Selected Cell
Cell:
Value:
stat_data__min_2_Peptides
Sheet1
A
B
C
D
E
F
G
H
I
J
K
L
3001
3002
3003
3004
3005
3006
3007
3008
3009
3010
3011
3012
3013
3014
3015
3016
3017
3018
3019
3020
3021
3022
3023
3024
3025
3026
3027
3028
3029
3030
3031
3032
3033
3034
3035
3036
3037
3038
3039
3040
3041
3042
3043
3044
3045
3046
3047
3048
3049
3050
3051
3052
3053
3054
3055
3056
3057
3058
3059
3060
3061
3062
3063
3064
3065
3066
3067
3068
3069
3070
3071
3072
3073
3074
3075
3076
3077
3078
3079
3080
3081
3082
3083
3084
3085
3086
3087
3088
3089
3090
3091
3092
3093
3094
3095
3096
3097
3098
3099
3100
3101
3102
3103
3104
3105
3106
3107
3108
3109
3110
3111
3112
3113
3114
3115
3116
3117
3118
3119
3120
3121
3122
3123
3124
3125
3126
3127
3128
3129
3130
3131
3132
3133
3134
3135
3136
3137
3138
3139
3140
3141
3142
3143
3144
3145
3146
3147
3148
3149
3150
3151
3152
3153
3154
3155
3156
3157
3158
3159
3160
3161
3162
3163
3164
3165
3166
3167
3168
3169
3170
3171
3172
3173
3174
3175
3176
3177
3178
3179
3180
3181
3182
3183
3184
3185
3186
3187
3188
3189
3190
3191
3192
3193
3194
3195
3196
3197
3198
3199
3200
| Q96EQ0 | Q96EQ0 | SGTB_HUMAN | Small glutamine-rich tetratricopeptide repeat-containing protein beta (Beta-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 2) | SGTB | post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260] | membrane [GO:0016020]; TRC complex [GO:0072380] | Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090] | 68648.24633983275 | 0.119856911181729 | 0.559326484454578 | 0.915144054553751 |
| Q9BY77 | Q9BY77 | PDIP3_HUMAN | Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR) | POLDIP3 | poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of translation [GO:0045727] | cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | mRNA binding [GO:0003729]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723] | 15810.920209213451 | 0.135203033540791 | 0.560879342150276 | 0.916890465269321 |
| Q6PJT7 | Q6PJT7 | ZC3HE_HUMAN | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | ZC3H14 | negative regulation of mRNA polyadenylation [GO:1900364]; regulation of mRNA stability [GO:0043488] | axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; dendrite cytoplasm [GO:0032839]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] | metal ion binding [GO:0046872]; poly(A) binding [GO:0008143]; RNA binding [GO:0003723] | 7111.63400602945 | -0.169559785060083 | 0.561622831822415 | 0.917576402856344 |
| Q16629 | Q16629 | SRSF7_HUMAN | Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7) | SRSF7 | cellular response to leukemia inhibitory factor [GO:1990830]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transport [GO:0051028]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; RNA splicing [GO:0008380] | cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] | 93079.51737957564 | 0.117672724274065 | 0.562135067846612 | 0.918148542640215 |
| Q15833 | Q15833 | STXB2_HUMAN | Syntaxin-binding protein 2 (Protein unc-18 homolog 2) (Unc18-2) (Protein unc-18 homolog B) (Unc-18B) | STXBP2 | intracellular protein transport [GO:0006886]; leukocyte mediated cytotoxicity [GO:0001909]; neurotransmitter secretion [GO:0007269]; neutrophil degranulation [GO:0043312]; regulation of mast cell degranulation [GO:0043304]; vesicle docking involved in exocytosis [GO:0006904]; vesicle-mediated transport [GO:0016192] | azurophil granule [GO:0042582]; cytolytic granule [GO:0044194]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; secretory granule [GO:0030141]; specific granule [GO:0042581]; tertiary granule [GO:0070820] | syntaxin-1 binding [GO:0017075]; syntaxin-3 binding [GO:0030348] | 11105.7663157526 | -0.275867610405143 | 0.563558481985012 | 0.920208172601463 |
| Q96PU5 | Q96PU5 | NED4L_HUMAN | E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) | NEDD4L | cell differentiation [GO:0030154]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of sodium ion transmembrane transport [GO:1902306]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; positive regulation of caveolin-mediated endocytosis [GO:2001288]; positive regulation of dendrite extension [GO:1903861]; positive regulation of protein catabolic process [GO:0045732]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; regulation of dendrite morphogenesis [GO:0048814]; regulation of membrane depolarization [GO:0003254]; regulation of membrane potential [GO:0042391]; regulation of membrane repolarization [GO:0060306]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of potassium ion transmembrane transporter activity [GO:1901016]; regulation of protein stability [GO:0031647]; regulation of sodium ion transmembrane transport [GO:1902305]; ubiquitin-dependent protein catabolic process [GO:0006511]; ventricular cardiac muscle cell action potential [GO:0086005] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; multivesicular body [GO:0005771]; nucleoplasm [GO:0005654] | potassium channel inhibitor activity [GO:0019870]; potassium channel regulator activity [GO:0015459]; sodium channel inhibitor activity [GO:0019871]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] | 4285.8959773171355 | 0.184555063655177 | 0.564251254184003 | 0.92054350884151 |
| Q9C0J8 | Q9C0J8 | WDR33_HUMAN | pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa) | WDR33 | mRNA polyadenylation [GO:0006378]; postreplication repair [GO:0006301]; spermatogenesis [GO:0007283] | collagen trimer [GO:0005581]; fibrillar center [GO:0001650]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | RNA binding [GO:0003723] | 5186.52942770607 | 0.23244667680963 | 0.56442377613557 | 0.920559906616045 |
| P52294 | P52294 | IMA5_HUMAN | Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed] | KPNA1 | NLS-bearing protein import into nucleus [GO:0006607]; postsynapse to nucleus signaling pathway [GO:0099527]; protein import into nucleus [GO:0006606]; regulation of apoptotic process [GO:0042981]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of DNA recombination [GO:0000018]; satellite cell activation involved in skeletal muscle regeneration [GO:0014901]; skeletal muscle satellite cell proliferation [GO:0014841] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] | nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139] | 37357.33022354675 | -0.101671087246433 | 0.564699691116365 | 0.920744877659086 |
| P12074 | P12074 | CX6A1_HUMAN | Cytochrome c oxidase subunit 6A1, mitochondrial (Cytochrome c oxidase polypeptide VIa-liver) (Cytochrome c oxidase subunit VIA-liver) (COX VIa-L) | COX6A1 | cellular respiration [GO:0045333]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123] | mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739] | enzyme regulator activity [GO:0030234]; oxidoreductase activity [GO:0016491] | 8239.44053509087 | 0.34522150762963 | 0.56544196160625 | 0.921159906400521 |
| P04259 | P04259 | K2C6B_HUMAN | Keratin, type II cytoskeletal 6B (Cytokeratin-6B) (CK-6B) (Keratin-6B) (K6B) (Type-II keratin Kb10) | KRT6B | ectoderm development [GO:0007398]; intermediate filament organization [GO:0045109]; keratinization [GO:0031424] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095] | structural constituent of cytoskeleton [GO:0005200]; structural constituent of skin epidermis [GO:0030280] | 13498.790536433 | 0.809842391280724 | 0.565352845402809 | 0.921159906400521 |
| Q3ZCM7 | Q3ZCM7 | TBB8_HUMAN | Tubulin beta-8 chain (Tubulin beta 8 class VIII) | TUBB8 | microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]; oocyte maturation [GO:0001556]; spindle assembly involved in female meiosis [GO:0007056] | cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; meiotic spindle [GO:0072687]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686] | GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200] | 42367.47077063485 | 0.604243466364149 | 0.565389688196558 | 0.921159906400521 |
| Q8IZ52 | Q8IZ52 | CHSS2_HUMAN | Chondroitin sulfate synthase 2 (EC 2.4.1.175) (EC 2.4.1.226) (Chondroitin glucuronyltransferase 2) (Chondroitin-polymerizing factor) (ChPF) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II) (N-acetylgalactosaminyltransferase 2) | CHPF | chondroitin sulfate biosynthetic process [GO:0030206] | cytosol [GO:0005829]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; mitochondrial matrix [GO:0005759] | glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; metal ion binding [GO:0046872]; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity [GO:0050510] | 6779.360191263255 | -0.192717580222879 | 0.566052848118138 | 0.921379569283006 |
| P32456 | P32456 | GBP2_HUMAN | Guanylate-binding protein 2 (EC 3.6.5.-) (GTP-binding protein 2) (GBP-2) (HuGBP-2) (Guanine nucleotide-binding protein 2) (Interferon-induced guanylate-binding protein 2) | GBP2 | activation of innate immune response [GO:0002218]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; cytolysis in another organism [GO:0051715]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; immune response [GO:0006955]; positive regulation of AIM2 inflammasome complex assembly [GO:0140973]; positive regulation of pyroptosis [GO:0140639]; protein localization to nucleus [GO:0034504] | cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] | endopeptidase inhibitor activity [GO:0004866]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular function inhibitor activity [GO:0140678]; protein homodimerization activity [GO:0042803] | 9638.805545800209 | -0.29226711647616 | 0.566064645371363 | 0.921379569283006 |
| Q9NTI5 | Q9NTI5 | PDS5B_HUMAN | Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3) | PDS5B | cell division [GO:0051301]; cell population proliferation [GO:0008283]; DNA repair [GO:0006281]; mitotic sister chromatid cohesion [GO:0007064]; negative regulation of cell population proliferation [GO:0008285]; regulation of cell population proliferation [GO:0042127] | chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | DNA binding [GO:0003677] | 1586.336145629335 | 0.406945751106934 | 0.566279031887994 | 0.921463812371446 |
| Q96RP9 | Q96RP9 | EFGM_HUMAN | Elongation factor G, mitochondrial (EF-Gmt) (Elongation factor G 1, mitochondrial) (mEF-G 1) (Elongation factor G1) (hEFG1) | GFM1 | mitochondrial translational elongation [GO:0070125] | mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] | GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746] | 7286.493174928481 | 0.219614092454722 | 0.56712325429351 | 0.922572597997999 |
| O95372 | O95372 | LYPA2_HUMAN | Acyl-protein thioesterase 2 (APT-2) (EC 3.1.2.-) (Lysophospholipase II) (LPL-II) (LysoPLA II) (Palmitoyl-protein hydrolase) (EC 3.1.2.22) | LYPLA2 | acylglycerol catabolic process [GO:0046464]; axon guidance [GO:0007411]; fatty acid metabolic process [GO:0006631]; prostaglandin catabolic process [GO:1905344]; protein depalmitoylation [GO:0002084] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi stack [GO:0005795]; nucleoplasm [GO:0005654] | cadherin binding [GO:0045296]; carboxylic ester hydrolase activity [GO:0052689]; lysophospholipase activity [GO:0004622]; palmitoyl-(protein) hydrolase activity [GO:0008474] | 10259.215825599025 | -0.371532233548836 | 0.568137789891222 | 0.923162809728611 |
| Q53LP3 | Q53LP3 | SWAHC_HUMAN | Ankyrin repeat domain-containing protein SOWAHC (Ankyrin repeat domain-containing protein 57) (Protein sosondowah homolog C) | SOWAHC | 5137.2668244039305 | 0.187442612600116 | 0.56813233410141 | 0.923162809728611 | |||
| Q9P2E3 | Q9P2E3 | ZNFX1_HUMAN | NFX1-type zinc finger-containing protein 1 | ZNFX1 | activation of innate immune response [GO:0002218]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048] | cytoplasmic stress granule [GO:0010494]; mitochondrial outer membrane [GO:0005741]; nuclear RNA-directed RNA polymerase complex [GO:0031380] | helicase activity [GO:0004386]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] | 5001.79565344816 | -0.227670526961611 | 0.567906649780286 | 0.923162809728611 |
| Q5T160 | Q5T160 | SYRM_HUMAN | Probable arginine--tRNA ligase, mitochondrial (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS) | RARS2 | arginyl-tRNA aminoacylation [GO:0006420]; mitochondrial translation [GO:0032543]; tRNA aminoacylation for protein translation [GO:0006418] | mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739] | arginine-tRNA ligase activity [GO:0004814]; ATP binding [GO:0005524]; RNA binding [GO:0003723] | 5791.802896145535 | 0.167989699900241 | 0.568313065450454 | 0.923182863773588 |
| O95573 | O95573 | ACSL3_HUMAN | Fatty acid CoA ligase Acsl3 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 3) (LACS 3) (Long-chain-fatty-acid--CoA ligase 3) (EC 6.2.1.3) (Medium-chain acyl-CoA ligase Acsl3) (EC 6.2.1.2) | ACSL3 | fatty acid metabolic process [GO:0006631]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; neuron differentiation [GO:0030182]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998]; positive regulation of phosphatidylcholine biosynthetic process [GO:2001247]; positive regulation of secretion [GO:0051047]; very-low-density lipoprotein particle assembly [GO:0034379] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal membrane [GO:0005778]; plasma membrane [GO:0005886] | arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; long-chain fatty acid-CoA ligase activity [GO:0004467]; medium-chain fatty acid-CoA ligase activity [GO:0031956]; palmitoyl-CoA ligase activity [GO:0090433]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901] | 28657.3957093067 | -0.134372440831601 | 0.56989219783445 | 0.925217533790829 |
| Q9HD34 | Q9HD34 | LYRM4_HUMAN | LYR motif-containing protein 4 | LYRM4 | [2Fe-2S] cluster assembly [GO:0044571]; [4Fe-4S] cluster assembly [GO:0044572]; iron-sulfur cluster assembly [GO:0016226] | iron-sulfur cluster assembly complex [GO:1990229]; L-cysteine desulfurase complex [GO:1990221]; mitochondrial iron-sulfur cluster assembly complex [GO:0099128]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleus [GO:0005634] | protein homodimerization activity [GO:0042803] | 22294.58207621695 | -0.0997808635940659 | 0.571647883174268 | 0.927322535360801 |
| O75431 | O75431 | MTX2_HUMAN | Metaxin-2 (Mitochondrial outer membrane import complex protein 2) | MTX2 | inner mitochondrial membrane organization [GO:0007007]; mitochondrial transport [GO:0006839]; mitochondrion organization [GO:0007005]; protein insertion into mitochondrial outer membrane [GO:0045040] | cytoplasm [GO:0005737]; MIB complex [GO:0140275]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; SAM complex [GO:0001401] | 12980.08526996555 | -0.204733205202379 | 0.571843441325563 | 0.927322535360801 | |
| O00712 | O00712 | NFIB_HUMAN | Nuclear factor 1 B-type (NF1-B) (Nuclear factor 1/B) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/B) (NF-I/B) (NFI-B) (TGGCA-binding protein) | NFIB | anterior commissure morphogenesis [GO:0021960]; brain development [GO:0007420]; cell differentiation involved in salivary gland development [GO:0060689]; cell proliferation in forebrain [GO:0021846]; chondrocyte differentiation [GO:0002062]; club cell differentiation [GO:0060486]; commissural neuron axon guidance [GO:0071679]; DNA replication [GO:0006260]; exit from mitosis [GO:0010458]; gene expression [GO:0010467]; glandular epithelial cell differentiation [GO:0002067]; glial cell differentiation [GO:0010001]; glial cell fate specification [GO:0021780]; glial cell proliferation [GO:0014009]; hindbrain development [GO:0030902]; lung ciliated cell differentiation [GO:0061141]; negative regulation of DNA binding [GO:0043392]; negative regulation of epithelial cell proliferation involved in lung morphogenesis [GO:2000795]; negative regulation of mesenchymal cell proliferation involved in lung development [GO:2000791]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron fate specification [GO:0048665]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; principal sensory nucleus of trigeminal nerve development [GO:0021740]; regeneration [GO:0031099]; regulation of transcription by RNA polymerase II [GO:0006357]; response to bacterium [GO:0009617]; response to wounding [GO:0009611]; retina development in camera-type eye [GO:0060041]; salivary gland cavitation [GO:0060662]; stem cell population maintenance [GO:0019827]; stem cell proliferation [GO:0072089]; tissue homeostasis [GO:0001894]; type I pneumocyte differentiation [GO:0060509]; type II pneumocyte differentiation [GO:0060510] | cerebellar mossy fiber [GO:0044300]; chromatin [GO:0000785]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription regulator inhibitor activity [GO:0140416] | 12874.60258598335 | -0.130448672041989 | 0.572435216047021 | 0.928016576286815 |
| P02511 | P02511 | CRYAB_HUMAN | Alpha-crystallin B chain (Alpha(B)-crystallin) (Heat shock protein beta-5) (HspB5) (Heat shock protein family B member 5) (Renal carcinoma antigen NY-REN-27) (Rosenthal fiber component) | CRYAB | apoptotic process involved in morphogenesis [GO:0060561]; cellular response to gamma radiation [GO:0071480]; lens development in camera-type eye [GO:0002088]; microtubule polymerization or depolymerization [GO:0031109]; muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of intracellular transport [GO:0032387]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; protein folding [GO:0006457]; protein refolding [GO:0042026]; protein stabilization [GO:0050821]; regulation of programmed cell death [GO:0043067]; response to estradiol [GO:0032355]; response to heat [GO:0009408]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; stress-activated MAPK cascade [GO:0051403]; tubulin complex assembly [GO:0007021] | actin filament bundle [GO:0032432]; axon [GO:0030424]; cardiac myofibril [GO:0097512]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; lysosome [GO:0005764]; M band [GO:0031430]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; protein-containing complex [GO:0032991]; synaptic membrane [GO:0097060]; Z disc [GO:0030018] | amyloid-beta binding [GO:0001540]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; structural constituent of eye lens [GO:0005212]; structural molecule activity [GO:0005198]; unfolded protein binding [GO:0051082] | 26145.01428546165 | 0.201003197245257 | 0.573635165409688 | 0.92951367659301 |
| Q9UEW8 | Q9UEW8 | STK39_HUMAN | STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39) | STK39 | cell volume homeostasis [GO:0006884]; cellular hyperosmotic response [GO:0071474]; cellular hypotonic response [GO:0071476]; cellular response to chemokine [GO:1990869]; cellular response to potassium ion [GO:0035865]; chemokine (C-X-C motif) ligand 12 signaling pathway [GO:0038146]; inflammatory response [GO:0006954]; intracellular chloride ion homeostasis [GO:0030644]; intracellular signal transduction [GO:0035556]; macrophage activation [GO:0042116]; maintenance of lens transparency [GO:0036438]; negative regulation of creatine transmembrane transporter activity [GO:1905408]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of T cell chemotaxis [GO:0010820]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of blood pressure [GO:0008217]; regulation of inflammatory response [GO:0050727]; renal sodium ion absorption [GO:0070294]; response to aldosterone [GO:1904044]; response to dietary excess [GO:0002021]; signal transduction [GO:0007165]; sodium ion transmembrane transport [GO:0035725] | apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell body [GO:0044297]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] | ATP binding [GO:0005524]; kinase activity [GO:0016301]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | 8241.72243649832 | 0.334035843760461 | 0.573686785571083 | 0.92951367659301 |
| P53367 | P53367 | ARFP1_HUMAN | Arfaptin-1 (ADP-ribosylation factor-interacting protein 1) | ARFIP1 | intracellular protein transport [GO:0006886]; negative regulation of retrograde transport, endosome to Golgi [GO:1905280]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of protein secretion [GO:0050708] | cytosol [GO:0005829]; Golgi membrane [GO:0000139]; trans-Golgi network membrane [GO:0032588] | phosphatidylinositol-4-phosphate binding [GO:0070273]; phospholipid binding [GO:0005543]; protein domain specific binding [GO:0019904] | 29619.2493796137 | 0.133167544201638 | 0.575314639706433 | 0.930463945715747 |
| Q7L7V1 | Q7L7V1 | DHX32_HUMAN | Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 (EC 3.6.4.13) (DEAD/H box 32) (DEAD/H helicase-like protein 1) (DHLP1) (DEAH box protein 32) (HuDDX32) | DHX32 | mitochondrion [GO:0005739]; spliceosomal complex [GO:0005681] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] | 1071.581515530105 | -0.282908941903327 | 0.574776769822491 | 0.930463945715747 | |
| Q658Y4 | Q658Y4 | F91A1_HUMAN | Protein FAM91A1 | FAM91A1 | intracellular protein transport [GO:0006886]; vesicle tethering to Golgi [GO:0099041] | cytoplasmic vesicle [GO:0031410]; trans-Golgi network [GO:0005802] | 7471.686903384725 | -0.124661679344286 | 0.575422814293678 | 0.930463945715747 | |
| Q9H9J2 | Q9H9J2 | RM44_HUMAN | Large ribosomal subunit protein mL44 (EC 3.1.26.-) (39S ribosomal protein L44, mitochondrial) (L44mt) (MRP-L44) | MRPL44 | mitochondrial translation [GO:0032543]; mitochondrial translational elongation [GO:0070125]; RNA processing [GO:0006396] | microprocessor complex [GO:0070877]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | double-stranded RNA binding [GO:0003725]; endonuclease activity [GO:0004519]; RNA binding [GO:0003723] | 5623.24968529307 | -0.0823532759010504 | 0.575205281866634 | 0.930463945715747 |
| Q5PRF9 | Q5PRF9 | SMAG2_HUMAN | Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B) | SAMD4B | nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289] | cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932] | mRNA binding [GO:0003729]; RNA binding [GO:0003723]; translation repressor activity [GO:0030371] | 2476.33045753555 | 0.925027287880298 | 0.574591956587669 | 0.930463945715747 |
| O75896 | O75896 | TUSC2_HUMAN | Tumor suppressor candidate 2 (Fusion 1 protein) (Fus-1 protein) (PDGFA-associated protein 2) | TUSC2 | cell cycle [GO:0007049]; cell maturation [GO:0048469]; inflammatory response [GO:0006954]; natural killer cell differentiation [GO:0001779]; negative regulation of interleukin-17 production [GO:0032700]; neutrophil-mediated killing of gram-negative bacterium [GO:0070945]; phagocytosis [GO:0006909]; positive regulation of interleukin-10 production [GO:0032733]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of reactive oxygen species metabolic process [GO:2000377] | mitochondrion [GO:0005739] | 6537.762409942519 | 0.502840215033334 | 0.575168908668441 | 0.930463945715747 | |
| P83876 | P83876 | TXN4A_HUMAN | Thioredoxin-like protein 4A (DIM1 protein homolog) (Spliceosomal U5 snRNP-specific 15 kDa protein) (Thioredoxin-like U5 snRNP protein U5-15kD) | TXNL4A | cell cycle [GO:0007049]; cell division [GO:0051301]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal complex assembly [GO:0000245] | cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682] | 12139.27018535445 | 0.123049281071101 | 0.574834265994644 | 0.930463945715747 | |
| O75607 | O75607 | NPM3_HUMAN | Nucleoplasmin-3 | NPM3 | chromatin remodeling [GO:0006338]; rRNA processing [GO:0006364]; rRNA transcription [GO:0009303] | actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] | chromatin binding [GO:0003682]; histone binding [GO:0042393]; RNA binding [GO:0003723] | 16500.054912660948 | 0.164046371921751 | 0.575681661067799 | 0.930616916293909 |
| Q9UBQ7 | Q9UBQ7 | GRHPR_HUMAN | Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.79) (EC 1.1.1.81) | GRHPR | carboxylic acid metabolic process [GO:0019752]; dicarboxylic acid metabolic process [GO:0043648]; glyoxylate metabolic process [GO:0046487] | catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; peroxisomal matrix [GO:0005782] | carboxylic acid binding [GO:0031406]; glycerate dehydrogenase activity [GO:0008465]; glyoxylate reductase (NADP+) activity [GO:0030267]; hydroxypyruvate reductase activity [GO:0016618]; NAD binding [GO:0051287]; NADPH binding [GO:0070402]; protein homodimerization activity [GO:0042803] | 31719.22785827205 | -0.13192529721769 | 0.576346410384955 | 0.930629456039087 |
| Q9UIW2 | Q9UIW2 | PLXA1_HUMAN | Plexin-A1 (Semaphorin receptor NOV) | PLXNA1 | dichotomous subdivision of terminal units involved in salivary gland branching [GO:0060666]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; negative regulation of cell adhesion [GO:0007162]; neuron projection extension [GO:1990138]; olfactory nerve formation [GO:0021628]; positive regulation of axonogenesis [GO:0050772]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of smooth muscle cell migration [GO:0014910]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116] | semaphorin receptor activity [GO:0017154] | 5886.437902355065 | -0.156456272157074 | 0.576216818644453 | 0.930629456039087 |
| O60678 | O60678 | ANM3_HUMAN | Protein arginine N-methyltransferase 3 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3) | PRMT3 | methylation [GO:0032259]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of retinoic acid biosynthetic process [GO:1900053] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] | metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; protein-arginine omega-N monomethyltransferase activity [GO:0035241]; ribosome binding [GO:0043022] | 2367.842911857985 | -0.728015749075953 | 0.575858803823977 | 0.930629456039087 |
| P51608 | P51608 | MECP2_HUMAN | Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) | MECP2 | adult locomotory behavior [GO:0008344]; behavioral fear response [GO:0001662]; biogenic amine metabolic process [GO:0006576]; cardiolipin metabolic process [GO:0032048]; catecholamine secretion [GO:0050432]; cellular response to isoquinoline alkaloid [GO:0071317]; cellular response to potassium ion [GO:0035865]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; dendrite development [GO:0016358]; excitatory postsynaptic potential [GO:0060079]; gene expression [GO:0010467]; genomic imprinting [GO:0071514]; glial cell proliferation [GO:0014009]; glucocorticoid metabolic process [GO:0008211]; glutamine metabolic process [GO:0006541]; heterochromatin formation [GO:0031507]; hippocampus development [GO:0021766]; inositol metabolic process [GO:0006020]; long-term memory [GO:0007616]; long-term synaptic potentiation [GO:0060291]; lung alveolus development [GO:0048286]; negative regulation of angiogenesis [GO:0016525]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of dendrite extension [GO:1903860]; negative regulation of dendritic spine development [GO:0061000]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of gene expression via chromosomal CpG dinucleotide methylation [GO:0044027]; negative regulation of locomotion involved in locomotory behavior [GO:0090327]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of primary miRNA processing [GO:2000635]; negative regulation of respiratory gaseous exchange [GO:1903941]; negative regulation of smooth muscle cell differentiation [GO:0051151]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system process involved in regulation of systemic arterial blood pressure [GO:0001976]; neuron maturation [GO:0042551]; Notch signaling pathway [GO:0007219]; olfactory bulb development [GO:0021772]; oligodendrocyte development [GO:0014003]; phosphatidylcholine metabolic process [GO:0046470]; positive regulation of anterograde dense core granule transport [GO:1901953]; positive regulation of branching morphogenesis of a nerve [GO:1905492]; positive regulation of dendrite extension [GO:1903861]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of microtubule nucleation [GO:0090063]; positive regulation of retrograde dense core granule transport [GO:1901956]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; principal sensory nucleus of trigeminal nerve development [GO:0021740]; proprioception [GO:0019230]; protein localization [GO:0008104]; regulation of action potential firing threshold [GO:0099611]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of synapse organization [GO:0050807]; respiratory gaseous exchange by respiratory system [GO:0007585]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; response to hypoxia [GO:0001666]; response to ionizing radiation [GO:0010212]; response to lead ion [GO:0010288]; response to other organism [GO:0051707]; sensory perception of pain [GO:0019233]; social behavior [GO:0035176]; spinal cord development [GO:0021510]; startle response [GO:0001964]; striatum development [GO:0021756]; synapse assembly [GO:0007416]; thalamus development [GO:0021794]; trans-synaptic signaling by BDNF [GO:0099191]; ventricular cardiac muscle tissue development [GO:0003229]; ventricular system development [GO:0021591]; visual learning [GO:0008542] | centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794] | chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; double-stranded methylated DNA binding [GO:0010385]; four-way junction DNA binding [GO:0000400]; histone deacetylase binding [GO:0042826]; histone reader activity [GO:0140566]; identical protein binding [GO:0042802]; methyl-CpG binding [GO:0008327]; molecular adaptor activity [GO:0060090]; molecular condensate scaffold activity [GO:0140693]; mRNA binding [GO:0003729]; nucleic acid binding [GO:0003676]; promoter-specific chromatin binding [GO:1990841]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; siRNA binding [GO:0035197]; transcription corepressor activity [GO:0003714]; unmethylated CpG binding [GO:0045322] | 12563.2117013762 | 0.169603159304303 | 0.577424645295126 | 0.931839373466872 |
| Q13555 | Q13555 | KCC2G_HUMAN | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | CAMK2G | cell differentiation [GO:0030154]; insulin secretion [GO:0030073]; nervous system development [GO:0007399]; phosphorylation [GO:0016310]; regulation of calcium ion transport [GO:0051924]; regulation of neuron projection development [GO:0010975]; regulation of skeletal muscle adaptation [GO:0014733] | calcium- and calmodulin-dependent protein kinase complex [GO:0005954]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; sarcoplasmic reticulum membrane [GO:0033017] | ATP binding [GO:0005524]; calcium-dependent protein serine/threonine phosphatase activity [GO:0004723]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310] | 11880.67093449755 | 0.0960106269675656 | 0.578092623391916 | 0.932651709606662 |
| P09651 | P09651 | ROA1_HUMAN | Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed] | HNRNPA1 | cellular response to glucose starvation [GO:0042149]; cellular response to sodium arsenite [GO:1903936]; import into nucleus [GO:0051170]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transport [GO:0051028]; negative regulation of telomere maintenance via telomerase [GO:0032211]; nuclear export [GO:0051168]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; RNA export from nucleus [GO:0006405] | catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681] | DNA binding [GO:0003677]; G-rich strand telomeric DNA binding [GO:0098505]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; mRNA 3'-UTR binding [GO:0003730]; pre-mRNA binding [GO:0036002]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; telomeric repeat-containing RNA binding [GO:0061752] | 99181.66900992114 | 0.141752820779905 | 0.580064584828334 | 0.935246207446875 |
| Q9H0F6 | Q9H0F6 | SHRPN_HUMAN | Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1) | SHARPIN | apoptotic nuclear changes [GO:0030262]; defense response to bacterium [GO:0042742]; keratinization [GO:0031424]; mitochondrion organization [GO:0007005]; negative regulation of inflammatory response [GO:0050728]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein linear polyubiquitination [GO:0097039]; regulation of CD40 signaling pathway [GO:2000348]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803] | cytosol [GO:0005829]; dendrite [GO:0030425]; LUBAC complex [GO:0071797]; synapse [GO:0045202] | identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin binding [GO:0043130]; ubiquitin-protein transferase activity [GO:0004842] | 8527.629756712975 | 0.535566998179733 | 0.580195979381533 | 0.935246207446875 |
| Q86WJ1 | Q86WJ1 | CHD1L_HUMAN | Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.-) (Amplified in liver cancer protein 1) | CHD1L | chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; DNA repair [GO:0006281] | cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA helicase activity [GO:0003678]; histone reader activity [GO:0140566]; nucleosome binding [GO:0031491]; nucleotide binding [GO:0000166]; poly-ADP-D-ribose modification-dependent protein binding [GO:0160004] | 5066.221466465705 | 0.263496154322937 | 0.580975348241589 | 0.93547921673136 |
| Q08554 | Q08554 | DSC1_HUMAN | Desmocollin-1 (Cadherin family member 1) (Desmosomal glycoprotein 2/3) (DG2/DG3) | DSC1 | adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; sprouting angiogenesis [GO:0002040] | adherens junction [GO:0005912]; catenin complex [GO:0016342]; cornified envelope [GO:0001533]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; gap junction [GO:0005921]; membrane [GO:0016020]; plasma membrane [GO:0005886] | cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] | 5911.51530235827 | -0.9967302706038 | 0.581166050634378 | 0.93547921673136 |
| Q14684 | Q14684 | RRP1B_HUMAN | Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) | RRP1B | apoptotic process [GO:0006915]; cellular response to virus [GO:0098586]; mRNA processing [GO:0006397]; negative regulation of GTPase activity [GO:0034260]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of apoptotic process [GO:0043065]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; rRNA processing [GO:0006364] | chromosome [GO:0005694]; cytosol [GO:0005829]; euchromatin [GO:0000791]; granular component [GO:0001652]; heterochromatin [GO:0000792]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, small subunit precursor [GO:0030688] | RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713] | 5685.052656018061 | -0.161698671040035 | 0.580625045462594 | 0.93547921673136 |
| O95292 | O95292 | VAPB_HUMAN | Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C) | VAPB | cholesterol transport [GO:0030301]; COPII-coated vesicle budding [GO:0090114]; endoplasmic reticulum membrane organization [GO:0090158]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endoplasmic reticulum unfolded protein response [GO:0030968]; endoplasmic reticulum-plasma membrane tethering [GO:0061817]; intracellular calcium ion homeostasis [GO:0006874]; IRE1-mediated unfolded protein response [GO:0036498]; modulation by host of viral RNA genome replication [GO:0044830]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation by virus of viral protein levels in host cell [GO:0046725]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation of viral genome replication [GO:0045070]; suppression of viral release by host [GO:0044790]; viral release from host cell [GO:0019076] | cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] | beta-tubulin binding [GO:0048487]; cadherin binding [GO:0045296]; enzyme binding [GO:0019899]; FFAT motif binding [GO:0033149]; microtubule binding [GO:0008017]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] | 64980.1726697021 | 0.15906271891944 | 0.581062094129369 | 0.93547921673136 |
| P55072 | P55072 | TERA_HUMAN | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | VCP | activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; aggresome assembly [GO:0070842]; ATP metabolic process [GO:0046034]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cellular response to arsenite ion [GO:1903843]; cellular response to heat [GO:0034605]; cellular response to misfolded protein [GO:0071218]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; endoplasmic reticulum stress-induced pre-emptive quality control [GO:0061857]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endoplasmic reticulum unfolded protein response [GO:0030968]; endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; ERAD pathway [GO:0036503]; establishment of protein localization [GO:0045184]; flavin adenine dinucleotide catabolic process [GO:0072389]; interstrand cross-link repair [GO:0036297]; macroautophagy [GO:0016236]; mitotic spindle disassembly [GO:0051228]; NADH metabolic process [GO:0006734]; negative regulation of protein localization to chromatin [GO:0120186]; negative regulation of smoothened signaling pathway [GO:0045879]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of Lys63-specific deubiquitinase activity [GO:1903007]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of oxidative phosphorylation [GO:1903862]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein K63-linked deubiquitination [GO:1903006]; positive regulation of protein-containing complex assembly [GO:0031334]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; protein-DNA covalent cross-linking repair [GO:0106300]; regulation of aerobic respiration [GO:1903715]; regulation of apoptotic process [GO:0042981]; regulation of protein localization to chromatin [GO:1905634]; regulation of synapse organization [GO:0050807]; retrograde protein transport, ER to cytosol [GO:0030970]; stress granule disassembly [GO:0035617]; translesion synthesis [GO:0019985]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral genome replication [GO:0019079] | ATPase complex [GO:1904949]; azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; Derlin-1 retrotranslocation complex [GO:0036513]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; proteasome complex [GO:0000502]; protein-containing complex [GO:0032991]; secretory granule lumen [GO:0034774]; site of double-strand break [GO:0035861]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]; VCP-NSFL1C complex [GO:1990730] | ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; BAT3 complex binding [GO:1904288]; deubiquitinase activator activity [GO:0035800]; identical protein binding [GO:0042802]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; lipid binding [GO:0008289]; MHC class I protein binding [GO:0042288]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein domain specific binding [GO:0019904]; protein phosphatase binding [GO:0019903]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-dependent protein binding [GO:0140036]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-specific protease binding [GO:1990381] | 152708.518541949 | 0.0738551146819188 | 0.581043022192001 | 0.93547921673136 |
| A6NDU8 | A6NDU8 | RIMC1_HUMAN | RAB7A-interacting MON1-CCZ1 complex subunit 1 (UPF0600 protein C5orf51) | RIMOC1 | mitophagy [GO:0000423] | cytosol [GO:0005829]; nucleoplasm [GO:0005654] | 7495.214392509395 | -0.266548288896737 | 0.581467134207442 | 0.935698035336372 | |
| Q6UWJ1 | Q6UWJ1 | TMCO3_HUMAN | Transmembrane and coiled-coil domain-containing protein 3 (Putative LAG1-interacting protein) | TMCO3 | membrane [GO:0016020] | potassium:proton antiporter activity [GO:0015386] | 10561.09524080806 | -0.17298853926822 | 0.581766131729857 | 0.935913373759617 | |
| Q15629 | Q15629 | TRAM1_HUMAN | Translocating chain-associated membrane protein 1 (Protein TRAM1) | TRAM1 | cotranslational protein targeting to membrane [GO:0006613]; protein insertion into ER membrane [GO:0045048]; response to unfolded protein [GO:0006986]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] | signaling receptor activity [GO:0038023] | 59919.94420213225 | -0.131393053164507 | 0.582267327991008 | 0.936453783819771 |
| Q8N2G6 | Q8N2G6 | ZCH24_HUMAN | Zinc finger CCHC domain-containing protein 24 | ZCCHC24 | RNA binding [GO:0003723]; zinc ion binding [GO:0008270] | 5584.612898583609 | 0.468384515320193 | 0.582635973211052 | 0.93678076737055 | ||
| Q7Z3B4 | Q7Z3B4 | NUP54_HUMAN | Nucleoporin p54 (54 kDa nucleoporin) | NUP54 | mRNA transport [GO:0051028]; NLS-bearing protein import into nucleus [GO:0006607]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; protein localization to nuclear inner membrane [GO:0036228]; protein targeting [GO:0006605]; regulation of protein import into nucleus [GO:0042306] | nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore central transport channel [GO:0044613] | identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; structural constituent of nuclear pore [GO:0017056] | 12476.05554034745 | 0.20476416407612 | 0.583528068696314 | 0.937948946732855 |
| Q96ET8;Q9NYZ1 | Q96ET8 | TV23C_HUMAN | Golgi apparatus membrane protein TVP23 homolog C | TVP23C | protein secretion [GO:0009306]; vesicle-mediated transport [GO:0016192] | membrane [GO:0016020] | 17144.53179443125 | 0.226080237286669 | 0.583775055113871 | 0.938079824808619 | |
| Q10570 | Q10570 | CPSF1_HUMAN | Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit) | CPSF1 | co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180012]; mRNA polyadenylation [GO:0006378] | mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | enzyme binding [GO:0019899]; mRNA 3'-UTR AU-rich region binding [GO:0035925] | 5303.98802270773 | -0.286838197884952 | 0.585120400540348 | 0.93917625763785 |
| Q9UBU8 | Q9UBU8 | MO4L1_HUMAN | Mortality factor 4-like protein 1 (MORF-related gene 15 protein) (MRG15) (Protein MSL3-1) (Transcription factor-like protein MRG15) | MORF4L1 | chromatin organization [GO:0006325]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779] | NuA4 histone acetyltransferase complex [GO:0035267]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; Sin3-type complex [GO:0070822] | 6273.7434515387395 | 0.163542943612004 | 0.584881787931657 | 0.93917625763785 | |
| Q5EBL8 | Q5EBL8 | PDZ11_HUMAN | PDZ domain-containing protein 11 (ATPase-interacting PDZ protein) (Plasma membrane calcium ATPase-interacting single-PDZ protein) (PMCA-interacting single-PDZ protein) | PDZD11 | maintenance of epithelial cell apical/basal polarity [GO:0045199]; neurotransmitter secretion [GO:0007269]; pore complex assembly [GO:0046931]; protein localization to basolateral plasma membrane [GO:1903361] | adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; extracellular region [GO:0005576]; pore complex [GO:0046930]; presynapse [GO:0098793]; synapse [GO:0045202] | 4410.7274364067 | 0.36851953455016 | 0.584998491949796 | 0.93917625763785 | |
| Q01970 | Q01970 | PLCB3_HUMAN | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3) | PLCB3 | G protein-coupled receptor signaling pathway [GO:0007186]; lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; regulation of systemic arterial blood pressure [GO:0003073]; release of sequestered calcium ion into cytosol [GO:0051209] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]; protein-containing complex [GO:0032991] | cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; molecular adaptor activity [GO:0060090]; molecular function activator activity [GO:0140677]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629] | 11145.6428294703 | 0.216313293386114 | 0.584848159439515 | 0.93917625763785 |
| P40926 | P40926 | MDHM_HUMAN | Malate dehydrogenase, mitochondrial (EC 1.1.1.37) | MDH2 | aerobic respiration [GO:0009060]; gluconeogenesis [GO:0006094]; malate metabolic process [GO:0006108]; NADH metabolic process [GO:0006734]; oxaloacetate metabolic process [GO:0006107]; tricarboxylic acid cycle [GO:0006099] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634] | L-malate dehydrogenase activity [GO:0030060]; malate dehydrogenase (NADP+) activity [GO:0046554]; protein self-association [GO:0043621]; RNA binding [GO:0003723] | 343811.92100709653 | -0.0626896711795984 | 0.585433036155455 | 0.939282919953014 |
| Q9BPX7 | Q9BPX7 | CG025_HUMAN | UPF0415 protein C7orf25 | C7orf25 | 7500.57787943336 | 0.188855532350656 | 0.58575947662942 | 0.939403678058956 | |||
| Q9NVJ2 | Q9NVJ2 | ARL8B_HUMAN | ADP-ribosylation factor-like protein 8B (EC 3.6.5.2) (ADP-ribosylation factor-like protein 10C) (Novel small G protein indispensable for equal chromosome segregation 1) | ARL8B | anterograde axonal transport [GO:0008089]; antigen processing and presentation following phagocytosis [GO:0002747]; antigen processing and presentation of polysaccharide antigen via MHC class II [GO:0002505]; autophagosome-lysosome fusion [GO:0061909]; calcium ion regulated lysosome exocytosis [GO:1990927]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; endosomal transport [GO:0016197]; endosome to lysosome transport of low-density lipoprotein particle [GO:0090117]; late endosome to lysosome transport [GO:1902774]; lysosome localization [GO:0032418]; natural killer cell mediated cytotoxicity [GO:0042267]; phagosome-lysosome fusion [GO:0090385]; plasma membrane repair [GO:0001778]; protein transport [GO:0015031]; viral exocytosis [GO:0046754] | axon cytoplasm [GO:1904115]; cytolytic granule membrane [GO:0101004]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; midbody [GO:0030496]; spindle midzone [GO:0051233]; synapse [GO:0045202] | alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] | 69815.66239166609 | -0.0792654953191202 | 0.586649028572464 | 0.940297990351226 |
| Q13049 | Q13049 | TRI32_HUMAN | E3 ubiquitin-protein ligase TRIM32 (EC 2.3.2.27) (72 kDa Tat-interacting protein) (RING-type E3 ubiquitin transferase TRIM32) (Tripartite motif-containing protein 32) (Zinc finger protein HT2A) | TRIM32 | actin ubiquitination [GO:0007014]; axon development [GO:0061564]; fat cell differentiation [GO:0045444]; free ubiquitin chain polymerization [GO:0010994]; innate immune response [GO:0045087]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of cilium assembly [GO:1902018]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell motility [GO:2000147]; positive regulation of chemokine (C-C motif) ligand 20 production [GO:1903886]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of interleukin-17-mediated signaling pathway [GO:1903883]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of proteolysis [GO:0045862]; positive regulation of striated muscle cell differentiation [GO:0051155]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; response to oxidative stress [GO:0006979]; response to starvation [GO:0042594]; response to tumor necrosis factor [GO:0034612]; response to UV [GO:0009411]; suppression of viral release by host [GO:0044790]; tissue homeostasis [GO:0001894]; ubiquitin-dependent protein catabolic process [GO:0006511] | autophagosome [GO:0005776]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; striated muscle myosin thick filament [GO:0005863] | identical protein binding [GO:0042802]; myosin binding [GO:0017022]; protein self-association [GO:0043621]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]; Tat protein binding [GO:0030957]; transcription coactivator activity [GO:0003713]; translation initiation factor binding [GO:0031369]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] | 3073.830365470275 | -0.428997564912579 | 0.586614521916781 | 0.940297990351226 |
| P55196 | P55196 | AFAD_HUMAN | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | AFDN | bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell signaling [GO:0007267]; establishment of endothelial intestinal barrier [GO:0090557]; establishment of protein localization to plasma membrane [GO:0061951]; negative regulation of cell migration [GO:0030336]; pore complex assembly [GO:0046931]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of gene expression [GO:0010628]; regulation of protein localization [GO:0032880]; signal transduction [GO:0007165] | adherens junction [GO:0005912]; cell junction [GO:0030054]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; pore complex [GO:0046930]; tight junction [GO:0070160] | actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; small GTPase binding [GO:0031267] | 6955.8283411021 | 0.212712206184623 | 0.590000915968105 | 0.945135761909891 |
| Q96DX4 | Q96DX4 | RSPRY_HUMAN | RING finger and SPRY domain-containing protein 1 | RSPRY1 | proteolysis involved in protein catabolic process [GO:0051603] | cytoplasm [GO:0005737]; extracellular region [GO:0005576] | metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] | 15461.47424683155 | -0.148749207173783 | 0.590231132496683 | 0.945237308288922 |
| Q9H0S4 | Q9H0S4 | DDX47_HUMAN | Probable ATP-dependent RNA helicase DDX47 (EC 3.6.4.13) (DEAD box protein 47) | DDX47 | extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; rRNA processing [GO:0006364] | membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] | 3916.775663981285 | 0.166295250159349 | 0.592581445526542 | 0.947344872596626 |
| P50548 | P50548 | ERF_HUMAN | ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2) | ERF | cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357] | chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; sequence-specific DNA binding [GO:0043565] | 6034.825629425735 | -0.312888071771984 | 0.592453620271884 | 0.947344872596626 |
| O15235 | O15235 | RT12_HUMAN | Small ribosomal subunit protein uS12m (28S ribosomal protein S12, mitochondrial) (MRP-S12) (S12mt) (MT-RPS12) | MRPS12 | mitochondrial translation [GO:0032543]; translation [GO:0006412] | mitochondrial inner membrane [GO:0005743]; mitochondrial ribosome [GO:0005761]; mitochondrial small ribosomal subunit [GO:0005763]; ribosome [GO:0005840] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 8018.544575377105 | 0.168845086097035 | 0.592884736715078 | 0.947344872596626 |
| Q15742 | Q15742 | NAB2_HUMAN | NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER) | NAB2 | endochondral ossification [GO:0001958]; myelination [GO:0042552]; negative regulation of transcription by RNA polymerase III [GO:0016480]; regulation of DNA-templated transcription [GO:0006355]; regulation of epidermis development [GO:0045682]; Schwann cell differentiation [GO:0014037] | nucleoplasm [GO:0005654]; nucleus [GO:0005634] | identical protein binding [GO:0042802]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714] | 4033.18832529629 | 0.178307765385871 | 0.592038851148263 | 0.947344872596626 |
| Q7Z7A4 | Q7Z7A4 | PXK_HUMAN | PX domain-containing protein kinase-like protein (Modulator of Na,K-ATPase) (MONaKA) | PXK | early endosome to late endosome transport [GO:0045022]; endosome to lysosome transport [GO:0008333]; inflammatory response [GO:0006954]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of monoatomic ion transport [GO:0043271]; protein targeting to lysosome [GO:0006622] | centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; late endosome [GO:0005770]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] | actin binding [GO:0003779]; phosphatidylinositol binding [GO:0035091] | 9255.712277093164 | -0.167927499428107 | 0.592350605199291 | 0.947344872596626 |
| Q13148 | Q13148 | TADBP_HUMAN | TAR DNA-binding protein 43 (TDP-43) | TARDBP | 3'-UTR-mediated mRNA destabilization [GO:0061158]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; amyloid fibril formation [GO:1990000]; mRNA processing [GO:0006397]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of gene expression [GO:0010629]; negative regulation of protein phosphorylation [GO:0001933]; nuclear inner membrane organization [GO:0071765]; positive regulation of insulin secretion [GO:0032024]; positive regulation of protein import into nucleus [GO:0042307]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of circadian rhythm [GO:0042752]; regulation of gene expression [GO:0010468]; regulation of protein stability [GO:0031647]; response to endoplasmic reticulum stress [GO:0034976]; rhythmic process [GO:0048511]; RNA splicing [GO:0008380] | cytoplasmic stress granule [GO:0010494]; interchromatin granule [GO:0035061]; intracellular non-membrane-bounded organelle [GO:0043232]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726] | DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR binding [GO:0003730]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] | 31355.3288425102 | 0.0955791723677887 | 0.592624860718728 | 0.947344872596626 |
| Q9BXJ8 | Q9BXJ8 | TACAN_HUMAN | Ion channel TACAN (Transmembrane protein 120A) (Transmembrane protein induced by tumor necrosis factor alpha) | TMEM120A | detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; fat cell differentiation [GO:0045444]; monoatomic ion transmembrane transport [GO:0034220]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260] | membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; plasma membrane [GO:0005886] | monoatomic ion channel activity [GO:0005216] | 21189.469068102553 | -0.216388123587026 | 0.592857559239534 | 0.947344872596626 |
| O00148 | O00148 | DX39A_HUMAN | ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) (Nuclear RNA helicase URH49) | DDX39A | mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; RNA export from nucleus [GO:0006405] | cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] | 12295.7611953571 | 0.129714821068511 | 0.59364289414102 | 0.94755515608296 |
| P33316 | P33316 | DUT_HUMAN | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase) | DUT | DNA replication [GO:0006260]; dTMP biosynthetic process [GO:0006231]; dUMP biosynthetic process [GO:0006226]; dUTP catabolic process [GO:0046081]; nucleobase-containing compound metabolic process [GO:0006139] | extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | dUTP diphosphatase activity [GO:0004170]; magnesium ion binding [GO:0000287]; RNA binding [GO:0003723] | 14046.9571396341 | 0.203127607118366 | 0.593831379750779 | 0.94755515608296 |
| Q8IXK0 | Q8IXK0 | PHC2_HUMAN | Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2) | PHC2 | negative regulation of DNA-templated transcription [GO:0045892]; spermatogenesis [GO:0007283] | heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102] | chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270] | 6862.404443310155 | 0.19907219466742 | 0.593558202063589 | 0.94755515608296 |
| Q9NX57 | Q9NX57 | RAB20_HUMAN | Ras-related protein Rab-20 | RAB20 | cellular response to type II interferon [GO:0071346]; intracellular protein transport [GO:0006886]; phagosome acidification [GO:0090383]; phagosome-lysosome fusion [GO:0090385] | endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670] | GTP binding [GO:0005525]; GTPase activity [GO:0003924] | 3885.13486881286 | -2.32933882036046 | 0.593852516634414 | 0.94755515608296 |
| O60220 | O60220 | TIM8A_HUMAN | Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1) (X-linked deafness dystonia protein) | TIMM8A | nervous system development [GO:0007399]; protein insertion into mitochondrial inner membrane [GO:0045039] | mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial intermembrane space protein transporter complex [GO:0042719]; mitochondrion [GO:0005739] | identical protein binding [GO:0042802]; zinc ion binding [GO:0008270] | 19308.532943671198 | 0.0589428885547723 | 0.594096025077396 | 0.947676823786183 |
| O95376 | O95376 | ARI2_HUMAN | E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (EC 2.3.2.31) (RING-type E3 ubiquitin transferase ARIH2) (Triad1 protein) | ARIH2 | developmental cell growth [GO:0048588]; hematopoietic stem cell proliferation [GO:0071425]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] | cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] | ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] | 5902.17601396372 | -0.134936120996642 | 0.59466651416853 | 0.948053030185395 |
| O75146 | O75146 | HIP1R_HUMAN | Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12) | HIP1R | actin filament organization [GO:0007015]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; clathrin coat assembly [GO:0048268]; digestive system development [GO:0055123]; endocytosis [GO:0006897]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of apoptotic process [GO:0043066]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; positive regulation of apoptotic process [GO:0043065]; positive regulation of clathrin coat assembly [GO:1905445]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000588]; positive regulation of protein binding [GO:0032092]; postsynapse organization [GO:0099173]; protein stabilization [GO:0050821]; receptor-mediated endocytosis [GO:0006898]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of clathrin-dependent endocytosis [GO:2000369]; regulation of endocytosis [GO:0030100]; regulation of gastric acid secretion [GO:0060453] | apical plasma membrane [GO:0016324]; cell cortex [GO:0005938]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; clathrin-coated vesicle membrane [GO:0030665]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; ruffle membrane [GO:0032587]; synaptic membrane [GO:0097060] | actin filament binding [GO:0051015]; clathrin adaptor activity [GO:0035615]; clathrin binding [GO:0030276]; clathrin light chain binding [GO:0032051]; identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; SH3 domain binding [GO:0017124] | 3836.367097450405 | -0.37738709621927 | 0.594541953788129 | 0.948053030185395 |
| Q01850 | Q01850 | CDR2_HUMAN | Cerebellar degeneration-related protein 2 (Major Yo paraneoplastic antigen) (Paraneoplastic cerebellar degeneration-associated antigen) | CDR2 | cytoplasm [GO:0005737] | 6440.283625704435 | 0.0958134569787236 | 0.595780650298784 | 0.949562071615446 | ||
| O43520 | O43520 | AT8B1_HUMAN | Phospholipid-transporting ATPase IC (EC 7.6.2.1) (ATPase class I type 8B member 1) (Familial intrahepatic cholestasis type 1) (P4-ATPase flippase complex alpha subunit ATP8B1) | ATP8B1 | apical protein localization [GO:0045176]; bile acid and bile salt transport [GO:0015721]; bile acid metabolic process [GO:0008206]; Golgi organization [GO:0007030]; inner ear receptor cell development [GO:0060119]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of DNA-templated transcription [GO:0045892]; phospholipid translocation [GO:0045332]; regulation of chloride transport [GO:2001225]; regulation of microvillus assembly [GO:0032534]; regulation of plasma membrane organization [GO:1903729]; sensory perception of sound [GO:0007605]; vestibulocochlear nerve formation [GO:0021650]; xenobiotic transmembrane transport [GO:0006855] | apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; trans-Golgi network [GO:0005802] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; cardiolipin binding [GO:1901612]; magnesium ion binding [GO:0000287]; phosphatidylcholine flippase activity [GO:0140345]; phosphatidylcholine floppase activity [GO:0090554]; phosphatidylserine flippase activity [GO:0140346]; phosphatidylserine floppase activity [GO:0090556] | 8021.145364455305 | -0.212461160688058 | 0.596940829449019 | 0.950608976857263 |
| Q86X02 | Q86X02 | CDR2L_HUMAN | Cerebellar degeneration-related protein 2-like (Paraneoplastic 62 kDa antigen) | CDR2L | Golgi to secretory granule transport [GO:0055107]; vesicle transport along microtubule [GO:0047496] | cytoplasm [GO:0005737] | identical protein binding [GO:0042802] | 10142.30968639465 | -0.204253354267892 | 0.596876670339679 | 0.950608976857263 |
| P10768 | P10768 | ESTD_HUMAN | S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase D) (Methylumbelliferyl-acetate deacetylase) (EC 3.1.1.56) | ESD | formaldehyde catabolic process [GO:0046294] | cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062] | carboxylic ester hydrolase activity [GO:0052689]; hydrolase activity, acting on ester bonds [GO:0016788]; identical protein binding [GO:0042802]; methylumbelliferyl-acetate deacetylase activity [GO:0047374]; S-formylglutathione hydrolase activity [GO:0018738] | 71186.05529982591 | 0.110581735096432 | 0.596794034220141 | 0.950608976857263 |
| Q8IYI6 | Q8IYI6 | EXOC8_HUMAN | Exocyst complex component 8 (Exocyst complex 84 kDa subunit) | EXOC8 | endosome organization [GO:0007032]; exocytosis [GO:0006887]; extracellular matrix disassembly [GO:0022617]; Golgi to plasma membrane transport [GO:0006893]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; protein localization [GO:0008104]; protein transport [GO:0015031]; regulation of macroautophagy [GO:0016241]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522] | cell leading edge [GO:0031252]; cytosol [GO:0005829]; exocyst [GO:0000145]; growth cone [GO:0030426]; late endosome [GO:0005770]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] | phosphatidylinositol binding [GO:0035091]; small GTPase binding [GO:0031267] | 8976.07092216635 | -0.135168952271658 | 0.597422224334639 | 0.950768504265226 |
| Q14683 | Q14683 | SMC1A_HUMAN | Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8) | SMC1A | cell division [GO:0051301]; DNA repair [GO:0006281]; establishment of meiotic sister chromatid cohesion [GO:0034089]; establishment of mitotic sister chromatid cohesion [GO:0034087]; meiotic cell cycle [GO:0051321]; mitotic sister chromatid cohesion [GO:0007064]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly [GO:0090307]; response to DNA damage checkpoint signaling [GO:0072423]; response to radiation [GO:0009314]; sister chromatid cohesion [GO:0007062]; somatic stem cell population maintenance [GO:0035019] | chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; kinetochore [GO:0000776]; meiotic cohesin complex [GO:0030893]; mitotic cohesin complex [GO:0030892]; mitotic spindle pole [GO:0097431]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; mediator complex binding [GO:0036033]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723] | 5192.399314526365 | -0.148323666783971 | 0.597544412934781 | 0.950768504265226 |
| Q14160 | Q14160 | SCRIB_HUMAN | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | SCRIB | activation of GTPase activity [GO:0090630]; apoptotic process involved in morphogenesis [GO:0060561]; astrocyte cell migration [GO:0043615]; auditory receptor cell stereocilium organization [GO:0060088]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; cell-cell adhesion [GO:0098609]; cochlear nucleus development [GO:0021747]; establishment of apical/basal cell polarity [GO:0035089]; establishment of T cell polarity [GO:0001768]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; mammary gland duct morphogenesis [GO:0060603]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of mitotic cell cycle [GO:0045930]; neural tube closure [GO:0001843]; neurotransmitter receptor transport postsynaptic membrane to endosome [GO:0098968]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; polarized epithelial cell differentiation [GO:0030859]; positive chemotaxis [GO:0050918]; positive regulation of apoptotic process [GO:0043065]; positive regulation of receptor recycling [GO:0001921]; positive regulation of type II interferon production [GO:0032729]; post-anal tail morphogenesis [GO:0036342]; protein localization to adherens junction [GO:0071896]; receptor clustering [GO:0043113]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle targeting [GO:0016080]; wound healing [GO:0042060] | adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; extrinsic component of postsynaptic density membrane [GO:0099147]; glutamatergic synapse [GO:0098978]; immunological synapse [GO:0001772]; lamellipodium [GO:0030027]; myelin sheath abaxonal region [GO:0035748]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; Scrib-APC-beta-catenin complex [GO:0034750] | cadherin binding [GO:0045296]; signaling adaptor activity [GO:0035591] | 7056.5573208131245 | -0.300238657836375 | 0.59795137821513 | 0.951148935700991 |
| Q5TGL8 | Q5TGL8 | PXDC1_HUMAN | PX domain-containing protein 1 | PXDC1 | phosphatidylinositol binding [GO:0035091] | 10649.412139582651 | 0.136479545196956 | 0.598165802387887 | 0.951222968377706 | ||
| Q6UWP7 | Q6UWP7 | LCLT1_HUMAN | Lysocardiolipin acyltransferase 1 (EC 2.3.1.-) (1-acylglycerol-3-phosphate O-acyltransferase 8) (1-AGP acyltransferase 8) (1-AGPAT 8) (EC 2.3.1.51) (Acyl-CoA:lysocardiolipin acyltransferase 1) | LCLAT1 | cardiolipin acyl-chain remodeling [GO:0035965]; CDP-diacylglycerol biosynthetic process [GO:0016024]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylinositol acyl-chain remodeling [GO:0036149] | cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] | 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; acyltransferase activity [GO:0016746]; O-acyltransferase activity [GO:0008374] | 7784.974735555044 | 0.183244010875379 | 0.598648819170858 | 0.95172396448431 |
| O15234 | O15234 | CASC3_HUMAN | Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz) | CASC3 | intracellular mRNA localization [GO:0008298]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000622]; regulation of translation [GO:0006417] | cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; exon-exon junction complex [GO:0035145]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; U2-type catalytic step 1 spliceosome [GO:0071006] | enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625] | 4098.8001388076245 | 0.147332030541204 | 0.599355778775564 | 0.952580600993645 |
| Q8TCS8 | Q8TCS8 | PNPT1_HUMAN | Polyribonucleotide nucleotidyltransferase 1, mitochondrial (EC 2.7.7.8) (3'-5' RNA exonuclease OLD35) (PNPase old-35) (Polynucleotide phosphorylase 1) (PNPase 1) (Polynucleotide phosphorylase-like protein) | PNPT1 | cellular response to interferon-beta [GO:0035458]; cellular response to oxidative stress [GO:0034599]; liver regeneration [GO:0097421]; mitochondrial mRNA catabolic process [GO:0000958]; mitochondrial mRNA polyadenylation [GO:0097222]; mitochondrial RNA 3'-end processing [GO:0000965]; mitochondrial RNA 5'-end processing [GO:0000964]; mitochondrial RNA catabolic process [GO:0000957]; mitochondrion organization [GO:0007005]; mRNA catabolic process [GO:0006402]; mRNA processing [GO:0006397]; negative regulation of growth [GO:0045926]; nuclear polyadenylation-dependent mRNA catabolic process [GO:0071042]; positive regulation of miRNA catabolic process [GO:2000627]; positive regulation of mitochondrial RNA catabolic process [GO:0000962]; positive regulation of mRNA catabolic process [GO:0061014]; protein homooligomerization [GO:0051260]; protein homotrimerization [GO:0070207]; regulation of cell cycle [GO:0051726]; regulation of cellular respiration [GO:0043457]; regulation of cellular senescence [GO:2000772]; response to cAMP [GO:0051591]; response to growth hormone [GO:0060416]; RNA catabolic process [GO:0006401]; RNA import into mitochondrion [GO:0035927]; rRNA import into mitochondrion [GO:0035928] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial degradosome [GO:0045025]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ribosome [GO:0005840] | 3'-5'-RNA exonuclease activity [GO:0000175]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; polyribonucleotide nucleotidyltransferase activity [GO:0004654]; RNA binding [GO:0003723] | 9239.143397804753 | 0.0745015116214083 | 0.599744001543578 | 0.952930317651685 |
| P19532 | P19532 | TFE3_HUMAN | Transcription factor E3 (Class E basic helix-loop-helix protein 33) (bHLHe33) | TFE3 | adaptive immune response [GO:0002250]; humoral immune response [GO:0006959]; lysosome organization [GO:0007040]; negative regulation of cold-induced thermogenesis [GO:0120163]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cell adhesion [GO:0045785]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of osteoclast differentiation [GO:0045670]; regulation of transcription by RNA polymerase II [GO:0006357] | chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976] | 11820.8228848463 | -0.282840770747654 | 0.600651523142798 | 0.953837312255352 |
| Q00613 | Q00613 | HSF1_HUMAN | Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1) | HSF1 | cellular response to angiotensin [GO:1904385]; cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to diamide [GO:0072738]; cellular response to estradiol stimulus [GO:0071392]; cellular response to gamma radiation [GO:0071480]; cellular response to heat [GO:0034605]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to L-glutamine [GO:1904845]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to nitroglycerin [GO:1904843]; cellular response to potassium ion [GO:0035865]; cellular response to sodium arsenite [GO:1903936]; cellular response to unfolded protein [GO:0034620]; cellular response to xenobiotic stimulus [GO:0071466]; defense response [GO:0006952]; DNA repair [GO:0006281]; MAPK cascade [GO:0000165]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]; negative regulation of gene expression [GO:0010629]; negative regulation of inclusion body assembly [GO:0090084]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic DNA fragmentation [GO:1902512]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of gene expression [GO:0010628]; positive regulation of inclusion body assembly [GO:0090261]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of stress granule assembly [GO:0062029]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein-containing complex assembly [GO:0065003]; regulation of cellular response to heat [GO:1900034]; regulation of transcription by RNA polymerase II [GO:0006357]; response to activity [GO:0014823]; response to hypobaric hypoxia [GO:1990910]; response to nutrient [GO:0007584]; response to psychosocial stress [GO:1990911]; response to testosterone [GO:0033574] | centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; kinetochore [GO:0000776]; mitotic spindle pole [GO:0097431]; nuclear stress granule [GO:0097165]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; PML body [GO:0016605]; protein folding chaperone complex [GO:0101031]; ribonucleoprotein complex [GO:1990904] | chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; general transcription initiation factor binding [GO:0140296]; heat shock protein binding [GO:0031072]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; promoter-specific chromatin binding [GO:1990841]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; protein self-association [GO:0043621]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; sequence-specific single stranded DNA binding [GO:0098847]; STAT family protein binding [GO:0097677]; transcription cis-regulatory region binding [GO:0000976]; translation elongation factor binding [GO:0061770] | 6966.65161448628 | 0.0366393278988042 | 0.60112634157855 | 0.954323858611394 |
| Q9BQ48 | Q9BQ48 | RM34_HUMAN | Large ribosomal subunit protein bL34m (39S ribosomal protein L34, mitochondrial) (L34mt) (MRP-L34) | MRPL34 | mitochondrial translation [GO:0032543]; translation [GO:0006412] | mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739] | structural constituent of ribosome [GO:0003735] | 17644.99205868995 | 0.168840122086462 | 0.601706691032597 | 0.954710196412964 |
| Q96GC9 | Q96GC9 | VMP1_HUMAN | Vacuole membrane protein 1 (Transmembrane protein 49) | VMP1 | autophagosome assembly [GO:0000045]; autophagosome membrane docking [GO:0016240]; autophagy [GO:0006914]; cell junction assembly [GO:0034329]; cell-cell adhesion [GO:0098609]; embryo implantation [GO:0007566]; Golgi organization [GO:0007030]; lipoprotein transport [GO:0042953]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; organelle localization by membrane tethering [GO:0140056]; positive regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901896] | autophagosome membrane [GO:0000421]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; membrane [GO:0016020]; nucleolus [GO:0005730]; phagophore assembly site [GO:0000407]; plasma membrane [GO:0005886] | phospholipid scramblase activity [GO:0017128] | 16267.854625949949 | 0.135302603845331 | 0.601574950282721 | 0.954710196412964 |
| Q6PCB7 | Q6PCB7 | S27A1_HUMAN | Long-chain fatty acid transport protein 1 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Fatty acid transport protein 1) (FATP-1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 1) (Very long-chain acyl-CoA synthetase) (EC 6.2.1.-) | SLC27A1 | adiponectin-activated signaling pathway [GO:0033211]; biotin import across plasma membrane [GO:1905135]; biotin transport [GO:0015878]; cardiolipin biosynthetic process [GO:0032049]; export across plasma membrane [GO:0140115]; glucose import in response to insulin stimulus [GO:0044381]; lipid transport across blood-brain barrier [GO:1990379]; long-chain fatty acid import across plasma membrane [GO:0015911]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty acid transport [GO:0015909]; medium-chain fatty acid transport [GO:0001579]; negative regulation of phospholipid biosynthetic process [GO:0071072]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylethanolamine biosynthetic process [GO:0006646]; phosphatidylglycerol biosynthetic process [GO:0006655]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylserine biosynthetic process [GO:0006659]; positive regulation of heat generation [GO:0031652]; positive regulation of triglyceride biosynthetic process [GO:0010867]; response to cold [GO:0009409]; transport across blood-brain barrier [GO:0150104] | basal plasma membrane [GO:0009925]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; plasma membrane [GO:0005886] | arachidonate-CoA ligase activity [GO:0047676]; biotin transmembrane transporter activity [GO:0015225]; efflux transmembrane transporter activity [GO:0015562]; fatty acid transmembrane transporter activity [GO:0015245]; identical protein binding [GO:0042802]; long-chain fatty acid transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; nucleotide binding [GO:0000166]; oleate transmembrane transporter activity [GO:1901480]; oleoyl-CoA ligase activity [GO:0090434]; protein serine/threonine kinase activator activity [GO:0043539]; very long-chain fatty acid-CoA ligase activity [GO:0031957] | 8687.254166384966 | -0.130651940201639 | 0.603443865895075 | 0.957198472609601 |
| Q68CP4 | Q68CP4 | HGNAT_HUMAN | Heparan-alpha-glucosaminide N-acetyltransferase (EC 2.3.1.78) (Transmembrane protein 76) | HGSNAT | heparan sulfate proteoglycan catabolic process [GO:0030200]; lysosomal transport [GO:0007041]; protein complex oligomerization [GO:0051259] | lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] | acyltransferase activity [GO:0016746]; heparan-alpha-glucosaminide N-acetyltransferase activity [GO:0015019] | 71225.47566950956 | -0.0771655827230701 | 0.603686622281095 | 0.957315533681692 |
| Q8IXL7 | Q8IXL7 | MSRB3_HUMAN | Methionine-R-sulfoxide reductase B3 (MsrB3) (EC 1.8.4.12) (EC 1.8.4.14) | MSRB3 | protein repair [GO:0030091]; response to oxidative stress [GO:0006979] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739] | L-methionine-(R)-S-oxide reductase activity [GO:0033745]; peptide-methionine (R)-S-oxide reductase activity [GO:0033743]; zinc ion binding [GO:0008270] | 9800.33260110112 | -0.180792410089298 | 0.604079693081252 | 0.957402948531014 |
| A5A3E0 | A5A3E0 | POTEF_HUMAN | POTE ankyrin domain family member F (ANKRD26-like family C member 1B) (Chimeric POTE-actin protein) | POTEF | axonogenesis [GO:0007409]; cell motility [GO:0048870] | actin filament [GO:0005884]; axon [GO:0030424]; blood microparticle [GO:0072562]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; NuA4 histone acetyltransferase complex [GO:0035267]; synapse [GO:0045202] | protein kinase binding [GO:0019901]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973] | 300589.33478660753 | -0.150958234232788 | 0.603920219859636 | 0.957402948531014 |
| Q9H078 | Q9H078 | CLPB_HUMAN | Mitochondrial disaggregase (EC 3.6.1.-) (Suppressor of potassium transport defect 3) [Cleaved into: Mitochondrial disaggregase, cleaved form] | CLPB | antiviral innate immune response [GO:0140374]; cellular response to heat [GO:0034605]; granulocyte differentiation [GO:0030851]; RIG-I signaling pathway [GO:0039529] | cytoplasm [GO:0005737]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein disaggregase activity [GO:0140545] | 8635.920631276771 | 0.185829983276853 | 0.604288491752 | 0.957466049850904 |
| Q8IV38 | Q8IV38 | ANKY2_HUMAN | Ankyrin repeat and MYND domain-containing protein 2 | ANKMY2 | cilium [GO:0005929] | enzyme binding [GO:0019899]; metal ion binding [GO:0046872] | 6397.197010554805 | 0.0960912954128478 | 0.605100825182064 | 0.958344336046916 | |
| Q969J3 | Q969J3 | BORC5_HUMAN | BLOC-1-related complex subunit 5 (Loss of heterozygosity 12 chromosomal region 1) (Myristoylated lysosomal protein) (Myrlysin) | BORCS5 | lysosome localization [GO:0032418]; organelle transport along microtubule [GO:0072384]; positive regulation of anterograde synaptic vesicle transport [GO:1903744]; regulation of endosome size [GO:0051036]; regulation of lysosome size [GO:0062196] | BORC complex [GO:0099078]; cytoplasmic side of lysosomal membrane [GO:0098574]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672] | 13001.0436052851 | -0.18003353692418 | 0.606403695256297 | 0.958344336046916 | |
| Q9BT78 | Q9BT78 | CSN4_HUMAN | COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4) | COPS4 | protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; regulation of protein neddylation [GO:2000434] | cell junction [GO:0030054]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synaptic vesicle [GO:0008021] | deNEDDylase activity [GO:0019784] | 35880.7629421115 | -0.0501812230503127 | 0.605474681513281 | 0.958344336046916 |
| O43586 | O43586 | PPIP1_HUMAN | Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP) | PSTPIP1 | actin filament polymerization [GO:0030041]; cell adhesion [GO:0007155]; endocytosis [GO:0006897]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; signal transduction [GO:0007165] | actin filament [GO:0005884]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; uropod [GO:0001931] | actin filament binding [GO:0051015]; identical protein binding [GO:0042802] | 4452.92401621644 | -1.02200909304577 | 0.605737907720918 | 0.958344336046916 |
| Q06330 | Q06330 | SUH_HUMAN | Recombining binding protein suppressor of hairless (CBF-1) (J kappa-recombination signal-binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (Renal carcinoma antigen NY-REN-30) | RBPJ | angiogenesis [GO:0001525]; aortic valve development [GO:0003176]; arterial endothelial cell fate commitment [GO:0060844]; atrioventricular canal development [GO:0036302]; auditory receptor cell fate commitment [GO:0009912]; B cell differentiation [GO:0030183]; blood vessel endothelial cell fate specification [GO:0097101]; blood vessel lumenization [GO:0072554]; blood vessel remodeling [GO:0001974]; cardiac left ventricle morphogenesis [GO:0003214]; cardiac muscle cell myoblast differentiation [GO:0060379]; club cell differentiation [GO:0060486]; defense response to bacterium [GO:0042742]; dorsal aorta morphogenesis [GO:0035912]; endocardium morphogenesis [GO:0003160]; epidermal cell fate specification [GO:0009957]; epithelial cell proliferation [GO:0050673]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; hair follicle maturation [GO:0048820]; heart development [GO:0007507]; humoral immune response [GO:0006959]; inflammatory response to antigenic stimulus [GO:0002437]; keratinocyte differentiation [GO:0030216]; labyrinthine layer blood vessel development [GO:0060716]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of ossification [GO:0030279]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; outflow tract morphogenesis [GO:0003151]; pituitary gland development [GO:0021983]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell proliferation involved in heart morphogenesis [GO:2000138]; positive regulation of ephrin receptor signaling pathway [GO:1901189]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERBB signaling pathway [GO:1901186]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of Notch receptor target [GO:0007221]; pulmonary valve development [GO:0003177]; regulation of cell adhesion involved in heart morphogenesis [GO:0061344]; regulation of generation of precursor metabolites and energy [GO:0043467]; regulation of reproductive process [GO:2000241]; regulation of timing of cell differentiation [GO:0048505]; regulation of transcription by RNA polymerase II [GO:0006357]; sebaceous gland development [GO:0048733]; secondary heart field specification [GO:0003139]; somatic stem cell population maintenance [GO:0035019]; somitogenesis [GO:0001756]; stem cell proliferation [GO:0072089]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222] | chromatin [GO:0000785]; cytoplasm [GO:0005737]; MAML1-RBP-Jkappa- ICN1 complex [GO:0002193]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] | chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565] | 13748.81415418735 | -0.184847152487261 | 0.606130783919351 | 0.958344336046916 |
| P62877 | P62877 | RBX1_HUMAN | E3 ubiquitin-protein ligase RBX1 (EC 2.3.2.27) (EC 2.3.2.32) (E3 ubiquitin-protein transferase RBX1) (Protein ZYP) (RING finger protein 75) (RING-box protein 1) (Rbx1) (Regulator of cullins 1) (ROC1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed (E3 ubiquitin-protein transferase RBX1, N-terminally processed)] | RBX1 | cellular response to amino acid stimulus [GO:0071230]; cellular response to chemical stress [GO:0062197]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; MAPK cascade [GO:0000165]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of response to oxidative stress [GO:1902883]; negative regulation of type I interferon production [GO:0032480]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein autoubiquitination [GO:1902499]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of TORC1 signaling [GO:1904263]; post-translational protein modification [GO:0043687]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; protein neddylation [GO:0045116]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; spermatogenesis [GO:0007283]; T cell activation [GO:0042110]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627] | Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul3-RING ubiquitin ligase complex [GO:0031463]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; Cul5-RING ubiquitin ligase complex [GO:0031466]; Cul7-RING ubiquitin ligase complex [GO:0031467]; cullin-RING ubiquitin ligase complex [GO:0031461]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005] | cullin family protein binding [GO:0097602]; molecular adaptor activity [GO:0060090]; NEDD8 ligase activity [GO:0061663]; NEDD8 transferase activity [GO:0019788]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-ubiquitin ligase activity [GO:0034450]; zinc ion binding [GO:0008270] | 25720.669219188647 | -0.0510810084776807 | 0.60639090544677 | 0.958344336046916 |
| Q8N392 | Q8N392 | RHG18_HUMAN | Rho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18) | ARHGAP18 | regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament polymerization [GO:0030833]; regulation of cell motility [GO:2000145]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264] | cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; ruffle [GO:0001726] | cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096] | 14433.45296014005 | -0.111162291199847 | 0.606729740109435 | 0.95838603497632 |
| Q9HCG8 | Q9HCG8 | CWC22_HUMAN | Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb) | CWC22 | mRNA splicing, via spliceosome [GO:0000398]; regulation of mRNA splicing, via spliceosome [GO:0048024] | catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005] | RNA binding [GO:0003723] | 3159.289717309805 | 0.262024325513386 | 0.608298804701781 | 0.960108179751486 |
| Q9BRT2 | Q9BRT2 | UQCC2_HUMAN | Ubiquinol-cytochrome c reductase complex assembly factor 2 (Breast cancer-associated protein SGA-81M) (Mitochondrial nucleoid factor 1) (Mitochondrial protein M19) | UQCC2 | mitochondrial respiratory chain complex III assembly [GO:0034551]; positive regulation of mitochondrial translation [GO:0070131]; regulation of insulin secretion [GO:0050796]; regulation of oxidative phosphorylation [GO:0002082]; regulation of skeletal muscle cell differentiation [GO:2001014] | mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nuclear body [GO:0016604] | 8998.14129483432 | 0.308102421847462 | 0.60818266203348 | 0.960108179751486 | |
| Q8WVX9 | Q8WVX9 | FACR1_HUMAN | Fatty acyl-CoA reductase 1 (EC 1.2.1.84) (Male sterility domain-containing protein 2) | FAR1 | ether lipid biosynthetic process [GO:0008611]; glycerophospholipid biosynthetic process [GO:0046474]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; wax biosynthetic process [GO:0010025] | peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] | alcohol-forming long-chain fatty acyl-CoA reductase activity [GO:0102965]; alcohol-forming very long-chain fatty acyl-CoA reductase activity [GO:0080019]; oxidoreductase activity [GO:0016491] | 7891.48830757618 | -1.29379583178792 | 0.609101718422869 | 0.960526116499854 |
| P09001 | P09001 | RM03_HUMAN | Large ribosomal subunit protein uL3m (39S ribosomal protein L3, mitochondrial) (L3mt) (MRP-L3) | MRPL3 | mitochondrial translation [GO:0032543]; translation [GO:0006412] | cytosolic large ribosomal subunit [GO:0022625]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 7488.9254914473095 | -0.152078817250309 | 0.609065197282321 | 0.960526116499854 |
| Q86TB9 | Q86TB9 | PATL1_HUMAN | Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) (hPat1b) | PATL1 | deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; P-body assembly [GO:0033962] | cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; P-body [GO:0000932]; PML body [GO:0016605] | poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723] | 8568.06444130306 | -0.140449319506077 | 0.608981815848287 | 0.960526116499854 |
| P50502 | P50502 | F10A1_HUMAN | Hsc70-interacting protein (Hip) (Aging-associated protein 2) (Progesterone receptor-associated p48 protein) (Protein FAM10A1) (Putative tumor suppressor ST13) (Renal carcinoma antigen NY-REN-33) (Suppression of tumorigenicity 13 protein) | ST13 | chaperone cofactor-dependent protein refolding [GO:0051085]; protein folding [GO:0006457]; response to bacterium [GO:0009617] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] | Hsp70 protein binding [GO:0030544]; protein dimerization activity [GO:0046983]; protein-macromolecule adaptor activity [GO:0030674] | 142041.268151186 | 0.0836080327395236 | 0.609658441455937 | 0.96113654126025 |
| O43617 | O43617 | TPPC3_HUMAN | Trafficking protein particle complex subunit 3 (BET3 homolog) | TRAPPC3 | COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022] | cis-Golgi network membrane [GO:0033106]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072] | 15889.25169739245 | 0.21890937318667 | 0.610376319393666 | 0.961931323414901 | |
| P02686 | P02686 | MBP_HUMAN | Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein) | MBP | axon ensheathment [GO:0008366]; central nervous system development [GO:0007417]; chemical synaptic transmission [GO:0007268]; immune response [GO:0006955]; maintenance of blood-brain barrier [GO:0035633]; MAPK cascade [GO:0000165]; membrane organization [GO:0061024]; myelination [GO:0042552]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of metalloendopeptidase activity [GO:1904685]; response to toxic substance [GO:0009636]; sensory perception of sound [GO:0007605]; substantia nigra development [GO:0021762] | cell periphery [GO:0071944]; cell surface [GO:0009986]; compact myelin [GO:0043218]; cytosol [GO:0005829]; internode region of axon [GO:0033269]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; synapse [GO:0045202] | calmodulin binding [GO:0005516]; lipid binding [GO:0008289]; protease binding [GO:0002020]; structural constituent of myelin sheath [GO:0019911] | 11717.737577718799 | -0.241221972404157 | 0.61264122182356 | 0.96449712777224 |
| P20585 | P20585 | MSH3_HUMAN | DNA mismatch repair protein Msh3 (hMSH3) (Divergent upstream protein) (DUP) (Mismatch repair protein 1) (MRP1) | MSH3 | DNA repair [GO:0006281]; maintenance of DNA repeat elements [GO:0043570]; mismatch repair [GO:0006298]; mitotic recombination [GO:0006312]; negative regulation of DNA recombination [GO:0045910]; positive regulation of helicase activity [GO:0051096]; somatic recombination of immunoglobulin gene segments [GO:0016447] | membrane [GO:0016020]; MutSbeta complex [GO:0032302]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; mismatched DNA binding [GO:0030983] | 1404.49085140587 | -0.142487656927678 | 0.613662922769285 | 0.965300977348909 |
| P17612 | P17612 | KAPCA_HUMAN | cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11) | PRKACA | adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular response to cold [GO:0070417]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to glucagon stimulus [GO:0071377]; cellular response to glucose stimulus [GO:0071333]; cellular response to heat [GO:0034605]; cellular response to parathyroid hormone stimulus [GO:0071374]; cytokine-mediated signaling pathway [GO:0019221]; high-density lipoprotein particle assembly [GO:0034380]; mesoderm formation [GO:0001707]; mitochondrial protein catabolic process [GO:0035694]; mRNA processing [GO:0006397]; negative regulation of glycolytic process through fructose-6-phosphate [GO:1904539]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of TORC1 signaling [GO:1904262]; neural tube closure [GO:0001843]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of insulin secretion [GO:0032024]; positive regulation of protein export from nucleus [GO:0046827]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein export from nucleus [GO:0006611]; protein kinase A signaling [GO:0010737]; protein localization to lipid droplet [GO:1990044]; protein phosphorylation [GO:0006468]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell cycle [GO:0051726]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of heart rate [GO:0002027]; regulation of macroautophagy [GO:0016241]; regulation of osteoblast differentiation [GO:0045667]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein binding [GO:0043393]; regulation of protein processing [GO:0070613]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; renal water homeostasis [GO:0003091]; sperm capacitation [GO:0048240] | acrosomal vesicle [GO:0001669]; calcium channel complex [GO:0034704]; cAMP-dependent protein kinase complex [GO:0005952]; centrosome [GO:0005813]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; mitochondrial matrix [GO:0005759]; neuromuscular junction [GO:0031594]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225] | AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein domain specific binding [GO:0019904]; protein kinase A regulatory subunit binding [GO:0034237]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; ubiquitin protein ligase binding [GO:0031625] | 38249.6870526234 | 0.132634508207667 | 0.613578558901279 | 0.965300977348909 |
| P19474 | P19474 | RO52_HUMAN | E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21) | TRIM21 | cell cycle [GO:0007049]; cellular response to chemical stress [GO:0062197]; innate immune response [GO:0045087]; negative regulation of innate immune response [GO:0045824]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein deubiquitination [GO:0090086]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell cycle [GO:0045787]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of protein binding [GO:0032092]; positive regulation of viral entry into host cell [GO:0046598]; proteasomal protein catabolic process [GO:0010498]; protein autoubiquitination [GO:0051865]; protein destabilization [GO:0031648]; protein K27-linked ubiquitination [GO:0044314]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; pyroptosis [GO:0070269]; regulation of protein localization [GO:0032880]; regulation of type I interferon production [GO:0032479]; regulation of viral entry into host cell [GO:0046596]; response to type II interferon [GO:0034341]; stress granule disassembly [GO:0035617]; suppression of viral release by host [GO:0044790] | autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904] | DNA binding [GO:0003677]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] | 8856.116380822794 | 0.136458859519093 | 0.613558705520798 | 0.965300977348909 |
| Q86X10 | Q86X10 | RLGPB_HUMAN | Ral GTPase-activating protein subunit beta (p170) | RALGAPB | activation of GTPase activity [GO:0090630]; regulation of small GTPase mediated signal transduction [GO:0051056] | GTPase activator activity [GO:0005096]; protein heterodimerization activity [GO:0046982] | 3000.86879107471 | -0.329864300171504 | 0.614323815334588 | 0.966072366829246 | |
| Q53HC9 | Q53HC9 | EIPR1_HUMAN | EARP and GARP complex-interacting protein 1 (Endosome-associated recycling protein-interacting protein) (Golgi-associated retrograde protein-interacting protein) (Tumor-suppressing STF cDNA 1 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein) | EIPR1 | endocytic recycling [GO:0032456]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of retrograde transport, endosome to Golgi [GO:1905281]; protein ubiquitination [GO:0016567]; regulation of insulin secretion [GO:0050796] | trans-Golgi network [GO:0005802] | 8064.369471239645 | 0.195236370996659 | 0.614948444248498 | 0.966250106797556 | |
| Q8NBM8 | Q8NBM8 | PCYXL_HUMAN | Prenylcysteine oxidase-like (EC 1.8.3.-) | PCYOX1L | prenylated protein catabolic process [GO:0030327]; prenylcysteine catabolic process [GO:0030328] | extracellular region [GO:0005576]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093] | prenylcysteine oxidase activity [GO:0001735] | 32057.10869384875 | 0.114200366944343 | 0.614621525000463 | 0.966250106797556 |
| Q9BVS4 | Q9BVS4 | RIOK2_HUMAN | Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) | RIOK2 | cell cycle [GO:0007049]; maturation of SSU-rRNA [GO:0030490]; positive regulation of ribosomal small subunit export from nucleus [GO:2000208]; positive regulation of rRNA processing [GO:2000234]; protein autophosphorylation [GO:0046777]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; ribosomal small subunit biogenesis [GO:0042274] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, small subunit precursor [GO:0030688] | ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | 5807.887875930444 | -0.221107698606232 | 0.614828490554923 | 0.966250106797556 |
| Q8N1G2 | Q8N1G2 | CMTR1_HUMAN | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95) | CMTR1 | 7-methylguanosine mRNA capping [GO:0006370]; cap1 mRNA methylation [GO:0097309]; mRNA methylation [GO:0080009] | cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | mRNA (nucleoside-2'-O-)-methyltransferase activity [GO:0004483]; nucleic acid binding [GO:0003676] | 2862.0619977862098 | -0.216095340228959 | 0.61667868248807 | 0.967915034227052 |
| Q13542 | Q13542 | 4EBP2_HUMAN | Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) | EIF4EBP2 | insulin receptor signaling pathway [GO:0008286]; memory [GO:0007613]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of translational initiation [GO:0045947]; regulation of synaptic plasticity [GO:0048167]; social behavior [GO:0035176]; TOR signaling [GO:0031929]; translation [GO:0006412] | cytoplasm [GO:0005737]; intracellular non-membrane-bounded organelle [GO:0043232]; neuronal ribonucleoprotein granule [GO:0071598]; nucleus [GO:0005634]; postsynapse [GO:0098794] | eukaryotic initiation factor 4E binding [GO:0008190]; translation repressor activity [GO:0030371] | 14200.222236433649 | 0.236461173797677 | 0.616691364906399 | 0.967915034227052 |
| P0CAP2 | P0CAP2 | GRL1A_HUMAN | DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) | POLR2M | intracellular signal transduction [GO:0035556]; maintenance of ER location [GO:0051685]; transcription elongation by RNA polymerase II [GO:0006368] | I band [GO:0031674]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; RNA polymerase II, core complex [GO:0005665]; RNA polymerase II, holoenzyme [GO:0016591]; transcription preinitiation complex [GO:0097550] | RNA polymerase II complex binding [GO:0000993]; transcription elongation factor activity [GO:0003711] | 2102.567093858945 | -0.0892562989116532 | 0.616378434429698 | 0.967915034227052 |
| O14936 | O14936 | CSKP_HUMAN | Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog) | CASK | calcium ion import [GO:0070509]; cell adhesion [GO:0007155]; establishment of localization in cell [GO:0051649]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of cellular response to growth factor stimulus [GO:0090288]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of wound healing [GO:0061045]; phosphorylation [GO:0016310]; positive regulation of calcium ion import [GO:0090280]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synaptic vesicle exocytosis [GO:2000300] | actin cytoskeleton [GO:0015629]; basement membrane [GO:0005604]; basolateral plasma membrane [GO:0016323]; cell-cell junction [GO:0005911]; ciliary membrane [GO:0060170]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nuclear lamina [GO:0005652]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; vesicle [GO:0031982] | ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; guanylate kinase activity [GO:0004385]; neurexin family protein binding [GO:0042043]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; signaling receptor binding [GO:0005102] | 10242.509837733865 | 0.108545105694551 | 0.617242869344914 | 0.968244213097532 |
| Q8IYM9 | Q8IYM9 | TRI22_HUMAN | E3 ubiquitin-protein ligase TRIM22 (EC 2.3.2.27) (50 kDa-stimulated trans-acting factor) (RING finger protein 94) (RING-type E3 ubiquitin transferase TRIM22) (Staf-50) (Tripartite motif-containing protein 22) | TRIM22 | defense response to virus [GO:0051607]; immune response [GO:0006955]; innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]; response to virus [GO:0009615] | Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] | 15032.5965350708 | -0.0990641164318857 | 0.617113396113138 | 0.968244213097532 |
| O75882 | O75882 | ATRN_HUMAN | Attractin (DPPT-L) (Mahogany homolog) | ATRN | cerebellum development [GO:0021549]; inflammatory response [GO:0006954]; myelination [GO:0042552]; pigmentation [GO:0043473]; regulation of multicellular organism growth [GO:0040014] | extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] | carbohydrate binding [GO:0030246]; signaling receptor activity [GO:0038023] | 8256.7901472615 | 0.217557237063031 | 0.61771583883619 | 0.96871794709268 |
| O43493 | O43493 | TGON2_HUMAN | Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2) | TGOLN2 | clathrin-coated endocytic vesicle membrane [GO:0030669]; endoplasmic reticulum lumen [GO:0005788]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; trans-Golgi network transport vesicle [GO:0030140]; transport vesicle [GO:0030133] | 48392.80695946495 | 0.199623659275185 | 0.619134056252728 | 0.970673370981726 | ||
| P45954 | P45954 | ACDSB_HUMAN | Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (SBCAD) (EC 1.3.8.5) (2-methyl branched chain acyl-CoA dehydrogenase) (2-MEBCAD) (2-methylbutyryl-coenzyme A dehydrogenase) (2-methylbutyryl-CoA dehydrogenase) | ACADSB | fatty acid metabolic process [GO:0006631]; isoleucine catabolic process [GO:0006550] | mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] | 2-methylbutanoyl-CoA dehydrogenase activity [GO:0003853]; 2-methylpropanoyl-CoA dehydrogenase activity [GO:0102035]; acyl-CoA dehydrogenase activity [GO:0003995]; butyryl-CoA dehydrogenase activity [GO:0004085]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; short-chain fatty acyl-CoA dehydrogenase activity [GO:0016937] | 9171.56820272576 | 0.0907682341024184 | 0.619526058375559 | 0.970981310521632 |
| P27986 | P27986 | P85A_HUMAN | Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) | PIK3R1 | B cell differentiation [GO:0030183]; cellular response to insulin stimulus [GO:0032869]; cellular response to UV [GO:0034644]; cytokine-mediated signaling pathway [GO:0019221]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; growth hormone receptor signaling pathway [GO:0060396]; immune response [GO:0006955]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; interleukin-18-mediated signaling pathway [GO:0035655]; intracellular glucose homeostasis [GO:0001678]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; myeloid leukocyte migration [GO:0097529]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of stress fiber assembly [GO:0051497]; osteoclast differentiation [GO:0030316]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of glucose import [GO:0046326]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of RNA splicing [GO:0033120]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; protein import into nucleus [GO:0006606]; protein stabilization [GO:0050821]; regulation of toll-like receptor 4 signaling pathway [GO:0034143]; response to endoplasmic reticulum stress [GO:0034976]; substrate adhesion-dependent cell spreading [GO:0034446]; T cell differentiation [GO:0030217]; transcription by RNA polymerase II [GO:0006366] | cell-cell junction [GO:0005911]; cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum membrane [GO:1990578]; perinuclear region of cytoplasm [GO:0048471]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; plasma membrane [GO:0005886] | 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; enzyme-substrate adaptor activity [GO:0140767]; ErbB-3 class receptor binding [GO:0043125]; insulin binding [GO:0043559]; insulin receptor binding [GO:0005158]; insulin receptor substrate binding [GO:0043560]; insulin-like growth factor receptor binding [GO:0005159]; kinase activator activity [GO:0019209]; neurotrophin TRKA receptor binding [GO:0005168]; phosphatidylinositol 3-kinase activator activity [GO:0141038]; phosphatidylinositol 3-kinase binding [GO:0043548]; phosphatidylinositol 3-kinase regulator activity [GO:0035014]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; phosphatidylinositol kinase activity [GO:0052742]; phosphotyrosine residue binding [GO:0001784]; protein heterodimerization activity [GO:0046982]; protein phosphatase binding [GO:0019903]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] | 11023.44707323965 | -0.337119634382583 | 0.619673211938973 | 0.970981310521632 |
| Q96JC1 | Q96JC1 | VPS39_HUMAN | Vam6/Vps39-like protein (TRAP1-like protein) (hVam6p) | VPS39 | autophagosome-lysosome fusion [GO:0061909]; autophagy [GO:0006914]; endocytic recycling [GO:0032456]; endosomal vesicle fusion [GO:0034058]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; late endosome to lysosome transport [GO:1902774]; regulation of SNARE complex assembly [GO:0035542] | AP-3 adaptor complex [GO:0030123]; cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal HOPS complex [GO:1902501]; lysosomal membrane [GO:0005765]; membrane [GO:0016020] | 4414.674647388985 | -0.252787403022842 | 0.619893775646982 | 0.971058372357148 | |
| Q9BYV8 | Q9BYV8 | CEP41_HUMAN | Centrosomal protein of 41 kDa (Cep41) (Testis-specific gene A14 protein) | CEP41 | cilium assembly [GO:0060271]; protein polyglutamylation [GO:0018095]; protein transport [GO:0015031] | centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; membrane [GO:0016020] | 9999.84085772726 | 0.123429938869376 | 0.620686899996289 | 0.971803895968563 | |
| P60510 | P60510 | PP4C_HUMAN | Serine/threonine-protein phosphatase 4 catalytic subunit (PP4C) (Pp4) (EC 3.1.3.16) (Protein phosphatase X) (PP-X) | PPP4C | double-strand break repair via homologous recombination [GO:0000724]; regulation of double-strand break repair [GO:2000779]; regulation of double-strand break repair via homologous recombination [GO:0010569] | centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein phosphatase 4 complex [GO:0030289] | metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein serine/threonine phosphatase activity [GO:0004722] | 29003.789527897003 | 0.135203310055414 | 0.620712724940033 | 0.971803895968563 |
| Q96D46 | Q96D46 | NMD3_HUMAN | 60S ribosomal export protein NMD3 (hNMD3) | NMD3 | positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to nucleolus [GO:1904751]; positive regulation of RNA biosynthetic process [GO:1902680]; protein transport [GO:0015031]; ribosomal large subunit export from nucleus [GO:0000055] | cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | protein-macromolecule adaptor activity [GO:0030674]; ribosomal large subunit binding [GO:0043023]; RNA binding [GO:0003723] | 11561.5745204398 | 0.0884378000743404 | 0.620933966517814 | 0.971881727704401 |
| Q66K74 | Q66K74 | MAP1S_HUMAN | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | MAP1S | apoptotic process [GO:0006915]; autophagy [GO:0006914]; axonogenesis [GO:0007409]; brain development [GO:0007420]; dendrite development [GO:0016358]; metaphase chromosome alignment [GO:0051310]; microtubule anchoring at centrosome [GO:0034454]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; mitochondrion transport along microtubule [GO:0047497]; mitotic spindle organization [GO:0007052]; nervous system development [GO:0007399]; neuron projection morphogenesis [GO:0048812]; regulation of microtubule depolymerization [GO:0031114] | cell junction [GO:0030054]; cell projection [GO:0042995]; centrosome [GO:0005813]; cytosol [GO:0005829]; dendrite [GO:0030425]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule organizing center [GO:0005815]; mitotic spindle microtubule [GO:1990498]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; spindle [GO:0005819]; synapse [GO:0045202] | actin binding [GO:0003779]; actin filament binding [GO:0051015]; beta-tubulin binding [GO:0048487]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; tubulin binding [GO:0015631] | 22715.32907632285 | -0.145365210831504 | 0.621925843163467 | 0.972628161016893 |
| O15042 | O15042 | SR140_HUMAN | U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) | U2SURP | RNA processing [GO:0006396] | nucleoplasm [GO:0005654]; nucleus [GO:0005634] | RNA binding [GO:0003723] | 15255.23221855855 | -0.0666431196773564 | 0.62188613021856 | 0.972628161016893 |
| P56937 | P56937 | DHB7_HUMAN | 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (17-beta-hydroxysteroid dehydrogenase 7) (17-beta-HSD 7) (3-keto-steroid reductase) (EC 1.1.1.270) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Estradiol 17-beta-dehydrogenase 7) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 37C member 1) | HSD17B7 | androgen metabolic process [GO:0008209]; cholesterol biosynthetic process [GO:0006695]; estrogen biosynthetic process [GO:0006703] | endoplasmic reticulum membrane [GO:0005789] | 3-keto sterol reductase activity [GO:0000253]; 5alpha-androstane-3beta,17beta-diol dehydrogenase activity [GO:0047024]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303] | 9744.50213510856 | 0.240813960680062 | 0.622904238372536 | 0.973889463195029 |
| Q8IYB7 | Q8IYB7 | DI3L2_HUMAN | DIS3-like exonuclease 2 (hDIS3L2) (EC 3.1.13.-) | DIS3L2 | cell division [GO:0051301]; miRNA catabolic process [GO:0010587]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid separation [GO:0051306]; mRNA catabolic process [GO:0006402]; negative regulation of cell population proliferation [GO:0008285]; nuclear-transcribed mRNA catabolic process, exonucleolytic [GO:0000291]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyuridylation-dependent mRNA catabolic process [GO:1990074]; stem cell population maintenance [GO:0019827] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; P-body [GO:0000932] | 3'-5'-RNA exonuclease activity [GO:0000175]; magnesium ion binding [GO:0000287]; poly(U) RNA binding [GO:0008266]; RNA nuclease activity [GO:0004540] | 5701.686616770296 | -0.437927320528255 | 0.623256750389 | 0.973903129537804 |
| Q00577 | Q00577 | PURA_HUMAN | Transcriptional activator protein Pur-alpha (Purine-rich single-stranded DNA-binding protein alpha) | PURA | dendritic transport of messenger ribonucleoprotein complex [GO:0098963]; DNA replication initiation [GO:0006270]; DNA unwinding involved in DNA replication [GO:0006268]; epithelial cell proliferation [GO:0050673]; lymphocyte proliferation [GO:0046651]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of cell population proliferation [GO:0008284]; regulation of transcription by RNA polymerase II [GO:0006357] | chromosome, telomeric region [GO:0000781]; dendrite cytoplasm [GO:0032839]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; postsynapse [GO:0098794] | DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; double-stranded telomeric DNA binding [GO:0003691]; mRNA regulatory element binding translation repressor activity [GO:0000900]; purine-rich negative regulatory element binding [GO:0032422]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; single-stranded DNA binding [GO:0003697]; SMAD binding [GO:0046332]; transcription regulator inhibitor activity [GO:0140416] | 26588.685896006347 | 0.101190537320465 | 0.623621329308865 | 0.974204149948726 |
| Q9H8T0 | Q9H8T0 | AKTIP_HUMAN | AKT-interacting protein (Ft1) (Fused toes protein homolog) | AKTIP | apoptotic process [GO:0006915]; early endosome to late endosome transport [GO:0045022]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; lysosome organization [GO:0007040]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein neddylation [GO:0045116]; protein transport [GO:0015031] | FHF complex [GO:0070695]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | NEDD8 transferase activity [GO:0019788] | 11170.189914554649 | 0.110712780547284 | 0.6238976236649 | 0.974367126704885 |
| Q9H3L0 | Q9H3L0 | MMAD_HUMAN | Cobalamin trafficking protein CblD (CblD) (Methylmalonic aciduria and homocystinuria type D protein, mitochondrial) | MMADHC | cobalamin metabolic process [GO:0009235] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739] | 10713.1581961142 | 0.23911176516666 | 0.624385596974698 | 0.974501989868956 | |
| Q9Y2A7 | Q9Y2A7 | NCKP1_HUMAN | Nck-associated protein 1 (NAP 1) (Membrane-associated protein HEM-2) (p125Nap1) | NCKAP1 | apoptotic process [GO:0006915]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell projection assembly [GO:0030031]; central nervous system development [GO:0007417]; cortical actin cytoskeleton organization [GO:0030866]; neuron projection morphogenesis [GO:0048812]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of lamellipodium assembly [GO:0010592]; Rac protein signal transduction [GO:0016601] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filamentous actin [GO:0031941]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; ruffle [GO:0001726]; SCAR complex [GO:0031209] | 14816.00834668315 | -0.166848339173444 | 0.624354035091254 | 0.974501989868956 | |
| Q9NQZ2 | Q9NQZ2 | SAS10_HUMAN | Something about silencing protein 10 (Charged amino acid-rich leucine zipper 1) (CRL1) (Disrupter of silencing SAS10) (UTP3 homolog) | UTP3 | brain development [GO:0007420]; chromatin organization [GO:0006325]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274] | nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040] | RNA binding [GO:0003723] | 11931.741570961101 | 0.0930767327830536 | 0.624499951502679 | 0.974501989868956 |
| O60573 | O60573 | IF4E2_HUMAN | Eukaryotic translation initiation factor 4E type 2 (eIF-4E type 2) (eIF4E type 2) (Eukaryotic translation initiation factor 4E homologous protein) (Eukaryotic translation initiation factor 4E-like 3) (eIF4E-like protein 4E-LP) (mRNA cap-binding protein 4EHP) (h4EHP) (mRNA cap-binding protein type 3) | EIF4E2 | miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; rescue of stalled ribosome [GO:0072344]; translational initiation [GO:0006413] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; P-body [GO:0000932] | mRNA cap binding [GO:0098808]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; ubiquitin protein ligase binding [GO:0031625] | 10334.821995291164 | 0.281806981274905 | 0.625309956458649 | 0.974960432937453 |
| P23258 | P23258 | TBG1_HUMAN | Tubulin gamma-1 chain (Gamma-1-tubulin) (Gamma-tubulin complex component 1) (GCP-1) | TUBG1 | cytoplasmic microtubule organization [GO:0031122]; meiotic spindle organization [GO:0000212]; microtubule cytoskeleton organization [GO:0000226]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle organization [GO:0007052] | apical part of cell [GO:0045177]; cell leading edge [GO:0031252]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; gamma-tubulin complex [GO:0000930]; microtubule [GO:0005874]; mitotic spindle microtubule [GO:1990498]; neuron projection [GO:0043005]; non-motile cilium [GO:0097730]; nucleus [GO:0005634]; pericentriolar material [GO:0000242]; polar microtubule [GO:0005827]; recycling endosome [GO:0055037]; spindle [GO:0005819] | GTP binding [GO:0005525]; identical protein binding [GO:0042802]; structural constituent of cytoskeleton [GO:0005200] | 11918.5870702266 | 0.0618048706291614 | 0.625203419785999 | 0.974960432937453 |
| Q8TD43 | Q8TD43 | TRPM4_HUMAN | Transient receptor potential cation channel subfamily M member 4 (hTRPM4) (Calcium-activated non-selective cation channel 1) (Long transient receptor potential channel 4) (LTrpC-4) (LTrpC4) (Melastatin-4) | TRPM4 | adaptive immune response [GO:0002250]; calcium ion transmembrane transport [GO:0070588]; calcium-mediated signaling [GO:0019722]; cellular response to ATP [GO:0071318]; dendritic cell chemotaxis [GO:0002407]; inorganic cation transmembrane transport [GO:0098662]; membrane depolarization during AV node cell action potential [GO:0086045]; membrane depolarization during bundle of His cell action potential [GO:0086048]; membrane depolarization during Purkinje myocyte cell action potential [GO:0086047]; negative regulation of bone mineralization [GO:0030502]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of atrial cardiac muscle cell action potential [GO:1903949]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of heart rate [GO:0010460]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization [GO:1904199]; positive regulation of vasoconstriction [GO:0045907]; protein homotetramerization [GO:0051289]; protein sumoylation [GO:0016925]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of T cell cytokine production [GO:0002724]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; sodium ion import across plasma membrane [GO:0098719] | cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sodium channel complex [GO:0034706] | ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; calcium-activated cation channel activity [GO:0005227]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; ligand-gated calcium channel activity [GO:0099604]; sodium channel activity [GO:0005272] | 7729.804455173595 | -0.158471238223144 | 0.625813707750229 | 0.975209149645984 |
| Q9H2H8 | Q9H2H8 | PPIL3_HUMAN | Peptidyl-prolyl cis-trans isomerase-like 3 (PPIase) (EC 5.2.1.8) (Cyclophilin J) (CyPJ) (Cyclophilin-like protein PPIL3) (Rotamase PPIL3) | PPIL3 | mRNA splicing, via spliceosome [GO:0000398]; protein folding [GO:0006457] | catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654] | peptidyl-prolyl cis-trans isomerase activity [GO:0003755] | 14339.89281593345 | 0.190538290724292 | 0.626132239516329 | 0.975437247484059 |
| O43427 | O43427 | FIBP_HUMAN | Acidic fibroblast growth factor intracellular-binding protein (aFGF intracellular-binding protein) (FGF-1 intracellular-binding protein) | FIBP | fibroblast growth factor receptor signaling pathway [GO:0008543]; platelet aggregation [GO:0070527] | endomembrane system [GO:0012505]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleus [GO:0005634] | fibroblast growth factor binding [GO:0017134] | 4168.622356992425 | -0.149883372985288 | 0.626510772740319 | 0.975490529911142 |
| P20700 | P20700 | LMNB1_HUMAN | Lamin-B1 | LMNB1 | heterochromatin formation [GO:0031507]; nuclear envelope organization [GO:0006998]; nuclear migration [GO:0007097]; nuclear pore localization [GO:0051664]; protein localization to nuclear envelope [GO:0090435] | lamin filament [GO:0005638]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear lamina [GO:0005652]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | phospholipase binding [GO:0043274]; sequence-specific double-stranded DNA binding [GO:1990837]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of nuclear lamina [GO:0160123] | 31283.6796924421 | 0.0913017373025041 | 0.626443200929292 | 0.975490529911142 |
| P15735 | P15735 | PHKG2_HUMAN | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHK-gamma-LT) (PHK-gamma-T) (EC 2.7.11.19) (PSK-C3) (Phosphorylase kinase subunit gamma-2) | PHKG2 | generation of precursor metabolites and energy [GO:0006091]; glycogen biosynthetic process [GO:0005978]; glycogen catabolic process [GO:0005980]; glycogen metabolic process [GO:0005977]; positive regulation of glycogen catabolic process [GO:0045819]; protein phosphorylation [GO:0006468] | cytosol [GO:0005829]; phosphorylase kinase complex [GO:0005964] | ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; phosphorylase kinase activity [GO:0004689]; protein serine/threonine kinase activity [GO:0004674]; tau-protein kinase activity [GO:0050321] | 11164.3332094914 | -0.198602564403352 | 0.627428056321417 | 0.976511278554857 |
| Q96S59 | Q96S59 | RANB9_HUMAN | Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7) | RANBP9 | cytoskeleton organization [GO:0007010]; microtubule nucleation [GO:0007020]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; positive regulation of amyloid precursor protein catabolic process [GO:1902993]; protein-containing complex assembly [GO:0065003] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule associated complex [GO:0005875]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151] | enzyme binding [GO:0019899]; small GTPase binding [GO:0031267] | 9740.491614007566 | -0.201734377941131 | 0.627511042219949 | 0.976511278554857 |
| Q96EK7 | Q96EK7 | F120B_HUMAN | Constitutive coactivator of peroxisome proliferator-activated receptor gamma (Constitutive coactivator of PPAR-gamma) (Constitutive coactivator of PPARG) (PPARG constitutive coactivator 1) (PGCC1) (Protein FAM120B) | FAM120B | fat cell differentiation [GO:0045444]; peroxisome proliferator activated receptor signaling pathway [GO:0035357] | nucleus [GO:0005634] | 7464.5763635546355 | -0.147377284767369 | 0.627684997491612 | 0.976513054262816 | |
| P04216 | P04216 | THY1_HUMAN | Thy-1 membrane glycoprotein (CDw90) (Thy-1 antigen) (CD antigen CD90) | THY1 | angiogenesis [GO:0001525]; cell-cell adhesion [GO:0098609]; cell-cell signaling [GO:0007267]; cytoskeleton organization [GO:0007010]; focal adhesion assembly [GO:0048041]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell migration [GO:0030336]; negative regulation of neuron projection regeneration [GO:0070571]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of T cell receptor signaling pathway [GO:0050860]; positive regulation of cellular extravasation [GO:0002693]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of GTPase activity [GO:0043547]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of T cell activation [GO:0050870]; receptor clustering [GO:0043113]; regulation of cell-matrix adhesion [GO:0001952]; regulation of Rho-dependent protein serine/threonine kinase activity [GO:2000298]; retinal cone cell development [GO:0046549]; T cell receptor signaling pathway [GO:0050852] | apical plasma membrane [GO:0016324]; axolemma [GO:0030673]; cell surface [GO:0009986]; dendrite [GO:0030425]; dendrite membrane [GO:0032590]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; membrane raft [GO:0045121]; myelin sheath [GO:0043209]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886] | GPI anchor binding [GO:0034235]; GTPase activator activity [GO:0005096]; integrin binding [GO:0005178] | 200434.45647053252 | 0.187322373016 | 0.62801710772936 | 0.976513054262816 |
| O94967 | O94967 | WDR47_HUMAN | WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) | WDR47 | adult locomotory behavior [GO:0008344]; anterior commissure morphogenesis [GO:0021960]; autophagy [GO:0006914]; cerebral cortex radial glia-guided migration [GO:0021801]; corpus callosum development [GO:0022038]; detection of hot stimulus involved in thermoception [GO:0120168]; microtubule cytoskeleton organization [GO:0000226]; motor behavior [GO:0061744]; negative regulation of microtubule depolymerization [GO:0007026]; neural precursor cell proliferation [GO:0061351]; neuronal stem cell population maintenance [GO:0097150] | cytoplasm [GO:0005737]; dendrite [GO:0030425]; growth cone [GO:0030426]; microtubule [GO:0005874]; neuronal cell body [GO:0043025] | 4542.52041858488 | -0.148662497442627 | 0.628029221626139 | 0.976513054262816 | |
| Q8NBU5 | Q8NBU5 | ATAD1_HUMAN | Outer mitochondrial transmembrane helix translocase (EC 7.4.2.-) (ATPase family AAA domain-containing protein 1) (hATAD1) (Thorase) | ATAD1 | extraction of mislocalized protein from mitochondrial outer membrane [GO:0140570]; learning [GO:0007612]; memory [GO:0007613]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; positive regulation of receptor internalization [GO:0002092]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149] | cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; peroxisomal membrane [GO:0005778]; postsynaptic membrane [GO:0045211] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; membrane protein dislocase activity [GO:0140567] | 7862.794706211505 | 0.1266300891625 | 0.628875681269047 | 0.977080802237177 |
| Q14814 | Q14814 | MEF2D_HUMAN | Myocyte-specific enhancer factor 2D | MEF2D | adult heart development [GO:0007512]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; chondrocyte differentiation [GO:0002062]; endochondral ossification [GO:0001958]; muscle organ development [GO:0007517]; nervous system development [GO:0007399]; osteoblast differentiation [GO:0001649]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; skeletal muscle cell differentiation [GO:0035914] | chromatin [GO:0000785]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837] | 6621.480192696656 | -0.0736047252674809 | 0.628911698863216 | 0.977080802237177 |
| Q8N668 | Q8N668 | COMD1_HUMAN | COMM domain-containing protein 1 (Protein Murr1) | COMMD1 | copper ion homeostasis [GO:0055070]; Golgi to plasma membrane transport [GO:0006893]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of sodium ion transmembrane transport [GO:1902306]; nucleotide-excision repair [GO:0006289]; plasma membrane to endosome transport [GO:0048227]; positive regulation of protein ubiquitination [GO:0031398]; protein transport [GO:0015031]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434] | Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; recycling endosome [GO:0055037] | copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein homodimerization activity [GO:0042803]; sodium channel inhibitor activity [GO:0019871] | 15486.3419909763 | -0.232145978621003 | 0.629741196336033 | 0.978101320844288 |
| Q9BX40 | Q9BX40 | LS14B_HUMAN | Protein LSM14 homolog B (RNA-associated protein 55B) (hRAP55B) | LSM14B | regulation of translation [GO:0006417] | ribonucleoprotein complex [GO:1990904] | mRNA binding [GO:0003729]; RNA binding [GO:0003723] | 9245.203033062164 | 0.25720560998142 | 0.630051464762196 | 0.97831504503771 |
| Q8IZQ5 | Q8IZQ5 | SELH_HUMAN | Selenoprotein H (SelH) | SELENOH | Golgi apparatus [GO:0005794] | RNA binding [GO:0003723] | 20572.00449452755 | 0.185624585125347 | 0.630979080924096 | 0.979218699675686 | |
| Q9UBU9 | Q9UBU9 | NXF1_HUMAN | Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP) | NXF1 | mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]; protein transport [GO:0015031] | cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nuclear inclusion body [GO:0042405]; nuclear pore [GO:0005643]; nuclear RNA export factor complex [GO:0042272]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | mRNA binding [GO:0003729]; RNA binding [GO:0003723] | 9190.094718839006 | -0.278091010909126 | 0.631721145690144 | 0.980101865137008 |
| Q9NUJ1 | Q9NUJ1 | ABHDA_HUMAN | Palmitoyl-protein thioesterase ABHD10, mitochondrial (EC 3.1.2.22) (Acyl-protein thioesterase ABHD10) (Alpha/beta hydrolase domain-containing protein 10) (Abhydrolase domain-containing protein 10) (Mycophenolic acid acyl-glucuronide esterase, mitochondrial) (EC 3.1.1.93) | ABHD10 | cellular glucuronidation [GO:0052695]; glucuronoside catabolic process [GO:0019391]; protein depalmitoylation [GO:0002084] | cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] | hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; mycophenolic acid acyl-glucuronide esterase activity [GO:0102390]; palmitoyl-(protein) hydrolase activity [GO:0008474] | 14180.62089763595 | 0.137431993299839 | 0.632477953466656 | 0.980616510205995 |
| Q07092 | Q07092 | COGA1_HUMAN | Collagen alpha-1(XVI) chain | COL16A1 | cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cellular response to amino acid stimulus [GO:0071230]; extracellular matrix organization [GO:0030198]; female pregnancy [GO:0007565]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; positive regulation of focal adhesion assembly [GO:0051894] | collagen type IX trimer [GO:0005594]; collagen type XVI trimer [GO:0005597]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615] | extracellular matrix structural constituent conferring tensile strength [GO:0030020]; integrin binding [GO:0005178] | 21607.586942911097 | -0.293467747683921 | 0.633363292661577 | 0.980616510205995 |
| P13929 | P13929 | ENOB_HUMAN | Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase) | ENO3 | canonical glycolysis [GO:0061621]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; phosphopyruvate hydratase complex [GO:0000015]; plasma membrane [GO:0005886] | magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634] | 80906.97645214986 | -0.246823149379063 | 0.633416735574674 | 0.980616510205995 |
| Q8N6R0 | Q8N6R0 | EFNMT_HUMAN | eEF1A lysine and N-terminal methyltransferase (eEF1A-KNMT) (Methyltransferase-like protein 13) [Includes: eEF1A lysine methyltransferase (EC 2.1.1.-); eEF1A N-terminal methyltransferase (EC 2.1.1.-)] | METTL13 | methylation [GO:0032259]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of transcription by RNA polymerase II [GO:0000122] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634] | protein-lysine N-methyltransferase activity [GO:0016279] | 10541.121370907698 | -0.305841179774122 | 0.633325173149888 | 0.980616510205995 |
| Q96E39 | Q96E39 | RMXL1_HUMAN | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RBMXL1 | mRNA processing [GO:0006397]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; RNA splicing [GO:0008380] | spliceosomal complex [GO:0005681] | RNA binding [GO:0003723] | 15434.6289393519 | 0.261452396035226 | 0.633357156869116 | 0.980616510205995 |
| O60499 | O60499 | STX10_HUMAN | Syntaxin-10 (Syn10) | STX10 | Golgi vesicle transport [GO:0048193]; intracellular protein transport [GO:0006886]; regulation of protein localization [GO:0032880]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] | cytosol [GO:0005829]; endomembrane system [GO:0012505]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; SNARE complex [GO:0031201]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; vesicle [GO:0031982] | SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905] | 7229.19203679129 | -0.117806410684057 | 0.633610491327947 | 0.980616510205995 |
| O14817 | O14817 | TSN4_HUMAN | Tetraspanin-4 (Tspan-4) (Novel antigen 2) (NAG-2) (Transmembrane 4 superfamily member 7) | TSPAN4 | protein-containing complex assembly [GO:0065003] | focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; vesicle [GO:0031982] | antigen binding [GO:0003823]; integrin binding [GO:0005178] | 23992.46800089375 | -0.300938635355458 | 0.633957465220034 | 0.98088558108594 |
| A5YKK6 | A5YKK6 | CNOT1_HUMAN | CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1) | CNOT1 | miRNA-mediated post-transcriptional gene silencing [GO:0035195]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; regulation of stem cell population maintenance [GO:2000036]; trophectodermal cell differentiation [GO:0001829] | CCR4-NOT complex [GO:0030014]; CCR4-NOT core complex [GO:0030015]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932]; peroxisomal membrane [GO:0005778] | armadillo repeat domain binding [GO:0070016]; molecular adaptor activity [GO:0060090]; nuclear estrogen receptor binding [GO:0030331]; nuclear retinoic acid receptor binding [GO:0042974]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723] | 6433.806963414565 | -0.237497039698941 | 0.634964056394334 | 0.981371070248307 |
| Q8TDY2 | Q8TDY2 | RBCC1_HUMAN | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | RB1CC1 | autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; cell cycle [GO:0007049]; extrinsic apoptotic signaling pathway [GO:0097191]; glycophagy [GO:0061723]; heart development [GO:0007507]; liver development [GO:0001889]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagy [GO:0010508]; positive regulation of cell size [GO:0045793]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein phosphorylation [GO:0001934]; regulation of protein lipidation [GO:1903059]; reticulophagy [GO:0061709]; ribophagy [GO:0034517] | Atg1/ULK1 kinase complex [GO:1990316]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; lysosome [GO:0005764]; nuclear membrane [GO:0031965]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045] | molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; protein-membrane adaptor activity [GO:0043495] | 4201.6729252288205 | -0.350983238345832 | 0.634958359326357 | 0.981371070248307 |
| Q9UHD9 | Q9UHD9 | UBQL2_HUMAN | Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2) | UBQLN2 | autophagosome assembly [GO:0000045]; ERAD pathway [GO:0036503]; negative regulation of clathrin-dependent endocytosis [GO:1900186]; negative regulation of G protein-coupled receptor internalization [GO:1904021]; positive regulation of ERAD pathway [GO:1904294]; regulation of autophagosome assembly [GO:2000785]; regulation of macroautophagy [GO:0016241]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; ubiquitin-dependent protein catabolic process [GO:0006511] | autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | identical protein binding [GO:0042802]; molecular condensate scaffold activity [GO:0140693]; polyubiquitin modification-dependent protein binding [GO:0031593] | 36367.70614350425 | 0.143993888480839 | 0.634814729112215 | 0.981371070248307 |
| Q9NQE9 | Q9NQE9 | HINT3_HUMAN | Adenosine 5'-monophosphoramidase HINT3 (EC 3.9.1.-) (Histidine triad nucleotide-binding protein 3) (HINT-3) | HINT3 | cytoplasm [GO:0005737]; nucleus [GO:0005634] | adenosine 5'-monophosphoramidase activity [GO:0043530]; identical protein binding [GO:0042802]; nucleotide binding [GO:0000166] | 12736.64423601255 | 0.128410789579756 | 0.635138805862347 | 0.981373458962655 | |
| P62736 | P62736 | ACTA_HUMAN | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | ACTA2 | cellular response to transforming growth factor beta stimulus [GO:0071560]; glomerular mesangial cell development [GO:0072144]; juxtaglomerular apparatus development [GO:0072051]; mesenchyme migration [GO:0090131]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of hepatic stellate cell activation [GO:2000491]; positive regulation of hepatic stellate cell contraction [GO:0061874]; positive regulation of hepatic stellate cell migration [GO:0061870]; regulation of blood pressure [GO:0008217]; response to virus [GO:0009615]; vascular associated smooth muscle contraction [GO:0014829] | basement membrane [GO:0005604]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; motile cilium [GO:0031514]; protein-containing complex [GO:0032991]; smooth muscle contractile fiber [GO:0030485]; stress fiber [GO:0001725] | ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; protein kinase binding [GO:0019901] | 86763.11181499591 | -0.131156779761455 | 0.635943652713235 | 0.981850139619487 |
| Q5T7V8 | Q5T7V8 | GORAB_HUMAN | RAB6-interacting golgin (N-terminal kinase-like-binding protein 1) (NTKL-BP1) (NTKL-binding protein 1) (hNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-BP1) (SCYL1-binding protein 1) | GORAB | hair follicle morphogenesis [GO:0031069]; non-motile cilium assembly [GO:1905515]; positive regulation of smoothened signaling pathway [GO:0045880] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] | 10171.4255898355 | 0.0683529166079721 | 0.635967174797656 | 0.981850139619487 | |
| Q8N5N7 | Q8N5N7 | RM50_HUMAN | Large ribosomal subunit protein mL50 (39S ribosomal protein L50, mitochondrial) (L50mt) (MRP-L50) | MRPL50 | mitochondrial translation [GO:0032543] | cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] | 13903.63850775955 | 0.132458701588797 | 0.635892026633366 | 0.981850139619487 | |
| Q7Z794 | Q7Z794 | K2C1B_HUMAN | Keratin, type II cytoskeletal 1b (Cytokeratin-1B) (CK-1B) (Keratin-77) (K77) (Type-II keratin Kb39) | KRT77 | intermediate filament organization [GO:0045109]; keratinization [GO:0031424] | cornified envelope [GO:0001533]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; keratin filament [GO:0045095] | structural constituent of skin epidermis [GO:0030280] | 5132.397021321765 | -1.19768200388758 | 0.636327175662125 | 0.981973504953805 |
| P19387 | P19387 | RPB3_HUMAN | DNA-directed RNA polymerase II subunit RPB3 (RNA polymerase II subunit 3) (RNA polymerase II subunit B3) (DNA-directed RNA polymerase II 33 kDa polypeptide) (RPB33) (DNA-directed RNA polymerase II subunit C) (RPB31) | POLR2C | transcription by RNA polymerase II [GO:0006366] | cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665] | DNA binding [GO:0003677]; protein dimerization activity [GO:0046983]; RNA polymerase II activity [GO:0001055] | 10857.39822922615 | 0.077383852306457 | 0.637569918927289 | 0.983520599140217 |
| P30260 | P30260 | CDC27_HUMAN | Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) | CDC27 | anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; protein K11-linked ubiquitination [GO:0070979]; protein ubiquitination [GO:0016567]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346] | anaphase-promoting complex [GO:0005680]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819] | protein phosphatase binding [GO:0019903] | 5694.188416342835 | -0.975294301706687 | 0.638319317178668 | 0.983941287072308 |
| P56199 | P56199 | ITA1_HUMAN | Integrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a) | ITGA1 | cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cellular extravasation [GO:0045123]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; neuron projection morphogenesis [GO:0048812]; neutrophil chemotaxis [GO:0030593]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; vasodilation [GO:0042311] | acrosomal vesicle [GO:0001669]; basal part of cell [GO:0045178]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; integrin alpha1-beta1 complex [GO:0034665]; integrin complex [GO:0008305]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886] | collagen binding [GO:0005518]; collagen binding involved in cell-matrix adhesion [GO:0098639]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; protein phosphatase binding [GO:0019903] | 9315.293151959024 | -0.200747989701304 | 0.638335931270901 | 0.983941287072308 |
| Q99538 | Q99538 | LGMN_HUMAN | Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (AEP) (Protease, cysteine 1) | LGMN | activation of cysteine-type endopeptidase activity [GO:0097202]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; associative learning [GO:0008306]; cellular response to amyloid-beta [GO:1904646]; cellular response to calcium ion [GO:0071277]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; dendritic spine organization [GO:0097061]; memory [GO:0007613]; negative regulation of ERBB signaling pathway [GO:1901185]; negative regulation of gene expression [GO:0010629]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of monocyte chemotaxis [GO:0090026]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; receptor catabolic process [GO:0032801]; renal system process [GO:0003014]; response to acidic pH [GO:0010447]; self proteolysis [GO:0097264]; vacuolar protein processing [GO:0006624]; vitamin D metabolic process [GO:0042359] | apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; endolysosome lumen [GO:0036021]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; late endosome [GO:0005770]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471] | cysteine-type endopeptidase activity [GO:0004197]; endopeptidase activator activity [GO:0061133]; peptidase activity [GO:0008233]; tau protein binding [GO:0048156] | 61794.702170298 | -0.165913206979227 | 0.638363602414014 | 0.983941287072308 |
| Q99729 | Q99729 | ROAA_HUMAN | Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (APOBEC1-binding protein 1) (ABBP-1) | HNRNPAB | epithelial to mesenchymal transition [GO:0001837]; mRNA modification [GO:0016556]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; positive regulation of DNA demethylation [GO:1901537]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of gene expression [GO:0010468] | cytoplasm [GO:0005737]; mRNA editing complex [GO:0045293]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; RNA polymerase II transcription regulator complex [GO:0090575] | mRNA binding [GO:0003729]; RNA binding [GO:0003723] | 29437.7785884882 | 0.220267658405562 | 0.638601951285491 | 0.984006174272367 |
| Q6UWY0 | Q6UWY0 | ARSK_HUMAN | Arylsulfatase K (ASK) (EC 3.1.6.1) (Glucuronate-2-sulfatase) (EC 3.1.6.18) (Telethon sulfatase) | ARSK | endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; lysosome [GO:0005764] | arylsulfatase activity [GO:0004065]; glucuronate-2-sulfatase activity [GO:0015024]; metal ion binding [GO:0046872] | 9422.400186180039 | 0.157555068844968 | 0.640736811531685 | 0.984840940456461 | |
| Q9Y5P4 | Q9Y5P4 | CERT_HUMAN | Ceramide transfer protein (hCERT) (Collagen type IV alpha-3-binding protein) (Goodpasture antigen-binding protein) (GPBP) (START domain-containing protein 11) (StARD11) (StAR-related lipid transfer protein 11) | CERT1 | cell morphogenesis [GO:0000902]; cell population proliferation [GO:0008283]; ceramide metabolic process [GO:0006672]; ceramide transport [GO:0035627]; endoplasmic reticulum organization [GO:0007029]; ER to Golgi ceramide transport [GO:0035621]; heart morphogenesis [GO:0003007]; immune response [GO:0006955]; in utero embryonic development [GO:0001701]; intermembrane lipid transfer [GO:0120009]; intermembrane sphingolipid transfer [GO:0120012]; lipid homeostasis [GO:0055088]; mitochondrion organization [GO:0007005]; muscle contraction [GO:0006936]; response to endoplasmic reticulum stress [GO:0034976]; signal transduction [GO:0007165] | cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] | ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388]; ceramide binding [GO:0097001]; ceramide transfer activity [GO:0120017]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; phosphatidylinositol-4-phosphate binding [GO:0070273] | 9963.865083678615 | 0.0931383141814676 | 0.641019091452804 | 0.984840940456461 |
| Q9UEE9 | Q9UEE9 | CFDP1_HUMAN | Craniofacial development protein 1 (Bucentaur) | CFDP1 | cell adhesion [GO:0007155]; chromatin remodeling [GO:0006338]; fibroblast apoptotic process [GO:0044346]; negative regulation of fibroblast apoptotic process [GO:2000270]; regulation of cell population proliferation [GO:0042127]; regulation of cell shape [GO:0008360] | kinetochore [GO:0000776]; nucleus [GO:0005634]; Swr1 complex [GO:0000812] | 11842.29249921285 | 0.148162875347879 | 0.640267483599212 | 0.984840940456461 | |
| Q6UX04 | Q6UX04 | CWC27_HUMAN | Spliceosome-associated protein CWC27 homolog (Antigen NY-CO-10) (Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog) (PPIase CWC27) (Serologically defined colon cancer antigen 10) | CWC27 | mRNA splicing, via spliceosome [GO:0000398]; protein folding [GO:0006457] | catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; U2-type precatalytic spliceosome [GO:0071005] | 9447.32500897142 | 0.166631154456626 | 0.641278437233876 | 0.984840940456461 | |
| Q9NWV4 | Q9NWV4 | CZIB_HUMAN | CXXC motif containing zinc binding protein (UPF0587 protein C1orf123) | CZIB | zinc ion binding [GO:0008270] | 25892.1497365216 | 0.221169062115965 | 0.640620245679876 | 0.984840940456461 | ||
| Q1KMD3 | Q1KMD3 | HNRL2_HUMAN | Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) | HNRNPUL2 | membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202] | RNA binding [GO:0003723] | 44921.703082247855 | -0.134724904245791 | 0.64135768366657 | 0.984840940456461 | |
| Q9H6R4 | Q9H6R4 | NOL6_HUMAN | Nucleolar protein 6 (Nucleolar RNA-associated protein) (Nrap) | NOL6 | ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; tRNA export from nucleus [GO:0006409] | condensed nuclear chromosome [GO:0000794]; CURI complex [GO:0032545]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; UTP-C complex [GO:0034456] | RNA binding [GO:0003723] | 3473.3081809154946 | -0.226396338657503 | 0.639720660533412 | 0.984840940456461 |
| A6ZKI3 | A6ZKI3 | RTL8C_HUMAN | Retrotransposon Gag-like protein 8C (Mammalian retrotransposon derived protein 8C) | RTL8C | 48931.342694999155 | -0.0997258099458124 | 0.641113189839152 | 0.984840940456461 | |||
| Q9UBK9 | Q9UBK9 | UXT_HUMAN | Protein UXT (Androgen receptor trapped clone 27 protein) (ART-27) (Ubiquitously expressed transcript protein) | UXT | apoptotic process [GO:0006915]; centrosome cycle [GO:0007098]; microtubule cytoskeleton organization [GO:0000226]; mitochondrion transport along microtubule [GO:0047497]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein stabilization [GO:0050821] | centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]; spindle pole [GO:0000922] | beta-tubulin binding [GO:0048487]; chromatin binding [GO:0003682]; microtubule binding [GO:0008017]; transcription corepressor activity [GO:0003714] | 9521.664670739356 | -0.306851056644957 | 0.641380704250678 | 0.984840940456461 |
| Q9Y561 | Q9Y561 | LRP12_HUMAN | Low-density lipoprotein receptor-related protein 12 (LDLR-related protein 12) (LRP-12) (Suppressor of tumorigenicity 7 protein) | LRP12 | endocytosis [GO:0006897]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; regulation of growth [GO:0040008]; signal transduction [GO:0007165] | clathrin-coated pit [GO:0005905]; membrane [GO:0016020]; plasma membrane [GO:0005886] | low-density lipoprotein particle receptor activity [GO:0005041] | 12005.631263498 | -0.171139878403246 | 0.641646889233224 | 0.984982734867365 |
| Q99704 | Q99704 | DOK1_HUMAN | Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) | DOK1 | cell surface receptor signaling pathway [GO:0007166]; macrophage colony-stimulating factor signaling pathway [GO:0038145]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] | 9403.50815114805 | -0.190084935915351 | 0.642076528517511 | 0.985217076911967 | |
| Q96CN4 | Q96CN4 | EVI5L_HUMAN | EVI5-like protein (Ecotropic viral integration site 5-like protein) | EVI5L | negative regulation of cilium assembly [GO:1902018]; positive regulation of GTPase activity [GO:0043547] | GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] | 4010.65981106517 | 0.320761600514598 | 0.642147311160588 | 0.985217076911967 | |
| Q9NSY2 | Q9NSY2 | STAR5_HUMAN | StAR-related lipid transfer protein 5 (START domain-containing protein 5) (StARD5) | STARD5 | cholesterol import [GO:0070508] | cytosol [GO:0005829] | cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020] | 5097.294760847065 | -0.126789460965858 | 0.642920271330459 | 0.985916506456085 |
| O95163 | O95163 | ELP1_HUMAN | Elongator complex protein 1 (ELP1) (IkappaB kinase complex-associated protein) (IKK complex-associated protein) (p150) | ELP1 | regulation of translation [GO:0006417]; tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation [GO:0002926]; tRNA wobble uridine modification [GO:0002098] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; elongator holoenzyme complex [GO:0033588]; nucleus [GO:0005634] | protein self-association [GO:0043621]; tRNA binding [GO:0000049] | 5176.093231685731 | 0.162726140686748 | 0.643726734264265 | 0.986038301254752 |
| Q9BTY7 | Q9BTY7 | HGH1_HUMAN | Protein HGH1 homolog | HGH1 | 6682.746204055165 | -0.0971722158071263 | 0.643692749575526 | 0.986038301254752 | |||
| Q9NWT1 | Q9NWT1 | PK1IP_HUMAN | p21-activated protein kinase-interacting protein 1 (PAK/PLC-interacting protein 1) (hPIP1) (PAK1-interacting protein 1) (WD repeat-containing protein 84) | PAK1IP1 | cell population proliferation [GO:0008283]; negative regulation of signal transduction [GO:0009968]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit biogenesis [GO:0042273]; roof of mouth development [GO:0060021] | nucleolus [GO:0005730] | 4328.8167452729795 | -0.176902443684318 | 0.64409585935085 | 0.986337064616734 | |
| Q13561 | Q13561 | DCTN2_HUMAN | Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (p50 dynamitin) | DCTN2 | melanosome transport [GO:0032402]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle organization [GO:0007052]; protein localization to centrosome [GO:0071539] | centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; dynein complex [GO:0030286]; extracellular exosome [GO:0070062]; growth cone [GO:0030426]; kinetochore [GO:0000776]; membrane [GO:0016020]; microtubule [GO:0005874]; vesicle [GO:0031982] | identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; spectrin binding [GO:0030507] | 109921.76344413101 | 0.14149010408891 | 0.645497758473974 | 0.987963118431526 |
| Q9UPZ3 | Q9UPZ3 | HPS5_HUMAN | BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2) | HPS5 | blood coagulation [GO:0007596]; developmental pigmentation [GO:0048066]; intracellular transport [GO:0046907]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155] | BLOC-2 complex [GO:0031084]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769] | 6612.6003619394305 | -0.463946820936226 | 0.645506435657167 | 0.987963118431526 | |
| O00629 | O00629 | IMA3_HUMAN | Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4) | KPNA4 | dopamine secretion [GO:0014046]; gene expression [GO:0010467]; NLS-bearing protein import into nucleus [GO:0006607]; protein import into nucleus [GO:0006606] | cytosol [GO:0005829]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139] | 20403.83814829075 | 0.181533884456951 | 0.646822626987211 | 0.989443035774714 |
| Q8WWY3 | Q8WWY3 | PRP31_HUMAN | U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) (Serologically defined breast cancer antigen NY-BR-99) (U4/U6 snRNP 61 kDa protein) (Protein 61K) (hPrp31) | PRPF31 | mRNA splicing, via spliceosome [GO:0000398]; ribonucleoprotein complex localization [GO:0071166]; spliceosomal tri-snRNP complex assembly [GO:0000244] | Cajal body [GO:0015030]; MLL1 complex [GO:0071339]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal tri-snRNP complex [GO:0097526]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U4atac snRNP [GO:0005690] | identical protein binding [GO:0042802]; protein-macromolecule adaptor activity [GO:0030674]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; snRNP binding [GO:0070990]; U4 snRNA binding [GO:0030621]; U4atac snRNA binding [GO:0030622] | 12718.201710791549 | -0.0710221506237192 | 0.649012693295526 | 0.991722200704544 |
| Q00403 | Q00403 | TF2B_HUMAN | Transcription initiation factor IIB (EC 2.3.1.48) (General transcription factor TFIIB) (S300-II) | GTF2B | meiotic sister chromatid cohesion [GO:0051177]; positive regulation of core promoter binding [GO:1904798]; protein acetylation [GO:0006473]; RNA polymerase II core complex assembly [GO:1990114]; RNA polymerase II preinitiation complex assembly [GO:0051123]; spindle assembly [GO:0051225]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]; transcriptional start site selection at RNA polymerase II promoter [GO:0001174]; viral transcription [GO:0019083] | cell division site [GO:0032153]; chromosome [GO:0005694]; germinal vesicle [GO:0042585]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription factor TFIID complex [GO:0005669]; transcription preinitiation complex [GO:0097550] | acetyltransferase activity [GO:0016407]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; nuclear thyroid hormone receptor binding [GO:0046966]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II complex binding [GO:0000993]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; TBP-class protein binding [GO:0017025]; zinc ion binding [GO:0008270] | 4777.016648241575 | 0.310427114632111 | 0.649590318244828 | 0.992337218434941 |
| Q9H074 | Q9H074 | PAIP1_HUMAN | Polyadenylate-binding protein-interacting protein 1 (PABP-interacting protein 1) (PAIP-1) (Poly(A)-binding protein-interacting protein 1) | PAIP1 | CRD-mediated mRNA stabilization [GO:0070934]; mRNA stabilization [GO:0048255]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; positive regulation by host of viral process [GO:0044794]; positive regulation of cytoplasmic translation [GO:2000767]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]; viral translation [GO:0019081] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; mCRD-mediated mRNA stability complex [GO:0106002] | RNA binding [GO:0003723]; translation activator activity [GO:0008494] | 30842.61002982715 | -0.145402833339842 | 0.650024626304055 | 0.992733027665439 |
| Q9NUQ6 | Q9NUQ6 | SPS2L_HUMAN | SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) | SPATS2L | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991] | RNA binding [GO:0003723] | 24250.12829580345 | -0.100247980087028 | 0.65114672127557 | 0.994178745014114 | |
| Q9UII2 | Q9UII2 | ATIF1_HUMAN | ATPase inhibitor, mitochondrial (ATP synthase F1 subunit epsilon) (Inhibitor of F(1)F(o)-ATPase) (IF(1)) (IF1) | ATP5IF1 | angiogenesis [GO:0001525]; erythrocyte differentiation [GO:0030218]; generation of precursor metabolites and energy [GO:0006091]; heme biosynthetic process [GO:0006783]; mitochondrial depolarization [GO:0051882]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of hydrolase activity [GO:0051346]; positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization [GO:1904925]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of proteolysis involved in protein catabolic process [GO:1903052]; reactive oxygen species metabolic process [GO:0072593]; regulation of ATP metabolic process [GO:1903578]; regulation of protein targeting to mitochondrion [GO:1903214] | cell surface [GO:0009986]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991] | angiostatin binding [GO:0043532]; ATPase binding [GO:0051117]; ATPase inhibitor activity [GO:0042030]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; identical protein binding [GO:0042802]; mitochondrial proton-transporting ATP synthase complex binding [GO:0140260] | 62787.530399583455 | 0.203390447211812 | 0.652032401781084 | 0.994726868199145 |
A
B
C
D
E
F
G
H
I
J
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
| Q15149 | |||||||||
| Q99715 | |||||||||
| P02452 | |||||||||
| P02751 | |||||||||
| P98160 | |||||||||
| P08123 | |||||||||
| P02461 | |||||||||
| P07996 | |||||||||
| Q8WWI1 | |||||||||
| P05997 | |||||||||
| P20908 | |||||||||
| Q8WUJ3 | |||||||||
| P21333 | |||||||||
| O75369 | |||||||||
| Q15063 | |||||||||
| P02786 | |||||||||
| Q12884 | |||||||||
| P12814 | |||||||||
| Q9UDY2 | |||||||||
| Q14195 | |||||||||
| Q02952 | |||||||||
| Q9NZM1 | |||||||||
| P35579 | |||||||||
| P35354 | |||||||||
| P47895 | |||||||||
| Q09666 | |||||||||
| P11717 | |||||||||
| Q14112 | |||||||||
| Q13620 | |||||||||
| P43490 | |||||||||
| Q3SY69 | |||||||||
| P17812 | |||||||||
| P21980 | |||||||||
| Q16647 | |||||||||
| P01024 | |||||||||
| Q5SW79 | |||||||||
| P06396 | |||||||||
| P12111 | |||||||||
| P35221 | |||||||||
| P12429 | |||||||||
| P78559 | |||||||||
| Q76M96 | |||||||||
| Q16881 | |||||||||
| P07093 | |||||||||
| P27487 | |||||||||
| P15144 | |||||||||
| Q9H5V8 | |||||||||
| P08729 | |||||||||
| Q04828 | |||||||||
| O94925 | |||||||||
| P08473 | |||||||||
| Q8IVL5 | |||||||||
| P35442 | |||||||||
| O60716 | |||||||||
| P08253 | |||||||||
| Q16822 | |||||||||
| Q9UJ72 | |||||||||
| Q9Y617 | |||||||||
| Q8WX93 | |||||||||
| Q32MZ4 | |||||||||
| Q6P179 | |||||||||
| P48681 | |||||||||
| O95340 | |||||||||
| P21580 | |||||||||
| Q00341 | |||||||||
| P49748 | |||||||||
| O43854 | |||||||||
| P07942 | |||||||||
| Q96KC8 | |||||||||
| Q96PD2 | |||||||||
| Q13418 | |||||||||
| Q7Z7G0 | |||||||||
| Q04446 | |||||||||
| P19022 | |||||||||
| O00469 | |||||||||
| Q8WUF5 | |||||||||
| Q14767 | |||||||||
| Q13308 | |||||||||
| P46940 | |||||||||
| Q9NZ08 | |||||||||
| O60488 | |||||||||
| P35222 | |||||||||
| Q9H4M9 | |||||||||
| Q9NZU5 | |||||||||
| Q15113 | |||||||||
| O94808 | |||||||||
| Q9UI42 | |||||||||
| Q15417 | |||||||||
| Q15582 | |||||||||
| P35908 | |||||||||
| P00750 | |||||||||
| Q9UHD8 | |||||||||
| P11047 | |||||||||
| Q8N6G6 | |||||||||
| Q05682 | |||||||||
| P17342 | |||||||||
| Q16363 | |||||||||
| Q9NR12 | |||||||||
| P05362 | |||||||||
| P00966 | |||||||||
| P05120 | |||||||||
| P15121 | |||||||||
| P04179 | |||||||||
| Q15785 | |||||||||
| O60271 | |||||||||
| Q9Y6N5 | |||||||||
| Q9P0V9 | |||||||||
| Q8IVF2 | |||||||||
| P01584 | |||||||||
| Q96AQ6 | |||||||||
| P54289 | |||||||||
| P13667 | |||||||||
| Q96HE7 | |||||||||
| P21810 | |||||||||
| Q16790 | |||||||||
| P23396 | |||||||||
| P01130 | |||||||||
| P51812 | |||||||||
| O95490 | |||||||||
| Q16222 | |||||||||
| Q7Z4N8 | |||||||||
| P08133 | |||||||||
| Q08431 | |||||||||
| P23142 | |||||||||
| Q01581 | |||||||||
| P10915 | |||||||||
| O75976 | |||||||||
| P23219 | |||||||||
| Q8IXK2 | |||||||||
| Q07954 | |||||||||
| P50225 | |||||||||
| P11413 | |||||||||
| Q5SSJ5 | |||||||||
| Q6PCE3 | |||||||||
| P05091 | |||||||||
| P49419 | |||||||||
| P41252 | |||||||||
| P50281 | |||||||||
| Q13618 | |||||||||
| Q00653 | |||||||||
| Q9BZG1 | |||||||||
| P11142 | |||||||||
| P63010 | |||||||||
| Q9UBG0 | |||||||||
| Q5GLZ8 | |||||||||
| P21266 | |||||||||
| Q9BS40 | |||||||||
| P35232 | |||||||||
| Q86VP6 | |||||||||
| P09601 | |||||||||
| Q8N8S7 | |||||||||
| Q16851 | |||||||||
| P28845 | |||||||||
| P26640 | |||||||||
| Q92626 | |||||||||
| P07686 | |||||||||
| P01583 | |||||||||
| Q96HH9 | |||||||||
| P48506 | |||||||||
| P47712 | |||||||||
| Q14314 | |||||||||
| Q53FA7 | |||||||||
| Q9H425 | |||||||||
| Q14204 | |||||||||
| P01033 | |||||||||
| Q92616 | |||||||||
| Q16666 | |||||||||
| Q99623 | |||||||||
| P23381 | |||||||||
| Q8N6Y2 | |||||||||
| P98155 | |||||||||
| P46977 | |||||||||
| Q86SQ0 | |||||||||
| Q70E73 | |||||||||
| Q6VY07 | |||||||||
| P41250 | |||||||||
| P56945 | |||||||||
| P29279 | |||||||||
| Q96C19 | |||||||||
| Q9UPN3 | |||||||||
| P26022 | |||||||||
| P00492 | |||||||||
| Q9BXS4 | |||||||||
| P50452 | |||||||||
| P05783 | |||||||||
| Q14980 | |||||||||
| Q9UBX5 | |||||||||
| O75094 | |||||||||
| Q06323 | |||||||||
| O14672 | |||||||||
| O00339 | |||||||||
| P52209 | |||||||||
| Q00325 | |||||||||
| P30044 | |||||||||
| P30740 | |||||||||
| P46734 | |||||||||
| P48307 | |||||||||
| P08648 | |||||||||
| O43175 | |||||||||
| O00116 |
