Selected Cell
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stat_data__min_2_Peptides
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| P29590 | P29590 | PML_HUMAN | Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19) | PML | apoptotic process [GO:0006915]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell fate commitment [GO:0045165]; cellular response to interleukin-4 [GO:0071353]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular senescence [GO:0090398]; chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; entrainment of circadian clock by photoperiod [GO:0043153]; extrinsic apoptotic signaling pathway [GO:0097191]; fibroblast migration [GO:0010761]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; maintenance of protein location in nucleus [GO:0051457]; myeloid cell differentiation [GO:0030099]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of translation in response to oxidative stress [GO:0032938]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; oncogene-induced cell senescence [GO:0090402]; PML body organization [GO:0030578]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of peptidyl-lysine acetylation [GO:2000758]; positive regulation of protein localization to chromosome, telomeric region [GO:1904816]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; positive regulation of telomere maintenance [GO:0032206]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein import into nucleus [GO:0006606]; protein monoubiquitination [GO:0006513]; protein stabilization [GO:0050821]; protein sumoylation [GO:0016925]; protein targeting [GO:0006605]; protein-containing complex assembly [GO:0065003]; protein-containing complex localization [GO:0031503]; regulation of calcium ion transport into cytosol [GO:0010522]; regulation of cell adhesion [GO:0030155]; regulation of cell cycle [GO:0051726]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; response to cytokine [GO:0034097]; response to gamma radiation [GO:0010332]; response to hypoxia [GO:0001666]; response to UV [GO:0009411]; retinoic acid receptor signaling pathway [GO:0048384]; SMAD protein signal transduction [GO:0060395]; suppression of viral release by host [GO:0044790]; transforming growth factor beta receptor signaling pathway [GO:0007179] | chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605] | cobalt ion binding [GO:0050897]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; SMAD binding [GO:0046332]; SUMO binding [GO:0032183]; SUMO transferase activity [GO:0019789]; sumo-dependent protein binding [GO:0140037]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein ligase activity [GO:0061659]; zinc ion binding [GO:0008270] | 28420.64858122075 | -0.18397769797986 | 0.150143204574388 | 0.386511311730341 |
| Q9Y678 | Q9Y678 | COPG1_HUMAN | Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP) | COPG1 | endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; establishment of Golgi localization [GO:0051683]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; organelle transport along microtubule [GO:0072384]; protein secretion [GO:0009306] | COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133] | structural molecule activity [GO:0005198] | 58250.47608817725 | -0.208886083021229 | 0.150266195842052 | 0.386652255059522 |
| A9UHW6 | A9UHW6 | MI4GD_HUMAN | MIF4G domain-containing protein (SLBP-interacting protein 1) (hSLIP1) | MIF4GD | cap-dependent translational initiation [GO:0002191]; regulation of translational initiation [GO:0006446] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; histone mRNA stem-loop binding complex [GO:0062073]; nucleolus [GO:0005730] | identical protein binding [GO:0042802]; RNA binding [GO:0003723]; translation activator activity [GO:0008494] | 5477.439463547606 | -0.250534773335668 | 0.15118622675161 | 0.388666588373241 |
| P62750 | P62750 | RL23A_HUMAN | Large ribosomal subunit protein uL23 (60S ribosomal protein L23a) | RPL23A | cytoplasmic translation [GO:0002181]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleus [GO:0005634] | cadherin binding [GO:0045296]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; TORC2 complex binding [GO:1904841] | 269571.34715662047 | 0.24607687571125 | 0.152265934249836 | 0.391264754403433 |
| P16949 | P16949 | STMN1_HUMAN | Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17) | STMN1 | axonogenesis [GO:0007409]; establishment of skin barrier [GO:0061436]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; intracellular signal transduction [GO:0035556]; microtubule depolymerization [GO:0007019]; mitotic cytokinesis [GO:0000281]; mitotic spindle organization [GO:0007052]; negative regulation of guanyl-nucleotide exchange factor activity [GO:1905098]; negative regulation of microtubule polymerization [GO:0031115]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of thrombin-activated receptor signaling pathway [GO:0070495]; neuron projection development [GO:0031175]; regulation of cell migration [GO:0030334]; regulation of microtubule polymerization or depolymerization [GO:0031110]; response to virus [GO:0009615]; signal transduction [GO:0007165] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; microtubule [GO:0005874]; neuron projection [GO:0043005] | tubulin binding [GO:0015631] | 74307.3049077323 | 0.291250545092748 | 0.152540139246793 | 0.391791672244936 |
| Q9UPU7 | Q9UPU7 | TBD2B_HUMAN | TBC1 domain family member 2B | TBC1D2B | endocytosis [GO:0006897] | cytosol [GO:0005829]; early endosome [GO:0005769] | GTPase activator activity [GO:0005096] | 3742.2598098108 | -0.537284290964178 | 0.154229730160714 | 0.395593323264194 |
| O75689 | O75689 | ADAP1_HUMAN | Arf-GAP with dual PH domain-containing protein 1 (Centaurin-alpha-1) (Cnt-a1) (Putative MAPK-activating protein PM25) | ADAP1 | cell surface receptor signaling pathway [GO:0007166]; regulation of GTPase activity [GO:0043087] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | GTPase activator activity [GO:0005096]; inositol 1,3,4,5 tetrakisphosphate binding [GO:0043533]; metal ion binding [GO:0046872]; phosphatidylinositol bisphosphate binding [GO:1902936]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547] | 2311.03610455345 | 3.00448920363243 | 0.154574809795604 | 0.396299037240676 |
| Q15018 | Q15018 | ABRX2_HUMAN | BRISC complex subunit Abraxas 2 (Abraxas brother protein 1) (Protein FAM175B) | ABRAXAS2 | attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic cell cycle [GO:0000278]; mitotic spindle assembly [GO:0090307]; protein K63-linked deubiquitination [GO:0070536]; response to ischemia [GO:0002931] | BRISC complex [GO:0070552]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleus [GO:0005634]; spindle pole [GO:0000922] | microtubule binding [GO:0008017]; polyubiquitin modification-dependent protein binding [GO:0031593] | 13725.6742799378 | 0.189895973244863 | 0.15531294956477 | 0.398011384999543 |
| Q14141 | Q14141 | SEPT6_HUMAN | Septin-6 | SEPTIN6 | cell differentiation [GO:0030154]; cilium assembly [GO:0060271]; cytoskeleton-dependent cytokinesis [GO:0061640]; mitotic cytokinesis [GO:0000281]; spermatogenesis [GO:0007283] | axon terminus [GO:0043679]; cell division site [GO:0032153]; cleavage furrow [GO:0032154]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; septin collar [GO:0032173]; septin complex [GO:0031105]; septin ring [GO:0005940]; sperm annulus [GO:0097227]; spindle [GO:0005819]; synaptic vesicle [GO:0008021] | GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090] | 26234.95991475285 | 0.0922138095847142 | 0.155596309962343 | 0.398557274975875 |
| P46976 | P46976 | GLYG_HUMAN | Glycogenin-1 (GN-1) (GN1) (EC 2.4.1.186) | GYG1 | glycogen biosynthetic process [GO:0005978] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; secretory granule lumen [GO:0034774] | glycogenin glucosyltransferase activity [GO:0008466]; glycosyltransferase activity [GO:0016757]; manganese ion binding [GO:0030145]; protein homodimerization activity [GO:0042803]; UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity [GO:0102751] | 37153.31534049195 | 0.126223524296629 | 0.155838779498276 | 0.398997977694184 |
| O60563 | O60563 | CCNT1_HUMAN | Cyclin-T1 (CycT1) (Cyclin-T) | CCNT1 | cell cycle [GO:0007049]; cell division [GO:0051301]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of transcription by RNA polymerase II [GO:0006357]; response to xenobiotic stimulus [GO:0009410]; transcription by RNA polymerase II [GO:0006366] | cyclin/CDK positive transcription elongation factor complex [GO:0008024]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-TEFb complex [GO:0070691] | 7SK snRNA binding [GO:0097322]; chromatin binding [GO:0003682]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; molecular condensate scaffold activity [GO:0140693]; protein kinase binding [GO:0019901]; RNA polymerase binding [GO:0070063]; transcription cis-regulatory region binding [GO:0000976] | 6075.200822865695 | 0.374363797258127 | 0.155954516362185 | 0.399113951991029 |
| Q9Y224 | Q9Y224 | RTRAF_HUMAN | RNA transcription, translation and transport factor protein (CLE7 homolog) (CLE) (hCLE) | RTRAF | negative regulation of protein kinase activity [GO:0006469]; positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA transport [GO:0050658]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388] | centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; tRNA-splicing ligase complex [GO:0072669] | identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA polymerase II complex binding [GO:0000993] | 100627.11956292095 | 0.190992675112577 | 0.156263091679257 | 0.399542724483154 |
| P40763 | P40763 | STAT3_HUMAN | Signal transducer and activator of transcription 3 (Acute-phase response factor) | STAT3 | astrocyte differentiation [GO:0048708]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; cellular response to hormone stimulus [GO:0032870]; cellular response to interleukin-17 [GO:0097398]; cellular response to leptin stimulus [GO:0044320]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; eating behavior [GO:0042755]; energy homeostasis [GO:0097009]; eye photoreceptor cell differentiation [GO:0001754]; glucose homeostasis [GO:0042593]; growth hormone receptor signaling pathway [GO:0060396]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; inflammatory response [GO:0006954]; interleukin-11-mediated signaling pathway [GO:0038154]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; interleukin-6-mediated signaling pathway [GO:0070102]; interleukin-9-mediated signaling pathway [GO:0038113]; intracellular receptor signaling pathway [GO:0030522]; leptin-mediated signaling pathway [GO:0033210]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of autophagy [GO:0010507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of glycolytic process [GO:0045820]; negative regulation of inflammatory response [GO:0050728]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of neuron migration [GO:2001223]; negative regulation of primary miRNA processing [GO:2000635]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphorylation [GO:0016310]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of metalloendopeptidase activity [GO:1904685]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; positive regulation of vascular endothelial growth factor production [GO:0010575]; protein import into nucleus [GO:0006606]; radial glial cell differentiation [GO:0060019]; receptor signaling pathway via JAK-STAT [GO:0007259]; receptor signaling pathway via STAT [GO:0097696]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of feeding behavior [GO:0060259]; regulation of multicellular organism growth [GO:0040014]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estradiol [GO:0032355]; response to leptin [GO:0044321]; response to peptide hormone [GO:0043434]; retinal rod cell differentiation [GO:0060221]; sexual reproduction [GO:0019953]; signal transduction [GO:0007165]; somatic stem cell population maintenance [GO:0035019]; T-helper 17 cell lineage commitment [GO:0072540]; T-helper 17 type immune response [GO:0072538]; temperature homeostasis [GO:0001659]; transforming growth factor beta receptor signaling pathway [GO:0007179] | chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667] | chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; nuclear receptor activity [GO:0004879]; primary miRNA binding [GO:0070878]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; RNA sequestering activity [GO:0140610]; signaling adaptor activity [GO:0035591]; signaling receptor binding [GO:0005102]; transcription cis-regulatory region binding [GO:0000976] | 28046.77065517265 | 0.173468582413523 | 0.15673216244063 | 0.400380717938959 |
| Q4VC31 | Q4VC31 | MIX23_HUMAN | Protein MIX23 (Coiled-coil domain-containing protein 58) | MIX23 | mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739] | 14567.3261431104 | 0.449262707608866 | 0.157094549445862 | 0.401125604849146 | ||
| Q8WWC4 | Q8WWC4 | MAIP1_HUMAN | m-AAA protease-interacting protein 1, mitochondrial (Matrix AAA peptidase-interacting protein 1) | MAIP1 | calcium import into the mitochondrion [GO:0036444]; mitochondrial calcium ion homeostasis [GO:0051560]; protein insertion into mitochondrial inner membrane from matrix [GO:0032979]; protein insertion into mitochondrial membrane [GO:0051204] | mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759] | ribosome binding [GO:0043022] | 8175.3266089421195 | 0.488953901791201 | 0.15779593792856 | 0.402553707475562 |
| Q13546 | Q13546 | RIPK1_HUMAN | Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) | RIPK1 | amyloid fibril formation [GO:1990000]; apoptotic process [GO:0006915]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to tumor necrosis factor [GO:0071356]; extrinsic apoptotic signaling pathway [GO:0097191]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; necroptotic process [GO:0070266]; necroptotic signaling pathway [GO:0097527]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of necroptotic process [GO:0060546]; peptidyl-serine autophosphorylation [GO:0036289]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-6-mediated signaling pathway [GO:0070105]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of miRNA processing [GO:1903800]; positive regulation of necroptotic process [GO:0060545]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of programmed cell death [GO:0043068]; positive regulation of programmed necrotic cell death [GO:0062100]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; programmed necrotic cell death [GO:0097300]; protein autophosphorylation [GO:0046777]; protein catabolic process [GO:0030163]; regulation of ATP:ADP antiporter activity [GO:0070926]; response to oxidative stress [GO:0006979]; response to tumor necrosis factor [GO:0034612]; ripoptosome assembly [GO:0097343]; ripoptosome assembly involved in necroptotic process [GO:1901026]; T cell apoptotic process [GO:0070231]; tumor necrosis factor-mediated signaling pathway [GO:0033209] | cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; endosome membrane [GO:0010008]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]; ripoptosome [GO:0097342] | ATP binding [GO:0005524]; death domain binding [GO:0070513]; death receptor binding [GO:0005123]; identical protein binding [GO:0042802]; JUN kinase kinase kinase activity [GO:0004706]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; signaling adaptor activity [GO:0035591]; ubiquitin protein ligase binding [GO:0031625] | 10942.927398965148 | 0.175311503111173 | 0.158303718089733 | 0.403667356749067 |
| P15880 | P15880 | RS2_HUMAN | Small ribosomal subunit protein uS5 (40S ribosomal protein S2) (40S ribosomal protein S4) (Protein LLRep3) | RPS2 | cytoplasmic translation [GO:0002181]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | cadherin binding [GO:0045296]; enzyme binding [GO:0019899]; fibroblast growth factor binding [GO:0017134]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 193920.48261623498 | -0.193202945321445 | 0.159680583180598 | 0.406995134638448 |
| Q9H8H0 | Q9H8H0 | NOL11_HUMAN | Nucleolar protein 11 | NOL11 | maturation of SSU-rRNA [GO:0030490]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838] | nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; t-UTP complex [GO:0034455] | RNA binding [GO:0003723] | 4628.398322276875 | -0.208125101342258 | 0.160198446085803 | 0.408131472806725 |
| P62834 | P62834 | RAP1A_HUMAN | Ras-related protein Rap-1A (EC 3.6.5.2) (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1) | RAP1A | cellular response to cAMP [GO:0071320]; cellular response to nerve growth factor stimulus [GO:1990090]; establishment of endothelial barrier [GO:0061028]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of vasculogenesis [GO:2001214]; protein localization to plasma membrane [GO:0072659]; Rap protein signal transduction [GO:0032486]; regulation of cell junction assembly [GO:1901888]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; synaptic vesicle exocytosis [GO:0016079] | anchoring junction [GO:0070161]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; guanyl-nucleotide exchange factor complex [GO:0032045]; late endosome [GO:0005770]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; specific granule membrane [GO:0035579]; sperm midpiece [GO:0097225] | G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein-containing complex binding [GO:0044877]; small GTPase binding [GO:0031267] | 16810.278987934253 | 0.528373451569363 | 0.160556599815058 | 0.408860087439155 |
| P39019 | P39019 | RS19_HUMAN | Small ribosomal subunit protein eS19 (40S ribosomal protein S19) | RPS19 | antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cytoplasmic translation [GO:0002181]; defense response to Gram-negative bacterium [GO:0050829]; erythrocyte differentiation [GO:0030218]; killing of cells of another organism [GO:0031640]; maturation of SSU-rRNA [GO:0030490]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; monocyte chemotaxis [GO:0002548]; negative regulation of respiratory burst involved in inflammatory response [GO:0060266]; nucleolus organization [GO:0007000]; positive regulation of respiratory burst involved in inflammatory response [GO:0060265]; response to extracellular stimulus [GO:0009991]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]; ribosome [GO:0005840]; small-subunit processome [GO:0032040] | fibroblast growth factor binding [GO:0017134]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 189248.53442573 | 0.272083916898679 | 0.160695352034466 | 0.409029588781348 |
| Q96QG7 | Q96QG7 | MTMR9_HUMAN | Myotubularin-related protein 9 (Inactive phosphatidylinositol 3-phosphatase 9) | MTMR9 | endocytosis [GO:0006897]; negative regulation of autophagy [GO:0010507]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of phosphatase activity [GO:0010922]; protein stabilization [GO:0050821]; regulation of phosphatidylinositol dephosphorylation [GO:0060304] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587] | enzyme regulator activity [GO:0030234]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein phosphatase binding [GO:0019903] | 6545.11459096583 | -0.234451772030518 | 0.160953363448098 | 0.409502360708092 |
| P08174 | P08174 | DAF_HUMAN | Complement decay-accelerating factor (CD antigen CD55) | CD55 | complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; negative regulation of complement activation [GO:0045916]; negative regulation of complement activation, classical pathway [GO:0045959]; positive regulation of CD4-positive, alpha-beta T cell activation [GO:2000516]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of T cell cytokine production [GO:0002726]; regulation of complement activation [GO:0030449]; regulation of complement-dependent cytotoxicity [GO:1903659]; regulation of lipopolysaccharide-mediated signaling pathway [GO:0031664]; respiratory burst [GO:0045730]; T cell mediated immunity [GO:0002456] | cell surface [GO:0009986]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule membrane [GO:0101003]; Golgi membrane [GO:0000139]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; side of membrane [GO:0098552]; transport vesicle [GO:0030133] | lipid binding [GO:0008289]; virus receptor activity [GO:0001618] | 24654.065614979852 | 0.396679777176167 | 0.161238470910249 | 0.410043615878578 |
| Q6P4E1 | Q6P4E1 | GOLM2_HUMAN | Protein GOLM2 (Cancer susceptibility candidate gene 4 protein) (CASC4) (Golgi membrane protein 2) | GOLM2 | Golgi apparatus [GO:0005794]; membrane [GO:0016020] | 22238.027556011948 | 0.199139415974344 | 0.162243400403782 | 0.412385545311172 | ||
| P26440 | P26440 | IVD_HUMAN | Isovaleryl-CoA dehydrogenase, mitochondrial (IVD) (EC 1.3.8.4) (Butyryl-CoA dehydrogenase) (EC 1.3.8.1) | IVD | branched-chain amino acid catabolic process [GO:0009083]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; leucine catabolic process [GO:0006552] | mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] | butyryl-CoA dehydrogenase activity [GO:0004085]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; isovaleryl-CoA dehydrogenase activity [GO:0008470] | 14341.4771795704 | 0.16092697234914 | 0.162377718247304 | 0.412385545311172 |
| Q99611 | Q99611 | SPS2_HUMAN | Selenide, water dikinase 2 (EC 2.7.9.3) (Selenium donor protein 2) (Selenophosphate synthase 2) | SEPHS2 | phosphorylation [GO:0016310]; selenium compound metabolic process [GO:0001887]; selenocysteine biosynthetic process [GO:0016260]; selenocysteine metabolic process [GO:0016259] | cytoplasm [GO:0005737]; cytosol [GO:0005829] | ATP binding [GO:0005524]; metal ion binding [GO:0046872]; selenide, water dikinase activity [GO:0004756] | 5186.8531063745395 | -0.729649812589103 | 0.162332664267969 | 0.412385545311172 |
| O43447 | O43447 | PPIH_HUMAN | Peptidyl-prolyl cis-trans isomerase H (PPIase H) (EC 5.2.1.8) (Rotamase H) (Small nuclear ribonucleoprotein particle-specific cyclophilin H) (CypH) (U-snRNP-associated cyclophilin SnuCyp-20) (USA-CYP) | PPIH | mRNA splicing, via spliceosome [GO:0000398]; positive regulation of viral genome replication [GO:0045070]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; protein-containing complex assembly [GO:0065003] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; spliceosomal complex [GO:0005681]; U4/U6 snRNP [GO:0071001]; U4/U6 x U5 tri-snRNP complex [GO:0046540] | cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; ribonucleoprotein complex binding [GO:0043021] | 15519.90857604415 | -0.251508153146363 | 0.162465535029192 | 0.412423710338443 |
| P35573 | P35573 | GDE_HUMAN | Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)] | AGL | glycogen biosynthetic process [GO:0005978]; glycogen catabolic process [GO:0005980]; response to glucocorticoid [GO:0051384]; response to nutrient [GO:0007584] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; inclusion body [GO:0016234]; isoamylase complex [GO:0043033]; nucleus [GO:0005634]; sarcoplasmic reticulum [GO:0016529]; secretory granule lumen [GO:0034774] | 4-alpha-glucanotransferase activity [GO:0004134]; amylo-alpha-1,6-glucosidase activity [GO:0004135]; beta-maltose 4-alpha-glucanotransferase activity [GO:0102500]; glycogen debranching enzyme activity [GO:0004133]; polysaccharide binding [GO:0030247]; polyubiquitin modification-dependent protein binding [GO:0031593] | 8690.265172895175 | -0.293809354738047 | 0.163254617559961 | 0.414241228434724 |
| P17813 | P17813 | EGLN_HUMAN | Endoglin (CD antigen CD105) | ENG | artery morphogenesis [GO:0048844]; atrial cardiac muscle tissue morphogenesis [GO:0055009]; atrioventricular canal morphogenesis [GO:1905222]; BMP signaling pathway [GO:0030509]; bone development [GO:0060348]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac atrium morphogenesis [GO:0003209]; cardiac ventricle morphogenesis [GO:0003208]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; cell migration involved in endocardial cushion formation [GO:0003273]; cell motility [GO:0048870]; cellular response to mechanical stimulus [GO:0071260]; central nervous system vasculogenesis [GO:0022009]; detection of hypoxia [GO:0070483]; dorsal aorta morphogenesis [GO:0035912]; endocardial cushion morphogenesis [GO:0003203]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; extracellular matrix constituent secretion [GO:0070278]; extracellular matrix disassembly [GO:0022617]; heart looping [GO:0001947]; negative regulation of cell migration [GO:0030336]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of gene expression [GO:0010629]; negative regulation of nitric-oxide synthase activity [GO:0051001]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of angiogenesis [GO:0045766]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905007]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell differentiation [GO:1905065]; regulation of cell adhesion [GO:0030155]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of phosphorylation [GO:0042325]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to hypoxia [GO:0001666]; response to xenobiotic stimulus [GO:0009410]; smooth muscle tissue development [GO:0048745]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vascular associated smooth muscle cell development [GO:0097084]; vasculogenesis [GO:0001570]; venous blood vessel morphogenesis [GO:0048845]; ventricular trabecula myocardium morphogenesis [GO:0003222]; wound healing [GO:0042060] | cell surface [GO:0009986]; endothelial microparticle [GO:0072563]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] | activin binding [GO:0048185]; coreceptor activity [GO:0015026]; galactose binding [GO:0005534]; glycosaminoglycan binding [GO:0005539]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; signaling receptor activator activity [GO:0030546]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]; transmembrane signaling receptor activity [GO:0004888]; type I transforming growth factor beta receptor binding [GO:0034713]; type II transforming growth factor beta receptor binding [GO:0005114] | 35213.687289862646 | 0.0879839838294817 | 0.164155059713869 | 0.415781210701288 |
| Q9NWU2 | Q9NWU2 | GID8_HUMAN | Glucose-induced degradation protein 8 homolog (Two hybrid-associated protein 1 with RanBPM) (Twa1) | GID8 | positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; Wnt signaling pathway [GO:0016055] | cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] | protein homodimerization activity [GO:0042803] | 10467.83328640365 | 0.307171494822619 | 0.164100330366884 | 0.415781210701288 |
| Q3ZCQ8 | Q3ZCQ8 | TIM50_HUMAN | Mitochondrial import inner membrane translocase subunit TIM50 | TIMM50 | intracellular protein transport [GO:0006886]; mitochondrial membrane organization [GO:0007006]; protein dephosphorylation [GO:0006470]; protein import into mitochondrial matrix [GO:0030150]; release of cytochrome c from mitochondria [GO:0001836] | endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744] | cysteine-type endopeptidase activator activity [GO:0140608]; interleukin-2 receptor binding [GO:0005134]; phosphoprotein phosphatase activity [GO:0004721]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723] | 18624.998921869 | 0.186967386826607 | 0.165191457317753 | 0.41821930168114 |
| Q9H9E3 | Q9H9E3 | COG4_HUMAN | Conserved oligomeric Golgi complex subunit 4 (COG complex subunit 4) (Component of oligomeric Golgi complex 4) | COG4 | glycosylation [GO:0070085]; Golgi organization [GO:0007030]; Golgi vesicle prefusion complex stabilization [GO:0048213]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890] | cytosol [GO:0005829]; Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119]; trans-Golgi network membrane [GO:0032588] | identical protein binding [GO:0042802] | 7391.7240469789995 | -0.279840911130247 | 0.165481562728554 | 0.418766652264398 |
| P30048 | P30048 | PRDX3_HUMAN | Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.24) (Antioxidant protein 1) (AOP-1) (HBC189) (Peroxiredoxin III) (Prx-III) (Peroxiredoxin-3) (Protein MER5 homolog) (Thioredoxin-dependent peroxiredoxin 3) | PRDX3 | cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; hydrogen peroxide catabolic process [GO:0042744]; maternal placenta development [GO:0001893]; mitochondrion organization [GO:0007005]; myeloid cell differentiation [GO:0030099]; negative regulation of apoptotic process [GO:0043066]; negative regulation of kinase activity [GO:0033673]; peptidyl-cysteine oxidation [GO:0018171]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; regulation of mitochondrial membrane potential [GO:0051881]; response to hydrogen peroxide [GO:0042542]; response to lipopolysaccharide [GO:0032496]; response to oxidative stress [GO:0006979] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] | alkyl hydroperoxide reductase activity [GO:0008785]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; thioredoxin peroxidase activity [GO:0008379] | 60591.62094425275 | 0.128814850062889 | 0.165763075966076 | 0.419291780546332 |
| Q92575 | Q92575 | UBXN4_HUMAN | UBX domain-containing protein 4 (Erasin) (UBX domain-containing protein 2) | UBXN4 | ERAD pathway [GO:0036503]; response to unfolded protein [GO:0006986] | cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635] | 34932.883991215655 | 0.189295285018958 | 0.166253522809988 | 0.420344694440603 | |
| Q13438 | Q13438 | OS9_HUMAN | Protein OS-9 (Amplified in osteosarcoma 9) | OS9 | endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein retention in ER lumen [GO:0006621]; protein targeting [GO:0006605]; protein ubiquitination [GO:0016567]; response to endoplasmic reticulum stress [GO:0034976]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent protein catabolic process [GO:0006511] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; Hrd1p ubiquitin ligase complex [GO:0000836] | carbohydrate binding [GO:0030246]; protease binding [GO:0002020] | 16249.535403031648 | 0.261296430924536 | 0.166838930988083 | 0.421636656101016 |
| Q02818 | Q02818 | NUCB1_HUMAN | Nucleobindin-1 (CALNUC) | NUCB1 | small GTPase-mediated signal transduction [GO:0007264] | endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] | calcium ion binding [GO:0005509]; DNA binding [GO:0003677]; G-protein alpha-subunit binding [GO:0001965]; guanyl-nucleotide exchange factor activity [GO:0005085] | 124508.5722377545 | -0.171872324373175 | 0.167380051477017 | 0.422815591470698 |
| Q7KZ85 | Q7KZ85 | SPT6H_HUMAN | Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein) | SUPT6H | blastocyst formation [GO:0001825]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; nucleosome organization [GO:0034728]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of isotype switching [GO:0045191]; regulation of mRNA export from nucleus [GO:0010793]; regulation of mRNA processing [GO:0050684]; regulation of muscle cell differentiation [GO:0051147]; RNA splicing [GO:0008380]; transcription elongation by RNA polymerase II [GO:0006368]; transcription elongation-coupled chromatin remodeling [GO:0140673] | nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023] | DNA binding [GO:0003677]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723] | 3416.4152256682346 | 0.880087072628666 | 0.168118371907586 | 0.424491397160599 |
| Q6Y1H2 | Q6Y1H2 | HACD2_HUMAN | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 2) (HACD2) (Protein-tyrosine phosphatase-like member B) | HACD2 | fatty acid elongation [GO:0030497]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid biosynthetic process [GO:0030148]; very long-chain fatty acid biosynthetic process [GO:0042761] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] | 3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; enzyme binding [GO:0019899]; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity [GO:0102158] | 2161.08214372159 | -0.676225246945098 | 0.16821612423134 | 0.424549024452014 |
| P22033 | P22033 | MUTA_HUMAN | Methylmalonyl-CoA mutase, mitochondrial (MCM) (EC 5.4.99.2) (Methylmalonyl-CoA isomerase) | MMUT | homocysteine metabolic process [GO:0050667]; positive regulation of GTPase activity [GO:0043547]; post-embryonic development [GO:0009791]; propionate metabolic process, methylmalonyl pathway [GO:0019678]; succinyl-CoA biosynthetic process [GO:1901290] | cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] | cobalamin binding [GO:0031419]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; methylmalonyl-CoA mutase activity [GO:0004494]; modified amino acid binding [GO:0072341]; protein homodimerization activity [GO:0042803] | 9799.927115416409 | -0.20585079103786 | 0.168360299619901 | 0.424723712220106 |
| P14854 | P14854 | CX6B1_HUMAN | Cytochrome c oxidase subunit 6B1 (Cytochrome c oxidase subunit VIb isoform 1) (COX VIb-1) | COX6B1 | cellular respiration [GO:0045333]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; substantia nigra development [GO:0021762] | mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277] | cytochrome-c oxidase activity [GO:0004129] | 6264.46400985664 | 0.437258852712633 | 0.168474950628074 | 0.42482379628779 |
| Q9BUL8 | Q9BUL8 | PDC10_HUMAN | Programmed cell death protein 10 (Cerebral cavernous malformations 3 protein) (TF-1 cell apoptosis-related protein 15) | PDCD10 | angiogenesis [GO:0001525]; cellular response to leukemia inhibitory factor [GO:1990830]; endothelium development [GO:0003158]; establishment of Golgi localization [GO:0051683]; Golgi reassembly [GO:0090168]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:0036481]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of gene expression [GO:0010629]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein stabilization [GO:0050821]; regulation of angiogenesis [GO:0045765]; regulation of Golgi organization [GO:1903358]; wound healing, spreading of cells [GO:0044319] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; FAR/SIN/STRIPAK complex [GO:0090443]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] | protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901] | 48611.979927315944 | 0.258986339976145 | 0.168846686415268 | 0.425571763891863 |
| Q9UI12 | Q9UI12 | VATH_HUMAN | V-type proton ATPase subunit H (V-ATPase subunit H) (Nef-binding protein 1) (NBP1) (Protein VMA13 homolog) (V-ATPase 50/57 kDa subunits) (Vacuolar proton pump subunit H) (Vacuolar proton pump subunit SFD) | ATP6V1H | endocytosis [GO:0006897]; endosomal lumen acidification [GO:0048388]; Golgi lumen acidification [GO:0061795]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035] | clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extrinsic component of synaptic vesicle membrane [GO:0098850]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221] | enzyme regulator activity [GO:0030234]; proton-transporting ATPase activity, rotational mechanism [GO:0046961] | 18227.9890396997 | -0.170052638721951 | 0.169064850279008 | 0.425921748320355 |
| Q86X27 | Q86X27 | RGPS2_HUMAN | Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2) | RALGPS2 | Ras protein signal transduction [GO:0007265] | cytoplasm [GO:0005737]; plasma membrane [GO:0005886] | guanyl-nucleotide exchange factor activity [GO:0005085] | 3371.3476086207 | 0.244331759247068 | 0.169135886643276 | 0.425921748320355 |
| Q8IUR0 | Q8IUR0 | TPPC5_HUMAN | Trafficking protein particle complex subunit 5 | TRAPPC5 | COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; TRAPP complex [GO:0030008]; TRAPPI protein complex [GO:1990070]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072] | 9786.38717623409 | -0.94584755441169 | 0.169589040896274 | 0.426873170021451 | |
| Q9Y3B3 | Q9Y3B3 | TMED7_HUMAN | Transmembrane emp24 domain-containing protein 7 (p24 family protein gamma-3) (p24gamma3) (p27) | TMED7 | endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886] | COPI vesicle coat [GO:0030126]; COPII vesicle coat [GO:0030127]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; transport vesicle [GO:0030133] | cargo receptor activity [GO:0038024] | 286557.4999138225 | 0.175266177413195 | 0.170298853473119 | 0.428469495461232 |
| Q8IYD1 | Q8IYD1 | ERF3B_HUMAN | Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b) (eRF3b) (EC 3.6.5.-) (G1 to S phase transition protein 2 homolog) | GSPT2 | cell cycle [GO:0007049]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; translation [GO:0006412]; translational termination [GO:0006415] | cytosol [GO:0005829]; translation release factor complex [GO:0018444] | GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; translation release factor activity [GO:0003747] | 18393.24660574535 | 0.157478090758556 | 0.170660670475487 | 0.429189240530007 |
| Q9NYJ1 | Q9NYJ1 | COA4_HUMAN | Cytochrome c oxidase assembly factor 4 homolog, mitochondrial (Coiled-coil-helix-coiled-coil-helix domain-containing protein 8) (E2-induced gene 2 protein) | COA4 | mitochondrial cytochrome c oxidase assembly [GO:0033617] | mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739] | 13368.70411575815 | 1.89552786919383 | 0.172542341113307 | 0.433728884094053 | |
| Q5VTQ0 | Q5VTQ0 | TT39B_HUMAN | Tetratricopeptide repeat protein 39B (TPR repeat protein 39B) | TTC39B | cholesterol homeostasis [GO:0042632]; lipid metabolic process [GO:0006629]; negative regulation of cholesterol storage [GO:0010887]; regulation of cholesterol efflux [GO:0010874]; regulation of cholesterol metabolic process [GO:0090181] | 1881.658609594025 | -0.470610024820391 | 0.172933192662628 | 0.43451861180774 | ||
| Q13884 | Q13884 | SNTB1_HUMAN | Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (BSYN2) (Syntrophin-2) (Tax interaction protein 43) (TIP-43) | SNTB1 | muscle contraction [GO:0006936] | cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; focal adhesion [GO:0005925]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; synapse [GO:0045202] | actin binding [GO:0003779]; calmodulin binding [GO:0005516]; PDZ domain binding [GO:0030165]; structural molecule activity [GO:0005198] | 3587.662767845755 | 0.286458264286076 | 0.173440601973158 | 0.435600377118755 |
| P0DP23;P0DP24;P0DP25 | P0DP23 | CALM1_HUMAN | Calmodulin-1 | CALM1 | autophagosome membrane docking [GO:0016240]; cellular response to interferon-beta [GO:0035458]; cellular response to type II interferon [GO:0071346]; detection of calcium ion [GO:0005513]; G protein-coupled receptor signaling pathway [GO:0007186]; G2/M transition of mitotic cell cycle [GO:0000086]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; negative regulation of calcium ion export across plasma membrane [GO:1905913]; negative regulation of high voltage-gated calcium channel activity [GO:1901842]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; organelle localization by membrane tethering [GO:0140056]; positive regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051343]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; regulation of calcium-mediated signaling [GO:0050848]; regulation of cardiac muscle cell action potential [GO:0098901]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of cytokinesis [GO:0032465]; regulation of heart rate [GO:0002027]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; response to calcium ion [GO:0051592]; substantia nigra development [GO:0021762] | calcium channel complex [GO:0034704]; catalytic complex [GO:1902494]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; myelin sheath [GO:0043209]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; sarcomere [GO:0030017]; sperm midpiece [GO:0097225]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922]; vesicle [GO:0031982]; voltage-gated potassium channel complex [GO:0008076] | adenylate cyclase activator activity [GO:0010856]; calcium channel inhibitor activity [GO:0019855]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein kinase binding [GO:0019901]; protein phosphatase activator activity [GO:0072542]; protein serine/threonine kinase activator activity [GO:0043539]; titin binding [GO:0031432]; transmembrane transporter binding [GO:0044325] | 173670.3587406695 | 0.369805832247023 | 0.173750663095644 | 0.435799582602885 |
| Q06787 | Q06787 | FMR1_HUMAN | Fragile X messenger ribonucleoprotein 1 (Fragile X messenger ribonucleoprotein) (FMRP) (Protein FMR-1) | FMR1 | animal organ development [GO:0048513]; cellular response to virus [GO:0098586]; DNA repair [GO:0006281]; glutamate receptor signaling pathway [GO:0007215]; modulation by host of viral RNA genome replication [GO:0044830]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; negative regulation of cytoplasmic translation [GO:2000766]; negative regulation of long-term synaptic depression [GO:1900453]; negative regulation of miRNA-mediated gene silencing [GO:0060965]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; negative regulation of voltage-gated calcium channel activity [GO:1901386]; nervous system development [GO:0007399]; non-membrane-bounded organelle assembly [GO:0140694]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of intracellular transport of viral material [GO:1901254]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor internalization [GO:0002092]; positive regulation of translation [GO:0045727]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of dendritic spine development [GO:0060998]; regulation of filopodium assembly [GO:0051489]; regulation of mRNA stability [GO:0043488]; regulation of neuronal action potential [GO:0098908]; regulation of neurotransmitter secretion [GO:0046928]; regulation of translation at presynapse, modulating synaptic transmission [GO:0099577]; regulatory ncRNA-mediated gene silencing [GO:0031047]; RNA splicing [GO:0008380]; stress granule assembly [GO:0034063] | axon [GO:0030424]; axon terminus [GO:0043679]; Cajal body [GO:0015030]; cell projection [GO:0042995]; chromocenter [GO:0010369]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic filopodium [GO:1902737]; dendritic spine [GO:0043197]; dendritic spine neck [GO:0044326]; filopodium tip [GO:0032433]; glial cell projection [GO:0097386]; growth cone [GO:0030426]; growth cone filopodium [GO:1990812]; intracellular non-membrane-bounded organelle [GO:0043232]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal ribonucleoprotein granule [GO:0071598]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202] | chromatin binding [GO:0003682]; dynein complex binding [GO:0070840]; G-quadruplex RNA binding [GO:0002151]; identical protein binding [GO:0042802]; methylated histone binding [GO:0035064]; microtubule binding [GO:0008017]; miRNA binding [GO:0035198]; molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; poly(A) binding [GO:0008143]; poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; RNA strand annealing activity [GO:0033592]; sequence-specific mRNA binding [GO:1990825]; signaling adaptor activity [GO:0035591]; siRNA binding [GO:0035197]; translation initiation factor binding [GO:0031369]; translation regulator activity [GO:0045182]; translation repressor activity [GO:0030371]; transmembrane transporter binding [GO:0044325] | 11984.728557567501 | 0.307350753827807 | 0.173633539513262 | 0.435799582602885 |
| Q9H5K3 | Q9H5K3 | SG196_HUMAN | Protein O-mannose kinase (POMK) (EC 2.7.1.183) (Protein kinase-like protein SgK196) (Sugen kinase 196) | POMK | brain development [GO:0007420]; carbohydrate phosphorylation [GO:0046835]; learning or memory [GO:0007611]; neuromuscular process [GO:0050905]; protein O-linked glycosylation [GO:0006493]; sensory perception of pain [GO:0019233] | endoplasmic reticulum membrane [GO:0005789] | ATP binding [GO:0005524]; carbohydrate kinase activity [GO:0019200]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]; protein kinase activity [GO:0004672] | 1637.881848182155 | 0.824975374677091 | 0.173734170070083 | 0.435799582602885 |
| Q9BSU1 | Q9BSU1 | PHAF1_HUMAN | Phagosome assembly factor 1 | PHAF1 | Golgi to plasma membrane protein transport [GO:0043001] | dendrite [GO:0030425]; phagophore assembly site [GO:0000407]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802] | 7998.69129524983 | -0.361290247032844 | 0.174205015906183 | 0.436745849612582 | |
| Q13885 | Q13885 | TBB2A_HUMAN | Tubulin beta-2A chain (Tubulin beta class IIa) | TUBB2A | cerebral cortex development [GO:0021987]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278] | cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; intercellular bridge [GO:0045171]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleus [GO:0005634] | GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; structural constituent of cytoskeleton [GO:0005200] | 474341.7657753665 | 0.0842765956481939 | 0.17466933609885 | 0.437522749043362 |
| O00487 | O00487 | PSDE_HUMAN | 26S proteasome non-ATPase regulatory subunit 14 (EC 3.4.19.-) (26S proteasome regulatory subunit RPN11) (26S proteasome-associated PAD1 homolog 1) | PSMD14 | double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K63-linked deubiquitination [GO:0070536]; regulation of proteasomal protein catabolic process [GO:0061136]; response to ethanol [GO:0045471]; ubiquitin-dependent protein catabolic process [GO:0006511] | cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, lid subcomplex [GO:0008541]; secretory granule lumen [GO:0034774] | endopeptidase activator activity [GO:0061133]; K63-linked deubiquitinase activity [GO:0061578]; metal ion binding [GO:0046872]; metal-dependent deubiquitinase activity [GO:0140492]; metallopeptidase activity [GO:0008237]; proteasome binding [GO:0070628] | 57285.6597607984 | 0.166214812119431 | 0.1750794833908 | 0.438356320323586 |
| Q14938 | Q14938 | NFIX_HUMAN | Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) | NFIX | DNA replication [GO:0006260]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] | chromatin [GO:0000785]; nucleus [GO:0005634] | DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837] | 9563.584800005166 | -0.190156882589402 | 0.175194492907386 | 0.438429751190879 |
| O60828 | O60828 | PQBP1_HUMAN | Polyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1) | PQBP1 | activation of innate immune response [GO:0002218]; alternative mRNA splicing, via spliceosome [GO:0000380]; cellular response to exogenous dsRNA [GO:0071360]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; neuron projection development [GO:0031175]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of type I interferon production [GO:0032481]; regulation of dendrite morphogenesis [GO:0048814]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484] | cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; neuronal ribonucleoprotein granule [GO:0071598]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; lipid binding [GO:0008289]; ribonucleoprotein complex binding [GO:0043021]; transcription coactivator activity [GO:0003713] | 7890.973705572635 | 0.618775644447151 | 0.175263569793036 | 0.438429751190879 |
| Q9BYD2 | Q9BYD2 | RM09_HUMAN | Large ribosomal subunit protein bL9m (39S ribosomal protein L9, mitochondrial) (L9mt) (MRP-L9) | MRPL9 | mitochondrial translation [GO:0032543]; translation [GO:0006412] | cytosolic large ribosomal subunit [GO:0022625]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 12272.16995656225 | 0.253432146882003 | 0.175612606517479 | 0.439109015237438 |
| Q86WA6 | Q86WA6 | BPHL_HUMAN | Valacyclovir hydrolase (VACVase) (Valacyclovirase) (EC 3.1.-.-) (Biphenyl hydrolase-like protein) (Biphenyl hydrolase-related protein) (Bph-rp) (Breast epithelial mucin-associated antigen) (MCNAA) | BPHL | amino acid metabolic process [GO:0006520]; response to toxic substance [GO:0009636]; xenobiotic metabolic process [GO:0006805] | mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] | alpha-amino-acid esterase activity [GO:0047658]; serine hydrolase activity [GO:0017171] | 7688.743691716731 | 0.328579824645318 | 0.175713751633979 | 0.439168115023434 |
| Q96PY6 | Q96PY6 | NEK1_HUMAN | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | NEK1 | cell cycle [GO:0007049]; cell division [GO:0051301]; cilium assembly [GO:0060271]; protein phosphorylation [GO:0006468] | centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentriolar material [GO:0000242] | 14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713] | 7531.2037225044205 | 0.94248670352781 | 0.175897055072249 | 0.439317959796739 |
| Q12802 | Q12802 | AKP13_HUMAN | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | AKAP13 | adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process [GO:0086023]; adrenergic receptor signaling pathway [GO:0071875]; bone development [GO:0060348]; cardiac muscle cell differentiation [GO:0055007]; G protein-coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of Rho protein signal transduction [GO:0035023]; regulation of sarcomere organization [GO:0060297]; regulation of small GTPase mediated signal transduction [GO:0051056] | actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634] | guanyl-nucleotide exchange factor activity [GO:0005085]; MAP-kinase scaffold activity [GO:0005078]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; protein kinase A binding [GO:0051018]; small GTPase binding [GO:0031267] | 3115.4434098297597 | -0.205069225323376 | 0.177265806016975 | 0.442266867852127 |
| P57088 | P57088 | TMM33_HUMAN | Transmembrane protein 33 (Protein DB83) (SHINC-3) | TMEM33 | endoplasmic reticulum tubular network organization [GO:0071786]; innate immune response [GO:0045087]; membrane organization [GO:0061024]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of PERK-mediated unfolded protein response [GO:1903899]; regulation of endoplasmic reticulum tubular network organization [GO:1903371]; response to endoplasmic reticulum stress [GO:0034976] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; melanosome [GO:0042470]; nuclear envelope [GO:0005635] | 5971.42413355139 | -1.38118494196616 | 0.177578124480178 | 0.442656248704219 | |
| Q7Z2K6 | Q7Z2K6 | ERMP1_HUMAN | Endoplasmic reticulum metallopeptidase 1 (EC 3.4.-.-) (Felix-ina) | ERMP1 | cellular response to oxidative stress [GO:0034599]; endoplasmic reticulum unfolded protein response [GO:0030968]; proteolysis [GO:0006508] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] | metal ion binding [GO:0046872]; metalloexopeptidase activity [GO:0008235] | 9580.759587444194 | -0.213423943793688 | 0.178074744240485 | 0.443698988947488 |
| Q9H0N5 | Q9H0N5 | PHS2_HUMAN | Pterin-4-alpha-carbinolamine dehydratase 2 (PHS 2) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase 2) (DcoH-like protein DCoHm) (Dimerization cofactor of hepatocyte nuclear factor 1 from muscle) (HNF-1-alpha dimerization cofactor) | PCBD2 | positive regulation of DNA-templated transcription [GO:0045893]; tetrahydrobiopterin biosynthetic process [GO:0006729] | nucleus [GO:0005634] | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity [GO:0008124]; identical protein binding [GO:0042802]; phenylalanine 4-monooxygenase activity [GO:0004505] | 12634.60575563705 | -0.292162719436511 | 0.178276819279073 | 0.444007234301198 |
| Q9BY43 | Q9BY43 | CHM4A_HUMAN | Charged multivesicular body protein 4a (Chromatin-modifying protein 4a) (CHMP4a) (SNF7 homolog associated with Alix-2) (SNF7-1) (hSnf-1) (Vacuolar protein sorting-associated protein 32-1) (Vps32-1) (hVps32-1) | CHMP4A | autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; membrane invagination [GO:0010324]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nervous system process [GO:0050877]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; plasma membrane tubulation [GO:0097320]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; protein polymerization [GO:0051258]; protein transport [GO:0015031]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle budding from membrane [GO:0006900]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702] | amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; membrane coat [GO:0030117]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | ATPase binding [GO:0051117]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; protein homodimerization activity [GO:0042803] | 27150.2067242235 | 0.263226173139289 | 0.178476159762465 | 0.444308401236436 |
| Q9Y3E7 | Q9Y3E7 | CHMP3_HUMAN | Charged multivesicular body protein 3 (Chromatin-modifying protein 3) (Neuroendocrine differentiation factor) (Vacuolar protein sorting-associated protein 24) (hVps24) | CHMP3 | apoptotic process [GO:0006915]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; endosome transport via multivesicular body sorting pathway [GO:0032509]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; positive regulation of cytokinesis [GO:0032467]; protein polymerization [GO:0051258]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of endosome size [GO:0051036]; regulation of mitotic spindle assembly [GO:1901673]; suppression of viral release by host [GO:0044790]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076] | amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; midbody [GO:0030496]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886] | identical protein binding [GO:0042802]; molecular function inhibitor activity [GO:0140678]; phosphatidylcholine binding [GO:0031210]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; ubiquitin-specific protease binding [GO:1990381] | 40767.3100103582 | 0.24620262486452 | 0.178605466298117 | 0.444435033836246 |
| Q9NP77 | Q9NP77 | SSU72_HUMAN | RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (CTD phosphatase SSU72) (EC 3.1.3.16) | SSU72 | co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; mRNA polyadenylation [GO:0006378]; termination of RNA polymerase II transcription [GO:0006369] | cytosol [GO:0005829]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654] | myosin phosphatase activity [GO:0017018]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420] | 22060.91224912535 | 0.136053546253056 | 0.178685433803076 | 0.44443883578939 |
| Q86TU7 | Q86TU7 | SETD3_HUMAN | Actin-histidine N-methyltransferase (EC 2.1.1.85) (Protein-L-histidine N-tele-methyltransferase) (SET domain-containing protein 3) (hSETD3) | SETD3 | actin modification [GO:0030047]; peptidyl-histidine methylation [GO:0018021]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of uterine smooth muscle contraction [GO:0070472] | chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] | actin binding [GO:0003779]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 methyltransferase activity [GO:0042800]; protein-L-histidine N-tele-methyltransferase activity [GO:0018064]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713] | 19641.79277684325 | 0.238300984383317 | 0.178900909656713 | 0.444660583598855 |
| Q6GQQ9 | Q6GQQ9 | OTU7B_HUMAN | OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne) | OTUD7B | adaptive immune response [GO:0002250]; in utero embryonic development [GO:0001701]; mucosal immune response [GO:0002385]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; proteolysis [GO:0006508] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] | cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type peptidase activity [GO:0008234]; DNA binding [GO:0003677]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; zinc ion binding [GO:0008270] | 6965.70867299595 | 0.294159127270222 | 0.179138585681411 | 0.444784937103801 |
| Q96CW5 | Q96CW5 | GCP3_HUMAN | Gamma-tubulin complex component 3 (GCP-3) (hGCP3) (Gamma-ring complex protein 104 kDa) (h104p) (hGrip104) (Spindle pole body protein Spc98 homolog) (hSpc98) | TUBGCP3 | cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; single fertilization [GO:0007338]; spindle assembly [GO:0051225] | centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; equatorial microtubule organizing center [GO:0000923]; gamma-tubulin complex [GO:0000930]; membrane [GO:0016020]; polar microtubule [GO:0005827]; spindle [GO:0005819] | gamma-tubulin binding [GO:0043015]; microtubule minus-end binding [GO:0051011]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198] | 8222.707412424184 | -0.325511112016802 | 0.179069564728877 | 0.444784937103801 |
| Q7L273 | Q7L273 | KCTD9_HUMAN | BTB/POZ domain-containing protein KCTD9 | KCTD9 | intracellular signal transduction [GO:0035556]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567] | cullin family protein binding [GO:0097602]; identical protein binding [GO:0042802]; protein self-association [GO:0043621] | 4834.20455844936 | 1.45335573992542 | 0.179324352446048 | 0.444856296391992 | |
| Q12824 | Q12824 | SNF5_HUMAN | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (BRG1-associated factor 47) (BAF47) (Integrase interactor 1 protein) (SNF5 homolog) (hSNF5) | SMARCB1 | blastocyst hatching [GO:0001835]; cell cycle [GO:0007049]; chromatin remodeling [GO:0006338]; DNA integration [GO:0015074]; hepatocyte differentiation [GO:0070365]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; nucleosome disassembly [GO:0006337]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of glucose mediated signaling pathway [GO:1902661]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter [GO:1900461]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase I preinitiation complex assembly [GO:0001188]; single stranded viral RNA replication via double stranded DNA intermediate [GO:0039692]; transcription initiation-coupled chromatin remodeling [GO:0045815] | bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; fibrillar center [GO:0001650]; germ cell nucleus [GO:0043073]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nuclear chromosome [GO:0000228]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]; XY body [GO:0001741] | DNA binding [GO:0003677]; identical protein binding [GO:0042802]; p53 binding [GO:0002039]; Tat protein binding [GO:0030957]; transcription coactivator activity [GO:0003713] | 15994.49806892195 | 0.367808708293475 | 0.179258506601655 | 0.444856296391992 |
| P62888 | P62888 | RL30_HUMAN | Large ribosomal subunit protein eL30 (60S ribosomal protein L30) | RPL30 | antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cytoplasmic translation [GO:0002181]; defense response to Gram-negative bacterium [GO:0050829]; killing of cells of another organism [GO:0031640]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 140528.8812950325 | 0.186472331450225 | 0.179433840000756 | 0.444933101726163 |
| Q17RY0 | Q17RY0 | CPEB4_HUMAN | Cytoplasmic polyadenylation element-binding protein 4 (CPE-BP4) (CPE-binding protein 4) (hCPEB-4) | CPEB4 | cellular response to amino acid stimulus [GO:0071230]; cellular response to decreased oxygen levels [GO:0036294]; cellular response to glucose starvation [GO:0042149]; ionotropic glutamate receptor signaling pathway [GO:0035235]; negative regulation of cytoplasmic translation [GO:2000766]; negative regulation of neuron apoptotic process [GO:0043524]; response to ischemia [GO:0002931] | cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; growth cone [GO:0030426]; messenger ribonucleoprotein complex [GO:1990124]; neuron projection [GO:0043005]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; synapse [GO:0045202] | metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; mRNA regulatory element binding translation repressor activity [GO:0000900]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135] | 1742.8731203667248 | 0.51951306711956 | 0.179820169278314 | 0.445501127735429 |
| Q5VYK3 | Q5VYK3 | ECM29_HUMAN | Proteasome adapter and scaffold protein ECM29 (Ecm29 proteasome adapter and scaffold) (Proteasome-associated protein ECM29 homolog) | ECPAS | ERAD pathway [GO:0036503]; proteasome assembly [GO:0043248] | centrosome [GO:0005813]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; late endosome [GO:0005770]; membrane [GO:0016020]; multivesicular body [GO:0005771]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502] | molecular adaptor activity [GO:0060090]; proteasome binding [GO:0070628] | 9425.902190839075 | -0.244006362839197 | 0.179767523620699 | 0.445501127735429 |
| O95159 | O95159 | ZFPL1_HUMAN | Zinc finger protein-like 1 (Zinc finger protein MCG4) | ZFPL1 | regulation of DNA-templated transcription [GO:0006355]; vesicle-mediated transport [GO:0016192] | Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleus [GO:0005634] | DNA binding [GO:0003677]; zinc ion binding [GO:0008270] | 11732.162250334699 | 0.380972987798201 | 0.180308860041482 | 0.44632153822413 |
| Q9BZH6 | Q9BZH6 | WDR11_HUMAN | WD repeat-containing protein 11 (Bromodomain and WD repeat-containing protein 2) (WD repeat-containing protein 15) | WDR11 | cilium assembly [GO:0060271]; head development [GO:0060322]; heart development [GO:0007507]; intracellular protein transport [GO:0006886]; multicellular organism growth [GO:0035264]; regulation of smoothened signaling pathway [GO:0008589]; vesicle tethering to Golgi [GO:0099041] | axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802] | 7743.725099417165 | -0.241448724380221 | 0.180431658834308 | 0.446430471159472 | |
| P13747 | P13747 | HLAE_HUMAN | HLA class I histocompatibility antigen, alpha chain E (MHC class I antigen E) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain E (sHLA-E)] | HLA-E | adaptive immune response [GO:0002250]; antibacterial humoral response [GO:0019731]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; antigen processing and presentation of exogenous peptide antigen via MHC class Ib [GO:0002477]; CD8-positive, alpha-beta T cell activation [GO:0036037]; defense response to Gram-positive bacterium [GO:0050830]; immune response [GO:0006955]; innate immune response [GO:0045087]; natural killer cell tolerance induction [GO:0002519]; negative regulation of natural killer cell activation [GO:0032815]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of antibody-dependent cellular cytotoxicity [GO:0001815]; positive regulation of CD8-positive, alpha-beta T cell activation [GO:2001187]; positive regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000566]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of natural killer cell cytokine production [GO:0002729]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell mediated immunity [GO:0002717]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of TRAIL production [GO:0032759]; positive regulation of tumor necrosis factor production [GO:0032760]; protection from natural killer cell mediated cytotoxicity [GO:0042270]; regulation of natural killer cell mediated immunity [GO:0002715] | cell surface [GO:0009986]; early endosome membrane [GO:0031901]; ER to Golgi transport vesicle membrane [GO:0012507]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I protein complex [GO:0042612]; MHC class Ib protein complex [GO:0032398]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] | beta-2-microglobulin binding [GO:0030881]; MHC class I protein binding [GO:0042288]; natural killer cell lectin-like receptor binding [GO:0046703]; peptide antigen binding [GO:0042605]; signaling receptor binding [GO:0005102]; T cell receptor binding [GO:0042608] | 7577.78535449832 | 0.247467335532213 | 0.180579748359517 | 0.446522073444005 |
| O00499 | O00499 | BIN1_HUMAN | Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Box-dependent myc-interacting protein 1) (Bridging integrator 1) | BIN1 | cytoskeleton organization [GO:0007010]; endocytosis [GO:0006897]; endosome to lysosome transport [GO:0008333]; lipid tube assembly [GO:0060988]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902960]; negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904878]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ventricular cardiac muscle cell action potential [GO:1903946]; nucleus localization [GO:0051647]; nucleus organization [GO:0006997]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of apoptotic process [GO:0043065]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of endocytosis [GO:0045807]; regulation of cell cycle process [GO:0010564]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of neuron differentiation [GO:0045664]; synaptic vesicle endocytosis [GO:0048488]; T-tubule organization [GO:0033292] | actin cytoskeleton [GO:0015629]; axon [GO:0030424]; axon initial segment [GO:0043194]; axon terminus [GO:0043679]; cerebellar mossy fiber [GO:0044300]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endosome [GO:0005768]; extrinsic component of synaptic vesicle membrane [GO:0098850]; glutamatergic synapse [GO:0098978]; I band [GO:0031674]; lipid tube [GO:0060987]; membrane [GO:0016020]; node of Ranvier [GO:0033268]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription repressor complex [GO:0090571]; synaptic vesicle [GO:0008021]; T-tubule [GO:0030315]; varicosity [GO:0043196]; vesicle [GO:0031982]; Z disc [GO:0030018] | actin filament binding [GO:0051015]; aspartic-type endopeptidase inhibitor activity [GO:0019828]; clathrin binding [GO:0030276]; GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; phospholipid binding [GO:0005543]; protease binding [GO:0002020]; protein-folding chaperone binding [GO:0051087]; RNA polymerase binding [GO:0070063]; tau protein binding [GO:0048156] | 12797.105091108551 | 0.24915989622748 | 0.181370000828093 | 0.447766495644476 |
| Q96EY1 | Q96EY1 | DNJA3_HUMAN | DnaJ homolog subfamily A member 3, mitochondrial (DnaJ protein Tid-1) (hTid-1) (Hepatocellular carcinoma-associated antigen 57) (Tumorous imaginal discs protein Tid56 homolog) | DNAJA3 | activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation-induced cell death of T cells [GO:0006924]; cellular senescence [GO:0090398]; mitochondrial DNA replication [GO:0006264]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; neuromuscular junction development [GO:0007528]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell proliferation [GO:0042102]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; response to heat [GO:0009408]; response to type II interferon [GO:0034341]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; small GTPase-mediated signal transduction [GO:0007264]; T cell differentiation in thymus [GO:0033077] | cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; nucleus [GO:0005634]; postsynaptic membrane [GO:0045211] | ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; GTPase regulator activity [GO:0030695]; Hsp70 protein binding [GO:0030544]; IkappaB kinase complex binding [GO:0106137]; metal ion binding [GO:0046872]; NF-kappaB binding [GO:0051059]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; type II interferon receptor binding [GO:0005133]; unfolded protein binding [GO:0051082] | 9947.92402610916 | 0.214708753777489 | 0.181603848745324 | 0.447766495644476 |
| Q5SRI9 | Q5SRI9 | MANEA_HUMAN | Glycoprotein endo-alpha-1,2-mannosidase (Endo-alpha mannosidase) (Endomannosidase) (hEndo) (EC 3.2.1.130) (Mandaselin) | MANEA | Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] | alpha-mannosidase activity [GO:0004559]; glycoprotein endo-alpha-1,2-mannosidase activity [GO:0004569] | 5080.63107115603 | 0.525782039574784 | 0.181583168887701 | 0.447766495644476 | |
| P42345 | P42345 | MTOR_HUMAN | Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1) | MTOR | 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; anoikis [GO:0043276]; behavioral response to pain [GO:0048266]; calcineurin-NFAT signaling cascade [GO:0033173]; cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; cellular response to nutrient [GO:0031670]; cellular response to nutrient levels [GO:0031669]; cellular response to osmotic stress [GO:0071470]; cellular response to starvation [GO:0009267]; cytoskeleton organization [GO:0007010]; DNA damage response [GO:0006974]; energy reserve metabolic process [GO:0006112]; germ cell development [GO:0007281]; heart morphogenesis [GO:0003007]; heart valve morphogenesis [GO:0003179]; inflammatory response [GO:0006954]; lysosome organization [GO:0007040]; macroautophagy [GO:0016236]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of cell size [GO:0045792]; negative regulation of lysosome organization [GO:1905672]; negative regulation of macroautophagy [GO:0016242]; negative regulation of protein localization to nucleus [GO:1900181]; neuronal action potential [GO:0019228]; nucleus localization [GO:0051647]; oligodendrocyte differentiation [GO:0048709]; peptidyl-serine phosphorylation [GO:0018105]; phosphorylation [GO:0016310]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell growth [GO:0030307]; positive regulation of cytoplasmic translational initiation [GO:1904690]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of gene expression [GO:0010628]; positive regulation of glycolytic process [GO:0045821]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of pentose-phosphate shunt [GO:1905857]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription by RNA polymerase III [GO:0045945]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]; positive regulation of wound healing, spreading of epidermal cells [GO:1903691]; post-embryonic development [GO:0009791]; protein autophosphorylation [GO:0046777]; protein catabolic process [GO:0030163]; protein destabilization [GO:0031648]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of autophagosome assembly [GO:2000785]; regulation of cell growth [GO:0001558]; regulation of cell size [GO:0008361]; regulation of cellular response to heat [GO:1900034]; regulation of circadian rhythm [GO:0042752]; regulation of locomotor rhythm [GO:1904059]; regulation of macroautophagy [GO:0016241]; regulation of membrane permeability [GO:0090559]; regulation of myelination [GO:0031641]; regulation of osteoclast differentiation [GO:0045670]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to amino acid [GO:0043200]; response to heat [GO:0009408]; response to nutrient [GO:0007584]; response to nutrient levels [GO:0031667]; rhythmic process [GO:0048511]; ruffle organization [GO:0031529]; T cell costimulation [GO:0031295]; T-helper 1 cell lineage commitment [GO:0002296]; TOR signaling [GO:0031929]; TORC1 signaling [GO:0038202]; voluntary musculoskeletal movement [GO:0050882] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; PML body [GO:0016605]; TORC1 complex [GO:0031931]; TORC2 complex [GO:0031932] | ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; phosphoprotein binding [GO:0051219]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ribosome binding [GO:0043022]; RNA polymerase III type 1 promoter sequence-specific DNA binding [GO:0001002]; RNA polymerase III type 2 promoter sequence-specific DNA binding [GO:0001003]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]; TFIIIC-class transcription factor complex binding [GO:0001156] | 4341.126448462295 | -0.42695972762697 | 0.181424215217518 | 0.447766495644476 |
| Q9H2D1 | Q9H2D1 | S2532_HUMAN | Solute carrier family 25 member 32 (Mitochondrial FAD transporter) | SLC25A32 | folate import into mitochondrion [GO:1904947]; folic acid metabolic process [GO:0046655]; folic acid transport [GO:0015884]; mitochondrial FAD transmembrane transport [GO:1990548] | mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] | FAD transmembrane transporter activity [GO:0015230]; folic acid transmembrane transporter activity [GO:0008517] | 1050.9376700598914 | -1.95867391707972 | 0.181512193755771 | 0.447766495644476 |
| O96005 | O96005 | CLPT1_HUMAN | Putative lipid scramblase CLPTM1 (Cleft lip and palate transmembrane protein 1) | CLPTM1 | cell differentiation [GO:0030154]; regulation of T cell differentiation in thymus [GO:0033081] | endomembrane system [GO:0012505]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886] | GABA receptor binding [GO:0050811] | 20358.54535796475 | 0.195860273302229 | 0.18171030170679 | 0.44783408850399 |
| Q9H467 | Q9H467 | CUED2_HUMAN | CUE domain-containing protein 2 | CUEDC2 | negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of macrophage cytokine production [GO:0010936] | cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654] | ubiquitin binding [GO:0043130] | 2188.75682603662 | 0.466815981655896 | 0.181909812790805 | 0.448130869249 |
| Q6PK04 | Q6PK04 | CC137_HUMAN | Coiled-coil domain-containing protein 137 | CCDC137 | chromosome [GO:0005694]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleus [GO:0005634] | RNA binding [GO:0003723] | 1407.430161815455 | 1.6464224994074 | 0.18223579704704 | 0.448349121176086 | |
| Q96CX2 | Q96CX2 | KCD12_HUMAN | BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain) | KCTD12 | protein homooligomerization [GO:0051260]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] | cell projection [GO:0042995]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235] | identical protein binding [GO:0042802]; RNA binding [GO:0003723] | 108284.488621282 | -0.146430961050493 | 0.182092371415983 | 0.448349121176086 |
| Q9P0P8 | Q9P0P8 | MRES1_HUMAN | Mitochondrial transcription rescue factor 1 | MTRES1 | regulation of mitochondrial transcription [GO:1903108]; rescue of stalled ribosome [GO:0072344] | mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] | ribosomal large subunit binding [GO:0043023]; RNA binding [GO:0003723]; tRNA binding [GO:0000049] | 9072.84082372694 | 0.556016998561278 | 0.1821993371533 | 0.448349121176086 |
| Q9BRS8 | Q9BRS8 | LARP6_HUMAN | La-related protein 6 (Acheron) (Achn) (La ribonucleoprotein domain family member 6) | LARP6 | positive regulation of collagen biosynthetic process [GO:0032967]; regulation of translation [GO:0006417]; RNA processing [GO:0006396] | cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] | mRNA 5'-UTR binding [GO:0048027]; mRNA binding [GO:0003729]; myosin binding [GO:0017022]; RNA stem-loop binding [GO:0035613]; sequence-specific mRNA binding [GO:1990825] | 11661.4373528588 | 0.183914193656106 | 0.182583033427422 | 0.449008449392263 |
| Q86WB0 | Q86WB0 | ZC3C1_HUMAN | Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase) | ZC3HC1 | cell cycle [GO:0007049]; cell division [GO:0051301]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; protein ubiquitination [GO:0016567] | nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | protein kinase binding [GO:0019901]; zinc ion binding [GO:0008270] | 4909.40291910166 | -0.233467790392259 | 0.183059442382433 | 0.449984729084106 |
| Q9UNN8 | Q9UNN8 | EPCR_HUMAN | Endothelial protein C receptor (Activated protein C receptor) (APC receptor) (Endothelial cell protein C receptor) (CD antigen CD201) | PROCR | blood coagulation [GO:0007596]; negative regulation of coagulation [GO:0050819] | cell surface [GO:0009986]; centrosome [GO:0005813]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] | signaling receptor activity [GO:0038023] | 21040.550549175 | 0.310326646527946 | 0.183279537892288 | 0.450330382349393 |
| Q9UBB5 | Q9UBB5 | MBD2_HUMAN | Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2) | MBD2 | cellular response to organic cyclic compound [GO:0071407]; chromatin remodeling [GO:0006338]; DNA methylation-dependent heterochromatin formation [GO:0006346]; embryonic organ development [GO:0048568]; maternal behavior [GO:0042711]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of Wnt signaling pathway [GO:0030177]; protein-containing complex assembly [GO:0065003]; regulation of cell population proliferation [GO:0042127]; response to estradiol [GO:0032355]; response to mechanical stimulus [GO:0009612]; response to nutrient levels [GO:0031667]; ventricular cardiac muscle tissue development [GO:0003229]; Wnt signaling pathway [GO:0016055] | chromatin [GO:0000785]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991] | C2H2 zinc finger domain binding [GO:0070742]; chromatin binding [GO:0003682]; identical protein binding [GO:0042802]; methyl-CpG binding [GO:0008327]; molecular adaptor activity [GO:0060090]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; satellite DNA binding [GO:0003696]; siRNA binding [GO:0035197] | 13131.9870886687 | 0.193565236689902 | 0.183572724181763 | 0.450855247166826 |
| P62851 | P62851 | RS25_HUMAN | Small ribosomal subunit protein eS25 (40S ribosomal protein S25) | RPS25 | cytoplasmic translation [GO:0002181]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribosome [GO:0005840]; small ribosomal subunit [GO:0015935] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 554140.668947459 | 0.239689911378948 | 0.184595395598165 | 0.45297423623179 |
| P43487 | P43487 | RANG_HUMAN | Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1) | RANBP1 | NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of mitotic centrosome separation [GO:0046604]; signal transduction [GO:0007165] | centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleus [GO:0005634] | cadherin binding [GO:0045296]; GDP-dissociation inhibitor activity [GO:0005092]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] | 226384.7557779385 | 0.190593667789801 | 0.184744832656675 | 0.453144684776071 |
| Q13405 | Q13405 | RM49_HUMAN | Large ribosomal subunit protein mL49 (39S ribosomal protein L49, mitochondrial) (L49mt) (MRP-L49) (Neighbor of FAU) (NOF) (Protein NOF1) | MRPL49 | mitochondrial translation [GO:0032543] | mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739] | structural constituent of ribosome [GO:0003735] | 12413.2994201096 | 0.240699999099128 | 0.184849495120703 | 0.453193835220488 |
| P78539 | P78539 | SRPX_HUMAN | Sushi repeat-containing protein SRPX | SRPX | autophagy [GO:0006914]; cell adhesion [GO:0007155]; negative regulation of cell proliferation involved in contact inhibition [GO:0060244]; phagolysosome assembly [GO:0001845]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; response to endoplasmic reticulum stress [GO:0034976] | autophagosome [GO:0005776]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] | 6688.013185502656 | -0.178838357266567 | 0.184924840633563 | 0.453193835220488 | |
| Q13492 | Q13492 | PICAL_HUMAN | Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) | PICALM | amyloid-beta clearance by transcytosis [GO:0150093]; axonogenesis [GO:0007409]; clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; dendrite morphogenesis [GO:0048813]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; hemopoiesis [GO:0030097]; intracellular iron ion homeostasis [GO:0006879]; learning or memory [GO:0007611]; membrane bending [GO:0097753]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of gene expression [GO:0010629]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of receptor-mediated endocytosis [GO:0048261]; positive regulation of amyloid precursor protein catabolic process [GO:1902993]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of Ras protein signal transduction [GO:0046579]; protein-containing complex assembly [GO:0065003]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of amyloid precursor protein catabolic process [GO:1902991]; regulation of endocytosis [GO:0030100]; regulation of protein localization [GO:0032880]; regulation of vesicle size [GO:0097494]; synaptic vesicle budding from presynaptic endocytic zone membrane [GO:0016185]; synaptic vesicle maturation [GO:0016188]; vesicle budding from membrane [GO:0006900]; vesicle cargo loading [GO:0035459]; vesicle-mediated transport [GO:0016192] | cell surface [GO:0009986]; clathrin coat of coated pit [GO:0030132]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome to plasma membrane transport vesicle [GO:0070381]; extrinsic component of presynaptic endocytic zone membrane [GO:0098894]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; neurofibrillary tangle [GO:0097418]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021]; vesicle [GO:0031982] | 1-phosphatidylinositol binding [GO:0005545]; amyloid-beta binding [GO:0001540]; cadherin binding [GO:0045296]; clathrin binding [GO:0030276]; clathrin heavy chain binding [GO:0032050]; low-density lipoprotein particle receptor binding [GO:0050750]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; small GTPase binding [GO:0031267]; SNARE binding [GO:0000149]; tau protein binding [GO:0048156] | 76089.1048445559 | 0.138153804293289 | 0.185133407894341 | 0.453508815014844 |
| Q92979 | Q92979 | NEP1_HUMAN | Ribosomal RNA small subunit methyltransferase NEP1 (EC 2.1.1.-) (18S rRNA (pseudouridine(1248)-N1)-methyltransferase) (18S rRNA Psi1248 methyltransferase) (Nucleolar protein EMG1 homolog) (Protein C2f) (Ribosome biogenesis protein NEP1) | EMG1 | blastocyst development [GO:0001824]; nucleologenesis [GO:0017126]; ribosomal small subunit biogenesis [GO:0042274]; rRNA base methylation [GO:0070475]; rRNA processing [GO:0006364] | chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040] | identical protein binding [GO:0042802]; RNA binding [GO:0003723]; rRNA (pseudouridine) methyltransferase activity [GO:0070037]; rRNA binding [GO:0019843] | 5230.83452959731 | -0.26211266273933 | 0.185569949545601 | 0.454381734712781 |
| Q9UJ68 | Q9UJ68 | MSRA_HUMAN | Mitochondrial peptide methionine sulfoxide reductase (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase) (Protein-methionine-S-oxide reductase) (PMSR) | MSRA | cellular response to oxidative stress [GO:0034599]; methionine metabolic process [GO:0006555]; protein modification process [GO:0036211]; protein repair [GO:0030091]; response to oxidative stress [GO:0006979] | actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] | L-methionine-(S)-S-oxide reductase activity [GO:0036456]; peptide-methionine (S)-S-oxide reductase activity [GO:0008113] | 7475.65586895476 | 0.305714154136723 | 0.187469074453456 | 0.45843753813262 |
| Q8WXF1 | Q8WXF1 | PSPC1_HUMAN | Paraspeckle component 1 (Paraspeckle protein 1) | PSPC1 | activation of innate immune response [GO:0002218]; innate immune response [GO:0045087]; negative regulation of DNA-templated transcription [GO:0045892]; non-membrane-bounded organelle assembly [GO:0140694]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; rhythmic process [GO:0048511] | cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382] | RNA binding [GO:0003723] | 20209.6443654731 | 0.159579921194964 | 0.187428507921005 | 0.45843753813262 |
| P62917 | P62917 | RL8_HUMAN | Large ribosomal subunit protein uL2 (60S ribosomal protein L8) | RPL8 | cytoplasmic translation [GO:0002181]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069] | RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] | 115634.25446631349 | 0.155176452541273 | 0.188831412333773 | 0.460774669372591 |
| O76074 | O76074 | PDE5A_HUMAN | cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (cGMP-binding cGMP-specific phosphodiesterase) (CGB-PDE) | PDE5A | cAMP-mediated signaling [GO:0019933]; cGMP catabolic process [GO:0046069]; negative regulation of cardiac muscle contraction [GO:0055118]; negative regulation of T cell proliferation [GO:0042130]; oocyte development [GO:0048599]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of oocyte development [GO:0060282]; regulation of nitric oxide mediated signal transduction [GO:0010749]; relaxation of cardiac muscle [GO:0055119]; T cell proliferation [GO:0042098] | cytosol [GO:0005829] | 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; cGMP binding [GO:0030553]; metal ion binding [GO:0046872] | 6469.0486742321955 | 0.333816395055235 | 0.189090231216973 | 0.461207597966152 |
| Q8TBM8 | Q8TBM8 | DJB14_HUMAN | DnaJ homolog subfamily B member 14 | DNAJB14 | cellular response to misfolded protein [GO:0071218]; chaperone cofactor-dependent protein refolding [GO:0051085]; protein-containing complex assembly [GO:0065003] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965] | Hsp70 protein binding [GO:0030544] | 5691.322182094145 | 0.704421742493299 | 0.18930975920743 | 0.461343542424833 |
| Q9BPX6 | Q9BPX6 | MICU1_HUMAN | Calcium uptake protein 1, mitochondrial (Atopy-related autoantigen CALC) (ara CALC) (Calcium-binding atopy-related autoantigen 1) (allergen Hom s 4) | MICU1 | calcium import into the mitochondrion [GO:0036444]; calcium ion import [GO:0070509]; defense response [GO:0006952]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; protein homooligomerization [GO:0051260]; regulation of cellular hyperosmotic salinity response [GO:1900069] | calcium channel complex [GO:0034704]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; uniplex complex [GO:1990246] | calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982] | 4258.858395756555 | -0.679900579746069 | 0.189542963927135 | 0.461343542424833 |
| P46779 | P46779 | RL28_HUMAN | Large ribosomal subunit protein eL28 (60S ribosomal protein L28) | RPL28 | cytoplasmic translation [GO:0002181]; translation [GO:0006412] | cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; synapse [GO:0045202] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 182018.56634373352 | 0.198418723758839 | 0.189407898159796 | 0.461343542424833 |
| Q9UGQ3 | Q9UGQ3 | GTR6_HUMAN | Solute carrier family 2, facilitated glucose transporter member 6 (Glucose transporter type 6) (GLUT-6) | SLC2A6 | dehydroascorbic acid transport [GO:0070837]; fructose transmembrane transport [GO:0015755]; glucose transmembrane transport [GO:1904659]; hexose transmembrane transport [GO:0008645]; regulation of glycolytic process [GO:0006110]; transmembrane transport [GO:0055085] | lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] | D-glucose transmembrane transporter activity [GO:0055056]; dehydroascorbic acid transmembrane transporter activity [GO:0033300]; fructose transmembrane transporter activity [GO:0005353]; glucose transmembrane transporter activity [GO:0005355]; transmembrane transporter activity [GO:0022857] | 1742.72585721765 | 0.979410074397145 | 0.189553082732971 | 0.461343542424833 |
| Q9H1K0 | Q9H1K0 | RBNS5_HUMAN | Rabenosyn-5 (110 kDa protein) (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20) | RBSN | early endosome to Golgi transport [GO:0034498]; endosomal transport [GO:0016197]; Golgi to lysosome transport [GO:0090160]; protein transport [GO:0015031]; regulation of Golgi organization [GO:1903358] | cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] | small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270] | 12501.1426908225 | -0.544737619545527 | 0.189790551588867 | 0.461525006567606 |
| O75116 | O75116 | ROCK2_HUMAN | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) | ROCK2 | actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; aortic valve morphogenesis [GO:0003180]; blood vessel diameter maintenance [GO:0097746]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to acetylcholine [GO:1905145]; cellular response to testosterone stimulus [GO:0071394]; centrosome duplication [GO:0051298]; cortical actin cytoskeleton organization [GO:0030866]; embryonic morphogenesis [GO:0048598]; epithelial to mesenchymal transition [GO:0001837]; mitotic cytokinesis [GO:0000281]; modulation by host of viral process [GO:0044788]; mRNA destabilization [GO:0061157]; negative regulation of angiogenesis [GO:0016525]; negative regulation of bicellular tight junction assembly [GO:1903347]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of gene expression [GO:0010629]; negative regulation of myosin-light-chain-phosphatase activity [GO:0035509]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of protein localization to lysosome [GO:0150033]; positive regulation of amyloid precursor protein catabolic process [GO:1902993]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell migration [GO:0030335]; positive regulation of centrosome duplication [GO:0010825]; positive regulation of connective tissue growth factor production [GO:0032723]; positive regulation of connective tissue replacement [GO:1905205]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of fibroblast growth factor production [GO:0090271]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of angiotensin-activated signaling pathway [GO:0110061]; regulation of cell adhesion [GO:0030155]; regulation of cell junction assembly [GO:1901888]; regulation of cell motility [GO:2000145]; regulation of cellular response to hypoxia [GO:1900037]; regulation of circadian rhythm [GO:0042752]; regulation of establishment of cell polarity [GO:2000114]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of focal adhesion assembly [GO:0051893]; regulation of keratinocyte differentiation [GO:0045616]; regulation of nervous system process [GO:0031644]; regulation of stress fiber assembly [GO:0051492]; response to angiotensin [GO:1990776]; response to ischemia [GO:0002931]; response to transforming growth factor beta [GO:0071559]; Rho protein signal transduction [GO:0007266]; rhythmic process [GO:0048511]; smooth muscle contraction [GO:0006939] | centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | ATP binding [GO:0005524]; endopeptidase activator activity [GO:0061133]; metal ion binding [GO:0046872]; protease binding [GO:0002020]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; structural molecule activity [GO:0005198]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321] | 15132.8201691244 | -0.169029701125597 | 0.189721333766813 | 0.461525006567606 |
| P56545 | P56545 | CTBP2_HUMAN | C-terminal-binding protein 2 (CtBP2) | CTBP2 | negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of retinoic acid receptor signaling pathway [GO:0048386]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; viral genome replication [GO:0019079]; white fat cell differentiation [GO:0050872] | nucleus [GO:0005634]; synapse [GO:0045202]; transcription repressor complex [GO:0017053] | DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; transcription coactivator activity [GO:0003713]; transcription coregulator binding [GO:0001221]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222] | 10757.4889458545 | -0.21992957109065 | 0.190308746219404 | 0.462586596344548 |
| P53621 | P53621 | COPA_HUMAN | Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin] | COPA | endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; pancreatic juice secretion [GO:0030157]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890] | COPI vesicle coat [GO:0030126]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; growth cone [GO:0030426]; membrane [GO:0016020]; transport vesicle [GO:0030133] | hormone activity [GO:0005179]; structural molecule activity [GO:0005198] | 76552.83376704555 | -0.24899545842889 | 0.190983829986061 | 0.464028465137659 |
| P35268 | P35268 | RL22_HUMAN | Large ribosomal subunit protein eL22 (60S ribosomal protein L22) (EBER-associated protein) (EAP) (Epstein-Barr virus small RNA-associated protein) (Heparin-binding protein HBp15) | RPL22 | alpha-beta T cell differentiation [GO:0046632]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]; translation at presynapse [GO:0140236] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; presynapse [GO:0098793]; ribonucleoprotein complex [GO:1990904] | heparin binding [GO:0008201]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 454219.595636099 | 0.201799862397169 | 0.191537048073933 | 0.464973827929265 |
| Q92546 | Q92546 | RGP1_HUMAN | RAB6A-GEF complex partner protein 2 (Retrograde Golgi transport protein RGP1 homolog) | RGP1 | negative regulation of protein catabolic process [GO:0042177]; positive regulation of GTPase activity [GO:0043547]; retrograde transport, endosome to Golgi [GO:0042147] | cytosol [GO:0005829]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; Ric1-Rgp1 guanyl-nucleotide exchange factor complex [GO:0034066]; trans-Golgi network membrane [GO:0032588] | guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] | 3337.577462577595 | -0.284108444214075 | 0.191943543288501 | 0.465761077632824 |
| Q99541 | Q99541 | PLIN2_HUMAN | Perilipin-2 (Adipophilin) (Adipose differentiation-related protein) (ADRP) | PLIN2 | cellular response to glucose starvation [GO:0042149]; lipid droplet disassembly [GO:1905691]; lipid storage [GO:0019915]; long-chain fatty acid transport [GO:0015909]; positive regulation of sequestering of triglyceride [GO:0010890]; response to organic cyclic compound [GO:0014070]; response to xenobiotic stimulus [GO:0009410] | cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; lipid droplet [GO:0005811]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | 17133.6908073897 | -0.154452939933858 | 0.192151123733089 | 0.466065182821783 | |
| Q5T653 | Q5T653 | RM02_HUMAN | Large ribosomal subunit protein uL2m (39S ribosomal protein L2, mitochondrial) (L2mt) (MRP-L2) | MRPL2 | cytoplasmic translation [GO:0002181]; mitochondrial translation [GO:0032543] | cytosolic large ribosomal subunit [GO:0022625]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 7552.484642105465 | 0.158692496989271 | 0.192270531933105 | 0.46615525628283 |
| Q8NFP7;Q96G61 | Q8NFP7 | NUD10_HUMAN | Diphosphoinositol polyphosphate phosphohydrolase 3-alpha (DIPP-3-alpha) (DIPP3-alpha) (hDIPP3alpha) (EC 3.6.1.52) (Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-alpha) (Diadenosine hexaphosphate hydrolase (AMP-forming)) (EC 3.6.1.60) (Nucleoside diphosphate-linked moiety X motif 10) (Nudix motif 10) (hAps2) | NUDT10 | adenosine 5'-(hexahydrogen pentaphosphate) catabolic process [GO:1901911]; diadenosine hexaphosphate catabolic process [GO:1901909]; diadenosine pentaphosphate catabolic process [GO:1901907]; diphosphoinositol polyphosphate metabolic process [GO:0071543] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] | bis(5'-adenosyl)-hexaphosphatase activity [GO:0034431]; bis(5'-adenosyl)-pentaphosphatase activity [GO:0034432]; diphosphoinositol-polyphosphate diphosphatase activity [GO:0008486]; endopolyphosphatase activity [GO:0000298]; metal ion binding [GO:0046872] | 12979.93503649395 | 0.516051948169413 | 0.192647714298138 | 0.466869952614734 |
| P49796 | P49796 | RGS3_HUMAN | Regulator of G-protein signaling 3 (RGP3) (RGS3) | RGS3 | G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] | cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924] | 8516.854584455636 | -0.280026374932896 | 0.192752929926577 | 0.466925224867032 |
| P31942 | P31942 | HNRH3_HUMAN | Heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) (Heterogeneous nuclear ribonucleoprotein 2H9) (hnRNP 2H9) | HNRNPH3 | epithelial cell differentiation [GO:0030855]; mRNA splicing, via spliceosome [GO:0000398]; regulation of RNA splicing [GO:0043484]; RNA processing [GO:0006396]; RNA splicing [GO:0008380] | nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681] | RNA binding [GO:0003723] | 62233.6462661969 | 0.206287654138479 | 0.193106417508659 | 0.467581607523104 |
| O95104 | O95104 | SCAF4_HUMAN | SR-related and CTD-associated factor 4 (CTD-binding SR-like protein RA4) (Splicing factor, arginine/serine-rich 15) | SCAF4 | negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled [GO:2000805] | nucleoplasm [GO:0005654]; nucleus [GO:0005634] | RNA binding [GO:0003723]; RNA polymerase II C-terminal domain phosphoserine binding [GO:1990269] | 5275.707976341135 | -0.216788288856727 | 0.193553119240221 | 0.468263011791243 |
| O43752 | O43752 | STX6_HUMAN | Syntaxin-6 | STX6 | endocytic recycling [GO:0032456]; Golgi vesicle transport [GO:0048193]; intracellular protein transport [GO:0006886]; regulation of protein localization [GO:0032880]; retrograde transport, endosome to Golgi [GO:0042147]; synaptic vesicle to endosome fusion [GO:0016189]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] | clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; SNARE complex [GO:0031201]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588] | SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905] | 20338.422798121 | 0.253487494083151 | 0.194540771575197 | 0.470250858253014 |
| P08579 | P08579 | RU2B_HUMAN | U2 small nuclear ribonucleoprotein B'' (U2 snRNP B'') | SNRPB2 | mRNA splicing, via spliceosome [GO:0000398]; U2-type prespliceosome assembly [GO:1903241] | catalytic step 2 spliceosome [GO:0071013]; cytoplasmic ribonucleoprotein granule [GO:0036464]; fibrillar center [GO:0001650]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684] | U1 snRNA binding [GO:0030619] | 24643.269157331102 | 0.273645195178751 | 0.194939014065458 | 0.471012560211037 |
| Q15050 | Q15050 | RRS1_HUMAN | Ribosome biogenesis regulatory protein homolog | RRS1 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; hematopoietic progenitor cell differentiation [GO:0002244]; mitotic metaphase chromosome alignment [GO:0007080]; protein localization to nucleolus [GO:1902570]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit biogenesis [GO:0042273] | condensed nuclear chromosome [GO:0000794]; endoplasmic reticulum [GO:0005783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, large subunit precursor [GO:0030687] | 5S rRNA binding [GO:0008097]; RNA binding [GO:0003723] | 25432.68262340725 | 0.133998482400835 | 0.195049384794743 | 0.471078352193952 |
| P04066 | P04066 | FUCO_HUMAN | Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1) | FUCA1 | fucose metabolic process [GO:0006004]; glycolipid catabolic process [GO:0019377]; glycosaminoglycan catabolic process [GO:0006027]; glycoside catabolic process [GO:0016139] | azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764] | alpha-L-fucosidase activity [GO:0004560] | 5930.958920222694 | 0.567091560805235 | 0.195534499693303 | 0.471493670355173 |
| Q9BXY0 | Q9BXY0 | MAK16_HUMAN | Protein MAK16 homolog (NNP78) (Protein RBM13) | MAK16 | maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470] | intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687] | RNA binding [GO:0003723] | 7322.7307730121 | 0.457732673339556 | 0.195455622628411 | 0.471493670355173 |
| Q9NUG6 | Q9NUG6 | PDRG1_HUMAN | p53 and DNA damage-regulated protein 1 | PDRG1 | protein folding [GO:0006457]; protein stabilization [GO:0050821] | cytoplasm [GO:0005737]; prefoldin complex [GO:0016272]; protein folding chaperone complex [GO:0101031]; RPAP3/R2TP/prefoldin-like complex [GO:1990062] | unfolded protein binding [GO:0051082] | 5571.916867705055 | 0.251329972123344 | 0.195554204965524 | 0.471493670355173 |
| Q9NZB2 | Q9NZB2 | F120A_HUMAN | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | FAM120A | cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | RNA binding [GO:0003723] | 26577.84309166375 | -0.183829182708185 | 0.195960756567859 | 0.471871503065657 | |
| Q63HN8 | Q63HN8 | RN213_HUMAN | E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213) | RNF213 | angiogenesis [GO:0001525]; defense response to bacterium [GO:0042742]; immune system process [GO:0002376]; lipid droplet formation [GO:0140042]; lipid ubiquitination [GO:0120323]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein autoubiquitination [GO:0051865]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; regulation of lipid metabolic process [GO:0019216]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511]; xenophagy [GO:0098792] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nucleolus [GO:0005730] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] | 3369.5369145173 | -0.555438781325817 | 0.195948930110715 | 0.471871503065657 |
| Q9Y3C8 | Q9Y3C8 | UFC1_HUMAN | Ubiquitin-fold modifier-conjugating enzyme 1 (Ufm1-conjugating enzyme 1) | UFC1 | brain development [GO:0007420]; protein K69-linked ufmylation [GO:1990592]; protein ufmylation [GO:0071569]; response to endoplasmic reticulum stress [GO:0034976]; reticulophagy [GO:0061709] | cytoplasm [GO:0005737]; extracellular exosome [GO:0070062] | UFM1 conjugating enzyme activity [GO:0061657]; UFM1 transferase activity [GO:0071568] | 9955.24704982122 | 0.330585447931059 | 0.195838359580828 | 0.471871503065657 |
| Q8WWM9 | Q8WWM9 | CYGB_HUMAN | Cytoglobin (Histoglobin) (HGb) (Nitric oxygen dioxygenase CYGB) (NOD) (EC 1.14.12.-) (Nitrite reductase CYGB) (EC 1.7.-.-) (Pseudoperoxidase CYGB) (EC 1.11.1.-) (Stellate cell activation-associated protein) (Superoxide dismutase CYGB) (EC 1.15.1.1) | CYGB | fatty acid oxidation [GO:0019395]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of hepatic stellate cell activation [GO:2000490]; nitric oxide catabolic process [GO:0046210]; oxygen transport [GO:0015671]; removal of superoxide radicals [GO:0019430]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleus [GO:0005634] | carbon monoxide binding [GO:0070025]; catalase activity [GO:0004096]; fatty acid peroxidase activity [GO:0047888]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; nitric oxide dioxygenase activity, heme protein as donor [GO:0141118]; nitrite reductase activity [GO:0098809]; oxidoreductase activity [GO:0016491]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]; peroxidase activity [GO:0004601]; superoxide dismutase activity [GO:0004784] | 12103.390572835051 | 0.566106650035992 | 0.196168343954531 | 0.47197020672882 |
| Q9HB21 | Q9HB21 | PKHA1_HUMAN | Pleckstrin homology domain-containing family A member 1 (PH domain-containing family A member 1) (Tandem PH domain-containing protein 1) (TAPP-1) | PLEKHA1 | androgen metabolic process [GO:0008209]; B cell receptor signaling pathway [GO:0050853]; cellular response to hydrogen peroxide [GO:0070301]; establishment of protein localization [GO:0045184]; estrogen metabolic process [GO:0008210]; face morphogenesis [GO:0060325]; Leydig cell differentiation [GO:0033327]; luteinization [GO:0001553]; multicellular organism growth [GO:0035264]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; post-embryonic development [GO:0009791]; roof of mouth development [GO:0060021]; ruffle organization [GO:0031529]; skeletal system morphogenesis [GO:0048705]; spermatogenesis [GO:0007283] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] | lipid binding [GO:0008289]; PDZ domain binding [GO:0030165]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325] | 5338.26222444215 | 0.309643773900536 | 0.196153583617919 | 0.47197020672882 |
| O14561 | O14561 | ACPM_HUMAN | Acyl carrier protein, mitochondrial (ACP) (CI-SDAP) (NADH-ubiquinone oxidoreductase 9.6 kDa subunit) | NDUFAB1 | [2Fe-2S] cluster assembly [GO:0044571]; aerobic respiration [GO:0009060]; fatty acid biosynthetic process [GO:0006633]; iron-sulfur cluster assembly [GO:0016226]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; protein lipoylation [GO:0009249]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776] | iron-sulfur cluster assembly complex [GO:1990229]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] | acyl binding [GO:0000035]; acyl carrier activity [GO:0000036]; calcium ion binding [GO:0005509]; fatty acid binding [GO:0005504]; mitochondrial large ribosomal subunit binding [GO:0140978] | 15260.2932206689 | 0.520358618738276 | 0.196258489645274 | 0.471986673314992 |
| O95140 | O95140 | MFN2_HUMAN | Mitofusin-2 (EC 3.6.5.-) (Transmembrane GTPase MFN2) | MFN2 | aerobic respiration [GO:0009060]; apoptotic process [GO:0006915]; blastocyst formation [GO:0001825]; camera-type eye morphogenesis [GO:0048593]; mitochondrial fusion [GO:0008053]; mitochondrial membrane organization [GO:0007006]; mitochondrion localization [GO:0051646]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of smooth muscle cell proliferation [GO:0048662]; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [GO:0061734]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein localization to phagophore assembly site [GO:0034497]; protein targeting to mitochondrion [GO:0006626]; response to unfolded protein [GO:0006986] | cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] | GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ubiquitin protein ligase binding [GO:0031625] | 7433.980783201925 | -0.234900212410241 | 0.197202507690721 | 0.473628042842518 |
| Q9P0K7 | Q9P0K7 | RAI14_HUMAN | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | RAI14 | cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] | anchoring junction [GO:0070161]; cell cortex [GO:0005938]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; stress fiber [GO:0001725] | 40776.75771316435 | 0.115157775812041 | 0.197163750259199 | 0.473628042842518 | |
| Q96AT9 | Q96AT9 | RPE_HUMAN | Ribulose-phosphate 3-epimerase (EC 5.1.3.1) (Ribulose-5-phosphate-3-epimerase) | RPE | carbohydrate metabolic process [GO:0005975]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, non-oxidative branch [GO:0009052] | cytosol [GO:0005829]; extracellular exosome [GO:0070062] | D-ribulose-phosphate 3-epimerase activity [GO:0004750]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803] | 14550.594719938901 | -0.902253414722014 | 0.197275358473057 | 0.473628042842518 |
| Q9Y487 | Q9Y487 | VPP2_HUMAN | V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2) | ATP6V0A2 | cellular response to increased oxygen levels [GO:0036295]; Golgi lumen acidification [GO:0061795]; immune response [GO:0006955]; intracellular iron ion homeostasis [GO:0006879]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; vacuolar acidification [GO:0007035] | acrosomal vesicle [GO:0001669]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220] | ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961] | 11713.1991343628 | -0.442657878629914 | 0.197826582012323 | 0.474640347418735 |
| Q96EK9 | Q96EK9 | KTI12_HUMAN | Protein KTI12 homolog | KTI12 | tRNA wobble uridine modification [GO:0002098] | ATP binding [GO:0005524] | 5541.424297349595 | 0.490317556149476 | 0.197907168187618 | 0.474640347418735 | |
| Q9Y221 | Q9Y221 | NIP7_HUMAN | 60S ribosome subunit biogenesis protein NIP7 homolog (KD93) (Nucleolar pre-rRNA processing protein NIP7) | NIP7 | ribosomal large subunit biogenesis [GO:0042273]; ribosome assembly [GO:0042255] | cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, large subunit precursor [GO:0030687] | RNA binding [GO:0003723] | 9335.574800160644 | -0.341865374328529 | 0.197948312910425 | 0.474640347418735 |
| Q14974 | Q14974 | IMB1_HUMAN | Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97) | KPNB1 | astral microtubule organization [GO:0030953]; establishment of mitotic spindle localization [GO:0040001]; mitotic chromosome movement towards spindle pole [GO:0007079]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle assembly [GO:0090307]; NLS-bearing protein import into nucleus [GO:0006607]; protein import into nucleus [GO:0006606]; ribosomal protein import into nucleus [GO:0006610]; RNA import into nucleus [GO:0006404] | cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; endoplasmic reticulum tubular network [GO:0071782]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; specific granule lumen [GO:0035580] | enzyme binding [GO:0019899]; Hsp90 protein binding [GO:0051879]; importin-alpha family protein binding [GO:0061676]; nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270] | 77191.06677955345 | -0.16616057920194 | 0.199011072714 | 0.476785090062377 |
| Q9NXW2 | Q9NXW2 | DJB12_HUMAN | DnaJ homolog subfamily B member 12 | DNAJB12 | cellular response to misfolded protein [GO:0071218]; chaperone cofactor-dependent protein refolding [GO:0051085]; ERAD pathway [GO:0036503]; protein-containing complex assembly [GO:0065003] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965] | Hsp70 protein binding [GO:0030544] | 7529.645302293735 | 0.42115745757998 | 0.199249210112805 | 0.477153856508518 |
| Q5H8A4 | Q5H8A4 | PIGG_HUMAN | GPI ethanolamine phosphate transferase 2 (EC 2.-.-.-) (GPI7 homolog) (hGPI7) (Phosphatidylinositol-glycan biosynthesis class G protein) (PIG-G) | PIGG | GPI anchor biosynthetic process [GO:0006506]; preassembly of GPI anchor in ER membrane [GO:0016254] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] | CP2 mannose-ethanolamine phosphotransferase activity [GO:0051267]; phosphotransferase activity, for other substituted phosphate groups [GO:0016780]; transferase activity [GO:0016740] | 8289.22983705285 | -0.188061304033958 | 0.199721681466087 | 0.478083247649703 |
| P62263 | P62263 | RS14_HUMAN | Small ribosomal subunit protein uS11 (40S ribosomal protein S14) | RPS14 | cytoplasmic translation [GO:0002181]; erythrocyte differentiation [GO:0030218]; maturation of SSU-rRNA [GO:0030490]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]; small-subunit processome [GO:0032040] | mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; translation regulator activity [GO:0045182] | 333024.60095933 | 0.250117984562885 | 0.199937608610067 | 0.478276459800623 |
| Q71UM5 | Q71UM5 | RS27L_HUMAN | Ribosomal protein eS27-like (40S ribosomal protein S27-like) (Small ribosomal subunit protein eS27-like) | RPS27L | activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; positive regulation of translation [GO:0045727]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] | cytosolic small ribosomal subunit [GO:0022627]; nucleus [GO:0005634] | cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; translation activator activity [GO:0008494] | 257209.62937409803 | 0.184145503402035 | 0.199971220131958 | 0.478276459800623 |
| P42226 | P42226 | STAT6_HUMAN | Signal transducer and activator of transcription 6 (IL-4 Stat) | STAT6 | cellular response to hydrogen peroxide [GO:0070301]; cellular response to reactive nitrogen species [GO:1902170]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; interleukin-4-mediated signaling pathway [GO:0035771]; isotype switching to IgE isotypes [GO:0048289]; mammary gland epithelial cell proliferation [GO:0033598]; mammary gland morphogenesis [GO:0060443]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type 2 immune response [GO:0002829]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of isotype switching to IgE isotypes [GO:0048295]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of cell population proliferation [GO:0042127]; regulation of mast cell proliferation [GO:0070666]; regulation of transcription by RNA polymerase II [GO:0006357]; response to peptide hormone [GO:0043434]; signal transduction [GO:0007165]; T-helper 1 cell lineage commitment [GO:0002296] | chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575] | DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein phosphatase binding [GO:0019903]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coactivator binding [GO:0001223] | 15746.64960411875 | 0.173432381484175 | 0.200302663590595 | 0.478745765496255 |
| P62699 | P62699 | YPEL5_HUMAN | Protein yippee-like 5 | YPEL5 | cell population proliferation [GO:0008283] | centrosome [GO:0005813]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; midbody [GO:0030496]; mitotic spindle pole [GO:0097431]; nucleus [GO:0005634]; tertiary granule lumen [GO:1904724]; ubiquitin ligase complex [GO:0000151] | metal ion binding [GO:0046872] | 13335.721911254499 | 0.346184552752912 | 0.200336429578472 | 0.478745765496255 |
| O75044 | O75044 | SRGP2_HUMAN | SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) | SRGAP2 | actin filament severing [GO:0051014]; dendritic spine development [GO:0060996]; excitatory synapse assembly [GO:1904861]; extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration [GO:0021816]; filopodium assembly [GO:0046847]; inhibitory synapse assembly [GO:1904862]; lamellipodium assembly involved in ameboidal cell migration [GO:0003363]; negative regulation of cell migration [GO:0030336]; negative regulation of neuron migration [GO:2001223]; neuron projection morphogenesis [GO:0048812]; positive regulation of GTPase activity [GO:0043547]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; substrate adhesion-dependent cell spreading [GO:0034446] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine head [GO:0044327]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211] | GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267] | 8130.98154747673 | -0.239422714690131 | 0.200552506110887 | 0.478999110789616 |
| Q9BU02 | Q9BU02 | THTPA_HUMAN | Thiamine-triphosphatase (ThTPase) (EC 3.6.1.28) | THTPA | dephosphorylation [GO:0016311]; generation of precursor metabolites and energy [GO:0006091]; thiamine diphosphate biosynthetic process [GO:0009229]; thiamine diphosphate metabolic process [GO:0042357]; thiamine metabolic process [GO:0006772] | cytosol [GO:0005829] | hydrolase activity [GO:0016787]; magnesium ion binding [GO:0000287]; thiamine triphosphate phosphatase activity [GO:0050333] | 15078.0804624512 | -0.177564729792237 | 0.200675528034497 | 0.478999110789616 |
| P28074 | P28074 | PSB5_HUMAN | Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit MB1) (Proteasome subunit X) | PSMB5 | proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; proteolysis [GO:0006508]; response to oxidative stress [GO:0006979] | centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774] | endopeptidase activity [GO:0004175]; peptidase activity [GO:0008233]; threonine-type endopeptidase activity [GO:0004298] | 172250.688660533 | 0.157985660719374 | 0.200899177694083 | 0.479281996132494 |
| O60725 | O60725 | ICMT_HUMAN | Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) (Isoprenylcysteine carboxylmethyltransferase) (Prenylated protein carboxyl methyltransferase) (PPMT) (Prenylcysteine carboxyl methyltransferase) (pcCMT) | ICMT | C-terminal protein methylation [GO:0006481]; protein modification process [GO:0036211]; protein targeting to membrane [GO:0006612]; S-adenosylhomocysteine metabolic process [GO:0046498]; S-adenosylmethioninamine metabolic process [GO:0046499] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] | protein C-terminal carboxyl O-methyltransferase activity [GO:0003880]; protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity [GO:0004671] | 5145.56580160681 | -0.752697914176268 | 0.201967174817139 | 0.481627109643902 |
| P24844 | P24844 | MYL9_HUMAN | Myosin regulatory light polypeptide 9 (20 kDa myosin light chain) (LC20) (MLC-2C) (Myosin RLC) (Myosin regulatory light chain 2, smooth muscle isoform) (Myosin regulatory light chain 9) (Myosin regulatory light chain MRLC1) | MYL9 | myofibril assembly [GO:0030239]; platelet aggregation [GO:0070527]; regulation of muscle contraction [GO:0006937] | cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; stress fiber [GO:0001725]; Z disc [GO:0030018] | calcium ion binding [GO:0005509]; myosin heavy chain binding [GO:0032036]; structural constituent of muscle [GO:0008307] | 254823.45972827252 | -0.259628111517918 | 0.202281344760767 | 0.482173369547542 |
| P41208 | P41208 | CETN2_HUMAN | Centrin-2 (Caltractin isoform 1) | CETN2 | cell division [GO:0051301]; centriole replication [GO:0007099]; mitotic cell cycle [GO:0000278]; mRNA transport [GO:0051028]; nucleotide-excision repair [GO:0006289]; protein transport [GO:0015031]; regulation of cytokinesis [GO:0032465]; spermatogenesis [GO:0007283] | 9+2 motile cilium [GO:0097729]; apical part of cell [GO:0045177]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; photoreceptor connecting cilium [GO:0032391]; transcription export complex 2 [GO:0070390]; XPC complex [GO:0071942] | calcium ion binding [GO:0005509]; G-protein beta/gamma-subunit complex binding [GO:0031683]; heterotrimeric G-protein binding [GO:0032795]; microtubule binding [GO:0008017] | 20795.9246119007 | 0.330555546989948 | 0.202666104639485 | 0.482714636689383 |
| Q07352 | Q07352 | TISB_HUMAN | mRNA decay activator protein ZFP36L1 (Butyrate response factor 1) (EGF-response factor 1) (ERF-1) (TPA-induced sequence 11b) (Zinc finger protein 36, C3H1 type-like 1) (ZFP36-like 1) | ZFP36L1 | 3'-UTR-mediated mRNA destabilization [GO:0061158]; apoptotic process [GO:0006915]; cell population proliferation [GO:0008283]; cellular response to cAMP [GO:0071320]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to raffinose [GO:0097403]; cellular response to salt stress [GO:0071472]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; chorio-allantoic fusion [GO:0060710]; ERK1 and ERK2 cascade [GO:0070371]; heart development [GO:0007507]; MAPK cascade [GO:0000165]; mesendoderm development [GO:0048382]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; multicellular organism growth [GO:0035264]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of mitotic cell cycle phase transition [GO:1901991]; neural tube development [GO:0021915]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, deadenylation-independent decay [GO:0031086]; p38MAPK cascade [GO:0038066]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of intracellular mRNA localization [GO:1904582]; positive regulation of monocyte differentiation [GO:0045657]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; proepicardium development [GO:0003342]; regulation of B cell differentiation [GO:0045577]; regulation of gene expression [GO:0010468]; regulation of keratinocyte apoptotic process [GO:1902172]; regulation of keratinocyte differentiation [GO:0045616]; regulation of keratinocyte proliferation [GO:0010837]; regulation of mRNA 3'-end processing [GO:0031440]; regulation of mRNA stability [GO:0043488]; regulation of myoblast differentiation [GO:0045661]; regulation of stem cell proliferation [GO:0072091]; regulation of translation [GO:0006417]; response to wounding [GO:0009611]; spongiotrophoblast layer development [GO:0060712]; T cell differentiation in thymus [GO:0033077]; vasculogenesis [GO:0001570] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904] | 14-3-3 protein binding [GO:0071889]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] | 18789.3675814656 | 0.54087416397277 | 0.202913628489978 | 0.483070848329502 |
| P20020 | P20020 | AT2B1_HUMAN | Plasma membrane calcium-transporting ATPase 1 (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 1) (PMCA1) (Plasma membrane calcium pump isoform 1) | ATP2B1 | calcium ion export across plasma membrane [GO:1990034]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cytokine production [GO:0001818]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; positive regulation of bone mineralization [GO:0030501]; positive regulation of calcium ion transport [GO:0051928]; regulation of blood pressure [GO:0008217]; regulation of cardiac conduction [GO:1903779]; regulation of cellular response to insulin stimulus [GO:1900076]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of vascular associated smooth muscle contraction [GO:0003056] | basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; immunological synapse [GO:0001772]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion transmembrane transporter activity [GO:0015085]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; molecular function inhibitor activity [GO:0140678]; P-type calcium transporter activity [GO:0005388]; PDZ domain binding [GO:0030165] | 37201.98576251515 | 0.170944991246884 | 0.203247004895572 | 0.483661289264305 |
| O75381 | O75381 | PEX14_HUMAN | Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) | PEX14 | cellular response to reactive oxygen species [GO:0034614]; microtubule anchoring [GO:0034453]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein binding [GO:0032091]; peroxisome organization [GO:0007031]; peroxisome transport along microtubule [GO:0036250]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, docking [GO:0016560]; protein import into peroxisome matrix, substrate release [GO:0044721]; protein import into peroxisome matrix, translocation [GO:0016561]; protein-containing complex assembly [GO:0065003] | cytosol [GO:0005829]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nucleus [GO:0005634]; peroxisomal importomer complex [GO:1990429]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991] | beta-tubulin binding [GO:0048487]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; protein transmembrane transporter activity [GO:0008320]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor binding [GO:0005102]; transcription corepressor activity [GO:0003714] | 14955.061072540251 | 0.197307944737939 | 0.204019966926616 | 0.485296865073975 |
| P11387 | P11387 | TOP1_HUMAN | DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I) | TOP1 | chromatin remodeling [GO:0006338]; chromosome segregation [GO:0007059]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; DNA replication [GO:0006260]; DNA topological change [GO:0006265]; embryonic cleavage [GO:0040016]; peptidyl-serine phosphorylation [GO:0018105]; phosphorylation [GO:0016310]; programmed cell death [GO:0012501]; response to xenobiotic stimulus [GO:0009410] | chromosome [GO:0005694]; fibrillar center [GO:0001650]; male germ cell nucleus [GO:0001673]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perikaryon [GO:0043204]; protein-DNA complex [GO:0032993] | ATP binding [GO:0005524]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA binding, bending [GO:0008301]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; double-stranded DNA binding [GO:0003690]; protein domain specific binding [GO:0019904]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; single-stranded DNA binding [GO:0003697]; supercoiled DNA binding [GO:0097100] | 9716.316623671926 | 0.106290635159881 | 0.205172042878736 | 0.48783247794835 |
| L0R819 | L0R819 | ASURF_HUMAN | ASNSD1 upstream open reading frame protein (ASNSD1 small/short open reading frame-encoded polypeptide) (ASNSD1-SEP) | ASDURF | protein stabilization [GO:0050821] | cytoplasm [GO:0005737]; RPAP3/R2TP/prefoldin-like complex [GO:1990062] | 13673.7698663288 | 0.294999046730289 | 0.205581744919992 | 0.488601579998606 | |
| Q99447 | Q99447 | PCY2_HUMAN | Ethanolamine-phosphate cytidylyltransferase (EC 2.7.7.14) (CTP:phosphoethanolamine cytidylyltransferase) (Phosphorylethanolamine transferase) | PCYT2 | phosphatidylethanolamine biosynthetic process [GO:0006646]; phospholipid biosynthetic process [GO:0008654] | cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789] | ethanolamine-phosphate cytidylyltransferase activity [GO:0004306] | 22238.254997834352 | 0.168266235015806 | 0.20593396920447 | 0.48923348826521 |
| Q5JVF3 | Q5JVF3 | PCID2_HUMAN | PCI domain-containing protein 2 (CSN12-like protein) | PCID2 | heterochromatin organization [GO:0070828]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of lymphoid progenitor cell differentiation [GO:1905457]; negative regulation of transcription initiation by RNA polymerase II [GO:0060633]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000973]; protein transport [GO:0015031]; regulation of mRNA stability [GO:0043488]; spleen development [GO:0048536]; transcription elongation by RNA polymerase II [GO:0006368] | cytoplasm [GO:0005737]; nuclear pore nuclear basket [GO:0044615]; nucleus [GO:0005634]; transcription export complex 2 [GO:0070390] | double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723] | 5432.066018797364 | -0.231922677446405 | 0.20623621184367 | 0.489746176155169 |
| Q6ZMI0 | Q6ZMI0 | PPR21_HUMAN | Protein phosphatase 1 regulatory subunit 21 (Coiled-coil domain-containing protein 128) (Ferry endosomal RAB5 effector complex subunit 2) (Fy-2) (KLRAQ motif-containing protein 1) | PPP1R21 | early endosome [GO:0005769]; membrane [GO:0016020] | 8585.884883565885 | -0.323882401572085 | 0.206456579917378 | 0.490064089573466 | ||
| Q8WW12 | Q8WW12 | PCNP_HUMAN | PEST proteolytic signal-containing nuclear protein (PCNP) (PEST-containing nuclear protein) | PCNP | cell cycle [GO:0007049]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] | nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | 121384.95883896 | 0.294975782461568 | 0.207067580034624 | 0.491102933644277 | |
| Q99719 | Q99719 | SEPT5_HUMAN | Septin-5 (Cell division control-related protein 1) (CDCrel-1) (Peanut-like protein 1) | SEPTIN5 | adult behavior [GO:0030534]; cytoskeleton-dependent cytokinesis [GO:0061640]; regulation of exocytosis [GO:0017157]; regulation of synaptic vesicle exocytosis [GO:2000300]; social behavior [GO:0035176]; synaptic vesicle targeting [GO:0016080] | cell division site [GO:0032153]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]; septin complex [GO:0031105]; septin ring [GO:0005940]; synaptic vesicle [GO:0008021] | GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; structural molecule activity [GO:0005198] | 14463.693811726149 | -0.536118376367125 | 0.207238032041019 | 0.491301543742432 |
| Q9NX14 | Q9NX14 | NDUBB_HUMAN | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (Complex I-ESSS) (CI-ESSS) (NADH-ubiquinone oxidoreductase ESSS subunit) (Neuronal protein 17.3) (Np17.3) (p17.3) | NDUFB11 | aerobic respiration [GO:0009060]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776] | mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739] | 25326.8404523453 | 0.270925971078944 | 0.207872944639775 | 0.49198333514159 | |
| P46934 | P46934 | NEDD4_HUMAN | E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4) | NEDD4 | cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; formation of structure involved in a symbiotic process [GO:0044111]; glucocorticoid receptor signaling pathway [GO:0042921]; innate immune response [GO:0045087]; lysosomal transport [GO:0007041]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; negative regulation of sodium ion transport [GO:0010766]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; neuromuscular junction development [GO:0007528]; neuron projection development [GO:0031175]; positive regulation of nucleocytoplasmic transport [GO:0046824]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein catabolic process [GO:0045732]; progesterone receptor signaling pathway [GO:0050847]; protein K63-linked ubiquitination [GO:0070534]; protein targeting to lysosome [GO:0006622]; protein ubiquitination [GO:0016567]; receptor catabolic process [GO:0032801]; receptor internalization [GO:0031623]; regulation of dendrite morphogenesis [GO:0048814]; regulation of macroautophagy [GO:0016241]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of potassium ion transmembrane transporter activity [GO:1901016]; regulation of synapse organization [GO:0050807]; response to calcium ion [GO:0051592]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding [GO:0046755] | apicolateral plasma membrane [GO:0016327]; cell cortex [GO:0005938]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ubiquitin ligase complex [GO:0000151] | beta-2 adrenergic receptor binding [GO:0031698]; enzyme binding [GO:0019899]; phosphoserine residue binding [GO:0050815]; phosphothreonine residue binding [GO:0050816]; proline-rich region binding [GO:0070064]; protein domain specific binding [GO:0019904]; RNA polymerase binding [GO:0070063]; sodium channel inhibitor activity [GO:0019871]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630] | 4237.80610420652 | 0.22411138692986 | 0.20780499457892 | 0.49198333514159 |
| Q9UBE0 | Q9UBE0 | SAE1_HUMAN | SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed] | SAE1 | positive regulation of protein sumoylation [GO:0033235]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein sumoylation [GO:0016925] | cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SUMO activating enzyme complex [GO:0031510] | ATP-dependent protein binding [GO:0043008]; enzyme activator activity [GO:0008047]; protein heterodimerization activity [GO:0046982]; small protein activating enzyme binding [GO:0044388]; SUMO activating enzyme activity [GO:0019948]; ubiquitin activating enzyme activity [GO:0004839] | 28503.78231702705 | 0.155229624477546 | 0.207835738160889 | 0.49198333514159 |
| P43005 | P43005 | EAA3_HUMAN | Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Neuronal and epithelial glutamate transporter) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1) | SLC1A1 | adult behavior [GO:0030534]; behavioral fear response [GO:0001662]; blood vessel morphogenesis [GO:0048514]; brain development [GO:0007420]; cellular response to ammonium ion [GO:0071242]; cellular response to bisphenol A [GO:1903926]; cellular response to cocaine [GO:0071314]; cellular response to mercury ion [GO:0071288]; cellular response to organic cyclic compound [GO:0071407]; cellular response to oxidative stress [GO:0034599]; chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; conditioned place preference [GO:1990708]; cysteine transport [GO:0042883]; cytokine-mediated signaling pathway [GO:0019221]; D-aspartate import across plasma membrane [GO:0070779]; D-aspartate transmembrane transport [GO:0070777]; dopamine metabolic process [GO:0042417]; dopamine receptor signaling pathway [GO:0007212]; gene expression [GO:0010467]; glutamate receptor signaling pathway [GO:0007215]; glutathione biosynthetic process [GO:0006750]; grooming behavior [GO:0007625]; heart contraction [GO:0060047]; intracellular glutamate homeostasis [GO:0090461]; intracellular zinc ion homeostasis [GO:0006882]; L-aspartate import across plasma membrane [GO:0140009]; L-aspartate transmembrane transport [GO:0070778]; L-glutamate import [GO:0051938]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]; locomotory behavior [GO:0007626]; long-term synaptic potentiation [GO:0060291]; maintenance of blood-brain barrier [GO:0035633]; memory [GO:0007613]; monoatomic ion transport [GO:0006811]; motor behavior [GO:0061744]; motor neuron apoptotic process [GO:0097049]; negative regulation of neuron apoptotic process [GO:0043524]; neurogenesis [GO:0022008]; neurotransmitter receptor transport to plasma membrane [GO:0098877]; neurotransmitter transport [GO:0006836]; positive regulation of heart rate [GO:0010460]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of protein phosphorylation [GO:0001932]; regulation of protein targeting to membrane [GO:0090313]; response to amphetamine [GO:0001975]; response to anesthetic [GO:0072347]; response to axon injury [GO:0048678]; response to decreased oxygen levels [GO:0036293]; response to morphine [GO:0043278]; response to xenobiotic stimulus [GO:0009410]; retina layer formation [GO:0010842]; righting reflex [GO:0060013]; superoxide metabolic process [GO:0006801]; synapse organization [GO:0050808]; transepithelial transport [GO:0070633]; transport across blood-brain barrier [GO:0150104]; zinc ion transmembrane transport [GO:0071577] | apical dendrite [GO:0097440]; apical plasma membrane [GO:0016324]; asymmetric synapse [GO:0032279]; axon [GO:0030424]; axon terminus [GO:0043679]; cell periphery [GO:0071944]; cell surface [GO:0009986]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; distal dendrite [GO:0150002]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; glial cell projection [GO:0097386]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; perisynaptic space [GO:0099544]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; proximal dendrite [GO:1990635]; recycling endosome membrane [GO:0055038]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic cleft [GO:0043083] | chloride transmembrane transporter activity [GO:0015108]; cysteine transmembrane transporter activity [GO:0033229]; D-aspartate transmembrane transporter activity [GO:0140010]; glutamate binding [GO:0016595]; glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; identical protein binding [GO:0042802]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamate transmembrane transporter activity [GO:0005313]; metal ion binding [GO:0046872]; monoatomic anion channel activity [GO:0005253] | 11151.407061128699 | 0.395732194868134 | 0.20764260948101 | 0.49198333514159 |
| P02649 | P02649 | APOE_HUMAN | Apolipoprotein E (Apo-E) | APOE | acylglycerol homeostasis [GO:0055090]; AMPA glutamate receptor clustering [GO:0097113]; amyloid precursor protein metabolic process [GO:0042982]; artery morphogenesis [GO:0048844]; cholesterol catabolic process [GO:0006707]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; chylomicron remnant clearance [GO:0034382]; cytoskeleton organization [GO:0007010]; fatty acid homeostasis [GO:0055089]; G protein-coupled receptor signaling pathway [GO:0007186]; gene expression [GO:0010467]; high-density lipoprotein particle assembly [GO:0034380]; high-density lipoprotein particle clearance [GO:0034384]; high-density lipoprotein particle remodeling [GO:0034375]; intermediate-density lipoprotein particle clearance [GO:0071831]; intracellular calcium ion homeostasis [GO:0006874]; intracellular transport [GO:0046907]; lipid transport involved in lipid storage [GO:0010877]; lipoprotein biosynthetic process [GO:0042158]; lipoprotein catabolic process [GO:0042159]; locomotory exploration behavior [GO:0035641]; long-chain fatty acid transport [GO:0015909]; long-term memory [GO:0007616]; low-density lipoprotein particle remodeling [GO:0034374]; maintenance of location in cell [GO:0051651]; melanosome organization [GO:0032438]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of blood coagulation [GO:0030195]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cholesterol biosynthetic process [GO:0045541]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of neuron projection development [GO:0010977]; negative regulation of platelet activation [GO:0010544]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of protein secretion [GO:0050709]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of triglyceride metabolic process [GO:0090209]; neuron projection development [GO:0031175]; nitric oxide-cGMP-mediated signaling pathway [GO:0038060]; NMDA glutamate receptor clustering [GO:0097114]; phospholipid efflux [GO:0033700]; positive regulation by host of viral process [GO:0044794]; positive regulation of amyloid fibril formation [GO:1905908]; positive regulation of amyloid-beta clearance [GO:1900223]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol metabolic process [GO:0090205]; positive regulation of CoA-transferase activity [GO:1905920]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of dendritic spine maintenance [GO:1902952]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endocytosis [GO:0045807]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of heparan sulfate proteoglycan binding [GO:1905860]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of lipid transport across blood-brain barrier [GO:1903002]; positive regulation of low-density lipoprotein particle receptor catabolic process [GO:0032805]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of neuron projection development [GO:0010976]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of phospholipid efflux [GO:1902995]; protein import [GO:0017038]; receptor-mediated endocytosis [GO:0006898]; regulation of amyloid fibril formation [GO:1905906]; regulation of amyloid precursor protein catabolic process [GO:1902991]; regulation of amyloid-beta clearance [GO:1900221]; regulation of axon extension [GO:0030516]; regulation of behavioral fear response [GO:2000822]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of cellular response to very-low-density lipoprotein particle stimulus [GO:1905890]; regulation of cholesterol metabolic process [GO:0090181]; regulation of innate immune response [GO:0045088]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein metabolic process [GO:0051246]; regulation of protein-containing complex assembly [GO:0043254]; response to caloric restriction [GO:0061771]; response to dietary excess [GO:0002021]; response to reactive oxygen species [GO:0000302]; reverse cholesterol transport [GO:0043691]; synaptic transmission, cholinergic [GO:0007271]; triglyceride homeostasis [GO:0070328]; triglyceride metabolic process [GO:0006641]; triglyceride-rich lipoprotein particle clearance [GO:0071830]; vasodilation [GO:0042311]; very-low-density lipoprotein particle clearance [GO:0034447]; very-low-density lipoprotein particle remodeling [GO:0034372]; virion assembly [GO:0019068] | blood microparticle [GO:0072562]; chylomicron [GO:0042627]; chylomicron remnant [GO:0034360]; clathrin-coated endocytic vesicle membrane [GO:0030669]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; discoidal high-density lipoprotein particle [GO:0034365]; early endosome [GO:0005769]; endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; high-density lipoprotein particle [GO:0034364]; intermediate-density lipoprotein particle [GO:0034363]; lipoprotein particle [GO:1990777]; low-density lipoprotein particle [GO:0034362]; melanosome [GO:0042470]; membrane [GO:0016020]; multivesicular body, internal vesicle [GO:0097487]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synaptic cleft [GO:0043083]; very-low-density lipoprotein particle [GO:0034361] | amyloid-beta binding [GO:0001540]; antioxidant activity [GO:0016209]; cholesterol transfer activity [GO:0120020]; enzyme binding [GO:0019899]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; lipid transporter activity [GO:0005319]; lipoprotein particle binding [GO:0071813]; low-density lipoprotein particle receptor binding [GO:0050750]; metal chelating activity [GO:0046911]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228]; phospholipid binding [GO:0005543]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; signaling receptor binding [GO:0005102]; structural molecule activity [GO:0005198]; tau protein binding [GO:0048156]; very-low-density lipoprotein particle receptor binding [GO:0070326] | 56017.150384144246 | 0.352481128857095 | 0.208470977855115 | 0.493192718382916 |
| Q08722 | Q08722 | CD47_HUMAN | Leukocyte surface antigen CD47 (Antigenic surface determinant protein OA3) (Integrin-associated protein) (IAP) (Protein MER6) (CD antigen CD47) | CD47 | angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; ATP export [GO:1904669]; cell migration [GO:0016477]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-12 [GO:0071349]; cellular response to type II interferon [GO:0071346]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of phagocytosis [GO:0050765]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of inflammatory response [GO:0050729]; positive regulation of monocyte extravasation [GO:2000439]; positive regulation of phagocytosis [GO:0050766]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of T cell activation [GO:0050870]; regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060368]; regulation of interleukin-10 production [GO:0032653]; regulation of interleukin-12 production [GO:0032655]; regulation of interleukin-6 production [GO:0032675]; regulation of nitric oxide biosynthetic process [GO:0045428]; regulation of tumor necrosis factor production [GO:0032680]; regulation of type II interferon production [GO:0032649] | cell surface [GO:0009986]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821] | cell-cell adhesion mediator activity [GO:0098632]; protein binding involved in heterotypic cell-cell adhesion [GO:0086080]; thrombospondin receptor activity [GO:0070053] | 85269.6260310785 | 0.183527501382036 | 0.208747400702459 | 0.493640556085197 |
| O96008 | O96008 | TOM40_HUMAN | Mitochondrial import receptor subunit TOM40 homolog (Protein Haymaker) (Translocase of outer membrane 40 kDa subunit homolog) (p38.5) | TOMM40 | monoatomic ion transport [GO:0006811]; protein import into mitochondrial matrix [GO:0030150]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein targeting to mitochondrion [GO:0006626] | cytosol [GO:0005829]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane [GO:0044233]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; pore complex [GO:0046930]; TOM complex [GO:0140596] | porin activity [GO:0015288]; protein transmembrane transporter activity [GO:0008320] | 12679.4496769738 | -0.12003229737151 | 0.209437455857778 | 0.494859309795734 |
| O75348 | O75348 | VATG1_HUMAN | V-type proton ATPase subunit G 1 (V-ATPase subunit G 1) (V-ATPase 13 kDa subunit 1) (Vacuolar proton pump subunit G 1) (Vacuolar proton pump subunit M16) | ATP6V1G1 | cellular response to increased oxygen levels [GO:0036295]; intracellular iron ion homeostasis [GO:0006879]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401] | apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]; transmembrane transporter complex [GO:1902495]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221] | ATP hydrolysis activity [GO:0016887]; ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961] | 171335.169319842 | 0.209160533897599 | 0.209621640484962 | 0.495088042929468 |
| Q92530 | Q92530 | PSMF1_HUMAN | Proteasome inhibitor PI31 subunit (hPI31) | PSMF1 | negative regulation of proteasomal protein catabolic process [GO:1901799]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; ubiquitin-dependent protein catabolic process [GO:0006511] | cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; proteasome core complex [GO:0005839] | endopeptidase inhibitor activity [GO:0004866]; proteasome binding [GO:0070628]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] | 60268.73372155455 | 0.150768957249628 | 0.209889398249179 | 0.495449906103248 |
| Q08AE8 | Q08AE8 | SPIR1_HUMAN | Protein spire homolog 1 (Spir-1) | SPIRE1 | actin cytoskeleton organization [GO:0030036]; actin filament network formation [GO:0051639]; actin filament polymerization [GO:0030041]; actin nucleation [GO:0045010]; cleavage furrow formation [GO:0036089]; establishment of meiotic spindle localization [GO:0051295]; formin-nucleated actin cable assembly [GO:0070649]; Golgi vesicle transport [GO:0048193]; innate immune response [GO:0045087]; intracellular transport [GO:0046907]; polar body extrusion after meiotic divisions [GO:0040038]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of mitochondrial fission [GO:0090141]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] | cell cortex [GO:0005938]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] | actin binding [GO:0003779] | 12903.450145192899 | 0.26684085882249 | 0.209949739596523 | 0.495449906103248 |
| O43181 | O43181 | NDUS4_HUMAN | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (Complex I-18 kDa) (CI-18 kDa) (Complex I-AQDQ) (CI-AQDQ) (NADH-ubiquinone oxidoreductase 18 kDa subunit) | NDUFS4 | aerobic respiration [GO:0009060]; brain development [GO:0007420]; cellular respiration [GO:0045333]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; positive regulation of fibroblast proliferation [GO:0048146]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; reactive oxygen species metabolic process [GO:0072593]; regulation of protein phosphorylation [GO:0001932]; response to cAMP [GO:0051591] | mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739] | NADH dehydrogenase (ubiquinone) activity [GO:0008137] | 52520.0554125162 | 0.339037590641824 | 0.210517356913849 | 0.496582574635249 |
| O00459 | O00459 | P85B_HUMAN | Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta) | PIK3R2 | B cell differentiation [GO:0030183]; cellular response to insulin stimulus [GO:0032869]; immune response [GO:0006955]; insulin receptor signaling pathway [GO:0008286]; intracellular glucose homeostasis [GO:0001678]; negative regulation of MAPK cascade [GO:0043409]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of cell adhesion [GO:0045785]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein transport [GO:0015031]; regulation of actin filament polymerization [GO:0030833]; regulation of autophagy [GO:0010506]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of stress fiber assembly [GO:0051492]; response to endoplasmic reticulum stress [GO:0034976]; T cell differentiation [GO:0030217] | cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943] | 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; phosphotyrosine residue binding [GO:0001784]; protein heterodimerization activity [GO:0046982]; protein phosphatase binding [GO:0019903]; receptor tyrosine kinase binding [GO:0030971] | 2661.32848252688 | -0.786620570468316 | 0.210629250628848 | 0.496639756164401 |
| Q9H1E3 | Q9H1E3 | NUCKS_HUMAN | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1) | NUCKS1 | cellular response to X-ray [GO:0071481]; chromatin organization [GO:0006325]; double-strand break repair via homologous recombination [GO:0000724]; gene conversion [GO:0035822]; interstrand cross-link repair [GO:0036297]; intracellular glucose homeostasis [GO:0001678]; modulation by host of RNA binding by virus [GO:1990968]; modulation by host of viral genome replication [GO:0044827]; modulation by host of viral RNA-binding transcription factor activity [GO:1990969]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of insulin receptor signaling pathway [GO:0046626]; replication fork processing [GO:0031297] | chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; transcription coactivator activity [GO:0003713] | 7860.3333046928055 | 0.705149253649537 | 0.210854927429138 | 0.496965066062186 |
| Q13541 | Q13541 | 4EBP1_HUMAN | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) | EIF4EBP1 | G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; positive regulation of mitotic cell cycle [GO:0045931]; TOR signaling [GO:0031929] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] | eukaryotic initiation factor 4E binding [GO:0008190]; translation initiation factor binding [GO:0031369]; translation repressor activity [GO:0030371] | 49774.00721974055 | 0.35650923113924 | 0.211171367282272 | 0.497443453835286 |
| Q5BKZ1 | Q5BKZ1 | ZN326_HUMAN | DBIRD complex subunit ZNF326 (Zinc finger protein 326) (Zinc finger protein interacting with mRNPs and DBC1) | ZNF326 | mRNA processing [GO:0006397]; regulation of DNA-templated transcription elongation [GO:0032784]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] | DBIRD complex [GO:0044609]; intracellular membrane-bounded organelle [GO:0043231]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | DNA binding [GO:0003677]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA polymerase II complex binding [GO:0000993] | 16610.46583341015 | 0.107359029220492 | 0.211233489221267 | 0.497443453835286 |
| P52298 | P52298 | NCBP2_HUMAN | Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (Cell proliferation-inducing gene 55 protein) (NCBP 20 kDa subunit) (CBP20) (NCBP-interacting protein 1) (NIP1) | NCBP2 | alternative mRNA splicing, via spliceosome [GO:0000380]; cap-dependent translational initiation [GO:0002191]; histone mRNA metabolic process [GO:0008334]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; mRNA 3'-end processing [GO:0031124]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA export from nucleus [GO:0006406]; mRNA metabolic process [GO:0016071]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transcription by RNA polymerase II [GO:0042789]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of RNA export from nucleus [GO:0046833]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; primary miRNA processing [GO:0031053]; regulation of translational initiation [GO:0006446]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; RNA splicing [GO:0008380]; snRNA export from nucleus [GO:0006408] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear cap binding complex [GO:0005846]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA cap binding complex [GO:0034518] | DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; snRNA binding [GO:0017069] | 50380.85852213185 | 0.36202938853843 | 0.212197464482798 | 0.499505955030965 |
| Q7Z3E2 | Q7Z3E2 | CC186_HUMAN | Coiled-coil domain-containing protein 186 (CTCL tumor antigen HD-CL-01/L14-2) | CCDC186 | insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; response to bacterium [GO:0009617]; vesicle cytoskeletal trafficking [GO:0099518] | trans-Golgi network [GO:0005802] | small GTPase binding [GO:0031267] | 2582.72312654857 | -0.209663390765491 | 0.212501352671477 | 0.500013564882305 |
| O95232 | O95232 | LC7L3_HUMAN | Luc7-like protein 3 (Cisplatin resistance-associated-overexpressed protein) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18) (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) | LUC7L3 | mRNA splice site recognition [GO:0006376]; RNA splicing [GO:0008380] | nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004] | DNA binding [GO:0003677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] | 10452.797894971 | 0.311197576062903 | 0.212912758826537 | 0.500565847100066 |
| Q8N4V1 | Q8N4V1 | EMC5_HUMAN | ER membrane protein complex subunit 5 (Membrane magnesium transporter 1) (Transmembrane protein 32) | MMGT1 | copper ion transport [GO:0006825]; magnesium ion transport [GO:0015693]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816] | early endosome [GO:0005769]; early endosome membrane [GO:0031901]; EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886] | cobalt ion transmembrane transporter activity [GO:0015087]; ferrous iron transmembrane transporter activity [GO:0015093]; inorganic cation transmembrane transporter activity [GO:0022890]; magnesium ion transmembrane transporter activity [GO:0015095] | 18351.44714091495 | -0.286130364489211 | 0.213447178370931 | 0.501406182690586 |
| P82663 | P82663 | RT25_HUMAN | Small ribosomal subunit protein mS25 (28S ribosomal protein S25, mitochondrial) (MRP-S25) (S25mt) | MRPS25 | mitochondrial translation [GO:0032543] | mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] | structural constituent of ribosome [GO:0003735] | 13371.60225557355 | 0.318361983858555 | 0.21461481692621 | 0.503330575259874 |
| Q92545 | Q92545 | TM131_HUMAN | Transmembrane protein 131 (Protein RW1) | TMEM131 | membrane [GO:0016020] | 7621.165496730206 | 0.243240918665409 | 0.214621720760299 | 0.503330575259874 | ||
| O60507 | O60507 | TPST1_HUMAN | Protein-tyrosine sulfotransferase 1 (EC 2.8.2.20) (Tyrosylprotein sulfotransferase 1) (TPST-1) | TPST1 | 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; post-translational protein modification [GO:0043687] | Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] | protein homodimerization activity [GO:0042803]; protein-tyrosine sulfotransferase activity [GO:0008476] | 9557.95865332722 | -0.163678103087844 | 0.214483054054946 | 0.503330575259874 |
| Q9Y676 | Q9Y676 | RT18B_HUMAN | Small ribosomal subunit protein mS40 (28S ribosomal protein S18-2, mitochondrial) (MRP-S18-2) (28S ribosomal protein S18b, mitochondrial) (MRP-S18-b) (Mrps18-b) (S18mt-b) (Small ribosomal subunit protein bS18b) | MRPS18B | mitochondrial translation [GO:0032543]; translation [GO:0006412] | cell junction [GO:0030054]; mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] | structural constituent of ribosome [GO:0003735] | 8361.640456540914 | 0.348465769162603 | 0.215059566683762 | 0.504148740103516 |
| O43920 | O43920 | NDUS5_HUMAN | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 (Complex I-15 kDa) (CI-15 kDa) (NADH-ubiquinone oxidoreductase 15 kDa subunit) | NDUFS5 | aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776] | mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739] | NADH dehydrogenase (ubiquinone) activity [GO:0008137] | 53151.58586393965 | 0.286408834399873 | 0.215545296448166 | 0.505078432454635 |
| P20933 | P20933 | ASPG_HUMAN | N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) (Aspartylglucosaminidase) (Glycosylasparaginase) (N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase) [Cleaved into: Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain] | AGA | protein deglycosylation [GO:0006517]; proteolysis [GO:0006508] | azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosome [GO:0005764] | asparaginase activity [GO:0004067]; beta-aspartyl-peptidase activity [GO:0008798]; N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity [GO:0003948] | 70170.05858169455 | 0.177996715727231 | 0.215638706093407 | 0.50508842857596 |
| Q13951 | Q13951 | PEBB_HUMAN | Core-binding factor subunit beta (CBF-beta) (Polyomavirus enhancer-binding protein 2 beta subunit) (PEA2-beta) (PEBP2-beta) (SL3-3 enhancer factor 1 subunit beta) (SL3/AKV core-binding factor beta subunit) | CBFB | cell maturation [GO:0048469]; definitive hemopoiesis [GO:0060216]; lymphocyte differentiation [GO:0030098]; myeloid cell differentiation [GO:0030099]; negative regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043371]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043378]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein polyubiquitination [GO:0000209]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366] | core-binding factor complex [GO:0016513]; membrane [GO:0016020]; nucleoplasm [GO:0005654] | sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713] | 19906.73610025575 | 0.180439184709749 | 0.216013491294729 | 0.50569055965494 |
| P35250 | P35250 | RFC2_HUMAN | Replication factor C subunit 2 (Activator 1 40 kDa subunit) (A1 40 kDa subunit) (Activator 1 subunit 2) (Replication factor C 40 kDa subunit) (RF-C 40 kDa subunit) (RFC40) | RFC2 | DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264] | Ctf18 RFC-like complex [GO:0031390]; DNA replication factor C complex [GO:0005663]; Elg1 RFC-like complex [GO:0031391]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rad17 RFC-like complex [GO:0031389] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; enzyme binding [GO:0019899] | 11555.0086127084 | -0.30766355430346 | 0.216074275489695 | 0.50569055965494 |
| Q9BSR8 | Q9BSR8 | YIPF4_HUMAN | Protein YIPF4 (YIP1 family member 4) | YIPF4 | endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle fusion with Golgi apparatus [GO:0048280] | endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] | 14384.61310872685 | -0.501777226304492 | 0.216182886876787 | 0.505735853445034 | |
| P51452 | P51452 | DUS3_HUMAN | Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase VHR) (Vaccinia H1-related phosphatase) (VHR) | DUSP3 | cellular response to epidermal growth factor stimulus [GO:0071364]; dephosphorylation [GO:0016311]; negative regulation of cell migration [GO:0030336]; negative regulation of chemotaxis [GO:0050922]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of JNK cascade [GO:0046329]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell receptor signaling pathway [GO:0050860]; peptidyl-tyrosine dephosphorylation [GO:0035335]; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [GO:1990264]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of mitotic cell cycle [GO:0045931]; regulation of focal adhesion assembly [GO:0051893] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | cytoskeletal protein binding [GO:0008092]; MAP kinase phosphatase activity [GO:0033549]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein kinase binding [GO:0019901]; protein tyrosine kinase binding [GO:1990782]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; receptor tyrosine kinase binding [GO:0030971] | 68917.23199128015 | -0.131768892944859 | 0.216315662425873 | 0.505837615891456 |
| Q9NYJ8 | Q9NYJ8 | TAB2_HUMAN | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2) | TAB2 | defense response to bacterium [GO:0042742]; heart development [GO:0007507]; inflammatory response [GO:0006954]; negative regulation of autophagy [GO:0010507]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein kinase activity [GO:0045860]; response to lipopolysaccharide [GO:0032496] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] | K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; molecular adaptor activity [GO:0060090]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270] | 6234.158363991644 | 0.203492951192346 | 0.216481954228496 | 0.506017637235421 |
| Q99614 | Q99614 | TTC1_HUMAN | Tetratricopeptide repeat protein 1 (TPR repeat protein 1) | TTC1 | protein folding [GO:0006457] | cytosol [GO:0005829]; peroxisomal membrane [GO:0005778] | unfolded protein binding [GO:0051082] | 17896.42767915065 | 0.210065924320659 | 0.216903844773002 | 0.506794715251064 |
| Q15773 | Q15773 | MLF2_HUMAN | Myeloid leukemia factor 2 (Myelodysplasia-myeloid leukemia factor 2) | MLF2 | regulation of DNA-templated transcription [GO:0006355] | cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] | 5328.33982740404 | 0.348969635564661 | 0.217167283050177 | 0.507003678208794 | |
| O95989 | O95989 | NUDT3_HUMAN | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP-1) (EC 3.6.1.52) (Diadenosine hexaphosphate hydrolase) (Ap6A hydrolase) (EC 3.6.1.61) (Endopolyphosphatase) (EC 3.6.1.10) (Nucleoside diphosphate-linked moiety X motif 3) (Nudix motif 3) (m7GpppN-mRNA hydrolase) (EC 3.6.1.62) (m7GpppX diphosphatase) (EC 3.6.1.59) | NUDT3 | adenosine 5'-(hexahydrogen pentaphosphate) catabolic process [GO:1901911]; cell-cell signaling [GO:0007267]; diadenosine hexaphosphate catabolic process [GO:1901909]; diadenosine pentaphosphate catabolic process [GO:1901907]; diadenosine polyphosphate catabolic process [GO:0015961]; diphosphoinositol polyphosphate catabolic process [GO:0071544]; diphosphoinositol polyphosphate metabolic process [GO:0071543]; RNA decapping [GO:0110154] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634] | 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity [GO:0140932]; 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity [GO:0140933]; bis(5'-adenosyl)-hexaphosphatase activity [GO:0034431]; bis(5'-adenosyl)-pentaphosphatase activity [GO:0034432]; diphosphoinositol-polyphosphate diphosphatase activity [GO:0008486]; endopolyphosphatase activity [GO:0000298]; inositol diphosphate pentakisphosphate diphosphatase activity [GO:0052842]; inositol diphosphate tetrakisphosphate diphosphatase activity [GO:0052840]; inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity [GO:0052848]; inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity [GO:0052845]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; zinc ion binding [GO:0008270] | 8921.91907469038 | 0.360661416834965 | 0.217172242677858 | 0.507003678208794 |
| Q86V85 | Q86V85 | GP180_HUMAN | Integral membrane protein GPR180 (Intimal thickness-related receptor) | GPR180 | G protein-coupled receptor signaling pathway [GO:0007186]; response to pheromone [GO:0019236] | membrane [GO:0016020] | 5502.4020803527255 | -0.10886210223273 | 0.217268855602767 | 0.507020319540889 | |
| P20674 | P20674 | COX5A_HUMAN | Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va) | COX5A | cellular respiration [GO:0045333]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123] | mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751] | cytochrome-c oxidase activity [GO:0004129]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872] | 28754.85983831525 | 0.232749254143913 | 0.21768833671673 | 0.507581117628391 |
| Q9P1Y6 | Q9P1Y6 | PHRF1_HUMAN | PHD and RING finger domain-containing protein 1 | PHRF1 | protein ubiquitination [GO:0016567] | membrane [GO:0016020] | metal ion binding [GO:0046872]; RNA polymerase binding [GO:0070063] | 1624.65363680808 | 1.35443389098815 | 0.220318359740175 | 0.513291046993353 |
| P09619 | P09619 | PGFRB_HUMAN | Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b) | PDGFRB | aorta morphogenesis [GO:0035909]; cardiac myofibril assembly [GO:0055003]; cell chemotaxis [GO:0060326]; cell migration involved in coronary angiogenesis [GO:0060981]; cell migration involved in vasculogenesis [GO:0035441]; metanephric glomerular capillary formation [GO:0072277]; metanephric glomerular mesangial cell proliferation involved in metanephros development [GO:0072262]; peptidyl-tyrosine phosphorylation [GO:0018108]; phosphatidylinositol metabolic process [GO:0046488]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; platelet-derived growth factor receptor-beta signaling pathway [GO:0035791]; positive regulation of calcium ion import [GO:0090280]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [GO:0038091]; positive regulation of chemotaxis [GO:0050921]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [GO:0035793]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase C activity [GO:0010863]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; protein autophosphorylation [GO:0046777]; regulation of actin cytoskeleton organization [GO:0032956]; retina vasculature development in camera-type eye [GO:0061298]; signal transduction [GO:0007165]; smooth muscle cell chemotaxis [GO:0071670] | apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] | ATP binding [GO:0005524]; enzyme binding [GO:0019899]; platelet activating factor receptor activity [GO:0004992]; platelet-derived growth factor beta-receptor activity [GO:0005019]; platelet-derived growth factor binding [GO:0048407]; platelet-derived growth factor receptor activity [GO:0005017]; platelet-derived growth factor receptor binding [GO:0005161]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102]; vascular endothelial growth factor binding [GO:0038085] | 4162.51136023256 | -2.14536341344512 | 0.220643160524565 | 0.513836476585361 |
| O15160 | O15160 | RPAC1_HUMAN | DNA-directed RNA polymerases I and III subunit RPAC1 (DNA-directed RNA polymerase I subunit C) (RNA polymerases I and III subunit AC1) (AC40) (DNA-directed RNA polymerases I and III 40 kDa polypeptide) (RPA40) (RPA39) (RPC40) | POLR1C | transcription by RNA polymerase I [GO:0006360] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase I complex [GO:0005736]; RNA polymerase III complex [GO:0005666] | DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; protein dimerization activity [GO:0046983]; RNA polymerase I activity [GO:0001054]; RNA polymerase III activity [GO:0001056] | 5884.42378546102 | 0.364800480188346 | 0.220891522432978 | 0.514203519353021 |
| P01137 | P01137 | TGFB1_HUMAN | Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)] | TGFB1 | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [GO:0002460]; aortic valve morphogenesis [GO:0003180]; ATP biosynthetic process [GO:0006754]; branch elongation involved in mammary gland duct branching [GO:0060751]; bronchiole development [GO:0060435]; canonical Wnt signaling pathway [GO:0060070]; cell morphogenesis [GO:0000902]; cell-cell junction organization [GO:0045216]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucose stimulus [GO:0071333]; cellular response to hypoxia [GO:0071456]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to ionizing radiation [GO:0071479]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to mechanical stimulus [GO:0071260]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to virus [GO:0098586]; chondrocyte differentiation [GO:0002062]; columnar/cuboidal epithelial cell maturation [GO:0002069]; connective tissue replacement involved in inflammatory response wound healing [GO:0002248]; defense response to fungus [GO:0050832]; digestive tract development [GO:0048565]; embryonic liver development [GO:1990402]; endoderm development [GO:0007492]; epithelial cell proliferation [GO:0050673]; epithelial to mesenchymal transition [GO:0001837]; extracellular matrix assembly [GO:0085029]; extrinsic apoptotic signaling pathway [GO:0097191]; face morphogenesis [GO:0060325]; female pregnancy [GO:0007565]; frontal suture morphogenesis [GO:0060364]; gene expression [GO:0010467]; germ cell migration [GO:0008354]; heart development [GO:0007507]; heart valve morphogenesis [GO:0003179]; hematopoietic progenitor cell differentiation [GO:0002244]; hyaluronan catabolic process [GO:0030214]; inner ear development [GO:0048839]; intracellular calcium ion homeostasis [GO:0006874]; Langerhans cell differentiation [GO:0061520]; lens fiber cell differentiation [GO:0070306]; liver regeneration [GO:0097421]; lung alveolus development [GO:0048286]; lymph node development [GO:0048535]; macrophage derived foam cell differentiation [GO:0010742]; mammary gland branching involved in thelarche [GO:0060744]; membrane protein intracellular domain proteolysis [GO:0031293]; muscle cell cellular homeostasis [GO:0046716]; myelination [GO:0042552]; myofibroblast differentiation [GO:0036446]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of extracellular matrix disassembly [GO:0010716]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002859]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of ossification [GO:0030279]; negative regulation of phagocytosis [GO:0050765]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of release of sequestered calcium ion into cytosol [GO:0051280]; negative regulation of skeletal muscle tissue development [GO:0048642]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; neuron apoptotic process [GO:0051402]; Notch signaling pathway [GO:0007219]; odontoblast differentiation [GO:0071895]; odontogenesis of dentin-containing tooth [GO:0042475]; oligodendrocyte development [GO:0014003]; osteoclast differentiation [GO:0030316]; phosphate-containing compound metabolic process [GO:0006796]; phospholipid homeostasis [GO:0055091]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of chemotaxis [GO:0050921]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of exit from mitosis [GO:0031536]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; positive regulation of microglia differentiation [GO:0014008]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of mononuclear cell migration [GO:0071677]; positive regulation of odontogenesis [GO:0042482]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of primary miRNA processing [GO:2000636]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein secretion [GO:0050714]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of receptor signaling pathway via STAT [GO:1904894]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of smooth muscle cell differentiation [GO:0051152]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of vascular permeability [GO:0043117]; positive regulation of vasculature development [GO:1904018]; protein export from nucleus [GO:0006611]; receptor catabolic process [GO:0032801]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of blood vessel remodeling [GO:0060312]; regulation of branching involved in mammary gland duct morphogenesis [GO:0060762]; regulation of cartilage development [GO:0061035]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]; regulation of enamel mineralization [GO:0070173]; regulation of interleukin-23 production [GO:0032667]; regulation of protein import into nucleus [GO:0042306]; regulation of sodium ion transport [GO:0002028]; regulation of striated muscle tissue development [GO:0016202]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; regulatory T cell differentiation [GO:0045066]; response to cholesterol [GO:0070723]; response to estradiol [GO:0032355]; response to immobilization stress [GO:0035902]; response to laminar fluid shear stress [GO:0034616]; response to progesterone [GO:0032570]; response to salt [GO:1902074]; response to vitamin D [GO:0033280]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; retina vasculature development in camera-type eye [GO:0061298]; salivary gland morphogenesis [GO:0007435]; sprouting angiogenesis [GO:0002040]; stem cell proliferation [GO:0072089]; surfactant homeostasis [GO:0043129]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]; tolerance induction to self antigen [GO:0002513]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]; vasculogenesis [GO:0001570]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] | axon [GO:0030424]; blood microparticle [GO:0072562]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093] | antigen binding [GO:0003823]; cytokine activity [GO:0005125]; deubiquitinase activator activity [GO:0035800]; enzyme binding [GO:0019899]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; protein serine/threonine kinase activator activity [GO:0043539]; protein-containing complex binding [GO:0044877]; type I transforming growth factor beta receptor binding [GO:0034713]; type II transforming growth factor beta receptor binding [GO:0005114]; type III transforming growth factor beta receptor binding [GO:0034714] | 8330.84134865798 | 0.267763944042689 | 0.221837994025895 | 0.515982789060231 |
| O75379 | O75379 | VAMP4_HUMAN | Vesicle-associated membrane protein 4 (VAMP-4) | VAMP4 | endocytic recycling [GO:0032456]; Golgi ribbon formation [GO:0090161]; regulation of synaptic vesicle endocytosis [GO:1900242]; SNARE complex assembly [GO:0035493]; synaptic vesicle to endosome fusion [GO:0016189] | cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; SNARE complex [GO:0031201]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133] | 17508.07464429965 | -0.346176813752341 | 0.221974628174364 | 0.51608873337544 | |
| Q9BUB7 | Q9BUB7 | TMM70_HUMAN | Transmembrane protein 70, mitochondrial | TMEM70 | mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]; protein complex oligomerization [GO:0051259]; protein homooligomerization [GO:0051260] | mitochondrial crista [GO:0030061]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] | mitochondrial proton-transporting ATP synthase complex binding [GO:0140260] | 5430.810103205165 | 0.604822344173067 | 0.22210139607797 | 0.516171661270623 |
| Q9BZZ5 | Q9BZZ5 | API5_HUMAN | Apoptosis inhibitor 5 (API-5) (Antiapoptosis clone 11 protein) (AAC-11) (Cell migration-inducing gene 8 protein) (Fibroblast growth factor 2-interacting factor) (FIF) (Protein XAGL) | API5 | fibroblast apoptotic process [GO:0044346]; localization [GO:0051179]; negative regulation of apoptotic process [GO:0043066]; negative regulation of fibroblast apoptotic process [GO:2000270] | cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] | fibroblast growth factor binding [GO:0017134]; mRNA binding [GO:0003729]; RNA binding [GO:0003723] | 27850.981674936498 | -0.0958834901821177 | 0.222220577826714 | 0.516207637246169 |
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| Q15149 | |||||||||
| Q99715 | |||||||||
| P02452 | |||||||||
| P02751 | |||||||||
| P98160 | |||||||||
| P08123 | |||||||||
| P02461 | |||||||||
| P07996 | |||||||||
| Q8WWI1 | |||||||||
| P05997 | |||||||||
| P20908 | |||||||||
| Q8WUJ3 | |||||||||
| P21333 | |||||||||
| O75369 | |||||||||
| Q15063 | |||||||||
| P02786 | |||||||||
| Q12884 | |||||||||
| P12814 | |||||||||
| Q9UDY2 | |||||||||
| Q14195 | |||||||||
| Q02952 | |||||||||
| Q9NZM1 | |||||||||
| P35579 | |||||||||
| P35354 | |||||||||
| P47895 | |||||||||
| Q09666 | |||||||||
| P11717 | |||||||||
| Q14112 | |||||||||
| Q13620 | |||||||||
| P43490 | |||||||||
| Q3SY69 | |||||||||
| P17812 | |||||||||
| P21980 | |||||||||
| Q16647 | |||||||||
| P01024 | |||||||||
| Q5SW79 | |||||||||
| P06396 | |||||||||
| P12111 | |||||||||
| P35221 | |||||||||
| P12429 | |||||||||
| P78559 | |||||||||
| Q76M96 | |||||||||
| Q16881 | |||||||||
| P07093 | |||||||||
| P27487 | |||||||||
| P15144 | |||||||||
| Q9H5V8 | |||||||||
| P08729 | |||||||||
| Q04828 | |||||||||
| O94925 | |||||||||
| P08473 | |||||||||
| Q8IVL5 | |||||||||
| P35442 | |||||||||
| O60716 | |||||||||
| P08253 | |||||||||
| Q16822 | |||||||||
| Q9UJ72 | |||||||||
| Q9Y617 | |||||||||
| Q8WX93 | |||||||||
| Q32MZ4 | |||||||||
| Q6P179 | |||||||||
| P48681 | |||||||||
| O95340 | |||||||||
| P21580 | |||||||||
| Q00341 | |||||||||
| P49748 | |||||||||
| O43854 | |||||||||
| P07942 | |||||||||
| Q96KC8 | |||||||||
| Q96PD2 | |||||||||
| Q13418 | |||||||||
| Q7Z7G0 | |||||||||
| Q04446 | |||||||||
| P19022 | |||||||||
| O00469 | |||||||||
| Q8WUF5 | |||||||||
| Q14767 | |||||||||
| Q13308 | |||||||||
| P46940 | |||||||||
| Q9NZ08 | |||||||||
| O60488 | |||||||||
| P35222 | |||||||||
| Q9H4M9 | |||||||||
| Q9NZU5 | |||||||||
| Q15113 | |||||||||
| O94808 | |||||||||
| Q9UI42 | |||||||||
| Q15417 | |||||||||
| Q15582 | |||||||||
| P35908 | |||||||||
| P00750 | |||||||||
| Q9UHD8 | |||||||||
| P11047 | |||||||||
| Q8N6G6 | |||||||||
| Q05682 | |||||||||
| P17342 | |||||||||
| Q16363 | |||||||||
| Q9NR12 | |||||||||
| P05362 | |||||||||
| P00966 | |||||||||
| P05120 | |||||||||
| P15121 | |||||||||
| P04179 | |||||||||
| Q15785 | |||||||||
| O60271 | |||||||||
| Q9Y6N5 | |||||||||
| Q9P0V9 | |||||||||
| Q8IVF2 | |||||||||
| P01584 | |||||||||
| Q96AQ6 | |||||||||
| P54289 | |||||||||
| P13667 | |||||||||
| Q96HE7 | |||||||||
| P21810 | |||||||||
| Q16790 | |||||||||
| P23396 | |||||||||
| P01130 | |||||||||
| P51812 | |||||||||
| O95490 | |||||||||
| Q16222 | |||||||||
| Q7Z4N8 | |||||||||
| P08133 | |||||||||
| Q08431 | |||||||||
| P23142 | |||||||||
| Q01581 | |||||||||
| P10915 | |||||||||
| O75976 | |||||||||
| P23219 | |||||||||
| Q8IXK2 | |||||||||
| Q07954 | |||||||||
| P50225 | |||||||||
| P11413 | |||||||||
| Q5SSJ5 | |||||||||
| Q6PCE3 | |||||||||
| P05091 | |||||||||
| P49419 | |||||||||
| P41252 | |||||||||
| P50281 | |||||||||
| Q13618 | |||||||||
| Q00653 | |||||||||
| Q9BZG1 | |||||||||
| P11142 | |||||||||
| P63010 | |||||||||
| Q9UBG0 | |||||||||
| Q5GLZ8 | |||||||||
| P21266 | |||||||||
| Q9BS40 | |||||||||
| P35232 | |||||||||
| Q86VP6 | |||||||||
| P09601 | |||||||||
| Q8N8S7 | |||||||||
| Q16851 | |||||||||
| P28845 | |||||||||
| P26640 | |||||||||
| Q92626 | |||||||||
| P07686 | |||||||||
| P01583 | |||||||||
| Q96HH9 | |||||||||
| P48506 | |||||||||
| P47712 | |||||||||
| Q14314 | |||||||||
| Q53FA7 | |||||||||
| Q9H425 | |||||||||
| Q14204 | |||||||||
| P01033 | |||||||||
| Q92616 | |||||||||
| Q16666 | |||||||||
| Q99623 | |||||||||
| P23381 | |||||||||
| Q8N6Y2 | |||||||||
| P98155 | |||||||||
| P46977 | |||||||||
| Q86SQ0 | |||||||||
| Q70E73 | |||||||||
| Q6VY07 | |||||||||
| P41250 | |||||||||
| P56945 | |||||||||
| P29279 | |||||||||
| Q96C19 | |||||||||
| Q9UPN3 | |||||||||
| P26022 | |||||||||
| P00492 | |||||||||
| Q9BXS4 | |||||||||
| P50452 | |||||||||
| P05783 | |||||||||
| Q14980 | |||||||||
| Q9UBX5 | |||||||||
| O75094 | |||||||||
| Q06323 | |||||||||
| O14672 | |||||||||
| O00339 | |||||||||
| P52209 | |||||||||
| Q00325 | |||||||||
| P30044 | |||||||||
| P30740 | |||||||||
| P46734 | |||||||||
| P48307 | |||||||||
| P08648 | |||||||||
| O43175 | |||||||||
| O00116 |
