Selected Cell
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stat_data__min_2_Peptides
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| Q9P2X3 | Q9P2X3 | IMPCT_HUMAN | Protein IMPACT (Imprinted and ancient gene protein homolog) | IMPACT | cellular response to amino acid starvation [GO:0034198]; GCN2-mediated signaling [GO:0140469]; intracellular signal transduction [GO:0035556]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron projection extension [GO:1990138]; positive regulation of neuron differentiation [GO:0045666]; regulation of cytoplasmic translational initiation in response to stress [GO:1990611]; regulation of translational initiation [GO:0006446] | cytoplasm [GO:0005737] | actin binding [GO:0003779]; protein sequestering activity [GO:0140311]; ribosome binding [GO:0043022] | 18774.15654156475 | -0.143957909987443 | 0.224025037856405 | 0.519576694430777 |
| Q9Y6R0 | Q9Y6R0 | NUMBL_HUMAN | Numb-like protein (Numb-related protein) (Numb-R) | NUMBL | adherens junction organization [GO:0034332]; axonogenesis [GO:0007409]; cytokine-mediated signaling pathway [GO:0019221]; lateral ventricle development [GO:0021670]; nervous system development [GO:0007399]; neuroblast division in subventricular zone [GO:0021849]; positive regulation of neurogenesis [GO:0050769]; protein metabolic process [GO:0019538] | cytoplasm [GO:0005737] | 18256.50935217295 | -0.263920999982781 | 0.224208318289249 | 0.519789006312146 | |
| Q8NBS9 | Q8NBS9 | TXND5_HUMAN | Thioredoxin domain-containing protein 5 (EC 1.8.4.-) (EC 5.3.4.1) (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Thioredoxin-like protein p46) | TXNDC5 | negative regulation of apoptotic process [GO:0043066]; protein folding [GO:0006457] | azurophil granule lumen [GO:0035578]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202] | protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035] | 158953.1534494395 | -0.201338760709147 | 0.224323291937921 | 0.519842851582929 |
| Q9HD33 | Q9HD33 | RM47_HUMAN | Large ribosomal subunit protein uL29m (39S ribosomal protein L47, mitochondrial) (L47mt) (MRP-L47) (Nasopharyngeal carcinoma metastasis-related protein 1) | MRPL47 | mitochondrial translation [GO:0032543] | mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] | structural constituent of ribosome [GO:0003735] | 12185.8150507132 | 0.278010162431658 | 0.224850010930713 | 0.52042490275058 |
| Q96HS1 | Q96HS1 | PGAM5_HUMAN | Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC 3.1.3.16) (Bcl-XL-binding protein v68) (Phosphoglycerate mutase family member 5) | PGAM5 | macroautophagy [GO:0016236]; necroptotic process [GO:0070266]; negative regulation of cold-induced thermogenesis [GO:0120163]; positive regulation of mitochondrial fission [GO:0090141] | mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] | GTPase activator activity [GO:0005096]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein serine/threonine phosphatase activity [GO:0004722]; protein-containing complex binding [GO:0044877] | 15655.688206226048 | 0.148504767019077 | 0.224835374460132 | 0.52042490275058 |
| Q6NUS6 | Q6NUS6 | TECT3_HUMAN | Tectonic-3 | TCTN3 | apoptotic process [GO:0006915]; cilium assembly [GO:0060271]; positive regulation of apoptotic process [GO:0043065]; smoothened signaling pathway [GO:0007224] | ciliary membrane [GO:0060170]; nucleus [GO:0005634] | 3687.975315884895 | 0.512679066217846 | 0.224667630433188 | 0.52042490275058 | |
| P78417 | P78417 | GSTO1_HUMAN | Glutathione S-transferase omega-1 (GSTO-1) (EC 2.5.1.18) (Glutathione S-transferase omega 1-1) (GSTO 1-1) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) (S-(Phenacyl)glutathione reductase) (SPG-R) | GSTO1 | cellular response to arsenic-containing substance [GO:0071243]; glutathione metabolic process [GO:0006749]; L-ascorbic acid metabolic process [GO:0019852]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [GO:0014810]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; xenobiotic catabolic process [GO:0042178] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] | glutathione dehydrogenase (ascorbate) activity [GO:0045174]; glutathione transferase activity [GO:0004364]; methylarsonate reductase activity [GO:0050610]; oxidoreductase activity [GO:0016491] | 85741.917712085 | 0.106202843478556 | 0.225174365060778 | 0.520665647545739 |
| Q13523 | Q13523 | PRP4K_HUMAN | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | PRP4K | mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; phosphorylation [GO:0016310]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]; spliceosomal snRNP assembly [GO:0000387]; spliceosomal tri-snRNP complex assembly [GO:0000244] | catalytic step 2 spliceosome [GO:0071013]; kinetochore [GO:0000776]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723] | 8085.67769818918 | -0.163932967271727 | 0.225229703871268 | 0.520665647545739 |
| Q15019 | Q15019 | SEPT2_HUMAN | Septin-2 (Neural precursor cell expressed developmentally down-regulated protein 5) (NEDD-5) | SEPTIN2 | cell differentiation [GO:0030154]; cilium assembly [GO:0060271]; cytoskeleton-dependent cytokinesis [GO:0061640]; regulation of exocytosis [GO:0017157]; smoothened signaling pathway [GO:0007224]; spermatogenesis [GO:0007283] | actin cytoskeleton [GO:0015629]; axoneme [GO:0005930]; cell division site [GO:0032153]; ciliary membrane [GO:0060170]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; non-motile cilium [GO:0097730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor connecting cilium [GO:0032391]; plasma membrane [GO:0005886]; septin complex [GO:0031105]; septin ring [GO:0005940]; sperm annulus [GO:0097227]; spindle [GO:0005819]; synaptic vesicle [GO:0008021] | cadherin binding [GO:0045296]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090] | 75480.80270315806 | 0.17029165338904 | 0.2252186826389 | 0.520665647545739 |
| P0CW19;P0CW20 | P0CW19 | LIMS3_HUMAN | LIM and senescent cell antigen-like-containing domain protein 3 (Particularly interesting new Cys-His protein 3) (PINCH-3) | LIMS3 | cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026] | cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925] | metal ion binding [GO:0046872] | 10410.4383018904 | 0.534091983771585 | 0.225510726162943 | 0.521102681255804 |
| P42771 | P42771 | CDN2A_HUMAN | Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A) | CDKN2A | cell cycle [GO:0007049]; cellular senescence [GO:0090398]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphorylation [GO:0042326]; positive regulation of macrophage apoptotic process [GO:2000111]; positive regulation of smooth muscle cell apoptotic process [GO:0034393]; Ras protein signal transduction [GO:0007265]; regulation of cell cycle [GO:0051726]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; replicative senescence [GO:0090399] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; senescence-associated heterochromatin focus [GO:0035985] | cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; NF-kappaB binding [GO:0051059]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723] | 73970.3085230966 | 0.222126330997204 | 0.226106017892392 | 0.52189799250247 |
| O60783 | O60783 | RT14_HUMAN | Small ribosomal subunit protein uS14m (28S ribosomal protein S14, mitochondrial) (MRP-S14) (S14mt) | MRPS14 | mitochondrial translation [GO:0032543]; translation [GO:0006412] | mitochondrial inner membrane [GO:0005743]; mitochondrial ribosome [GO:0005761]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 31584.210209627352 | 0.408297978943246 | 0.2261312339558 | 0.52189799250247 |
| O75131 | O75131 | CPNE3_HUMAN | Copine-3 (Copine III) | CPNE3 | cellular response to calcium ion [GO:0071277]; cellular response to growth factor stimulus [GO:0071363]; ERBB2 signaling pathway [GO:0038128]; positive regulation of cell migration [GO:0030335] | azurophil granule membrane [GO:0035577]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674]; receptor tyrosine kinase binding [GO:0030971]; RNA binding [GO:0003723] | 39307.86296038145 | 0.0946094816173053 | 0.226596002037651 | 0.522757714798587 |
| Q99519 | Q99519 | NEUR1_HUMAN | Sialidase-1 (EC 3.2.1.18) (Acetylneuraminyl hydrolase) (G9 sialidase) (Lysosomal sialidase) (N-acetyl-alpha-neuraminidase 1) | NEU1 | ganglioside catabolic process [GO:0006689]; oligosaccharide catabolic process [GO:0009313] | cell junction [GO:0030054]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580] | alpha-sialidase activity [GO:0016997]; exo-alpha-(2->3)-sialidase activity [GO:0052794]; exo-alpha-(2->6)-sialidase activity [GO:0052795]; exo-alpha-(2->8)-sialidase activity [GO:0052796]; exo-alpha-sialidase activity [GO:0004308] | 17834.09693721015 | 0.233227093623468 | 0.226906174904556 | 0.523260230772981 |
| Q9BVA0 | Q9BVA0 | KTNB1_HUMAN | Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin) | KATNB1 | cell division [GO:0051301]; cytoplasmic microtubule organization [GO:0031122]; microtubule depolymerization [GO:0007019]; microtubule severing [GO:0051013]; mitotic chromosome movement towards spindle pole [GO:0007079]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of apoptotic process [GO:0043065]; positive regulation of microtubule depolymerization [GO:0031117]; positive regulation of neuron projection development [GO:0010976]; protein targeting [GO:0006605] | centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; katanin complex [GO:0008352]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819]; spindle pole [GO:0000922] | ATPase regulator activity [GO:0060590]; dynein complex binding [GO:0070840]; microtubule binding [GO:0008017]; protein heterodimerization activity [GO:0046982] | 5042.23004358479 | -0.551886921020114 | 0.227268542679807 | 0.523882653711874 |
| O95352 | O95352 | ATG7_HUMAN | Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7) (Autophagy-related protein 7) (APG7-like) (hAGP7) (Ubiquitin-activating enzyme E1-like protein) | ATG7 | autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; cellular response to hyperoxia [GO:0071455]; cellular response to nitrogen starvation [GO:0006995]; cellular response to starvation [GO:0009267]; defense response to virus [GO:0051607]; macroautophagy [GO:0016236]; mitophagy [GO:0000423]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein modification process [GO:0031401]; protein lipidation [GO:0006497]; protein modification by small protein conjugation [GO:0032446]; protein transport [GO:0015031]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511] | axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; phagophore assembly site [GO:0000407]; secretory granule lumen [GO:0034774] | Atg12 activating enzyme activity [GO:0019778]; Atg8 activating enzyme activity [GO:0019779]; protein homodimerization activity [GO:0042803] | 12827.0108297927 | -0.0995439894844498 | 0.227556145254619 | 0.524332297280467 |
| O95999 | O95999 | BCL10_HUMAN | B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10) | BCL10 | adaptive immune response [GO:0002250]; antifungal innate immune response [GO:0061760]; B cell apoptotic process [GO:0001783]; canonical NF-kappaB signal transduction [GO:0007249]; cellular defense response [GO:0006968]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; immunoglobulin mediated immune response [GO:0016064]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of mature B cell apoptotic process [GO:0002906]; neural tube closure [GO:0001843]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of lymphotoxin A production [GO:0032761]; positive regulation of mast cell cytokine production [GO:0032765]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphorylation [GO:0042327]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell receptor signaling pathway [GO:0050862]; programmed cell death [GO:0012501]; protein homooligomerization [GO:0051260]; response to food [GO:0032094]; T cell apoptotic process [GO:0070231]; T cell receptor signaling pathway [GO:0050852]; toll-like receptor signaling pathway [GO:0002224] | CBM complex [GO:0032449]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; lysosome [GO:0005764]; membrane raft [GO:0045121]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; polkadots [GO:0002096]; protein-containing complex [GO:0032991] | CARD domain binding [GO:0050700]; general transcription initiation factor binding [GO:0140296]; identical protein binding [GO:0042802]; kinase activator activity [GO:0019209]; NF-kappaB binding [GO:0051059]; protease binding [GO:0002020]; protein kinase B binding [GO:0043422]; protein self-association [GO:0043621]; protein-containing complex binding [GO:0044877]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase binding [GO:0031625] | 11551.76432870575 | 0.295827529608399 | 0.227983191625042 | 0.524676183488012 |
| Q15291 | Q15291 | RBBP5_HUMAN | Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3) | RBBP5 | DNA damage response [GO:0006974]; response to estrogen [GO:0043627]; transcription initiation-coupled chromatin remodeling [GO:0045815] | histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; MLL3/4 complex [GO:0044666]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188] | histone binding [GO:0042393]; transcription cis-regulatory region binding [GO:0000976] | 3853.168619476245 | -0.201454547659975 | 0.227906073989339 | 0.524676183488012 |
| O60762 | O60762 | DPM1_HUMAN | Dolichol-phosphate mannosyltransferase subunit 1 (EC 2.4.1.83) (Dolichol-phosphate mannose synthase subunit 1) (DPM synthase subunit 1) (Dolichyl-phosphate beta-D-mannosyltransferase subunit 1) (Mannose-P-dolichol synthase subunit 1) (MPD synthase subunit 1) | DPM1 | dolichol metabolic process [GO:0019348]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; GDP-mannose metabolic process [GO:0019673]; GPI anchor biosynthetic process [GO:0006506]; protein mannosylation [GO:0035268]; protein N-linked glycosylation via asparagine [GO:0018279]; protein O-linked mannosylation [GO:0035269] | dolichol-phosphate-mannose synthase complex [GO:0033185]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleus [GO:0005634] | alcohol binding [GO:0043178]; dolichyl-phosphate beta-D-mannosyltransferase activity [GO:0004582]; dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannose binding [GO:0005537]; metal ion binding [GO:0046872] | 25503.999612902 | 0.180300722659155 | 0.228088210621139 | 0.524704750864546 |
| Q9H5N1 | Q9H5N1 | RABE2_HUMAN | Rab GTPase-binding effector protein 2 (Rabaptin-5beta) | RABEP2 | cell projection organization [GO:0030030]; endocytosis [GO:0006897]; protein transport [GO:0015031]; regulation of cilium assembly [GO:1902017] | centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231] | growth factor activity [GO:0008083]; GTPase activator activity [GO:0005096] | 21893.0903349369 | 0.138145584707314 | 0.228264824495833 | 0.524897928406409 |
| Q9NQW7 | Q9NQW7 | XPP1_HUMAN | Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble) | XPNPEP1 | bradykinin catabolic process [GO:0010815]; negative regulation of programmed cell death [GO:0043069]; proteolysis [GO:0006508] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062] | aminopeptidase activity [GO:0004177]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; protein homodimerization activity [GO:0042803] | 21696.65155973515 | -0.0907206716817842 | 0.228697456048469 | 0.525679426357252 |
| Q96RU3 | Q96RU3 | FNBP1_HUMAN | Formin-binding protein 1 (Formin-binding protein 17) (hFBP17) | FNBP1 | endocytosis [GO:0006897]; signal transduction [GO:0007165] | cell cortex [GO:0005938]; clathrin-coated pit [GO:0005905]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; plasma membrane [GO:0005886] | identical protein binding [GO:0042802]; lipid binding [GO:0008289] | 10240.647842463939 | 0.194418027163383 | 0.229131604991274 | 0.526463776918313 |
| Q969G5 | Q969G5 | CAVN3_HUMAN | Caveolae-associated protein 3 (Cavin-3) (Protein kinase C delta-binding protein) (Serum deprivation response factor-related gene product that binds to C-kinase) (hSRBC) | CAVIN3 | circadian regulation of gene expression [GO:0032922]; cortical actin cytoskeleton organization [GO:0030866]; negative regulation of fermentation [GO:1901003]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; positive regulation of ERK1 and ERK2 cascade [GO:0070374] | caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991] | protein kinase C binding [GO:0005080] | 126894.6098137555 | 0.232853103296726 | 0.229511739997215 | 0.526909853656492 |
| Q9NPB8 | Q9NPB8 | GPCP1_HUMAN | Glycerophosphocholine phosphodiesterase GPCPD1 (EC 3.1.4.2) (Glycerophosphodiester phosphodiesterase 5) | GPCPD1 | glycerophospholipid catabolic process [GO:0046475]; skeletal muscle tissue development [GO:0007519] | cytosol [GO:0005829] | glycerophosphocholine phosphodiesterase activity [GO:0047389]; starch binding [GO:2001070] | 7824.20628042937 | 0.747922454313362 | 0.230145913714647 | 0.528151780926363 |
| O43572 | O43572 | AKA10_HUMAN | A-kinase anchor protein 10, mitochondrial (AKAP-10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2) (Protein kinase A-anchoring protein 10) (PRKA10) | AKAP10 | protein localization [GO:0008104]; signal transduction [GO:0007165] | cytosol [GO:0005829]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] | protein kinase A binding [GO:0051018] | 3491.70402909479 | -0.264939293769699 | 0.230589172782578 | 0.528896438216987 |
| Q12959 | Q12959 | DLG1_HUMAN | Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) | DLG1 | actin filament organization [GO:0007015]; actin filament polymerization [GO:0030041]; amyloid precursor protein metabolic process [GO:0042982]; astral microtubule organization [GO:0030953]; bicellular tight junction assembly [GO:0070830]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell-cell adhesion [GO:0098609]; chemical synaptic transmission [GO:0007268]; cortical actin cytoskeleton organization [GO:0030866]; cortical microtubule organization [GO:0043622]; embryonic skeletal system morphogenesis [GO:0048704]; endothelial cell proliferation [GO:0001935]; establishment of centrosome localization [GO:0051660]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; hard palate development [GO:0060022]; immunological synapse formation [GO:0001771]; lens development in camera-type eye [GO:0002088]; membrane raft organization [GO:0031579]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of p38MAPK cascade [GO:1903753]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; peristalsis [GO:0030432]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein localization to plasma membrane [GO:0072659]; protein-containing complex localization [GO:0031503]; receptor clustering [GO:0043113]; regulation of cell shape [GO:0008360]; regulation of membrane potential [GO:0042391]; regulation of myelination [GO:0031641]; regulation of potassium ion export across plasma membrane [GO:1903764]; regulation of potassium ion import [GO:1903286]; regulation of protein localization to synapse [GO:1902473]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903760]; reproductive structure development [GO:0048608]; smooth muscle tissue development [GO:0048745]; T cell proliferation [GO:0042098] | adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cell projection membrane [GO:0031253]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; immunological synapse [GO:0001772]; intercalated disc [GO:0014704]; lateral loop [GO:0043219]; lateral plasma membrane [GO:0016328]; membrane raft [GO:0045121]; microtubule [GO:0005874]; MPP7-DLG1-LIN7 complex [GO:0097025]; myelin sheath abaxonal region [GO:0035748]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; node of Ranvier [GO:0033268]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; sarcolemma [GO:0042383]; synaptic membrane [GO:0097060] | cadherin binding [GO:0045296]; cytoskeletal protein binding [GO:0008092]; guanylate kinase activity [GO:0004385]; kinase binding [GO:0019900]; L27 domain binding [GO:0097016]; molecular adaptor activity [GO:0060090]; phosphatase binding [GO:0019902]; phosphoprotein phosphatase activity [GO:0004721]; potassium channel regulator activity [GO:0015459]; structural constituent of postsynaptic density [GO:0098919]; transmembrane transporter binding [GO:0044325] | 9130.39748442983 | -0.246225596049831 | 0.230750440393998 | 0.528896438216987 |
| Q15369 | Q15369 | ELOC_HUMAN | Elongin-C (EloC) (Elongin 15 kDa subunit) (RNA polymerase II transcription factor SIII subunit C) (SIII p15) (Transcription elongation factor B polypeptide 1) | ELOC | protein ubiquitination [GO:0016567]; regulation of transcription by RNA polymerase II [GO:0006357]; target-directed miRNA degradation [GO:0140958]; transcription initiation at RNA polymerase II promoter [GO:0006367]; ubiquitin-dependent protein catabolic process [GO:0006511] | Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul5-RING ubiquitin ligase complex [GO:0031466]; cytosol [GO:0005829]; elongin complex [GO:0070449]; nucleoplasm [GO:0005654] | protein-macromolecule adaptor activity [GO:0030674]; transcription corepressor binding [GO:0001222] | 189197.3400846225 | 0.123235180022685 | 0.230678752748045 | 0.528896438216987 |
| Q9Y3E1 | Q9Y3E1 | HDGR3_HUMAN | Hepatoma-derived growth factor-related protein 3 (HRP-3) (Hepatoma-derived growth factor 2) (HDGF-2) | HDGFL3 | chromatin remodeling [GO:0006338]; microtubule polymerization [GO:0046785]; negative regulation of microtubule depolymerization [GO:0007026]; neuron projection development [GO:0031175] | cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | growth factor activity [GO:0008083]; microtubule binding [GO:0008017]; tubulin binding [GO:0015631] | 42590.6911100723 | -0.284273012767159 | 0.230893385969148 | 0.529010078811642 |
| Q8IWZ3 | Q8IWZ3 | ANKH1_HUMAN | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | ANKHD1 | innate immune response [GO:0045087] | cytoplasm [GO:0005737] | RNA binding [GO:0003723] | 6659.5804996312145 | -3.15853970905857 | 0.230994117522927 | 0.529026948215402 |
| Q9UKK3 | Q9UKK3 | PARP4_HUMAN | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | PARP4 | DNA damage response [GO:0006974]; DNA repair [GO:0006281]; inflammatory response [GO:0006954]; protein modification process [GO:0036211]; regulation of telomerase activity [GO:0051972]; response to xenobiotic stimulus [GO:0009410] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spindle microtubule [GO:0005876] | DNA binding [GO:0003677]; enzyme binding [GO:0019899]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404]; nucleotidyltransferase activity [GO:0016779] | 14792.28609773315 | -0.318082914851829 | 0.231518399379504 | 0.529799374347444 |
| P82912 | P82912 | RT11_HUMAN | Small ribosomal subunit protein uS11m (28S ribosomal protein S11, mitochondrial) (MRP-S11) (S11mt) (Cervical cancer proto-oncogene 2 protein) (HCC-2) | MRPS11 | mitochondrial translation [GO:0032543]; translation [GO:0006412] | cytosolic small ribosomal subunit [GO:0022627]; mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 4338.039284728255 | 0.447761067786802 | 0.231702032201846 | 0.529879905416262 |
| Q02878 | Q02878 | RL6_HUMAN | Large ribosomal subunit protein eL6 (60S ribosomal protein L6) (Neoplasm-related protein C140) (Tax-responsive enhancer element-binding protein 107) (TaxREB107) | RPL6 | cytoplasmic translation [GO:0002181]; regulation of DNA-templated transcription [GO:0006355]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; rough endoplasmic reticulum [GO:0005791] | cadherin binding [GO:0045296]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 136700.2286502125 | 0.153774114644955 | 0.231740629301359 | 0.529879905416262 |
| P48060 | P48060 | GLIP1_HUMAN | Glioma pathogenesis-related protein 1 (GliPR 1) (Protein RTVP-1) | GLIPR1 | azurophil granule membrane [GO:0035577]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886] | 19686.385948992553 | 0.429880828062179 | 0.231885478332025 | 0.529997224779853 | ||
| P81605 | P81605 | DCD_HUMAN | Dermcidin (EC 3.4.-.-) (Preproteolysin) [Cleaved into: Survival-promoting peptide; DCD-1] | DCD | defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; killing by host of symbiont cells [GO:0051873]; proteolysis [GO:0006508] | extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020] | lipid binding [GO:0008289]; metal ion binding [GO:0046872]; monoatomic ion channel activity [GO:0005216]; peptidase activity [GO:0008233]; RNA binding [GO:0003723] | 7852.957035275011 | -1.40539816655258 | 0.232202187071289 | 0.530083348186934 |
| Q08379 | Q08379 | GOGA2_HUMAN | Golgin subfamily A member 2 (130 kDa cis-Golgi matrix protein) (GM130) (GM130 autoantigen) (Golgin-95) | GOLGA2 | asymmetric cell division [GO:0008356]; centrosome cycle [GO:0007098]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi disassembly [GO:0090166]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; meiotic spindle assembly [GO:0090306]; microtubule nucleation [GO:0007020]; mitotic spindle assembly [GO:0090307]; negative regulation of autophagy [GO:0010507]; negative regulation of protein binding [GO:0032091]; positive regulation of protein glycosylation [GO:0060050]; protein glycosylation [GO:0006486]; protein homotetramerization [GO:0051289]; protein transport [GO:0015031]; spindle assembly [GO:0051225] | cis-Golgi network [GO:0005801]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi cis cisterna [GO:0000137]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; microtubule [GO:0005874]; mitotic spindle [GO:0072686]; spindle pole [GO:0000922] | cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; importin-alpha family protein binding [GO:0061676]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; syntaxin binding [GO:0019905] | 13886.0181542192 | -0.165888004483451 | 0.232195551756628 | 0.530083348186934 |
| Q8N573 | Q8N573 | OXR1_HUMAN | Oxidation resistance protein 1 | OXR1 | adult walking behavior [GO:0007628]; cellular response to hydroperoxide [GO:0071447]; negative regulation of cellular response to oxidative stress [GO:1900408]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; neuron apoptotic process [GO:0051402]; response to oxidative stress [GO:0006979] | mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634] | oxidoreductase activity [GO:0016491] | 5712.307976437531 | -0.31326964791583 | 0.233126966252105 | 0.531976395805246 |
| Q9GZU8 | Q9GZU8 | PIP30_HUMAN | PSME3-interacting protein (NEFA-interacting nuclear protein NIP30) (PA28G-interacting protein) | PSME3IP1 | negative regulation of proteasomal protein catabolic process [GO:1901799]; negative regulation of protein binding [GO:0032091] | intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | 9175.333748830104 | 0.259464052308428 | 0.233430849851382 | 0.532455392615914 | |
| Q14738 | Q14738 | 2A5D_HUMAN | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta) | PPP2R5D | negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; nervous system development [GO:0007399]; positive regulation of protein dephosphorylation [GO:0035307]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165] | cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159] | phosphoprotein phosphatase activity [GO:0004721]; protein phosphatase activator activity [GO:0072542]; protein phosphatase regulator activity [GO:0019888] | 19784.07819790405 | -0.0715761138513588 | 0.233755335152371 | 0.532980977454058 |
| P46019 | P46019 | KPB2_HUMAN | Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit) | PHKA2 | carbohydrate metabolic process [GO:0005975]; generation of precursor metabolites and energy [GO:0006091]; glycogen metabolic process [GO:0005977]; protein modification process [GO:0036211] | cytosol [GO:0005829]; phosphorylase kinase complex [GO:0005964]; plasma membrane [GO:0005886] | calmodulin binding [GO:0005516]; phosphorylase kinase activity [GO:0004689] | 3177.033854328215 | -0.276456298070288 | 0.233942481250964 | 0.533193120984698 |
| Q8N122 | Q8N122 | RPTOR_HUMAN | Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein) | RPTOR | cellular response to amino acid stimulus [GO:0071230]; cellular response to glucose stimulus [GO:0071333]; cellular response to hypoxia [GO:0071456]; cellular response to leucine [GO:0071233]; cellular response to nutrient levels [GO:0031669]; cellular response to osmotic stress [GO:0071470]; cellular response to starvation [GO:0009267]; DNA damage response [GO:0006974]; negative regulation of autophagy [GO:0010507]; positive regulation of cell growth [GO:0030307]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of glycolytic process [GO:0045821]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of odontoblast differentiation [GO:1901331]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of pentose-phosphate shunt [GO:1905857]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transcription by RNA polymerase III [GO:0045945]; regulation of autophagy [GO:0010506]; regulation of cell growth [GO:0001558]; regulation of cell size [GO:0008361]; response to xenobiotic stimulus [GO:0009410]; social behavior [GO:0035176]; TOR signaling [GO:0031929]; TORC1 signaling [GO:0038202] | cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; TORC1 complex [GO:0031931] | 14-3-3 protein binding [GO:0071889]; enzyme-substrate adaptor activity [GO:0140767]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein serine/threonine kinase inhibitor activity [GO:0030291]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267] | 6662.278952687506 | -0.322695503456026 | 0.235146990436932 | 0.535507575488608 |
| Q9UNK0 | Q9UNK0 | STX8_HUMAN | Syntaxin-8 | STX8 | cellular response to type II interferon [GO:0071346]; early endosome to late endosome transport [GO:0045022]; intracellular protein transport [GO:0006886]; regulation of protein localization to plasma membrane [GO:1903076]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] | early endosome [GO:0005769]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; late endosome [GO:0005770]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; SNARE complex [GO:0031201]; trans-Golgi network [GO:0005802]; vesicle [GO:0031982] | chloride channel inhibitor activity [GO:0019869]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]; ubiquitin protein ligase binding [GO:0031625] | 15309.37778270455 | 0.205066223604733 | 0.236461090221345 | 0.538283863878723 |
| P63241 | P63241 | IF5A1_HUMAN | Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D) | EIF5A | cellular response to virus [GO:0098586]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translational elongation [GO:0045901]; positive regulation of translational termination [GO:0045905]; translational elongation [GO:0006414]; tumor necrosis factor-mediated signaling pathway [GO:0033209] | annulate lamellae [GO:0005642]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear pore [GO:0005643]; nucleus [GO:0005634] | ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746]; U6 snRNA binding [GO:0017070] | 311756.45957035746 | 0.22636285151857 | 0.237247368261371 | 0.539206001328541 |
| Q16777;Q6FI13 | Q16777 | H2A2C_HUMAN | Histone H2A type 2-C (H2A-clustered histone 20) (Histone H2A-GL101) (Histone H2A/q) | H2AC20 | heterochromatin organization [GO:0070828] | extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634] | nucleosomal DNA binding [GO:0031492]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] | 58928.909522121 | 0.681646268385307 | 0.23738087981454 | 0.539206001328541 |
| Q9Y666 | Q9Y666 | S12A7_HUMAN | Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4) | SLC12A7 | ammonium import across plasma membrane [GO:0140157]; cell volume homeostasis [GO:0006884]; cellular response to glucose stimulus [GO:0071333]; chemical synaptic transmission [GO:0007268]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; monoatomic ion transport [GO:0006811]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805] | plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; synapse [GO:0045202] | ammonium transmembrane transporter activity [GO:0008519]; potassium:chloride symporter activity [GO:0015379]; protein kinase binding [GO:0019901] | 2830.774766018625 | 0.46128142317586 | 0.237437164368992 | 0.539206001328541 |
| Q13596 | Q13596 | SNX1_HUMAN | Sorting nexin-1 | SNX1 | early endosome to Golgi transport [GO:0034498]; intracellular protein transport [GO:0006886]; lamellipodium morphogenesis [GO:0072673]; receptor internalization [GO:0031623]; retrograde transport, endosome to Golgi [GO:0042147] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; lysosome [GO:0005764]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; retromer complex [GO:0030904]; retromer, tubulation complex [GO:0030905]; vesicle [GO:0031982] | cadherin binding [GO:0045296]; epidermal growth factor receptor binding [GO:0005154]; identical protein binding [GO:0042802]; insulin receptor binding [GO:0005158]; leptin receptor binding [GO:1990460]; phosphatidylinositol binding [GO:0035091]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; transferrin receptor binding [GO:1990459] | 54727.4926579824 | 0.116425612817447 | 0.23727412684195 | 0.539206001328541 |
| Q9Y2H1 | Q9Y2H1 | ST38L_HUMAN | Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2) | STK38L | intracellular signal transduction [GO:0035556]; negative regulation of autophagy [GO:0010507]; postsynapse organization [GO:0099173]; protein phosphorylation [GO:0006468]; regulation of cellular component organization [GO:0051128] | actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020] | actin binding [GO:0003779]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | 6664.2272856862 | -0.224771505936837 | 0.237632065256305 | 0.539432404544159 |
| Q8N5M4 | Q8N5M4 | TTC9C_HUMAN | Tetratricopeptide repeat protein 9C (TPR repeat protein 9C) | TTC9C | 37666.284182915246 | 0.18196989368557 | 0.23790571796807 | 0.539837323991623 | |||
| P18124 | P18124 | RL7_HUMAN | Large ribosomal subunit protein uL30 (60S ribosomal protein L7) | RPL7 | cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904] | DNA binding [GO:0003677]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 188974.2510328745 | 0.176687718496449 | 0.238052722844595 | 0.539954654778812 |
| Q8N9T8 | Q8N9T8 | KRI1_HUMAN | Protein KRI1 homolog | KRI1 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447] | 90S preribosome [GO:0030686]; nucleolus [GO:0005730] | RNA binding [GO:0003723] | 3557.88632831379 | 0.223268036826829 | 0.238703122486567 | 0.541213242100395 |
| O15111 | O15111 | IKKA_HUMAN | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | CHUK | anatomical structure morphogenesis [GO:0009653]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to cadmium ion [GO:0071276]; cellular response to reactive oxygen species [GO:0034614]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to virus [GO:0098586]; I-kappaB phosphorylation [GO:0007252]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; response to acetate [GO:0010034]; response to amino acid [GO:0043200]; response to cholecystokinin [GO:0061847]; response to hydroperoxide [GO:0033194]; response to lipopolysaccharide [GO:0032496]; response to toxic substance [GO:0009636]; response to virus [GO:0009615]; response to xenobiotic stimulus [GO:0009410]; Rho protein signal transduction [GO:0007266]; skeletal muscle contraction [GO:0003009]; striated muscle cell differentiation [GO:0051146]; toll-like receptor 4 signaling pathway [GO:0034142]; tumor necrosis factor-mediated signaling pathway [GO:0033209] | CD40 receptor complex [GO:0035631]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; IkappaB kinase complex [GO:0008385]; nucleoplasm [GO:0005654] | ATP binding [GO:0005524]; IkappaB kinase activity [GO:0008384]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; transferrin receptor binding [GO:1990459] | 4075.44216205095 | -0.271023514152822 | 0.2389976997459 | 0.54160333276586 |
| Q7Z5L7 | Q7Z5L7 | PODN_HUMAN | Podocan | PODN | negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285] | collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular space [GO:0005615] | collagen binding [GO:0005518] | 5263.426982463765 | 0.38695659220504 | 0.239219366804261 | 0.54160333276586 |
| P61353 | P61353 | RL27_HUMAN | Large ribosomal subunit protein eL27 (60S ribosomal protein L27) | RPL27 | cytoplasmic translation [GO:0002181]; response to aldosterone [GO:1904044]; rRNA processing [GO:0006364]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytoplasmic side of rough endoplasmic reticulum membrane [GO:0098556]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; synapse [GO:0045202] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 327855.029534264 | 0.249952714601403 | 0.239257525928865 | 0.54160333276586 |
| O60637 | O60637 | TSN3_HUMAN | Tetraspanin-3 (Tspan-3) (Tetraspanin TM4-A) (Transmembrane 4 superfamily member 8) | TSPAN3 | extracellular exosome [GO:0070062]; membrane [GO:0016020] | 10552.40066875905 | 0.581149780669794 | 0.239154748088544 | 0.54160333276586 | ||
| Q15796 | Q15796 | SMAD2_HUMAN | Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2) | SMAD2 | activin receptor signaling pathway [GO:0032924]; adrenal gland development [GO:0030325]; anatomical structure morphogenesis [GO:0009653]; anterior/posterior pattern specification [GO:0009952]; aortic valve morphogenesis [GO:0003180]; cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; cell population proliferation [GO:0008283]; cellular response to glucose stimulus [GO:0071333]; determination of left/right asymmetry in lateral mesoderm [GO:0003140]; DNA-templated transcription [GO:0006351]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic foregut morphogenesis [GO:0048617]; endocardial cushion morphogenesis [GO:0003203]; endoderm formation [GO:0001706]; gastrulation [GO:0007369]; in utero embryonic development [GO:0001701]; insulin secretion [GO:0030073]; intracellular signal transduction [GO:0035556]; lung development [GO:0030324]; mesoderm formation [GO:0001707]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; nodal signaling pathway [GO:0038092]; odontoblast differentiation [GO:0071895]; organ growth [GO:0035265]; pancreas development [GO:0031016]; paraxial mesoderm morphogenesis [GO:0048340]; pericardium development [GO:0060039]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; primary miRNA processing [GO:0031053]; pulmonary valve morphogenesis [GO:0003184]; regulation of binding [GO:0051098]; regulation of DNA-templated transcription [GO:0006355]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to cholesterol [GO:0070723]; secondary palate development [GO:0062009]; signal transduction involved in regulation of gene expression [GO:0023019]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]; zygotic specification of dorsal/ventral axis [GO:0007352] | activin responsive factor complex [GO:0032444]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heteromeric SMAD protein complex [GO:0071144]; homomeric SMAD protein complex [GO:0071142]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SMAD protein complex [GO:0071141]; transcription regulator complex [GO:0005667] | chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; co-SMAD binding [GO:0070410]; disordered domain specific binding [GO:0097718]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; I-SMAD binding [GO:0070411]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; phosphatase binding [GO:0019902]; R-SMAD binding [GO:0070412]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SMAD binding [GO:0046332]; tau protein binding [GO:0048156]; transforming growth factor beta receptor binding [GO:0005160]; type I transforming growth factor beta receptor binding [GO:0034713]; ubiquitin protein ligase binding [GO:0031625] | 6237.68563472649 | 0.420117835431923 | 0.239595798156221 | 0.542090776657027 |
| P08621 | P08621 | RU17_HUMAN | U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70) | SNRNP70 | mRNA splicing, via spliceosome [GO:0000398]; negative regulation of chaperone-mediated autophagy [GO:1904715]; negative regulation of protein refolding [GO:0061084]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of ATP-dependent activity [GO:0043462]; regulation of RNA splicing [GO:0043484] | nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004] | mRNA binding [GO:0003729]; RNA binding [GO:0003723]; U1 snRNA binding [GO:0030619] | 25414.19008463995 | 0.138710706248901 | 0.239759881098219 | 0.542090776657027 |
| Q9BV86 | Q9BV86 | NTM1A_HUMAN | N-terminal Xaa-Pro-Lys N-methyltransferase 1 (EC 2.1.1.244) (Alpha N-terminal protein methyltransferase 1A) (Methyltransferase-like protein 11A) (N-terminal RCC1 methyltransferase) (X-Pro-Lys N-terminal protein methyltransferase 1A) (NTM1A) [Cleaved into: N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed] | NTMT1 | chromosome segregation [GO:0007059]; N-terminal peptidyl-glycine methylation [GO:0018013]; N-terminal peptidyl-proline dimethylation [GO:0018016]; N-terminal peptidyl-serine dimethylation [GO:0035572]; N-terminal peptidyl-serine trimethylation [GO:0035573]; spindle organization [GO:0007051] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | histone methyltransferase activity [GO:0042054]; N-terminal protein N-methyltransferase activity [GO:0071885]; protein methyltransferase activity [GO:0008276] | 7050.257536128554 | 0.41366611413522 | 0.240214551835249 | 0.54290213430336 |
| Q9Y3A2 | Q9Y3A2 | UTP11_HUMAN | Probable U3 small nucleolar RNA-associated protein 11 (U3 snoRNA-associated protein 11) (UTP11-like protein) | UTP11 | nervous system development [GO:0007399]; positive regulation of apoptotic process [GO:0043065]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364] | cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] | RNA binding [GO:0003723] | 5169.9578433376 | 0.308386090184233 | 0.240599817038681 | 0.543556045989301 |
| Q03426 | Q03426 | KIME_HUMAN | Mevalonate kinase (MK) (EC 2.7.1.36) | MVK | cholesterol biosynthetic process [GO:0006695]; ergosterol biosynthetic process [GO:0006696]; isopentenyl diphosphate biosynthetic process, mevalonate pathway [GO:0019287]; isoprenoid biosynthetic process [GO:0008299]; negative regulation of inflammatory response [GO:0050728]; phosphorylation [GO:0016310] | cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisome [GO:0005777] | ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; mevalonate kinase activity [GO:0004496] | 10636.126410806875 | -0.812882131597081 | 0.241220334064546 | 0.544306815137282 |
| P62266 | P62266 | RS23_HUMAN | Small ribosomal subunit protein uS12 (40S ribosomal protein S23) | RPS23 | cytoplasmic translation [GO:0002181]; maintenance of translational fidelity [GO:1990145]; ribosomal small subunit biogenesis [GO:0042274]; stress granule assembly [GO:0034063]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribosome [GO:0005840]; rough endoplasmic reticulum [GO:0005791]; small-subunit processome [GO:0032040]; synapse [GO:0045202] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 314997.45218275755 | 0.284433977161453 | 0.241922685707307 | 0.545674338064333 |
| Q9GZT4 | Q9GZT4 | SRR_HUMAN | Serine racemase (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (EC 4.3.1.18) (L-serine ammonia-lyase) (L-serine dehydratase) (EC 4.3.1.17) | SRR | D-serine biosynthetic process [GO:0070179]; D-serine metabolic process [GO:0070178]; L-serine metabolic process [GO:0006563]; pyruvate biosynthetic process [GO:0042866]; response to lipopolysaccharide [GO:0032496]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410]; serine family amino acid metabolic process [GO:0009069] | apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuronal cell body [GO:0043025] | ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; D-serine ammonia-lyase activity [GO:0008721]; glycine binding [GO:0016594]; identical protein binding [GO:0042802]; L-serine ammonia-lyase activity [GO:0003941]; magnesium ion binding [GO:0000287]; PDZ domain binding [GO:0030165]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; serine racemase activity [GO:0030378]; threonine racemase activity [GO:0018114] | 21038.95391727615 | -0.202809741837634 | 0.242743432415415 | 0.547090011163778 |
| P53701 | P53701 | CCHL_HUMAN | Holocytochrome c-type synthase (EC 4.4.1.17) (Cytochrome c-type heme lyase) | HCCS | animal organ morphogenesis [GO:0009887]; cytochrome c-heme linkage [GO:0018063] | cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] | heme binding [GO:0020037]; holocytochrome-c synthase activity [GO:0004408]; metal ion binding [GO:0046872] | 19662.3294325096 | 0.336868162049572 | 0.243102106959668 | 0.547680532021264 |
| Q8IXI1 | Q8IXI1 | MIRO2_HUMAN | Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2) | RHOT2 | actin filament organization [GO:0007015]; cellular homeostasis [GO:0019725]; mitochondrial outer membrane permeabilization [GO:0097345]; mitochondrion organization [GO:0007005]; mitochondrion transport along microtubule [GO:0047497]; signal transduction [GO:0007165]; small GTPase-mediated signal transduction [GO:0007264] | membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] | calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] | 10264.564052316651 | -0.216033722577663 | 0.243982521945682 | 0.54922724248877 |
| Q13164 | Q13164 | MK07_HUMAN | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | MAPK7 | adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; calcineurin-NFAT signaling cascade [GO:0033173]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to transforming growth factor beta stimulus [GO:0071560]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of inflammatory response [GO:0050728]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of response to cytokine stimulus [GO:0060761]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; phosphorylation [GO:0016310]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of angiogenesis [GO:0045765]; signal transduction [GO:0007165] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] | ATP binding [GO:0005524]; enzyme inhibitor activity [GO:0004857]; MAP kinase activity [GO:0004707]; mitogen-activated protein kinase binding [GO:0051019]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | 8063.019271969125 | 0.224922883389444 | 0.244822669795959 | 0.550899621550398 |
| Q6PL24 | Q6PL24 | TMED8_HUMAN | Protein TMED8 | TMED8 | 17960.69208210455 | 0.164883775309583 | 0.245465147267783 | 0.551922267590015 | |||
| P55285 | P55285 | CADH6_HUMAN | Cadherin-6 (Kidney cadherin) (K-cadherin) | CDH6 | adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; Notch signaling pathway [GO:0007219]; synaptic membrane adhesion [GO:0099560] | adherens junction [GO:0005912]; catenin complex [GO:0016342]; cell junction [GO:0030054]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] | cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] | 19005.403592892202 | -0.247150252066524 | 0.246014658810728 | 0.552923068949457 |
| O00399 | O00399 | DCTN6_HUMAN | Dynactin subunit 6 (Dynactin subunit p27) (Protein WS-3) | DCTN6 | mitotic spindle organization [GO:0007052] | centrosome [GO:0005813]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; kinetochore [GO:0000776] | dynein complex binding [GO:0070840] | 21628.54581316395 | 0.155571217631448 | 0.246629002781342 | 0.553324598913923 |
| O75821 | O75821 | EIF3G_HUMAN | Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44) | EIF3G | formation of cytoplasmic translation initiation complex [GO:0001732]; translational initiation [GO:0006413]; viral translational termination-reinitiation [GO:0075525] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; perinuclear region of cytoplasm [GO:0048471] | RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] | 42328.432498037306 | 0.233798130222789 | 0.246624221645253 | 0.553324598913923 |
| Q9Y5Q0 | Q9Y5Q0 | FADS3_HUMAN | Fatty acid desaturase 3 (FADS3) (EC 1.14.19.-) (Delta(13) fatty acid desaturase) (Delta(13) desaturase) | FADS3 | lipid metabolic process [GO:0006629]; sphingolipid metabolic process [GO:0006665]; unsaturated fatty acid biosynthetic process [GO:0006636] | endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [GO:0016717] | 3313.19290119818 | -0.476716475664255 | 0.246353953292224 | 0.553324598913923 |
| Q12769 | Q12769 | NU160_HUMAN | Nuclear pore complex protein Nup160 (160 kDa nucleoporin) (Nucleoporin Nup160) | NUP160 | mRNA export from nucleus [GO:0006406]; nephron development [GO:0072006]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031] | cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080] | structural constituent of nuclear pore [GO:0017056] | 4497.824982679371 | -0.456338111652181 | 0.246875803959859 | 0.553324598913923 |
| Q96G03 | Q96G03 | PGM2_HUMAN | Phosphopentomutase (EC 5.4.2.7) (Glucose phosphomutase 2) (Phosphodeoxyribomutase) (Phosphoglucomutase-2) (EC 5.4.2.2) | PGM2 | glucose metabolic process [GO:0006006]; glycogen biosynthetic process [GO:0005978]; glycogen catabolic process [GO:0005980]; purine ribonucleoside salvage [GO:0006166] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774] | magnesium ion binding [GO:0000287]; phosphoglucomutase activity [GO:0004614]; phosphopentomutase activity [GO:0008973] | 36131.8859428134 | 0.169500380359647 | 0.246791970304869 | 0.553324598913923 |
| Q8IXT5 | Q8IXT5 | RB12B_HUMAN | RNA-binding protein 12B (RNA-binding motif protein 12B) | RBM12B | regulation of RNA splicing [GO:0043484] | nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904] | RNA binding [GO:0003723] | 5763.590758957866 | 0.207343139729989 | 0.24687691246989 | 0.553324598913923 |
| Q9Y2X7 | Q9Y2X7 | GIT1_HUMAN | ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) | GIT1 | brain development [GO:0007420]; cell redox homeostasis [GO:0045454]; cellular response to lipopolysaccharide [GO:0071222]; ephrin receptor signaling pathway [GO:0048013]; intramembranous ossification [GO:0001957]; locomotory behavior [GO:0007626]; motor learning [GO:0061743]; negative regulation of glycolytic process [GO:0045820]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of interleukin-1 beta production [GO:0032691]; neuron development [GO:0048666]; positive regulation of microtubule nucleation [GO:0090063]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of ARF protein signal transduction [GO:0032012]; regulation of cytokinesis [GO:0032465]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of synaptic vesicle exocytosis [GO:2000300]; synaptic vesicle recycling [GO:0036465] | calyx of Held [GO:0044305]; centrosome [GO:0005813]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; membrane [GO:0016020]; mitochondrion [GO:0005739]; mitotic spindle pole [GO:0097431]; neuron projection [GO:0043005]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; synapse [GO:0045202] | gamma-tubulin binding [GO:0043015]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; small GTPase binding [GO:0031267] | 8827.36484390658 | 0.223618470093908 | 0.247092321070285 | 0.553369601258591 |
| Q9BRK5 | Q9BRK5 | CAB45_HUMAN | 45 kDa calcium-binding protein (Cab45) (Stromal cell-derived factor 4) (SDF-4) | SDF4 | calcium-ion regulated exocytosis [GO:0017156]; cerebellum development [GO:0021549]; fat cell differentiation [GO:0045444]; maintenance of synapse structure [GO:0099558]; response to ethanol [GO:0045471]; UV protection [GO:0009650]; zymogen granule exocytosis [GO:0070625] | bleb [GO:0032059]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi lumen [GO:0005796]; late endosome [GO:0005770]; membrane [GO:0016020]; plasma membrane [GO:0005886] | calcium ion binding [GO:0005509]; identical protein binding [GO:0042802] | 80944.0444915805 | 0.247891502430823 | 0.247082338564143 | 0.553369601258591 |
| Q5T8P6 | Q5T8P6 | RBM26_HUMAN | RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26) | RBM26 | mRNA processing [GO:0006397] | nucleus [GO:0005634] | metal ion binding [GO:0046872]; RNA binding [GO:0003723] | 9856.732162271044 | -0.111141590949219 | 0.247414440811217 | 0.553434749955134 |
| P26447 | P26447 | S10A4_HUMAN | Protein S100-A4 (Calvasculin) (Metastasin) (Placental calcium-binding protein) (Protein Mts1) (S100 calcium-binding protein A4) | S100A4 | epithelial to mesenchymal transition [GO:0001837]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123] | collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] | actin binding [GO:0003779]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; chemoattractant activity [GO:0042056]; identical protein binding [GO:0042802]; RAGE receptor binding [GO:0050786]; RNA binding [GO:0003723]; transition metal ion binding [GO:0046914] | 54761.38291631405 | -0.352551873057282 | 0.24726401384442 | 0.553434749955134 |
| Q9Y6W5 | Q9Y6W5 | WASF2_HUMAN | Actin-binding protein WASF2 (Protein WAVE-2) (Verprolin homology domain-containing protein 2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2) | WASF2 | actin cytoskeleton organization [GO:0030036]; actin filament-based movement [GO:0030048]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; ameboidal-type cell migration [GO:0001667]; angiogenesis [GO:0001525]; endocytosis [GO:0006897]; lamellipodium assembly [GO:0030032]; lamellipodium morphogenesis [GO:0072673]; megakaryocyte development [GO:0035855]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of lamellipodium assembly [GO:0010592]; postsynaptic actin cytoskeleton organization [GO:0098974]; Rac protein signal transduction [GO:0016601] | actin cytoskeleton [GO:0015629]; basolateral plasma membrane [GO:0016323]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; protein-containing complex [GO:0032991]; ruffle [GO:0001726]; SCAR complex [GO:0031209]; synapse [GO:0045202] | actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; cadherin binding [GO:0045296]; protein kinase A binding [GO:0051018]; protein kinase A regulatory subunit binding [GO:0034237]; SH3 domain binding [GO:0017124] | 33998.10457315045 | 0.181204248303973 | 0.247395666711091 | 0.553434749955134 |
| Q8TD30 | Q8TD30 | ALAT2_HUMAN | Alanine aminotransferase 2 (ALT2) (EC 2.6.1.2) (Glutamate pyruvate transaminase 2) (GPT 2) (Glutamic--alanine transaminase 2) (Glutamic--pyruvic transaminase 2) | GPT2 | 2-oxoglutarate metabolic process [GO:0006103]; biosynthetic process [GO:0009058]; L-alanine catabolic process [GO:0042853]; L-alanine metabolic process [GO:0042851] | mitochondrial matrix [GO:0005759] | L-alanine:2-oxoglutarate aminotransferase activity [GO:0004021]; pyridoxal phosphate binding [GO:0030170] | 5536.823964978545 | -0.348800577431812 | 0.247825547327193 | 0.554135576620315 |
| Q00587 | Q00587 | BORG5_HUMAN | Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) | CDC42EP1 | positive regulation of actin filament polymerization [GO:0030838]; positive regulation of pseudopodium assembly [GO:0031274]; regulation of cell shape [GO:0008360]; Rho protein signal transduction [GO:0007266] | adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886] | cadherin binding involved in cell-cell adhesion [GO:0098641]; small GTPase binding [GO:0031267] | 20848.60175109595 | -0.124789428963263 | 0.248632658547644 | 0.555720963838639 |
| Q9ULF5 | Q9ULF5 | S39AA_HUMAN | Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10) | SLC39A10 | epithelial to mesenchymal transition [GO:0001837]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of B cell apoptotic process [GO:0002903]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of B cell receptor signaling pathway [GO:0050861]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577] | apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886] | monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385] | 8226.39649384569 | 0.193798858930266 | 0.249314101971017 | 0.557024330350071 |
| Q8N129 | Q8N129 | CNPY4_HUMAN | Protein canopy homolog 4 | CNPY4 | positive regulation of protein localization to plasma membrane [GO:1903078] | extracellular region [GO:0005576] | signaling receptor binding [GO:0005102] | 24675.23377477425 | 0.277564161178894 | 0.24957856960167 | 0.557395417959425 |
| Q9UJJ9 | Q9UJJ9 | GNPTG_HUMAN | N-acetylglucosamine-1-phosphotransferase subunit gamma (GlcNAc-1-phosphotransferase subunit gamma) (UDP-N-acetylglucosamine-1-phosphotransferase subunit gamma) | GNPTG | carbohydrate phosphorylation [GO:0046835]; N-glycan processing to lysosome [GO:0016256] | extracellular exosome [GO:0070062]; glucosidase II complex [GO:0017177]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex [GO:0070622] | protein homodimerization activity [GO:0042803]; UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity [GO:0003976] | 4329.3970155375955 | 0.516656097405254 | 0.249970469950837 | 0.558050702419796 |
| Q9HD67 | Q9HD67 | MYO10_HUMAN | Unconventional myosin-X (Unconventional myosin-10) | MYO10 | cytoskeleton-dependent intracellular transport [GO:0030705]; positive regulation of cell-cell adhesion [GO:0022409]; regulation of cell shape [GO:0008360]; regulation of filopodium assembly [GO:0051489]; signal transduction [GO:0007165] | cell cortex [GO:0005938]; cytosol [GO:0005829]; filopodium [GO:0030175]; filopodium membrane [GO:0031527]; filopodium tip [GO:0032433]; lamellipodium [GO:0030027]; myosin complex [GO:0016459]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; ruffle [GO:0001726] | actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; plus-end directed microfilament motor activity [GO:0060002]; spectrin binding [GO:0030507] | 4612.261472179 | 0.49743094523028 | 0.251745803830808 | 0.561571545080849 |
| Q92685 | Q92685 | ALG3_HUMAN | Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (EC 2.4.1.258) (Asparagine-linked glycosylation protein 3 homolog) (Dol-P-Man-dependent alpha(1-3)-mannosyltransferase) (Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase) (Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase) (Not56-like protein) | ALG3 | dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein glycosylation [GO:0006486] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] | alpha-1,3-mannosyltransferase activity [GO:0000033]; dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity [GO:0052925] | 26307.2000215272 | -0.493529067284951 | 0.251976488579542 | 0.561864928882994 |
| Q86XA9 | Q86XA9 | HTR5A_HUMAN | HEAT repeat-containing protein 5A | HEATR5A | endocytosis [GO:0006897]; protein localization [GO:0008104]; retrograde transport, endosome to Golgi [GO:0042147] | cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] | 5560.630663719816 | -0.167814818669375 | 0.252143517506639 | 0.561940084111422 | |
| Q14690 | Q14690 | RRP5_HUMAN | Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11) | PDCD11 | rRNA processing [GO:0006364] | cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040] | NF-kappaB binding [GO:0051059]; RNA binding [GO:0003723] | 7122.219275031621 | -0.309793133413592 | 0.252307725728814 | 0.561940084111422 |
| Q2TAA5 | Q2TAA5 | ALG11_HUMAN | GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC 2.4.1.131) (Asparagine-linked glycosylation protein 11 homolog) (Glycolipid 2-alpha-mannosyltransferase) | ALG11 | oligosaccharide-lipid intermediate biosynthetic process [GO:0006490]; protein N-linked glycosylation [GO:0006487] | endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] | alpha-1,2-mannosyltransferase activity [GO:0000026]; GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity [GO:0004377] | 5372.210076547601 | -0.619397966548756 | 0.252650505708316 | 0.562482422531757 |
| Q9NY93 | Q9NY93 | DDX56_HUMAN | Probable ATP-dependent RNA helicase DDX56 (EC 3.6.4.13) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD box protein 21) (DEAD box protein 56) | DDX56 | defense response to virus [GO:0051607]; modulation by host of viral RNA genome replication [GO:0044830]; negative regulation of type I interferon production [GO:0032480]; positive regulation of neuron projection development [GO:0010976]; rRNA processing [GO:0006364] | cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA stem-loop binding [GO:0035613] | 2590.591853613875 | -0.179849000636999 | 0.252915865685469 | 0.56263105417113 |
| Q13057 | Q13057 | COASY_HUMAN | Bifunctional coenzyme A synthase (CoA synthase) (NBP) (POV-2) [Includes: Phosphopantetheine adenylyltransferase (EC 2.7.7.3) (Dephospho-CoA pyrophosphorylase) (Pantetheine-phosphate adenylyltransferase) (PPAT); Dephospho-CoA kinase (DPCK) (EC 2.7.1.24) (Dephosphocoenzyme A kinase) (DPCOAK)] | COASY | coenzyme A biosynthetic process [GO:0015937]; phosphorylation [GO:0016310] | extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741] | ATP binding [GO:0005524]; dephospho-CoA kinase activity [GO:0004140]; pantetheine-phosphate adenylyltransferase activity [GO:0004595] | 11179.356299004849 | -0.216865951674927 | 0.25368859506492 | 0.563751498567545 |
| Q9NZN4 | Q9NZN4 | EHD2_HUMAN | EH domain-containing protein 2 (PAST homolog 2) | EHD2 | cilium assembly [GO:0060271]; cortical actin cytoskeleton organization [GO:0030866]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; plasma membrane tubulation [GO:0097320]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of myoblast fusion [GO:1901741]; protein localization to plasma membrane [GO:0072659] | caveola [GO:0005901]; clathrin coat of coated pit [GO:0030132]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] | ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; protein domain specific binding [GO:0019904] | 85993.7122849365 | 0.146441853894958 | 0.253911057749613 | 0.563751498567545 |
| Q8TD19 | Q8TD19 | NEK9_HUMAN | Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) | NEK9 | cell division [GO:0051301]; mitotic cell cycle [GO:0000278]; phosphorylation [GO:0016310]; regulation of mitotic cell cycle [GO:0007346] | centrosome [GO:0005813]; cytosol [GO:0005829]; nucleus [GO:0005634] | ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | 14664.77253004575 | -0.132455793564344 | 0.253689251309987 | 0.563751498567545 |
| Q9Y4C2 | Q9Y4C2 | TCAF1_HUMAN | TRPM8 channel-associated factor 1 (TRP channel-associated factor 1) | TCAF1 | negative regulation of cell migration [GO:0030336]; positive regulation of anion channel activity [GO:1901529]; positive regulation of protein targeting to membrane [GO:0090314] | plasma membrane [GO:0005886] | transmembrane transporter binding [GO:0044325] | 13357.171107601851 | -0.492392130491695 | 0.253917018062897 | 0.563751498567545 |
| P23193 | P23193 | TCEA1_HUMAN | Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o) | TCEA1 | DNA-templated transcription [GO:0006351]; positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368] | nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669] | DNA binding [GO:0003677]; zinc ion binding [GO:0008270] | 18408.57977294355 | -0.148723296665535 | 0.253882101797468 | 0.563751498567545 |
| P20042 | P20042 | IF2B_HUMAN | Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF2-beta) | EIF2S2 | cytoplasmic translational initiation [GO:0002183]; formation of cytoplasmic translation initiation complex [GO:0001732]; formation of translation preinitiation complex [GO:0001731]; in utero embryonic development [GO:0001701]; male germ cell proliferation [GO:0002176]; male gonad development [GO:0008584]; translational initiation [GO:0006413] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2 complex [GO:0005850]; synapse [GO:0045202] | metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369] | 72568.70615753994 | 0.17869150338791 | 0.25402226735286 | 0.563764264324835 |
| P30419 | P30419 | NMT1_HUMAN | Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 1) (HsNMT1) (NMT 1) (Type I N-myristoyltransferase) (Peptide N-myristoyltransferase 1) (Protein-lysine myristoyltransferase NMT1) (EC 2.3.1.-) | NMT1 | cellular ketone metabolic process [GO:0042180]; in utero embryonic development [GO:0001701]; N-terminal peptidyl-glycine N-myristoylation [GO:0018008]; protein localization to membrane [GO:0072657]; regulation of rhodopsin mediated signaling pathway [GO:0022400] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] | glycylpeptide N-tetradecanoyltransferase activity [GO:0004379]; myristoyltransferase activity [GO:0019107]; peptidyl-lysine N6-myristoyltransferase activity [GO:0018030] | 28063.3361844182 | 0.0785485776632747 | 0.254769479102898 | 0.564758947025438 |
| Q8WXA9 | Q8WXA9 | SREK1_HUMAN | Splicing regulatory glutamine/lysine-rich protein 1 (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12) (Splicing regulatory protein 508) (SRrp508) | SREK1 | mRNA processing [GO:0006397]; RNA splicing [GO:0008380] | nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681] | RNA binding [GO:0003723] | 3207.3712348149747 | -1.05240345347266 | 0.25472180412487 | 0.564758947025438 |
| O00401 | O00401 | WASL_HUMAN | Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP) | WASL | actin filament polymerization [GO:0030041]; actin polymerization or depolymerization [GO:0008154]; cell division [GO:0051301]; dendritic spine morphogenesis [GO:0060997]; negative regulation of lymphocyte migration [GO:2000402]; negative regulation of membrane tubulation [GO:1903526]; positive regulation of clathrin-dependent endocytosis [GO:2000370]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; protein-containing complex localization [GO:0031503]; regulation of postsynapse organization [GO:0099175]; regulation of protein localization [GO:0032880]; response to bacterium [GO:0009617]; spindle localization [GO:0051653]; vesicle budding from membrane [GO:0006900]; vesicle organization [GO:0016050]; vesicle transport along actin filament [GO:0030050] | actin cap [GO:0030478]; actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | actin binding [GO:0003779]; GTPase regulator activity [GO:0030695]; microtubule binding [GO:0008017] | 5259.081707694615 | 0.351872708705198 | 0.254984631864468 | 0.565014831499443 |
| Q9NRG9 | Q9NRG9 | AAAS_HUMAN | Aladin (Adracalin) | AAAS | fertilization [GO:0009566]; learning [GO:0007612]; microtubule bundle formation [GO:0001578]; mitotic spindle assembly [GO:0090307]; mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031]; regulation of nucleocytoplasmic transport [GO:0046822] | centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; mitotic spindle [GO:0072686]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922] | 4970.527375772765 | -0.207558945117969 | 0.255903422788285 | 0.566386247468135 | |
| Q9Y6G9 | Q9Y6G9 | DC1L1_HUMAN | Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic) (DLIC-1) | DYNC1LI1 | cell cycle [GO:0007049]; cell division [GO:0051301]; early endosome to recycling endosome transport [GO:0061502]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based movement [GO:0007018]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; regulation of vesicle-mediated transport [GO:0060627] | centrosome [GO:0005813]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; ficolin-1-rich granule membrane [GO:0101003]; kinetochore [GO:0000776]; membrane [GO:0016020]; microtubule [GO:0005874]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; secretory granule membrane [GO:0030667]; spindle pole [GO:0000922] | ATP binding [GO:0005524]; dynein heavy chain binding [GO:0045504]; GDP binding [GO:0019003]; molecular adaptor activity [GO:0060090]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723] | 34698.30795670775 | 0.153716806172462 | 0.256459831334725 | 0.567396096970931 |
| Q8TAD8 | Q8TAD8 | SNIP1_HUMAN | Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1) | SNIP1 | maintenance of RNA location [GO:0051237]; miRNA processing [GO:0035196]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of protein dephosphorylation [GO:0035308]; U2-type prespliceosome assembly [GO:1903241] | cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005] | mRNA binding [GO:0003729]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; RNA binding [GO:0003723]; transcription regulator inhibitor activity [GO:0140416] | 4306.91416204118 | 0.215952340939373 | 0.257728847849837 | 0.569758740506117 |
| Q13325 | Q13325 | IFIT5_HUMAN | Interferon-induced protein with tetratricopeptide repeats 5 (IFIT-5) (Interferon-induced 58 kDa protein) (Retinoic acid- and interferon-inducible 58 kDa protein) (P58) | IFIT5 | defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123] | actin cytoskeleton [GO:0015629]; apical part of cell [GO:0045177]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] | double-stranded DNA binding [GO:0003690]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; single-stranded RNA binding [GO:0003727]; tRNA binding [GO:0000049] | 7422.533173486675 | 0.243430612378595 | 0.258089039248383 | 0.570311040859649 |
| Q86SJ2 | Q86SJ2 | AMGO2_HUMAN | Amphoterin-induced protein 2 (AMIGO-2) (Alivin-1) (Differentially expressed in gastric adenocarcinomas) (DEGA) | AMIGO2 | brain development [GO:0007420]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of programmed cell death [GO:0043069]; positive regulation of synapse assembly [GO:0051965] | nucleus [GO:0005634]; plasma membrane [GO:0005886] | 2528.937762079865 | -1.59257275850401 | 0.258335606147352 | 0.570396047536153 | |
| Q9BV94 | Q9BV94 | EDEM2_HUMAN | ER degradation-enhancing alpha-mannosidase-like protein 2 | EDEM2 | carbohydrate metabolic process [GO:0005975]; ERAD pathway [GO:0036503]; mannoprotein catabolic process [GO:0006058]; positive regulation of retrograde protein transport, ER to cytosol [GO:1904154]; response to unfolded protein [GO:0006986]; viral protein processing [GO:0019082] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum quality control compartment [GO:0044322]; membrane [GO:0016020] | calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571] | 6611.91449904746 | 0.710859903061472 | 0.258419811864685 | 0.570396047536153 |
| P32455 | P32455 | GBP1_HUMAN | Guanylate-binding protein 1 (EC 3.6.1.-) (EC 3.6.5.-) (GTP-binding protein 1) (GBP-1) (HuGBP-1) (hGBP1) (Guanine nucleotide-binding protein 1) (Interferon-induced guanylate-binding protein 1) | GBP1 | cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; cytolysis in another organism [GO:0051715]; defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; negative regulation of T cell receptor signaling pathway [GO:0050860]; non-canonical inflammasome complex assembly [GO:0160075]; positive regulation of pyroptosis [GO:0140639]; protein localization to vacuole [GO:0072665]; regulation of calcium-mediated signaling [GO:0050848]; regulation of protein localization to plasma membrane [GO:1903076] | actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; symbiont cell surface [GO:0106139]; vesicle membrane [GO:0012506] | actin binding [GO:0003779]; cytokine binding [GO:0019955]; enzyme binding [GO:0019899]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GDP phosphatase activity [GO:0004382]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; protein homodimerization activity [GO:0042803]; spectrin binding [GO:0030507] | 10626.4468599429 | 0.248202548867762 | 0.259152918077487 | 0.571568872645793 |
| O43704 | O43704 | ST1B1_HUMAN | Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase) | SULT1B1 | 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; biogenic amine metabolic process [GO:0006576]; epithelial cell differentiation [GO:0030855]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; phenol-containing compound metabolic process [GO:0018958]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805] | cytoplasm [GO:0005737]; cytosol [GO:0005829] | aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146] | 38119.2778263187 | -0.184326531631887 | 0.259842111393166 | 0.572643097298202 |
| Q92665 | Q92665 | RT31_HUMAN | Small ribosomal subunit protein mS31 (28S ribosomal protein S31, mitochondrial) (MRP-S31) (S31mt) (Imogen 38) | MRPS31 | mitochondrial translation [GO:0032543] | mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleolus [GO:0005730] | protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 7814.33662136164 | 0.415103694597545 | 0.26064014687594 | 0.573955333151604 |
| Q6UXH1 | Q6UXH1 | CREL2_HUMAN | Protein disulfide isomerase CRELD2 (EC 5.3.4.1) (Cysteine-rich with EGF-like domain protein 2) | CRELD2 | endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794] | calcium ion binding [GO:0005509]; protein disulfide isomerase activity [GO:0003756] | 267010.44748580654 | 0.291345693707397 | 0.261749255368537 | 0.576173768810463 | |
| Q9HC35 | Q9HC35 | EMAL4_HUMAN | Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) | EML4 | attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]; mitotic metaphase chromosome alignment [GO:0007080] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; mitotic spindle [GO:0072686] | alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; microtubule binding [GO:0008017]; protein self-association [GO:0043621] | 13772.6940860287 | -0.10403151438263 | 0.263042377016857 | 0.57879538181651 |
| Q92945 | Q92945 | FUBP2_HUMAN | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | KHSRP | 3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to cytokine stimulus [GO:0071345]; miRNA metabolic process [GO:0010586]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; positive regulation of mRNA catabolic process [GO:0061014]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of mRNA stability [GO:0043488]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | DNA binding [GO:0003677]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA binding [GO:0003729]; protein folding chaperone [GO:0044183]; RNA binding [GO:0003723] | 59569.739496919196 | -0.0699257291393786 | 0.263664957642652 | 0.579940081523007 |
| Q9BYX2 | Q9BYX2 | TBD2A_HUMAN | TBC1 domain family member 2A (Armus) (Prostate antigen recognized and identified by SEREX 1) (PARIS-1) | TBC1D2 | positive regulation of GTPase activity [GO:0043547] | anchoring junction [GO:0070161]; cell junction [GO:0030054]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] | cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096] | 5888.434720651325 | -0.39450108758797 | 0.263895449035439 | 0.580221813828015 |
| P29353 | P29353 | SHC1_HUMAN | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) | SHC1 | actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; cell-cell adhesion [GO:0098609]; cellular response to growth factor stimulus [GO:0071363]; defense response to bacterium [GO:0042742]; epidermal growth factor receptor signaling pathway [GO:0007173]; heart development [GO:0007507]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular signal transduction [GO:0035556]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell proliferation in bone marrow [GO:0071864]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of MAPK cascade [GO:0043410]; regulation of superoxide metabolic process [GO:0090322] | cytosol [GO:0005829]; focal adhesion [GO:0005925]; mitochondrial matrix [GO:0005759]; plasma membrane [GO:0005886]; Shc-EGFR complex [GO:0070435] | ephrin receptor binding [GO:0046875]; epidermal growth factor binding [GO:0048408]; epidermal growth factor receptor binding [GO:0005154]; insulin receptor binding [GO:0005158]; insulin-like growth factor receptor binding [GO:0005159]; neurotrophin TRKA receptor binding [GO:0005168]; phospholipid binding [GO:0005543]; phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] | 21505.49531371805 | 0.110649344787968 | 0.264185310191482 | 0.580524132191341 |
| P82933 | P82933 | RT09_HUMAN | Small ribosomal subunit protein uS9m (28S ribosomal protein S9, mitochondrial) (MRP-S9) (S9mt) | MRPS9 | mitochondrial translation [GO:0032543] | mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleolus [GO:0005730] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 4971.1897143644255 | 0.236692701238901 | 0.264468205918746 | 0.580804982455664 |
| Q9BZI7 | Q9BZI7 | REN3B_HUMAN | Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X) | UPF3B | brain development [GO:0007420]; mRNA transport [GO:0051028]; neuron projection development [GO:0031175]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of mRNA cis splicing, via spliceosome [GO:1905746]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of translation [GO:0045727] | centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | mRNA binding [GO:0003729]; RNA binding [GO:0003723] | 6686.540678624225 | 0.265496267368606 | 0.264836996692853 | 0.581389547951068 |
| Q96RD7 | Q96RD7 | PANX1_HUMAN | Pannexin-1 (PANX1) [Cleaved into: Caspase-activated pannexin-1 (Caspase-activated PANX1)] | PANX1 | ATP transport [GO:0015867]; calcium ion transport [GO:0006816]; cell-cell signaling [GO:0007267]; monoatomic anion transmembrane transport [GO:0098656]; monoatomic cation transport [GO:0006812]; oogenesis [GO:0048477]; positive regulation of interleukin-1 alpha production [GO:0032730]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of macrophage cytokine production [GO:0060907]; response to ATP [GO:0033198]; response to ischemia [GO:0002931] | bleb [GO:0032059]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; gap junction [GO:0005921]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] | actin filament binding [GO:0051015]; ATP transmembrane transporter activity [GO:0005347]; calcium channel activity [GO:0005262]; gap junction channel activity [GO:0005243]; identical protein binding [GO:0042802]; leak channel activity [GO:0022840]; monoatomic anion channel activity [GO:0005253]; protease binding [GO:0002020]; scaffold protein binding [GO:0097110]; signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198]; transmembrane transporter binding [GO:0044325]; wide pore channel activity [GO:0022829] | 4501.502419048014 | 0.377161488125364 | 0.265722327200294 | 0.583107167279963 |
| Q9BR61 | Q9BR61 | ACBD6_HUMAN | Acyl-CoA-binding domain-containing protein 6 | ACBD6 | cytosol [GO:0005829] | fatty-acyl-CoA binding [GO:0000062] | 15858.0135690129 | 0.122360408289005 | 0.265955678241383 | 0.583393291875988 | |
| Q7Z422 | Q7Z422 | SZRD1_HUMAN | SUZ RNA-binding domain-containing (SUZ domain-containing protein 1) (Putative MAPK-activating protein PM18/PM20/PM22) | SZRD1 | 20685.376226206652 | 0.390624279608745 | 0.266103459003091 | 0.583491562968851 | |||
| P05198 | P05198 | IF2A_HUMAN | Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha) | EIF2S1 | cellular response to amino acid starvation [GO:0034198]; cellular response to heat [GO:0034605]; cellular response to oxidative stress [GO:0034599]; cellular response to UV [GO:0034644]; negative regulation of translational initiation in response to stress [GO:0032057]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of type B pancreatic cell apoptotic process [GO:2000676]; regulation of translation in response to endoplasmic reticulum stress [GO:0036490]; regulation of translational initiation in response to stress [GO:0043558]; response to endoplasmic reticulum stress [GO:0034976]; response to kainic acid [GO:1904373]; response to manganese-induced endoplasmic reticulum stress [GO:1990737]; stress granule assembly [GO:0034063]; translational initiation [GO:0006413] | cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 2 complex [GO:0005850]; extracellular exosome [GO:0070062]; glial limiting end-foot [GO:0097451]; membrane [GO:0016020]; nucleus [GO:0005634]; synapse [GO:0045202]; translation initiation ternary complex [GO:0044207] | ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] | 113130.799919642 | 0.124351780818328 | 0.266287712524482 | 0.583669701804144 |
| P84103 | P84103 | SRSF3_HUMAN | Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3) | SRSF3 | cellular response to leukemia inhibitory factor [GO:1990830]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; primary miRNA processing [GO:0031053]; regulation of mRNA splicing, via spliceosome [GO:0048024] | cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654] | phospholipase binding [GO:0043274]; primary miRNA binding [GO:0070878]; protein-RNA sequence-specific adaptor activity [GO:0160134]; RNA binding [GO:0003723] | 34549.6922418201 | 0.231480123983471 | 0.266728981485457 | 0.584410831050503 |
| Q9Y2S2 | Q9Y2S2 | CRYL1_HUMAN | Lambda-crystallin homolog (EC 1.1.1.45) (L-gulonate 3-dehydrogenase) (Gul3DH) | CRYL1 | fatty acid metabolic process [GO:0006631]; glucuronate catabolic process to xylulose 5-phosphate [GO:0019640] | cytosol [GO:0005829]; extracellular exosome [GO:0070062] | L-gulonate 3-dehydrogenase activity [GO:0050104]; NAD+ binding [GO:0070403]; protein homodimerization activity [GO:0042803] | 9529.761401953705 | -0.196619420060573 | 0.267076511922608 | 0.584946082935251 |
| Q9UKM9 | Q9UKM9 | RALY_HUMAN | RNA-binding protein Raly (Autoantigen p542) (Heterogeneous nuclear ribonucleoprotein C-like 2) (hnRNP core protein C-like 2) (hnRNP associated with lethal yellow protein homolog) | RALY | cholesterol homeostasis [GO:0042632]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of transcription by RNA polymerase II [GO:0000122] | catalytic step 2 spliceosome [GO:0071013]; nucleus [GO:0005634] | RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712] | 48215.5210242283 | 0.154146923164848 | 0.267982026394212 | 0.586702535374653 |
| Q6ICG6 | Q6ICG6 | K0930_HUMAN | Uncharacterized protein KIAA0930 | KIAA0930 | 4801.356075953835 | -0.159274261748271 | 0.269559389195283 | 0.589927964148504 | |||
| Q9UL18 | Q9UL18 | AGO1_HUMAN | Protein argonaute-1 (Argonaute1) (hAgo1) (Argonaute RISC catalytic component 1) (Eukaryotic translation initiation factor 2C 1) (eIF-2C 1) (eIF2C 1) (Putative RNA-binding protein Q99) | AGO1 | miRNA processing [GO:0035196]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; negative regulation of angiogenesis [GO:0016525]; nuclear-transcribed mRNA catabolic process [GO:0000956]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pre-miRNA processing [GO:0031054]; regulation of mRNA stability [GO:0043488]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; RISC complex assembly [GO:0070922]; RNA secondary structure unwinding [GO:0010501] | cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578] | core promoter sequence-specific DNA binding [GO:0001046]; double-stranded RNA binding [GO:0003725]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; RNA polymerase II complex binding [GO:0000993]; single-stranded RNA binding [GO:0003727] | 6485.75894612777 | -0.337546658128956 | 0.270212455691913 | 0.59067275229567 |
| Q13126 | Q13126 | MTAP_HUMAN | S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) (5'-methylthioadenosine phosphorylase) (MTA phosphorylase) (MTAP) (MTAPase) | MTAP | L-methionine salvage from methylthioadenosine [GO:0019509]; methylation [GO:0032259]; nucleobase-containing compound metabolic process [GO:0006139]; purine ribonucleoside salvage [GO:0006166]; response to testosterone [GO:0033574] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654] | 1,4-alpha-oligoglucan phosphorylase activity [GO:0004645]; S-methyl-5-thioadenosine phosphorylase activity [GO:0017061] | 56612.23166067375 | 0.129220186268992 | 0.270188192018283 | 0.59067275229567 |
| O15084 | O15084 | ANR28_HUMAN | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK) | ANKRD28 | negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223] | cytosol [GO:0005829]; nucleoplasm [GO:0005654] | 4003.2881883710097 | -0.335850253299368 | 0.270867998138469 | 0.591877391998675 | |
| O00400 | O00400 | ACATN_HUMAN | Acetyl-coenzyme A transporter 1 (AT-1) (Acetyl-CoA transporter 1) (Solute carrier family 33 member 1) | SLC33A1 | acetyl-CoA transmembrane transport [GO:0035348]; transmembrane transport [GO:0055085] | endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886] | acetyl-CoA transmembrane transporter activity [GO:0008521]; protein homodimerization activity [GO:0042803] | 18862.381093984448 | 0.223802359342817 | 0.271186903072857 | 0.592345795223905 |
| P62333 | P62333 | PRS10_HUMAN | 26S proteasome regulatory subunit 10B (26S proteasome AAA-ATPase subunit RPT4) (Proteasome 26S subunit ATPase 6) (Proteasome subunit p42) | PSMC6 | ERAD pathway [GO:0036503]; positive regulation of inclusion body assembly [GO:0090261]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0045899]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] | cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; extracellular exosome [GO:0070062]; inclusion body [GO:0016234]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; proteasome-activating activity [GO:0036402]; protein-macromolecule adaptor activity [GO:0030674] | 81214.19882377141 | 0.0821179034479059 | 0.271736315105909 | 0.593081579201691 |
| Q15678 | Q15678 | PTN14_HUMAN | Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) | PTPN14 | lymphangiogenesis [GO:0001946]; negative regulation of cell population proliferation [GO:0008285]; protein dephosphorylation [GO:0006470]; regulation of protein export from nucleus [GO:0046825] | cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | protein tyrosine phosphatase activity [GO:0004725]; receptor tyrosine kinase binding [GO:0030971]; transcription coregulator activity [GO:0003712] | 8302.120731689494 | 0.292990990017845 | 0.272329327546613 | 0.59369679487461 |
| P62841 | P62841 | RS15_HUMAN | Small ribosomal subunit protein uS19 (40S ribosomal protein S15) (RIG protein) | RPS15 | cytoplasmic translation [GO:0002181]; liver regeneration [GO:0097421]; osteoblast differentiation [GO:0001649]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; ribosomal small subunit export from nucleus [GO:0000056]; rRNA processing [GO:0006364]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202] | DNA binding [GO:0003677]; MDM2/MDM4 family protein binding [GO:0097371]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948] | 240459.2555923825 | 0.328310660299885 | 0.272306580816826 | 0.59369679487461 |
| P14678;P63162 | P14678 | RSMB_HUMAN | Small nuclear ribonucleoprotein-associated proteins B and B' (snRNP-B) (Sm protein B/B') (Sm-B/B') (SmB/B') | SNRPB | 7-methylguanosine cap hypermethylation [GO:0036261]; mRNA splicing, via spliceosome [GO:0000398]; protein methylation [GO:0006479]; RNA splicing [GO:0008380]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241] | catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone pre-mRNA 3'end processing complex [GO:0071204]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; telomerase holoenzyme complex [GO:0005697]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U2-type spliceosomal complex [GO:0005684]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; U7 snRNP [GO:0005683] | histone pre-mRNA DCP binding [GO:0071208]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]; U1 snRNP binding [GO:1990446]; U2 snRNP binding [GO:1990447] | 39668.636298328696 | -0.125338679716221 | 0.273632298645871 | 0.595849578834552 |
| O95429 | O95429 | BAG4_HUMAN | BAG family molecular chaperone regulator 4 (BAG-4) (Bcl-2-associated athanogene 4) (Silencer of death domains) | BAG4 | cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to tumor necrosis factor [GO:0071356]; negative regulation of apoptotic process [GO:0043066]; negative regulation of mRNA modification [GO:0090367]; negative regulation of protein targeting to mitochondrion [GO:1903215]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell adhesion [GO:0045785]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of stress fiber assembly [GO:0051496]; protein folding [GO:0006457]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; ruffle assembly [GO:0097178] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | adenyl-nucleotide exchange factor activity [GO:0000774]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625] | 7787.862469945139 | -0.21438009906047 | 0.274221312802183 | 0.59641310147348 |
| Q2KHT3 | Q2KHT3 | CL16A_HUMAN | Protein CLEC16A (C-type lectin domain family 16 member A) | CLEC16A | autophagy [GO:0006914]; cellular response to starvation [GO:0009267]; endosomal transport [GO:0016197]; endosome to lysosome transport [GO:0008333]; negative regulation of autophagosome maturation [GO:1901097]; positive regulation of TORC1 signaling [GO:1904263]; regulation of autophagosome maturation [GO:1901096] | cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; vesicle [GO:0031982] | 2553.607459358105 | 0.460796090398719 | 0.274152016794081 | 0.59641310147348 | |
| Q6GMV3 | Q6GMV3 | PTRD1_HUMAN | Putative peptidyl-tRNA hydrolase PTRHD1 (EC 3.1.1.29) (Peptidyl-tRNA hydrolase domain-containing protein 1) | PTRHD1 | aminoacyl-tRNA hydrolase activity [GO:0004045] | 13109.35573289955 | -0.162873925460338 | 0.274417394200735 | 0.59641310147348 | ||
| P06753 | P06753 | TPM3_HUMAN | Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5) | TPM3 | actin filament organization [GO:0007015]; muscle contraction [GO:0006936] | actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; muscle thin filament tropomyosin [GO:0005862]; stress fiber [GO:0001725] | actin filament binding [GO:0051015] | 148179.3926051685 | 0.291658742948603 | 0.274376673717284 | 0.59641310147348 |
| Q8TF42 | Q8TF42 | UBS3B_HUMAN | Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2) | UBASH3B | collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; negative regulation of bone resorption [GO:0045779]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of signal transduction [GO:0009968]; platelet aggregation [GO:0070527]; regulation of osteoclast differentiation [GO:0045670]; regulation of release of sequestered calcium ion into cytosol [GO:0051279] | cytoplasm [GO:0005737]; nucleus [GO:0005634] | identical protein binding [GO:0042802]; phosphoprotein binding [GO:0051219]; protein tyrosine phosphatase activity [GO:0004725]; ubiquitin protein ligase binding [GO:0031625] | 6604.64152135076 | -0.13522166797218 | 0.274379880635304 | 0.59641310147348 |
| P23508 | P23508 | CRCM_HUMAN | Colorectal mutant cancer protein (Protein MCC) | MCC | establishment of protein localization [GO:0045184]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial cell proliferation [GO:0050680]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | signaling receptor activity [GO:0038023] | 7888.49792462213 | 0.227255091989778 | 0.275114284991763 | 0.597698442777351 |
| P37108 | P37108 | SRP14_HUMAN | Signal recognition particle 14 kDa protein (SRP14) (18 kDa Alu RNA-binding protein) | SRP14 | cotranslational protein targeting to membrane [GO:0006613]; protein targeting to ER [GO:0045047]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786] | 7S RNA binding [GO:0008312]; endoplasmic reticulum signal peptide binding [GO:0030942]; RNA binding [GO:0003723] | 92402.1107248289 | -0.203027347918639 | 0.275276564852187 | 0.59782177709946 |
| Q14692 | Q14692 | BMS1_HUMAN | Ribosome biogenesis protein BMS1 homolog (Ribosome assembly protein BMS1 homolog) | BMS1 | endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000479]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274] | 90S preribosome [GO:0030686]; chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] | ATP binding [GO:0005524]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; U3 snoRNA binding [GO:0034511] | 6246.76157463471 | -0.298941639179913 | 0.276395884970064 | 0.59933374827416 |
| P53990 | P53990 | IST1_HUMAN | IST1 homolog (hIST1) (Charged multivesicular body protein 8) (CHMP8) (Putative MAPK-activating protein PM28) | IST1 | abscission [GO:0009838]; cell division [GO:0051301]; collateral sprouting [GO:0048668]; cytoskeleton-dependent cytokinesis [GO:0061640]; ESCRT III complex disassembly [GO:1904903]; establishment of protein localization [GO:0045184]; multivesicular body assembly [GO:0036258]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of proteolysis [GO:0045862]; protein localization [GO:0008104]; protein transport [GO:0015031]; viral capsid secondary envelopment [GO:0046745]; viral release from host cell [GO:0019076] | azurophil granule lumen [GO:0035578]; centrosome [GO:0005813]; chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Flemming body [GO:0090543]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; nuclear envelope [GO:0005635] | cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; MIT domain binding [GO:0090541]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877] | 25881.34486566875 | 0.188162857635388 | 0.27624639493948 | 0.59933374827416 |
| P49366 | P49366 | DHYS_HUMAN | Deoxyhypusine synthase (DHS) (EC 2.5.1.46) | DHPS | glucose homeostasis [GO:0042593]; peptidyl-lysine modification to peptidyl-hypusine [GO:0008612]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of T cell proliferation [GO:0042102]; spermidine catabolic process [GO:0046203]; spermidine metabolic process [GO:0008216]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829] | deoxyhypusine synthase activity [GO:0034038]; identical protein binding [GO:0042802] | 6145.86928520847 | 0.425901463997822 | 0.276576751816545 | 0.599496509484523 |
| P0DI83 | P0DI83 | NARR_HUMAN | Ras-related protein Rab-34, isoform NARR (Nine amino-acid residue-repeats) | RAB34 | nucleolus [GO:0005730] | 10596.321470390849 | 0.274784393919934 | 0.276909827861116 | 0.599988942509019 | ||
| Q8TBB5 | Q8TBB5 | KLDC4_HUMAN | Kelch domain-containing protein 4 | KLHDC4 | 3124.5876144461354 | 1.23057812373916 | 0.277268214721277 | 0.600354283014615 | |||
| Q9Y6M5 | Q9Y6M5 | ZNT1_HUMAN | Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1) | SLC30A1 | cadmium ion transmembrane transport [GO:0070574]; calcium ion import [GO:0070509]; defense response to bacterium [GO:0042742]; detoxification of cadmium ion [GO:0071585]; detoxification of zinc ion [GO:0010312]; in utero embryonic development [GO:0001701]; intracellular calcium ion homeostasis [GO:0006874]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of calcium ion import [GO:0090281]; negative regulation of neurotransmitter secretion [GO:0046929]; negative regulation of zinc ion transmembrane import [GO:0071584]; positive regulation of dendritic spine morphogenesis [GO:0061003]; regulation of postsynaptic density protein 95 clustering [GO:1902897]; zinc export across plasma membrane [GO:0140882]; zinc ion import into organelle [GO:0062111]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829] | basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; glutamatergic postsynaptic density [GO:0099573]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic density, intracellular component [GO:0099092]; Schaffer collateral - CA1 synapse [GO:0098685]; T-tubule [GO:0030315] | calcium channel inhibitor activity [GO:0019855]; metal ion binding [GO:0046872]; zinc ion transmembrane transporter activity [GO:0005385]; zinc:proton antiporter activity [GO:0140826] | 12960.41995471195 | 0.148084029462561 | 0.277290356274135 | 0.600354283014615 |
| Q08945 | Q08945 | SSRP1_HUMAN | FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) | SSRP1 | DNA repair [GO:0006281]; DNA replication [GO:0006260]; nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337]; regulation of chromatin organization [GO:1902275] | FACT complex [GO:0035101]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | DNA binding [GO:0003677]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723] | 19867.89862000135 | 0.087230709164777 | 0.277710376204793 | 0.600804502320107 |
| Q9Y315 | Q9Y315 | DEOC_HUMAN | Deoxyribose-phosphate aldolase (DERA) (EC 4.1.2.4) (2-deoxy-D-ribose 5-phosphate aldolase) (Phosphodeoxyriboaldolase) (Deoxyriboaldolase) | DERA | carbohydrate catabolic process [GO:0016052]; deoxyribonucleoside catabolic process [GO:0046121]; deoxyribonucleotide catabolic process [GO:0009264]; deoxyribose phosphate catabolic process [GO:0046386]; pentose-phosphate shunt [GO:0006098] | cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; secretory granule lumen [GO:0034774] | deoxyribose-phosphate aldolase activity [GO:0004139] | 18171.58708618205 | -0.137509455641343 | 0.279294298164874 | 0.603773882544891 |
| Q03111 | Q03111 | ENL_HUMAN | Protein ENL (YEATS domain-containing protein 1) | MLLT1 | positive regulation of DNA-templated transcription [GO:0045893] | cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023] | chromatin binding [GO:0003682]; lysine-acetylated histone binding [GO:0070577] | 4923.830490816716 | -0.342843266686224 | 0.279375342491177 | 0.603773882544891 |
| Q9H936 | Q9H936 | GHC1_HUMAN | Mitochondrial glutamate carrier 1 (GC-1) (Glutamate/H(+) symporter 1) (Solute carrier family 25 member 22) | SLC25A22 | aspartate transmembrane transport [GO:0015810]; L-glutamate transmembrane transport [GO:0015813]; malate-aspartate shuttle [GO:0043490]; monoatomic ion transport [GO:0006811]; regulation of insulin secretion [GO:0050796] | mitochondrial inner membrane [GO:0005743] | amino acid:proton symporter activity [GO:0005280]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamate transmembrane transporter activity [GO:0005313] | 4557.186708977795 | -0.57322251440022 | 0.280638803441973 | 0.60598302602981 |
| Q9Y2B0 | Q9Y2B0 | CNPY2_HUMAN | Protein canopy homolog 2 (MIR-interacting saposin-like protein) (Putative secreted protein Zsig9) (Transmembrane protein 4) | CNPY2 | negative regulation of gene expression [GO:0010629]; positive regulation of low-density lipoprotein receptor activity [GO:1905599]; regulation of low-density lipoprotein particle clearance [GO:0010988] | endoplasmic reticulum [GO:0005783] | 109880.683349275 | 0.242747574434355 | 0.280763275642497 | 0.606020845634434 | |
| Q969E4 | Q969E4 | TCAL3_HUMAN | Transcription elongation factor A protein-like 3 (TCEA-like protein 3) (Transcription elongation factor S-II protein-like 3) | TCEAL3 | nucleus [GO:0005634] | 24736.2040936571 | 0.346747078042161 | 0.281222118372583 | 0.606549114084148 | ||
| Q9NX76 | Q9NX76 | CKLF6_HUMAN | CKLF-like MARVEL transmembrane domain-containing protein 6 (Chemokine-like factor superfamily member 6) | CMTM6 | endocytic recycling [GO:0032456]; protein transport [GO:0015031]; regulation of protein stability [GO:0031647] | azurophil granule membrane [GO:0035577]; early endosome membrane [GO:0031901]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; specific granule membrane [GO:0035579] | 3999.3280032692246 | -0.651845394826337 | 0.281347762611602 | 0.60658920203856 | |
| P16298 | P16298 | PP2BB_HUMAN | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit beta isoform) (CNA beta) | PPP3CB | axon extension [GO:0048675]; calcineurin-mediated signaling [GO:0097720]; calcineurin-NFAT signaling cascade [GO:0033173]; calcium-ion regulated exocytosis [GO:0017156]; dephosphorylation [GO:0016311]; heart development [GO:0007507]; learning [GO:0007612]; locomotion involved in locomotory behavior [GO:0031987]; lymphangiogenesis [GO:0001946]; memory [GO:0007613]; negative regulation of calcium ion import across plasma membrane [GO:1905949]; negative regulation of signaling [GO:0023057]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of lysosome organization [GO:1905673]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein dephosphorylation [GO:0006470]; protein phosphorylation [GO:0006468]; regulation of insulin secretion [GO:0050796]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic vesicle endocytosis [GO:1900242]; response to cytokine [GO:0034097]; signal transduction [GO:0007165]; skeletal muscle fiber development [GO:0048741]; T cell activation [GO:0042110]; T cell differentiation [GO:0030217]; T cell homeostasis [GO:0043029]; T cell mediated cytotoxicity [GO:0001913]; T cell proliferation [GO:0042098] | calcineurin complex [GO:0005955]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein serine/threonine phosphatase complex [GO:0008287]; T-tubule [GO:0030315]; Z disc [GO:0030018] | calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; calmodulin-dependent protein phosphatase activity [GO:0033192]; enzyme binding [GO:0019899]; myosin phosphatase activity [GO:0017018]; protein dimerization activity [GO:0046983]; protein phosphatase 2B binding [GO:0030346]; protein serine/threonine phosphatase activity [GO:0004722] | 8402.18464627101 | -0.387264515382715 | 0.281457774053463 | 0.606595567815489 |
| Q9NVS2 | Q9NVS2 | RT18A_HUMAN | Large ribosomal subunit protein mL66 (39S ribosomal protein S18-3, mitochondrial) (MRP-S18-3) (39S ribosomal protein S18a, mitochondrial) (MRP-S18-a) (Mrps18a) (S18mt-a) (Large ribosomal subunit protein bS18a) | MRPS18A | mitochondrial translation [GO:0032543]; translation [GO:0006412] | mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] | small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735] | 6349.083540798475 | 2.37893907694246 | 0.28217411154469 | 0.607908180993237 |
| Q9NPJ6 | Q9NPJ6 | MED4_HUMAN | Mediator of RNA polymerase II transcription subunit 4 (Activator-recruited cofactor 36 kDa component) (ARC36) (Mediator complex subunit 4) (TRAP/SMCC/PC2 subunit p36 subunit) (Vitamin D3 receptor-interacting protein complex 36 kDa component) (DRIP36) | MED4 | positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366] | core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | nuclear receptor coactivator activity [GO:0030374]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712] | 2697.39298356557 | 1.93553508764261 | 0.282493836796611 | 0.608134528605471 |
| Q15269 | Q15269 | PWP2_HUMAN | Periodic tryptophan protein 2 homolog | PWP2 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274] | nucleoplasm [GO:0005654]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040] | RNA binding [GO:0003723] | 2510.66479338481 | -0.256678716611134 | 0.282942887505898 | 0.608869882494652 |
| Q5VWZ2 | Q5VWZ2 | LYPL1_HUMAN | Lysophospholipase-like protein 1 (EC 3.1.2.22) | LYPLAL1 | negative regulation of cGAS/STING signaling pathway [GO:0160049] | cytoplasm [GO:0005737]; cytosol [GO:0005829] | carboxylic ester hydrolase activity [GO:0052689]; hydrolase activity, acting on ester bonds [GO:0016788]; lysophospholipase activity [GO:0004622]; palmitoyl-(protein) hydrolase activity [GO:0008474] | 25961.4738888827 | -0.128413000535176 | 0.284318689637127 | 0.611366108343059 |
| Q96J01 | Q96J01 | THOC3_HUMAN | THO complex subunit 3 (Tho3) (TEX1 homolog) (hTREX45) | THOC3 | mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380] | nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; THO complex part of transcription export complex [GO:0000445]; transcription export complex [GO:0000346] | RNA binding [GO:0003723] | 7128.77691198242 | 0.272545624288323 | 0.285503104245785 | 0.613447322205771 |
| Q53GA4 | Q53GA4 | PHLA2_HUMAN | Pleckstrin homology-like domain family A member 2 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein) (Imprinted in placenta and liver protein) (Tumor-suppressing STF cDNA 3 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein) (p17-Beckwith-Wiedemann region 1 C) (p17-BWR1C) | PHLDA2 | animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; placenta development [GO:0001890]; positive regulation of apoptotic process [GO:0043065]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; regulation of gene expression [GO:0010468]; regulation of glycogen metabolic process [GO:0070873]; regulation of spongiotrophoblast cell proliferation [GO:0060721] | cytoplasm [GO:0005737]; membrane [GO:0016020] | phosphatidylinositol phosphate binding [GO:1901981] | 7733.12790537993 | 0.507029432792918 | 0.285824719384959 | 0.613587453463843 |
| Q9UJF2 | Q9UJF2 | NGAP_HUMAN | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | RASAL2 | adipose tissue development [GO:0060612]; gene expression [GO:0010467]; multicellular organism growth [GO:0035264]; regulation of protein activation cascade [GO:2000257]; response to dietary excess [GO:0002021]; response to glucose [GO:0009749]; signal transduction [GO:0007165] | cytosol [GO:0005829] | GTPase activator activity [GO:0005096] | 6409.890568779991 | -0.430079306181766 | 0.285836876050704 | 0.613587453463843 |
| Q16576 | Q16576 | RBBP7_HUMAN | Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) | RBBP7 | brain development [GO:0007420]; cellular heat acclimation [GO:0070370]; chromatin remodeling [GO:0006338]; DNA replication [GO:0006260]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of cell fate specification [GO:0042659]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell differentiation [GO:2000736]; response to steroid hormone [GO:0048545] | ATPase complex [GO:1904949]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; ESC/E(Z) complex [GO:0035098]; histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; NURF complex [GO:0016589] | histone binding [GO:0042393]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723] | 18132.0866990483 | 0.170589412372234 | 0.285893201049161 | 0.613587453463843 |
| O75150 | O75150 | BRE1B_HUMAN | E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) | RNF40 | chromatin organization [GO:0006325]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] | HULC complex [GO:0033503]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] | metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; protein homodimerization activity [GO:0042803]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625] | 5158.33906028192 | -0.171296100771052 | 0.286064551453662 | 0.613722737045228 |
| P21912 | P21912 | SDHB_HUMAN | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC 1.3.5.1) (Iron-sulfur subunit of complex II) (Ip) | SDHB | aerobic respiration [GO:0009060]; mitochondrial electron transport, succinate to ubiquinone [GO:0006121]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; respiratory electron transport chain [GO:0022904]; tricarboxylic acid cycle [GO:0006099] | mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) [GO:0005749]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] | 2 iron, 2 sulfur cluster binding [GO:0051537]; 3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; succinate dehydrogenase (quinone) activity [GO:0008177]; ubiquinone binding [GO:0048039] | 41933.0000145121 | 0.178610386076482 | 0.286275075867289 | 0.613941930304337 |
| O75506 | O75506 | HSBP1_HUMAN | Heat shock factor-binding protein 1 (Nasopharyngeal carcinoma-associated antigen 13) (NPC-A-13) | HSBP1 | axonal transport of mitochondrion [GO:0019896]; cellular heat acclimation [GO:0070370]; endodermal cell differentiation [GO:0035987]; negative regulation of transcription by RNA polymerase II [GO:0000122] | axon cytoplasm [GO:1904115]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | identical protein binding [GO:0042802]; transcription corepressor activity [GO:0003714] | 5044.55329016117 | -1.38055811184713 | 0.286790385574902 | 0.614520299558085 |
| Q9C0E8 | Q9C0E8 | LNP_HUMAN | Endoplasmic reticulum junction formation protein lunapark (ER junction formation factor lunapark) | LNPK | blood coagulation [GO:0007596]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum tubular network maintenance [GO:0071788]; endoplasmic reticulum tubular network organization [GO:0071786]; limb development [GO:0060173]; positive regulation of endoplasmic reticulum tubular network organization [GO:1903373]; regulation of chondrocyte differentiation [GO:0032330] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; endoplasmic reticulum tubular network membrane [GO:0098826]; membrane [GO:0016020]; nucleoplasm [GO:0005654] | identical protein binding [GO:0042802]; metal ion binding [GO:0046872] | 76800.10988295244 | 0.138481594070267 | 0.286870136309766 | 0.614520299558085 |
| P40429 | P40429 | RL13A_HUMAN | Large ribosomal subunit protein uL13 (23 kDa highly basic protein) (60S ribosomal protein L13a) | RPL13A | cellular response to type II interferon [GO:0071346]; cytoplasmic translation [GO:0002181]; homeostatic process [GO:0042592]; lung morphogenesis [GO:0060425]; macrophage chemotaxis [GO:0048246]; negative regulation of formation of translation preinitiation complex [GO:1901194]; negative regulation of translation [GO:0017148]; response to lipopolysaccharide [GO:0032496]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; GAIT complex [GO:0097452]; large ribosomal subunit [GO:0015934]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; synapse [GO:0045202] | mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 204058.494814653 | 0.156009550809189 | 0.287119480127729 | 0.614821985791275 |
| P61978 | P61978 | HNRPK_HUMAN | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | HNRNPK | mRNA splicing, via spliceosome [GO:0000398]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of low-density lipoprotein receptor activity [GO:1905599]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902165]; regulation of low-density lipoprotein particle clearance [GO:0010988]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA processing [GO:0006396]; signal transduction [GO:0007165] | catalytic step 2 spliceosome [GO:0071013]; cell projection [GO:0042995]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; podosome [GO:0002102]; ribonucleoprotein complex [GO:1990904] | cadherin binding [GO:0045296]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723] | 214555.253121368 | 0.137828591360165 | 0.287508362637238 | 0.615422131735016 |
| P07108 | P07108 | ACBP_HUMAN | Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP) | DBI | fatty acid metabolic process [GO:0006631]; negative regulation of protein lipidation [GO:1903060]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of phospholipid transport [GO:2001140] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; perinuclear endoplasmic reticulum [GO:0097038]; protein-lipid complex [GO:0032994] | benzodiazepine receptor binding [GO:0030156]; fatty-acyl-CoA binding [GO:0000062]; identical protein binding [GO:0042802]; long-chain fatty acyl-CoA binding [GO:0036042] | 439364.0060912795 | 0.199632261508887 | 0.2884499662005 | 0.615673405958037 |
| Q14185 | Q14185 | DOCK1_HUMAN | Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180) | DOCK1 | apoptotic process [GO:0006915]; cell migration [GO:0016477]; integrin-mediated signaling pathway [GO:0007229]; myoblast fusion [GO:0007520]; phagocytosis, engulfment [GO:0006911]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; signal transduction [GO:0007165]; small GTPase-mediated signal transduction [GO:0007264] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; guanyl-nucleotide exchange factor complex [GO:0032045]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] | GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267] | 3276.8032044188503 | -0.406602339130481 | 0.287810471534991 | 0.615673405958037 |
| P00367 | P00367 | DHE3_HUMAN | Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3) | GLUD1 | glutamate biosynthetic process [GO:0006537]; glutamate catabolic process [GO:0006538]; glutamine metabolic process [GO:0006541]; positive regulation of insulin secretion [GO:0032024]; substantia nigra development [GO:0021762]; tricarboxylic acid metabolic process [GO:0072350] | cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] | ADP binding [GO:0043531]; ATP binding [GO:0005524]; glutamate dehydrogenase (NAD+) activity [GO:0004352]; glutamate dehydrogenase (NADP+) activity [GO:0004354]; glutamate dehydrogenase [NAD(P)+] activity [GO:0004353]; GTP binding [GO:0005525]; leucine binding [GO:0070728]; NAD+ binding [GO:0070403]; protein homodimerization activity [GO:0042803] | 45664.94391585355 | 0.128399741753847 | 0.288188817726743 | 0.615673405958037 |
| Q9Y2U5 | Q9Y2U5 | M3K2_HUMAN | Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) | MAP3K2 | cellular response to mechanical stimulus [GO:0071260]; intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] | ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | 4174.270393111315 | 0.148290933768982 | 0.288372606342761 | 0.615673405958037 |
| Q9NR46 | Q9NR46 | SHLB2_HUMAN | Endophilin-B2 (SH3 domain-containing GRB2-like protein B2) | SH3GLB2 | membrane organization [GO:0061024] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654] | cadherin binding [GO:0045296]; identical protein binding [GO:0042802] | 15949.9418304758 | 0.149652152337464 | 0.288284098573348 | 0.615673405958037 |
| Q04206 | Q04206 | TF65_HUMAN | Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) | RELA | acetaldehyde metabolic process [GO:0006117]; animal organ morphogenesis [GO:0009887]; canonical NF-kappaB signal transduction [GO:0007249]; cellular defense response [GO:0006968]; cellular response to angiotensin [GO:1904385]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-6 [GO:0071354]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to nicotine [GO:0071316]; cellular response to peptidoglycan [GO:0071224]; cellular response to tumor necrosis factor [GO:0071356]; chromatin organization [GO:0006325]; cytokine-mediated signaling pathway [GO:0019221]; defense response to tumor cell [GO:0002357]; defense response to virus [GO:0051607]; DNA-templated transcription [GO:0006351]; hair follicle development [GO:0001942]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; liver development [GO:0001889]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuropeptide signaling pathway [GO:0007218]; non-canonical NF-kappaB signal transduction [GO:0038061]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of miRNA metabolic process [GO:2000630]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of Schwann cell differentiation [GO:0014040]; positive regulation of T cell receptor signaling pathway [GO:0050862]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; postsynapse to nucleus signaling pathway [GO:0099527]; prolactin signaling pathway [GO:0038161]; protein catabolic process [GO:0030163]; regulation of DNA-templated transcription [GO:0006355]; regulation of inflammatory response [GO:0050727]; regulation of transcription by RNA polymerase II [GO:0006357]; response to amino acid [GO:0043200]; response to cAMP [GO:0051591]; response to cobalamin [GO:0033590]; response to cytokine [GO:0034097]; response to insulin [GO:0032868]; response to interleukin-1 [GO:0070555]; response to ischemia [GO:0002931]; response to muramyl dipeptide [GO:0032495]; response to muscle stretch [GO:0035994]; response to organic substance [GO:0010033]; response to progesterone [GO:0032570]; response to UV-B [GO:0010224]; response to xenobiotic stimulus [GO:0009410]; toll-like receptor 4 signaling pathway [GO:0034142]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; vascular endothelial growth factor signaling pathway [GO:0038084] | chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; NF-kappaB complex [GO:0071159]; NF-kappaB p50/p65 complex [GO:0035525]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] | actinin binding [GO:0042805]; ankyrin repeat binding [GO:0071532]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; general transcription initiation factor binding [GO:0140296]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; NF-kappaB binding [GO:0051059]; peptide binding [GO:0042277]; phosphate ion binding [GO:0042301]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; ubiquitin protein ligase binding [GO:0031625] | 36800.09574982965 | 0.0671873029434759 | 0.288849534857261 | 0.615965925668514 |
| Q9HA64 | Q9HA64 | KT3K_HUMAN | Ketosamine-3-kinase (EC 2.7.1.172) (Fructosamine-3-kinase-related protein) (FN3K-RP) (FN3K-related protein) (Protein-psicosamine 3-kinase FN3KRP) (EC 2.7.1.-) | FN3KRP | phosphorylation [GO:0016310]; post-translational protein modification [GO:0043687] | cytosol [GO:0005829] | ATP binding [GO:0005524]; kinase activity [GO:0016301]; protein-ribulosamine 3-kinase activity [GO:0102193] | 10336.683973051851 | 0.317814764118757 | 0.289008580831621 | 0.61607322008727 |
| Q9BSH4 | Q9BSH4 | TACO1_HUMAN | Translational activator of cytochrome c oxidase 1 (Coiled-coil domain-containing protein 44) (Translational activator of mitochondrially-encoded cytochrome c oxidase I) | TACO1 | mitochondrial cytochrome c oxidase assembly [GO:0033617]; motor learning [GO:0061743]; regulation of mitochondrial translation [GO:0070129] | cytosol [GO:0005829]; mitochondrion [GO:0005739] | mitochondrial ribosome binding [GO:0097177]; mRNA binding [GO:0003729]; rRNA binding [GO:0019843] | 23672.3793561034 | 0.613423117349641 | 0.289472139620423 | 0.616829312933177 |
| Q58FG1 | Q58FG1 | HS904_HUMAN | Putative heat shock protein HSP 90-alpha A4 (Heat shock 90 kDa protein 1 alpha-like 2) (Heat shock protein 90-alpha D) (Heat shock protein 90Ad) | HSP90AA4P | cellular response to heat [GO:0034605]; protein folding [GO:0006457]; protein stabilization [GO:0050821] | cytosol [GO:0005829]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; disordered domain specific binding [GO:0097718]; unfolded protein binding [GO:0051082] | 91203.44966908154 | 0.176766366780594 | 0.290553472185882 | 0.617739577262743 |
| Q9BYI3 | Q9BYI3 | HYCCI_HUMAN | Hyccin (Down-regulated by CTNNB1 protein A) | HYCC1 | myelination [GO:0042552]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659] | cytosol [GO:0005829]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] | 6928.46432877379 | 0.170953950141768 | 0.29029753557522 | 0.617739577262743 | |
| Q9NX24 | Q9NX24 | NHP2_HUMAN | H/ACA ribonucleoprotein complex subunit 2 (Nucleolar protein family A member 2) (snoRNP protein NHP2) | NHP2 | maturation of LSU-rRNA [GO:0000470]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; rRNA pseudouridine synthesis [GO:0031118]; snRNA pseudouridine synthesis [GO:0031120]; telomere maintenance via telomerase [GO:0007004] | box H/ACA scaRNP complex [GO:0072589]; box H/ACA snoRNP complex [GO:0031429]; box H/ACA telomerase RNP complex [GO:0090661]; chromosome, telomeric region [GO:0000781]; cytosolic large ribosomal subunit [GO:0022625]; nucleoplasm [GO:0005654]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]; telomerase holoenzyme complex [GO:0005697] | box H/ACA snoRNA binding [GO:0034513]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034] | 20528.89716643705 | -0.152820286717937 | 0.290299760944692 | 0.617739577262743 |
| P62269 | P62269 | RS18_HUMAN | Small ribosomal subunit protein uS13 (40S ribosomal protein S18) (Ke-3) (Ke3) | RPS18 | cytoplasmic translation [GO:0002181]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribosome [GO:0005840]; small ribosomal subunit [GO:0015935] | RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] | 268148.8948714025 | 0.1944082816374 | 0.290360054466356 | 0.617739577262743 |
| Q14694 | Q14694 | UBP10_HUMAN | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | USP10 | autophagy [GO:0006914]; cellular response to interleukin-1 [GO:0071347]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of stress granule assembly [GO:0062030]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of autophagy [GO:0010506]; rescue of stalled ribosome [GO:0072344]; translesion synthesis [GO:0019985] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; early endosome [GO:0005769]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] | cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; molecular function inhibitor activity [GO:0140678]; p53 binding [GO:0002039]; RNA binding [GO:0003723]; transmembrane transporter binding [GO:0044325] | 10561.57418877865 | 0.109451217657443 | 0.290539005880962 | 0.617739577262743 |
| Q96AT1 | Q96AT1 | K1143_HUMAN | Uncharacterized protein KIAA1143 | KIAA1143 | 5667.71581597116 | 0.368721614798761 | 0.290982093892557 | 0.617955226385018 | |||
| Q9H9C1 | Q9H9C1 | SPE39_HUMAN | Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction) | VIPAS39 | cell differentiation [GO:0030154]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; peptidyl-lysine hydroxylation [GO:0017185]; phagosome-lysosome fusion [GO:0090385]; post-translational protein modification [GO:0043687]; spermatogenesis [GO:0007283]; vacuolar transport [GO:0007034] | cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; recycling endosome [GO:0055037]; vesicle tethering complex [GO:0099023] | protein-containing complex binding [GO:0044877] | 13926.8788485604 | 0.132270186402852 | 0.290965749811484 | 0.617955226385018 |
| O60826 | O60826 | CCD22_HUMAN | Coiled-coil domain-containing protein 22 | CCDC22 | cytoplasmic sequestering of NF-kappaB [GO:0007253]; endocytic recycling [GO:0032456]; Golgi to plasma membrane transport [GO:0006893]; intracellular copper ion homeostasis [GO:0006878]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein transport [GO:0015031] | centrosome [GO:0005813]; cytosol [GO:0005829]; endosome [GO:0005768]; nucleoplasm [GO:0005654] | cullin family protein binding [GO:0097602] | 15207.0695926771 | -0.145159618129498 | 0.291135546063682 | 0.618049458222864 |
| Q9BZ23 | Q9BZ23 | PANK2_HUMAN | Pantothenate kinase 2, mitochondrial (hPanK2) (EC 2.7.1.33) (Pantothenic acid kinase 2) [Cleaved into: Pantothenate kinase 2, mitochondrial intermediate form (iPanK2); Pantothenate kinase 2, mitochondrial mature form (mPanK2)] | PANK2 | aerobic respiration [GO:0009060]; angiogenesis [GO:0001525]; coenzyme A biosynthetic process [GO:0015937]; mitochondrion organization [GO:0007005]; pantothenate metabolic process [GO:0015939]; phosphorylation [GO:0016310]; regulation of bile acid metabolic process [GO:1904251]; regulation of fatty acid metabolic process [GO:0019217]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of triglyceride metabolic process [GO:0090207]; spermatid development [GO:0007286] | cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleus [GO:0005634] | ATP binding [GO:0005524]; pantothenate kinase activity [GO:0004594] | 8552.572120604626 | 0.119432683894264 | 0.291257883201285 | 0.618076630083373 |
| O94923 | O94923 | GLCE_HUMAN | D-glucuronyl C5-epimerase (EC 5.1.3.17) (Heparan sulfate C5-epimerase) (Hsepi) (Heparin/heparan sulfate:glucuronic acid C5-epimerase) (Heparosan-N-sulfate-glucuronate 5-epimerase) | GLCE | heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparin biosynthetic process [GO:0030210]; negative regulation of cell projection organization [GO:0031345]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of SMAD protein signal transduction [GO:0060391] | Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] | calcium ion binding [GO:0005509]; heparosan-N-sulfate-glucuronate 5-epimerase activity [GO:0047464]; protein homodimerization activity [GO:0042803]; racemase and epimerase activity, acting on carbohydrates and derivatives [GO:0016857] | 3538.19654675775 | 2.87915637989969 | 0.29261668052014 | 0.620496299336494 |
| Q14999 | Q14999 | CUL7_HUMAN | Cullin-7 (CUL-7) | CUL7 | epithelial to mesenchymal transition [GO:0001837]; Golgi organization [GO:0007030]; microtubule cytoskeleton organization [GO:0000226]; mitotic cytokinesis [GO:0000281]; placenta development [GO:0001890]; positive regulation of dendrite morphogenesis [GO:0050775]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of mitotic nuclear division [GO:0007088]; ubiquitin-dependent protein catabolic process [GO:0006511]; vasculogenesis [GO:0001570] | 3M complex [GO:1990393]; anaphase-promoting complex [GO:0005680]; centrosome [GO:0005813]; Cul7-RING ubiquitin ligase complex [GO:0031467]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471] | ubiquitin protein ligase binding [GO:0031625] | 3253.88281804673 | -0.347993482675644 | 0.293209226536228 | 0.621520193622996 |
| P60866 | P60866 | RS20_HUMAN | Small ribosomal subunit protein uS10 (40S ribosomal protein S20) | RPS20 | cytoplasmic translation [GO:0002181]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; synapse [GO:0045202] | MDM2/MDM4 family protein binding [GO:0097371]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948] | 221241.073479814 | 0.174112653077283 | 0.293376007329831 | 0.621641158388491 |
| Q15643 | Q15643 | TRIPB_HUMAN | Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) | TRIP11 | cartilage development [GO:0051216]; chondrocyte differentiation involved in endochondral bone morphogenesis [GO:0003413]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; inner ear receptor cell stereocilium organization [GO:0060122]; protein glycosylation [GO:0006486]; protein transmembrane transport [GO:0071806]; transcription by RNA polymerase II [GO:0006366]; ventricular septum development [GO:0003281]; vesicle tethering to Golgi [GO:0099041] | cis-Golgi network [GO:0005801]; cytoskeleton [GO:0005856]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; inner acrosomal membrane [GO:0002079]; outer acrosomal membrane [GO:0002081]; transport vesicle [GO:0030133] | small GTPase binding [GO:0031267]; transcription coactivator activity [GO:0003713] | 9628.456055121409 | -0.156121906058083 | 0.293828021319456 | 0.622366193942444 |
| O15347 | O15347 | HMGB3_HUMAN | High mobility group protein B3 (High mobility group protein 2a) (HMG-2a) (High mobility group protein 4) (HMG-4) | HMGB3 | DNA geometric change [GO:0032392]; DNA recombination [GO:0006310]; innate immune response [GO:0045087]; regulation of transcription by RNA polymerase II [GO:0006357] | chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634] | DNA binding, bending [GO:0008301]; double-stranded DNA binding [GO:0003690]; four-way junction DNA binding [GO:0000400]; RNA binding [GO:0003723] | 18282.39585391485 | 0.395969029593799 | 0.294588446457564 | 0.623743698665381 |
| Q9BXW6 | Q9BXW6 | OSBL1_HUMAN | Oxysterol-binding protein-related protein 1 (ORP-1) (OSBP-related protein 1) | OSBPL1A | bile acid biosynthetic process [GO:0006699]; cholesterol metabolic process [GO:0008203]; vesicle-mediated transport [GO:0016192] | cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; organelle membrane contact site [GO:0044232]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886] | cholesterol binding [GO:0015485]; phospholipid binding [GO:0005543]; sterol transporter activity [GO:0015248] | 10592.71112402 | 0.174181605056143 | 0.295139131323574 | 0.624209898499204 |
| Q99470 | Q99470 | SDF2_HUMAN | Stromal cell-derived factor 2 (SDF-2) | SDF2 | chaperone cofactor-dependent protein refolding [GO:0051085] | endoplasmic reticulum [GO:0005783]; protein folding chaperone complex [GO:0101031] | misfolded protein binding [GO:0051787] | 38728.429806020504 | 0.289130021648041 | 0.294973066708237 | 0.624209898499204 |
| Q7Z7N9 | Q7Z7N9 | T179B_HUMAN | Transmembrane protein 179B | TMEM179B | azurophil granule membrane [GO:0035577]; ficolin-1-rich granule membrane [GO:0101003]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] | 79489.2015712868 | 0.21511583202454 | 0.29503506840671 | 0.624209898499204 | ||
| P08603 | P08603 | CFAH_HUMAN | Complement factor H (H factor 1) | CFH | complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; proteolysis [GO:0006508]; regulation of complement activation [GO:0030449]; regulation of complement activation, alternative pathway [GO:0030451]; regulation of complement-dependent cytotoxicity [GO:1903659] | blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; serine-type endopeptidase complex [GO:1905370]; symbiont cell surface [GO:0106139] | complement component C3b binding [GO:0001851]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; identical protein binding [GO:0042802] | 3967.97721266376 | 0.178922504130382 | 0.295502114269442 | 0.624403573229952 |
| O14656 | O14656 | TOR1A_HUMAN | Torsin-1A (Dystonia 1 protein) (Torsin ATPase-1A) (EC 3.6.4.-) (Torsin family 1 member A) | TOR1A | cell adhesion [GO:0007155]; chaperone cofactor-dependent protein refolding [GO:0051085]; chaperone-mediated protein folding [GO:0061077]; ERAD pathway [GO:0036503]; intermediate filament cytoskeleton organization [GO:0045104]; neuron projection development [GO:0031175]; nuclear envelope organization [GO:0006998]; nuclear membrane organization [GO:0071763]; organelle organization [GO:0006996]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; protein deneddylation [GO:0000338]; protein localization to nucleus [GO:0034504]; regulation of dopamine uptake involved in synaptic transmission [GO:0051584]; regulation of protein localization to cell surface [GO:2000008]; response to oxidative stress [GO:0006979]; synaptic vesicle membrane organization [GO:0048499]; synaptic vesicle transport [GO:0048489]; wound healing, spreading of cells [GO:0044319] | cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; growth cone [GO:0030426]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; secretory granule [GO:0030141]; synaptic vesicle [GO:0008021] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; misfolded protein binding [GO:0051787]; unfolded protein binding [GO:0051082] | 23855.743457992197 | 0.157183045902386 | 0.295469286217262 | 0.624403573229952 |
| O43505 | O43505 | B4GA1_HUMAN | Beta-1,4-glucuronyltransferase 1 (EC 2.4.1.-) (I-beta-1,3-N-acetylglucosaminyltransferase) (iGnT) (N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase) (Poly-N-acetyllactosamine extension enzyme) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1) | B4GAT1 | axon guidance [GO:0007411]; keratan sulfate biosynthetic process [GO:0018146]; protein O-linked mannosylation [GO:0035269] | extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] | glucuronosyltransferase activity [GO:0015020]; metal ion binding [GO:0046872]; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity [GO:0008532] | 9098.55635544217 | 0.162739990189961 | 0.296190934260274 | 0.625017432368269 |
| A6NDG6 | A6NDG6 | PGP_HUMAN | Glycerol-3-phosphate phosphatase (G3PP) (EC 3.1.3.21) (Aspartate-based ubiquitous Mg(2+)-dependent phosphatase) (AUM) (EC 3.1.3.48) (Phosphoglycolate phosphatase) (PGP) | PGP | glycerol biosynthetic process [GO:0006114]; glycerophospholipid metabolic process [GO:0006650]; negative regulation of gluconeogenesis [GO:0045721] | cytoplasm [GO:0005737] | ADP phosphatase activity [GO:0043262]; glycerol-1-phosphatase activity [GO:0000121]; glycerol-3-phosphatase activity [GO:0043136]; magnesium ion binding [GO:0000287]; phosphoglycolate phosphatase activity [GO:0008967]; protein tyrosine phosphatase activity [GO:0004725] | 13665.5996875499 | -0.316392920479715 | 0.29629312095679 | 0.625017432368269 |
| P29218 | P29218 | IMPA1_HUMAN | Inositol monophosphatase 1 (IMP 1) (IMPase 1) (EC 3.1.3.25) (D-galactose 1-phosphate phosphatase) (EC 3.1.3.94) (Inositol-1(or 4)-monophosphatase 1) (Lithium-sensitive myo-inositol monophosphatase A1) | IMPA1 | inositol biosynthetic process [GO:0006021]; inositol metabolic process [GO:0006020]; phosphate-containing compound metabolic process [GO:0006796]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; signal transduction [GO:0007165] | cytoplasm [GO:0005737]; cytosol [GO:0005829] | identical protein binding [GO:0042802]; inositol monophosphate 1-phosphatase activity [GO:0008934]; inositol monophosphate 3-phosphatase activity [GO:0052832]; inositol monophosphate 4-phosphatase activity [GO:0052833]; inositol monophosphate phosphatase activity [GO:0052834]; lithium ion binding [GO:0031403]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein homodimerization activity [GO:0042803] | 57869.267749000006 | -0.0666838364952205 | 0.296972737879399 | 0.625318642535154 |
| Q96ST2 | Q96ST2 | IWS1_HUMAN | Protein IWS1 homolog (IWS1-like protein) | IWS1 | chromatin remodeling [GO:0006338]; mRNA processing [GO:0006397]; poly(A)+ mRNA export from nucleus [GO:0016973]; regulation of mRNA export from nucleus [GO:0010793]; regulation of mRNA processing [GO:0050684]; RNA splicing [GO:0008380]; transcription elongation-coupled chromatin remodeling [GO:0140673] | nucleoplasm [GO:0005654]; nucleus [GO:0005634] | 3735.7852143055297 | 0.317462827965415 | 0.296987728037787 | 0.625318642535154 | |
| Q6WKZ4 | Q6WKZ4 | RFIP1_HUMAN | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | RAB11FIP1 | negative regulation of adiponectin secretion [GO:0070164]; protein transport [GO:0015031]; regulated exocytosis [GO:0045055] | cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; phagocytic vesicle membrane [GO:0030670]; recycling endosome [GO:0055037] | small GTPase binding [GO:0031267] | 8568.55759857077 | -0.609123434230432 | 0.29679117372674 | 0.625318642535154 |
| P49662 | P49662 | CASP4_HUMAN | Caspase-4 (CASP-4) (EC 3.4.22.57) (ICE and Ced-3 homolog 2) (ICH-2) (ICE(rel)-II) (Mih1) (Protease TX) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20] | CASP4 | apoptotic process [GO:0006915]; cellular response to amyloid-beta [GO:1904646]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; non-canonical inflammasome complex assembly [GO:0160075]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-18-mediated signaling pathway [GO:2000494]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; protein autoprocessing [GO:0016540]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; pyroptosis [GO:0070269]; regulation of inflammatory response [GO:0050727] | AIM2 inflammasome complex [GO:0097169]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; IPAF inflammasome complex [GO:0072557]; mitochondrion [GO:0005739]; NLRP1 inflammasome complex [GO:0072558]; NLRP3 inflammasome complex [GO:0072559]; non-canonical inflammasome complex [GO:0160074]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] | CARD domain binding [GO:0050700]; caspase binding [GO:0089720]; cysteine-type endopeptidase activity [GO:0004197]; lipid binding [GO:0008289]; lipopolysaccharide binding [GO:0001530] | 8237.487219973831 | 0.271271637833089 | 0.298567634598923 | 0.627247007152185 |
| Q14197 | Q14197 | ICT1_HUMAN | Large ribosomal subunit protein mL62 (39S ribosomal protein L58, mitochondrial) (MRP-L58) (Digestion substraction 1) (DS-1) (Immature colon carcinoma transcript 1 protein) (Peptidyl-tRNA hydrolase ICT1, mitochondrial) (EC 3.1.1.29) | MRPL58 | mitochondrial translation [GO:0032543]; mitochondrial translational termination [GO:0070126]; rescue of stalled ribosome [GO:0072344] | mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] | aminoacyl-tRNA hydrolase activity [GO:0004045]; translation release factor activity, codon nonspecific [GO:0016150] | 19752.18249491245 | 0.193642144138248 | 0.298153994660122 | 0.627247007152185 |
| O43314 | O43314 | VIP2_HUMAN | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) | PPIP5K2 | inositol metabolic process [GO:0006020]; inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; phosphorylation [GO:0016310]; sensory perception of sound [GO:0007605] | cytosol [GO:0005829] | ATP binding [GO:0005524]; diphosphoinositol-pentakisphosphate kinase activity [GO:0033857]; inositol heptakisphosphate kinase activity [GO:0000829]; inositol hexakisphosphate 1-kinase activity [GO:0052723]; inositol hexakisphosphate 3-kinase activity [GO:0052724]; inositol hexakisphosphate 5-kinase activity [GO:0000832]; inositol hexakisphosphate kinase activity [GO:0000828]; inositol-1,3,4,5,6-pentakisphosphate kinase activity [GO:0000827] | 8907.36630095299 | -0.186029130434579 | 0.298567804145684 | 0.627247007152185 |
| Q13769 | Q13769 | THOC5_HUMAN | THO complex subunit 5 homolog (Functional spliceosome-associated protein 79) (fSAP79) (NF2/meningioma region protein pK1.3) (Placental protein 39.2) (PP39.2) (hTREX90) | THOC5 | monocyte differentiation [GO:0030224]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; primitive hemopoiesis [GO:0060215]; RNA splicing [GO:0008380] | cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; THO complex [GO:0000347]; THO complex part of transcription export complex [GO:0000445]; transcription export complex [GO:0000346] | mRNA binding [GO:0003729] | 12950.1302456985 | -0.40751846832332 | 0.298560022729859 | 0.627247007152185 |
| Q9C0B5 | Q9C0B5 | ZDHC5_HUMAN | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | ZDHHC5 | innate immune response [GO:0045087]; lipid transport [GO:0006869]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of pattern recognition receptor signaling pathway [GO:0062208]; positive regulation of protein localization to phagocytic vesicle [GO:1905171]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein localization to plasma membrane [GO:0072659]; protein palmitoylation [GO:0018345]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072] | cell surface [GO:0009986]; dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; postsynaptic specialization, intracellular component [GO:0099091] | palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706] | 13702.623255070699 | 0.0923789263524308 | 0.29846073107223 | 0.627247007152185 |
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| Q15149 | |||||||||
| Q99715 | |||||||||
| P02452 | |||||||||
| P02751 | |||||||||
| P98160 | |||||||||
| P08123 | |||||||||
| P02461 | |||||||||
| P07996 | |||||||||
| Q8WWI1 | |||||||||
| P05997 | |||||||||
| P20908 | |||||||||
| Q8WUJ3 | |||||||||
| P21333 | |||||||||
| O75369 | |||||||||
| Q15063 | |||||||||
| P02786 | |||||||||
| Q12884 | |||||||||
| P12814 | |||||||||
| Q9UDY2 | |||||||||
| Q14195 | |||||||||
| Q02952 | |||||||||
| Q9NZM1 | |||||||||
| P35579 | |||||||||
| P35354 | |||||||||
| P47895 | |||||||||
| Q09666 | |||||||||
| P11717 | |||||||||
| Q14112 | |||||||||
| Q13620 | |||||||||
| P43490 | |||||||||
| Q3SY69 | |||||||||
| P17812 | |||||||||
| P21980 | |||||||||
| Q16647 | |||||||||
| P01024 | |||||||||
| Q5SW79 | |||||||||
| P06396 | |||||||||
| P12111 | |||||||||
| P35221 | |||||||||
| P12429 | |||||||||
| P78559 | |||||||||
| Q76M96 | |||||||||
| Q16881 | |||||||||
| P07093 | |||||||||
| P27487 | |||||||||
| P15144 | |||||||||
| Q9H5V8 | |||||||||
| P08729 | |||||||||
| Q04828 | |||||||||
| O94925 | |||||||||
| P08473 | |||||||||
| Q8IVL5 | |||||||||
| P35442 | |||||||||
| O60716 | |||||||||
| P08253 | |||||||||
| Q16822 | |||||||||
| Q9UJ72 | |||||||||
| Q9Y617 | |||||||||
| Q8WX93 | |||||||||
| Q32MZ4 | |||||||||
| Q6P179 | |||||||||
| P48681 | |||||||||
| O95340 | |||||||||
| P21580 | |||||||||
| Q00341 | |||||||||
| P49748 | |||||||||
| O43854 | |||||||||
| P07942 | |||||||||
| Q96KC8 | |||||||||
| Q96PD2 | |||||||||
| Q13418 | |||||||||
| Q7Z7G0 | |||||||||
| Q04446 | |||||||||
| P19022 | |||||||||
| O00469 | |||||||||
| Q8WUF5 | |||||||||
| Q14767 | |||||||||
| Q13308 | |||||||||
| P46940 | |||||||||
| Q9NZ08 | |||||||||
| O60488 | |||||||||
| P35222 | |||||||||
| Q9H4M9 | |||||||||
| Q9NZU5 | |||||||||
| Q15113 | |||||||||
| O94808 | |||||||||
| Q9UI42 | |||||||||
| Q15417 | |||||||||
| Q15582 | |||||||||
| P35908 | |||||||||
| P00750 | |||||||||
| Q9UHD8 | |||||||||
| P11047 | |||||||||
| Q8N6G6 | |||||||||
| Q05682 | |||||||||
| P17342 | |||||||||
| Q16363 | |||||||||
| Q9NR12 | |||||||||
| P05362 | |||||||||
| P00966 | |||||||||
| P05120 | |||||||||
| P15121 | |||||||||
| P04179 | |||||||||
| Q15785 | |||||||||
| O60271 | |||||||||
| Q9Y6N5 | |||||||||
| Q9P0V9 | |||||||||
| Q8IVF2 | |||||||||
| P01584 | |||||||||
| Q96AQ6 | |||||||||
| P54289 | |||||||||
| P13667 | |||||||||
| Q96HE7 | |||||||||
| P21810 | |||||||||
| Q16790 | |||||||||
| P23396 | |||||||||
| P01130 | |||||||||
| P51812 | |||||||||
| O95490 | |||||||||
| Q16222 | |||||||||
| Q7Z4N8 | |||||||||
| P08133 | |||||||||
| Q08431 | |||||||||
| P23142 | |||||||||
| Q01581 | |||||||||
| P10915 | |||||||||
| O75976 | |||||||||
| P23219 | |||||||||
| Q8IXK2 | |||||||||
| Q07954 | |||||||||
| P50225 | |||||||||
| P11413 | |||||||||
| Q5SSJ5 | |||||||||
| Q6PCE3 | |||||||||
| P05091 | |||||||||
| P49419 | |||||||||
| P41252 | |||||||||
| P50281 | |||||||||
| Q13618 | |||||||||
| Q00653 | |||||||||
| Q9BZG1 | |||||||||
| P11142 | |||||||||
| P63010 | |||||||||
| Q9UBG0 | |||||||||
| Q5GLZ8 | |||||||||
| P21266 | |||||||||
| Q9BS40 | |||||||||
| P35232 | |||||||||
| Q86VP6 | |||||||||
| P09601 | |||||||||
| Q8N8S7 | |||||||||
| Q16851 | |||||||||
| P28845 | |||||||||
| P26640 | |||||||||
| Q92626 | |||||||||
| P07686 | |||||||||
| P01583 | |||||||||
| Q96HH9 | |||||||||
| P48506 | |||||||||
| P47712 | |||||||||
| Q14314 | |||||||||
| Q53FA7 | |||||||||
| Q9H425 | |||||||||
| Q14204 | |||||||||
| P01033 | |||||||||
| Q92616 | |||||||||
| Q16666 | |||||||||
| Q99623 | |||||||||
| P23381 | |||||||||
| Q8N6Y2 | |||||||||
| P98155 | |||||||||
| P46977 | |||||||||
| Q86SQ0 | |||||||||
| Q70E73 | |||||||||
| Q6VY07 | |||||||||
| P41250 | |||||||||
| P56945 | |||||||||
| P29279 | |||||||||
| Q96C19 | |||||||||
| Q9UPN3 | |||||||||
| P26022 | |||||||||
| P00492 | |||||||||
| Q9BXS4 | |||||||||
| P50452 | |||||||||
| P05783 | |||||||||
| Q14980 | |||||||||
| Q9UBX5 | |||||||||
| O75094 | |||||||||
| Q06323 | |||||||||
| O14672 | |||||||||
| O00339 | |||||||||
| P52209 | |||||||||
| Q00325 | |||||||||
| P30044 | |||||||||
| P30740 | |||||||||
| P46734 | |||||||||
| P48307 | |||||||||
| P08648 | |||||||||
| O43175 | |||||||||
| O00116 |
