Selected Cell
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stat_data__min_2_Peptides
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| P13473 | P13473 | LAMP2_HUMAN | Lysosome-associated membrane glycoprotein 2 (LAMP-2) (Lysosome-associated membrane protein 2) (CD107 antigen-like family member B) (LGP-96) (CD antigen CD107b) | LAMP2 | autophagosome maturation [GO:0097352]; cellular response to starvation [GO:0009267]; chaperone-mediated autophagy [GO:0061684]; lysosomal lumen acidification [GO:0007042]; lysosomal protein catabolic process [GO:1905146]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of protein-containing complex assembly [GO:0031333]; protein catabolic process [GO:0030163]; protein import [GO:0017038]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; protein targeting to lysosome involved in chaperone-mediated autophagy [GO:0061740]; regulation of protein stability [GO:0031647] | autolysosome [GO:0044754]; autophagosome membrane [GO:0000421]; azurophil granule membrane [GO:0035577]; chaperone-mediated autophagy translocation complex [GO:0061742]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; platelet dense granule membrane [GO:0031088]; trans-Golgi network [GO:0005802] | enzyme binding [GO:0019899]; ion channel inhibitor activity [GO:0008200]; protein domain specific binding [GO:0019904]; signaling adaptor activity [GO:0035591] | 239739.171115065 | 0.261502508557013 | 0.37891162455471 | 0.727274141167678 |
| A5D8V6 | A5D8V6 | VP37C_HUMAN | Vacuolar protein sorting-associated protein 37C (hVps37C) (ESCRT-I complex subunit VPS37C) | VPS37C | macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein targeting to membrane [GO:0006612]; protein targeting to vacuole [GO:0006623]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding via host ESCRT complex [GO:0039702] | endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902] | calcium-dependent protein binding [GO:0048306] | 12036.5680861985 | 0.174989822917846 | 0.378817191189144 | 0.727274141167678 |
| Q92576 | Q92576 | PHF3_HUMAN | PHD finger protein 3 | PHF3 | DNA-templated transcription [GO:0006351] | nucleus [GO:0005634] | metal ion binding [GO:0046872] | 6303.2832666934955 | -1.44788365665109 | 0.38029343150644 | 0.729185307247205 |
| Q9Y2G3 | Q9Y2G3 | AT11B_HUMAN | Phospholipid-transporting ATPase IF (EC 7.6.2.1) (ATPase IR) (ATPase class VI type 11B) (P4-ATPase flippase complex alpha subunit ATP11B) | ATP11B | aminophospholipid transport [GO:0015917]; monoatomic ion transmembrane transport [GO:0034220]; monoatomic ion transport [GO:0006811]; phospholipid translocation [GO:0045332] | azurophil granule membrane [GO:0035577]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287]; monoatomic ion transmembrane transporter activity [GO:0015075]; phosphatidylethanolamine flippase activity [GO:0090555]; phosphatidylserine floppase activity [GO:0090556] | 6880.193139802905 | -0.235803585337169 | 0.380698013395535 | 0.72946734660098 |
| Q96HD1 | Q96HD1 | CREL1_HUMAN | Protein disulfide isomerase CRELD1 (EC 5.3.4.1) (Cysteine-rich with EGF-like domain protein 1) | CRELD1 | cardiac septum development [GO:0003279]; endocardial cushion development [GO:0003197] | collagen-containing extracellular matrix [GO:0062023]; membrane [GO:0016020] | calcium ion binding [GO:0005509]; protein disulfide isomerase activity [GO:0003756] | 16662.9305062366 | 0.237516919284676 | 0.381268036037487 | 0.730065796616561 |
| Q99571 | Q99571 | P2RX4_HUMAN | P2X purinoceptor 4 (P2X4) (ATP receptor) (Purinergic receptor) | P2RX4 | apoptotic signaling pathway [GO:0097190]; behavioral response to pain [GO:0048266]; calcium ion transmembrane transport [GO:0070588]; calcium-mediated signaling [GO:0019722]; cellular response to ATP [GO:0071318]; cellular response to zinc ion [GO:0071294]; endothelial cell activation [GO:0042118]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; neuronal action potential [GO:0019228]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of microglial cell migration [GO:1904141]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of prostaglandin secretion [GO:0032308]; purinergic nucleotide receptor signaling pathway [GO:0035590]; regulation of blood pressure [GO:0008217]; regulation of cardiac muscle contraction [GO:0055117]; regulation of chemotaxis [GO:0050920]; regulation of sodium ion transport [GO:0002028]; relaxation of cardiac muscle [GO:0055119]; response to ATP [GO:0033198]; response to axon injury [GO:0048678]; response to fluid shear stress [GO:0034405]; response to ischemia [GO:0002931]; sensory perception of pain [GO:0019233]; sensory perception of touch [GO:0050975]; signal transduction [GO:0007165]; tissue homeostasis [GO:0001894] | cell body [GO:0044297]; cell junction [GO:0030054]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; terminal bouton [GO:0043195] | ATP binding [GO:0005524]; cadherin binding [GO:0045296]; copper ion binding [GO:0005507]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; identical protein binding [GO:0042802]; ligand-gated calcium channel activity [GO:0099604]; purinergic nucleotide receptor activity [GO:0001614]; signaling receptor binding [GO:0005102]; zinc ion binding [GO:0008270] | 3708.482003128845 | 0.258320472197393 | 0.381185545982985 | 0.730065796616561 |
| Q6ZPD9 | Q6ZPD9 | D19L3_HUMAN | Protein C-mannosyl-transferase DPY19L3 (EC 2.4.1.-) (Dpy-19-like protein 3) (Protein dpy-19 homolog 3) | DPY19L3 | protein glycosylation [GO:0006486] | endoplasmic reticulum membrane [GO:0005789]; nuclear inner membrane [GO:0005637] | mannosyltransferase activity [GO:0000030] | 3292.413745949425 | -1.50280904498376 | 0.38208173806227 | 0.731213713567709 |
| Q96SK2 | Q96SK2 | TM209_HUMAN | Transmembrane protein 209 | TMEM209 | Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nuclear envelope [GO:0005635] | 3264.77112936233 | -0.395285974162738 | 0.383164334658877 | 0.732742695400032 | ||
| Q9Y3D2 | Q9Y3D2 | MSRB2_HUMAN | Methionine-R-sulfoxide reductase B2, mitochondrial (MsrB2) (EC 1.8.4.12) (EC 1.8.4.14) | MSRB2 | actin filament polymerization [GO:0030041]; protein repair [GO:0030091]; response to oxidative stress [GO:0006979] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739] | actin binding [GO:0003779]; L-methionine-(R)-S-oxide reductase activity [GO:0033745]; peptide-methionine (R)-S-oxide reductase activity [GO:0033743]; zinc ion binding [GO:0008270] | 22489.8881265062 | 0.186571161767166 | 0.383624135643817 | 0.73333817562681 |
| Q6WCQ1 | Q6WCQ1 | MPRIP_HUMAN | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | MPRIP | actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; focal adhesion [GO:0005925] | actin filament binding [GO:0051015]; cadherin binding [GO:0045296] | 19235.6374166069 | -0.139607720394096 | 0.384168986865529 | 0.733884517727609 | |
| Q6NW29 | Q6NW29 | RWDD4_HUMAN | RWD domain-containing protein 4 (Protein FAM28A) | RWDD4 | 10061.54620299675 | 0.211378616659858 | 0.384057641858002 | 0.733884517727609 | |||
| O00567 | O00567 | NOP56_HUMAN | Nucleolar protein 56 (Nucleolar protein 5A) | NOP56 | ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364] | box C/D RNP complex [GO:0031428]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; pre-snoRNP complex [GO:0070761]; small-subunit processome [GO:0032040]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732] | cadherin binding [GO:0045296]; histone methyltransferase binding [GO:1990226]; RNA binding [GO:0003723]; snoRNA binding [GO:0030515] | 36518.0992607541 | -0.10214329578124 | 0.384571145807236 | 0.73440516081692 |
| P46939 | P46939 | UTRN_HUMAN | Utrophin (Dystrophin-related protein 1) (DRP-1) | UTRN | muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; positive regulation of cell-matrix adhesion [GO:0001954]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; synaptic signaling [GO:0099536] | cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; filopodium membrane [GO:0031527]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383] | actin binding [GO:0003779]; integrin binding [GO:0005178]; protein kinase binding [GO:0019901]; vinculin binding [GO:0017166]; zinc ion binding [GO:0008270] | 13455.927616726 | -0.22585257353751 | 0.385429005150488 | 0.73579539864645 |
| Q9GZU1 | Q9GZU1 | MCLN1_HUMAN | Mucolipin-1 (ML1) (MG-2) (Mucolipidin) (Transient receptor potential channel mucolipin 1) (TRPML1) | MCOLN1 | adaptive immune response [GO:0002250]; autophagosome maturation [GO:0097352]; calcium ion export [GO:1901660]; calcium ion transmembrane transport [GO:0070588]; cellular response to calcium ion [GO:0071277]; cellular response to pH [GO:0071467]; localization [GO:0051179]; monoatomic cation transport [GO:0006812]; phagosome maturation [GO:0090382]; positive regulation of lysosome organization [GO:1905673]; protein homotetramerization [GO:0051289]; release of sequestered calcium ion into cytosol [GO:0051209]; transferrin transport [GO:0033572] | cell projection [GO:0042995]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; phagocytic cup [GO:0001891]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] | calcium channel activity [GO:0005262]; identical protein binding [GO:0042802]; intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity [GO:0097682]; iron ion transmembrane transporter activity [GO:0005381]; ligand-gated calcium channel activity [GO:0099604]; lipid binding [GO:0008289]; monoatomic cation channel activity [GO:0005261]; NAADP-sensitive calcium-release channel activity [GO:0072345] | 7661.42146028772 | -0.20667131048423 | 0.385800527920019 | 0.735803729199946 |
| P53602 | P53602 | MVD1_HUMAN | Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase) | MVD | cholesterol biosynthetic process [GO:0006695]; isopentenyl diphosphate biosynthetic process, mevalonate pathway [GO:0019287]; isoprenoid biosynthetic process [GO:0008299]; positive regulation of cell population proliferation [GO:0008284] | cytosol [GO:0005829] | ATP binding [GO:0005524]; diphosphomevalonate decarboxylase activity [GO:0004163]; Hsp70 protein binding [GO:0030544]; protein homodimerization activity [GO:0042803] | 24536.68254372805 | 0.157077524856957 | 0.38569580656255 | 0.735803729199946 |
| P11166 | P11166 | GTR1_HUMAN | Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (HepG2 glucose transporter) | SLC2A1 | cellular hyperosmotic response [GO:0071474]; cellular response to glucose starvation [GO:0042149]; cellular response to mechanical stimulus [GO:0071260]; central nervous system development [GO:0007417]; cerebral cortex development [GO:0021987]; dehydroascorbic acid transport [GO:0070837]; female pregnancy [GO:0007565]; glucose import [GO:0046323]; glucose import across plasma membrane [GO:0098708]; glucose transmembrane transport [GO:1904659]; L-ascorbic acid metabolic process [GO:0019852]; long-chain fatty acid import across plasma membrane [GO:0015911]; photoreceptor cell maintenance [GO:0045494]; protein-containing complex assembly [GO:0065003]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to Thyroglobulin triiodothyronine [GO:1904016]; transport across blood-brain barrier [GO:0150104] | apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; blood microparticle [GO:0072562]; caveola [GO:0005901]; cortical actin cytoskeleton [GO:0030864]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; female germ cell nucleus [GO:0001674]; female pronucleus [GO:0001939]; glucose transporter complex [GO:1990350]; Golgi membrane [GO:0000139]; intercalated disc [GO:0014704]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; sarcolemma [GO:0042383]; Z disc [GO:0030018] | D-glucose transmembrane transporter activity [GO:0055056]; dehydroascorbic acid transmembrane transporter activity [GO:0033300]; glucose transmembrane transporter activity [GO:0005355]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; long-chain fatty acid transporter activity [GO:0005324]; protein self-association [GO:0043621]; xenobiotic transmembrane transporter activity [GO:0042910] | 42778.1093758153 | -0.101855252268458 | 0.386139621351563 | 0.736159856856648 |
| P36639 | P36639 | 8ODP_HUMAN | Oxidized purine nucleoside triphosphate hydrolase (EC 3.6.1.56) (2-hydroxy-dATP diphosphatase) (7,8-dihydro-8-oxoguanine triphosphatase) (8-oxo-dGTPase) (Methylated purine nucleoside triphosphate hydrolase) (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 1) (Nudix motif 1) | NUDT1 | DNA protection [GO:0042262]; DNA repair [GO:0006281]; male gonad development [GO:0008584]; purine nucleoside catabolic process [GO:0006152]; response to cadmium ion [GO:0046686]; response to oxidative stress [GO:0006979] | acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleus [GO:0005634] | 2-hydroxy-ATP hydrolase activity [GO:0106377]; 2-hydroxy-dATP hydrolase activity [GO:0106378]; 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity [GO:0035539]; 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity [GO:0008413]; ATP diphosphatase activity [GO:0047693]; dATP diphosphatase activity [GO:0008828]; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]; metal ion binding [GO:0046872]; N6-methyl-(d)ATP hydrolase activity [GO:0106431]; O6-methyl-dGTP hydrolase activity [GO:0106433]; snoRNA binding [GO:0030515] | 23660.4203757098 | 0.213916080821047 | 0.38710878531071 | 0.737756180249592 |
| Q93096 | Q93096 | TP4A1_HUMAN | Protein tyrosine phosphatase type IVA 1 (EC 3.1.3.48) (PTP(CAAXI)) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1) | PTP4A1 | cell cycle [GO:0007049]; dephosphorylation [GO:0016311]; positive regulation of cell migration [GO:0030335] | cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; spindle [GO:0005819] | protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138] | 5959.542874040735 | -0.211993566235496 | 0.38743592620987 | 0.737756180249592 |
| Q96DM3 | Q96DM3 | RMC1_HUMAN | Regulator of MON1-CCZ1 complex (Colon cancer-associated protein Mic1) (Mic-1) (WD repeat-containing protein 98) | RMC1 | autophagy [GO:0006914]; regulation of autophagy [GO:0010506] | late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; Mon1-Ccz1 complex [GO:0035658] | 5363.342836747755 | -0.215102413150342 | 0.387497774871653 | 0.737756180249592 | |
| P23497 | P23497 | SP100_HUMAN | Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) | SP100 | DNA damage response, signal transduction by p53 class mediator [GO:0030330]; maintenance of protein location [GO:0045185]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of protein export from nucleus [GO:0046826]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of viral transcription [GO:0032897]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of angiogenesis [GO:0045765]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of Fas signaling pathway [GO:1902044]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cytokine [GO:0034097]; response to retinoic acid [GO:0032526]; response to type I interferon [GO:0034340]; response to type II interferon [GO:0034341]; retinoic acid receptor signaling pathway [GO:0048384]; telomere maintenance [GO:0000723]; type I interferon-mediated signaling pathway [GO:0060337]; type II interferon-mediated signaling pathway [GO:0060333] | chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nuclear periphery [GO:0034399]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] | chromo shadow domain binding [GO:0070087]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; protein dimerization activity [GO:0046983]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] | 32016.75588179 | -0.099425987589467 | 0.387335801701347 | 0.737756180249592 |
| A6NFQ2 | A6NFQ2 | TCAF2_HUMAN | TRPM8 channel-associated factor 2 (TRP channel-associated factor 2) | TCAF2 | negative regulation of anion channel activity [GO:0010360]; positive regulation of cell migration [GO:0030335]; positive regulation of protein targeting to membrane [GO:0090314] | cell junction [GO:0030054]; plasma membrane [GO:0005886] | transmembrane transporter binding [GO:0044325] | 8356.972355898624 | 1.16547863382202 | 0.387855394475112 | 0.738189004063146 |
| Q7Z4S6 | Q7Z4S6 | KI21A_HUMAN | Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) | KIF21A | microtubule-based movement [GO:0007018]; mitotic spindle organization [GO:0007052]; spindle elongation [GO:0051231] | axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; kinesin complex [GO:0005871]; microtubule [GO:0005874] | ankyrin repeat binding [GO:0071532]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] | 4223.523943444405 | -0.468408536403525 | 0.388555050676406 | 0.739024141367075 |
| Q16563 | Q16563 | SYPL1_HUMAN | Synaptophysin-like protein 1 (Pantophysin) | SYPL1 | chemical synaptic transmission [GO:0007268] | extracellular exosome [GO:0070062]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; synaptic vesicle membrane [GO:0030672] | 307934.71950491355 | 0.170549128199513 | 0.388491428655356 | 0.739024141367075 | |
| Q9P0M9 | Q9P0M9 | RM27_HUMAN | Large ribosomal subunit protein bL27m (39S ribosomal protein L27, mitochondrial) (L27mt) (MRP-L27) | MRPL27 | mitochondrial translation [GO:0032543]; translation [GO:0006412] | cytosolic large ribosomal subunit [GO:0022625]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 9043.161058196454 | 0.244567593193185 | 0.388985262849295 | 0.739594127283258 |
| O95478 | O95478 | NSA2_HUMAN | Ribosome biogenesis protein NSA2 homolog (Hairy cell leukemia protein 1) (TGF-beta-inducible nuclear protein 1) | NSA2 | maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470] | nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687] | RNA binding [GO:0003723] | 9648.69027942691 | 0.243048034546324 | 0.38959789685595 | 0.740013973712978 |
| Q7Z4H8 | Q7Z4H8 | PLGT3_HUMAN | Protein O-glucosyltransferase 3 (EC 2.4.1.-) (KDEL motif-containing protein 2) (Protein O-xylosyltransferase POGLUT3) (EC 2.4.2.-) | POGLUT3 | protein O-linked glycosylation via serine [GO:0018242] | endomembrane system [GO:0012505]; endoplasmic reticulum lumen [GO:0005788] | EGF-domain serine glucosyltransferase activity [GO:0140561]; EGF-domain serine xylosyltransferase activity [GO:0140562]; glucosyltransferase activity [GO:0046527]; UDP-glucosyltransferase activity [GO:0035251]; UDP-xylosyltransferase activity [GO:0035252] | 27354.310241533698 | 0.123776637227087 | 0.389535928629411 | 0.740013973712978 |
| O00471 | O00471 | EXOC5_HUMAN | Exocyst complex component 5 (Exocyst complex component Sec10) (hSec10) | EXOC5 | epithelial cell apoptotic process [GO:1904019]; establishment of planar polarity [GO:0001736]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; non-motile cilium assembly [GO:1905515]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; exocyst [GO:0000145]; midbody [GO:0030496] | small GTPase binding [GO:0031267] | 15053.9123509013 | -0.140655493044197 | 0.389881026995214 | 0.740303585440644 |
| P07437 | P07437 | TBB5_HUMAN | Tubulin beta chain (Tubulin beta-5 chain) | TUBB | cell division [GO:0051301]; cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]; natural killer cell mediated cytotoxicity [GO:0042267]; odontoblast differentiation [GO:0071895]; regulation of synapse organization [GO:0050807]; spindle assembly [GO:0051225] | azurophil granule lumen [GO:0035578]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intercellular bridge [GO:0045171]; membrane raft [GO:0045121]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nuclear envelope lumen [GO:0005641]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] | GTP binding [GO:0005525]; GTPase activating protein binding [GO:0032794]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; MHC class I protein binding [GO:0042288]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; ubiquitin protein ligase binding [GO:0031625] | 2201909.6712044952 | 0.0645383291137071 | 0.390339265220447 | 0.740925385842228 |
| O95400 | O95400 | CD2B2_HUMAN | CD2 antigen cytoplasmic tail-binding protein 2 (CD2 cytoplasmic domain-binding protein 2) (CD2 tail-binding protein 2) (U5 snRNP 52K protein) (U5-52K) | CD2BP2 | spliceosomal tri-snRNP complex assembly [GO:0000244] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U5 snRNP [GO:0005682] | ribonucleoprotein complex binding [GO:0043021] | 22812.7530118607 | 0.214278570342875 | 0.391871274419432 | 0.743549266677927 |
| Q06546 | Q06546 | GABPA_HUMAN | GA-binding protein alpha chain (GABP subunit alpha) (Nuclear respiratory factor 2 subunit alpha) (Transcription factor E4TF1-60) | GABPA | blastocyst formation [GO:0001825]; cell differentiation [GO:0030154]; negative regulation of megakaryocyte differentiation [GO:0045653]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] | chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976] | 3140.431683645295 | -1.26516406492719 | 0.391984055694841 | 0.743549266677927 |
| Q9H6U8 | Q9H6U8 | ALG9_HUMAN | Alpha-1,2-mannosyltransferase ALG9 (EC 2.4.1.259) (EC 2.4.1.261) (Asparagine-linked glycosylation protein 9 homolog) (Disrupted in bipolar disorder protein 1) (Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase) (Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase) | ALG9 | dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein N-linked glycosylation [GO:0006487] | endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] | alpha-1,2-mannosyltransferase activity [GO:0000026]; dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity [GO:0052926]; dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity [GO:0052918] | 11845.805715530449 | -0.202660869771286 | 0.392468930703244 | 0.743970880349475 |
| Q9Y5Q8 | Q9Y5Q8 | TF3C5_HUMAN | General transcription factor 3C polypeptide 5 (TF3C-epsilon) (Transcription factor IIIC 63 kDa subunit) (TFIIIC 63 kDa subunit) (TFIIIC63) (Transcription factor IIIC subunit epsilon) | GTF3C5 | 5S class rRNA transcription by RNA polymerase III [GO:0042791]; skeletal muscle cell differentiation [GO:0035914]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase III promoter [GO:0006384]; tRNA transcription by RNA polymerase III [GO:0042797] | nucleoplasm [GO:0005654]; transcription factor TFIIIC complex [GO:0000127] | RNA polymerase III general transcription initiation factor activity [GO:0000995]; RNA polymerase III type 1 promoter sequence-specific DNA binding [GO:0001002]; RNA polymerase III type 2 promoter sequence-specific DNA binding [GO:0001003] | 4765.633072560765 | -0.234852068421265 | 0.393342415669667 | 0.745128093341468 |
| Q15070 | Q15070 | OXA1L_HUMAN | Mitochondrial inner membrane protein OXA1L (OXA1Hs) (Oxidase assembly 1-like protein) (OXA1-like protein) | OXA1L | aerobic respiration [GO:0009060]; mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]; mitochondrial respiratory chain complex I assembly [GO:0032981]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of oxidoreductase activity [GO:0051354]; protein insertion into mitochondrial inner membrane from matrix [GO:0032979]; protein tetramerization [GO:0051262] | mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991] | membrane insertase activity [GO:0032977]; mitochondrial ribosome binding [GO:0097177]; protein homodimerization activity [GO:0042803] | 13564.884105815501 | -0.2920877577591 | 0.394894018607258 | 0.747567493962152 |
| Q9Y5Z4 | Q9Y5Z4 | HEBP2_HUMAN | Heme-binding protein 2 (Placental protein 23) (PP23) (Protein SOUL) | HEBP2 | azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; mitochondrion [GO:0005739] | heme binding [GO:0020037] | 155938.78844016348 | 0.22525201864812 | 0.395123419200394 | 0.747751934933009 | |
| P30039 | P30039 | PBLD_HUMAN | Phenazine biosynthesis-like domain-containing protein (EC 5.1.-.-) (MAWD-binding protein) (MAWDBP) (Unknown protein 32 from 2D-page of liver tissue) | PBLD | biosynthetic process [GO:0009058]; maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512] | cytoplasm [GO:0005737]; extracellular exosome [GO:0070062] | identical protein binding [GO:0042802]; isomerase activity [GO:0016853] | 7260.27308536072 | -0.159038788951545 | 0.39564537336591 | 0.748317855823392 |
| P11169 | P11169 | GTR3_HUMAN | Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain) (GLUT-3) | SLC2A3 | carbohydrate metabolic process [GO:0005975]; dehydroascorbic acid transport [GO:0070837]; galactose transmembrane transport [GO:0015757]; glucose import [GO:0046323]; glucose import across plasma membrane [GO:0098708]; glucose transmembrane transport [GO:1904659]; L-ascorbic acid metabolic process [GO:0019852]; transport across blood-brain barrier [GO:0150104] | aggresome [GO:0016235]; cell projection [GO:0042995]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] | D-glucose transmembrane transporter activity [GO:0055056]; dehydroascorbic acid transmembrane transporter activity [GO:0033300]; galactose transmembrane transporter activity [GO:0005354]; glucose binding [GO:0005536]; glucose transmembrane transporter activity [GO:0005355] | 20253.02286124775 | -0.119230503631808 | 0.395932544772709 | 0.748533132693416 |
| Q8WZA0 | Q8WZA0 | LZIC_HUMAN | Protein LZIC (Leucine zipper and CTNNBIP1 domain-containing protein) (Leucine zipper and ICAT homologous domain-containing protein) | LZIC | beta-catenin binding [GO:0008013] | 21384.981702700003 | 0.23687301534947 | 0.396083909102564 | 0.748569522673492 | ||
| Q9UBB4 | Q9UBB4 | ATX10_HUMAN | Ataxin-10 (Brain protein E46 homolog) (Spinocerebellar ataxia type 10 protein) | ATXN10 | cilium assembly [GO:0060271]; nervous system development [GO:0007399]; neuron projection development [GO:0031175]; regulation of cytokinesis [GO:0032465] | centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular space [GO:0005615]; membrane [GO:0016020]; midbody [GO:0030496]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] | 12938.15017604565 | 0.0474773418781698 | 0.396230973052149 | 0.748597763692389 | |
| Q96I25 | Q96I25 | SPF45_HUMAN | Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17) | RBM17 | alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA cis splicing, via spliceosome [GO:0045292] | nucleoplasm [GO:0005654]; precatalytic spliceosome [GO:0071011] | RNA binding [GO:0003723] | 14127.0376481605 | 0.144037762509866 | 0.397608127933447 | 0.75069898462876 |
| Q9NP66 | Q9NP66 | HM20A_HUMAN | High mobility group protein 20A (HMG box-containing protein 20A) (HMG domain-containing protein 1) (HMG domain-containing protein HMGX1) | HMG20A | chromatin organization [GO:0006325]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468] | nucleus [GO:0005634] | DNA binding [GO:0003677]; identical protein binding [GO:0042802] | 3554.477873759855 | 0.392105790508078 | 0.397888525538241 | 0.750978143137799 |
| P48509 | P48509 | CD151_HUMAN | CD151 antigen (GP27) (Membrane glycoprotein SFA-1) (Platelet-endothelial tetraspan antigen 3) (PETA-3) (Tetraspanin-24) (Tspan-24) (CD antigen CD151) | CD151 | cell adhesion [GO:0007155]; cell migration [GO:0016477]; positive regulation of cell migration [GO:0030335]; positive regulation of endocytosis [GO:0045807]; T cell proliferation [GO:0042098]; wound healing, spreading of cells [GO:0044319] | basement membrane [GO:0005604]; cell surface [GO:0009986]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886] | integrin binding [GO:0005178] | 189948.4399668015 | -0.154130722579074 | 0.398022724402814 | 0.750981270884563 |
| P82930 | P82930 | RT34_HUMAN | Small ribosomal subunit protein mS34 (28S ribosomal protein S34, mitochondrial) (MRP-S34) (S34mt) | MRPS34 | mitochondrial translation [GO:0032543] | mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] | structural constituent of ribosome [GO:0003735] | 8275.583992312144 | 0.244672359103909 | 0.398746064550974 | 0.75209560644002 |
| Q66PJ3 | Q66PJ3 | AR6P4_HUMAN | ADP-ribosylation factor-like protein 6-interacting protein 4 (ARL-6-interacting protein 4) (Aip-4) (HSP-975) (HSVI-binding protein) (SR-15) (SRp25) (SR-25) (Splicing factor SRrp37) | ARL6IP4 | mRNA processing [GO:0006397]; RNA splicing [GO:0008380] | nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634] | RNA binding [GO:0003723] | 13695.76986541765 | 0.309097997932475 | 0.399592807293768 | 0.753191232909677 |
| O95149 | O95149 | SPN1_HUMAN | Snurportin-1 (RNA U transporter 1) | SNUPN | protein import into nucleus [GO:0006606]; RNA import into nucleus [GO:0006404]; snRNA import into nucleus [GO:0061015] | cytosol [GO:0005829]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] | nuclear import signal receptor activity [GO:0061608]; RNA cap binding [GO:0000339] | 10021.154437829431 | 0.177801687562345 | 0.400186507926429 | 0.75405944592988 |
| Q6PD74 | Q6PD74 | AAGAB_HUMAN | Alpha- and gamma-adaptin-binding protein p34 | AAGAB | protein transport [GO:0015031] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607] | 10024.936554635744 | 0.239749459827341 | 0.401503010914345 | 0.755340212048855 | |
| Q9Y624 | Q9Y624 | JAM1_HUMAN | Junctional adhesion molecule A (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet F11 receptor) (Platelet adhesion molecule 1) (PAM-1) (CD antigen CD321) | F11R | actomyosin structure organization [GO:0031032]; cell-cell adhesion [GO:0098609]; cellular response to mechanical stimulus [GO:0071260]; establishment of endothelial intestinal barrier [GO:0090557]; inflammatory response [GO:0006954]; intestinal absorption [GO:0050892]; leukocyte cell-cell adhesion [GO:0007159]; maintenance of blood-brain barrier [GO:0035633]; memory T cell extravasation [GO:0035683]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of establishment of endothelial barrier [GO:1903142]; positive regulation of platelet aggregation [GO:1901731]; positive regulation of Rho protein signal transduction [GO:0035025]; protein localization to bicellular tight junction [GO:1902396]; protein localization to plasma membrane [GO:0072659]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of cell shape [GO:0008360]; regulation of cytokine production [GO:0001817]; regulation of cytoskeleton organization [GO:0051493]; regulation of membrane permeability [GO:0090559] | bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; tight junction [GO:0070160] | cadherin binding [GO:0045296]; integrin binding [GO:0005178]; PDZ domain binding [GO:0030165]; protein homodimerization activity [GO:0042803]; virus receptor activity [GO:0001618] | 10340.16770292635 | 0.280760764356027 | 0.401666088758066 | 0.755340212048855 |
| Q8NG68 | Q8NG68 | TTL_HUMAN | Tubulin--tyrosine ligase (TTL) (EC 6.3.2.25) | TTL | microtubule cytoskeleton organization [GO:0000226]; positive regulation of mitotic cell cycle [GO:0045931]; post-translational protein modification [GO:0043687]; regulation of axon extension [GO:0030516]; regulation of metaphase plate congression [GO:0090235] | spindle microtubule [GO:0005876] | ATP binding [GO:0005524]; tubulin-tyrosine ligase activity [GO:0004835] | 7765.41198180332 | 0.3143649793519 | 0.401290454765712 | 0.755340212048855 |
| Q99536 | Q99536 | VAT1_HUMAN | Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-) | VAT1 | negative regulation of mitochondrial fusion [GO:0010637] | azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741] | oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270] | 222735.8359758715 | 0.0712169713869886 | 0.401254824128017 | 0.755340212048855 |
| O43504 | O43504 | LTOR5_HUMAN | Ragulator complex protein LAMTOR5 (Hepatitis B virus X-interacting protein) (HBV X-interacting protein) (HBX-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5) | LAMTOR5 | cellular response to amino acid stimulus [GO:0071230]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1905636]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; protein localization to lysosome [GO:0061462]; regulation of cell size [GO:0008361]; response to virus [GO:0009615]; TORC1 signaling [GO:0038202]; viral genome replication [GO:0019079] | cytosol [GO:0005829]; FNIP-folliculin RagC/D GAP [GO:1990877]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; protein-containing complex [GO:0032991]; Ragulator complex [GO:0071986] | guanyl-nucleotide exchange factor activity [GO:0005085] | 36652.7719358185 | -0.12754674998987 | 0.401931896978199 | 0.755589292726767 |
| P35318 | P35318 | ADML_HUMAN | Pro-adrenomedullin [Cleaved into: Adrenomedullin (AM); Proadrenomedullin N-20 terminal peptide (ProAM N-terminal 20 peptide) (PAMP) (ProAM-N20)] | ADM | adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adrenomedullin receptor signaling pathway [GO:1990410]; androgen metabolic process [GO:0008209]; animal organ regeneration [GO:0031100]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; cAMP-mediated signaling [GO:0019933]; cell population proliferation [GO:0008283]; developmental growth [GO:0048589]; female pregnancy [GO:0007565]; G protein-coupled receptor internalization [GO:0002031]; heart development [GO:0007507]; inflammatory response [GO:0006954]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of vascular permeability [GO:0043116]; negative regulation of vasoconstriction [GO:0045906]; neural tube closure [GO:0001843]; neuron projection regeneration [GO:0031102]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of heart rate [GO:0010460]; positive regulation of progesterone biosynthetic process [GO:2000184]; positive regulation of vasculogenesis [GO:2001214]; receptor internalization [GO:0031623]; regulation of systemic arterial blood pressure [GO:0003073]; regulation of the force of heart contraction [GO:0002026]; regulation of urine volume [GO:0035809]; response to glucocorticoid [GO:0051384]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to lipopolysaccharide [GO:0032496]; response to starvation [GO:0042594]; signal transduction [GO:0007165]; spongiotrophoblast layer development [GO:0060712]; vascular associated smooth muscle cell development [GO:0097084]; vasculogenesis [GO:0001570] | cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615] | adrenomedullin receptor binding [GO:0031700]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102] | 7766.87125137719 | 0.36642593824179 | 0.402810749932208 | 0.756739293473438 |
| P29558 | P29558 | RBMS1_HUMAN | RNA-binding motif, single-stranded-interacting protein 1 (Single-stranded DNA-binding protein MSSP-1) (Suppressor of CDC2 with RNA-binding motif 2) | RBMS1 | DNA replication [GO:0006260]; RNA processing [GO:0006396] | cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] | double-stranded DNA binding [GO:0003690]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697] | 15364.050608223999 | 0.185473105526627 | 0.402803026113982 | 0.756739293473438 |
| P61812 | P61812 | TGFB2_HUMAN | Transforming growth factor beta-2 proprotein (Cetermin) (Glioblastoma-derived T-cell suppressor factor) (G-TSF) [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-2 (TGF-beta-2)] | TGFB2 | activation of protein kinase activity [GO:0032147]; ascending aorta morphogenesis [GO:0035910]; atrial septum morphogenesis [GO:0060413]; atrial septum primum morphogenesis [GO:0003289]; atrioventricular valve morphogenesis [GO:0003181]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac muscle cell proliferation [GO:0060038]; cardiac right ventricle morphogenesis [GO:0003215]; cardioblast differentiation [GO:0010002]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell junction organization [GO:0045216]; collagen fibril organization [GO:0030199]; cranial skeletal system development [GO:1904888]; dopamine biosynthetic process [GO:0042416]; embryo development ending in birth or egg hatching [GO:0009792]; embryonic digestive tract development [GO:0048566]; embryonic limb morphogenesis [GO:0030326]; endocardial cushion fusion [GO:0003274]; endocardial cushion morphogenesis [GO:0003203]; epithelial cell differentiation [GO:0030855]; epithelial to mesenchymal transition [GO:0001837]; extrinsic apoptotic signaling pathway [GO:0097191]; eye development [GO:0001654]; generation of neurons [GO:0048699]; glial cell migration [GO:0008347]; hair follicle development [GO:0001942]; hair follicle morphogenesis [GO:0031069]; heart development [GO:0007507]; heart morphogenesis [GO:0003007]; heart valve morphogenesis [GO:0003179]; hemopoiesis [GO:0030097]; inner ear development [GO:0048839]; kidney development [GO:0001822]; male gonad development [GO:0008584]; membranous septum morphogenesis [GO:0003149]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905006]; negative regulation of gene expression [GO:0010629]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of Ras protein signal transduction [GO:0046580]; neural retina development [GO:0003407]; neural tube closure [GO:0001843]; neuron development [GO:0048666]; neutrophil chemotaxis [GO:0030593]; odontogenesis [GO:0042476]; outflow tract septum morphogenesis [GO:0003148]; pharyngeal arch artery morphogenesis [GO:0061626]; positive regulation of cardioblast differentiation [GO:0051891]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell division [GO:0051781]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905007]; positive regulation of heart contraction [GO:0045823]; positive regulation of immune response [GO:0050778]; positive regulation of integrin biosynthetic process [GO:0045726]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein secretion [GO:0050714]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of stress-activated MAPK cascade [GO:0032874]; positive regulation of timing of catagen [GO:0051795]; pulmonary valve morphogenesis [GO:0003184]; regulation of apoptotic process involved in outflow tract morphogenesis [GO:1902256]; regulation of cell population proliferation [GO:0042127]; regulation of timing of catagen [GO:0051794]; regulation of transforming growth factor beta2 production [GO:0032909]; response to hypoxia [GO:0001666]; response to progesterone [GO:0032570]; response to wounding [GO:0009611]; salivary gland morphogenesis [GO:0007435]; secondary palate development [GO:0062009]; signaling [GO:0023052]; skeletal system development [GO:0001501]; somatic stem cell division [GO:0048103]; substantia propria of cornea development [GO:1903701]; transforming growth factor beta receptor signaling pathway [GO:0007179]; uterine wall breakdown [GO:0042704]; uterus development [GO:0060065]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]; wound healing [GO:0042060] | axon [GO:0030424]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; platelet alpha granule lumen [GO:0031093] | amyloid-beta binding [GO:0001540]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; transforming growth factor beta receptor binding [GO:0005160]; type II transforming growth factor beta receptor binding [GO:0005114]; type III transforming growth factor beta receptor binding [GO:0034714] | 11694.781727320351 | 0.189566653309293 | 0.403165517655953 | 0.756903851238778 |
| Q9Y3A6 | Q9Y3A6 | TMED5_HUMAN | Transmembrane emp24 domain-containing protein 5 (p24 family protein gamma-2) (p24gamma2) (p28) | TMED5 | endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi ribbon formation [GO:0090161]; intracellular protein transport [GO:0006886] | cis-Golgi network [GO:0005801]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794] | cargo receptor activity [GO:0038024] | 119565.66895136051 | 0.187496092154973 | 0.403129260835792 | 0.756903851238778 |
| Q9BTE3 | Q9BTE3 | MCMBP_HUMAN | Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein) | MCMBP | cell division [GO:0051301]; DNA-templated DNA replication [GO:0006261]; sister chromatid cohesion [GO:0007062] | cell junction [GO:0030054]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | chromatin binding [GO:0003682] | 12545.57909559135 | -0.310471778485429 | 0.403496221574755 | 0.757273796436754 |
| Q99547 | Q99547 | MPH6_HUMAN | M-phase phosphoprotein 6 | MPHOSPH6 | maturation of 5.8S rRNA [GO:0000460] | cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | RNA binding [GO:0003723] | 5648.888145424595 | 0.620554345486743 | 0.403889323313971 | 0.757760564866544 |
| Q9BTD8 | Q9BTD8 | RBM42_HUMAN | RNA-binding protein 42 (RNA-binding motif protein 42) | RBM42 | mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025] | cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U4/U6 x U5 tri-snRNP complex [GO:0046540] | mRNA binding [GO:0003729]; RNA binding [GO:0003723] | 14136.085056921449 | 0.174773112804723 | 0.404405323389439 | 0.758477511527495 |
| Q7Z5R6 | Q7Z5R6 | AB1IP_HUMAN | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Rap1-GTP-interacting adapter molecule) (RIAM) (Retinoic acid-responsive proline-rich protein 1) (RARP-1) | APBB1IP | positive regulation of cell adhesion [GO:0045785]; signal transduction [GO:0007165]; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:0002291] | cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101] | 11021.601460381 | -0.125809636906091 | 0.405183411935999 | 0.759372088857053 | |
| Q9H479 | Q9H479 | FN3K_HUMAN | Fructosamine-3-kinase (EC 2.7.1.171) (Protein-psicosamine 3-kinase FN3K) (Protein-ribulosamine 3-kinase FN3K) (EC 2.7.1.172) | FN3K | epithelial cell differentiation [GO:0030855]; fructosamine metabolic process [GO:0030389]; fructoselysine metabolic process [GO:0030393]; phosphorylation [GO:0016310]; post-translational protein modification [GO:0043687]; protein deglycation [GO:0036525] | cytosol [GO:0005829] | ATP binding [GO:0005524]; kinase activity [GO:0016301]; protein-fructosamine 3-kinase activity [GO:0102194]; protein-ribulosamine 3-kinase activity [GO:0102193] | 8866.85269396125 | -0.179048531569235 | 0.405284362284456 | 0.759372088857053 |
| P46379 | P46379 | BAG6_HUMAN | Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe) | BAG6 | apoptotic process [GO:0006915]; brain development [GO:0007420]; cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; endoplasmic reticulum stress-induced pre-emptive quality control [GO:0061857]; ERAD pathway [GO:0036503]; immune response-activating cell surface receptor signaling pathway [GO:0002429]; internal peptidyl-lysine acetylation [GO:0018393]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; kidney development [GO:0001822]; lung development [GO:0030324]; maintenance of unfolded protein [GO:0036506]; natural killer cell activation [GO:0030101]; negative regulation of apoptotic process [GO:0043066]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of proteolysis [GO:0045861]; positive regulation of ERAD pathway [GO:1904294]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein stabilization [GO:0050821]; regulation of embryonic development [GO:0045995]; regulation of protein stability [GO:0031647]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]; ubiquitin-dependent protein catabolic process [GO:0006511] | BAT3 complex [GO:0071818]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; misfolded protein binding [GO:0051787]; molecular adaptor activity [GO:0060090]; molecular function activator activity [GO:0140677]; polyubiquitin modification-dependent protein binding [GO:0031593]; proteasome binding [GO:0070628]; ribosome binding [GO:0043022]; signaling receptor binding [GO:0005102]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-specific protease binding [GO:1990381] | 26114.7318847479 | 0.0496193545436146 | 0.405419858296243 | 0.759374848630252 |
| Q9Y4E1 | Q9Y4E1 | WAC2C_HUMAN | WASH complex subunit 2C (Vaccinia virus penetration factor) (VPEF) | WASHC2C | endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; negative regulation of barbed-end actin filament capping [GO:2000813]; protein localization to endosome [GO:0036010]; protein transport [GO:0015031]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; retrograde transport, endosome to Golgi [GO:0042147] | cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; WASH complex [GO:0071203] | phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; retromer complex binding [GO:1905394] | 5622.445124592845 | 0.115835565684981 | 0.405579659964351 | 0.759423117434902 |
| Q9H2U1 | Q9H2U1 | DHX36_HUMAN | ATP-dependent DNA/RNA helicase DHX36 (EC 3.6.4.12) (EC 3.6.4.13) (DEAD/H box polypeptide 36) (DEAH-box protein 36) (G4-resolvase-1) (G4R1) (MLE-like protein 1) (RNA helicase associated with AU-rich element protein) | DHX36 | 3'-UTR-mediated mRNA destabilization [GO:0061158]; cell differentiation [GO:0030154]; cellular response to arsenite ion [GO:1903843]; cellular response to heat [GO:0034605]; cellular response to UV [GO:0034644]; defense response to virus [GO:0051607]; G-quadruplex DNA unwinding [GO:0044806]; innate immune response [GO:0045087]; negative regulation of translation [GO:0017148]; ossification [GO:0001503]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cardioblast differentiation [GO:0051891]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of gene expression [GO:0010628]; positive regulation of hematopoietic progenitor cell differentiation [GO:1901534]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of intracellular mRNA localization [GO:1904582]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of telomere maintenance via telomere lengthening [GO:1904358]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of embryonic development [GO:0045995]; regulation of mRNA stability [GO:0043488]; regulation of transcription by RNA polymerase III [GO:0006359]; response to exogenous dsRNA [GO:0043330]; RNA secondary structure unwinding [GO:0010501]; spermatogenesis [GO:0007283]; telomerase RNA stabilization [GO:0090669] | axon [GO:0030424]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA helicase activity [GO:0003678]; double-stranded RNA binding [GO:0003725]; G-quadruplex DNA binding [GO:0051880]; G-quadruplex RNA binding [GO:0002151]; histone deacetylase binding [GO:0042826]; magnesium ion binding [GO:0000287]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; pre-miRNA binding [GO:0070883]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; single-stranded DNA binding [GO:0003697]; telomerase RNA binding [GO:0070034]; transcription cis-regulatory region binding [GO:0000976] | 6053.195847335595 | -0.26730570180995 | 0.406039851634 | 0.759782628585946 |
| P21926 | P21926 | CD9_HUMAN | CD9 antigen (5H9 antigen) (Cell growth-inhibiting gene 2 protein) (Leukocyte antigen MIC3) (Motility-related protein) (MRP-1) (Tetraspanin-29) (Tspan-29) (p24) (CD antigen CD9) | CD9 | cell adhesion [GO:0007155]; cell population proliferation [GO:0008283]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; glial cell migration [GO:0008347]; myoblast fusion involved in skeletal muscle regeneration [GO:0014905]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of platelet aggregation [GO:0090331]; paranodal junction assembly [GO:0030913]; platelet activation [GO:0030168]; receptor internalization [GO:0031623]; regulation of macrophage migration [GO:1905521]; sperm-egg recognition [GO:0035036] | clathrin-coated endocytic vesicle membrane [GO:0030669]; endocytic vesicle membrane [GO:0030666]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; protein-containing complex [GO:0032991] | integrin binding [GO:0005178] | 16711.64995127365 | -0.224731334589845 | 0.407529332770079 | 0.76181497838181 |
| Q9GZS3 | Q9GZS3 | SKI8_HUMAN | Superkiller complex protein 8 (Ski8) (Meiotic recombination REC14 protein homolog) (WD repeat-containing protein 61) [Cleaved into: Superkiller complex protein 8, N-terminally processed (WD repeat-containing protein 61, N-terminally processed)] | SKIC8 | negative regulation of myeloid cell differentiation [GO:0045638]; nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [GO:0070478]; rescue of stalled ribosome [GO:0072344]; transcription elongation by RNA polymerase II [GO:0006368]; Wnt signaling pathway [GO:0016055] | Cdc73/Paf1 complex [GO:0016593]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Ski complex [GO:0055087] | 24001.0952019401 | 0.189029821862761 | 0.407423617957629 | 0.76181497838181 | |
| P85037 | P85037 | FOXK1_HUMAN | Forkhead box protein K1 (Myocyte nuclear factor) (MNF) | FOXK1 | canonical glycolysis [GO:0061621]; cell differentiation [GO:0030154]; intracellular glucose homeostasis [GO:0001678]; muscle organ development [GO:0007517]; negative regulation of autophagy [GO:0010507]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of glucose metabolic process [GO:0010906]; regulation of transcription by RNA polymerase II [GO:0006357]; response to starvation [GO:0042594] | chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | 14-3-3 protein binding [GO:0071889]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976] | 8212.883177431815 | -0.160210588968548 | 0.40791329286025 | 0.762281239230269 |
| Q9Y576 | Q9Y576 | ASB1_HUMAN | Ankyrin repeat and SOCS box protein 1 (ASB-1) | ASB1 | intracellular signal transduction [GO:0035556]; male genitalia development [GO:0030539]; negative regulation of cytokine production [GO:0001818]; protein ubiquitination [GO:0016567] | cytosol [GO:0005829]; ubiquitin ligase complex [GO:0000151] | 6074.890354506135 | 0.199224571391741 | 0.408442462958921 | 0.762470568443628 | |
| Q9Y2H6 | Q9Y2H6 | FND3A_HUMAN | Fibronectin type-III domain-containing protein 3A (Human gene expressed in odontoblasts) | FNDC3A | cell-cell adhesion [GO:0098609]; fertilization [GO:0009566]; Sertoli cell development [GO:0060009]; spermatid development [GO:0007286] | acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; vesicle membrane [GO:0012506] | RNA binding [GO:0003723] | 11437.861263779549 | -0.180868965891554 | 0.408400367296923 | 0.762470568443628 |
| Q969S9 | Q969S9 | RRF2M_HUMAN | Ribosome-releasing factor 2, mitochondrial (RRF2mt) (EC 3.6.5.-) (Elongation factor G 2, mitochondrial) (EF-G2mt) (mEF-G 2) (Elongation factor G2) (hEFG2) | GFM2 | mitochondrial translation [GO:0032543]; mitochondrial translational termination [GO:0070126]; ribosome disassembly [GO:0032790] | cytosol [GO:0005829]; mitochondrial matrix [GO:0005759] | GTP binding [GO:0005525]; GTPase activity [GO:0003924] | 12425.866216572249 | -0.222203303818334 | 0.408492558539368 | 0.762470568443628 |
| P57764 | P57764 | GSDMD_HUMAN | Gasdermin-D (Gasdermin domain-containing protein 1) [Cleaved into: Gasdermin-D, N-terminal (GSDMD-NT) (hGSDMD-NTD); Gasdermin-D, C-terminal (GSDMD-CT) (hGSDMD-CTD); Gasdermin-D, p13 (Gasdermin-D, 13 kDa) (13 kDa GSDMD); Gasdermin-D, p40] | GSDMD | cellular response to extracellular stimulus [GO:0031668]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; pore complex assembly [GO:0046931]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; protein homooligomerization [GO:0051260]; protein secretion [GO:0009306]; pyroptosis [GO:0070269] | cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; NLRP3 inflammasome complex [GO:0072559]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] | cardiolipin binding [GO:1901612]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylserine binding [GO:0001786]; wide pore channel activity [GO:0022829] | 6962.569645615335 | 0.575697517337326 | 0.408552884891432 | 0.762470568443628 |
| P09429 | P09429 | HMGB1_HUMAN | High mobility group protein B1 (High mobility group protein 1) (HMG-1) | HMGB1 | activation of innate immune response [GO:0002218]; apoptotic cell clearance [GO:0043277]; autophagy [GO:0006914]; cellular response to lipopolysaccharide [GO:0071222]; dendritic cell chemotaxis [GO:0002407]; DNA geometric change [GO:0032392]; DNA recombination [GO:0006310]; DNA topological change [GO:0006265]; double-strand break repair via nonhomologous end joining [GO:0006303]; heterochromatin formation [GO:0031507]; inflammatory response [GO:0006954]; inflammatory response to antigenic stimulus [GO:0002437]; innate immune response [GO:0045087]; myeloid dendritic cell activation [GO:0001773]; negative regulation of apoptotic cell clearance [GO:2000426]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043371]; negative regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0017055]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; neuron projection development [GO:0031175]; neutrophil clearance [GO:0097350]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dendritic cell differentiation [GO:2001200]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA ligation [GO:0051106]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mismatch repair [GO:0032425]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; positive regulation of viral entry into host cell [GO:0046598]; regulation of restriction endodeoxyribonuclease activity [GO:0032072]; regulation of T cell mediated immune response to tumor cell [GO:0002840]; regulation of tolerance induction [GO:0002643]; regulation of transcription by RNA polymerase II [GO:0006357]; T-helper 1 cell activation [GO:0035711]; T-helper 1 cell differentiation [GO:0045063]; V(D)J recombination [GO:0033151] | alphav-beta3 integrin-HMGB1 complex [GO:0035868]; cell surface [GO:0009986]; condensed chromosome [GO:0000793]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome [GO:0005768]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; transcription repressor complex [GO:0017053] | bubble DNA binding [GO:0000405]; C-X-C chemokine binding [GO:0019958]; chemoattractant activity [GO:0042056]; cytokine activity [GO:0005125]; damaged DNA binding [GO:0003684]; DNA binding, bending [GO:0008301]; DNA polymerase binding [GO:0070182]; DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; four-way junction DNA binding [GO:0000400]; integrin binding [GO:0005178]; lipopolysaccharide binding [GO:0001530]; lyase activity [GO:0016829]; phosphatidylserine binding [GO:0001786]; RAGE receptor binding [GO:0050786]; receptor ligand activity [GO:0048018]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; single-stranded DNA binding [GO:0003697]; supercoiled DNA binding [GO:0097100]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] | 112448.684119952 | 0.276707751740087 | 0.40940347828433 | 0.763303753852917 |
| P07339 | P07339 | CATD_HUMAN | Cathepsin D (EC 3.4.23.5) [Cleaved into: Cathepsin D light chain; Cathepsin D heavy chain] | CTSD | antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; autophagosome assembly [GO:0000045]; insulin catabolic process [GO:1901143]; insulin receptor recycling [GO:0038020]; lipoprotein catabolic process [GO:0042159]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; proteolysis [GO:0006508]; regulation of establishment of protein localization [GO:0070201] | collagen-containing extracellular matrix [GO:0062023]; endosome lumen [GO:0031904]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane raft [GO:0045121]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724] | aspartic-type endopeptidase activity [GO:0004190]; aspartic-type peptidase activity [GO:0070001]; cysteine-type endopeptidase activity [GO:0004197]; peptidase activity [GO:0008233] | 355206.139795535 | 0.161281060317372 | 0.409692019422386 | 0.763590454620802 |
| P17655 | P17655 | CAN2_HUMAN | Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain) | CAPN2 | behavioral response to pain [GO:0048266]; blastocyst development [GO:0001824]; cellular response to amino acid stimulus [GO:0071230]; cellular response to interferon-beta [GO:0035458]; cellular response to lipopolysaccharide [GO:0071222]; female pregnancy [GO:0007565]; myoblast fusion [GO:0007520]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of phosphatidylcholine biosynthetic process [GO:2001247]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of cytoskeleton organization [GO:0051493]; regulation of interleukin-6 production [GO:0032675]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612] | calpain complex [GO:0110158]; chromatin [GO:0000785]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143] | calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; cysteine-type peptidase activity [GO:0008234]; cytoskeletal protein binding [GO:0008092]; enzyme binding [GO:0019899]; protein-containing complex binding [GO:0044877] | 66802.4924045809 | -0.193523908809446 | 0.410699074712484 | 0.765215704479097 |
| Q9BPZ3 | Q9BPZ3 | PAIP2_HUMAN | Polyadenylate-binding protein-interacting protein 2 (PABP-interacting protein 2) (PAIP-2) (Poly(A)-binding protein-interacting protein 2) | PAIP2 | memory [GO:0007613]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; regulation of long-term synaptic potentiation [GO:1900271]; spermatogenesis [GO:0007283]; translation [GO:0006412] | cytoplasm [GO:0005737] | mRNA binding [GO:0003729]; mRNA regulatory element binding translation repressor activity [GO:0000900]; translation repressor activity [GO:0030371] | 5900.148515809426 | 0.253360374581138 | 0.41120245687433 | 0.765398528465819 |
| Q01081 | Q01081 | U2AF1_HUMAN | Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 small nuclear RNA auxiliary factor 1) (U2 snRNP auxiliary factor small subunit) | U2AF1 | mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380] | Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; U2AF complex [GO:0089701] | metal ion binding [GO:0046872]; pre-mRNA 3'-splice site binding [GO:0030628]; RNA binding [GO:0003723]; RS domain binding [GO:0050733] | 15424.54075684215 | 0.222463074546658 | 0.411473874478785 | 0.765400844647667 |
| Q92905 | Q92905 | CSN5_HUMAN | COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1) | COPS5 | exosomal secretion [GO:1990182]; negative regulation of apoptotic process [GO:0043066]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-translational protein modification [GO:0043687]; protein deneddylation [GO:0000338]; protein deubiquitination [GO:0016579]; protein neddylation [GO:0045116]; proteolysis [GO:0006508]; regulation of cell cycle [GO:0051726]; regulation of IRE1-mediated unfolded protein response [GO:1903894]; regulation of JNK cascade [GO:0046328]; regulation of protein neddylation [GO:2000434]; translation [GO:0006412] | chromatin [GO:0000785]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 3 complex [GO:0005852]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; synaptic vesicle [GO:0008021] | deNEDDylase activity [GO:0019784]; enzyme binding [GO:0019899]; macrophage migration inhibitory factor binding [GO:0035718]; metal ion binding [GO:0046872]; metal-dependent deubiquitinase activity [GO:0140492]; metallopeptidase activity [GO:0008237]; transcription coactivator activity [GO:0003713]; translation initiation factor activity [GO:0003743] | 22626.24664142605 | 0.0708637205426008 | 0.411916376476909 | 0.765947569712054 |
| Q96HR3 | Q96HR3 | MED30_HUMAN | Mediator of RNA polymerase II transcription subunit 30 (Mediator complex subunit 30) (TRAP/Mediator complex component TRAP25) (Thyroid hormone receptor-associated protein 6) (Thyroid hormone receptor-associated protein complex 25 kDa component) (Trap25) | MED30 | positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; RNA polymerase II preinitiation complex assembly [GO:0051123]; somatic stem cell population maintenance [GO:0035019] | core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] | nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; ubiquitin protein ligase activity [GO:0061630] | 6408.114015249024 | 0.383456259340665 | 0.412128903828658 | 0.765947569712054 |
| O43516 | O43516 | WIPF1_HUMAN | WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) | WIPF1 | actin filament-based movement [GO:0030048]; actin polymerization or depolymerization [GO:0008154]; protein-containing complex assembly [GO:0065003]; response to other organism [GO:0051707] | actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; ruffle [GO:0001726] | actin binding [GO:0003779]; profilin binding [GO:0005522]; protein folding chaperone [GO:0044183]; SH3 domain binding [GO:0017124] | 8755.17562859416 | 0.338208024578861 | 0.412173339225565 | 0.765947569712054 |
| Q5T2E6 | Q5T2E6 | ARMD3_HUMAN | Armadillo-like helical domain-containing protein 3 | ARMH3 | regulation of Golgi organization [GO:1903358] | cytosol [GO:0005829]; Golgi membrane [GO:0000139] | 5292.226593221525 | -0.154348623187686 | 0.412494175479467 | 0.765980219273383 | |
| Q5QJE6 | Q5QJE6 | TDIF2_HUMAN | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | DNTTIP2 | ribosomal small subunit biogenesis [GO:0042274]; RNA processing [GO:0006396] | chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] | RNA binding [GO:0003723] | 7822.7400298991 | 0.144782745482259 | 0.412394931232403 | 0.765980219273383 |
| Q8N2S1 | Q8N2S1 | LTBP4_HUMAN | Latent-transforming growth factor beta-binding protein 4 (LTBP-4) | LTBP4 | elastic fiber assembly [GO:0048251]; hormone secretion [GO:0046879]; protein folding [GO:0006457]; regulation of cell growth [GO:0001558]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; transforming growth factor beta receptor signaling pathway [GO:0007179] | collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; microfibril [GO:0001527] | calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; integrin binding [GO:0005178]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024] | 7639.959443361855 | -0.454697214664742 | 0.412596475330456 | 0.765980219273383 |
| Q9UHB6 | Q9UHB6 | LIMA1_HUMAN | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | LIMA1 | actin filament bundle assembly [GO:0051017]; cell migration [GO:0016477]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; intestinal cholesterol absorption [GO:0030299]; negative regulation of actin filament depolymerization [GO:0030835]; ruffle organization [GO:0031529] | actin cytoskeleton [GO:0015629]; brush border membrane [GO:0031526]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; stress fiber [GO:0001725] | actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; cadherin binding [GO:0045296]; metal ion binding [GO:0046872] | 55139.46600060205 | -0.201824974677058 | 0.413398691740893 | 0.767218141960007 |
| Q86WR0 | Q86WR0 | CCD25_HUMAN | Coiled-coil domain-containing protein 25 | CCDC25 | positive regulation of cell motility [GO:2000147] | endomembrane system [GO:0012505]; plasma membrane [GO:0005886] | DNA binding [GO:0003677] | 13634.693459289749 | 0.205602741945112 | 0.414865844111476 | 0.769688890876104 |
| P11021 | P11021 | BIP_HUMAN | Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein) | HSPA5 | cellular response to glucose starvation [GO:0042149]; cellular response to interleukin-4 [GO:0071353]; cerebellar Purkinje cell layer development [GO:0021680]; cerebellum structural organization [GO:0021589]; chaperone cofactor-dependent protein refolding [GO:0051085]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER overload response [GO:0006983]; ERAD pathway [GO:0036503]; maintenance of protein localization in endoplasmic reticulum [GO:0035437]; negative regulation of apoptotic process [GO:0043066]; negative regulation of IRE1-mediated unfolded protein response [GO:1903895]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of cell migration [GO:0030335]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-translational protein targeting to membrane, translocation [GO:0031204]; protein folding in endoplasmic reticulum [GO:0034975]; protein refolding [GO:0042026]; regulation of ATF6-mediated unfolded protein response [GO:1903891]; regulation of IRE1-mediated unfolded protein response [GO:1903894]; regulation of PERK-mediated unfolded protein response [GO:1903897]; regulation of protein folding in endoplasmic reticulum [GO:0060904]; response to endoplasmic reticulum stress [GO:0034976]; substantia nigra development [GO:0021762] | cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; misfolded protein binding [GO:0051787]; protein domain specific binding [GO:0019904]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; ribosome binding [GO:0043022]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082] | 467002.3418834385 | 0.10258099626159 | 0.416083396919018 | 0.771130168378753 |
| Q53F19 | Q53F19 | NCBP3_HUMAN | Nuclear cap-binding protein subunit 3 (Protein ELG) | NCBP3 | 7-methylguanosine mRNA capping [GO:0006370]; defense response to virus [GO:0051607]; mRNA export from nucleus [GO:0006406]; mRNA transcription by RNA polymerase II [GO:0042789]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; snRNA export from nucleus [GO:0006408] | cytoplasm [GO:0005737]; nuclear cap binding complex [GO:0005846]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; RNA cap binding complex [GO:0034518] | mRNA binding [GO:0003729]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339] | 11413.0813039568 | 0.11971749006007 | 0.416187090522807 | 0.771130168378753 |
| P52948 | P52948 | NUP98_HUMAN | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | NUP98 | mRNA transport [GO:0051028]; nuclear pore complex assembly [GO:0051292]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000973]; protein import into nucleus [GO:0006606]; proteolysis [GO:0006508]; RNA export from nucleus [GO:0006405]; telomere tethering at nuclear periphery [GO:0034398] | cytosol [GO:0005829]; nuclear body [GO:0016604]; nuclear envelope [GO:0005635]; nuclear inclusion body [GO:0042405]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore cytoplasmic filaments [GO:0044614]; nuclear pore nuclear basket [GO:0044615]; nuclear pore outer ring [GO:0031080]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904] | molecular condensate scaffold activity [GO:0140693]; mRNA binding [GO:0003729]; nuclear localization sequence binding [GO:0008139]; promoter-specific chromatin binding [GO:1990841]; RNA binding [GO:0003723]; serine-type peptidase activity [GO:0008236]; structural constituent of nuclear pore [GO:0017056]; transcription coactivator activity [GO:0003713] | 12725.85355046895 | -0.226059846128832 | 0.416044600360242 | 0.771130168378753 |
| Q5T1M5 | Q5T1M5 | FKB15_HUMAN | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | FKBP15 | endocytosis [GO:0006897] | actin cytoskeleton [GO:0015629]; early endosome [GO:0005769]; growth cone [GO:0030426]; membrane [GO:0016020] | actin binding [GO:0003779]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755] | 12307.7660802709 | -0.128530369181443 | 0.417171655547284 | 0.771944676789977 |
| P83881;Q969Q0 | P83881 | RL36A_HUMAN | Large ribosomal subunit protein eL42 (60S ribosomal protein L36a) (60S ribosomal protein L44) (Cell growth-inhibiting gene 15 protein) (Cell migration-inducing gene 6 protein) | RPL36A | cytoplasmic translation [GO:0002181]; translation [GO:0006412] | cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; ribosome [GO:0005840] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 103998.237780494 | 0.141652215401233 | 0.417060311333275 | 0.771944676789977 |
| Q8NCH0 | Q8NCH0 | CHSTE_HUMAN | Carbohydrate sulfotransferase 14 (EC 2.8.2.35) (Dermatan 4-sulfotransferase 1) (D4ST-1) (hD4ST1) | CHST14 | carbohydrate biosynthetic process [GO:0016051]; dermatan sulfate biosynthetic process [GO:0030208]; dermatan sulfate proteoglycan metabolic process [GO:0050655] | extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020] | N-acetylgalactosamine 4-O-sulfotransferase activity [GO:0001537]; phosphate ion binding [GO:0042301]; sulfotransferase activity [GO:0008146] | 15002.627785608849 | -0.181514659538304 | 0.417497869780362 | 0.772296092123907 |
| Q96JY6 | Q96JY6 | PDLI2_HUMAN | PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) | PDLIM2 | actin cytoskeleton organization [GO:0030036]; heart development [GO:0007507]; muscle structure development [GO:0061061]; protein catabolic process [GO:0030163] | adherens junction [GO:0005912]; cortical actin cytoskeleton [GO:0030864]; filamentous actin [GO:0031941]; nucleus [GO:0005634]; stress fiber [GO:0001725]; Z disc [GO:0030018] | actin binding [GO:0003779]; filamin binding [GO:0031005]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; myosin heavy chain binding [GO:0032036]; ubiquitin protein ligase binding [GO:0031625] | 344255.653188589 | -0.174407778099769 | 0.418201364500223 | 0.773344951455047 |
| Q5SW96 | Q5SW96 | ARH_HUMAN | Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein) | LDLRAP1 | amyloid precursor protein metabolic process [GO:0042982]; cellular response to cytokine stimulus [GO:0071345]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; low-density lipoprotein particle clearance [GO:0034383]; positive regulation of cholesterol metabolic process [GO:0090205]; positive regulation of low-density lipoprotein particle clearance [GO:1905581]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of receptor-mediated endocytosis involved in cholesterol transport [GO:1905602]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; receptor-mediated endocytosis involved in cholesterol transport [GO:0090118]; regulation of protein binding [GO:0043393]; regulation of protein localization to plasma membrane [GO:1903076] | axon [GO:0030424]; basal plasma membrane [GO:0009925]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; early endosome [GO:0005769]; neurofilament [GO:0005883]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] | amyloid-beta binding [GO:0001540]; AP-1 adaptor complex binding [GO:0035650]; AP-2 adaptor complex binding [GO:0035612]; clathrin adaptor activity [GO:0035615]; clathrin binding [GO:0030276]; low-density lipoprotein particle receptor binding [GO:0050750]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphotyrosine residue binding [GO:0001784]; signaling adaptor activity [GO:0035591]; signaling receptor complex adaptor activity [GO:0030159] | 5412.27681453293 | -0.186169456164724 | 0.418716542154891 | 0.774045000929726 |
| P16104;Q96QV6 | P16104 | H2AX_HUMAN | Histone H2AX (H2a/x) (Histone H2A.X) | H2AX | cellular response to gamma radiation [GO:0071480]; cellular senescence [GO:0090398]; cerebral cortex development [GO:0021987]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; heterochromatin organization [GO:0070828]; meiotic cell cycle [GO:0051321]; nucleosome assembly [GO:0006334]; positive regulation of DNA repair [GO:0045739]; response to ionizing radiation [GO:0010212]; spermatogenesis [GO:0007283] | centrosome [GO:0005813]; condensed nuclear chromosome [GO:0000794]; extracellular exosome [GO:0070062]; male germ cell nucleus [GO:0001673]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; replication fork [GO:0005657]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]; XY body [GO:0001741] | damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; nucleosomal DNA binding [GO:0031492]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] | 47548.996599705846 | 0.202877329668755 | 0.419311265765417 | 0.77489159550778 |
| Q6IA69 | Q6IA69 | NADE_HUMAN | Glutamine-dependent NAD(+) synthetase (EC 6.3.5.1) (NAD(+) synthase [glutamine-hydrolyzing]) (NAD(+) synthetase) | NADSYN1 | 'de novo' NAD biosynthetic process [GO:0034627]; NAD biosynthetic process [GO:0009435] | cytoplasm [GO:0005737]; cytosol [GO:0005829] | ATP binding [GO:0005524]; glutaminase activity [GO:0004359]; NAD+ synthase (glutamine-hydrolyzing) activity [GO:0003952] | 12893.8343982458 | 0.115884067853595 | 0.42070749747057 | 0.776880838728059 |
| Q13586 | Q13586 | STIM1_HUMAN | Stromal interaction molecule 1 | STIM1 | activation of store-operated calcium channel activity [GO:0032237]; detection of calcium ion [GO:0005513]; enamel mineralization [GO:0070166]; intracellular calcium ion homeostasis [GO:0006874]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of angiogenesis [GO:0045766]; regulation of calcium ion transport [GO:0051924]; regulation of store-operated calcium entry [GO:2001256]; store-operated calcium entry [GO:0002115] | cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; microtubule [GO:0005874]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; sarcoplasmic reticulum membrane [GO:0033017] | calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; microtubule plus-end binding [GO:0051010]; protease binding [GO:0002020] | 21188.194903153402 | 0.23173064685906 | 0.420799028248573 | 0.776880838728059 |
| Q9BT88 | Q9BT88 | SYT11_HUMAN | Synaptotagmin-11 (Synaptotagmin XI) (SytXI) | SYT11 | autophagy [GO:0006914]; calcium ion regulated lysosome exocytosis [GO:1990927]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cellular response to calcium ion [GO:0071277]; establishment of vesicle localization [GO:0051650]; learning [GO:0007612]; memory [GO:0007613]; negative regulation of cytokine production [GO:0001818]; negative regulation of dopamine secretion [GO:0033602]; negative regulation of endocytosis [GO:0045806]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of neurotransmitter secretion [GO:0046929]; negative regulation of phagocytosis [GO:0050765]; negative regulation of tumor necrosis factor production [GO:0032720]; plasma membrane repair [GO:0001778]; positive regulation of protein localization to phagocytic vesicle [GO:1905171]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of defense response to bacterium [GO:1900424]; regulation of dopamine secretion [GO:0014059]; regulation of phagosome maturation [GO:1905162]; regulation of synaptic vesicle endocytosis [GO:1900242]; vesicle fusion [GO:0006906] | axon [GO:0030424]; clathrin-coated vesicle membrane [GO:0030665]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; dopaminergic synapse [GO:0098691]; early phagosome [GO:0032009]; excitatory synapse [GO:0060076]; exocytic vesicle [GO:0070382]; inhibitory synapse [GO:0060077]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; phagocytic cup [GO:0001891]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; presynaptic active zone membrane [GO:0048787]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802]; vesicle [GO:0031982] | beta-tubulin binding [GO:0048487]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; identical protein binding [GO:0042802]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149]; translation initiation factor binding [GO:0031369]; ubiquitin protein ligase binding [GO:0031625] | 11253.41714605615 | -0.72654703151574 | 0.4205355531714 | 0.776880838728059 |
| Q9GZY8 | Q9GZY8 | MFF_HUMAN | Mitochondrial fission factor | MFF | mitochondrial fission [GO:0000266]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial fusion [GO:0008053]; mitochondrion organization [GO:0007005]; peroxisome fission [GO:0016559]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; protein targeting to mitochondrion [GO:0006626]; regulation of mitochondrion organization [GO:0010821]; regulation of peroxisome organization [GO:1900063]; release of cytochrome c from mitochondria [GO:0001836] | mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; synaptic vesicle [GO:0008021] | identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] | 19197.815096231403 | 0.208365442635892 | 0.421657103342077 | 0.777958042180465 |
| Q96IG2 | Q96IG2 | FXL20_HUMAN | F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like) | FBXL20 | behavioral fear response [GO:0001662]; regulation of protein catabolic process at presynapse, modulating synaptic transmission [GO:0099575]; regulation of synaptic vesicle exocytosis [GO:2000300]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] | cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; presynapse [GO:0098793]; SCF ubiquitin ligase complex [GO:0019005]; Schaffer collateral - CA1 synapse [GO:0098685] | 6455.039076134715 | -0.258249159337083 | 0.422175992394203 | 0.778304045856802 | |
| Q9NRX2 | Q9NRX2 | RM17_HUMAN | Large ribosomal subunit protein bL17m (39S ribosomal protein L17, mitochondrial) (L17mt) (MRP-L17) (LYST-interacting protein 2) | MRPL17 | mitochondrial translation [GO:0032543] | cytosolic large ribosomal subunit [GO:0022625]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] | protein domain specific binding [GO:0019904]; structural constituent of ribosome [GO:0003735] | 16061.76942552645 | 0.211482706523918 | 0.422256730844301 | 0.778304045856802 |
| P19883 | P19883 | FST_HUMAN | Follistatin (FS) (Activin-binding protein) | FST | ameloblast differentiation [GO:0036305]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; female gonad development [GO:0008585]; gamete generation [GO:0007276]; hair follicle morphogenesis [GO:0031069]; hematopoietic progenitor cell differentiation [GO:0002244]; keratinocyte proliferation [GO:0043616]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis of dentin-containing tooth [GO:0042475]; pattern specification process [GO:0007389]; positive regulation of hair follicle development [GO:0051798]; regulation of BMP signaling pathway [GO:0030510]; response to organic cyclic compound [GO:0014070]; skeletal system development [GO:0001501] | cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634] | activin binding [GO:0048185]; activin receptor antagonist activity [GO:0038102]; heparan sulfate proteoglycan binding [GO:0043395] | 39589.3000445004 | 0.184538404489243 | 0.42342199833681 | 0.78019806262646 |
| Q9NYU2 | Q9NYU2 | UGGG1_HUMAN | UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1) (hUGT1) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase) (UDP-glucose ceramide glucosyltransferase-like 1) | UGGT1 | 'de novo' post-translational protein folding [GO:0051084]; ERAD pathway [GO:0036503]; protein N-linked glycosylation via asparagine [GO:0018279] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; protein-containing complex [GO:0032991] | UDP-glucose:glycoprotein glucosyltransferase activity [GO:0003980]; unfolded protein binding [GO:0051082] | 47160.3010607979 | -0.0966988125391406 | 0.423913029933817 | 0.780595134093274 |
| Q96DH6 | Q96DH6 | MSI2H_HUMAN | RNA-binding protein Musashi homolog 2 (Musashi-2) | MSI2 | central nervous system development [GO:0007417]; regulation of translation [GO:0006417]; stem cell development [GO:0048864] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231] | identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723] | 9556.37139786361 | -0.108138389519297 | 0.425214108033319 | 0.78233306949616 |
| O75494 | O75494 | SRS10_HUMAN | Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein) | SRSF10 | cytosolic transport [GO:0016482]; mRNA splice site recognition [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; regulation of DNA-templated transcription [GO:0006355]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal tri-snRNP complex assembly [GO:0000244] | axon terminus [GO:0043679]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | RNA binding [GO:0003723]; RS domain binding [GO:0050733]; unfolded protein binding [GO:0051082] | 68784.9578806383 | 0.209087755226694 | 0.425214525198035 | 0.78233306949616 |
| Q96HW7 | Q96HW7 | INT4_HUMAN | Integrator complex subunit 4 (Int4) | INTS4 | intercellular transport [GO:0010496]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; snRNA processing [GO:0016180] | endosome [GO:0005768]; integrator complex [GO:0032039]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | 605.7791544347269 | -1.63461130773428 | 0.426461624704031 | 0.784014135487683 | |
| Q9P287 | Q9P287 | BCCIP_HUMAN | BRCA2 and CDKN1A-interacting protein (P21- and CDK-associated protein 1) (Protein TOK-1) | BCCIP | DNA repair [GO:0006281]; establishment of mitotic spindle orientation [GO:0000132]; microtubule anchoring [GO:0034453]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; neuroendocrine cell differentiation [GO:0061101]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079] | centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; mitotic spindle pole [GO:0097431]; nuclear cyclin-dependent protein kinase holoenzyme complex [GO:0019908]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | kinase regulator activity [GO:0019207]; RNA binding [GO:0003723]; tubulin binding [GO:0015631] | 11061.53229525415 | 0.151144194551958 | 0.427425185105385 | 0.785275972375847 |
| Q92734 | Q92734 | TFG_HUMAN | Protein TFG (TRK-fused gene protein) | TFG | COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; intracellular membrane-bounded organelle [GO:0043231] | identical protein binding [GO:0042802] | 60209.96267790155 | 0.193560883890756 | 0.427372856649967 | 0.785275972375847 |
| Q969Z0 | Q969Z0 | FAKD4_HUMAN | FAST kinase domain-containing protein 4 (Cell cycle progression restoration protein 2) (Cell cycle progression protein 2) (Protein TBRG4) (Transforming growth factor beta regulator 4) | TBRG4 | mitochondrial mRNA processing [GO:0090615]; mitochondrial RNA processing [GO:0000963]; mRNA metabolic process [GO:0016071]; positive regulation of cell population proliferation [GO:0008284]; regulation of cell cycle [GO:0051726]; regulation of mitochondrial mRNA stability [GO:0044528] | mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770] | RNA binding [GO:0003723] | 6231.407401219176 | -0.194518159973678 | 0.427640365376175 | 0.785416632162531 |
| Q15121 | Q15121 | PEA15_HUMAN | Astrocytic phosphoprotein PEA-15 (15 kDa phosphoprotein enriched in astrocytes) (Phosphoprotein enriched in diabetes) (PED) | PEA15 | apoptotic process [GO:0006915]; MAPK cascade [GO:0000165]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of glucose import [GO:0046325]; organic substance transport [GO:0071702]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043] | cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; microtubule associated complex [GO:0005875]; nucleoplasm [GO:0005654] | 450204.414416068 | -0.130950301617219 | 0.428322268091001 | 0.786414118925344 | |
| P46736 | P46736 | BRCC3_HUMAN | Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36) | BRCC3 | cell division [GO:0051301]; cellular response to ionizing radiation [GO:0071479]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; positive regulation of DNA repair [GO:0045739]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; protein K63-linked deubiquitination [GO:0070536]; proteolysis [GO:0006508]; regulation of DNA damage checkpoint [GO:2000001]; regulation of DNA repair [GO:0006282]; response to ionizing radiation [GO:0010212]; response to X-ray [GO:0010165] | BRCA1-A complex [GO:0070531]; BRISC complex [GO:0070552]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear ubiquitin ligase complex [GO:0000152]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]; ubiquitin ligase complex [GO:0000151] | cysteine-type deubiquitinase activity [GO:0004843]; enzyme regulator activity [GO:0030234]; K63-linked deubiquitinase activity [GO:0061578]; metal ion binding [GO:0046872]; metal-dependent deubiquitinase activity [GO:0140492]; metallopeptidase activity [GO:0008237]; polyubiquitin modification-dependent protein binding [GO:0031593] | 6422.32601561611 | 0.235559156696577 | 0.429789962230001 | 0.787927720593071 |
| O76071 | O76071 | CIAO1_HUMAN | Probable cytosolic iron-sulfur protein assembly protein CIAO1 (WD repeat-containing protein 39) | CIAO1 | chromosome segregation [GO:0007059]; iron-sulfur cluster assembly [GO:0016226]; positive regulation of cell population proliferation [GO:0008284]; protein maturation by iron-sulfur cluster transfer [GO:0097428]; regulation of transcription by RNA polymerase II [GO:0006357] | CIA complex [GO:0097361]; cytoplasm [GO:0005737]; MMXD complex [GO:0071817] | 23640.4054966698 | 0.208227028381978 | 0.429504799680446 | 0.787927720593071 | |
| O60504 | O60504 | VINEX_HUMAN | Vinexin (SH3-containing adapter molecule 1) (SCAM-1) (Sorbin and SH3 domain-containing protein 3) | SORBS3 | cell adhesion [GO:0007155]; cell-substrate adhesion [GO:0031589]; MAPK cascade [GO:0000165]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cytoskeleton organization [GO:0051495]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of stress fiber assembly [GO:0051496] | cell-substrate junction [GO:0030055]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634] | structural constituent of cytoskeleton [GO:0005200]; vinculin binding [GO:0017166] | 26464.65786250005 | -0.0665593327570184 | 0.42984196688196 | 0.787927720593071 |
| O75027 | O75027 | ABCB7_HUMAN | Iron-sulfur clusters transporter ABCB7, mitochondrial (ATP-binding cassette sub-family B member 7, mitochondrial) (ATP-binding cassette transporter 7) (ABC transporter 7 protein) | ABCB7 | intracellular iron ion homeostasis [GO:0006879]; iron ion transmembrane transport [GO:0034755]; iron-sulfur cluster assembly [GO:0016226]; iron-sulfur cluster export from the mitochondrion [GO:0140466]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; positive regulation of heme biosynthetic process [GO:0070455]; positive regulation of iron-sulfur cluster assembly [GO:1903331]; transmembrane transport [GO:0055085] | mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] | ABC-type iron-sulfur cluster transporter activity [GO:0140481]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; heme transmembrane transporter activity [GO:0015232]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] | 6194.256163615245 | -0.204947193679461 | 0.431726549318569 | 0.790724634669232 |
| Q9Y5S9 | Q9Y5S9 | RBM8A_HUMAN | RNA-binding protein 8A (Binder of OVCA1-1) (BOV-1) (RNA-binding motif protein 8A) (RNA-binding protein Y14) (Ribonucleoprotein RBM8A) | RBM8A | mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA processing [GO:0050684]; regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000622]; regulation of translation [GO:0006417]; RNA splicing [GO:0008380] | catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; exon-exon junction complex [GO:0035145]; exon-exon junction subcomplex mago-y14 [GO:1990501]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 1 spliceosome [GO:0071006] | mRNA binding [GO:0003729]; RNA binding [GO:0003723] | 25974.25388722265 | 0.227880255566979 | 0.431631178128953 | 0.790724634669232 |
| P49207 | P49207 | RL34_HUMAN | Large ribosomal subunit protein eL34 (60S ribosomal protein L34) | RPL34 | cytoplasmic translation [GO:0002181]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; synapse [GO:0045202] | cadherin binding [GO:0045296]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 126331.271964735 | 0.175830279221669 | 0.431786448935158 | 0.790724634669232 |
| Q92844 | Q92844 | TANK_HUMAN | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | TANK | canonical NF-kappaB signal transduction [GO:0007249]; cellular response to interleukin-1 [GO:0071347]; cellular response to ionizing radiation [GO:0071479]; cellular response to tumor necrosis factor [GO:0071356]; defense response to virus [GO:0051607]; DNA damage response [GO:0006974]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of protein deubiquitination [GO:1903003]; positive regulation of type I interferon production [GO:0032481]; positive regulation of ubiquitin-specific protease activity [GO:2000158]; signal transduction [GO:0007165]; type I interferon-mediated signaling pathway [GO:0060337] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991]; serine/threonine protein kinase complex [GO:1902554] | deubiquitinase activator activity [GO:0035800]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; molecular function inhibitor activity [GO:0140678]; ubiquitin protein ligase binding [GO:0031625] | 19561.67877698375 | 0.360884465138378 | 0.431995694967333 | 0.79085221573018 |
| P20337 | P20337 | RAB3B_HUMAN | Ras-related protein Rab-3B | RAB3B | antigen processing and presentation [GO:0019882]; positive regulation of dopamine uptake involved in synaptic transmission [GO:0051586]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; regulation of exocytosis [GO:0017157]; regulation of synaptic vesicle cycle [GO:0098693]; regulation of vesicle size [GO:0097494]; vesicle docking involved in exocytosis [GO:0006904] | cytoplasm [GO:0005737]; dopaminergic synapse [GO:0098691]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; vesicle [GO:0031982] | GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489] | 43801.0900149723 | 0.102914331723762 | 0.432860904663435 | 0.792180195679271 |
| Q9BYM8 | Q9BYM8 | HOIL1_HUMAN | RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.31) (HBV-associated factor 4) (Heme-oxidized IRP2 ubiquitin ligase 1) (HOIL-1) (Hepatitis B virus X-associated protein 4) (RING finger protein 54) (RING-type E3 ubiquitin transferase HOIL-1) (Ubiquitin-conjugating enzyme 7-interacting protein 3) | RBCK1 | cytoplasmic sequestering of protein [GO:0051220]; defense response to bacterium [GO:0042742]; negative regulation of necroptotic process [GO:0060546]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein linear polyubiquitination [GO:0097039]; protein polyubiquitination [GO:0000209]; T cell receptor signaling pathway [GO:0050852] | cytosol [GO:0005829]; LUBAC complex [GO:0071797] | identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein sequestering activity [GO:0140311]; transcription coactivator activity [GO:0003713]; ubiquitin binding [GO:0043130]; ubiquitin ligase activator activity [GO:1990757]; ubiquitin-protein transferase activity [GO:0004842] | 11596.2972552727 | -0.0902726924459292 | 0.433349740472267 | 0.792562824246568 |
| P51571 | P51571 | SSRD_HUMAN | Translocon-associated protein subunit delta (TRAP-delta) (Signal sequence receptor subunit delta) (SSR-delta) | SSR4 | endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Sec61 translocon complex [GO:0005784] | 1126417.097156435 | -0.130130228195484 | 0.433281225993757 | 0.792562824246568 | ||
| Q8WYL5 | Q8WYL5 | SSH1_HUMAN | Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) | SSH1 | actin cytoskeleton organization [GO:0030036]; cell morphogenesis [GO:0000902]; cellular response to ATP [GO:0071318]; excitatory chemical synaptic transmission [GO:0098976]; negative regulation of actin filament polymerization [GO:0030837]; positive regulation of AMPA glutamate receptor clustering [GO:1904719]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; protein dephosphorylation [GO:0006470]; regulation of protein metabolic process [GO:0051246] | cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; midbody [GO:0030496]; plasma membrane [GO:0005886]; synapse [GO:0045202] | actin binding [GO:0003779]; myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138] | 6441.73917839688 | -0.276859459405067 | 0.433562086674194 | 0.792695315616645 |
| Q96FW1 | Q96FW1 | OTUB1_HUMAN | Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1) | OTUB1 | adaptive immune response [GO:0002250]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; negative regulation of double-strand break repair [GO:2000780]; positive regulation of TORC1 signaling [GO:1904263]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; proteolysis [GO:0006508] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654] | cysteine-type deubiquitinase activity [GO:0004843]; deNEDDylase activity [GO:0019784]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase inhibitor activity [GO:0055105] | 29842.7110025558 | 0.143804054598111 | 0.434711527721263 | 0.794028212788096 |
| Q12904 | Q12904 | AIMP1_HUMAN | Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (Multisynthase complex auxiliary component p43) [Cleaved into: Endothelial monocyte-activating polypeptide 2 (EMAP-2) (Endothelial monocyte-activating polypeptide II) (EMAP-II) (Small inducible cytokine subfamily E member 1)] | AIMP1 | angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell-cell signaling [GO:0007267]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; leukocyte migration [GO:0050900]; negative regulation of endothelial cell proliferation [GO:0001937]; positive regulation of glucagon secretion [GO:0070094]; translation [GO:0006412] | aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleus [GO:0005634] | cytokine activity [GO:0005125]; GTPase binding [GO:0051020]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049] | 58034.34073458785 | 0.143182277111394 | 0.435431313363754 | 0.795086632780867 |
| Q9BR76 | Q9BR76 | COR1B_HUMAN | Coronin-1B (Coronin-2) | CORO1B | actin cytoskeleton organization [GO:0030036]; actin filament branching [GO:0090135]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; cell migration [GO:0016477]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; endothelial cell chemotaxis [GO:0035767]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; negative regulation of smooth muscle cell chemotaxis [GO:0071672]; positive regulation of lamellipodium morphogenesis [GO:2000394]; protein localization to cell leading edge [GO:1902463]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; ruffle organization [GO:0031529]; wound healing [GO:0042060] | actin filament [GO:0005884]; cell leading edge [GO:0031252]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; stress fiber [GO:0001725] | actin filament binding [GO:0051015]; Arp2/3 complex binding [GO:0071933]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802] | 75319.26316399494 | 0.0750934311820067 | 0.436161145326535 | 0.795197129284149 |
| Q9NV31 | Q9NV31 | IMP3_HUMAN | U3 small nucleolar ribonucleoprotein protein IMP3 (U3 snoRNP protein IMP3) (BRMS2) | IMP3 | maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364] | Mpp10 complex [GO:0034457]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome [GO:0030684]; small ribosomal subunit [GO:0015935]; small-subunit processome [GO:0032040] | RNA binding [GO:0003723]; rRNA binding [GO:0019843]; snoRNA binding [GO:0030515]; structural constituent of ribosome [GO:0003735] | 14142.0588917566 | 0.189621789850701 | 0.436483515875661 | 0.795197129284149 |
| Q9BY32 | Q9BY32 | ITPA_HUMAN | Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) (Putative oncogene protein hlc14-06-p) | ITPA | chromosome organization [GO:0051276]; deoxyribonucleoside triphosphate catabolic process [GO:0009204]; ITP catabolic process [GO:0006193]; nucleoside triphosphate catabolic process [GO:0009143] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654] | dITP diphosphatase activity [GO:0035870]; identical protein binding [GO:0042802]; ITP diphosphatase activity [GO:0036220]; metal ion binding [GO:0046872]; nucleoside triphosphate diphosphatase activity [GO:0047429]; nucleotide binding [GO:0000166]; XTP diphosphatase activity [GO:0036222] | 14739.0160421309 | -0.130531505033111 | 0.436024894577477 | 0.795197129284149 |
| Q96AE7 | Q96AE7 | TTC17_HUMAN | Tetratricopeptide repeat protein 17 (TPR repeat protein 17) | TTC17 | actin filament polymerization [GO:0030041]; cilium organization [GO:0044782] | actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] | 5073.029736579119 | 0.299112189214122 | 0.436614590399398 | 0.795197129284149 | |
| Q14966 | Q14966 | ZN638_HUMAN | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | ZNF638 | regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] | cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | double-stranded DNA binding [GO:0003690]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] | 5488.1586851825905 | -0.403383343676329 | 0.435860378045654 | 0.795197129284149 |
| Q9NUY8 | Q9NUY8 | TBC23_HUMAN | TBC1 domain family member 23 (HCV non-structural protein 4A-transactivated protein 1) | TBC1D23 | brain development [GO:0007420]; embryonic brain development [GO:1990403]; neuron projection development [GO:0031175]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle tethering to Golgi [GO:0099041]; vesicle-mediated transport [GO:0016192] | cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; trans-Golgi network [GO:0005802] | 10643.74735323825 | -0.302999944714885 | 0.436938724916873 | 0.795531753013818 | |
| P98194 | P98194 | AT2C1_HUMAN | Calcium-transporting ATPase type 2C member 1 (ATPase 2C1) (EC 7.2.2.10) (ATP-dependent Ca(2+) pump PMR1) (Ca(2+)/Mn(2+)-ATPase 2C1) (Secretory pathway Ca(2+)-transporting ATPase type 1) (SPCA1) | ATP2C1 | actin cytoskeleton organization [GO:0030036]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; epidermis development [GO:0008544]; Golgi calcium ion homeostasis [GO:0032468]; Golgi calcium ion transport [GO:0032472]; intracellular calcium ion homeostasis [GO:0006874]; intracellular manganese ion homeostasis [GO:0030026]; manganese ion transport [GO:0006828]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998]; trans-Golgi network membrane organization [GO:0098629] | cis-Golgi network membrane [GO:0033106]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; manganese ion binding [GO:0030145]; metal ion binding [GO:0046872]; P-type calcium transporter activity [GO:0005388]; P-type manganese transporter activity [GO:0140613] | 15332.8005814922 | 0.130998119125603 | 0.437193134494396 | 0.79573925475273 |
| P25705 | P25705 | ATPA_HUMAN | ATP synthase subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) | ATP5F1A | ATP biosynthetic process [GO:0006754]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to nitric oxide [GO:0071732]; lipid metabolic process [GO:0006629]; negative regulation of endothelial cell proliferation [GO:0001937]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; response to ethanol [GO:0045471]; response to muscle activity [GO:0014850] | cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase, catalytic core [GO:0005754]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex [GO:0045259]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261] | ADP binding [GO:0043531]; angiostatin binding [GO:0043532]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; MHC class I protein binding [GO:0042288]; protease binding [GO:0002020]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; RNA binding [GO:0003723] | 131732.6706023895 | 0.0920264227121465 | 0.437496273082244 | 0.796035286860627 |
| P39748 | P39748 | FEN1_HUMAN | Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1) | FEN1 | base-excision repair, gap-filling [GO:0006287]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication, removal of RNA primer [GO:0043137]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; memory [GO:0007613]; nucleic acid metabolic process [GO:0090304]; positive regulation of sister chromatid cohesion [GO:0045876]; telomere maintenance via semi-conservative replication [GO:0032201]; UV protection [GO:0009650] | chromosome, telomeric region [GO:0000781]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] | 5'-3' exonuclease activity [GO:0008409]; 5'-flap endonuclease activity [GO:0017108]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; double-stranded DNA exodeoxyribonuclease activity [GO:0008309]; endonuclease activity [GO:0004519]; exonuclease activity [GO:0004527]; flap endonuclease activity [GO:0048256]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; RNA-DNA hybrid ribonuclease activity [GO:0004523] | 9250.053445863781 | 0.197099050063777 | 0.437918886380758 | 0.79654844630285 |
| Q08752 | Q08752 | PPID_HUMAN | Peptidyl-prolyl cis-trans isomerase D (PPIase D) (EC 5.2.1.8) (40 kDa peptidyl-prolyl cis-trans isomerase) (Cyclophilin-40) (CYP-40) (Cyclophilin-related protein) (Rotamase D) | PPID | apoptotic process [GO:0006915]; cellular response to UV-A [GO:0071492]; chaperone-mediated protein folding [GO:0061077]; lipid droplet organization [GO:0034389]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein secretion [GO:0050714]; positive regulation of viral genome replication [GO:0045070]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; protein transport [GO:0015031]; protein-containing complex assembly [GO:0065003]; viral release from host cell [GO:0019076] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | cyclosporin A binding [GO:0016018]; heat shock protein binding [GO:0031072]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; nuclear estrogen receptor binding [GO:0030331]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; transcription factor binding [GO:0008134] | 15612.53742689575 | 0.207075592389626 | 0.438286351320137 | 0.796705314911741 |
| P43307 | P43307 | SSRA_HUMAN | Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha) | SSR1 | cotranslational protein targeting to membrane [GO:0006613]; positive regulation of cell population proliferation [GO:0008284] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] | 216083.791383648 | 0.206130840225145 | 0.438854250023625 | 0.797481776983277 | |
| Q9HC38 | Q9HC38 | GLOD4_HUMAN | Glyoxalase domain-containing protein 4 | GLOD4 | extracellular exosome [GO:0070062]; mitochondrion [GO:0005739] | cadherin binding [GO:0045296] | 57947.309093495496 | 0.100614352307282 | 0.439412707829113 | 0.797764843335627 | |
| Q6P1N9 | Q6P1N9 | TATD1_HUMAN | Deoxyribonuclease TATDN1 (EC 3.1.21.-) (Hepatocarcinoma high expression protein) | TATDN1 | cytosol [GO:0005829]; nucleoplasm [GO:0005654] | 3'-5'-DNA exonuclease activity [GO:0008296]; metal ion binding [GO:0046872] | 14685.5886726131 | 0.210888595189935 | 0.439432417234467 | 0.797764843335627 | |
| P53582 | P53582 | MAP11_HUMAN | Methionine aminopeptidase 1 (MAP 1) (MetAP 1) (EC 3.4.11.18) (Peptidase M 1) | METAP1 | N-terminal protein amino acid modification [GO:0031365]; peptidyl-methionine modification [GO:0018206]; platelet aggregation [GO:0070527]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; regulation of translation [GO:0006417] | cytoplasm [GO:0005737]; cytosol [GO:0005829] | aminopeptidase activity [GO:0004177]; initiator methionyl aminopeptidase activity [GO:0004239]; metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006]; metalloexopeptidase activity [GO:0008235] | 25318.7816495056 | -0.139379337527822 | 0.440129543982698 | 0.798774502308126 |
| P27540 | P27540 | ARNT_HUMAN | Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta) | ARNT | cell differentiation [GO:0030154]; cellular response to oxidative stress [GO:0034599]; embryonic placenta development [GO:0001892]; negative regulation of inflammatory response [GO:0050728]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of glycolytic process [GO:0045821]; positive regulation of hormone biosynthetic process [GO:0046886]; positive regulation of protein sumoylation [GO:0033235]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hypoxia [GO:0001666] | aryl hydrocarbon receptor complex [GO:0034751]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear aryl hydrocarbon receptor complex [GO:0034753]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] | aryl hydrocarbon receptor binding [GO:0017162]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837] | 3169.468305911865 | -0.335720022764619 | 0.441295369579535 | 0.800121460492047 |
| Q96S52 | Q96S52 | PIGS_HUMAN | GPI transamidase component PIG-S (Phosphatidylinositol-glycan biosynthesis class S protein) | PIGS | attachment of GPI anchor to protein [GO:0016255] | endoplasmic reticulum membrane [GO:0005789]; GPI-anchor transamidase complex [GO:0042765]; membrane [GO:0016020] | 17640.4277200989 | 0.131818794090132 | 0.44115878069843 | 0.800121460492047 | |
| P0CG38 | P0CG38 | POTEI_HUMAN | POTE ankyrin domain family member I | POTEI | axonogenesis [GO:0007409]; cell motility [GO:0048870] | actin filament [GO:0005884]; axon [GO:0030424]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; NuA4 histone acetyltransferase complex [GO:0035267]; synapse [GO:0045202] | protein kinase binding [GO:0019901]; structural constituent of postsynaptic actin cytoskeleton [GO:0098973] | 152449.44194868748 | -0.526584792508938 | 0.44125208575931 | 0.800121460492047 |
| Q15388 | Q15388 | TOM20_HUMAN | Mitochondrial import receptor subunit TOM20 homolog (Mitochondrial 20 kDa outer membrane protein) (Outer mitochondrial membrane receptor Tom20) | TOMM20 | protein import into mitochondrial matrix [GO:0030150]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein targeting to mitochondrion [GO:0006626]; tRNA import into mitochondrion [GO:0016031] | cell periphery [GO:0071944]; migrasome [GO:0140494]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; sperm midpiece [GO:0097225]; TOM complex [GO:0140596] | mitochondrion targeting sequence binding [GO:0030943]; protein-transporting ATPase activity [GO:0015450]; unfolded protein binding [GO:0051082] | 18968.2263407596 | 0.138625306405936 | 0.4418092066779 | 0.800540762723691 |
| Q12882 | Q12882 | DPYD_HUMAN | Dihydropyrimidine dehydrogenase [NADP(+)] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase) | DPYD | beta-alanine biosynthetic process [GO:0019483]; CMP catabolic process [GO:0006248]; dCMP catabolic process [GO:0006249]; dUMP catabolic process [GO:0046079]; purine nucleobase catabolic process [GO:0006145]; pyrimidine nucleobase catabolic process [GO:0006208]; thymidine catabolic process [GO:0006214]; thymine catabolic process [GO:0006210]; UMP catabolic process [GO:0046050]; uracil catabolic process [GO:0006212] | cytoplasm [GO:0005737]; cytosol [GO:0005829] | 4 iron, 4 sulfur cluster binding [GO:0051539]; dihydropyrimidine dehydrogenase (NADP+) activity [GO:0017113]; flavin adenine dinucleotide binding [GO:0050660]; metal ion binding [GO:0046872]; NADP binding [GO:0050661]; protein homodimerization activity [GO:0042803]; uracil binding [GO:0002058] | 3848.32134136225 | 1.65413858414478 | 0.442395059227909 | 0.800547458871885 |
| Q8IXM3 | Q8IXM3 | RM41_HUMAN | Large ribosomal subunit protein mL41 (39S ribosomal protein L41, mitochondrial) (L41mt) (MRP-L41) (Bcl-2-interacting mitochondrial ribosomal protein L41) (Cell proliferation-inducing gene 3 protein) (MRP-L27 homolog) | MRPL41 | apoptotic process [GO:0006915]; cell cycle [GO:0007049]; mitochondrial translation [GO:0032543]; translation [GO:0006412] | mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 18904.28173136355 | 0.241830266692869 | 0.442428125111551 | 0.800547458871885 |
| Q14CX7 | Q14CX7 | NAA25_HUMAN | N-alpha-acetyltransferase 25, NatB auxiliary subunit (Mitochondrial distribution and morphology protein 20) (N-terminal acetyltransferase B complex subunit MDM20) (NatB complex subunit MDM20) (N-terminal acetyltransferase B complex subunit NAA25) (p120) | NAA25 | cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; NatB complex [GO:0031416] | 5809.91644027336 | -0.106482599975614 | 0.442519350721275 | 0.800547458871885 | ||
| Q9P016 | Q9P016 | THYN1_HUMAN | Thymocyte nuclear protein 1 (Thymocyte protein Thy28) | THYN1 | nucleus [GO:0005634] | 7459.54499343719 | -0.17764009957841 | 0.44244955756579 | 0.800547458871885 | ||
| Q9NR28 | Q9NR28 | DBLOH_HUMAN | Diablo IAP-binding mitochondrial protein (Diablo homolog, mitochondrial) (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac) [Cleaved into: Diablo IAP-binding mitochondrial protein, cleaved form] | DIABLO | activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; apoptotic process [GO:0006915]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic process [GO:0043065] | CD40 receptor complex [GO:0035631]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739] | 24297.9617027362 | 0.197482245515017 | 0.443274331254324 | 0.801293679755788 | |
| Q9HAT2 | Q9HAT2 | SIAE_HUMAN | Sialate O-acetylesterase (EC 3.1.1.53) (H-Lse) (Sialic acid-specific 9-O-acetylesterase) | SIAE | carbohydrate metabolic process [GO:0005975]; regulation of immune system process [GO:0002682] | extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lysosome [GO:0005764] | sialate 4-O-acetylesterase activity [GO:0106331]; sialate 9-O-acetylesterase activity [GO:0106330]; sialate O-acetylesterase activity [GO:0001681] | 26934.72619131295 | 0.146894740952519 | 0.443356104135968 | 0.801293679755788 |
| Q9UNH7 | Q9UNH7 | SNX6_HUMAN | Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed] | SNX6 | cellular response to amyloid-beta [GO:1904646]; cellular response to epidermal growth factor stimulus [GO:0071364]; intracellular protein transport [GO:0006886]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; regulation of macroautophagy [GO:0016241]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; retrograde transport, endosome to Golgi [GO:0042147] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; lysosome [GO:0005764]; nucleus [GO:0005634]; retromer complex [GO:0030904]; retromer, tubulation complex [GO:0030905]; tubular endosome [GO:0097422] | dynactin binding [GO:0034452]; phosphatidylinositol binding [GO:0035091]; protein homodimerization activity [GO:0042803]; type I transforming growth factor beta receptor binding [GO:0034713] | 39579.4581246479 | 0.0741753534646207 | 0.443109310021603 | 0.801293679755788 |
| Q9Y265 | Q9Y265 | RUVB1_HUMAN | RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha) | RUVBL1 | box C/D snoRNP assembly [GO:0000492]; cell cycle [GO:0007049]; cell division [GO:0051301]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]; telomere maintenance [GO:0000723] | centrosome [GO:0005813]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; extracellular exosome [GO:0070062]; Ino80 complex [GO:0031011]; membrane [GO:0016020]; MLL1 complex [GO:0071339]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; R2TP complex [GO:0097255]; ribonucleoprotein complex [GO:1990904]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]; Swr1 complex [GO:0000812] | ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase binding [GO:0051117]; cadherin binding [GO:0045296]; DNA helicase activity [GO:0003678]; TBP-class protein binding [GO:0017025]; TFIID-class transcription factor complex binding [GO:0001094]; transcription coactivator activity [GO:0003713] | 68533.04050504554 | 0.0526208151334654 | 0.443821565596584 | 0.801623522687359 |
| O75436 | O75436 | VP26A_HUMAN | Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) (hVPS26) | VPS26A | endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886]; regulation of macroautophagy [GO:0016241]; retrograde transport, endosome to Golgi [GO:0042147] | cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; lysosome [GO:0005764]; retromer complex [GO:0030904]; retromer, cargo-selective complex [GO:0030906]; tubular endosome [GO:0097422]; vesicle [GO:0031982] | 51434.70055267365 | 0.16828453926928 | 0.444342508383101 | 0.802053090952103 | |
| P35606 | P35606 | COPB2_HUMAN | Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102) | COPB2 | endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890] | COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133] | structural molecule activity [GO:0005198] | 64415.4357025645 | -0.129967550156925 | 0.445687758364651 | 0.804225107928062 |
| Q13454 | Q13454 | TUSC3_HUMAN | Tumor suppressor candidate 3 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3) (Oligosaccharyl transferase subunit TUSC3) (Magnesium uptake/transporter TUSC3) (Protein N33) | TUSC3 | cognition [GO:0050890]; magnesium ion transport [GO:0015693]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; transmembrane transport [GO:0055085] | endoplasmic reticulum membrane [GO:0005789]; mitochondrion [GO:0005739]; oligosaccharyltransferase complex [GO:0008250]; plasma membrane [GO:0005886] | magnesium ion transmembrane transporter activity [GO:0015095] | 34842.111321102 | -0.102647131042672 | 0.446222030724911 | 0.804676647386169 |
| Q96RR4 | Q96RR4 | KKCC2_HUMAN | Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) | CAMKK2 | calcium-mediated signaling [GO:0019722]; CAMKK-AMPK signaling cascade [GO:0061762]; cellular response to reactive oxygen species [GO:0034614]; MAPK cascade [GO:0000165]; positive regulation of autophagy of mitochondrion [GO:1903599]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein phosphorylation [GO:0001934]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of protein kinase activity [GO:0045859] | cytosol [GO:0005829]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654] | ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713] | 3613.87067003544 | -0.21792245971285 | 0.446691970275764 | 0.804771672776169 |
| Q6UWF9 | Q6UWF9 | F180A_HUMAN | Protein FAM180A | FAM180A | extracellular region [GO:0005576] | 4499.075286155665 | 0.435516489747612 | 0.446700831429765 | 0.804771672776169 | ||
| Q96FT9 | Q96FT9 | IFT43_HUMAN | Intraflagellar transport protein 43 homolog | IFT43 | cilium assembly [GO:0060271]; intraciliary retrograde transport [GO:0035721] | centriolar satellite [GO:0034451]; centriole [GO:0005814]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; intraciliary transport particle A [GO:0030991]; microtubule cytoskeleton [GO:0015630] | 3051.6510568593403 | -0.661186855651188 | 0.44664883737786 | 0.804771672776169 | |
| Q52LJ0 | Q52LJ0 | FA98B_HUMAN | Protein FAM98B | FAM98B | positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; protein methylation [GO:0006479]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388] | cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA-splicing ligase complex [GO:0072669] | identical protein binding [GO:0042802]; protein methyltransferase activity [GO:0008276]; RNA binding [GO:0003723] | 25230.78409142725 | 0.0744506787746071 | 0.447559853534896 | 0.806062978426167 |
| O75746 | O75746 | S2512_HUMAN | Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (Araceli hiperlarga) (Aralar) (Aralar1) (Mitochondrial aspartate glutamate carrier 1) (Solute carrier family 25 member 12) | SLC25A12 | aspartate family amino acid metabolic process [GO:0009066]; aspartate transmembrane transport [GO:0015810]; gluconeogenesis [GO:0006094]; L-glutamate transmembrane transport [GO:0015813]; malate-aspartate shuttle [GO:0043490]; response to calcium ion [GO:0051592] | membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] | 3-sulfino-L-alanine: proton, glutamate antiporter activity [GO:0000514]; acidic amino acid transmembrane transporter activity [GO:0015172]; aspartate:glutamate, proton antiporter activity [GO:0000515]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamate transmembrane transporter activity [GO:0005313] | 12715.3033503006 | -0.165928545547386 | 0.447904247233526 | 0.806426903344506 |
| Q16610 | Q16610 | ECM1_HUMAN | Extracellular matrix protein 1 (Secretory component p85) | ECM1 | angiogenesis [GO:0001525]; biomineral tissue development [GO:0031214]; chondrocyte development [GO:0002063]; endochondral bone growth [GO:0003416]; inflammatory response [GO:0006954]; negative regulation of bone mineralization [GO:0030502]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of peptidase activity [GO:0010466]; ossification [GO:0001503]; positive regulation of angiogenesis [GO:0045766]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of endothelial cell proliferation [GO:0001938]; regulation of bone mineralization [GO:0030500]; regulation of T cell migration [GO:2000404]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type 2 immune response [GO:0002828]; signal transduction [GO:0007165] | collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet dense granule lumen [GO:0031089] | interleukin-2 receptor binding [GO:0005134]; protease binding [GO:0002020] | 32912.3251869783 | -0.174698606269437 | 0.448215826348208 | 0.806731534971076 |
| Q8NEJ9 | Q8NEJ9 | NGDN_HUMAN | Neuroguidin (Centromere accumulated nuclear protein 1) (CANu1) (EIF4E-binding protein) | NGDN | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; negative regulation of protein localization to plasma membrane [GO:1903077]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of translation at postsynapse [GO:0140245]; ribosomal small subunit biogenesis [GO:0042274] | axon [GO:0030424]; chromosome, centromeric region [GO:0000775]; dendrite [GO:0030425]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perforant pathway to dendrate granule cell synapse [GO:0140240]; postsynapse [GO:0098794]; small-subunit processome [GO:0032040] | RNA binding [GO:0003723] | 10894.745465854001 | 0.20221958643315 | 0.448770978415461 | 0.807328234909204 |
| P46778 | P46778 | RL21_HUMAN | Large ribosomal subunit protein eL21 (60S ribosomal protein L21) | RPL21 | cytoplasmic translation [GO:0002181]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; synapse [GO:0045202] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 182278.230746212 | 0.17041515548097 | 0.448974809071462 | 0.807328234909204 |
| Q8NI36 | Q8NI36 | WDR36_HUMAN | WD repeat-containing protein 36 (T-cell activation WD repeat-containing protein) (TA-WDRP) | WDR36 | response to stimulus [GO:0050896]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; visual perception [GO:0007601] | nucleoplasm [GO:0005654]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040] | RNA binding [GO:0003723] | 6042.77573298911 | -0.184950199223994 | 0.448933422899106 | 0.807328234909204 |
| Q8TAT6 | Q8TAT6 | NPL4_HUMAN | Nuclear protein localization protein 4 homolog (Protein NPL4) | NPLOC4 | Golgi organization [GO:0007030]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of type I interferon production [GO:0032480]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent protein catabolic process [GO:0006511] | cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear outer membrane-endoplasmic reticulum membrane network [GO:0042175]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; UFD1-NPL4 complex [GO:0036501]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098] | ATPase binding [GO:0051117]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625] | 19876.730176932 | 0.0862454343945554 | 0.449117831858822 | 0.807329199020331 |
| Q8IY31 | Q8IY31 | IFT20_HUMAN | Intraflagellar transport protein 20 homolog (hIFT20) | IFT20 | cardiac muscle cell differentiation [GO:0055007]; centrosome localization [GO:0051642]; cilium assembly [GO:0060271]; cochlea development [GO:0090102]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of planar polarity [GO:0001736]; inner ear receptor cell stereocilium organization [GO:0060122]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; kidney development [GO:0001822]; neural precursor cell proliferation [GO:0061351]; opsin transport [GO:0036372]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of cilium assembly [GO:0045724]; protein localization to cilium [GO:0061512]; protein localization to Golgi apparatus [GO:0034067]; protein localization to plasma membrane [GO:0072659]; protein transmembrane transport [GO:0071806]; regulation of autophagosome assembly [GO:2000785]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of cilium assembly [GO:1902017]; regulation of platelet-derived growth factor receptor-alpha signaling pathway [GO:2000583]; smoothened signaling pathway [GO:0007224]; spermatogenesis [GO:0007283]; visual learning [GO:0008542] | acrosomal vesicle [GO:0001669]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; dendrite terminus [GO:0044292]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intraciliary transport particle B [GO:0030992]; kinociliary basal body [GO:1902636]; manchette [GO:0002177]; microvillus [GO:0005902]; motile cilium [GO:0031514]; photoreceptor connecting cilium [GO:0032391]; photoreceptor outer segment [GO:0001750]; stereocilium [GO:0032420] | opsin binding [GO:0002046]; small GTPase binding [GO:0031267] | 4408.79615169635 | -0.952307037187044 | 0.449701678022729 | 0.808122330376397 |
| P18615 | P18615 | NELFE_HUMAN | Negative elongation factor E (NELF-E) (RNA-binding protein RD) | NELFE | negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of protein modification process [GO:0031401]; positive regulation of transcription by RNA polymerase II [GO:0045944] | chromatin [GO:0000785]; NELF complex [GO:0032021]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | chromatin binding [GO:0003682]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] | 11874.056229516751 | 0.150869699681468 | 0.450707768097188 | 0.809673498426971 |
| Q03001 | Q03001 | DYST_HUMAN | Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) | DST | cell adhesion [GO:0007155]; cell motility [GO:0048870]; cytoskeleton organization [GO:0007010]; hemidesmosome assembly [GO:0031581]; integrin-mediated signaling pathway [GO:0007229]; intermediate filament bundle assembly [GO:0045110]; intermediate filament cytoskeleton organization [GO:0045104]; maintenance of cell polarity [GO:0030011]; microtubule cytoskeleton organization [GO:0000226]; response to wounding [GO:0009611]; retrograde axonal transport [GO:0008090]; wound healing [GO:0042060] | actin cytoskeleton [GO:0015629]; axon [GO:0030424]; axon cytoplasm [GO:1904115]; basal plasma membrane [GO:0009925]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; focal adhesion [GO:0005925]; H zone [GO:0031673]; hemidesmosome [GO:0030056]; intermediate filament cytoskeleton [GO:0045111]; keratin filament [GO:0045095]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; microtubule plus-end [GO:0035371]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; stress fiber [GO:0001725]; Z disc [GO:0030018] | actin binding [GO:0003779]; calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; keratin filament binding [GO:1990254]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; protein homodimerization activity [GO:0042803]; structural molecule activity [GO:0005198] | 6226.06126255173 | -0.271380936339454 | 0.451011484127909 | 0.809705661935593 |
| Q16774 | Q16774 | KGUA_HUMAN | Guanylate kinase (EC 2.7.4.8) (GMP kinase) (Guanylate kinase 1) | GUK1 | dATP metabolic process [GO:0046060]; dGDP biosynthetic process [GO:0006185]; dGMP metabolic process [GO:0046054]; GDP biosynthetic process [GO:0046711]; GDP-mannose metabolic process [GO:0019673]; glycoprotein transport [GO:0034436]; nucleobase-containing small molecule interconversion [GO:0015949]; phosphorylation [GO:0016310]; purine nucleotide metabolic process [GO:0006163]; xenobiotic metabolic process [GO:0006805] | cytosol [GO:0005829]; photoreceptor inner segment [GO:0001917] | ATP binding [GO:0005524]; guanylate kinase activity [GO:0004385] | 64378.59233276585 | 0.166564757585155 | 0.451004767894253 | 0.809705661935593 |
| Q8WUX9 | Q8WUX9 | CHMP7_HUMAN | Charged multivesicular body protein 7 (Chromatin-modifying protein 7) | CHMP7 | autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; ESCRT III complex disassembly [GO:1904903]; exit from mitosis [GO:0010458]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; protein localization to chromatin [GO:0071168]; protein transport [GO:0015031]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle budding from membrane [GO:0006900]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702] | amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; chromatin [GO:0000785]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] | 10226.551798744851 | 0.154260014810683 | 0.451701208661903 | 0.810290034805894 | |
| Q9P2X0 | Q9P2X0 | DPM3_HUMAN | Dolichol-phosphate mannosyltransferase subunit 3 (Dolichol-phosphate mannose synthase subunit 3) (DPM synthase subunit 3) (Dolichyl-phosphate beta-D-mannosyltransferase subunit 3) (Mannose-P-dolichol synthase subunit 3) (MPD synthase subunit 3) (Prostin-1) | DPM3 | carbohydrate metabolic process [GO:0005975]; dolichol metabolic process [GO:0019348]; GPI anchor biosynthetic process [GO:0006506]; protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan [GO:0018406]; protein mannosylation [GO:0035268]; protein O-linked mannosylation [GO:0035269]; regulation of protein stability [GO:0031647] | dolichol-phosphate-mannose synthase complex [GO:0033185]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mannosyltransferase complex [GO:0031501]; membrane [GO:0016020] | enzyme activator activity [GO:0008047] | 4017.99452640449 | -0.649202165199344 | 0.451909020470636 | 0.810290034805894 |
| Q13641 | Q13641 | TPBG_HUMAN | Trophoblast glycoprotein (5T4 oncofetal antigen) (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein) (M6P1) (Wnt-activated inhibitory factor 1) (WAIF1) | TPBG | cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; dendrite arborization [GO:0140059]; mesenchymal cell migration [GO:0090497]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; olfactory learning [GO:0008355]; positive regulation of chemotaxis [GO:0050921]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of synapse assembly [GO:0051965]; protein localization to plasma membrane [GO:0072659]; synaptic transmission, GABAergic [GO:0051932] | axon terminus [GO:0043679]; cell surface [GO:0009986]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] | 148421.0155061 | 0.234498730843866 | 0.451901933440796 | 0.810290034805894 | |
| Q9NRX4 | Q9NRX4 | PHP14_HUMAN | 14 kDa phosphohistidine phosphatase (EC 3.9.1.3) (Phosphohistidine phosphatase 1) (PHPT1) (Protein histidine phosphatase) (PHP) (Protein janus-A homolog) | PHPT1 | actin cytoskeleton organization [GO:0030036]; lamellipodium organization [GO:0097581]; negative regulation of ATP citrate synthase activity [GO:2000984]; negative regulation of lyase activity [GO:0051350]; negative regulation of T cell receptor signaling pathway [GO:0050860]; peptidyl-histidine dephosphorylation [GO:0035971]; positive regulation of cell motility [GO:2000147]; protein dephosphorylation [GO:0006470] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; leading edge of lamellipodium [GO:0061851]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] | actin filament binding [GO:0051015]; calcium channel inhibitor activity [GO:0019855]; protein histidine phosphatase activity [GO:0101006]; transmembrane transporter binding [GO:0044325] | 54901.2055436562 | 0.291146710035269 | 0.453078104088444 | 0.81135920915459 |
| Q9NXA8 | Q9NXA8 | SIR5_HUMAN | NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 2.3.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5) | SIRT5 | mitochondrion organization [GO:0007005]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; peptidyl-lysine demalonylation [GO:0036047]; peptidyl-lysine desuccinylation [GO:0036049]; protein deacetylation [GO:0006476]; protein deglutarylation [GO:0061698]; protein demalonylation [GO:0036046]; protein desuccinylation [GO:0036048]; regulation of ketone biosynthetic process [GO:0010566]; response to nutrient levels [GO:0031667] | cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634] | NAD+ binding [GO:0070403]; NAD-dependent histone deacetylase activity [GO:0017136]; NAD-dependent protein deacetylase activity [GO:0034979]; protein-glutaryllysine deglutarylase activity [GO:0061697]; protein-malonyllysine demalonylase activity [GO:0036054]; protein-succinyllysine desuccinylase activity [GO:0036055]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270] | 5085.051064179025 | 0.126432271255716 | 0.453064590523595 | 0.81135920915459 |
| Q9UMR5 | Q9UMR5 | PPT2_HUMAN | Lysosomal thioesterase PPT2 (PPT-2) (EC 3.1.2.-) (S-thioesterase G14) | PPT2 | fatty-acyl-CoA biosynthetic process [GO:0046949] | extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764] | palmitoyl hydrolase activity [GO:0098599]; thiolester hydrolase activity [GO:0016790] | 23047.71317721215 | 0.380697866601941 | 0.4535849507797 | 0.81201021520309 |
| P14621 | P14621 | ACYP2_HUMAN | Acylphosphatase-2 (EC 3.6.1.7) (Acylphosphatase, muscle type isozyme) (Acylphosphate phosphohydrolase 2) | ACYP2 | phosphate-containing compound metabolic process [GO:0006796] | acylphosphatase activity [GO:0003998]; identical protein binding [GO:0042802] | 27770.5534277504 | -0.252025664589847 | 0.454796441103501 | 0.812448235032975 | |
| Q7Z494 | Q7Z494 | NPHP3_HUMAN | Nephrocystin-3 | NPHP3 | atrial septum development [GO:0003283]; cilium assembly [GO:0060271]; convergent extension [GO:0060026]; convergent extension involved in gastrulation [GO:0060027]; determination of intestine left/right asymmetry [GO:0071908]; determination of left/right symmetry [GO:0007368]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; determination of stomach left/right asymmetry [GO:0071909]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; establishment or maintenance of cell polarity [GO:0007163]; extracellular matrix organization [GO:0030198]; heart looping [GO:0001947]; kidney development [GO:0001822]; kidney morphogenesis [GO:0060993]; lipid metabolic process [GO:0006629]; lung development [GO:0030324]; maintenance of animal organ identity [GO:0048496]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; non-motile cilium assembly [GO:1905515]; photoreceptor cell maintenance [GO:0045494]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]; ureter development [GO:0072189]; Wnt signaling pathway [GO:0016055] | ciliary base [GO:0097546]; ciliary inversin compartment [GO:0097543]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular region [GO:0005576] | 3833.361458780585 | -0.366721084904162 | 0.454607034696809 | 0.812448235032975 | |
| Q08623 | Q08623 | HDHD1_HUMAN | Pseudouridine-5'-phosphatase (EC 3.1.3.96) (Haloacid dehalogenase-like hydrolase domain-containing protein 1) (Haloacid dehalogenase-like hydrolase domain-containing protein 1A) (Protein GS1) (Pseudouridine-5'-monophosphatase) (5'-PsiMPase) | PUDP | nucleotide metabolic process [GO:0009117] | cytosol [GO:0005829] | metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; pseudouridine 5'-phosphatase activity [GO:1990738] | 6285.890481260874 | -0.202696382291974 | 0.454046549606111 | 0.812448235032975 |
| Q9Y3A4 | Q9Y3A4 | RRP7A_HUMAN | Ribosomal RNA-processing protein 7 homolog A (Gastric cancer antigen Zg14) | RRP7A | blastocyst formation [GO:0001825]; cilium disassembly [GO:0061523]; protein localization to nucleolus [GO:1902570]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; ribosome biogenesis [GO:0042254]; rRNA processing [GO:0006364] | centrosome [GO:0005813]; cilium [GO:0005929]; CURI complex [GO:0032545]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; UTP-C complex [GO:0034456] | RNA binding [GO:0003723] | 8288.40617237165 | 0.150047644928888 | 0.454833357134591 | 0.812448235032975 |
| Q15427 | Q15427 | SF3B4_HUMAN | Splicing factor 3B subunit 4 (Pre-mRNA-splicing factor SF3b 49 kDa subunit) (Spliceosome-associated protein 49) (SAP 49) | SF3B4 | mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; U2-type prespliceosome assembly [GO:1903241] | nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684] | RNA binding [GO:0003723]; splicing factor binding [GO:1990935] | 12495.4832169814 | 0.228246514780025 | 0.454558154181211 | 0.812448235032975 |
| Q15714 | Q15714 | T22D1_HUMAN | TSC22 domain family protein 1 (Cerebral protein 2) (HUCEP-2) (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein) | TSC22D1 | negative regulation of apoptotic process [GO:0043066]; negative regulation of hematopoietic stem cell proliferation [GO:1902034]; negative regulation of programmed cell death [GO:0043069]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of programmed cell death [GO:0043068]; positive regulation of transforming growth factor beta activation [GO:1901390]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | identical protein binding [GO:0042802] | 21751.2671489531 | -0.336150271570862 | 0.454677615468453 | 0.812448235032975 |
| Q13442 | Q13442 | HAP28_HUMAN | 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) | PDAP1 | signal transduction [GO:0007165] | cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; plasma membrane [GO:0005886] | RNA binding [GO:0003723] | 269925.41799406253 | 0.302051261628091 | 0.455145418664517 | 0.812749430240515 |
| O14979 | O14979 | HNRDL_HUMAN | Heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like) (hnRNP DL) (AU-rich element RNA-binding factor) (JKT41-binding protein) (Protein laAUF1) | HNRNPDL | regulation of gene expression [GO:0010468]; RNA processing [GO:0006396] | cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] | DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; poly(A) binding [GO:0008143]; poly(G) binding [GO:0034046]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697] | 27096.7458134673 | 0.193559754465521 | 0.455771862246211 | 0.813611648231579 |
| Q96AD5 | Q96AD5 | PLPL2_HUMAN | Patatin-like phospholipase domain-containing protein 2 (EC 3.1.1.3) (Adipose triglyceride lipase) (Calcium-independent phospholipase A2-zeta) (iPLA2-zeta) (EC 3.1.1.4) (Desnutrin) (Pigment epithelium-derived factor receptor) (PEDF-R) (TTS2.2) (Transport-secretion protein 2) (TTS2) | PNPLA2 | acylglycerol acyl-chain remodeling [GO:0036155]; diacylglycerol biosynthetic process [GO:0006651]; lipid droplet disassembly [GO:1905691]; lipid homeostasis [GO:0055088]; lipid storage [GO:0019915]; negative regulation of sequestering of triglyceride [GO:0010891]; positive regulation of triglyceride catabolic process [GO:0010898]; triglyceride catabolic process [GO:0019433] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] | acylglycerol O-acyltransferase activity [GO:0016411]; diolein transacylation activity [GO:0051265]; lipoprotein lipase activity [GO:0004465]; mono-olein transacylation activity [GO:0051264]; phospholipase A2 activity [GO:0004623]; retinyl-palmitate esterase activity [GO:0050253]; triglyceride lipase activity [GO:0004806] | 4338.224988096605 | 0.293218860420217 | 0.456694102112641 | 0.815001191360701 |
| O43768 | O43768 | ENSA_HUMAN | Alpha-endosulfine (ARPP-19e) | ENSA | cell division [GO:0051301]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic cell cycle [GO:0000278]; negative regulation of protein dephosphorylation [GO:0035308]; regulation of insulin secretion [GO:0050796]; response to nutrient [GO:0007584] | cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] | ion channel inhibitor activity [GO:0008200]; phosphatase inhibitor activity [GO:0019212]; potassium channel inhibitor activity [GO:0019870]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase inhibitor activity [GO:0004864]; protein phosphatase regulator activity [GO:0019888]; signaling receptor binding [GO:0005102] | 36911.88243903135 | 0.325914849995093 | 0.457051427283246 | 0.815125397225959 |
| P62847 | P62847 | RS24_HUMAN | Small ribosomal subunit protein eS24 (40S ribosomal protein S24) | RPS24 | cytoplasmic translation [GO:0002181]; erythrocyte homeostasis [GO:0034101]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small ribosomal subunit [GO:0015935]; small-subunit processome [GO:0032040] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; translation initiation factor binding [GO:0031369] | 472573.231643212 | 0.198249780442229 | 0.457493255153466 | 0.81565663426669 |
| O96013 | O96013 | PAK4_HUMAN | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) | PAK4 | apoptotic process [GO:0006915]; cell cycle [GO:0007049]; cell migration [GO:0016477]; cellular response to organic cyclic compound [GO:0071407]; cytoskeleton organization [GO:0007010]; dendritic spine development [GO:0060996]; intracellular signal transduction [GO:0035556]; negative regulation of endothelial cell apoptotic process [GO:2000352]; phosphorylation [GO:0016310]; positive regulation of angiogenesis [GO:0045766]; regulation of cell growth [GO:0001558]; regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165] | adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794] | ATP binding [GO:0005524]; cadherin binding involved in cell-cell adhesion [GO:0098641]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | 7369.847724595351 | -0.182070155524191 | 0.457679407327907 | 0.81573184080526 |
| Q9BXB4 | Q9BXB4 | OSB11_HUMAN | Oxysterol-binding protein-related protein 11 (ORP-11) (OSBP-related protein 11) | OSBPL11 | fat cell differentiation [GO:0045444]; positive regulation of sequestering of triglyceride [GO:0010890] | cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; nucleoplasm [GO:0005654] | sterol binding [GO:0032934]; sterol transporter activity [GO:0015248] | 6064.182734887195 | 0.170552677305824 | 0.458234987306037 | 0.815969671511007 |
| Q9Y6W3 | Q9Y6W3 | CAN7_HUMAN | Calpain-7 (EC 3.4.22.-) (PalB homolog) (PalBH) | CAPN7 | positive regulation of epithelial cell migration [GO:0010634]; proteolysis [GO:0006508]; self proteolysis [GO:0097264] | centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] | calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; cysteine-type endopeptidase activity [GO:0004197]; endopeptidase activity [GO:0004175]; MIT domain binding [GO:0090541] | 2980.888018843485 | -0.325690062630932 | 0.458613308596312 | 0.816128607167333 |
| P50747 | P50747 | BPL1_HUMAN | Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)] | HLCS | biotin metabolic process [GO:0006768]; post-translational protein modification [GO:0043687]; response to biotin [GO:0070781] | chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear lamina [GO:0005652]; nuclear matrix [GO:0016363] | ATP binding [GO:0005524]; biotin binding [GO:0009374]; biotin-[acetyl-CoA-carboxylase] ligase activity [GO:0004077]; biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity [GO:0004078]; biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity [GO:0004079]; biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity [GO:0004080]; biotin-protein ligase activity [GO:0018271]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802] | 14567.544239910501 | -0.253607595564059 | 0.458894934592767 | 0.816357519435672 |
| P38159 | P38159 | RBMX_HUMAN | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RBMX | cellular response to interleukin-1 [GO:0071347]; membrane protein ectodomain proteolysis [GO:0006509]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; osteoblast differentiation [GO:0001649]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homooligomerization [GO:0051260]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; transcription by RNA polymerase II [GO:0006366] | catalytic step 2 spliceosome [GO:0071013]; euchromatin [GO:0000791]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681]; supraspliceosomal complex [GO:0044530] | chromatin binding [GO:0003682]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] | 142286.2960869715 | 0.188650532911169 | 0.459314347238694 | 0.816847172459021 |
| Q9Y3Z3 | Q9Y3Z3 | SAMH1_HUMAN | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) (hSAMHD1) | SAMHD1 | dATP catabolic process [GO:0046061]; defense response to virus [GO:0051607]; deoxyribonucleotide catabolic process [GO:0009264]; dGTP catabolic process [GO:0006203]; DNA damage response [GO:0006974]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair via homologous recombination [GO:0000724]; immune response [GO:0006955]; innate immune response [GO:0045087]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; protein homotetramerization [GO:0051289]; regulation of innate immune response [GO:0045088]; somatic hypermutation of immunoglobulin genes [GO:0016446] | nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; site of double-strand break [GO:0035861]; tetraspanin-enriched microdomain [GO:0097197] | deoxynucleoside triphosphate hydrolase activity [GO:0106375]; dGTP binding [GO:0032567]; dGTPase activity [GO:0008832]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; RNA nuclease activity [GO:0004540]; single-stranded DNA binding [GO:0003697]; triphosphoric monoester hydrolase activity [GO:0016793]; zinc ion binding [GO:0008270] | 9090.24245215748 | -0.214704367509263 | 0.459967557952535 | 0.817401030595352 |
| Q8IVF4 | Q8IVF4 | DYH10_HUMAN | Dynein axonemal heavy chain 10 (Axonemal beta dynein heavy chain 10) (Ciliary dynein heavy chain 10) | DNAH10 | cilium movement involved in cell motility [GO:0060294] | 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] | 47328.866053289996 | -0.222776192768449 | 0.461078538620424 | 0.818186971444824 |
| Q5BJD5 | Q5BJD5 | TM41B_HUMAN | Transmembrane protein 41B (Protein stasimon) | TMEM41B | autophagosome assembly [GO:0000045]; intracellular lipid transport [GO:0032365]; modulation by host of viral RNA genome replication [GO:0044830]; nervous system development [GO:0007399] | endoplasmic reticulum membrane [GO:0005789]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233] | phospholipid scramblase activity [GO:0017128] | 8652.72122055717 | 0.16189770707475 | 0.461067155465611 | 0.818186971444824 |
| P14866 | P14866 | HNRPL_HUMAN | Heterogeneous nuclear ribonucleoprotein L (hnRNP L) | HNRNPL | mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; RNA processing [GO:0006396] | chromatin [GO:0000785]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ribonucleoprotein granule [GO:0035770] | mRNA binding [GO:0003729]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; transcription cis-regulatory region binding [GO:0000976] | 54542.360052479344 | -0.0872214081394632 | 0.461445044759066 | 0.818324764821555 |
| Q9UNM6 | Q9UNM6 | PSD13_HUMAN | 26S proteasome non-ATPase regulatory subunit 13 (26S proteasome regulatory subunit RPN9) (26S proteasome regulatory subunit S11) (26S proteasome regulatory subunit p40.5) | PSMD13 | meiosis I [GO:0007127]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; ubiquitin-dependent protein catabolic process [GO:0006511] | cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; proteasome regulatory particle, lid subcomplex [GO:0008541]; secretory granule lumen [GO:0034774] | structural molecule activity [GO:0005198] | 52624.034456377645 | 0.101137796046822 | 0.461430743548835 | 0.818324764821555 |
| Q9NX46 | Q9NX46 | ADPRS_HUMAN | ADP-ribosylhydrolase ARH3 (ADP-ribose glycohydrolase ARH3) (ADP-ribosylhydrolase 3) (O-acetyl-ADP-ribose deacetylase ARH3) (EC 3.5.1.-) (Poly(ADP-ribose) glycohydrolase ARH3) (EC 3.2.1.143) ([Protein ADP-ribosylarginine] hydrolase-like protein 2) ([Protein ADP-ribosylserine] hydrolase) (EC 3.2.2.-) | ADPRS | base-excision repair, gap-filling [GO:0006287]; cellular response to superoxide [GO:0071451]; DNA repair [GO:0006281]; negative regulation of necroptotic process [GO:0060546]; peptidyl-serine ADP-deribosylation [GO:0140290] | cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734] | ADP-ribosylserine hydrolase activity [GO:0140292]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; magnesium ion binding [GO:0000287]; O-acetyl-ADP-ribose deacetylase activity [GO:0061463]; poly(ADP-ribose) glycohydrolase activity [GO:0004649] | 42254.892923245454 | 0.120117306261599 | 0.461734597420158 | 0.818582049118465 |
| O75113 | O75113 | N4BP1_HUMAN | NEDD4-binding protein 1 (N4BP1) (EC 3.1.-.-) | N4BP1 | cellular response to UV [GO:0034644]; innate immune response [GO:0045087]; negative regulation of cytokine production [GO:0001818]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of viral genome replication [GO:0045071]; regulation of innate immune response [GO:0045088] | cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; PML body [GO:0016605] | mRNA binding [GO:0003729]; RNA nuclease activity [GO:0004540]; ubiquitin binding [GO:0043130] | 7797.848007342315 | -0.170663894819832 | 0.46229623427598 | 0.818915616381237 |
| P61247 | P61247 | RS3A_HUMAN | Small ribosomal subunit protein eS1 (40S ribosomal protein S3a) (v-fos transformation effector protein) (Fte-1) | RPS3A | cell differentiation [GO:0030154]; cytoplasmic translation [GO:0002181]; negative regulation of apoptotic process [GO:0043066]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]; translational initiation [GO:0006413] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; small-subunit processome [GO:0032040]; synapse [GO:0045202] | mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 125544.915096288 | 0.107704725617833 | 0.462336142371333 | 0.818915616381237 |
| Q9Y4E8 | Q9Y4E8 | UBP15_HUMAN | Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Unph-2) (Unph4) | USP15 | BMP signaling pathway [GO:0030509]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of antifungal innate immune response [GO:1905035]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of RIG-I signaling pathway [GO:1900246]; protein deubiquitination [GO:0016579]; protein K27-linked deubiquitination [GO:1990167]; proteolysis [GO:0006508]; regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator [GO:1902238]; transcription elongation-coupled chromatin remodeling [GO:0140673]; transforming growth factor beta receptor signaling pathway [GO:0007179] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005]; identical protein binding [GO:0042802]; K48-linked deubiquitinase activity [GO:1990380]; SMAD binding [GO:0046332]; transforming growth factor beta receptor binding [GO:0005160]; ubiquitin modification-dependent histone binding [GO:0061649] | 8213.345546854835 | -0.182824073302691 | 0.462723208291363 | 0.819309280680894 |
| Q16799 | Q16799 | RTN1_HUMAN | Reticulon-1 (Neuroendocrine-specific protein) | RTN1 | brain development [GO:0007420]; endoplasmic reticulum tubular network formation [GO:0071787]; negative regulation of amyloid-beta formation [GO:1902430]; neuron differentiation [GO:0030182] | dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069] | 18149.6182196022 | -0.133690725730659 | 0.463745802372699 | 0.820607031931204 | |
| Q86VN1 | Q86VN1 | VPS36_HUMAN | Vacuolar protein-sorting-associated protein 36 (ELL-associated protein of 45 kDa) (ESCRT-II complex subunit VPS36) | VPS36 | macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328] | cytosol [GO:0005829]; endosome [GO:0005768]; ESCRT II complex [GO:0000814]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; lysosome [GO:0005764]; nucleus [GO:0005634] | phosphatidylinositol-3-phosphate binding [GO:0032266]; ubiquitin binding [GO:0043130] | 8901.283603037191 | -0.10710349889688 | 0.463730183086132 | 0.820607031931204 |
| Q9NYF8 | Q9NYF8 | BCLF1_HUMAN | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | BCLAF1 | apoptotic process [GO:0006915]; cellular response to leukemia inhibitory factor [GO:1990830]; DNA damage response [GO:0006974]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription initiation [GO:2000144]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of transcription by RNA polymerase II [GO:0045944] | cytoplasm [GO:0005737]; mediator complex [GO:0016592]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | DNA binding [GO:0003677]; RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712] | 22718.059634752048 | -0.188765875199891 | 0.464505020701623 | 0.821527638506248 |
| O75940 | O75940 | SPF30_HUMAN | Survival of motor neuron-related-splicing factor 30 (30 kDa splicing factor SMNrp) (SMN-related protein) (Survival motor neuron domain-containing protein 1) | SMNDC1 | apoptotic process [GO:0006915]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing, via transesterification reactions [GO:0000375] | Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011] | RNA binding [GO:0003723] | 13202.85995392045 | 0.214492263677511 | 0.464556045494885 | 0.821527638506248 |
| Q86YS6 | Q86YS6 | RAB43_HUMAN | Ras-related protein Rab-43 (Ras-related protein Rab-41) | RAB43 | autophagosome assembly [GO:0000045]; cellular response to type II interferon [GO:0071346]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; phagosome maturation [GO:0090382]; retrograde transport, plasma membrane to Golgi [GO:0035526]; virion assembly [GO:0019068] | endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; trans-Golgi network membrane [GO:0032588] | GTP binding [GO:0005525]; GTPase activity [GO:0003924] | 8497.64941051937 | -0.368686131005339 | 0.46502297094268 | 0.822096771719571 |
| O15121 | O15121 | DEGS1_HUMAN | Sphingolipid delta(4)-desaturase DES1 (EC 1.14.19.17) (Cell migration-inducing gene 15 protein) (Degenerative spermatocyte homolog 1) (Dihydroceramide desaturase-1) (Membrane lipid desaturase) (Retinol isomerase) (EC 5.2.1.-) | DEGS1 | ceramide biosynthetic process [GO:0046513]; myelin maintenance [GO:0043217]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579] | electron transfer activity [GO:0009055]; retinol isomerase activity [GO:0050251]; sphingolipid delta-4 desaturase activity [GO:0042284] | 24467.8552955728 | 0.212821924670709 | 0.466107060974417 | 0.823085691357816 |
| Q14517 | Q14517 | FAT1_HUMAN | Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form] | FAT1 | actin filament organization [GO:0007015]; adherens junction organization [GO:0034332]; anatomical structure morphogenesis [GO:0009653]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; cell-cell signaling [GO:0007267]; cellular response to angiotensin [GO:1904385]; epithelial cell morphogenesis [GO:0003382]; establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis [GO:0003412]; establishment or maintenance of cell polarity [GO:0007163]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; lens development in camera-type eye [GO:0002088]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754] | adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; catenin complex [GO:0016342]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] | cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] | 8954.360382499846 | -0.364880222961351 | 0.465905904333851 | 0.823085691357816 |
| P49458 | P49458 | SRP09_HUMAN | Signal recognition particle 9 kDa protein (SRP9) | SRP9 | negative regulation of translational elongation [GO:0045900]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614] | cytosol [GO:0005829]; signal recognition particle receptor complex [GO:0005785]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786] | 7S RNA binding [GO:0008312]; RNA binding [GO:0003723]; signal recognition particle binding [GO:0005047] | 77137.4933990568 | 0.136519351055555 | 0.466779968958149 | 0.823765415826689 |
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| Q15149 | |||||||||
| Q99715 | |||||||||
| P02452 | |||||||||
| P02751 | |||||||||
| P98160 | |||||||||
| P08123 | |||||||||
| P02461 | |||||||||
| P07996 | |||||||||
| Q8WWI1 | |||||||||
| P05997 | |||||||||
| P20908 | |||||||||
| Q8WUJ3 | |||||||||
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