltransferase activity [GO:0102938] | 71054.4058528709 | -0.829807339660779 | 5.1340387507519E-9 | 1.24847483097684E-7 |
| Q9Y696 | Q9Y696 | CLIC4_HUMAN | Chloride intracellular channel protein 4 (Intracellular chloride ion channel protein p64H1) | CLIC4 | angiogenesis [GO:0001525]; branching morphogenesis of an epithelial tube [GO:0048754]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; chloride transport [GO:0006821]; endothelial cell morphogenesis [GO:0001886]; establishment or maintenance of apical/basal cell polarity [GO:0035088]; fertilization [GO:0009566]; keratinocyte differentiation [GO:0030216]; multicellular organism growth [GO:0035264]; negative regulation of cell migration [GO:0030336]; regulation of cytoskeleton organization [GO:0051493]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; vacuolar acidification [GO:0007035] | actin cytoskeleton [GO:0015629]; apical part of cell [GO:0045177]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; centrosome [GO:0005813]; chloride channel complex [GO:0034707]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; microvillus [GO:0005902]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] | chloride channel activity [GO:0005254] | 254335.98109156347 | 0.408492501854551 | 5.34304620748769E-9 | 1.29374785519766E-7 |
| Q9H788 | Q9H788 | SH24A_HUMAN | SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38) | SH2D4A | cytoplasm [GO:0005737]; cytosol [GO:0005829] | phosphatase binding [GO:0019902] | 24201.0009753779 | 0.510842881712437 | 5.42946040462229E-9 | 1.30907755968468E-7 | |
| Q9Y4K0 | Q9Y4K0 | LOXL2_HUMAN | Lysyl oxidase homolog 2 (EC 1.4.3.13) (Lysyl oxidase-like protein 2) (Lysyl oxidase-related protein 2) (Lysyl oxidase-related protein WS9-14) | LOXL2 | collagen fibril organization [GO:0030199]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; epithelial to mesenchymal transition [GO:0001837]; heterochromatin organization [GO:0070828]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-lysine oxidation [GO:0018057]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; protein modification process [GO:0036211]; response to copper ion [GO:0046688]; response to hypoxia [GO:0001666]; sprouting angiogenesis [GO:0002040] | basement membrane [GO:0005604]; chromatin [GO:0000785]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; oligosaccharide binding [GO:0070492]; protein-lysine 6-oxidase activity [GO:0004720] | 63134.1036251926 | -0.432941494239084 | 6.45005964599397E-9 | 1.54856093026279E-7 |
| Q8NBQ5 | Q8NBQ5 | DHB11_HUMAN | Estradiol 17-beta-dehydrogenase 11 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17bHSD11) (17betaHSD11) (17-beta-hydroxysteroid dehydrogenase XI) (17-beta-HSD XI) (17betaHSDXI) (Cutaneous T-cell lymphoma-associated antigen HD-CL-03) (CTCL-associated antigen HD-CL-03) (Dehydrogenase/reductase SDR family member 8) (Retinal short-chain dehydrogenase/reductase 2) (retSDR2) (Short chain dehydrogenase/reductase family 16C member 2) | HSD17B11 | androgen catabolic process [GO:0006710]; estrogen biosynthetic process [GO:0006703] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811] | estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; steroid dehydrogenase activity [GO:0016229] | 7813.624412201691 | -1.62594184175444 | 6.49453381957203E-9 | 1.55265943551456E-7 |
| P60709 | P60709 | ACTB_HUMAN | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | ACTB | adherens junction assembly [GO:0034333]; apical protein localization [GO:0045176]; axonogenesis [GO:0007409]; cell motility [GO:0048870]; cellular response to cytochalasin B [GO:0072749]; chromatin remodeling [GO:0006338]; establishment or maintenance of cell polarity [GO:0007163]; maintenance of blood-brain barrier [GO:0035633]; morphogenesis of a polarized epithelium [GO:0001738]; negative regulation of cell differentiation [GO:0045596]; negative regulation of protein binding [GO:0032091]; platelet aggregation [GO:0070527]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of norepinephrine uptake [GO:0051623]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; postsynaptic actin cytoskeleton organization [GO:0098974]; protein localization to adherens junction [GO:0071896]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of double-strand break repair [GO:2000779]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of norepinephrine uptake [GO:0051621]; regulation of nucleotide-excision repair [GO:2000819]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of synaptic vesicle endocytosis [GO:1900242]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transepithelial transport [GO:0150111]; regulation of transmembrane transporter activity [GO:0022898]; substantia nigra development [GO:0021762] | actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; adherens junction [GO:0005912]; apical junction complex [GO:0043296]; axon [GO:0030424]; bBAF complex [GO:0140092]; blood microparticle [GO:0072562]; brahma complex [GO:0035060]; brush border [GO:0005903]; calyx of Held [GO:0044305]; cell-cell junction [GO:0005911]; chromatin [GO:0000785]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dense body [GO:0097433]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; GBAF complex [GO:0140288]; glutamatergic synapse [GO:0098978]; kinetochore [GO:0000776]; lamellipodium [GO:0030027]; membrane [GO:0016020]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic actin cytoskeleton [GO:0098871]; presynapse [GO:0098793]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; RSC-type complex [GO:0016586]; Schaffer collateral - CA1 synapse [GO:0098685]; SWI/SNF complex [GO:0016514]; synapse [GO:0045202]; tight junction [GO:0070160]; vesicle [GO:0031982] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; nitric-oxide synthase binding [GO:0050998]; protein kinase binding [GO:0019901]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973]; Tat protein binding [GO:0030957]; tau protein binding [GO:0048156] | 1380306.787576235 | -0.266658818872035 | 7.06844938086209E-9 | 1.67572527999852E-7 |
| O00159 | O00159 | MYO1C_HUMAN | Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb) | MYO1C | actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; cellular response to type II interferon [GO:0071346]; chromatin remodeling [GO:0006338]; endocytosis [GO:0006897]; positive regulation of cell migration [GO:0030335]; positive regulation of cellular response to insulin stimulus [GO:1900078]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; protein targeting to membrane [GO:0006612]; regulation of bicellular tight junction assembly [GO:2000810]; vascular endothelial growth factor signaling pathway [GO:0038084]; vesicle transport along actin filament [GO:0030050] | actin cytoskeleton [GO:0015629]; B-WICH complex [GO:0110016]; basal plasma membrane [GO:0009925]; brush border [GO:0005903]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filamentous actin [GO:0031941]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; membrane raft [GO:0045121]; microvillus [GO:0005902]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; stereocilium membrane [GO:0060171]; unconventional myosin complex [GO:0016461] | actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267] | 55349.75662093515 | -0.298710336923748 | 7.06227008921395E-9 | 1.67572527999852E-7 |
| P98082 | P98082 | DAB2_HUMAN | Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) | DAB2 | apoptotic process [GO:0006915]; cellular response to epidermal growth factor stimulus [GO:0071364]; clathrin coat assembly [GO:0048268]; leading edge cell differentiation [GO:0035026]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein binding [GO:0032091]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of aldosterone biosynthetic process [GO:0032349]; positive regulation of aldosterone secretion [GO:2000860]; positive regulation of cell migration [GO:0030335]; positive regulation of clathrin-dependent endocytosis [GO:2000370]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of endocytosis [GO:0045807]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; response to salt [GO:1902074]; response to steroid hormone [GO:0048545]; transforming growth factor beta receptor signaling pathway [GO:0007179]; Wnt signaling pathway [GO:0016055] | clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] | cargo receptor activity [GO:0038024]; clathrin adaptor activity [GO:0035615]; low-density lipoprotein particle receptor binding [GO:0050750]; SMAD binding [GO:0046332] | 66586.89280911826 | -0.31139077054671 | 7.26759689965964E-9 | 1.70997116493818E-7 |
| Q9BZF9 | Q9BZF9 | UACA_HUMAN | Uveal autoantigen with coiled-coil domains and ankyrin repeats | UACA | negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223] | cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | 10651.687309699351 | -0.463425510566727 | 7.27326245587894E-9 | 1.70997116493818E-7 | |
| Q99439 | Q99439 | CNN2_HUMAN | Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin) | CNN2 | actin filament organization [GO:0007015]; actomyosin structure organization [GO:0031032]; cellular response to mechanical stimulus [GO:0071260]; cytoskeleton organization [GO:0007010]; establishment of localization in cell [GO:0051649]; hemopoiesis [GO:0030097]; macrophage migration [GO:1905517]; negative regulation of macrophage migration [GO:1905522]; negative regulation of phagocytosis [GO:0050765]; phagocytosis [GO:0006909]; positive regulation of gene expression [GO:0010628]; regulation of actin filament-based process [GO:0032970]; regulation of mononuclear cell proliferation [GO:0032944]; wound healing [GO:0042060] | actin cytoskeleton [GO:0015629]; cell-cell junction [GO:0005911]; cytoskeleton [GO:0005856]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; membrane [GO:0016020]; specific granule lumen [GO:0035580]; stress fiber [GO:0001725]; tertiary granule lumen [GO:1904724] | actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516] | 278329.093953397 | -0.366084201405807 | 7.34830388780227E-9 | 1.72047478629288E-7 |
| Q5T4B2 | Q5T4B2 | GT253_HUMAN | Inactive glycosyltransferase 25 family member 3 (Cerebral endothelial cell adhesion molecule) | CERCAM | cell adhesion [GO:0007155]; leukocyte cell-cell adhesion [GO:0007159] | endoplasmic reticulum lumen [GO:0005788]; plasma membrane [GO:0005886] | identical protein binding [GO:0042802] | 20955.9296079942 | -0.435106780816426 | 7.77633610555711E-9 | 1.81319836930397E-7 |
| P09417 | P09417 | DHPR_HUMAN | Dihydropteridine reductase (EC 1.5.1.34) (HDHPR) (Quinoid dihydropteridine reductase) (Short chain dehydrogenase/reductase family 33C member 1) | QDPR | amino acid metabolic process [GO:0006520]; dihydrobiopterin metabolic process [GO:0051066]; L-phenylalanine catabolic process [GO:0006559]; tetrahydrobiopterin biosynthetic process [GO:0006729] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] | 6,7-dihydropteridine reductase activity [GO:0004155]; electron transfer activity [GO:0009055]; NADH binding [GO:0070404]; NADPH binding [GO:0070402] | 27632.34336691355 | -0.991987228108981 | 8.37103192984429E-9 | 1.94386339813515E-7 |
| P61019 | P61019 | RAB2A_HUMAN | Ras-related protein Rab-2A (EC 3.6.5.2) | RAB2A | endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; macroautophagy [GO:0016236]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] | acrosomal vesicle [GO:0001669]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; nucleus [GO:0005634] | GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] | 187651.1088778665 | -0.370645954178439 | 8.52261813739334E-9 | 1.97098589250901E-7 |
| Q9Y296 | Q9Y296 | TPPC4_HUMAN | Trafficking protein particle complex subunit 4 (Hematopoietic stem/progenitor cell protein 172) (Synbindin) (TRS23 homolog) | TRAPPC4 | autophagy [GO:0006914]; COPII vesicle coating [GO:0048208]; dendrite development [GO:0016358]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072] | 9066.950628230785 | -0.792100177382859 | 8.66413876943765E-9 | 1.99556952307454E-7 | |
| P09038 | P09038 | FGF2_HUMAN | Fibroblast growth factor 2 (FGF-2) (Basic fibroblast growth factor) (bFGF) (Heparin-binding growth factor 2) (HBGF-2) | FGF2 | angiogenesis involved in coronary vascular morphogenesis [GO:0060978]; animal organ morphogenesis [GO:0009887]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to mechanical stimulus [GO:0071260]; cerebellar granule cell precursor proliferation [GO:0021930]; chemotaxis [GO:0006935]; chondroblast differentiation [GO:0060591]; corticotropin hormone secreting cell differentiation [GO:0060128]; embryo development ending in birth or egg hatching [GO:0009792]; embryonic morphogenesis [GO:0048598]; endothelial cell proliferation [GO:0001935]; ERK1 and ERK2 cascade [GO:0070371]; fibroblast growth factor receptor signaling pathway [GO:0008543]; glial cell differentiation [GO:0010001]; growth factor dependent regulation of skeletal muscle satellite cell proliferation [GO:0014843]; hyaluronan catabolic process [GO:0030214]; inner ear auditory receptor cell differentiation [GO:0042491]; lung development [GO:0030324]; lymphatic endothelial cell migration [GO:1904977]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of gene expression [GO:0010629]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of wound healing [GO:0061045]; nervous system development [GO:0007399]; neuroblast proliferation [GO:0007405]; organ induction [GO:0001759]; osteoblast differentiation [GO:0001649]; paracrine signaling [GO:0038001]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell division [GO:0051781]; positive regulation of cell fate specification [GO:0042660]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cerebellar granule cell precursor proliferation [GO:0021940]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000546]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial tube formation [GO:1905278]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of inner ear auditory receptor cell differentiation [GO:0045609]; positive regulation of lens fiber cell differentiation [GO:1902748]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuroepithelial cell differentiation [GO:1902913]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; Ras protein signal transduction [GO:0007265]; regulation of angiogenesis [GO:0045765]; regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903587]; regulation of cell cycle [GO:0051726]; regulation of cell migration involved in sprouting angiogenesis [GO:0090049]; regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000544]; regulation of retinal cell programmed cell death [GO:0046668]; release of sequestered calcium ion into cytosol [GO:0051209]; response to axon injury [GO:0048678]; signal transduction [GO:0007165]; stem cell development [GO:0048864]; stem cell proliferation [GO:0072089]; substantia nigra development [GO:0021762]; thyroid-stimulating hormone-secreting cell differentiation [GO:0060129]; transcription by RNA polymerase II [GO:0006366]; wound healing [GO:0042060] | cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634] | chemoattractant activity [GO:0042056]; chemokine binding [GO:0019956]; cytokine activity [GO:0005125]; fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; nuclear receptor coactivator activity [GO:0030374]; receptor-receptor interaction [GO:0090722] | 56175.4559733152 | 0.933655164991493 | 1.02484257970824E-8 | 2.35091419296635E-7 |
| Q969P0 | Q969P0 | IGSF8_HUMAN | Immunoglobulin superfamily member 8 (IgSF8) (CD81 partner 3) (Glu-Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes-associated transmembrane protein 4) (KCT-4) (LIR-D1) (Prostaglandin regulatory-like protein) (PGRL) (CD antigen CD316) | IGSF8 | cell motility [GO:0048870]; nervous system development [GO:0007399]; single fertilization [GO:0007338]; skeletal muscle tissue development [GO:0007519] | extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886] | 23658.606788373247 | 0.562646190573165 | 1.16049216084808E-8 | 2.65135023522792E-7 | |
| P00390 | P00390 | GSHR_HUMAN | Glutathione reductase, mitochondrial (GR) (GRase) (EC 1.8.1.7) | GSR | cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; glutathione metabolic process [GO:0006749] | cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] | electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; glutathione-disulfide reductase (NADP) activity [GO:0004362]; NADP binding [GO:0050661] | 13078.697158771301 | 0.470245467186345 | 1.17964637979925E-8 | 2.68428770600102E-7 |
| O95336 | O95336 | 6PGL_HUMAN | 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31) | PGLS | carbohydrate metabolic process [GO:0005975]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, oxidative branch [GO:0009051] | cytosol [GO:0005829]; extracellular exosome [GO:0070062] | 6-phosphogluconolactonase activity [GO:0017057] | 36869.5336287917 | -0.970772914016039 | 1.18516214538906E-8 | 2.68605148630977E-7 |
| O95571 | O95571 | ETHE1_HUMAN | Persulfide dioxygenase ETHE1, mitochondrial (EC 1.13.11.18) (Ethylmalonic encephalopathy protein 1) (Hepatoma subtracted clone one protein) (Sulfur dioxygenase ETHE1) | ETHE1 | glutathione metabolic process [GO:0006749]; hydrogen sulfide metabolic process [GO:0070813] | cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] | identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; sulfur dioxygenase activity [GO:0050313] | 37784.27023216615 | 0.28348639753377 | 1.22925130536968E-8 | 2.77487565586639E-7 |
| P35520 | P35520 | CBS_HUMAN | Cystathionine beta-synthase (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase) | CBS | blood vessel diameter maintenance [GO:0097746]; blood vessel remodeling [GO:0001974]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cellular response to hypoxia [GO:0071456]; cerebellum morphogenesis [GO:0021587]; cysteine biosynthetic process [GO:0019344]; cysteine biosynthetic process from serine [GO:0006535]; cysteine biosynthetic process via cystathionine [GO:0019343]; DNA protection [GO:0042262]; endochondral ossification [GO:0001958]; homocysteine catabolic process [GO:0043418]; homocysteine metabolic process [GO:0050667]; hydrogen sulfide biosynthetic process [GO:0070814]; L-cysteine catabolic process [GO:0019448]; L-serine catabolic process [GO:0006565]; L-serine metabolic process [GO:0006563]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of apoptotic process [GO:0043066]; regulation of nitric oxide mediated signal transduction [GO:0010749]; response to folic acid [GO:0051593]; superoxide metabolic process [GO:0006801]; transsulfuration [GO:0019346] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] | carbon monoxide binding [GO:0070025]; cystathionine beta-synthase activity [GO:0004122]; cysteine synthase activity [GO:0004124]; enzyme binding [GO:0019899]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; L-cysteine desulfhydrase activity [GO:0080146]; metal ion binding [GO:0046872]; modified amino acid binding [GO:0072341]; nitric oxide binding [GO:0070026]; nitrite reductase (NO-forming) activity [GO:0050421]; oxygen binding [GO:0019825]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; S-adenosyl-L-methionine binding [GO:1904047]; ubiquitin protein ligase binding [GO:0031625] | 30529.470733438153 | -0.385723363487796 | 1.37202358146809E-8 | 3.08487524309452E-7 |
| P18084 | P18084 | ITB5_HUMAN | Integrin beta-5 | ITGB5 | cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; endodermal cell differentiation [GO:0035987]; epithelial cell-cell adhesion [GO:0090136]; integrin-mediated signaling pathway [GO:0007229]; stress fiber assembly [GO:0043149]; transforming growth factor beta receptor signaling pathway [GO:0007179]; wound healing, spreading of epidermal cells [GO:0035313] | cell surface [GO:0009986]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; integrin alphav-beta5 complex [GO:0034684]; integrin complex [GO:0008305]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] | integrin binding [GO:0005178]; metal ion binding [GO:0046872]; virus receptor activity [GO:0001618] | 26719.38450100185 | -0.60076124497519 | 1.42809204473797E-8 | 3.1982488243025E-7 |
| Q9Y3I0 | Q9Y3I0 | RTCB_HUMAN | RNA-splicing ligase RtcB homolog (EC 6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase) | RTCB | in utero embryonic development [GO:0001701]; placenta development [GO:0001890]; tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate [GO:0000971]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA-splicing ligase complex [GO:0072669] | GTP binding [GO:0005525]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA ligase (ATP) activity [GO:0003972]; vinculin binding [GO:0017166] | 72306.13785313435 | -0.201710495170347 | 1.48403228569622E-8 | 3.31044367352551E-7 |
| Q9UNZ2 | Q9UNZ2 | NSF1C_HUMAN | NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) | NSFL1C | autophagosome assembly [GO:0000045]; establishment of mitotic spindle orientation [GO:0000132]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; negative regulation of protein localization to centrosome [GO:1904780]; nuclear membrane reassembly [GO:0031468]; positive regulation of mitotic centrosome separation [GO:0046604]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; ubiquitin-dependent protein catabolic process [GO:0006511] | centrosome [GO:0005813]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi stack [GO:0005795]; nucleus [GO:0005634]; VCP-NSFL1C complex [GO:1990730] | lipid binding [GO:0008289]; ubiquitin binding [GO:0043130] | 46450.720635785794 | 0.474756395228408 | 1.50668240330715E-8 | 3.34778921456404E-7 |
| Q6P9B6 | Q6P9B6 | MEAK7_HUMAN | MTOR-associated protein MEAK7 (MEAK7) (MTOR associated protein, eak-7 homolog) (TBC/LysM-associated domain-containing protein 1) (TLD domain-containing protein 1) | MEAK7 | negative regulation of cellular response to oxidative stress [GO:1900408]; positive regulation of protein localization to lysosome [GO:0150032]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]; response to amino acid [GO:0043200]; response to insulin [GO:0032868]; response to nutrient levels [GO:0031667]; TOR signaling [GO:0031929] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] | 18980.4868286613 | 0.31168731315617 | 1.54144355629648E-8 | 3.41164812108432E-7 | |
| P40189 | P40189 | IL6RB_HUMAN | Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130) | IL6ST | ciliary neurotrophic factor-mediated signaling pathway [GO:0070120]; cytokine-mediated signaling pathway [GO:0019221]; glycogen metabolic process [GO:0005977]; interleukin-11-mediated signaling pathway [GO:0038154]; interleukin-27-mediated signaling pathway [GO:0070106]; interleukin-6-mediated signaling pathway [GO:0070102]; intestinal epithelial cell development [GO:0060576]; leukemia inhibitory factor signaling pathway [GO:0048861]; negative regulation of apoptotic process [GO:0043066]; negative regulation of interleukin-6-mediated signaling pathway [GO:0070104]; negative regulation of neuron apoptotic process [GO:0043524]; oncostatin-M-mediated signaling pathway [GO:0038165]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of platelet aggregation [GO:1901731]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vascular endothelial growth factor production [GO:0010575]; response to cytokine [GO:0034097]; T-helper 17 cell lineage commitment [GO:0072540] | ciliary neurotrophic factor receptor complex [GO:0070110]; dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; interleukin-6 receptor complex [GO:0005896]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; oncostatin-M receptor complex [GO:0005900]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] | ciliary neurotrophic factor receptor activity [GO:0004897]; ciliary neurotrophic factor receptor binding [GO:0005127]; coreceptor activity [GO:0015026]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; interleukin-11 binding [GO:0019970]; interleukin-11 receptor activity [GO:0004921]; interleukin-27 receptor activity [GO:0045509]; interleukin-6 binding [GO:0019981]; interleukin-6 receptor activity [GO:0004915]; protein tyrosine kinase activator activity [GO:0030296]; scaffold protein binding [GO:0097110] | 13076.1386046357 | 0.595040888788809 | 1.58448115576016E-8 | 3.49325689826346E-7 |
| Q13557 | Q13557 | KCC2D_HUMAN | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | CAMK2D | cardiac muscle cell contraction [GO:0086003]; cellular response to calcium ion [GO:0071277]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; negative regulation of sodium ion transmembrane transport [GO:1902306]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; regulation of cardiac muscle cell action potential [GO:0098901]; regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of cell growth [GO:0001558]; regulation of cellular localization [GO:0060341]; regulation of heart contraction [GO:0008016]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane depolarization [GO:0003254]; regulation of relaxation of cardiac muscle [GO:1901897]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; regulation of the force of heart contraction [GO:0002026]; regulation of transcription by RNA polymerase II [GO:0006357]; relaxation of cardiac muscle [GO:0055119] | calcium- and calmodulin-dependent protein kinase complex [GO:0005954]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sarcolemma [GO:0042383]; sarcoplasmic reticulum membrane [GO:0033017] | ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; sodium channel inhibitor activity [GO:0019871]; titin binding [GO:0031432]; transmembrane transporter binding [GO:0044325] | 70658.96003155175 | 0.25573525142346 | 1.96327000030559E-8 | 4.31158442702771E-7 |
| P38117 | P38117 | ETFB_HUMAN | Electron transfer flavoprotein subunit beta (Beta-ETF) | ETFB | amino acid catabolic process [GO:0009063]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; respiratory electron transport chain [GO:0022904] | cytosol [GO:0005829]; electron transfer flavoprotein complex [GO:0045251]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] | electron transfer activity [GO:0009055] | 87368.20393385604 | -0.354964367115561 | 1.9755729724655E-8 | 4.32185191582608E-7 |
| Q7LGA3 | Q7LGA3 | HS2ST_HUMAN | Heparan sulfate 2-O-sulfotransferase 1 (2-O-sulfotransferase) (2OST) (EC 2.8.2.-) | HS2ST1 | gene expression [GO:0010467]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin metabolic process [GO:0030202]; ureteric bud formation [GO:0060676] | Golgi membrane [GO:0000139]; membrane [GO:0016020] | heparan sulfate 2-O-sulfotransferase activity [GO:0004394] | 18467.99988509525 | 0.918073473743794 | 2.04283300316092E-8 | 4.45180453688838E-7 |
| P50453 | P50453 | SPB9_HUMAN | Serpin B9 (Cytoplasmic antiproteinase 3) (CAP-3) (CAP3) (Peptidase inhibitor 9) (PI-9) | SERPINB9 | cellular response to estrogen stimulus [GO:0071391]; immune response [GO:0006955]; mast cell mediated immunity [GO:0002448]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endopeptidase activity [GO:0010951]; protection from natural killer cell mediated cytotoxicity [GO:0042270] | collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867] | 15425.36380067685 | 0.494783371154111 | 2.1108024030105E-8 | 4.58230130860441E-7 |
| Q9BWM7 | Q9BWM7 | SFXN3_HUMAN | Sideroflexin-3 | SFXN3 | mitochondrial transmembrane transport [GO:1990542]; one-carbon metabolic process [GO:0006730]; serine import into mitochondrion [GO:0140300] | mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] | L-serine transmembrane transporter activity [GO:0015194]; monoatomic ion transmembrane transporter activity [GO:0015075] | 9696.28896343054 | -1.45998053545008 | 2.25082975537491E-8 | 4.86763411982987E-7 |
| P05155 | P05155 | IC1_HUMAN | Plasma protease C1 inhibitor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor) (Serpin G1) | SERPING1 | blood circulation [GO:0008015]; blood coagulation [GO:0007596]; complement activation, classical pathway [GO:0006958]; fibrinolysis [GO:0042730]; innate immune response [GO:0045087]; negative regulation of complement activation, lectin pathway [GO:0001869] | blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093] | serine-type endopeptidase inhibitor activity [GO:0004867] | 5289.820006431964 | 1.43942764469513 | 2.37689539655724E-8 | 5.12071837144233E-7 |
| Q9P299 | Q9P299 | COPZ2_HUMAN | Coatomer subunit zeta-2 (Zeta-2-coat protein) (Zeta-2 COP) | COPZ2 | intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890] | cis-Golgi network [GO:0005801]; COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133] | 51957.3133412346 | -1.25172137635507 | 2.39096578996037E-8 | 5.13151975981646E-7 | |
| P49023 | P49023 | PAXI_HUMAN | Paxillin | PXN | cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; endothelial cell migration [GO:0043542]; growth hormone receptor signaling pathway [GO:0060396]; positive regulation of stress fiber assembly [GO:0051496]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165]; substrate adhesion-dependent cell spreading [GO:0034446]; transforming growth factor beta receptor signaling pathway [GO:0007179] | cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; microtubule associated complex [GO:0005875]; plasma membrane [GO:0005886]; stress fiber [GO:0001725] | beta-catenin binding [GO:0008013]; metal ion binding [GO:0046872]; neuropilin binding [GO:0038191]; protein phosphatase binding [GO:0019903]; vinculin binding [GO:0017166] | 28941.627032964803 | 0.28487259689595 | 2.4238482792426E-8 | 5.18246201893909E-7 |
| Q8TDX7 | Q8TDX7 | NEK7_HUMAN | Serine/threonine-protein kinase Nek7 (EC 2.7.11.34) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7) | NEK7 | cellular response to potassium ion [GO:0035865]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein phosphorylation [GO:0006468]; regulation of mitotic cell cycle [GO:0007346]; spindle assembly [GO:0051225] | centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922] | ATP binding [GO:0005524]; metal ion binding [GO:0046872]; molecular function activator activity [GO:0140677]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | 51349.83790627025 | -0.443587323146282 | 2.62346537220207E-8 | 5.58817849582591E-7 |
| Q14254 | Q14254 | FLOT2_HUMAN | Flotillin-2 (Epidermal surface antigen) (ESA) (Membrane component chromosome 17 surface marker 1) | FLOT2 | anterograde dendritic transport [GO:0098937]; cell adhesion [GO:0007155]; epidermis development [GO:0008544]; negative regulation of amyloid precursor protein catabolic process [GO:1902992]; negative regulation of gene expression [GO:0010629]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of establishment of T cell polarity [GO:1903905]; protein localization to plasma membrane [GO:0072659]; protein localization to plasma membrane raft [GO:0044860]; protein stabilization [GO:0050821]; regulation of myoblast differentiation [GO:0045661]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072] | acrosomal membrane [GO:0002080]; adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; cell-cell contact zone [GO:0044291]; cytoplasmic vesicle [GO:0031410]; dendrite cytoplasm [GO:0032839]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; uropod [GO:0001931]; vesicle [GO:0031982] | 28298.56175049435 | -0.308530292906835 | 2.64464307688488E-8 | 5.61219013993622E-7 | |
| P27144 | P27144 | KAD4_HUMAN | Adenylate kinase 4, mitochondrial (AK 4) (EC 2.7.4.10) (EC 2.7.4.6) (Adenylate kinase 3-like) (GTP:AMP phosphotransferase AK4) | AK4 | ADP biosynthetic process [GO:0006172]; AMP metabolic process [GO:0046033]; ATP metabolic process [GO:0046034]; cellular response to hypoxia [GO:0071456]; GTP metabolic process [GO:0046039]; nucleobase-containing small molecule interconversion [GO:0015949]; nucleoside triphosphate biosynthetic process [GO:0009142]; phosphorylation [GO:0016310]; regulation of oxidative phosphorylation [GO:0002082]; ribonucleoside diphosphate biosynthetic process [GO:0009188] | cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] | adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; nucleoside diphosphate kinase activity [GO:0004550]; nucleoside monophosphate kinase activity [GO:0050145]; nucleoside triphosphate adenylate kinase activity [GO:0046899] | 49467.6956770744 | 0.474930182012076 | 2.6805206865248E-8 | 5.66710082457072E-7 |
| P28300 | P28300 | LYOX_HUMAN | Protein-lysine 6-oxidase (EC 1.4.3.13) (Lysyl oxidase) [Cleaved into: Protein-lysine 6-oxidase, long form; Protein-lysine 6-oxidase, short form] | LOX | ascending aorta development [GO:0035905]; blood vessel morphogenesis [GO:0048514]; bone mineralization [GO:0030282]; cell chemotaxis [GO:0060326]; cellular response to chemokine [GO:1990869]; collagen fibril organization [GO:0030199]; connective tissue development [GO:0061448]; descending aorta development [GO:0035906]; DNA biosynthetic process [GO:0071897]; elastic fiber assembly [GO:0048251]; heart development [GO:0007507]; lung development [GO:0030324]; muscle cell cellular homeostasis [GO:0046716]; muscle cell development [GO:0055001]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; osteoblast differentiation [GO:0001649]; peptidyl-lysine oxidation [GO:0018057]; platelet-derived growth factor receptor-beta signaling pathway [GO:0035791]; protein modification process [GO:0036211]; regulation of apoptotic process [GO:0042981]; regulation of bone development [GO:1903010]; regulation of gene expression [GO:0010468]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000586]; regulation of protein phosphorylation [GO:0001932]; regulation of striated muscle tissue development [GO:0016202]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to steroid hormone [GO:0048545]; response to xenobiotic stimulus [GO:0009410] | collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615] | collagen binding [GO:0005518]; copper ion binding [GO:0005507]; molecular adaptor activity [GO:0060090]; protein-lysine 6-oxidase activity [GO:0004720]; small molecule binding [GO:0036094] | 86523.53465674256 | 0.509879176817499 | 2.92584087698657E-8 | 6.16275628587581E-7 |
| Q92692 | Q92692 | NECT2_HUMAN | Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112) | NECTIN2 | acrosome assembly [GO:0001675]; adhesion of symbiont to host [GO:0044406]; cilium organization [GO:0044782]; coreceptor-mediated virion attachment to host cell [GO:0046814]; cytoskeleton organization [GO:0007010]; establishment of localization in cell [GO:0051649]; establishment of mitochondrion localization [GO:0051654]; fertilization [GO:0009566]; fusion of virus membrane with host plasma membrane [GO:0019064]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; positive regulation of immunoglobulin mediated immune response [GO:0002891]; positive regulation of mast cell activation [GO:0033005]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002860]; positive regulation of T cell receptor signaling pathway [GO:0050862]; regulation of viral entry into host cell [GO:0046596]; sperm mitochondrion organization [GO:0030382]; spermatid development [GO:0007286]; spermatid nucleus differentiation [GO:0007289]; susceptibility to natural killer cell mediated cytotoxicity [GO:0042271]; susceptibility to T cell mediated cytotoxicity [GO:0060370] | apical junction complex [GO:0043296]; cell surface [GO:0009986]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; zonula adherens [GO:0005915] | cell adhesion molecule binding [GO:0050839]; coreceptor activity [GO:0015026]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; virus receptor activity [GO:0001618] | 15085.36146214925 | 0.581958685386207 | 3.1812291208319E-8 | 6.67586822171614E-7 |
| P21281 | P21281 | VATB2_HUMAN | V-type proton ATPase subunit B, brain isoform (V-ATPase subunit B 2) (Endomembrane proton pump 58 kDa subunit) (HO57) (Vacuolar proton pump subunit B 2) | ATP6V1B2 | ATP metabolic process [GO:0046034]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035] | apical plasma membrane [GO:0016324]; clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of synaptic vesicle membrane [GO:0098850]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221] | ATP binding [GO:0005524]; proton transmembrane transporter activity [GO:0015078]; proton-transporting ATPase activity, rotational mechanism [GO:0046961] | 55903.283751695155 | -0.146618483170213 | 3.31687294052511E-8 | 6.90933900037327E-7 |
| P46060 | P46060 | RAGP1_HUMAN | Ran GTPase-activating protein 1 (RanGAP1) | RANGAP1 | activation of GTPase activity [GO:0090630]; cellular response to vasopressin [GO:1904117]; negative regulation of protein export from nucleus [GO:0046826]; nuclear export [GO:0051168]; nucleocytoplasmic transport [GO:0006913]; protein sumoylation [GO:0016925]; response to axon injury [GO:0048678]; signal transduction [GO:0007165] | aggresome [GO:0016235]; axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytoplasmic periphery of the nuclear pore complex [GO:1990723]; cytosol [GO:0005829]; dendrite [GO:0030425]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; mitotic spindle [GO:0072686]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore cytoplasmic filaments [GO:0044614]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; SUMO ligase complex [GO:0106068] | cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; ubiquitin protein ligase binding [GO:0031625] | 27708.038108802 | 0.227930664121736 | 3.30954352776663E-8 | 6.90933900037327E-7 |
| Q7Z417 | Q7Z417 | NUFP2_HUMAN | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | NUFIP2 | cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribosome [GO:0005840] | RNA binding [GO:0003723] | 28872.8728186973 | 0.388484679062277 | 3.78197455663949E-8 | 7.84932887835875E-7 | |
| Q8WUP2 | Q8WUP2 | FBLI1_HUMAN | Filamin-binding LIM protein 1 (FBLP-1) (Migfilin) (Mitogen-inducible 2-interacting protein) (MIG2-interacting protein) | FBLIM1 | cell-cell adhesion [GO:0098609]; regulation of cell shape [GO:0008360]; regulation of integrin activation [GO:0033623] | cell junction [GO:0030054]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; focal adhesion [GO:0005925]; stress fiber [GO:0001725] | filamin binding [GO:0031005]; metal ion binding [GO:0046872] | 42697.52639806215 | -0.382716154499224 | 3.86403507567897E-8 | 7.99037326233469E-7 |
| Q9BS26 | Q9BS26 | ERP44_HUMAN | Endoplasmic reticulum resident protein 44 (ER protein 44) (ERp44) (Thioredoxin domain-containing protein 4) | ERP44 | cell redox homeostasis [GO:0045454]; glycoprotein metabolic process [GO:0009100]; protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986] | cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; specific granule lumen [GO:0035580] | protein disulfide isomerase activity [GO:0003756] | 72082.5097259114 | 0.287469946349156 | 4.01398768147439E-8 | 8.27027425572141E-7 |
| Q9HBL0 | Q9HBL0 | TENS1_HUMAN | Tensin-1 (EC 3.1.3.-) | TNS1 | cell-substrate junction assembly [GO:0007044]; fibroblast migration [GO:0010761] | cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925] | actin binding [GO:0003779]; metal ion binding [GO:0046872]; phosphoprotein phosphatase activity [GO:0004721]; RNA binding [GO:0003723] | 14767.32192601825 | -0.287007963369174 | 4.08684963203525E-8 | 8.38988768663468E-7 |
| O76003 | O76003 | GLRX3_HUMAN | Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2) | GLRX3 | [2Fe-2S] cluster assembly [GO:0044571]; cell redox homeostasis [GO:0045454]; intracellular iron ion homeostasis [GO:0006879]; iron-sulfur cluster assembly [GO:0016226]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; protein maturation by iron-sulfur cluster transfer [GO:0097428]; regulation of the force of heart contraction [GO:0002026] | cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; iron-sulfur cluster assembly complex [GO:1990229]; nucleus [GO:0005634]; Z disc [GO:0030018] | 2 iron, 2 sulfur cluster binding [GO:0051537]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein kinase C binding [GO:0005080]; RNA binding [GO:0003723] | 52347.3089016042 | 0.313804094238059 | 4.10845967373083E-8 | 8.40380235067108E-7 |
| Q9HB71 | Q9HB71 | CYBP_HUMAN | Calcyclin-binding protein (CacyBP) (hCacyBP) (S100A6-binding protein) (Siah-interacting protein) | CACYBP | cellular response to leukemia inhibitory factor [GO:1990830]; heart development [GO:0007507] | beta-catenin destruction complex [GO:0030877]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear envelope lumen [GO:0005641]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005] | protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; S100 protein binding [GO:0044548]; tubulin binding [GO:0015631]; ubiquitin protein ligase binding [GO:0031625] | 51899.2176152881 | 0.532289678437303 | 4.18805609162805E-8 | 8.53580065293688E-7 |
| O15427 | O15427 | MOT4_HUMAN | Monocarboxylate transporter 4 (MCT 4) (Solute carrier family 16 member 3) | SLC16A3 | lactate transmembrane transport [GO:0035873]; monocarboxylic acid transport [GO:0015718]; protein catabolic process [GO:0030163]; pyruvate catabolic process [GO:0042867]; pyruvate transmembrane transport [GO:1901475] | apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; synapse [GO:0045202] | lactate:proton symporter activity [GO:0015650]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; pyruvate transmembrane transporter activity [GO:0050833]; RNA binding [GO:0003723] | 70459.6962745434 | -0.718605483219749 | 4.22680721603949E-8 | 8.58390311329023E-7 |
| P24539 | P24539 | AT5F1_HUMAN | ATP synthase F(0) complex subunit B1, mitochondrial (ATP synthase peripheral stalk-membrane subunit b) (ATP synthase proton-transporting mitochondrial F(0) complex subunit B1) (ATP synthase subunit b) (ATPase subunit b) | ATP5PB | proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; substantia nigra development [GO:0021762] | membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]; mitochondrion [GO:0005739]; nucleus [GO:0005634] | proton-transporting ATP synthase activity, rotational mechanism [GO:0046933] | 56392.11119248635 | -1.07107824750368 | 4.38079171150351E-8 | 8.86484494192103E-7 |
| P03956 | P03956 | MMP1_HUMAN | Interstitial collagenase (EC 3.4.24.7) (Fibroblast collagenase) (Matrix metalloproteinase-1) (MMP-1) [Cleaved into: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase] | MMP1 | cellular response to UV-A [GO:0071492]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; positive regulation of protein-containing complex assembly [GO:0031334]; protein metabolic process [GO:0019538]; proteolysis [GO:0006508] | extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615] | endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270] | 15173.6178018096 | 0.8221170828575 | 4.72884846574714E-8 | 9.53510868573782E-7 |
| Q14699 | Q14699 | RFTN1_HUMAN | Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein) | RFTN1 | B cell receptor signaling pathway [GO:0050853]; dsRNA transport [GO:0033227]; membrane raft assembly [GO:0001765]; positive regulation of growth rate [GO:0040010]; positive regulation of interleukin-17 production [GO:0032740]; protein localization to membrane raft [GO:1903044]; protein transport into membrane raft [GO:0032596]; response to exogenous dsRNA [GO:0043330]; T cell antigen processing and presentation [GO:0002457]; T cell receptor signaling pathway [GO:0050852]; toll-like receptor 3 signaling pathway [GO:0034138] | cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] | double-stranded RNA binding [GO:0003725] | 26782.16427402315 | 0.324717093781969 | 4.96387962933265E-8 | 9.97352552475134E-7 |
| P07099 | P07099 | HYEP_HUMAN | Epoxide hydrolase 1 (EC 3.3.2.9) (Epoxide hydratase) (Microsomal epoxide hydrolase) (mEH) | EPHX1 | arachidonic acid metabolic process [GO:0019369]; aromatic compound catabolic process [GO:0019439]; epoxide metabolic process [GO:0097176]; response to organic cyclic compound [GO:0014070]; response to toxic substance [GO:0009636]; xenobiotic metabolic process [GO:0006805] | endoplasmic reticulum membrane [GO:0005789] | cis-stilbene-oxide hydrolase activity [GO:0033961]; epoxide hydrolase activity [GO:0004301]; oxysterol binding [GO:0008142] | 28569.59650970455 | 0.396750437803257 | 5.02385712268791E-8 | 1.00583655325617E-6 |
| P37802 | P37802 | TAGL2_HUMAN | Transgelin-2 (Epididymis tissue protein Li 7e) (SM22-alpha homolog) | TAGLN2 | actin filament organization [GO:0007015]; epithelial cell differentiation [GO:0030855] | actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; vesicle [GO:0031982] | actin filament binding [GO:0051015]; cadherin binding [GO:0045296] | 682297.31390879 | -0.431662036849911 | 5.06385023499311E-8 | 1.01027378279827E-6 |
| P36897 | P36897 | TGFR1_HUMAN | TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I) | TGFBR1 | activin receptor signaling pathway [GO:0032924]; angiogenesis involved in coronary vascular morphogenesis [GO:0060978]; anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; artery morphogenesis [GO:0048844]; blastocyst development [GO:0001824]; cardiac epithelial to mesenchymal transition [GO:0060317]; cell motility [GO:0048870]; cellular response to growth factor stimulus [GO:0071363]; cellular response to transforming growth factor beta stimulus [GO:0071560]; collagen fibril organization [GO:0030199]; coronary artery morphogenesis [GO:0060982]; embryonic cranial skeleton morphogenesis [GO:0048701]; endothelial cell activation [GO:0042118]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; epicardium morphogenesis [GO:1905223]; epithelial to mesenchymal transition [GO:0001837]; extracellular structure organization [GO:0043062]; filopodium assembly [GO:0046847]; germ cell migration [GO:0008354]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; intracellular signal transduction [GO:0035556]; kidney development [GO:0001822]; lens development in camera-type eye [GO:0002088]; male gonad development [GO:0008584]; mesenchymal cell differentiation [GO:0048762]; myofibroblast differentiation [GO:0036446]; negative regulation of cell migration [GO:0030336]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; nervous system development [GO:0007399]; neuron fate commitment [GO:0048663]; parathyroid gland development [GO:0060017]; peptidyl-serine phosphorylation [GO:0018105]; pharyngeal system development [GO:0060037]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905007]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of gene expression [GO:0010628]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of tight junction disassembly [GO:1905075]; positive regulation of vasculature development [GO:1904018]; post-embryonic development [GO:0009791]; regulation of cardiac muscle cell proliferation [GO:0060043]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gene expression [GO:0010468]; regulation of protein ubiquitination [GO:0031396]; response to cholesterol [GO:0070723]; roof of mouth development [GO:0060021]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]; skeletal system morphogenesis [GO:0048705]; thymus development [GO:0048538]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ventricular compact myocardium morphogenesis [GO:0003223]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]; wound healing [GO:0042060] | activin receptor complex [GO:0048179]; bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; endosome [GO:0005768]; membrane [GO:0016020]; membrane raft [GO:0045121]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; transforming growth factor beta ligand-receptor complex [GO:0070021] | activin binding [GO:0048185]; activin receptor activity, type I [GO:0016361]; ATP binding [GO:0005524]; I-SMAD binding [GO:0070411]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; SMAD binding [GO:0046332]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]; transforming growth factor beta receptor activity, type I [GO:0005025]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675]; type II transforming growth factor beta receptor binding [GO:0005114]; ubiquitin protein ligase binding [GO:0031625] | 11377.878687738415 | -0.871725023170914 | 5.26631647481008E-8 | 1.04698067179908E-6 |
| P24752 | P24752 | THIL_HUMAN | Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (T2) | ACAT1 | acetyl-CoA biosynthetic process [GO:0006085]; acetyl-CoA catabolic process [GO:0046356]; adipose tissue development [GO:0060612]; coenzyme A biosynthetic process [GO:0015937]; coenzyme A metabolic process [GO:0015936]; fatty acid beta-oxidation [GO:0006635]; isoleucine catabolic process [GO:0006550]; ketone body catabolic process [GO:0046952]; ketone body metabolic process [GO:1902224]; liver development [GO:0001889]; metanephric proximal convoluted tubule development [GO:0072229]; propionyl-CoA biosynthetic process [GO:1902860]; response to hormone [GO:0009725]; response to organic cyclic compound [GO:0014070]; response to starvation [GO:0042594] | endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] | acetyl-CoA C-acetyltransferase activity [GO:0003985]; C-acetyltransferase activity [GO:0016453]; cholesterol O-acyltransferase activity [GO:0034736]; coenzyme A binding [GO:0120225]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; potassium ion binding [GO:0030955] | 32970.2079698237 | -0.450499408963455 | 5.66999526241171E-8 | 1.12329346702184E-6 |
| O43353 | O43353 | RIPK2_HUMAN | Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2) | RIPK2 | activation of cysteine-type endopeptidase activity [GO:0097202]; adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; CD4-positive, alpha-beta T cell proliferation [GO:0035739]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to muramyl dipeptide [GO:0071225]; cellular response to peptidoglycan [GO:0071224]; cytokine-mediated signaling pathway [GO:0019221]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; ERK1 and ERK2 cascade [GO:0070371]; immature T cell proliferation in thymus [GO:0033080]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; JNK cascade [GO:0007254]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070427]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; phosphorylation [GO:0016310]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of immature T cell proliferation in thymus [GO:0033092]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein binding [GO:0032092]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of stress-activated MAPK cascade [GO:0032874]; positive regulation of T-helper 1 cell differentiation [GO:0045627]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of xenophagy [GO:1904417]; protein homooligomerization [GO:0051260]; response to exogenous dsRNA [GO:0043330]; response to interleukin-1 [GO:0070555]; response to interleukin-12 [GO:0070671]; response to interleukin-18 [GO:0070673]; signal transduction [GO:0007165]; stress-activated MAPK cascade [GO:0051403]; T cell receptor signaling pathway [GO:0050852]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 4 signaling pathway [GO:0034142]; xenophagy [GO:0098792] | cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; vesicle [GO:0031982] | ATP binding [GO:0005524]; CARD domain binding [GO:0050700]; caspase binding [GO:0089720]; identical protein binding [GO:0042802]; JUN kinase kinase kinase activity [GO:0004706]; LIM domain binding [GO:0030274]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; signaling adaptor activity [GO:0035591]; signaling receptor binding [GO:0005102] | 9699.698034968585 | 0.776187888312199 | 5.74116404230568E-8 | 1.1334298070977E-6 |
| Q05639 | Q05639 | EF1A2_HUMAN | Elongation factor 1-alpha 2 (EF-1-alpha-2) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1) | EEF1A2 | positive regulation of apoptotic process [GO:0043065]; positive regulation of lipid kinase activity [GO:0090218]; regulation of chaperone-mediated autophagy [GO:1904714]; translation [GO:0006412]; translational elongation [GO:0006414] | cytoplasm [GO:0005737]; cytoplasmic side of lysosomal membrane [GO:0098574]; eukaryotic translation elongation factor 1 complex [GO:0005853]; synapse [GO:0045202] | GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; translation elongation factor activity [GO:0003746]; translation factor activity, RNA binding [GO:0008135] | 29519.147003459348 | 0.552542774014647 | 5.87222220990611E-8 | 1.15128065886948E-6 |
| P55769 | P55769 | NH2L1_HUMAN | NHP2-like protein 1 (High mobility group-like nuclear protein 2 homolog 1) (OTK27) (SNU13 homolog) (hSNU13) (U4/U6.U5 small nuclear ribonucleoprotein SNU13) (U4/U6.U5 tri-snRNP 15.5 kDa protein) [Cleaved into: NHP2-like protein 1, N-terminally processed] | SNU13 | box C/D snoRNP assembly [GO:0000492]; maturation of LSU-rRNA [GO:0000470]; maturation of SSU-rRNA [GO:0030490]; mRNA splicing, via spliceosome [GO:0000398]; ribosomal small subunit biogenesis [GO:0042274]; single fertilization [GO:0007338] | box C/D RNP complex [GO:0031428]; cytosolic large ribosomal subunit [GO:0022625]; dense fibrillar component [GO:0001651]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; protein-containing complex [GO:0032991]; small-subunit processome [GO:0032040]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U4atac snRNP [GO:0005690] | ATPase binding [GO:0051117]; box C/D RNA binding [GO:0034512]; RNA binding [GO:0003723]; U3 snoRNA binding [GO:0034511]; U4 snRNA binding [GO:0030621]; U4atac snRNA binding [GO:0030622] | 48023.803937798206 | -1.08696379833801 | 5.85662274254718E-8 | 1.15128065886948E-6 |
| O00429 | O00429 | DNM1L_HUMAN | Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) | DNM1L | calcium ion transport [GO:0006816]; endocytosis [GO:0006897]; heart contraction [GO:0060047]; intracellular distribution of mitochondria [GO:0048312]; membrane fusion [GO:0061025]; mitochondrial fission [GO:0000266]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial membrane fission [GO:0090149]; mitochondrion organization [GO:0007005]; mitocytosis [GO:0160040]; necroptotic process [GO:0070266]; peroxisome fission [GO:0016559]; positive regulation of apoptotic process [GO:0043065]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of protein secretion [GO:0050714]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; protein complex oligomerization [GO:0051259]; protein localization to mitochondrion [GO:0070585]; protein-containing complex assembly [GO:0065003]; regulation of ATP metabolic process [GO:1903578]; regulation of gene expression [GO:0010468]; regulation of mitochondrion organization [GO:0010821]; regulation of mitophagy [GO:1901524]; regulation of peroxisome organization [GO:1900063]; release of cytochrome c from mitochondria [GO:0001836]; rhythmic process [GO:0048511] | brush border [GO:0005903]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; synaptic vesicle membrane [GO:0030672] | GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]; ubiquitin protein ligase binding [GO:0031625] | 23539.8263779583 | -0.23584481989474 | 6.52893018100146E-8 | 1.2756178760536E-6 |
| P59998 | P59998 | ARPC4_HUMAN | Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC) | ARPC4 | actin filament polymerization [GO:0030041]; actin nucleation [GO:0045010]; Arp2/3 complex-mediated actin nucleation [GO:0034314] | Arp2/3 protein complex [GO:0005885]; cell projection [GO:0042995]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] | actin filament binding [GO:0051015]; enzyme binding [GO:0019899]; structural constituent of cytoskeleton [GO:0005200] | 82564.79837867295 | -1.3108931407423 | 6.56665690262257E-8 | 1.27858000035256E-6 |
| Q9UH99 | Q9UH99 | SUN2_HUMAN | SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2) | SUN2 | centrosome localization [GO:0051642]; meiotic cell cycle [GO:0051321]; mitotic spindle organization [GO:0007052]; nuclear matrix anchoring at nuclear membrane [GO:0090292]; nuclear migration [GO:0007097]; nuclear migration along microfilament [GO:0031022]; nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration [GO:0021817]; positive regulation of cell migration [GO:0030335] | chromosome, telomeric region [GO:0000781]; condensed nuclear chromosome [GO:0000794]; endosome membrane [GO:0010008]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965] | cytoskeleton-nuclear membrane anchor activity [GO:0140444]; identical protein binding [GO:0042802]; lamin binding [GO:0005521]; microtubule binding [GO:0008017]; protein-membrane adaptor activity [GO:0043495] | 15473.72782569595 | -0.289465154464146 | 6.84264067862028E-8 | 1.32775349606378E-6 |
| P20839 | P20839 | IMDH1_HUMAN | Inosine-5'-monophosphate dehydrogenase 1 (IMP dehydrogenase 1) (IMPD 1) (IMPDH 1) (EC 1.1.1.205) (IMPDH-I) | IMPDH1 | GMP biosynthetic process [GO:0006177]; GTP biosynthetic process [GO:0006183] | azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774] | DNA binding [GO:0003677]; identical protein binding [GO:0042802]; IMP dehydrogenase activity [GO:0003938]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; nucleotide binding [GO:0000166]; RNA binding [GO:0003723] | 15624.561538759 | -0.391048130961159 | 7.25210004567087E-8 | 1.40240269142564E-6 |
| Q96PP9 | Q96PP9 | GBP4_HUMAN | Guanylate-binding protein 4 (EC 3.6.5.-) (GTP-binding protein 4) (GBP-4) (Guanine nucleotide-binding protein 4) | GBP4 | cellular response to type II interferon [GO:0071346]; defense response to Gram-positive bacterium [GO:0050830]; defense response to protozoan [GO:0042832] | cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] | GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] | 5454.45816472045 | 1.20512869739396 | 7.56507282209575E-8 | 1.45794906836716E-6 |
| Q9UKX5 | Q9UKX5 | ITA11_HUMAN | Integrin alpha-11 | ITGA11 | cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; collagen-activated signaling pathway [GO:0038065]; integrin-mediated signaling pathway [GO:0007229]; muscle organ development [GO:0007517]; osteoblast differentiation [GO:0001649]; substrate-dependent cell migration [GO:0006929] | external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; integrin alpha11-beta1 complex [GO:0034681]; integrin complex [GO:0008305]; membrane [GO:0016020]; plasma membrane [GO:0005886] | collagen binding [GO:0005518]; collagen binding involved in cell-matrix adhesion [GO:0098639]; collagen receptor activity [GO:0038064]; integrin binding [GO:0005178]; metal ion binding [GO:0046872] | 7259.793271372966 | -1.83168160760003 | 7.59892191303459E-8 | 1.45950818844929E-6 |
| Q9UL46 | Q9UL46 | PSME2_HUMAN | Proteasome activator complex subunit 2 (11S regulator complex subunit beta) (REG-beta) (Activator of multicatalytic protease subunit 2) (Proteasome activator 28 subunit beta) (PA28b) (PA28beta) | PSME2 | regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of proteasomal protein catabolic process [GO:0061136] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; proteasome activator complex [GO:0008537]; proteasome complex [GO:0000502] | endopeptidase activator activity [GO:0061133]; identical protein binding [GO:0042802] | 49238.857196936646 | 0.67793265693098 | 7.68026556165804E-8 | 1.47014813082279E-6 |
| P33908 | P33908 | MA1A1_HUMAN | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Man(9)-alpha-mannosidase) (Man9-mannosidase) (Mannosidase alpha class 1A member 1) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) | MAN1A1 | carbohydrate metabolic process [GO:0005975]; ERAD pathway [GO:0036503]; mannose trimming involved in glycoprotein ERAD pathway [GO:1904382]; protein glycosylation [GO:0006486]; protein targeting to ER [GO:0045047] | cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] | calcium ion binding [GO:0005509]; mannosidase activity [GO:0015923]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571] | 12108.558277196486 | 0.836487501098787 | 7.93314861493632E-8 | 1.51344175260031E-6 |
| P28838 | P28838 | AMPL_HUMAN | Cytosol aminopeptidase (EC 3.4.11.1) (Cysteinylglycine-S-conjugate dipeptidase) (EC 3.4.13.23) (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (Peptidase S) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase) | LAP3 | proteolysis [GO:0006508] | cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802] | aminopeptidase activity [GO:0004177]; carboxypeptidase activity [GO:0004180]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; metalloexopeptidase activity [GO:0008235]; peptidase activity [GO:0008233] | 35035.3224628634 | 0.211857806889803 | 8.08146017278849E-8 | 1.53656219258455E-6 |
| P18085 | P18085 | ARF4_HUMAN | ADP-ribosylation factor 4 | ARF4 | apical protein localization [GO:0045176]; cell migration [GO:0016477]; cilium assembly [GO:0060271]; dendritic spine development [GO:0060996]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; intracellular protein transport [GO:0006886]; learning [GO:0007612]; negative regulation of apoptotic process [GO:0043066]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to cilium [GO:0061512]; regulation of cilium assembly [GO:1902017]; regulation of postsynapse organization [GO:0099175]; regulation of reactive oxygen species metabolic process [GO:2000377]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle-mediated transport [GO:0016192] | cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] | epidermal growth factor receptor binding [GO:0005154]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanyl-nucleotide exchange factor activity [GO:0005085]; NAD+-protein-arginine ADP-ribosyltransferase activity [GO:0106274]; phospholipase D activator activity [GO:1990583] | 122932.0522198505 | -1.19830731120463 | 8.36780951929131E-8 | 1.5856859109132E-6 |
| Q9Y3Q3 | Q9Y3Q3 | TMED3_HUMAN | Transmembrane emp24 domain-containing protein 3 (Membrane protein p24B) (p24 family protein gamma-4) (p24gamma4) (p26) | TMED3 | endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886] | COPI vesicle coat [GO:0030126]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133] | cargo receptor activity [GO:0038024] | 20982.698377430548 | -0.787040398328098 | 8.6316486172163E-8 | 1.63023070217158E-6 |
| O00442 | O00442 | RTCA_HUMAN | RNA 3'-terminal phosphate cyclase (RNA cyclase) (RNA-3'-phosphate cyclase) (EC 6.5.1.4) (RNA terminal phosphate cyclase domain-containing protein 1) (RTC domain-containing protein 1) | RTCA | negative regulation of optical nerve axon regeneration [GO:1905592]; RNA processing [GO:0006396] | nucleoplasm [GO:0005654]; nucleus [GO:0005634] | ATP binding [GO:0005524]; RNA binding [GO:0003723]; RNA-3'-phosphate cyclase activity [GO:0003963] | 21225.86159629875 | -0.455667860759827 | 9.09213541326909E-8 | 1.71149632065059E-6 |
| O94813 | O94813 | SLIT2_HUMAN | Slit homolog 2 protein (Slit-2) [Cleaved into: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product] | SLIT2 | aortic valve morphogenesis [GO:0003180]; apoptotic process involved in luteolysis [GO:0061364]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; branching morphogenesis of an epithelial tube [GO:0048754]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to heparin [GO:0071504]; cellular response to hormone stimulus [GO:0032870]; chemorepulsion involved in postnatal olfactory bulb interneuron migration [GO:0021836]; corticospinal neuron axon guidance through spinal cord [GO:0021972]; induction of negative chemotaxis [GO:0050929]; motor neuron axon guidance [GO:0008045]; negative chemotaxis [GO:0050919]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cellular response to growth factor stimulus [GO:0090288]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of lamellipodium assembly [GO:0010593]; negative regulation of leukocyte chemotaxis [GO:0002689]; negative regulation of monocyte chemotaxis [GO:0090027]; negative regulation of mononuclear cell migration [GO:0071676]; negative regulation of neutrophil chemotaxis [GO:0090024]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of retinal ganglion cell axon guidance [GO:0090260]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; negative regulation of smooth muscle cell chemotaxis [GO:0071672]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of vascular permeability [GO:0043116]; positive regulation of apoptotic process [GO:0043065]; positive regulation of axonogenesis [GO:0050772]; pulmonary valve morphogenesis [GO:0003184]; response to cortisol [GO:0051414]; retinal ganglion cell axon guidance [GO:0031290]; Roundabout signaling pathway [GO:0035385]; ureteric bud development [GO:0001657]; ventricular septum morphogenesis [GO:0060412] | cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020] | calcium ion binding [GO:0005509]; GTPase inhibitor activity [GO:0005095]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; laminin-1 binding [GO:0043237]; protein homodimerization activity [GO:0042803]; proteoglycan binding [GO:0043394]; Roundabout binding [GO:0048495] | 7352.4156537091 | -0.593411021727966 | 9.31622360211848E-8 | 1.74787162018554E-6 |
| P48047 | P48047 | ATPO_HUMAN | ATP synthase subunit O, mitochondrial (ATP synthase peripheral stalk subunit OSCP) (Oligomycin sensitivity conferral protein) (OSCP) | ATP5PO | ATP biosynthetic process [GO:0006754]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; proton transmembrane transport [GO:1902600] | mitochondrial inner membrane [GO:0005743]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase, stator stalk [GO:0000274]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261] | proton-transporting ATP synthase activity, rotational mechanism [GO:0046933] | 95294.25853570344 | -0.971879238573852 | 9.80129657663498E-8 | 1.83281011231729E-6 |
| O14908 | O14908 | GIPC1_HUMAN | PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin) (Tax interaction protein 2) (TIP-2) | GIPC1 | cellular response to interleukin-7 [GO:0098761]; chemical synaptic transmission [GO:0007268]; endothelial cell migration [GO:0043542]; G protein-coupled receptor signaling pathway [GO:0007186]; glutamate secretion [GO:0014047]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of cytokinesis [GO:0032467]; positive regulation of melanin biosynthetic process [GO:0048023]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein targeting [GO:0006605]; regulation of protein stability [GO:0031647]; regulation of synaptic plasticity [GO:0048167] | cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle [GO:0008021]; vesicle membrane [GO:0012506] | actin binding [GO:0003779]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; myosin binding [GO:0017022]; signaling receptor binding [GO:0005102] | 24276.1698024758 | 0.355759453398817 | 1.00639962431361E-7 | 1.87574351031609E-6 |
| P19971 | P19971 | TYPH_HUMAN | Thymidine phosphorylase (TP) (EC 2.4.2.4) (Gliostatin) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (TdRPase) | TYMP | AMP catabolic process [GO:0006196]; angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; chemotaxis [GO:0006935]; dTMP catabolic process [GO:0046074]; mitochondrial genome maintenance [GO:0000002]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside metabolic process [GO:0006213]; regulation of gastric motility [GO:1905333]; regulation of myelination [GO:0031641]; regulation of transmission of nerve impulse [GO:0051969] | cytosol [GO:0005829] | 1,4-alpha-oligoglucan phosphorylase activity [GO:0004645]; growth factor activity [GO:0008083]; protein homodimerization activity [GO:0042803]; pyrimidine-nucleoside phosphorylase activity [GO:0016154]; thymidine phosphorylase activity [GO:0009032] | 9890.807805174434 | -0.979349689749976 | 1.01133850152671E-7 | 1.87876850808208E-6 |
| P37235 | P37235 | HPCL1_HUMAN | Hippocalcin-like protein 1 (Calcium-binding protein BDR-1) (HLP2) (Visinin-like protein 3) (VILIP-3) | HPCAL1 | membrane [GO:0016020] | calcium ion binding [GO:0005509] | 15348.92582659165 | 0.72304708731873 | 1.05774006781148E-7 | 1.95854745889537E-6 | |
| P15559 | P15559 | NQO1_HUMAN | NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Azoreductase) (DT-diaphorase) (DTD) (Menadione reductase) (NAD(P)H:quinone oxidoreductase 1) (Phylloquinone reductase) (Quinone reductase 1) (QR1) | NQO1 | cell redox homeostasis [GO:0045454]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to metal ion [GO:0071248]; cellular response to oxidative stress [GO:0034599]; innate immune response [GO:0045087]; NADH oxidation [GO:0006116]; NADPH oxidation [GO:0070995]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein catabolic process [GO:0042177]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of neuron apoptotic process [GO:0043525]; protein catabolic process [GO:0030163]; protein polyubiquitination [GO:0000209]; removal of superoxide radicals [GO:0019430]; response to alkaloid [GO:0043279]; response to amine [GO:0014075]; response to carbohydrate [GO:0009743]; response to electrical stimulus [GO:0051602]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to flavonoid [GO:1905395]; response to hormone [GO:0009725]; response to hydrogen sulfide [GO:1904880]; response to ischemia [GO:0002931]; response to L-glutamine [GO:1904844]; response to lipopolysaccharide [GO:0032496]; response to nutrient [GO:0007584]; response to oxidative stress [GO:0006979]; response to testosterone [GO:0033574]; response to tetrachloromethane [GO:1904772]; response to toxic substance [GO:0009636]; synaptic transmission, cholinergic [GO:0007271]; ubiquinone metabolic process [GO:0006743]; vitamin E metabolic process [GO:0042360]; vitamin K metabolic process [GO:0042373]; xenobiotic metabolic process [GO:0006805] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; synapse [GO:0045202] | cytochrome-b5 reductase activity, acting on NAD(P)H [GO:0004128]; identical protein binding [GO:0042802]; NAD(P)H dehydrogenase (quinone) activity [GO:0003955]; NADH dehydrogenase (quinone) activity [GO:0050136]; NADPH dehydrogenase (quinone) activity [GO:0008753]; RNA binding [GO:0003723]; superoxide dismutase activity [GO:0004784] | 72506.4460307976 | 0.650682932436284 | 1.1246726201607E-7 | 2.07569871851156E-6 |
| O14530 | O14530 | TXND9_HUMAN | Thioredoxin domain-containing protein 9 (ATP-binding protein associated with cell differentiation) (Protein 1-4) | TXNDC9 | microtubule cytoskeleton organization [GO:0000226] | centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleus [GO:0005634] | cadherin binding [GO:0045296] | 17529.1237346391 | 0.716333783439536 | 1.28667069189298E-7 | 2.36697277281352E-6 |
| P23743 | P23743 | DGKA_HUMAN | Diacylglycerol kinase alpha (DAG kinase alpha) (EC 2.7.1.107) (EC 2.7.1.93) (80 kDa diacylglycerol kinase) (Diglyceride kinase alpha) (DGK-alpha) | DGKA | diacylglycerol metabolic process [GO:0046339]; glycerolipid metabolic process [GO:0046486]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; phosphatidic acid biosynthetic process [GO:0006654]; platelet activation [GO:0030168]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205] | cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886] | alkylglycerol kinase activity [GO:0047649]; ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; calcium ion binding [GO:0005509]; kinase activity [GO:0016301]; lipid binding [GO:0008289]; phospholipid binding [GO:0005543] | 9606.297260643074 | -0.525922602561951 | 1.29733736210613E-7 | 2.37119790119141E-6 |
| P36871 | P36871 | PGM1_HUMAN | Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) | PGM1 | carbohydrate metabolic process [GO:0005975]; gluconeogenesis [GO:0006094]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; tertiary granule lumen [GO:1904724] | magnesium ion binding [GO:0000287]; phosphoglucomutase activity [GO:0004614] | 97653.71983942244 | 0.114765483877277 | 1.2958006008053E-7 | 2.37119790119141E-6 |
| P09104 | P09104 | ENOG_HUMAN | Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE) | ENO2 | canonical glycolysis [GO:0061621]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; perikaryon [GO:0043204]; phosphopyruvate hydratase complex [GO:0000015]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886] | magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634] | 277105.9960168035 | 0.384446846323863 | 1.35119019584553E-7 | 2.46168606098416E-6 |
| P10809 | P10809 | CH60_HUMAN | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | HSPD1 | 'de novo' protein folding [GO:0006458]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic mitochondrial changes [GO:0008637]; B cell activation [GO:0042113]; B cell proliferation [GO:0042100]; biological process involved in interaction with symbiont [GO:0051702]; cellular response to interleukin-7 [GO:0098761]; chaperone-mediated protein complex assembly [GO:0051131]; isotype switching to IgG isotypes [GO:0048291]; mitochondrial unfolded protein response [GO:0034514]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage activation [GO:0043032]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell mediated immune response to tumor cell [GO:0002842]; positive regulation of type II interferon production [GO:0032729]; protein folding [GO:0006457]; protein import into mitochondrial intermembrane space [GO:0045041]; protein maturation [GO:0051604]; protein refolding [GO:0042026]; protein stabilization [GO:0050821]; response to cold [GO:0009409]; response to unfolded protein [GO:0006986]; T cell activation [GO:0042110] | cell surface [GO:0009986]; clathrin-coated pit [GO:0005905]; coated vesicle [GO:0030135]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lipopolysaccharide receptor complex [GO:0046696]; membrane [GO:0016020]; migrasome [GO:0140494]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; secretory granule [GO:0030141]; sperm midpiece [GO:0097225]; sperm plasma membrane [GO:0097524] | apolipoprotein A-I binding [GO:0034186]; apolipoprotein binding [GO:0034185]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; DNA replication origin binding [GO:0003688]; double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; high-density lipoprotein particle binding [GO:0008035]; isomerase activity [GO:0016853]; lipopolysaccharide binding [GO:0001530]; p53 binding [GO:0002039]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082] | 76834.31849596341 | 0.3183340344129 | 1.36765558752129E-7 | 2.48369761503065E-6 |
| P06756 | P06756 | ITAV_HUMAN | Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain] | ITGAV | angiogenesis [GO:0001525]; apolipoprotein A-I-mediated signaling pathway [GO:0038027]; apoptotic cell clearance [GO:0043277]; calcium ion transmembrane transport [GO:0070588]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; endodermal cell differentiation [GO:0035987]; entry into host cell by a symbiont-containing vacuole [GO:0085017]; ERK1 and ERK2 cascade [GO:0070371]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; negative chemotaxis [GO:0050919]; negative regulation of entry of bacterium into host cell [GO:2000536]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of lipid storage [GO:0010888]; negative regulation of lipid transport [GO:0032369]; negative regulation of lipoprotein metabolic process [GO:0050748]; negative regulation of low-density lipoprotein receptor activity [GO:1905598]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; regulation of phagocytosis [GO:0050764]; regulation of transforming growth factor beta activation [GO:1901388]; substrate adhesion-dependent cell spreading [GO:0034446]; symbiont entry into host cell [GO:0046718]; transforming growth factor beta production [GO:0071604]; vasculogenesis [GO:0001570]; wound healing, spreading of epidermal cells [GO:0035313] | alphav-beta3 integrin-HMGB1 complex [GO:0035868]; alphav-beta3 integrin-IGF-1-IGF1R complex [GO:0035867]; alphav-beta3 integrin-PKCalpha complex [GO:0035866]; cell surface [GO:0009986]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; filopodium membrane [GO:0031527]; focal adhesion [GO:0005925]; integrin alphav-beta1 complex [GO:0034682]; integrin alphav-beta3 complex [GO:0034683]; integrin alphav-beta5 complex [GO:0034684]; integrin alphav-beta6 complex [GO:0034685]; integrin alphav-beta8 complex [GO:0034686]; integrin complex [GO:0008305]; lamellipodium membrane [GO:0031258]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; specific granule membrane [GO:0035579] | coreceptor activity [GO:0015026]; extracellular matrix binding [GO:0050840]; extracellular matrix protein binding [GO:1990430]; fibronectin binding [GO:0001968]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; opsonin binding [GO:0001846]; protease binding [GO:0002020]; protein kinase C binding [GO:0005080]; transforming growth factor beta binding [GO:0050431]; virus receptor activity [GO:0001618]; voltage-gated calcium channel activity [GO:0005245] | 57688.5053783212 | -0.322612860369154 | 1.4078859307555E-7 | 2.54858839733567E-6 |
| O94760 | O94760 | DDAH1_HUMAN | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH-1) (Dimethylarginine dimethylaminohydrolase 1) (EC 3.5.3.18) (DDAHI) (Dimethylargininase-1) | DDAH1 | arginine catabolic process [GO:0006527]; arginine metabolic process [GO:0006525]; citrulline metabolic process [GO:0000052]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cellular response to hypoxia [GO:1900038]; negative regulation of vascular permeability [GO:0043116]; nitric oxide mediated signal transduction [GO:0007263]; nitric oxide metabolic process [GO:0046209]; positive regulation of angiogenesis [GO:0045766]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; regulation of systemic arterial blood pressure [GO:0003073] | cytosol [GO:0005829]; extracellular exosome [GO:0070062] | amino acid binding [GO:0016597]; catalytic activity [GO:0003824]; dimethylargininase activity [GO:0016403]; metal ion binding [GO:0046872] | 49035.6436342353 | 0.427862238173824 | 1.57867943262343E-7 | 2.84866167682941E-6 |
| P13807 | P13807 | GYS1_HUMAN | Glycogen [starch] synthase, muscle (EC 2.4.1.11) (Glycogen synthase 1) | GYS1 | glycogen biosynthetic process [GO:0005978]; heart development [GO:0007507] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; inclusion body [GO:0016234]; membrane [GO:0016020] | glucose binding [GO:0005536]; glycogen (starch) synthase activity [GO:0004373]; glycogen synthase activity, transferring glucose-1-phosphate [GO:0061547] | 48969.9609530643 | 0.313253239068742 | 1.59009523722399E-7 | 2.85110114370605E-6 |
| P12236 | P12236 | ADT3_HUMAN | ADP/ATP translocase 3 (ADP,ATP carrier protein 3) (ADP,ATP carrier protein, isoform T2) (ANT 2) (Adenine nucleotide translocator 3) (ANT 3) (Solute carrier family 25 member 6) [Cleaved into: ADP/ATP translocase 3, N-terminally processed] | SLC25A6 | apoptotic process [GO:0006915]; mitochondrial ADP transmembrane transport [GO:0140021]; mitochondrial ATP transmembrane transport [GO:1990544]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029] | membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744] | ATP:ADP antiporter activity [GO:0005471] | 33022.252732136156 | -0.680469756088776 | 1.58570690463196E-7 | 2.85110114370605E-6 |
| P08754 | P08754 | GNAI3_HUMAN | Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3) | GNAI3 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell cycle [GO:0007049]; cell division [GO:0051301]; dopamine receptor signaling pathway [GO:0007212]; GTP metabolic process [GO:0046039]; negative regulation of adenylate cyclase activity [GO:0007194]; positive regulation of macroautophagy [GO:0016239] | centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; heterotrimeric G-protein complex [GO:0005834]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] | G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] | 34057.6329470529 | 0.376890709637178 | 1.61041886841766E-7 | 2.87843322033264E-6 |
| Q15811 | Q15811 | ITSN1_HUMAN | Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17) | ITSN1 | clathrin-dependent synaptic vesicle endocytosis [GO:0150007]; endosomal transport [GO:0016197]; exocytosis [GO:0006887]; intracellular signal transduction [GO:0035556]; positive regulation of Rho protein signal transduction [GO:0035025]; protein localization [GO:0008104]; protein transport [GO:0015031]; regulation of small GTPase mediated signal transduction [GO:0051056] | clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular vesicle [GO:0097708]; lamellipodium [GO:0030027]; neuron projection [GO:0043005]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; recycling endosome [GO:0055037] | calcium ion binding [GO:0005509]; guanyl-nucleotide exchange factor activity [GO:0005085]; molecular adaptor activity [GO:0060090]; proline-rich region binding [GO:0070064] | 30076.5869817016 | 0.236470610694366 | 1.63412172367336E-7 | 2.90248704900728E-6 |
| Q8NCC3 | Q8NCC3 | PAG15_HUMAN | Lysosomal phospholipase A and acyltransferase (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (EC 3.1.1.5) (Lysophospholipase 3) (Lysosomal phospholipase A2) (LPLA2) (Phospholipase A2 group XV) (PLA2G15) | PLA2G15 | ceramide metabolic process [GO:0006672]; diacylglycerol biosynthetic process [GO:0006651]; fatty acid catabolic process [GO:0009062]; glycerophospholipid metabolic process [GO:0006650]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylethanolamine catabolic process [GO:0046338]; phosphatidylglycerol metabolic process [GO:0046471]; phosphatidylserine metabolic process [GO:0006658]; phospholipid metabolic process [GO:0006644] | extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleoplasm [GO:0005654] | 1-acyl-2-lysophosphatidylserine acylhydrolase activity [GO:0052740]; acylglycerol O-acyltransferase activity [GO:0016411]; calcium-independent phospholipase A2 activity [GO:0047499]; lysophospholipase activity [GO:0004622]; O-acyltransferase activity [GO:0008374]; phosphatidyl phospholipase B activity [GO:0102545]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipid binding [GO:0005543]; zinc ion binding [GO:0008270] | 24483.41095550915 | 0.56415607279957 | 1.63140624806208E-7 | 2.90248704900728E-6 |
| Q9NYU1 | Q9NYU1 | UGGG2_HUMAN | UDP-glucose:glycoprotein glucosyltransferase 2 (UGT2) (hUGT2) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase 2) (UDP-glucose ceramide glucosyltransferase-like 1) | UGGT2 | ERAD pathway [GO:0036503]; protein N-linked glycosylation via asparagine [GO:0018279] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; protein-containing complex [GO:0032991] | UDP-glucose:glycoprotein glucosyltransferase activity [GO:0003980]; unfolded protein binding [GO:0051082] | 12843.6106941744 | -0.21885041837903 | 1.6604553894426E-7 | 2.94004382393181E-6 |
| Q15067 | Q15067 | ACOX1_HUMAN | Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (Peroxisomal fatty acyl-CoA oxidase) (Straight-chain acyl-CoA oxidase) (SCOX) [Cleaved into: Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; Peroxisomal acyl-CoA oxidase 1, C chain] | ACOX1 | ascaroside biosynthetic process [GO:1904070]; cholesterol homeostasis [GO:0042632]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid catabolic process [GO:0009062]; fatty acid oxidation [GO:0019395]; generation of precursor metabolites and energy [GO:0006091]; hydrogen peroxide biosynthetic process [GO:0050665]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; long-chain fatty acid metabolic process [GO:0001676]; peroxisome fission [GO:0016559]; prostaglandin metabolic process [GO:0006693]; spermatogenesis [GO:0007283]; very long-chain fatty acid beta-oxidation [GO:0140493]; very long-chain fatty acid metabolic process [GO:0000038] | cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] | acyl-CoA oxidase activity [GO:0003997]; FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; flavin adenine dinucleotide binding [GO:0050660]; palmitoyl-CoA oxidase activity [GO:0016401]; PDZ domain binding [GO:0030165]; protein homodimerization activity [GO:0042803] | 15509.9129540858 | -0.40559147281359 | 1.74279624654803E-7 | 3.07020584722145E-6 |
| P52630 | P52630 | STAT2_HUMAN | Signal transducer and activator of transcription 2 (p113) | STAT2 | defense response [GO:0006952]; defense response to virus [GO:0051607]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of cell population proliferation [GO:0042127]; regulation of mitochondrial fission [GO:0090140]; regulation of protein phosphorylation [GO:0001932]; regulation of transcription by RNA polymerase II [GO:0006357]; response to peptide hormone [GO:0043434]; type I interferon-mediated signaling pathway [GO:0060337] | chromatin [GO:0000785]; cytosol [GO:0005829]; ISGF3 complex [GO:0070721]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575] | DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; ubiquitin-like protein ligase binding [GO:0044389] | 10351.32397714385 | -0.504562477616834 | 1.74480459372628E-7 | 3.07020584722145E-6 |
| P51911 | P51911 | CNN1_HUMAN | Calponin-1 (Basic calponin) (Calponin H1, smooth muscle) | CNN1 | actin filament organization [GO:0007015]; actomyosin structure organization [GO:0031032]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; regulation of smooth muscle contraction [GO:0006940] | actin cytoskeleton [GO:0015629]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925] | actin filament binding [GO:0051015]; calmodulin binding [GO:0005516] | 17464.471629378248 | -1.37151089709488 | 1.88735527205182E-7 | 3.31076005307913E-6 |
| Q8NI08 | Q8NI08 | NCOA7_HUMAN | Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) | NCOA7 | negative regulation of cellular response to oxidative stress [GO:1900408]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to oxidative stress [GO:0006979] | nucleus [GO:0005634] | nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374] | 6897.210267188295 | -0.476141461812233 | 2.09296609840991E-7 | 3.66010676345387E-6 |
| Q9BXJ1 | Q9BXJ1 | C1QT1_HUMAN | Complement C1q tumor necrosis factor-related protein 1 (G protein-coupled receptor-interacting protein) (GIP) | C1QTNF1 | negative regulation of platelet activation [GO:0010544]; negative regulation of platelet aggregation [GO:0090331]; positive regulation of aldosterone secretion [GO:2000860]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of glucose metabolic process [GO:0010906] | collagen trimer [GO:0005581]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] | collagen binding [GO:0005518]; identical protein binding [GO:0042802] | 55319.5667243323 | 0.653333670995073 | 2.28979748917496E-7 | 3.99199771497395E-6 |
| P28070 | P28070 | PSB4_HUMAN | Proteasome subunit beta type-4 (26 kDa prosomal protein) (HsBPROS26) (PROS-26) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (HsN3) | PSMB4 | negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] | ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774] | lipopolysaccharide binding [GO:0001530] | 80814.7551921173 | -0.870538472498977 | 2.36491027032054E-7 | 4.11030110172888E-6 |
| Q15293 | Q15293 | RCN1_HUMAN | Reticulocalbin-1 | RCN1 | camera-type eye development [GO:0043010]; in utero embryonic development [GO:0001701] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788] | calcium ion binding [GO:0005509] | 355155.940605805 | 0.49434790830304 | 2.3882152003159E-7 | 4.1381123318012E-6 |
| P51149 | P51149 | RAB7A_HUMAN | Ras-related protein Rab-7a (EC 3.6.5.2) | RAB7A | autophagosome assembly [GO:0000045]; bone resorption [GO:0045453]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; endosome to lysosome transport [GO:0008333]; endosome to plasma membrane protein transport [GO:0099638]; epidermal growth factor catabolic process [GO:0007174]; establishment of vesicle localization [GO:0051650]; intracellular transport [GO:0046907]; lipid catabolic process [GO:0016042]; lipophagy [GO:0061724]; negative regulation of exosomal secretion [GO:1903542]; negative regulation of intralumenal vesicle formation [GO:1905366]; phagosome acidification [GO:0090383]; phagosome maturation [GO:0090382]; phagosome-lysosome fusion [GO:0090385]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of viral process [GO:0048524]; protein targeting to lysosome [GO:0006622]; protein to membrane docking [GO:0022615]; protein transport [GO:0015031]; response to bacterium [GO:0009617]; retrograde transport, endosome to Golgi [GO:0042147]; viral release from host cell [GO:0019076] | alveolar lamellar body [GO:0097208]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome membrane [GO:0033162]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; phagophore assembly site membrane [GO:0034045]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672] | G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; retromer complex binding [GO:1905394]; small GTPase binding [GO:0031267] | 251524.42499027652 | -0.470189900497328 | 2.43122079612626E-7 | 4.19978568013761E-6 |
| O00154 | O00154 | BACH_HUMAN | Cytosolic acyl coenzyme A thioester hydrolase (EC 3.1.2.2) (Acyl-CoA thioesterase 7) (Brain acyl-CoA hydrolase) (BACH) (hBACH) (CTE-IIa) (CTE-II) (Long chain acyl-CoA thioester hydrolase) | ACOT7 | acyl-CoA metabolic process [GO:0006637]; coenzyme A biosynthetic process [GO:0015937]; fatty acid catabolic process [GO:0009062]; long-chain fatty-acyl-CoA catabolic process [GO:0036116]; medium-chain fatty acid biosynthetic process [GO:0051792]; medium-chain fatty-acyl-CoA catabolic process [GO:0036114]; palmitic acid biosynthetic process [GO:1900535] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] | carboxylic ester hydrolase activity [GO:0052689]; fatty-acyl-CoA binding [GO:0000062]; long-chain fatty acyl-CoA binding [GO:0036042]; long-chain fatty acyl-CoA hydrolase activity [GO:0052816]; protein homodimerization activity [GO:0042803] | 139505.0898827285 | 0.173961085969463 | 2.54525807602273E-7 | 4.38341406040876E-6 |
| P17936 | P17936 | IBP3_HUMAN | Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3) | IGFBP3 | apoptotic process [GO:0006915]; MAPK cascade [GO:0000165]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of signal transduction [GO:0009968]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of smooth muscle cell proliferation [GO:0048662]; osteoblast differentiation [GO:0001649]; positive regulation of apoptotic process [GO:0043065]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of myoblast differentiation [GO:0045663]; protein phosphorylation [GO:0006468]; regulation of cell growth [GO:0001558]; regulation of glucose metabolic process [GO:0010906]; regulation of insulin-like growth factor receptor signaling pathway [GO:0043567]; type B pancreatic cell proliferation [GO:0044342] | endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; insulin-like growth factor binding protein complex [GO:0016942]; insulin-like growth factor ternary complex [GO:0042567]; nucleus [GO:0005634] | fibronectin binding [GO:0001968]; insulin-like growth factor binding [GO:0005520]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]; metal ion binding [GO:0046872]; protein tyrosine phosphatase activator activity [GO:0008160] | 73748.0366289358 | 0.669236694505018 | 2.66246095902201E-7 | 4.57136478600567E-6 |
| P12109 | P12109 | CO6A1_HUMAN | Collagen alpha-1(VI) chain | COL6A1 | 2-oxoglutarate metabolic process [GO:0006103]; adipose tissue development [GO:0060612]; apoptotic nuclear changes [GO:0030262]; autophagy [GO:0006914]; basement membrane organization [GO:0071711]; bone development [GO:0060348]; bone mineralization [GO:0030282]; canonical Wnt signaling pathway [GO:0060070]; cartilage development [GO:0051216]; caveola assembly [GO:0070836]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cellular response to amino acid stimulus [GO:0071230]; circadian rhythm [GO:0007623]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; endodermal cell differentiation [GO:0035987]; energy reserve metabolic process [GO:0006112]; extracellular matrix assembly [GO:0085029]; fat cell proliferation [GO:0070341]; gene expression [GO:0010467]; glycolytic process [GO:0006096]; hair follicle development [GO:0001942]; heart development [GO:0007507]; homeostasis of number of cells [GO:0048872]; inflammatory response [GO:0006954]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; limb joint morphogenesis [GO:0036022]; lung alveolus development [GO:0048286]; lung epithelial cell differentiation [GO:0060487]; lung morphogenesis [GO:0060425]; mitochondrial depolarization [GO:0051882]; mitochondrial transmembrane transport [GO:1990542]; mitochondrion organization [GO:0007005]; multicellular organismal locomotion [GO:0071965]; muscle cell apoptotic process [GO:0010657]; muscle system process [GO:0003012]; myelination in peripheral nervous system [GO:0022011]; neuron apoptotic process [GO:0051402]; osteoblast differentiation [GO:0001649]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; protein tetramerization [GO:0051262]; reactive oxygen species metabolic process [GO:0072593]; reduction of food intake in response to dietary excess [GO:0002023]; regulation of cell size [GO:0008361]; regulation of collagen fibril organization [GO:1904026]; respiratory system process [GO:0003016]; response to bleomycin [GO:1904975]; response to decreased oxygen levels [GO:0036293]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to muscle activity [GO:0014850]; response to pain [GO:0048265]; response to polyamine macromolecule [GO:1904583]; response to reactive oxygen species [GO:0000302]; response to toxic substance [GO:0009636]; response to UV [GO:0009411]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; sensory perception of mechanical stimulus [GO:0050954]; single fertilization [GO:0007338]; skeletal muscle fiber development [GO:0048741]; skeletal muscle fiber differentiation [GO:0098528]; skeletal muscle tissue growth [GO:0048630]; skeletal muscle tissue regeneration [GO:0043403]; tissue remodeling [GO:0048771]; transmission of nerve impulse [GO:0019226]; tricarboxylic acid cycle [GO:0006099]; uterus development [GO:0060065] | basement membrane [GO:0005604]; collagen type VI trimer [GO:0005589]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intracellular vesicle [GO:0097708]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrion [GO:0005739]; myofibril [GO:0030016]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529] | collagen binding [GO:0005518]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; platelet-derived growth factor binding [GO:0048407] | 52342.3380830593 | 0.270818104268168 | 2.7653418214949E-7 | 4.73366367389429E-6 |
| O43166 | O43166 | SI1L1_HUMAN | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | SIPA1L1 | actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; ephrin receptor signaling pathway [GO:0048013]; regulation of axonogenesis [GO:0050770]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; regulation of synaptic plasticity [GO:0048167] | actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] | ephrin receptor binding [GO:0046875]; GTPase activator activity [GO:0005096] | 8756.483649809215 | -0.516078469463514 | 2.84569391549924E-7 | 4.8565366642225E-6 |
| P28062 | P28062 | PSB8_HUMAN | Proteasome subunit beta type-8 (EC 3.4.25.1) (Low molecular mass protein 7) (Macropain subunit C13) (Multicatalytic endopeptidase complex subunit C13) (Proteasome component C13) (Proteasome subunit beta-5i) (Really interesting new gene 10 protein) | PSMB8 | antigen processing and presentation [GO:0019882]; fat cell differentiation [GO:0045444]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of endopeptidase activity [GO:0052548] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]; spermatoproteasome complex [GO:1990111] | endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298] | 28648.4681397575 | 0.839819425848681 | 2.95700771853276E-7 | 5.03135307303502E-6 |
| P53680 | P53680 | AP2S1_HUMAN | AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin) | AP2S1 | clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; regulation of endocytosis [GO:0030100]; synaptic vesicle endocytosis [GO:0048488]; vesicle-mediated transport [GO:0016192] | AP-2 adaptor complex [GO:0030122]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endolysosome membrane [GO:0036020]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793] | clathrin adaptor activity [GO:0035615] | 38825.754776119255 | -0.972458020129816 | 2.98129557717482E-7 | 5.05749123960255E-6 |
| Q9NSD9 | Q9NSD9 | SYFB_HUMAN | Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS) | FARSB | phenylalanyl-tRNA aminoacylation [GO:0006432]; protein heterotetramerization [GO:0051290]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; phenylalanine-tRNA ligase complex [GO:0009328] | ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; phenylalanine-tRNA ligase activity [GO:0004826]; RNA binding [GO:0003723] | 45374.62175455025 | -0.228861840654654 | 3.04285926374612E-7 | 5.14651957862254E-6 |
| P35610 | P35610 | SOAT1_HUMAN | Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1) | SOAT1 | cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol storage [GO:0010878]; low-density lipoprotein particle clearance [GO:0034383]; macrophage derived foam cell differentiation [GO:0010742]; positive regulation of amyloid precursor protein biosynthetic process [GO:0042986]; very-low-density lipoprotein particle assembly [GO:0034379] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] | cholesterol binding [GO:0015485]; cholesterol O-acyltransferase activity [GO:0034736]; fatty-acyl-CoA binding [GO:0000062]; identical protein binding [GO:0042802]; sterol O-acyltransferase activity [GO:0004772] | 8553.12039166183 | 0.445166996782974 | 3.12378787587666E-7 | 5.26767324545154E-6 |
| O15260 | O15260 | SURF4_HUMAN | Surfeit locus protein 4 | SURF4 | COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; lipid export from cell [GO:0140353]; lipid homeostasis [GO:0055088]; lipoprotein transport [GO:0042953]; positive regulation of organelle organization [GO:0010638]; regulation of lipid transport [GO:0032368] | azurophil granule membrane [GO:0035577]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133] | cargo receptor activity [GO:0038024]; COPII receptor activity [GO:0097020] | 63092.9650835339 | -1.08135471852413 | 3.39181050175852E-7 | 5.70267011957382E-6 |
| Q01432 | Q01432 | AMPD3_HUMAN | AMP deaminase 3 (EC 3.5.4.6) (AMP deaminase isoform E) (Erythrocyte AMP deaminase) | AMPD3 | AMP catabolic process [GO:0006196]; AMP metabolic process [GO:0046033]; IMP biosynthetic process [GO:0006188]; IMP salvage [GO:0032264] | cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774] | AMP deaminase activity [GO:0003876]; metal ion binding [GO:0046872] | 6077.954320148205 | 0.980840013892252 | 3.47117551981449E-7 | 5.81884038321565E-6 |
| P48147 | P48147 | PPCE_HUMAN | Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme) | PREP | proteolysis [GO:0006508] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634] | oligopeptidase activity [GO:0070012]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] | 20266.5872679498 | -0.252893995437057 | 3.57655967637324E-7 | 5.977813311602E-6 |
| Q00796 | Q00796 | DHSO_HUMAN | Sorbitol dehydrogenase (SDH) (EC 1.1.1.-) ((R,R)-butanediol dehydrogenase) (EC 1.1.1.4) (L-iditol 2-dehydrogenase) (EC 1.1.1.14) (Polyol dehydrogenase) (Ribitol dehydrogenase) (RDH) (EC 1.1.1.56) (Xylitol dehydrogenase) (XDH) (EC 1.1.1.9) | SORD | flagellated sperm motility [GO:0030317]; fructose biosynthetic process [GO:0046370]; glucose metabolic process [GO:0006006]; glucuronate catabolic process to xylulose 5-phosphate [GO:0019640]; L-xylitol catabolic process [GO:0051160]; L-xylitol metabolic process [GO:0051164]; sorbitol catabolic process [GO:0006062] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; motile cilium [GO:0031514] | (R,R)-butanediol dehydrogenase activity [GO:0000721]; carbohydrate binding [GO:0030246]; D-sorbitol dehydrogenase (acceptor) activity [GO:0047833]; D-xylulose reductase activity [GO:0046526]; identical protein binding [GO:0042802]; L-iditol 2-dehydrogenase activity [GO:0003939]; NAD binding [GO:0051287]; ribitol 2-dehydrogenase activity [GO:0050255]; zinc ion binding [GO:0008270] | 23909.424704367848 | 0.435176046997946 | 3.63472250587095E-7 | 6.05715815243083E-6 |
| Q9UHD2 | Q9UHD2 | TBK1_HUMAN | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) | TBK1 | activation of innate immune response [GO:0002218]; antiviral innate immune response [GO:0140374]; canonical NF-kappaB signal transduction [GO:0007249]; cGAS/STING signaling pathway [GO:0140896]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; dendritic cell proliferation [GO:0044565]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of gene expression [GO:0010629]; negative regulation of TORC1 signaling [GO:1904262]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of macroautophagy [GO:0016239]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; positive regulation of xenophagy [GO:1904417]; protein phosphorylation [GO:0006468]; regulation of type I interferon production [GO:0032479]; response to virus [GO:0009615]; toll-like receptor 4 signaling pathway [GO:0034142]; type I interferon-mediated signaling pathway [GO:0060337] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; serine/threonine protein kinase complex [GO:1902554] | ATP binding [GO:0005524]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; phosphoprotein binding [GO:0051219]; protein kinase activity [GO:0004672]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | 5091.109606763444 | -1.28082671628842 | 3.76296124731946E-7 | 6.25247461211498E-6 |
| P14317 | P14317 | HCLS1_HUMAN | Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75) | HCLS1 | actin filament organization [GO:0007015]; cellular response to cytokine stimulus [GO:0071345]; erythrocyte differentiation [GO:0030218]; granulocyte colony-stimulating factor signaling pathway [GO:0038158]; intracellular signal transduction [GO:0035556]; negative regulation of leukocyte apoptotic process [GO:2000107]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear transport [GO:0051169]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of actin filament polymerization [GO:0030833]; regulation of DNA-templated transcription [GO:0006355]; response to hormone [GO:0009725]; signal transduction [GO:0007165] | actin filament [GO:0005884]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; site of polarized growth [GO:0030427]; transcription regulator complex [GO:0005667] | actin filament binding [GO:0051015]; protein kinase binding [GO:0019901]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591] | 18951.46019083775 | 0.705934870233491 | 3.78149871249302E-7 | 6.26490400730568E-6 |
| O95865 | O95865 | DDAH2_HUMAN | Putative hydrolase DDAH2 (EC 3.-.-.-) (DDAHII) (Inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2) (DDAH-2) (Inactive dimethylarginine dimethylaminohydrolase 2) (Protein G6a) (S-phase protein) | DDAH2 | arginine metabolic process [GO:0006525]; negative regulation of apoptotic process [GO:0043066]; positive regulation of nitric oxide biosynthetic process [GO:0045429] | extracellular exosome [GO:0070062]; mitochondrion [GO:0005739] | amino acid binding [GO:0016597]; hydrolase activity [GO:0016787] | 14375.91307681275 | -1.08472031653062 | 3.82803747192396E-7 | 6.32164213583415E-6 |
| Q8N0X7 | Q8N0X7 | SPART_HUMAN | Spartin (Spastic paraplegia 20 protein) (Trans-activated by hepatitis C virus core protein 1) | SPART | abscission [GO:0009838]; adipose tissue development [GO:0060612]; BMP signaling pathway [GO:0030509]; cell division [GO:0051301]; collateral sprouting in absence of injury [GO:0048669]; lipid droplet organization [GO:0034389]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of collateral sprouting in absence of injury [GO:0048698]; neuromuscular process [GO:0050905]; regulation of mitochondrial membrane potential [GO:0051881] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; midbody [GO:0030496]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]; synapse [GO:0045202] | ubiquitin protein ligase binding [GO:0031625] | 20070.16618268635 | 0.33928336003508 | 3.83806017424452E-7 | 6.32164213583415E-6 |
| O43396 | O43396 | TXNL1_HUMAN | Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein) | TXNL1 | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; proteasome complex [GO:0000502] | disulfide oxidoreductase activity [GO:0015036]; protein-disulfide reductase activity [GO:0015035] | 61130.9397717974 | 0.397356156439438 | 4.41870042903531E-7 | 7.25691496548234E-6 | |
| P06744 | P06744 | G6PI_HUMAN | Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Sperm antigen 36) (SA-36) | GPI | carbohydrate metabolic process [GO:0005975]; erythrocyte homeostasis [GO:0034101]; gluconeogenesis [GO:0006094]; glucose 6-phosphate metabolic process [GO:0051156]; glucose homeostasis [GO:0042593]; glycolytic process [GO:0006096]; hemostasis [GO:0007599]; humoral immune response [GO:0006959]; in utero embryonic development [GO:0001701]; learning or memory [GO:0007611]; mesoderm formation [GO:0001707]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of immunoglobulin production [GO:0002639]; response to cadmium ion [GO:0046686]; response to estradiol [GO:0032355]; response to immobilization stress [GO:0035902]; response to muscle stretch [GO:0035994]; response to progesterone [GO:0032570]; response to testosterone [GO:0033574] | ciliary membrane [GO:0060170]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; secretory granule lumen [GO:0034774] | carbohydrate derivative binding [GO:0097367]; cytokine activity [GO:0005125]; glucose-6-phosphate isomerase activity [GO:0004347]; growth factor activity [GO:0008083]; monosaccharide binding [GO:0048029]; ubiquitin protein ligase binding [GO:0031625] | 248832.408885087 | 0.248292627558022 | 4.74790290097755E-7 | 7.77503405691873E-6 |
| P20073 | P20073 | ANXA7_HUMAN | Annexin A7 (Annexin VII) (Annexin-7) (Synexin) | ANXA7 | autophagy [GO:0006914]; epithelial cell differentiation [GO:0030855]; negative regulation of gene expression [GO:0010629] | collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | 1-phosphatidylinositol binding [GO:0005545]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; phosphatidylethanolamine binding [GO:0008429]; phosphatidylserine binding [GO:0001786]; RNA binding [GO:0003723] | 124051.53737032949 | 0.269398816314787 | 5.14001350920319E-7 | 8.39288661185743E-6 |
| Q14019 | Q14019 | COTL1_HUMAN | Coactosin-like protein | COTL1 | defense response to fungus [GO:0050832]; regulation of actin filament polymerization [GO:0030833] | actin filament [GO:0005884]; cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; site of polarized growth [GO:0030427] | actin binding [GO:0003779]; actin filament binding [GO:0051015]; enzyme binding [GO:0019899] | 385717.308740745 | 0.518421576571888 | 5.25485561077004E-7 | 8.55575054328248E-6 |
| P84085 | P84085 | ARF5_HUMAN | ADP-ribosylation factor 5 | ARF5 | intracellular protein transport [GO:0006886]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle-mediated transport [GO:0016192] | extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] | GTP binding [GO:0005525]; GTPase activity [GO:0003924] | 45254.61716263755 | -0.968927065639052 | 5.36924378920705E-7 | 8.71694421479861E-6 |
| Q16832 | Q16832 | DDR2_HUMAN | Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b) | DDR2 | biomineral tissue development [GO:0031214]; cell adhesion [GO:0007155]; cellular response to angiotensin [GO:1904385]; cellular response to hypoxia [GO:0071456]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chondrocyte proliferation [GO:0035988]; collagen fibril organization [GO:0030199]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; endochondral bone growth [GO:0003416]; negative regulation of apoptotic process [GO:0043066]; negative regulation of hydrogen peroxide-mediated programmed cell death [GO:1901299]; ossification [GO:0001503]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of hepatic stellate cell activation [GO:2000491]; positive regulation of hepatic stellate cell proliferation [GO:1904899]; positive regulation of neuron projection development [GO:0010976]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of wound healing [GO:0090303]; protein autophosphorylation [GO:0046777]; regulation of bone mineralization [GO:0030500]; regulation of extracellular matrix disassembly [GO:0010715]; regulation of tissue remodeling [GO:0034103]; response to muscle stretch [GO:0035994]; signal transduction [GO:0007165] | actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] | ATP binding [GO:0005524]; collagen binding [GO:0005518]; protein tyrosine kinase collagen receptor activity [GO:0038062]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] | 13209.32009829255 | -0.550036455723906 | 5.61654994199851E-7 | 9.09239199181816E-6 |
| Q9Y3D6 | Q9Y3D6 | FIS1_HUMAN | Mitochondrial fission 1 protein (FIS1 homolog) (hFis1) (Tetratricopeptide repeat protein 11) (TPR repeat protein 11) | FIS1 | autophagy of mitochondrion [GO:0000422]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; mitochondrial fission [GO:0000266]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial fusion [GO:0008053]; mitochondrion organization [GO:0007005]; negative regulation of ATP metabolic process [GO:1903579]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; negative regulation of fatty acid transport [GO:2000192]; peroxisome fission [GO:0016559]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein targeting to membrane [GO:0090314]; protein targeting to mitochondrion [GO:0006626]; regulation of mitochondrion organization [GO:0010821]; release of cytochrome c from mitochondria [GO:0001836] | cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991] | identical protein binding [GO:0042802]; lipid binding [GO:0008289]; molecular adaptor activity [GO:0060090] | 17630.8650204995 | -1.29205490819702 | 6.14032520576652E-7 | 9.9119893492516E-6 |
| P15374 | P15374 | UCHL3_HUMAN | Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) (EC 3.4.19.12) (Ubiquitin thioesterase L3) | UCHL3 | post-translational protein modification [GO:0043687]; protein catabolic process [GO:0030163]; protein deubiquitination [GO:0016579]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] | cysteine-type deubiquitinase activity [GO:0004843]; deNEDDylase activity [GO:0019784]; peptidase activity [GO:0008233]; ubiquitin binding [GO:0043130] | 70240.3710102749 | 0.308323319613559 | 6.21290989683314E-7 | 1.00006668964365E-5 |
| Q13363 | Q13363 | CTBP1_HUMAN | C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-) | CTBP1 | negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]; synaptic vesicle clustering [GO:0097091]; synaptic vesicle endocytosis [GO:0048488]; viral genome replication [GO:0019079]; white fat cell differentiation [GO:0050872] | GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; presynaptic active zone cytoplasmic component [GO:0098831]; transcription repressor complex [GO:0017053] | chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; protein domain specific binding [GO:0019904]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transcription coregulator binding [GO:0001221]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222] | 21252.1416868613 | -0.260211837203306 | 6.36252958280853E-7 | 1.0212490826117E-5 |
| O94851 | O94851 | MICA2_HUMAN | [F-actin]-monooxygenase MICAL2 (EC 1.14.13.225) (MICAL C-terminal-like protein) (Mical-cL) (Molecule interacting with CasL protein 2) (MICAL-2) | MICAL2 | actin filament depolymerization [GO:0030042]; cytoskeleton organization [GO:0007010]; heart development [GO:0007507]; heart looping [GO:0001947]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sulfur oxidation [GO:0019417] | actin filament [GO:0005884]; cytoplasm [GO:0005737]; nucleus [GO:0005634] | actin binding [GO:0003779]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; mitogen-activated protein kinase binding [GO:0051019]; monooxygenase activity [GO:0004497]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709] | 15732.5551395525 | -0.448761843834449 | 6.62501468634544E-7 | 1.06037664443032E-5 |
| O00423 | O00423 | EMAL1_HUMAN | Echinoderm microtubule-associated protein-like 1 (EMAP-1) (HuEMAP-1) | EML1 | brain development [GO:0007420]; hematopoietic progenitor cell differentiation [GO:0002244]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; neuroblast proliferation [GO:0007405] | cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]; perinuclear region of cytoplasm [GO:0048471] | calcium ion binding [GO:0005509]; microtubule binding [GO:0008017]; tubulin binding [GO:0015631] | 13565.6867847984 | 0.726314198875477 | 6.87638502059605E-7 | 1.09750978948443E-5 |
| Q02978 | Q02978 | M2OM_HUMAN | Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (alpha-oxoglutarate carrier) (Solute carrier family 25 member 11) (SLC25A11) | SLC25A11 | gluconeogenesis [GO:0006094]; lipid transport [GO:0006869]; malate transmembrane transport [GO:0071423]; oxaloacetate transport [GO:0015729]; phosphate ion transmembrane transport [GO:0035435]; succinate transmembrane transport [GO:0071422]; sulfate transport [GO:0008272]; thiosulfate transport [GO:0015709] | mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | antiporter activity [GO:0015297]; malate transmembrane transporter activity [GO:0015140]; oxaloacetate transmembrane transporter activity [GO:0015131]; oxoglutarate:malate antiporter activity [GO:0015367]; RNA binding [GO:0003723]; succinate transmembrane transporter activity [GO:0015141]; sulfate transmembrane transporter activity [GO:0015116]; thiosulfate transmembrane transporter activity [GO:0015117] | 14351.3804759091 | -1.74478081626019 | 6.97498070195349E-7 | 1.11011911958619E-5 |
| Q7Z4F1 | Q7Z4F1 | LRP10_HUMAN | Low-density lipoprotein receptor-related protein 10 (LRP-10) | LRP10 | endocytosis [GO:0006897]; inner ear development [GO:0048839]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869] | clathrin-coated pit [GO:0005905]; membrane [GO:0016020]; plasma membrane [GO:0005886] | low-density lipoprotein particle receptor activity [GO:0005041] | 29558.0312768525 | -0.418581903867443 | 7.2668229161164E-7 | 1.15090187978612E-5 |
| P54577 | P54577 | SYYC_HUMAN | Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) [Cleaved into: Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed] | YARS1 | apoptotic process [GO:0006915]; response to starvation [GO:0042594]; tyrosyl-tRNA aminoacylation [GO:0006437] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; methionyl glutamyl tRNA synthetase complex [GO:0017102]; nuclear body [GO:0016604]; nucleus [GO:0005634] | ATP binding [GO:0005524]; interleukin-8 receptor binding [GO:0005153]; RNA binding [GO:0003723]; small molecule binding [GO:0036094]; tRNA binding [GO:0000049]; tyrosine-tRNA ligase activity [GO:0004831] | 82282.19630804891 | -0.152286016517038 | 7.27184738728261E-7 | 1.15090187978612E-5 |
| Q8TDZ2 | Q8TDZ2 | MICA1_HUMAN | [F-actin]-monooxygenase MICAL1 (EC 1.14.13.225) (EC 1.6.3.1) (Molecule interacting with CasL protein 1) (MICAL-1) (NEDD9-interacting protein with calponin homology and LIM domains) | MICAL1 | actin filament bundle assembly [GO:0051017]; actin filament depolymerization [GO:0030042]; cytoskeleton organization [GO:0007010]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein phosphorylation [GO:0001933]; regulation of regulated secretory pathway [GO:1903305]; signal transduction [GO:0007165]; sulfur oxidation [GO:0019417] | actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; hippocampal mossy fiber expansion [GO:1990026]; intercellular bridge [GO:0045171]; intermediate filament [GO:0005882]; midbody [GO:0030496]; plasma membrane [GO:0005886] | actin binding [GO:0003779]; actin filament binding [GO:0051015]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; monooxygenase activity [GO:0004497]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; NADPH oxidase H202-forming activity [GO:0106294]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267] | 9146.843723608756 | -0.719143128745354 | 7.35437343298277E-7 | 1.15749666309112E-5 |
| O96011 | O96011 | PX11B_HUMAN | Peroxisomal membrane protein 11B (Peroxin-11B) (Peroxisomal biogenesis factor 11B) (Protein PEX11 homolog beta) (PEX11-beta) | PEX11B | peroxisome fission [GO:0016559]; peroxisome organization [GO:0007031]; regulation of peroxisome size [GO:0044375]; signal transduction [GO:0007165] | cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991] | identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] | 6574.529497932344 | -1.91206061317927 | 7.35276288093895E-7 | 1.15749666309112E-5 |
| P80162 | P80162 | CXCL6_HUMAN | C-X-C motif chemokine 6 (Chemokine alpha 3) (CKA-3) (Granulocyte chemotactic protein 2) (GCP-2) (Small-inducible cytokine B6) [Cleaved into: Small-inducible cytokine B6, N-processed variant 1; Small-inducible cytokine B6, N-processed variant 2; Small-inducible cytokine B6, N-processed variant 3] | CXCL6 | antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell-cell signaling [GO:0007267]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; defense response to bacterium [GO:0042742]; inflammatory response [GO:0006954]; leukocyte homeostasis [GO:0001776]; neutrophil activation [GO:0042119]; neutrophil chemotaxis [GO:0030593]; regulation of chemokine production [GO:0032642]; regulation of neutrophil mediated killing of gram-negative bacterium [GO:0070951]; signal transduction [GO:0007165] | extracellular region [GO:0005576]; extracellular space [GO:0005615] | chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; heparin binding [GO:0008201] | 15239.638478097488 | 2.4476250279301 | 8.14011302239358E-7 | 1.27761441509369E-5 |
| Q99497 | Q99497 | PARK7_HUMAN | Parkinson disease protein 7 (Maillard deglycase) (Oncogene DJ1) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1) (Protein/nucleic acid deglycase DJ-1) (EC 3.1.2.-, EC 3.5.1.-, EC 3.5.1.124) | PARK7 | activation of protein kinase B activity [GO:0032148]; adult locomotory behavior [GO:0008344]; autophagy [GO:0006914]; cellular detoxification of aldehyde [GO:0110095]; cellular detoxification of methylglyoxal [GO:0140041]; cellular response to glyoxal [GO:0036471]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to oxidative stress [GO:0034599]; detection of oxidative stress [GO:0070994]; detoxification of copper ion [GO:0010273]; detoxification of hydrogen peroxide [GO:0061691]; detoxification of mercury ion [GO:0050787]; DNA repair [GO:0006281]; dopamine uptake involved in synaptic transmission [GO:0051583]; glucose homeostasis [GO:0042593]; glutathione deglycation [GO:0036531]; glycolate biosynthetic process [GO:0046295]; glyoxal metabolic process [GO:1903189]; guanine deglycation [GO:0106044]; guanine deglycation, glyoxal removal [GO:0106046]; guanine deglycation, methylglyoxal removal [GO:0106045]; hydrogen peroxide metabolic process [GO:0042743]; inflammatory response [GO:0006954]; insulin secretion [GO:0030073]; lactate biosynthetic process [GO:0019249]; membrane depolarization [GO:0051899]; membrane hyperpolarization [GO:0060081]; methylglyoxal catabolic process to lactate [GO:0061727]; methylglyoxal metabolic process [GO:0009438]; mitochondrion organization [GO:0007005]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001268]; negative regulation of death-inducing signaling complex assembly [GO:1903073]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of gene expression [GO:0010629]; negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway [GO:1903384]; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:1903751]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway [GO:1905259]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein acetylation [GO:1901984]; negative regulation of protein binding [GO:0032091]; negative regulation of protein export from nucleus [GO:0046826]; negative regulation of protein K48-linked deubiquitination [GO:1903094]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; negative regulation of TRAIL-activated apoptotic signaling pathway [GO:1903122]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; negative regulation of ubiquitin-specific protease activity [GO:2000157]; peptidyl-arginine deglycation [GO:0036527]; peptidyl-cysteine deglycation [GO:0036526]; peptidyl-lysine deglycation [GO:0036528]; positive regulation of acute inflammatory response to antigenic stimulus [GO:0002866]; positive regulation of androgen receptor activity [GO:2000825]; positive regulation of autophagy of mitochondrion [GO:1903599]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of dopamine biosynthetic process [GO:1903181]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of L-dopa biosynthetic process [GO:1903197]; positive regulation of L-dopa decarboxylase activity [GO:1903200]; positive regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902958]; positive regulation of NAD(P)H oxidase activity [GO:0033864]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of pyrroline-5-carboxylate reductase activity [GO:1903168]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of superoxide dismutase activity [GO:1901671]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of tyrosine 3-monooxygenase activity [GO:1903178]; protein deglycation, glyoxal removal [GO:0036529]; protein deglycation, methylglyoxal removal [GO:0036530]; protein deglycosylation [GO:0006517]; protein stabilization [GO:0050821]; proteolysis [GO:0006508]; Ras protein signal transduction [GO:0007265]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of inflammatory response [GO:0050727]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of neuron apoptotic process [GO:0043523]; regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903376]; regulation of supramolecular fiber organization [GO:1902903]; response to oxidative stress [GO:0006979]; single fertilization [GO:0007338] | adherens junction [GO:0005912]; axon [GO:0030424]; cell body [GO:0044297]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; PML body [GO:0016605]; presynapse [GO:0098793] | cadherin binding [GO:0045296]; copper ion binding [GO:0005507]; cupric ion binding [GO:1903135]; cuprous ion binding [GO:1903136]; cytokine binding [GO:0019955]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; glyoxalase (glycolic acid-forming) activity [GO:1990422]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; L-dopa decarboxylase activator activity [GO:0036478]; mercury ion binding [GO:0045340]; mRNA binding [GO:0003729]; nuclear androgen receptor binding [GO:0050681]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]; oxygen sensor activity [GO:0019826]; peptidase activity [GO:0008233]; peroxiredoxin activity [GO:0051920]; protein deglycase activity [GO:0036524]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; signaling receptor binding [GO:0005102]; small protein activating enzyme binding [GO:0044388]; superoxide dismutase copper chaperone activity [GO:0016532]; transcription coactivator activity [GO:0003713]; tyrosine 3-monooxygenase activator activity [GO:0036470]; ubiquitin-like protein conjugating enzyme binding [GO:0044390]; ubiquitin-specific protease binding [GO:1990381] | 81429.73813841515 | -0.738454879067619 | 8.57619618689237E-7 | 1.34234054129647E-5 |
| P24593 | P24593 | IBP5_HUMAN | Insulin-like growth factor-binding protein 5 (IBP-5) (IGF-binding protein 5) (IGFBP-5) | IGFBP5 | cellular response to cAMP [GO:0071320]; cellular response to organic cyclic compound [GO:0071407]; female pregnancy [GO:0007565]; glucose homeostasis [GO:0042593]; hair follicle morphogenesis [GO:0031069]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular signal transduction [GO:0035556]; lung alveolus development [GO:0048286]; mammary gland involution [GO:0060056]; negative regulation of cell migration [GO:0030336]; negative regulation of growth [GO:0045926]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; negative regulation of muscle tissue development [GO:1901862]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of skeletal muscle hypertrophy [GO:1904205]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of translation [GO:0017148]; osteoblast differentiation [GO:0001649]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; regulation of cell growth [GO:0001558]; regulation of insulin-like growth factor receptor signaling pathway [GO:0043567]; response to growth hormone [GO:0060416]; signal transduction [GO:0007165]; striated muscle cell differentiation [GO:0051146]; type B pancreatic cell proliferation [GO:0044342] | endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; insulin-like growth factor binding protein complex [GO:0016942]; insulin-like growth factor ternary complex [GO:0042567] | fibronectin binding [GO:0001968]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995] | 269091.4632941495 | 1.43449018714738 | 8.6792623337403E-7 | 1.35473003809842E-5 |
| P61289 | P61289 | PSME3_HUMAN | Proteasome activator complex subunit 3 (11S regulator complex subunit gamma) (REG-gamma) (Activator of multicatalytic protease subunit 3) (Ki nuclear autoantigen) (Proteasome activator 28 subunit gamma) (PA28g) (PA28gamma) | PSME3 | apoptotic process [GO:0006915]; cell cycle [GO:0007049]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of proteasomal protein catabolic process [GO:0061136] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome activator complex [GO:0008537]; proteasome complex [GO:0000502] | endopeptidase activator activity [GO:0061133]; identical protein binding [GO:0042802]; MDM2/MDM4 family protein binding [GO:0097371]; p53 binding [GO:0002039] | 28683.401018863253 | 0.363771749564938 | 9.37275540566705E-7 | 1.4589569266074E-5 |
| Q13907 | Q13907 | IDI1_HUMAN | Isopentenyl-diphosphate Delta-isomerase 1 (EC 5.3.3.2) (Isopentenyl pyrophosphate isomerase 1) (IPP isomerase 1) (IPPI1) | IDI1 | cholesterol biosynthetic process [GO:0006695]; dimethylallyl diphosphate biosynthetic process [GO:0050992]; isopentenyl diphosphate biosynthetic process [GO:0009240]; isoprenoid biosynthetic process [GO:0008299] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; peroxisome [GO:0005777] | isopentenyl-diphosphate delta-isomerase activity [GO:0004452]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; metal ion binding [GO:0046872] | 42703.234888157895 | 0.483779415079303 | 1.00162303884939E-6 | 1.55484825701936E-5 |
| P49888 | P49888 | ST1E1_HUMAN | Sulfotransferase 1E1 (ST1E1) (EC 2.8.2.4) (EST-1) (Estrogen sulfotransferase) (Sulfotransferase, estrogen-preferring) | SULT1E1 | 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; estrogen catabolic process [GO:0006711]; estrogen metabolic process [GO:0008210]; ethanol catabolic process [GO:0006068]; positive regulation of fat cell differentiation [GO:0045600]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965] | aryl sulfotransferase activity [GO:0004062]; estrone sulfotransferase activity [GO:0004304]; flavonol 3-sulfotransferase activity [GO:0047894]; steroid binding [GO:0005496]; steroid sulfotransferase activity [GO:0050294]; sulfotransferase activity [GO:0008146] | 59235.15303296005 | -0.350221785410665 | 1.14327912164461E-6 | 1.76989603913616E-5 |
| P20936 | P20936 | RASA1_HUMAN | Ras GTPase-activating protein 1 (GAP) (GTPase-activating protein) (RasGAP) (Ras p21 protein activator) (p120GAP) | RASA1 | blood vessel morphogenesis [GO:0048514]; ephrin receptor signaling pathway [GO:0048013]; intracellular signal transduction [GO:0035556]; mitotic cytokinesis [GO:0000281]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of neuron apoptotic process [GO:0043524]; regulation of actin filament polymerization [GO:0030833]; regulation of cell shape [GO:0008360]; regulation of RNA metabolic process [GO:0051252]; signal transduction [GO:0007165]; vasculogenesis [GO:0001570] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ruffle [GO:0001726] | GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; phosphotyrosine residue binding [GO:0001784]; potassium channel inhibitor activity [GO:0019870]; signaling receptor binding [GO:0005102] | 13050.477919640201 | -0.484361645442586 | 1.2006498944453E-6 | 1.85364640379485E-5 |
| P52907 | P52907 | CAZA1_HUMAN | F-actin-capping protein subunit alpha-1 (CapZ alpha-1) | CAPZA1 | actin cytoskeleton organization [GO:0030036]; barbed-end actin filament capping [GO:0051016]; cell junction assembly [GO:0034329]; protein-containing complex assembly [GO:0065003] | actin cytoskeleton [GO:0015629]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; F-actin capping protein complex [GO:0008290]; WASH complex [GO:0071203] | actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296] | 477797.48050841154 | 0.424582360337331 | 1.21703781970814E-6 | 1.87384138219193E-5 |
| Q8NFW8 | Q8NFW8 | NEUA_HUMAN | N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) (CMP-N-acetylneuraminic acid synthase) (CMP-NeuNAc synthase) | CMAS | N-acetylneuraminate metabolic process [GO:0006054] | membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | N-acylneuraminate cytidylyltransferase activity [GO:0008781] | 25463.742018841098 | 0.20312780347069 | 1.26646204612969E-6 | 1.94465418790537E-5 |
| P40261 | P40261 | NNMT_HUMAN | Nicotinamide N-methyltransferase (EC 2.1.1.1) | NNMT | animal organ regeneration [GO:0031100]; methylation [GO:0032259]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; nicotinamide metabolic process [GO:0006769]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of protein deacetylation [GO:0090312]; response to organonitrogen compound [GO:0010243]; response to xenobiotic stimulus [GO:0009410] | cytosol [GO:0005829] | nicotinamide N-methyltransferase activity [GO:0008112]; pyridine N-methyltransferase activity [GO:0030760] | 178422.83848311548 | -0.42349494543289 | 1.28439383210361E-6 | 1.9668582304592E-5 |
| Q08AM6 | Q08AM6 | VAC14_HUMAN | Protein VAC14 homolog (Tax1-binding protein 2) | VAC14 | phosphatidylinositol biosynthetic process [GO:0006661]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; signal transduction [GO:0007165] | cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; PAS complex [GO:0070772]; presynaptic endosome [GO:0098830] | identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023] | 7711.2583181438495 | -0.370505085150158 | 1.37608250937064E-6 | 2.10158584854287E-5 |
| P15586 | P15586 | GNS_HUMAN | N-acetylglucosamine-6-sulfatase (EC 3.1.6.14) (Glucosamine-6-sulfatase) (G6S) | GNS | glycosaminoglycan catabolic process [GO:0006027]; keratan sulfate catabolic process [GO:0042340] | azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202] | glycosaminoglycan binding [GO:0005539]; metal ion binding [GO:0046872]; N-acetylglucosamine-6-sulfatase activity [GO:0008449]; sulfate binding [GO:0043199]; sulfuric ester hydrolase activity [GO:0008484] | 66188.29984003295 | 0.562017124334661 | 1.40098356917549E-6 | 2.13386368358825E-5 |
| Q9H1E5 | Q9H1E5 | TMX4_HUMAN | Thioredoxin-related transmembrane protein 4 (Thioredoxin domain-containing protein 13) | TMX4 | endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nuclear inner membrane [GO:0005637] | disulfide oxidoreductase activity [GO:0015036] | 23701.72133691675 | 0.550223999684411 | 1.45818049089614E-6 | 2.2150269869752E-5 | |
| P31948 | P31948 | STIP1_HUMAN | Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521) | STIP1 | cellular response to interleukin-7 [GO:0098761] | cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; protein-containing complex [GO:0032991] | Hsp90 protein binding [GO:0051879]; RNA binding [GO:0003723] | 69417.7741576495 | 0.17506590222809 | 1.48229244520572E-6 | 2.24563342099882E-5 |
| O00214 | O00214 | LEG8_HUMAN | Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1) | LGALS8 | cellular response to virus [GO:0098586]; lymphatic endothelial cell migration [GO:1904977]; xenophagy [GO:0098792] | cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020] | carbohydrate binding [GO:0030246]; integrin binding [GO:0005178] | 46553.54973450785 | 0.381641830201371 | 1.48632257069325E-6 | 2.24573431614613E-5 |
| P60891 | P60891 | PRPS1_HUMAN | Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase I) (PRS-I) | PRPS1 | 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; hypoxanthine biosynthetic process [GO:0046101]; nervous system development [GO:0007399]; phosphorylation [GO:0016310]; purine nucleobase metabolic process [GO:0006144]; purine nucleotide biosynthetic process [GO:0006164]; pyrimidine nucleotide biosynthetic process [GO:0006221]; ribonucleoside monophosphate biosynthetic process [GO:0009156]; urate biosynthetic process [GO:0034418] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; ribose phosphate diphosphokinase complex [GO:0002189] | ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; ribose phosphate diphosphokinase activity [GO:0004749] | 24881.265242033347 | -0.342145356220171 | 1.522701256675E-6 | 2.29458120221291E-5 |
| P51580 | P51580 | TPMT_HUMAN | Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) | TPMT | methylation [GO:0032259]; nucleobase-containing compound metabolic process [GO:0006139]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805] | cytosol [GO:0005829] | S-adenosyl-L-methionine binding [GO:1904047]; thiopurine S-methyltransferase activity [GO:0008119] | 31285.8828231227 | 0.429868345128012 | 1.56739717329894E-6 | 2.35566906735061E-5 |
| O75828 | O75828 | CBR3_HUMAN | Carbonyl reductase [NADPH] 3 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 3) (Quinone reductase CBR3) (EC 1.6.5.10) (Short chain dehydrogenase/reductase family 21C member 2) | CBR3 | cognition [GO:0050890]; phylloquinone catabolic process [GO:0042376]; xenobiotic metabolic process [GO:0006805] | cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654] | 3-keto sterol reductase activity [GO:0000253]; carbonyl reductase (NADPH) activity [GO:0004090]; NADPH binding [GO:0070402]; NADPH dehydrogenase (quinone) activity [GO:0008753] | 54182.650176913 | 0.40570343456252 | 1.58531374696109E-6 | 2.37629303975702E-5 |
| Q8NDI1 | Q8NDI1 | EHBP1_HUMAN | EH domain-binding protein 1 | EHBP1 | actin cytoskeleton organization [GO:0030036]; endocytosis [GO:0006897]; protein transport [GO:0015031] | cytosol [GO:0005829]; endosome [GO:0005768]; filamentous actin [GO:0031941]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] | 5866.367682115805 | -0.43700412854129 | 1.71944682196496E-6 | 2.5705503148426E-5 | |
| Q9BRR6 | Q9BRR6 | ADPGK_HUMAN | ADP-dependent glucokinase (ADP-GK) (ADPGK) (EC 2.7.1.147) (RbBP-35) | ADPGK | glucose metabolic process [GO:0006006]; glycolytic process through glucose-6-phosphate [GO:0061620]; phosphorylation [GO:0016310] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; membrane [GO:0016020] | ADP-specific glucokinase activity [GO:0043843]; metal ion binding [GO:0046872] | 31045.81846259145 | 0.349257177783927 | 1.72939085703251E-6 | 2.5718447758389E-5 |
| P83111 | P83111 | LACTB_HUMAN | Serine beta-lactamase-like protein LACTB, mitochondrial (EC 3.4.-.-) | LACTB | lipid metabolic process [GO:0006629]; proteolysis [GO:0006508]; regulation of lipid metabolic process [GO:0019216] | cytosol [GO:0005829]; mitochondrion [GO:0005739] | identical protein binding [GO:0042802]; peptidase activity [GO:0008233] | 23151.6946127196 | 0.24795249152199 | 1.72768897436235E-6 | 2.5718447758389E-5 |
| O00754 | O00754 | MA2B1_HUMAN | Lysosomal alpha-mannosidase (Laman) (EC 3.2.1.24) (Lysosomal acid alpha-mannosidase) (Mannosidase alpha class 2B member 1) (Mannosidase alpha-B) [Cleaved into: Lysosomal alpha-mannosidase A peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha-mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha-mannosidase E peptide] | MAN2B1 | learning or memory [GO:0007611]; mannose metabolic process [GO:0006013]; N-glycan processing [GO:0006491]; oligosaccharide catabolic process [GO:0009313]; protein deglycosylation [GO:0006517]; protein modification process [GO:0036211] | azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; nucleoplasm [GO:0005654] | alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] | 35565.672608326495 | 0.416351926598179 | 1.75442989709757E-6 | 2.60225125574733E-5 |
| Q7L1Q6 | Q7L1Q6 | 5MP2_HUMAN | eIF5-mimic protein 2 (Basic leucine zipper and W2 domain-containing protein 1) (Protein Orf) | BZW1 | regulation of translational initiation [GO:0006446] | cytoplasm [GO:0005737]; membrane [GO:0016020] | cadherin binding [GO:0045296]; RNA binding [GO:0003723] | 55746.370619213805 | 0.389586000329115 | 1.79653771564963E-6 | 2.6577500514023E-5 |
| O95716 | O95716 | RAB3D_HUMAN | Ras-related protein Rab-3D | RAB3D | bone resorption [GO:0045453]; positive regulation of regulated secretory pathway [GO:1903307]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; regulation of exocytosis [GO:0017157]; vesicle docking involved in exocytosis [GO:0006904] | azurophil granule membrane [GO:0035577]; cytoplasmic microtubule [GO:0005881]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; secretory vesicle [GO:0099503]; synaptic vesicle [GO:0008021]; zymogen granule [GO:0042588] | GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489] | 8028.34188611788 | 0.953164372687395 | 1.82472452456488E-6 | 2.69241905108974E-5 |
| Q8NEU8 | Q8NEU8 | DP13B_HUMAN | DCC-interacting protein 13-beta (Dip13-beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2) | APPL2 | adiponectin-activated signaling pathway [GO:0033211]; cell cycle [GO:0007049]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cold acclimation [GO:0009631]; diet induced thermogenesis [GO:0002024]; glucose homeostasis [GO:0042593]; negative regulation of cellular response to insulin stimulus [GO:1900077]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of fatty acid oxidation [GO:0046322]; negative regulation of glucose import [GO:0046325]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neurogenesis [GO:0050768]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis [GO:1905451]; positive regulation of macropinocytosis [GO:1905303]; positive regulation of phagocytosis, engulfment [GO:0060100]; protein homotetramerization [GO:0051289]; protein import into nucleus [GO:0006606]; regulation of fibroblast migration [GO:0010762]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of innate immune response [GO:0045088]; regulation of toll-like receptor 4 signaling pathway [GO:0034143]; signal transduction [GO:0007165]; signaling [GO:0023052]; transforming growth factor beta receptor signaling pathway [GO:0007179] | cytoplasmic vesicle [GO:0031410]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; early phagosome membrane [GO:0036186]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; macropinosome [GO:0044354]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; vesicle [GO:0031982] | identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; phosphatidylserine binding [GO:0001786]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877] | 14610.1426719479 | -0.486693151295901 | 1.84225107471163E-6 | 2.71121937384833E-5 |
| Q9BQL6 | Q9BQL6 | FERM1_HUMAN | Fermitin family homolog 1 (Kindlerin) (Kindlin syndrome protein) (Kindlin-1) (Unc-112-related protein 1) | FERMT1 | basement membrane organization [GO:0071711]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; establishment of epithelial cell polarity [GO:0090162]; integrin-mediated signaling pathway [GO:0007229]; keratinocyte migration [GO:0051546]; keratinocyte proliferation [GO:0043616]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of gene expression [GO:0010629]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of timing of anagen [GO:0051886]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of integrin activation [GO:0033625]; positive regulation of transforming growth factor beta production [GO:0071636]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of wound healing, spreading of epidermal cells [GO:1903691] | cell junction [GO:0030054]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; ruffle membrane [GO:0032587] | actin filament binding [GO:0051015]; integrin binding [GO:0005178] | 12950.7074462287 | 0.645031052145709 | 1.85515950580908E-6 | 2.72314346111769E-5 |
| Q13423 | Q13423 | NNTM_HUMAN | NAD(P) transhydrogenase, mitochondrial (EC 7.1.1.1) (Nicotinamide nucleotide transhydrogenase) (Pyridine nucleotide transhydrogenase) | NNT | cell redox homeostasis [GO:0045454]; cellular oxidant detoxification [GO:0098869]; intracellular oxygen homeostasis [GO:0032364]; NADPH regeneration [GO:0006740]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of hydrogen peroxide catabolic process [GO:1903285]; positive regulation of mitochondrial membrane potential [GO:0010918]; proton transmembrane transport [GO:1902600]; reactive oxygen species metabolic process [GO:0072593]; response to vitamin [GO:0033273]; tricarboxylic acid cycle [GO:0006099] | membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial respirasome [GO:0005746]; mitochondrion [GO:0005739] | NAD binding [GO:0051287]; NAD(P)+ transhydrogenase (B-specific) activity [GO:0003957]; NAD(P)+ transhydrogenase activity [GO:0008746]; NADP binding [GO:0050661] | 14088.1333787254 | -0.363888555255827 | 1.89734145261861E-6 | 2.7778647727486E-5 |
| Q9HAV7 | Q9HAV7 | GRPE1_HUMAN | GrpE protein homolog 1, mitochondrial (HMGE) (Mt-GrpE#1) | GRPEL1 | intracellular protein transport [GO:0006886]; protein folding [GO:0006457]; protein import into mitochondrial matrix [GO:0030150] | mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; PAM complex, Tim23 associated import motor [GO:0001405]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744] | adenyl-nucleotide exchange factor activity [GO:0000774]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] | 64917.188412336 | 0.688069010421177 | 1.93944747779922E-6 | 2.8321931467037E-5 |
| Q15800 | Q15800 | MSMO1_HUMAN | Methylsterol monooxygenase 1 (EC 1.14.18.9) (C-4 methylsterol oxidase) (Sterol-C4-methyl oxidase) | MSMO1 | cholesterol biosynthetic process [GO:0006695]; cholesterol biosynthetic process via lathosterol [GO:0033490]; ergosterol biosynthetic process [GO:0006696]; fatty acid metabolic process [GO:0006631]; sphingolipid biosynthetic process [GO:0030148]; steroid metabolic process [GO:0008202]; sterol biosynthetic process [GO:0016126] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] | C-4 methylsterol oxidase activity [GO:0000254]; C-5 sterol desaturase activity [GO:0000248]; iron ion binding [GO:0005506]; sphingolipid delta-4 desaturase activity [GO:0042284]; sphingosine hydroxylase activity [GO:0000170] | 11916.61420481715 | 0.917554575258554 | 2.00782430734825E-6 | 2.92450707594734E-5 |
| P08238 | P08238 | HS90B_HUMAN | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | HSP90AB1 | cellular response to heat [GO:0034605]; cellular response to interleukin-4 [GO:0071353]; chaperone-mediated protein complex assembly [GO:0051131]; negative regulation of apoptotic process [GO:0043066]; negative regulation of proteasomal protein catabolic process [GO:1901799]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of transforming growth factor beta activation [GO:1901389]; placenta development [GO:0001890]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cyclin-dependent protein kinase activity [GO:1904031]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of tau-protein kinase activity [GO:1902949]; positive regulation of telomerase activity [GO:0051973]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]; regulation of protein localization [GO:0032880]; regulation of protein ubiquitination [GO:0031396]; response to unfolded protein [GO:0006986]; supramolecular fiber organization [GO:0097435]; telomerase holoenzyme complex assembly [GO:1905323]; telomere maintenance via telomerase [GO:0007004]; virion attachment to host cell [GO:0019062] | aryl hydrocarbon receptor complex [GO:0034751]; axonal growth cone [GO:0044295]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic growth cone [GO:0044294]; dynein axonemal particle [GO:0120293]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; HSP90-CDC37 chaperone complex [GO:1990565]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein binding [GO:0043008]; ATP-dependent protein folding chaperone [GO:0140662]; cadherin binding [GO:0045296]; disordered domain specific binding [GO:0097718]; DNA polymerase binding [GO:0070182]; double-stranded RNA binding [GO:0003725]; heat shock protein binding [GO:0031072]; histone deacetylase binding [GO:0042826]; histone methyltransferase binding [GO:1990226]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; MHC class II protein complex binding [GO:0023026]; nitric-oxide synthase regulator activity [GO:0030235]; peptide binding [GO:0042277]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; RNA binding [GO:0003723]; tau protein binding [GO:0048156]; TPR domain binding [GO:0030911]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082] | 303787.6910119365 | 0.183833450104504 | 2.04495639459058E-6 | 2.97095459788467E-5 |
| Q68CR1 | Q68CR1 | SE1L3_HUMAN | Protein sel-1 homolog 3 (Suppressor of lin-12-like protein 3) (Sel-1L3) | SEL1L3 | membrane [GO:0016020] | 7808.3202176707655 | -0.500576271125701 | 2.07978855401859E-6 | 3.01383170001773E-5 | ||
| O75521 | O75521 | ECI2_HUMAN | Enoyl-CoA delta isomerase 2 (EC 5.3.3.8) (DRS-1) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Diazepam-binding inhibitor-related protein 1) (DBI-related protein 1) (Dodecenoyl-CoA isomerase) (Hepatocellular carcinoma-associated antigen 88) (Peroxisomal 3,2-trans-enoyl-CoA isomerase) (pECI) (Renal carcinoma antigen NY-REN-1) | ECI2 | fatty acid beta-oxidation [GO:0006635]; fatty acid catabolic process [GO:0009062] | cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777] | delta(3)-delta(2)-enoyl-CoA isomerase activity [GO:0004165]; fatty-acyl-CoA binding [GO:0000062] | 16795.15355668125 | 0.364945572730272 | 2.13988203620312E-6 | 3.09300296355277E-5 |
| Q9H9B4 | Q9H9B4 | SFXN1_HUMAN | Sideroflexin-1 | SFXN1 | erythrocyte differentiation [GO:0030218]; iron ion transport [GO:0006826]; L-alanine transport [GO:0015808]; L-serine transport [GO:0015825]; one-carbon metabolic process [GO:0006730]; serine import into mitochondrion [GO:0140300] | mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] | L-alanine transmembrane transporter activity [GO:0015180]; L-serine transmembrane transporter activity [GO:0015194]; monoatomic ion transmembrane transporter activity [GO:0015075] | 16913.6843608866 | -1.10576127305661 | 2.21018641416848E-6 | 3.18649267752636E-5 |
| O43570 | O43570 | CAH12_HUMAN | Carbonic anhydrase 12 (EC 4.2.1.1) (Carbonate dehydratase XII) (Carbonic anhydrase XII) (CA-XII) (Tumor antigen HOM-RCC-3.1.3) | CA12 | chloride ion homeostasis [GO:0055064]; estrous cycle [GO:0044849]; one-carbon metabolic process [GO:0006730] | apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886] | carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270] | 14828.250087335451 | 0.816211075453724 | 2.22398351460764E-6 | 3.19824634359566E-5 |
| O14828 | O14828 | SCAM3_HUMAN | Secretory carrier-associated membrane protein 3 (Secretory carrier membrane protein 3) | SCAMP3 | post-Golgi vesicle-mediated transport [GO:0006892]; protein transport [GO:0015031] | extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; recycling endosome membrane [GO:0055038]; trans-Golgi network membrane [GO:0032588] | ubiquitin protein ligase binding [GO:0031625] | 35754.68542664555 | -1.06518783839799 | 2.28741862609191E-6 | 3.281142768465E-5 |
| P27797 | P27797 | CALR_HUMAN | Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) | CALR | cardiac muscle cell differentiation [GO:0055007]; cellular response to electrical stimulus [GO:0071257]; cellular response to lithium ion [GO:0071285]; cellular response to virus [GO:0098586]; cellular senescence [GO:0090398]; cortical actin cytoskeleton organization [GO:0030866]; ERAD pathway [GO:0036503]; glucocorticoid receptor signaling pathway [GO:0042921]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intracellular steroid hormone receptor signaling pathway [GO:0033144]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; negative regulation of trophoblast cell migration [GO:1901164]; peptide antigen assembly with MHC class I protein complex [GO:0002502]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of gene expression [GO:0010628]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of phagocytosis [GO:0050766]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein export from nucleus [GO:0006611]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; protein localization to nucleus [GO:0034504]; protein maturation by protein folding [GO:0022417]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of DNA-templated transcription [GO:0006355]; regulation of meiotic nuclear division [GO:0040020]; response to estradiol [GO:0032355]; response to glycoside [GO:1903416]; response to testosterone [GO:0033574]; response to xenobiotic stimulus [GO:0009410]; sequestering of calcium ion [GO:0051208]; spermatogenesis [GO:0007283] | acrosomal vesicle [GO:0001669]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cortical granule [GO:0060473]; cytolytic granule [GO:0044194]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; MHC class I peptide loading complex [GO:0042824]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; ribosome [GO:0005840]; sarcoplasmic reticulum lumen [GO:0033018]; smooth endoplasmic reticulum [GO:0005790] | calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; complement component C1q complex binding [GO:0001849]; DNA binding [GO:0003677]; hormone binding [GO:0042562]; integrin binding [GO:0005178]; iron ion binding [GO:0005506]; molecular sequestering activity [GO:0140313]; mRNA binding [GO:0003729]; nuclear androgen receptor binding [GO:0050681]; nuclear export signal receptor activity [GO:0005049]; peptide binding [GO:0042277]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270] | 548688.554500988 | 0.371519143990198 | 2.29526709521126E-6 | 3.28408670744117E-5 |
| P42126 | P42126 | ECI1_HUMAN | Enoyl-CoA delta isomerase 1, mitochondrial (EC 5.3.3.8) (3,2-trans-enoyl-CoA isomerase) (Delta(3),Delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Dodecenoyl-CoA isomerase) | ECI1 | fatty acid beta-oxidation [GO:0006635] | mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] | delta(3)-delta(2)-enoyl-CoA isomerase activity [GO:0004165]; intramolecular oxidoreductase activity, transposing C=C bonds [GO:0016863] | 20814.232172641903 | -0.434736242545442 | 2.34804666095664E-6 | 3.35114165767767E-5 |
| P52789 | P52789 | HXK2_HUMAN | Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase) | HK2 | apoptotic mitochondrial changes [GO:0008637]; canonical glycolysis [GO:0061621]; carbohydrate phosphorylation [GO:0046835]; cellular response to leukemia inhibitory factor [GO:1990830]; establishment of protein localization to mitochondrion [GO:0072655]; fructose 6-phosphate metabolic process [GO:0006002]; glucose 6-phosphate metabolic process [GO:0051156]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; intracellular glucose homeostasis [GO:0001678]; lactation [GO:0007595]; maintenance of protein location in mitochondrion [GO:0072656]; negative regulation of mitochondrial membrane permeability [GO:0035795]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization [GO:1904925]; regulation of glucose import [GO:0046324]; response to hypoxia [GO:0001666]; response to ischemia [GO:0002931] | centrosome [GO:0005813]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; sarcoplasmic reticulum [GO:0016529] | ATP binding [GO:0005524]; fructokinase activity [GO:0008865]; glucokinase activity [GO:0004340]; glucose binding [GO:0005536]; hexokinase activity [GO:0004396] | 29650.91933264835 | 0.26821898206375 | 2.35550030852261E-6 | 3.35333285127866E-5 |
| O95817 | O95817 | BAG3_HUMAN | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | BAG3 | aggresome assembly [GO:0070842]; autophagosome assembly [GO:0000045]; cellular response to heat [GO:0034605]; cellular response to mechanical stimulus [GO:0071260]; cellular response to unfolded protein [GO:0034620]; chaperone-mediated autophagy [GO:0061684]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of apoptotic process [GO:0043066]; negative regulation of striated muscle cell apoptotic process [GO:0010664]; positive regulation of aggrephagy [GO:1905337]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein import into nucleus [GO:0042307]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; protein transport along microtubule [GO:0098840]; striated muscle cell apoptotic process [GO:0010658] | aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; stress fiber [GO:0001725]; Z disc [GO:0030018] | adenyl-nucleotide exchange factor activity [GO:0000774]; cadherin binding [GO:0045296]; dynein intermediate chain binding [GO:0045505]; protein carrier chaperone [GO:0140597]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087] | 47683.428034405355 | 0.319785043209777 | 2.39296450048236E-6 | 3.39812953878021E-5 |
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| Q15149 | |||||||||
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