Selected Cell
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Value:
stat_data__min_2_Peptides
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| P82979 | P82979 | SARNP_HUMAN | SAP domain-containing ribonucleoprotein (Cytokine-induced protein of 29 kDa) (Nuclear protein Hcc-1) (Proliferation-associated cytokine-inducible protein CIP29) | SARNP | mRNA export from nucleus [GO:0006406]; negative regulation of transcription by RNA polymerase II [GO:0000122]; poly(A)+ mRNA export from nucleus [GO:0016973]; regulation of translation [GO:0006417] | cytoplasmic ribonucleoprotein granule [GO:0036464]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription export complex [GO:0000346] | chromatin binding [GO:0003682]; DNA binding [GO:0003677]; RNA binding [GO:0003723] | 143328.494855792 | 0.25224086199691 | 0.101104652424696 | 0.291382991169038 |
| Q8N6N3 | Q8N6N3 | CA052_HUMAN | UPF0690 protein C1orf52 (BCL10-associated gene protein) | C1orf52 | nucleoplasm [GO:0005654] | RNA binding [GO:0003723] | 3214.838808530175 | 1.1654559817662 | 0.101191074124309 | 0.291483795621929 | |
| Q9NWS0 | Q9NWS0 | PIHD1_HUMAN | PIH1 domain-containing protein 1 (Nucleolar protein 17 homolog) | PIH1D1 | box C/D snoRNP assembly [GO:0000492]; chromatin remodeling [GO:0006338]; epithelial cell differentiation [GO:0030855]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001268]; positive regulation of glucose mediated signaling pathway [GO:1902661]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; protein stabilization [GO:0050821]; rRNA processing [GO:0006364]; snoRNA localization [GO:0048254]; TORC1 complex assembly [GO:1905669] | cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]; pre-snoRNP complex [GO:0070761]; R2TP complex [GO:0097255]; ribonucleoprotein complex [GO:1990904]; RPAP3/R2TP/prefoldin-like complex [GO:1990062] | ATPase binding [GO:0051117]; histone binding [GO:0042393]; histone reader activity [GO:0140566]; phosphoprotein binding [GO:0051219]; protein kinase binding [GO:0019901] | 7352.8868973566805 | 0.89941596568674 | 0.101722594755664 | 0.292865966405281 |
| Q96S97 | Q96S97 | MYADM_HUMAN | Myeloid-associated differentiation marker (Protein SB135) | MYADM | establishment of endothelial barrier [GO:0061028]; membrane raft organization [GO:0031579]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of gene expression [GO:0010629]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of protein kinase C signaling [GO:0090038]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of cell migration [GO:0030335]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein localization to plasma membrane raft [GO:0044860] | cell-cell junction [GO:0005911]; cortical actin cytoskeleton [GO:0030864]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; ruffle [GO:0001726] | 15534.0401481275 | -0.528326554331169 | 0.102029439421422 | 0.293451169422221 | |
| Q5K4L6 | Q5K4L6 | S27A3_HUMAN | Long-chain fatty acid transport protein 3 (FATP-3) (Fatty acid transport protein 3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 3) (Very long-chain acyl-CoA synthetase homolog 3) (VLCS-3) (EC 6.2.1.-) | SLC27A3 | fatty acid transport [GO:0015908]; long-chain fatty acid metabolic process [GO:0001676] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] | arachidonate-CoA ligase activity [GO:0047676]; ATP binding [GO:0005524]; long-chain fatty acid transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; very long-chain fatty acid-CoA ligase activity [GO:0031957] | 4902.02969054677 | -0.229030840304 | 0.102235296823751 | 0.293894059768327 |
| Q6ZNB6 | Q6ZNB6 | NFXL1_HUMAN | NF-X1-type zinc finger protein NFXL1 (Ovarian zinc finger protein) (hOZFP) | NFXL1 | regulation of DNA-templated transcription [GO:0006355] | chromatin [GO:0000785]; membrane [GO:0016020]; nucleus [GO:0005634] | DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270] | 9496.821816633905 | -0.328265592638341 | 0.102484923993127 | 0.294462261331165 |
| P63244 | P63244 | RACK1_HUMAN | Small ribosomal subunit protein RACK1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed) (Receptor of activated protein C kinase 1, N-terminally processed)] | RACK1 | activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; cell cycle [GO:0007049]; cellular response to glucose stimulus [GO:0071333]; cellular response to growth factor stimulus [GO:0071363]; cytoplasmic translation [GO:0002181]; gastrulation [GO:0007369]; negative regulation of cell growth [GO:0030308]; negative regulation of endoplasmic reticulum unfolded protein response [GO:1900102]; negative regulation of gene expression [GO:0010629]; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:1903751]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of phagocytosis [GO:0050765]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of protein binding [GO:0032091]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of translation [GO:0017148]; negative regulation of Wnt signaling pathway [GO:0030178]; pigmentation [GO:0043473]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of gastrulation [GO:2000543]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998]; positive regulation of GTPase activity [GO:0043547]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein-containing complex assembly [GO:0031334]; protein ubiquitination [GO:0016567]; regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106070]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of establishment of cell polarity [GO:2000114]; regulation of protein localization [GO:0032880]; rescue of stalled ribosome [GO:0072344]; rhythmic process [GO:0048511] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; IRE1-RACK1-PP2A complex [GO:1990630]; midbody [GO:0030496]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]; small ribosomal subunit [GO:0015935] | BH3 domain binding [GO:0051434]; cadherin binding [GO:0045296]; cyclin binding [GO:0030332]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; ion channel inhibitor activity [GO:0008200]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; protein kinase C binding [GO:0005080]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase inhibitor activity [GO:0030292]; receptor tyrosine kinase binding [GO:0030971]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; SH2 domain binding [GO:0042169]; signaling adaptor activity [GO:0035591]; signaling receptor binding [GO:0005102]; translation regulator activity [GO:0045182] | 339197.715729111 | 0.121765096364262 | 0.102644810203762 | 0.294622844282936 |
| Q12983 | Q12983 | BNIP3_HUMAN | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 | BNIP3 | autophagic cell death [GO:0048102]; autophagy of mitochondrion [GO:0000422]; brown fat cell differentiation [GO:0050873]; cardiac muscle cell apoptotic process [GO:0010659]; cellular response to cobalt ion [GO:0071279]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to mechanical stimulus [GO:0071260]; cerebral cortex development [GO:0021987]; defense response to virus [GO:0051607]; granzyme-mediated programmed cell death signaling pathway [GO:0140507]; intrinsic apoptotic signaling pathway in response to hypoxia [GO:1990144]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial outer membrane permeabilization [GO:0097345]; mitochondrial protein catabolic process [GO:0035694]; negative regulation of apoptotic process [GO:0043066]; negative regulation of membrane potential [GO:0045837]; negative regulation of mitochondrial fusion [GO:0010637]; negative regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902109]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of programmed cell death [GO:0043069]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; neuron apoptotic process [GO:0051402]; oligodendrocyte differentiation [GO:0048709]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of autophagy of mitochondrion [GO:1903599]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of macroautophagy [GO:0016239]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of programmed cell death [GO:0043068]; positive regulation of protein-containing complex disassembly [GO:0043243]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; reactive oxygen species metabolic process [GO:0072593]; regulation of aerobic respiration [GO:1903715]; regulation of mitochondrial membrane permeability [GO:0046902]; response to axon injury [GO:0048678]; response to bacterium [GO:0009617]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to oxygen-glucose deprivation [GO:0090649] | cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] | GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] | 33700.77605078545 | 0.313328995276197 | 0.102739540007125 | 0.294745434774872 |
| P35270 | P35270 | SPRE_HUMAN | Sepiapterin reductase (SPR) (EC 1.1.1.153) | SPR | nitric oxide biosynthetic process [GO:0006809]; tetrahydrobiopterin biosynthetic process [GO:0006729] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654] | aldo-keto reductase (NADP) activity [GO:0004033]; NADP binding [GO:0050661]; sepiapterin reductase activity [GO:0004757] | 10647.5981150294 | -0.354825852974295 | 0.102798493192958 | 0.294765314995597 |
| Q9BQK8 | Q9BQK8 | LPIN3_HUMAN | Phosphatidate phosphatase LPIN3 (EC 3.1.3.4) (Lipin-3) (Lipin-3-like) | LPIN3 | cellular response to insulin stimulus [GO:0032869]; fatty acid catabolic process [GO:0009062]; positive regulation of transcription by RNA polymerase II [GO:0045944]; triglyceride biosynthetic process [GO:0019432] | endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] | phosphatidate phosphatase activity [GO:0008195]; transcription coactivator activity [GO:0003713] | 4546.10081113199 | -0.873047727156153 | 0.103849618668528 | 0.297478230220365 |
| P08865 | P08865 | RSSA_HUMAN | Small ribosomal subunit protein uS2 (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (40S ribosomal protein SA) (67 kDa laminin receptor) (67LR) (Colon carcinoma laminin-binding protein) (Laminin receptor 1) (LamR) (Laminin-binding protein precursor p40) (LBP/p40) (Multidrug resistance-associated protein MGr1-Ag) (NEM/1CHD4) | RPSA | cytoplasmic translation [GO:0002181]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] | 90S preribosome [GO:0030686]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | laminin binding [GO:0043236]; laminin receptor activity [GO:0005055]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; virus receptor activity [GO:0001618] | 165752.823818756 | 0.194193670240027 | 0.104025383490907 | 0.297530450711499 |
| Q12888 | Q12888 | TP53B_HUMAN | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | TP53BP1 | cellular response to X-ray [GO:0071481]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; double-strand break repair via nonhomologous end joining [GO:0006303]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of isotype switching [GO:0045830]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homooligomerization [GO:0051260]; protein localization to site of double-strand break [GO:1990166] | chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; DNA repair complex [GO:1990391]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]; site of double-strand break [GO:0035861] | damaged DNA binding [GO:0003684]; histone binding [GO:0042393]; histone reader activity [GO:0140566]; methylated histone binding [GO:0035064]; p53 binding [GO:0002039]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; telomeric DNA binding [GO:0042162]; transcription coregulator activity [GO:0003712]; ubiquitin modification-dependent histone binding [GO:0061649] | 12461.555853750051 | -0.162653047007032 | 0.103947537777768 | 0.297530450711499 |
| Q9C005 | Q9C005 | DPY30_HUMAN | Protein dpy-30 homolog (Dpy-30-like protein) (Dpy-30L) | DPY30 | endosomal transport [GO:0016197]; transcription initiation-coupled chromatin remodeling [GO:0045815] | Golgi apparatus [GO:0005794]; histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188]; trans-Golgi network [GO:0005802] | identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] | 5949.38666471731 | -0.561504921049336 | 0.104162823546613 | 0.297773238251821 |
| Q96GS4 | Q96GS4 | BORC6_HUMAN | BLOC-1-related complex subunit 6 (Lysosome-dispersing protein) (Lyspersin) | BORCS6 | lysosome localization [GO:0032418]; organelle transport along microtubule [GO:0072384]; regulation of endosome size [GO:0051036]; regulation of lysosome size [GO:0062196] | BORC complex [GO:0099078]; cytoplasmic side of lysosomal membrane [GO:0098574] | identical protein binding [GO:0042802] | 10135.592695160805 | -0.33720056958459 | 0.104628874624591 | 0.29895471690516 |
| O15372 | O15372 | EIF3H_HUMAN | Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p40 subunit) | EIF3H | formation of cytoplasmic translation initiation complex [GO:0001732]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413] | cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; extracellular exosome [GO:0070062]; membrane [GO:0016020] | metal-dependent deubiquitinase activity [GO:0140492]; metallopeptidase activity [GO:0008237]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] | 40972.483127750704 | 0.13657006885959 | 0.104784130803691 | 0.299247421942395 |
| O15400 | O15400 | STX7_HUMAN | Syntaxin-7 | STX7 | intracellular protein transport [GO:0006886]; organelle assembly [GO:0070925]; organelle localization [GO:0051640]; positive regulation of receptor localization to synapse [GO:1902685]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; regulation of protein localization to plasma membrane [GO:1903076]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] | azurophil granule [GO:0042582]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endomembrane system [GO:0012505]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; immunological synapse [GO:0001772]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; tertiary granule [GO:0070820]; vesicle [GO:0031982] | chloride channel inhibitor activity [GO:0019869]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905] | 116409.775420677 | -0.22242857953503 | 0.104946371252206 | 0.299559768017632 |
| Q0JRZ9 | Q0JRZ9 | FCHO2_HUMAN | F-BAR domain only protein 2 | FCHO2 | clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; membrane invagination [GO:0010324]; protein localization to plasma membrane [GO:0072659]; synaptic vesicle endocytosis [GO:0048488] | clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; presynaptic endocytic zone membrane [GO:0098835] | identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786] | 6435.64983171737 | -0.186293312814545 | 0.105093098935842 | 0.299827542079799 |
| Q16658 | Q16658 | FSCN1_HUMAN | Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55) | FSCN1 | actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; cell migration [GO:0016477]; cell motility [GO:0048870]; cell-cell junction assembly [GO:0007043]; establishment of apical/basal cell polarity [GO:0035089]; establishment or maintenance of cell polarity [GO:0007163]; microspike assembly [GO:0030035]; parallel actin filament bundle assembly [GO:0030046]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of podosome assembly [GO:0071803]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of microvillus assembly [GO:0032534] | actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; cell projection membrane [GO:0031253]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; microspike [GO:0044393]; microvillus [GO:0005902]; podosome [GO:0002102]; ruffle [GO:0001726]; stress fiber [GO:0001725] | actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723] | 152587.998045497 | -0.190448287221754 | 0.105383409093107 | 0.300353317867979 |
| P23458 | P23458 | JAK1_HUMAN | Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1) | JAK1 | cell differentiation [GO:0030154]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; interleukin-11-mediated signaling pathway [GO:0038154]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; interleukin-4-mediated signaling pathway [GO:0035771]; interleukin-6-mediated signaling pathway [GO:0070102]; interleukin-9-mediated signaling pathway [GO:0038113]; intracellular signal transduction [GO:0035556]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of sprouting angiogenesis [GO:1903672]; protein localization to cell-cell junction [GO:0150105]; protein phosphorylation [GO:0006468]; receptor signaling pathway via JAK-STAT [GO:0007259]; response to antibiotic [GO:0046677]; T-helper 17 cell lineage commitment [GO:0072540]; type I interferon-mediated signaling pathway [GO:0060337]; type II interferon-mediated signaling pathway [GO:0060333]; type III interferon-mediated signaling pathway [GO:0038196] | cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome [GO:0005768]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | ATP binding [GO:0005524]; CCR5 chemokine receptor binding [GO:0031730]; growth hormone receptor binding [GO:0005131]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; ubiquitin protein ligase binding [GO:0031625] | 7206.4658351524795 | -0.307216655727011 | 0.105376961236714 | 0.300353317867979 |
| Q15847 | Q15847 | ADIRF_HUMAN | Adipogenesis regulatory factor (Adipogenesis factor rich in obesity) (Adipose most abundant gene transcript 2 protein) (Adipose-specific protein 2) (apM-2) | ADIRF | cell differentiation [GO:0030154]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of transcription by RNA polymerase II [GO:0045944] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | 15544.026023980401 | -0.657446979645653 | 0.105485565365721 | 0.300401114209617 | |
| Q99653 | Q99653 | CHP1_HUMAN | Calcineurin B homologous protein 1 (Calcineurin B-like protein) (Calcium-binding protein CHP) (Calcium-binding protein p22) (EF-hand calcium-binding domain-containing protein p22) | CHP1 | cellular response to acidic pH [GO:0071468]; cytoplasmic microtubule organization [GO:0031122]; membrane docking [GO:0022406]; membrane fusion [GO:0061025]; membrane organization [GO:0061024]; microtubule bundle formation [GO:0001578]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphatase activity [GO:0010923]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of phospholipid biosynthetic process [GO:0071073]; positive regulation of protein glycosylation [GO:0060050]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of protein transport [GO:0051222]; positive regulation of sodium:proton antiporter activity [GO:0032417]; potassium ion transport [GO:0006813]; protein export from nucleus [GO:0006611]; protein stabilization [GO:0050821]; regulation of intracellular pH [GO:0051453]; small GTPase-mediated signal transduction [GO:0007264] | cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; membrane raft [GO:0045121]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]; transporter complex [GO:1990351] | calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; kinase binding [GO:0019900]; microtubule binding [GO:0008017]; potassium channel regulator activity [GO:0015459]; protein kinase inhibitor activity [GO:0004860]; sodium:proton antiporter activity [GO:0015385] | 26772.294478441698 | 0.394266112016852 | 0.105541155196966 | 0.300401114209617 |
| Q7Z460 | Q7Z460 | CLAP1_HUMAN | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) | CLASP1 | astral microtubule organization [GO:0030953]; cell division [GO:0051301]; establishment of epithelial cell polarity [GO:0090162]; establishment of mitotic spindle localization [GO:0040001]; establishment of spindle orientation [GO:0051294]; establishment or maintenance of cell polarity [GO:0007163]; exit from mitosis [GO:0010458]; Golgi organization [GO:0007030]; microtubule anchoring [GO:0034453]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; microtubule nucleation [GO:0007020]; microtubule organizing center organization [GO:0031023]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of microtubule polymerization or depolymerization [GO:0031111]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of wound healing, spreading of epidermal cells [GO:1903690]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of exocytosis [GO:0045921]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of microtubule polymerization [GO:0031116]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of focal adhesion assembly [GO:0051893]; regulation of gastrulation [GO:0010470]; regulation of microtubule cytoskeleton organization [GO:0070507]; vesicle targeting [GO:0006903] | basal cortex [GO:0045180]; cell cortex [GO:0005938]; centrosomal corona [GO:0031592]; centrosome [GO:0005813]; cortical microtubule cytoskeleton [GO:0030981]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; microtubule plus-end [GO:0035371]; mitotic spindle [GO:0072686]; spindle microtubule [GO:0005876] | dystroglycan binding [GO:0002162]; kinetochore binding [GO:0043515]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010] | 7897.598229518795 | -0.249798133958357 | 0.105665270141152 | 0.300401114209617 |
| A1X283 | A1X283 | SPD2B_HUMAN | SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains) | SH3PXD2B | adipose tissue development [GO:0060612]; bone development [GO:0060348]; cell differentiation [GO:0030154]; extracellular matrix disassembly [GO:0022617]; eye development [GO:0001654]; heart development [GO:0007507]; podosome assembly [GO:0071800]; protein localization to membrane [GO:0072657]; skeletal system development [GO:0001501]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801] | anchoring junction [GO:0070161]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; podosome [GO:0002102] | phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-5-phosphate binding [GO:0010314]; SH2 domain binding [GO:0042169]; superoxide-generating NADPH oxidase activator activity [GO:0016176] | 13993.43338007865 | 0.242278512184708 | 0.105614740182663 | 0.300401114209617 |
| Q9H9S5 | Q9H9S5 | FKRP_HUMAN | Ribitol 5-phosphate transferase FKRP (EC 2.7.8.-) (Fukutin-related protein) (Ribitol-5-phosphate transferase) | FKRP | adult walking behavior [GO:0007628]; basement membrane organization [GO:0071711]; bone mineralization [GO:0030282]; brain development [GO:0007420]; camera-type eye development [GO:0043010]; connective tissue development [GO:0061448]; connective tissue replacement [GO:0097709]; creatine metabolic process [GO:0006600]; diaphragm development [GO:0060539]; filtration diaphragm assembly [GO:0036058]; glial cell differentiation [GO:0010001]; glycolytic process [GO:0006096]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; inflammatory response [GO:0006954]; lipid metabolic process [GO:0006629]; localization of cell [GO:0051674]; maintenance of protein localization in endoplasmic reticulum [GO:0035437]; muscle contraction [GO:0006936]; neuromuscular process [GO:0050905]; neuron migration [GO:0001764]; oxygen metabolic process [GO:0072592]; pentitol metabolic process [GO:0019519]; pentose metabolic process [GO:0019321]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; protein import [GO:0017038]; protein O-linked mannosylation [GO:0035269]; protein processing [GO:0016485]; protein tetramerization [GO:0051262]; reelin-mediated signaling pathway [GO:0038026]; reproductive process [GO:0022414]; respiratory system process [GO:0003016]; response to activity [GO:0014823]; response to alcohol [GO:0097305]; response to glucocorticoid [GO:0051384]; response to xenobiotic stimulus [GO:0009410]; skeletal muscle fiber differentiation [GO:0098528]; skeletal muscle tissue regeneration [GO:0043403] | cytosol [GO:0005829]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; rough endoplasmic reticulum [GO:0005791]; sarcolemma [GO:0042383]; skeletal muscle myofibril [GO:0098723] | dystroglycan binding [GO:0002162]; identical protein binding [GO:0042802]; laminin binding [GO:0043236]; metal ion binding [GO:0046872]; phosphotransferase activity, for other substituted phosphate groups [GO:0016780] | 7311.18539550476 | 0.433482962128944 | 0.106103985045963 | 0.301497080877847 |
| O60343 | O60343 | TBCD4_HUMAN | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) | TBC1D4 | cellular response to insulin stimulus [GO:0032869]; negative regulation of vesicle fusion [GO:0031339]; vesicle-mediated transport [GO:0016192] | cytosol [GO:0005829]; vesicle [GO:0031982] | GTPase activator activity [GO:0005096] | 3098.368285786385 | -0.490071168381945 | 0.106188625919577 | 0.301586343087882 |
| P07311 | P07311 | ACYP1_HUMAN | Acylphosphatase-1 (EC 3.6.1.7) (Acylphosphatase, erythrocyte isozyme) (Acylphosphatase, organ-common type isozyme) (Acylphosphate phosphohydrolase 1) | ACYP1 | phosphate-containing compound metabolic process [GO:0006796] | acylphosphatase activity [GO:0003998] | 14889.9089121412 | -0.870999222415429 | 0.106906374736704 | 0.303472705039161 | |
| Q9HD15 | Q9HD15 | SRA1_HUMAN | Steroid receptor RNA activator 1 (Steroid receptor RNA activator protein) (SRAP) | SRA1 | apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cellular response to estrogen stimulus [GO:0071391]; negative regulation of myoblast differentiation [GO:0045662]; regulation of apoptotic process [GO:0042981]; regulation of mitotic cell cycle [GO:0007346] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; SCAR complex [GO:0031209] | nuclear receptor coactivator activity [GO:0030374]; steroid receptor RNA activator RNA binding [GO:0002153]; transcription coactivator activity [GO:0003713] | 27603.655878778452 | 0.248685959110017 | 0.107096765774716 | 0.303708846286055 |
| Q96KR6 | Q96KR6 | F210B_HUMAN | Protein FAM210B, mitochondrial | FAM210B | cellular response to estradiol stimulus [GO:0071392]; erythrocyte maturation [GO:0043249]; positive regulation of erythrocyte differentiation [GO:0045648] | membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] | 5846.07389629383 | -0.538506268509978 | 0.107512554151626 | 0.304735433628371 | |
| Q9BRA2 | Q9BRA2 | TXD17_HUMAN | Thioredoxin domain-containing protein 17 (14 kDa thioredoxin-related protein) (TRP14) (Protein 42-9-9) (Thioredoxin-like protein 5) | TXNDC17 | tumor necrosis factor-mediated signaling pathway [GO:0033209] | cytosol [GO:0005829]; extracellular exosome [GO:0070062] | peroxidase activity [GO:0004601]; protein-disulfide reductase (NAD(P)) activity [GO:0047134] | 39979.53936086355 | 0.298046035467657 | 0.108257248275238 | 0.306539514606446 |
| P82673 | P82673 | RT35_HUMAN | Small ribosomal subunit protein mS35 (28S ribosomal protein S28, mitochondrial) (MRP-S28) (S28mt) (28S ribosomal protein S35, mitochondrial) (MRP-S35) (S35mt) | MRPS35 | mitochondrial translation [GO:0032543] | mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 3310.48523091167 | 0.230826035654294 | 0.108415181550379 | 0.306680189048651 |
| Q7Z406 | Q7Z406 | MYH14_HUMAN | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | MYH14 | actin filament-based movement [GO:0030048]; actomyosin structure organization [GO:0031032]; mitochondrion organization [GO:0007005]; mitotic cytokinesis [GO:0000281]; neuronal action potential [GO:0019228]; regulation of cell shape [GO:0008360]; sensory perception of sound [GO:0007605]; skeletal muscle contraction [GO:0003009]; skeletal muscle tissue development [GO:0007519]; vocalization behavior [GO:0071625] | actomyosin [GO:0042641]; brush border [GO:0005903]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; growth cone [GO:0030426]; membrane [GO:0016020]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; myosin II filament [GO:0097513]; stress fiber [GO:0001725] | actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146] | 188138.62711500202 | -0.504379824703597 | 0.108519348187294 | 0.306821670074454 |
| P28290 | P28290 | ITPI2_HUMAN | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | ITPRID2 | cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] | actin filament binding [GO:0051015]; signaling receptor binding [GO:0005102] | 6101.586358943365 | -0.239596139371729 | 0.109164376462029 | 0.308184034396541 | |
| Q8IY26 | Q8IY26 | PLPP6_HUMAN | Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (EC 3.1.3.-) (EC 3.6.1.-) (EC 3.6.1.68) (Lipid phosphatase-related protein-B) (LPRP-B) (PA-PSP) (Phosphatidic acid phosphatase type 2 domain-containing protein 2) (PPAP2 domain-containing protein 2) (Phospholipid phosphatase 6) (Presqualene diphosphate phosphatase) (Type 1 polyisoprenoid diphosphate phosphatase) | PLPP6 | cholesterol biosynthetic process [GO:0006695]; farnesyl diphosphate catabolic process [GO:0045339]; geranyl diphosphate metabolic process [GO:0033383]; geranylgeranyl diphosphate catabolic process [GO:1902247]; innate immune response [GO:0045087]; isoprenoid metabolic process [GO:0006720]; phospholipid dephosphorylation [GO:0046839]; positive regulation of neutrophil activation [GO:1902565]; protein prenylation [GO:0018342] | endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] | hydrolase activity [GO:0016787]; isoprenoid diphosphate phosphatase activity [GO:0106405]; lipid phosphatase activity [GO:0042577]; lyase activity [GO:0016829]; lysophosphatidic acid phosphatase activity [GO:0052642]; phosphatidate phosphatase activity [GO:0008195]; sphingosine-1-phosphate phosphatase activity [GO:0042392] | 8830.241985611381 | -0.179051359643324 | 0.109162514534629 | 0.308184034396541 |
| Q9Y5K5 | Q9Y5K5 | UCHL5_HUMAN | Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5) | UCHL5 | chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; forebrain morphogenesis [GO:0048853]; lateral ventricle development [GO:0021670]; midbrain development [GO:0030901]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; protein deubiquitination [GO:0016579]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; regulation of proteasomal protein catabolic process [GO:0061136]; telomere maintenance [GO:0000723]; ubiquitin-dependent protein catabolic process [GO:0006511] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; Ino80 complex [GO:0031011]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | cysteine-type deubiquitinase activity [GO:0004843]; endopeptidase inhibitor activity [GO:0004866]; proteasome binding [GO:0070628]; RNA binding [GO:0003723] | 15342.26596987195 | 0.214634692497877 | 0.109433903962209 | 0.308791085582608 |
| P09669 | P09669 | COX6C_HUMAN | Cytochrome c oxidase subunit 6C (Cytochrome c oxidase polypeptide VIc) | COX6C | cellular respiration [GO:0045333]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123] | mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739] | 4923.50287149553 | -2.50830045212407 | 0.110351527906957 | 0.310165658620336 | |
| Q92604 | Q92604 | LGAT1_HUMAN | Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (2-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.62) (Acyl-CoA:monoacylglycerol acyltransferase LPGAT1) (EC 2.3.1.22) (Lysophospholipid acyltransferase 7) (LPLAT7) (EC 2.3.1.-) (Stearoyl-CoA:1-lyso-2-acyl-PE acyltransferase) | LPGAT1 | phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phosphatidylinositol acyl-chain remodeling [GO:0036149]; phospholipid biosynthetic process [GO:0008654]; positive regulation of fatty acid biosynthetic process [GO:0045723]; triglyceride biosynthetic process [GO:0019432] | cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] | 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 2-acylglycerol O-acyltransferase activity [GO:0003846]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; 2-acylglycerophosphocholine O-acyltransferase activity [GO:0047190]; acyltransferase activity [GO:0016746]; lysophosphatidylethanolamine acyltransferase activity [GO:0071618]; lysophospholipid acyltransferase activity [GO:0071617] | 8322.90692604684 | -0.418380857412866 | 0.110228167530344 | 0.310165658620336 |
| O75352 | O75352 | MPU1_HUMAN | Mannose-P-dolichol utilization defect 1 protein (Suppressor of Lec15 and Lec35 glycosylation mutation homolog) (SL15) | MPDU1 | dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; oligosaccharide biosynthetic process [GO:0009312]; protein folding [GO:0006457] | endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] | 5016.8657084181505 | -4.07190392836965 | 0.110319563421562 | 0.310165658620336 | |
| Q6R327 | Q6R327 | RICTR_HUMAN | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | RICTOR | actin cytoskeleton organization [GO:0030036]; cellular response to nutrient levels [GO:0031669]; cytoskeleton organization [GO:0007010]; embryo development ending in birth or egg hatching [GO:0009792]; negative regulation of apoptotic process [GO:0043066]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell growth [GO:0030307]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of TOR signaling [GO:0032008]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of establishment of cell polarity [GO:2000114]; regulation of gene expression [GO:0010468]; regulation of inflammatory response [GO:0050727]; regulation of peptidyl-serine phosphorylation [GO:0033135]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; TORC2 signaling [GO:0038203] | cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; TORC2 complex [GO:0031932] | molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; ribosome binding [GO:0043022] | 3727.89563467342 | -0.753970403877864 | 0.110196859740596 | 0.310165658620336 |
| Q99598 | Q99598 | TSNAX_HUMAN | Translin-associated protein X (Translin-associated factor X) | TSNAX | cell differentiation [GO:0030154]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; siRNA processing [GO:0030422]; spermatogenesis [GO:0007283] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoribonuclease complex [GO:1902555]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] | A2A adenosine receptor binding [GO:0031687]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; sequence-specific DNA binding [GO:0043565]; single-stranded DNA binding [GO:0003697] | 19516.70209276635 | 0.220948029538299 | 0.110358977723014 | 0.310165658620336 |
| P61077;P62837 | P61077 | UB2D3_HUMAN | Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3) | UBE2D3 | apoptotic process [GO:0006915]; DNA repair [GO:0006281]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein targeting to mitochondrion [GO:1903955]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein modification process [GO:0036211]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] | cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151] | ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842] | 198538.8879356055 | 0.514006235381797 | 0.110330818115044 | 0.310165658620336 |
| O75844 | O75844 | FACE1_HUMAN | CAAX prenyl protease 1 homolog (EC 3.4.24.84) (Farnesylated proteins-converting enzyme 1) (FACE-1) (Prenyl protein-specific endoprotease 1) (Zinc metalloproteinase Ste24 homolog) | ZMPSTE24 | adult walking behavior [GO:0007628]; bone mineralization [GO:0030282]; CAAX-box protein processing [GO:0071586]; calcium ion import into sarcoplasmic reticulum [GO:1990036]; CAMKK-AMPK signaling cascade [GO:0061762]; cardiac conduction [GO:0061337]; cardiac muscle cell development [GO:0055013]; cardiac ventricle development [GO:0003231]; cellular lipid metabolic process [GO:0044255]; cellular response to gamma radiation [GO:0071480]; determination of adult lifespan [GO:0008340]; DNA repair [GO:0006281]; growth plate cartilage development [GO:0003417]; hair follicle development [GO:0001942]; heart morphogenesis [GO:0003007]; inflammatory cell apoptotic process [GO:0006925]; kidney morphogenesis [GO:0060993]; liver development [GO:0001889]; maintenance of rDNA [GO:0043007]; multicellular organism growth [GO:0035264]; negative regulation of miRNA processing [GO:1903799]; neuromuscular process [GO:0050905]; nuclear envelope organization [GO:0006998]; positive regulation of gene expression via CpG island demethylation [GO:0044029]; prenylated protein catabolic process [GO:0030327]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; regulation of autophagy [GO:0010506]; regulation of bone mineralization [GO:0030500]; regulation of cell shape [GO:0008360]; regulation of cellular senescence [GO:2000772]; regulation of defense response to virus [GO:0050688]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of fibroblast proliferation [GO:0048145]; regulation of glucose metabolic process [GO:0010906]; regulation of hormone metabolic process [GO:0032350]; regulation of lipid metabolic process [GO:0019216]; regulation of mitotic cell cycle DNA replication [GO:1903463]; regulation of multicellular organism growth [GO:0040014]; regulation of stress-activated protein kinase signaling cascade [GO:0070302]; regulation of termination of RNA polymerase I transcription [GO:2000730]; regulation of TOR signaling [GO:0032006]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to DNA damage checkpoint signaling [GO:0072423]; thymus development [GO:0048538]; ventricular cardiac muscle tissue development [GO:0003229] | early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; protein-containing complex [GO:0032991] | double-stranded DNA binding [GO:0003690]; endopeptidase activity [GO:0004175]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metalloexopeptidase activity [GO:0008235] | 20003.466056685502 | -0.117069335126981 | 0.110175088837209 | 0.310165658620336 |
| Q9UNW9 | Q9UNW9 | NOVA2_HUMAN | RNA-binding protein Nova-2 (Astrocytic NOVA1-like RNA-binding protein) (Neuro-oncological ventral antigen 2) | NOVA2 | central nervous system neuron development [GO:0021954]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of cold-induced thermogenesis [GO:0120163]; neuron differentiation [GO:0030182]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of axon guidance [GO:1902667]; regulation of RNA metabolic process [GO:0051252] | cytoplasm [GO:0005737]; nucleus [GO:0005634] | mRNA binding [GO:0003729]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825] | 2879.2674439777 | -0.516193927960495 | 0.110417731321857 | 0.310176928938841 |
| Q9Y237 | Q9Y237 | PIN4_HUMAN | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (EC 5.2.1.8) (Parvulin-14) (Par14) (hPar14) (Parvulin-17) (Par17) (hPar17) (Peptidyl-prolyl cis-trans isomerase Pin4) (PPIase Pin4) (Peptidyl-prolyl cis/trans isomerase EPVH) (hEPVH) (Rotamase Pin4) | PIN4 | localization [GO:0051179]; rRNA processing [GO:0006364] | chromosome [GO:0005694]; cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome [GO:0030684]; spindle [GO:0005819] | bent DNA binding [GO:0003681]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723] | 42181.413833197395 | 0.307589396462203 | 0.110611056965194 | 0.31025853899247 |
| Q9NY27 | Q9NY27 | PP4R2_HUMAN | Serine/threonine-protein phosphatase 4 regulatory subunit 2 | PPP4R2 | mRNA processing [GO:0006397]; protein modification process [GO:0036211]; regulation of double-strand break repair [GO:2000779]; regulation of double-strand break repair via homologous recombination [GO:0010569]; RNA splicing [GO:0008380] | centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase 4 complex [GO:0030289] | protein phosphatase regulator activity [GO:0019888]; protein-macromolecule adaptor activity [GO:0030674] | 7864.176370160811 | 0.325217490897728 | 0.110544593002891 | 0.31025853899247 |
| P05386 | P05386 | RLA1_HUMAN | Large ribosomal subunit protein P1 (60S acidic ribosomal protein P1) | RPLP1 | cytoplasmic translation [GO:0002181]; translation [GO:0006412]; translational elongation [GO:0006414] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925] | protein kinase activator activity [GO:0030295]; ribonucleoprotein complex binding [GO:0043021]; structural constituent of ribosome [GO:0003735] | 331226.42403304495 | 0.395884865510939 | 0.110561029726557 | 0.31025853899247 |
| Q86VP1 | Q86VP1 | TAXB1_HUMAN | Tax1-binding protein 1 (TRAF6-binding protein) | TAX1BP1 | apoptotic process [GO:0006915]; autophagy [GO:0006914]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cytoplasmic pattern recognition receptor signaling pathway [GO:0039532]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; protein localization to phagocytic vesicle [GO:1905161] | autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; phagophore assembly site [GO:0000407] | kinase binding [GO:0019900]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674] | 10186.437116890686 | -0.219800576954142 | 0.111202162540007 | 0.311608038057212 |
| Q96BW5 | Q96BW5 | PTER_HUMAN | Phosphotriesterase-related protein (EC 3.1.-.-) (Parathion hydrolase-related protein) (hPHRP) | PTER | catabolic process [GO:0009056]; epithelial cell differentiation [GO:0030855] | extracellular exosome [GO:0070062] | hydrolase activity, acting on ester bonds [GO:0016788]; zinc ion binding [GO:0008270] | 14448.9316314641 | -0.175948655922644 | 0.111506230683252 | 0.31230037685371 |
| P31946 | P31946 | 1433B_HUMAN | 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed] | YWHAB | cytoplasmic sequestering of protein [GO:0051220]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of protein dephosphorylation [GO:0035308]; positive regulation of catalytic activity [GO:0043085]; protein targeting [GO:0006605]; signal transduction [GO:0007165] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; melanosome [GO:0042470]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; vacuolar membrane [GO:0005774] | cadherin binding [GO:0045296]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; phosphoprotein binding [GO:0051219]; phosphoserine residue binding [GO:0050815]; protein domain specific binding [GO:0019904]; protein kinase inhibitor activity [GO:0004860] | 188444.8314127525 | 0.236685518736295 | 0.111559471011632 | 0.31230037685371 |
| O60476 | O60476 | MA1A2_HUMAN | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (EC 3.2.1.113) (Mannosidase alpha class 1A member 2) (Processing alpha-1,2-mannosidase IB) (Alpha-1,2-mannosidase IB) | MAN1A2 | carbohydrate metabolic process [GO:0005975]; lung alveolus development [GO:0048286]; N-glycan processing [GO:0006491]; protein glycosylation [GO:0006486]; respiratory gaseous exchange by respiratory system [GO:0007585] | endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020] | calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571] | 8801.340826739115 | 0.341811885305131 | 0.111764730925879 | 0.312720476753595 |
| Q7Z4H3 | Q7Z4H3 | HDDC2_HUMAN | 5'-deoxynucleotidase HDDC2 (EC 3.1.3.89) (HD domain-containing protein 2) (Hepatitis C virus NS5A-transactivated protein 2) (HCV NS5A-transactivated protein 2) | HDDC2 | cytoplasm [GO:0005737] | 5'-deoxynucleotidase activity [GO:0002953]; metal ion binding [GO:0046872] | 18734.3727656023 | 0.555339011974111 | 0.111997654087325 | 0.31306300348238 | |
| P30038 | P30038 | AL4A1_HUMAN | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 4 member A1) (L-glutamate gamma-semialdehyde dehydrogenase) | ALDH4A1 | 4-hydroxyproline catabolic process [GO:0019470]; proline catabolic process [GO:0006562]; proline catabolic process to glutamate [GO:0010133]; proline metabolic process [GO:0006560] | cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] | 1-pyrroline-5-carboxylate dehydrogenase activity [GO:0003842]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; electron transfer activity [GO:0009055]; identical protein binding [GO:0042802] | 9851.217557586495 | 0.241893023742014 | 0.112235999405063 | 0.313544857650852 |
| Q9UBV7 | Q9UBV7 | B4GT7_HUMAN | Beta-1,4-galactosyltransferase 7 (Beta-1,4-GalTase 7) (Beta4Gal-T7) (b4Gal-T7) (EC 2.4.1.-) (Proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7) (UDP-galactose:beta-xylose beta-1,4-galactosyltransferase) (XGPT) (XGalT-1) (Xylosylprotein 4-beta-galactosyltransferase) (EC 2.4.1.133) (Xylosylprotein beta-1,4-galactosyltransferase) | B4GALT7 | carbohydrate metabolic process [GO:0005975]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan metabolic process [GO:0030203]; glycosylation [GO:0070085]; negative regulation of fibroblast proliferation [GO:0048147]; protein modification process [GO:0036211]; protein N-linked glycosylation [GO:0006487]; proteoglycan biosynthetic process [GO:0030166]; proteoglycan metabolic process [GO:0006029]; supramolecular fiber organization [GO:0097435] | Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020] | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831]; galactosyltransferase activity [GO:0008378]; manganese ion binding [GO:0030145]; xylosylprotein 4-beta-galactosyltransferase activity [GO:0046525] | 29044.20705515685 | 0.136025307138509 | 0.112280712349732 | 0.313544857650852 |
| P30530 | P30530 | UFO_HUMAN | Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene) | AXL | animal organ regeneration [GO:0031100]; blood vessel remodeling [GO:0001974]; cell maturation [GO:0048469]; cell migration [GO:0016477]; cellular response to extracellular stimulus [GO:0031668]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to interferon-alpha [GO:0035457]; cellular response to lipopolysaccharide [GO:0071222]; dendritic cell differentiation [GO:0097028]; erythrocyte homeostasis [GO:0034101]; establishment of localization in cell [GO:0051649]; forebrain cell migration [GO:0021885]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; natural killer cell differentiation [GO:0001779]; negative regulation of apoptotic process [GO:0043066]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of lymphocyte activation [GO:0051250]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; nervous system development [GO:0007399]; neuron apoptotic process [GO:0051402]; neuron migration [GO:0001764]; neutrophil clearance [GO:0097350]; ovulation cycle [GO:0042698]; phagocytosis [GO:0006909]; phosphorylation [GO:0016310]; platelet activation [GO:0030168]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of pinocytosis [GO:0048549]; positive regulation of viral life cycle [GO:1903902]; response to axon injury [GO:0048678]; secretion by cell [GO:0032940]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]; substrate adhesion-dependent cell spreading [GO:0034446]; symbiont entry into host cell [GO:0046718]; vagina development [GO:0060068]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] | actin cytoskeleton [GO:0015629]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] | ATP binding [GO:0005524]; myosin heavy chain binding [GO:0032036]; phosphatidylinositol 3-kinase binding [GO:0043548]; phosphatidylserine binding [GO:0001786]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; virus receptor activity [GO:0001618] | 13382.4556222991 | 0.178785604427122 | 0.112882053226638 | 0.315068824424696 |
| Q8WUZ0 | Q8WUZ0 | BCL7C_HUMAN | B-cell CLL/lymphoma 7 protein family member C | BCL7C | apoptotic process [GO:0006915]; chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357] | chromatin [GO:0000785]; GBAF complex [GO:0140288]; SWI/SNF complex [GO:0016514] | 44955.12878832845 | 0.28229909730015 | 0.112969430077266 | 0.315157454858586 | |
| P55263 | P55263 | ADK_HUMAN | Adenosine kinase (AK) (EC 2.7.1.20) (Adenosine 5'-phosphotransferase) | ADK | AMP salvage [GO:0044209]; dAMP salvage [GO:0106383]; dATP biosynthetic process [GO:0006175]; GMP salvage [GO:0032263]; phosphorylation [GO:0016310]; purine nucleobase metabolic process [GO:0006144]; purine ribonucleoside salvage [GO:0006166]; ribonucleoside monophosphate biosynthetic process [GO:0009156] | cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | adenosine kinase activity [GO:0004001]; ATP binding [GO:0005524]; deoxyadenosine kinase activity [GO:0004136]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] | 23897.894856053303 | 0.228645549635263 | 0.113167001476369 | 0.315553262974953 |
| P53611 | P53611 | PGTB2_HUMAN | Geranylgeranyl transferase type-2 subunit beta (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit beta) (GGTase-II-beta) (Rab geranyl-geranyltransferase subunit beta) (Rab GG transferase beta) (Rab GGTase beta) (Rab geranylgeranyltransferase subunit beta) (Type II protein geranyl-geranyltransferase subunit beta) | RABGGTB | protein geranylgeranylation [GO:0018344]; protein modification process [GO:0036211]; visual perception [GO:0007601] | cytosol [GO:0005829]; plasma membrane [GO:0005886]; Rab-protein geranylgeranyltransferase complex [GO:0005968] | Rab geranylgeranyltransferase activity [GO:0004663]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270] | 15203.6914585239 | -0.266171856759649 | 0.11360034053988 | 0.316605769551874 |
| Q6NZY7 | Q6NZY7 | BORG3_HUMAN | Cdc42 effector protein 5 (Binder of Rho GTPases 3) | CDC42EP5 | JNK cascade [GO:0007254]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of pseudopodium assembly [GO:0031274]; regulation of cell shape [GO:0008360]; Rho protein signal transduction [GO:0007266] | cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; plasma membrane [GO:0005886] | small GTPase binding [GO:0031267] | 19792.3361504106 | -0.353783731952512 | 0.114506865220658 | 0.318818623263021 |
| Q9Y2Y0 | Q9Y2Y0 | AR2BP_HUMAN | ADP-ribosylation factor-like protein 2-binding protein (ARF-like 2-binding protein) (ARL2-binding protein) (Binder of ARF2 protein 1) | ARL2BP | maintenance of protein location in nucleus [GO:0051457]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; signal transduction [GO:0007165] | centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; midbody [GO:0030496]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654]; spindle [GO:0005819] | GTPase regulator activity [GO:0030695]; transcription coactivator activity [GO:0003713] | 9953.602383935246 | -0.339205310059243 | 0.114585896191624 | 0.318829889540457 |
| Q15691 | Q15691 | MARE1_HUMAN | Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1) | MAPRE1 | attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; cell migration [GO:0016477]; establishment of mitotic spindle orientation [GO:0000132]; microtubule bundle formation [GO:0001578]; microtubule polymerization [GO:0046785]; negative regulation of microtubule polymerization [GO:0031115]; non-motile cilium assembly [GO:1905515]; positive regulation of microtubule polymerization [GO:0031116]; protein localization [GO:0008104]; protein localization to astral microtubule [GO:1902888]; protein localization to centrosome [GO:0071539]; protein localization to microtubule [GO:0035372]; regulation of microtubule polymerization or depolymerization [GO:0031110]; spindle assembly [GO:0051225] | cell projection membrane [GO:0031253]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cortical microtubule cytoskeleton [GO:0030981]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; microtubule plus-end [GO:0035371]; mitotic spindle astral microtubule end [GO:1905721]; mitotic spindle pole [GO:0097431]; spindle midzone [GO:0051233] | cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; microtubule plus-end binding [GO:0051010]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723] | 64102.66642902605 | 0.262571084575448 | 0.114623453052226 | 0.318829889540457 |
| P14618 | P14618 | KPYM_HUMAN | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | PKM | canonical glycolysis [GO:0061621]; cellular response to insulin stimulus [GO:0032869]; glycolytic process [GO:0006096]; phosphorylation [GO:0016310]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; programmed cell death [GO:0012501] | cilium [GO:0005929]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; ficolin-1-rich granule lumen [GO:1904813]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; rough endoplasmic reticulum [GO:0005791]; secretory granule lumen [GO:0034774]; vesicle [GO:0031982] | ATP binding [GO:0005524]; cadherin binding [GO:0045296]; histone H3T11 kinase activity [GO:0035402]; magnesium ion binding [GO:0000287]; MHC class II protein complex binding [GO:0023026]; mRNA binding [GO:0003729]; potassium ion binding [GO:0030955]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase activity [GO:0004713]; pyruvate kinase activity [GO:0004743]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713] | 748400.94358769 | 0.1131352256033 | 0.114947392725731 | 0.319417325740065 |
| Q9UQE7 | Q9UQE7 | SMC3_HUMAN | Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) | SMC3 | cell division [GO:0051301]; DNA repair [GO:0006281]; establishment of meiotic sister chromatid cohesion [GO:0034089]; establishment of mitotic sister chromatid cohesion [GO:0034087]; meiotic cell cycle [GO:0051321]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid cohesion [GO:0007064]; mitotic spindle assembly [GO:0090307]; regulation of DNA replication [GO:0006275]; sister chromatid cohesion [GO:0007062]; stem cell population maintenance [GO:0019827] | chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; cytosol [GO:0005829]; lateral element [GO:0000800]; meiotic cohesin complex [GO:0030893]; mitotic cohesin complex [GO:0030892]; mitotic spindle pole [GO:0097431]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; beta-tubulin binding [GO:0048487]; chromatin binding [GO:0003682]; cohesin loader activity [GO:0061775]; double-stranded DNA binding [GO:0003690]; dynein complex binding [GO:0070840]; mediator complex binding [GO:0036033]; microtubule motor activity [GO:0003777]; protein heterodimerization activity [GO:0046982] | 7662.87607969589 | -0.188378583752032 | 0.114913581194531 | 0.319417325740065 |
| O95721 | O95721 | SNP29_HUMAN | Synaptosomal-associated protein 29 (SNAP-29) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29) | SNAP29 | autophagosome maturation [GO:0097352]; autophagosome membrane docking [GO:0016240]; cilium assembly [GO:0060271]; exocytosis [GO:0006887]; membrane fusion [GO:0061025]; protein transport [GO:0015031]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle priming [GO:0016082]; vesicle targeting [GO:0006903] | autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; azurophil granule membrane [GO:0035577]; centrosome [GO:0005813]; ciliary pocket membrane [GO:0020018]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; SNARE complex [GO:0031201] | SNAP receptor activity [GO:0005484]; syntaxin binding [GO:0019905] | 31823.596351934248 | 0.332472653001959 | 0.115083550787144 | 0.319638920960765 |
| O00232 | O00232 | PSD12_HUMAN | 26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit RPN5) (26S proteasome regulatory subunit p55) | PSMD12 | proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; proteasome regulatory particle, lid subcomplex [GO:0008541]; secretory granule lumen [GO:0034774] | 71553.78193388009 | 0.142574542673462 | 0.115578327917492 | 0.320855857903237 | |
| O14498 | O14498 | ISLR_HUMAN | Immunoglobulin superfamily containing leucine-rich repeat protein | ISLR | cell adhesion [GO:0007155] | extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; platelet alpha granule lumen [GO:0031093] | 20477.535151710348 | 0.225007669780669 | 0.115790716632657 | 0.321288051146245 | |
| Q9UHL4 | Q9UHL4 | DPP2_HUMAN | Dipeptidyl peptidase 2 (EC 3.4.14.2) (Dipeptidyl aminopeptidase II) (Dipeptidyl peptidase 7) (Dipeptidyl peptidase II) (DPP II) (Quiescent cell proline dipeptidase) | DPP7 | lysosomal protein catabolic process [GO:1905146]; proteolysis [GO:0006508] | azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; vesicle [GO:0031982] | aminopeptidase activity [GO:0004177]; dipeptidyl-peptidase activity [GO:0008239]; serine-type exopeptidase activity [GO:0070008]; serine-type peptidase activity [GO:0008236] | 55203.1395971419 | 0.153299549350837 | 0.116269425094558 | 0.322334385518924 |
| Q5JTH9 | Q5JTH9 | RRP12_HUMAN | RRP12-like protein | RRP12 | rRNA processing [GO:0006364] | cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] | RNA binding [GO:0003723] | 5271.944786102929 | -0.442916140284216 | 0.116281589128253 | 0.322334385518924 |
| P17980 | P17980 | PRS6A_HUMAN | 26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1) | PSMC3 | modulation by host of viral transcription [GO:0043921]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] | cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]; secretory granule lumen [GO:0034774] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; proteasome-activating activity [GO:0036402] | 51933.2673742027 | 0.148955990860741 | 0.116380217351153 | 0.322450030079038 |
| Q9BQ69 | Q9BQ69 | MACD1_HUMAN | ADP-ribose glycohydrolase MACROD1 (MACRO domain-containing protein 1) (O-acetyl-ADP-ribose deacetylase MACROD1) (EC 3.1.1.106) (Protein LRP16) ([Protein ADP-ribosylaspartate] hydrolase MACROD1) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD1) (EC 3.2.2.-) | MACROD1 | DNA damage response [GO:0006974]; peptidyl-glutamate ADP-deribosylation [GO:0140291]; protein de-ADP-ribosylation [GO:0051725]; purine nucleoside metabolic process [GO:0042278] | nucleoplasm [GO:0005654]; nucleus [GO:0005634] | ADP-ribosylglutamate hydrolase activity [GO:0140293]; deacetylase activity [GO:0019213]; hydrolase activity, acting on glycosyl bonds [GO:0016798] | 3437.667313310195 | -0.638551699765805 | 0.116714966034066 | 0.323061552295564 |
| Q8TAA9 | Q8TAA9 | VANG1_HUMAN | Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1) | VANGL1 | pigmentation [GO:0043473]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071] | lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886] | 15456.031221027351 | 0.173296004537617 | 0.116949286858458 | 0.323552079755871 | |
| P68363 | P68363 | TBA1B_HUMAN | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | TUBA1B | cell division [GO:0051301]; cellular response to interleukin-4 [GO:0071353]; cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278] | cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630] | double-stranded RNA binding [GO:0003725]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; ubiquitin protein ligase binding [GO:0031625] | 530803.8655389245 | 0.123925630777454 | 0.117027089107368 | 0.323609315218324 |
| P11766 | P11766 | ADHX_HUMAN | Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase class chi chain) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) | ADH5 | ethanol oxidation [GO:0006069]; fatty acid omega-oxidation [GO:0010430]; formaldehyde catabolic process [GO:0046294]; positive regulation of blood pressure [GO:0045777]; respiratory system process [GO:0003016]; response to lipopolysaccharide [GO:0032496]; response to nitrosative stress [GO:0051409]; response to redox state [GO:0051775]; retinoid metabolic process [GO:0001523] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739] | alcohol dehydrogenase activity, zinc-dependent [GO:0004024]; electron transfer activity [GO:0009055]; fatty acid binding [GO:0005504]; formaldehyde dehydrogenase activity [GO:0018467]; identical protein binding [GO:0042802]; S-(hydroxymethyl)glutathione dehydrogenase activity [GO:0051903]; S-(hydroxymethyl)glutathione dehydrogenase NAD activity [GO:0106322]; S-(hydroxymethyl)glutathione dehydrogenase NADP activity [GO:0106321]; zinc ion binding [GO:0008270] | 50325.83391645745 | -0.123789061601305 | 0.117517048615723 | 0.324682105542369 |
| Q8IZH2 | Q8IZH2 | XRN1_HUMAN | 5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog) | XRN1 | cellular response to cycloheximide [GO:0071409]; cellular response to puromycin [GO:1905795]; histone mRNA catabolic process [GO:0071044]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of translation [GO:0017148]; nuclear mRNA surveillance [GO:0071028]; nuclear-transcribed mRNA catabolic process [GO:0000956]; response to testosterone [GO:0033574]; rRNA catabolic process [GO:0016075] | cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; P-body [GO:0000932]; plasma membrane [GO:0005886] | 5'-3' RNA exonuclease activity [GO:0004534]; G-quadruplex DNA binding [GO:0051880]; G-quadruplex RNA binding [GO:0002151]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034] | 8557.59521923932 | -0.291223417306704 | 0.117529650276632 | 0.324682105542369 |
| A2RRP1 | A2RRP1 | NBAS_HUMAN | NBAS subunit of NRZ tethering complex (Neuroblastoma-amplified gene protein) (Neuroblastoma-amplified sequence) | NBAS | negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process [GO:0000956]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890] | cytosol [GO:0005829]; Dsl1/NZR complex [GO:0070939]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] | SNARE binding [GO:0000149] | 5032.991783421825 | -0.411963217408489 | 0.118540990671252 | 0.327316400167307 |
| Q9UKV5 | Q9UKV5 | AMFR_HUMAN | E3 ubiquitin-protein ligase AMFR (EC 2.3.2.36) (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (gp78) | AMFR | endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; learning or memory [GO:0007611]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of plant-type hypersensitive response [GO:0034052]; protein autoubiquitination [GO:0051865]; protein K27-linked ubiquitination [GO:0044314]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; regulation of SREBP signaling pathway [GO:2000638]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway [GO:0016055] | cytosol [GO:0005829]; dendrite [GO:0030425]; Derlin-1 retrotranslocation complex [GO:0036513]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ubiquitin ligase complex [GO:0000151] | BAT3 complex binding [GO:1904288]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor activity [GO:0038023]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-specific protease binding [GO:1990381]; ubiquitin-ubiquitin ligase activity [GO:0034450] | 12516.6303568677 | 0.541408035033724 | 0.11876879180046 | 0.327785666995326 |
| O14980 | O14980 | XPO1_HUMAN | Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog) | XPO1 | mRNA export from nucleus [GO:0006406]; nucleocytoplasmic transport [GO:0006913]; protein export from nucleus [GO:0006611]; protein localization to nucleus [GO:0034504]; regulation of centrosome duplication [GO:0010824]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of protein export from nucleus [GO:0046825]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit export from nucleus [GO:0000056]; ribosomal subunit export from nucleus [GO:0000054]; ribosome biogenesis [GO:0042254] | annulate lamellae [GO:0005642]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904] | nuclear export signal receptor activity [GO:0005049]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267] | 18600.77506949465 | -0.242438152763128 | 0.119214688704036 | 0.328856098440637 |
| Q5TC12 | Q5TC12 | ATPF1_HUMAN | ATP synthase mitochondrial F1 complex assembly factor 1 (ATP11 homolog) | ATPAF1 | mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615] | mitochondrion [GO:0005739] | 5518.145847121135 | 0.140700129748714 | 0.119714214186527 | 0.32955673389082 | |
| P53634 | P53634 | CATC_HUMAN | Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)] | CTSC | immune response [GO:0006955]; negative regulation of myelination [GO:0031642]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of proteolysis involved in protein catabolic process [GO:1903052]; proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603]; response to organic substance [GO:0010033]; T cell mediated cytotoxicity [GO:0001913] | azurophil granule lumen [GO:0035578]; centrosome [GO:0005813]; collagen-containing extracellular matrix [GO:0062023]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleoplasm [GO:0005654] | chloride ion binding [GO:0031404]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; dipeptidyl-peptidase activity [GO:0008239]; identical protein binding [GO:0042802]; peptidase activator activity involved in apoptotic process [GO:0016505]; phosphatase binding [GO:0019902]; protein self-association [GO:0043621]; protein-folding chaperone binding [GO:0051087]; serine-type endopeptidase activity [GO:0004252] | 28682.90876189515 | 0.287373036257942 | 0.119759497896435 | 0.32955673389082 |
| P16083 | P16083 | NQO2_HUMAN | Ribosyldihydronicotinamide dehydrogenase [quinone] (EC 1.10.5.1) (NRH dehydrogenase [quinone] 2) (NRH:quinone oxidoreductase 2) (Quinone reductase 2) (QR2) | NQO2 | quinone catabolic process [GO:1901662] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654] | chloride ion binding [GO:0031404]; dihydronicotinamide riboside quinone reductase activity [GO:0001512]; electron transfer activity [GO:0009055]; FAD binding [GO:0071949]; melatonin binding [GO:1904408]; NAD(P)H dehydrogenase (quinone) activity [GO:0003955]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on other nitrogenous compounds as donors [GO:0016661]; protein homodimerization activity [GO:0042803]; resveratrol binding [GO:1905594]; zinc ion binding [GO:0008270] | 10463.779787396401 | 0.286493371199333 | 0.119755586463145 | 0.32955673389082 |
| Q15628 | Q15628 | TRADD_HUMAN | Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain) | TRADD | apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to tumor necrosis factor [GO:0071356]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of hair follicle development [GO:0051798]; positive regulation of inflammatory response [GO:0050729]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; signal transduction [GO:0007165]; tumor necrosis factor-mediated signaling pathway [GO:0033209] | cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; tumor necrosis factor receptor superfamily complex [GO:0002947] | death domain binding [GO:0070513]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; protein-containing complex binding [GO:0044877]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]; tumor necrosis factor receptor binding [GO:0005164] | 17041.1008379247 | 0.167741798847697 | 0.119588610203616 | 0.32955673389082 |
| Q9H4L4 | Q9H4L4 | SENP3_HUMAN | Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) | SENP3 | negative regulation of double-strand break repair via homologous recombination [GO:2000042]; protein desumoylation [GO:0016926]; proteolysis [GO:0006508] | cytoplasm [GO:0005737]; MLL1 complex [GO:0071339]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type peptidase activity [GO:0008234]; deSUMOylase activity [GO:0016929] | 9348.9104465061 | -0.648020524587449 | 0.120100027307775 | 0.330333376080512 |
| P84098 | P84098 | RL19_HUMAN | Large ribosomal subunit protein eL19 (60S ribosomal protein L19) | RPL19 | cytoplasmic translation [GO:0002181]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; synapse [GO:0045202] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 85430.91291708339 | 0.209847576385731 | 0.120831319506958 | 0.332183530483466 |
| Q9NV92 | Q9NV92 | NFIP2_HUMAN | NEDD4 family-interacting protein 2 (NEDD4 WW domain-binding protein 5A) (Putative MAPK-activating protein PM04/PM05/PM06/PM07) (Putative NF-kappa-B-activating protein 413) | NDFIP2 | metal ion transport [GO:0030001]; negative regulation of gene expression [GO:0010629]; negative regulation of protein transport [GO:0051224]; negative regulation of transporter activity [GO:0032410]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein ubiquitination [GO:0031398]; ubiquitin-dependent protein catabolic process [GO:0006511]; vacuolar transport [GO:0007034] | cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; multivesicular body membrane [GO:0032585]; perinuclear region of cytoplasm [GO:0048471] | WW domain binding [GO:0050699] | 3365.927319684525 | -1.54365474721063 | 0.121008639656163 | 0.332509676184199 |
| Q08AF3 | Q08AF3 | SLFN5_HUMAN | Schlafen family member 5 | SLFN5 | cell differentiation [GO:0030154] | nucleus [GO:0005634] | ATP binding [GO:0005524] | 7885.90829929671 | -0.26418242374374 | 0.121449371574613 | 0.333558962356645 |
| Q96GX9 | Q96GX9 | MTNB_HUMAN | Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase) (EC 4.2.1.109) (APAF1-interacting protein) (hAPIP) | APIP | apoptotic process [GO:0006915]; L-methionine salvage from methylthioadenosine [GO:0019509]; L-methionine salvage from S-adenosylmethionine [GO:0019284]; negative regulation of apoptotic process [GO:0043066]; protein homotetramerization [GO:0051289]; pyroptosis [GO:0070269]; regulation of ERK1 and ERK2 cascade [GO:0070372] | cytoplasm [GO:0005737]; cytosol [GO:0005829] | identical protein binding [GO:0042802]; methylthioribulose 1-phosphate dehydratase activity [GO:0046570]; zinc ion binding [GO:0008270] | 14153.4496755873 | 0.331997047719644 | 0.121706098593631 | 0.33410210980209 |
| P10909 | P10909 | CLUS_HUMAN | Clusterin (Aging-associated gene 4 protein) (Apolipoprotein J) (Apo-J) (Complement cytolysis inhibitor) (CLI) (Complement-associated protein SP-40,40) (Ku70-binding protein 1) (NA1/NA2) (Sulfated glycoprotein 2) (SGP-2) (Testosterone-repressed prostate message 2) (TRPM-2) [Cleaved into: Clusterin beta chain (ApoJalpha) (Complement cytolysis inhibitor a chain) (SP-40,40 beta-chain); Clusterin alpha chain (ApoJbeta) (Complement cytolysis inhibitor b chain) (SP-40,40 alpha-chain)] | CLU | cell morphogenesis [GO:0000902]; central nervous system myelin maintenance [GO:0032286]; chaperone-mediated protein complex assembly [GO:0051131]; chaperone-mediated protein folding [GO:0061077]; complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; immune complex clearance [GO:0002434]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway [GO:0097193]; lipid metabolic process [GO:0006629]; microglial cell activation [GO:0001774]; microglial cell proliferation [GO:0061518]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; positive regulation of amyloid fibril formation [GO:1905908]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of apoptotic process [GO:0043065]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of neurofibrillary tangle assembly [GO:1902998]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein import [GO:0017038]; protein stabilization [GO:0050821]; protein targeting to lysosome involved in chaperone-mediated autophagy [GO:0061740]; regulation of amyloid-beta clearance [GO:1900221]; regulation of apoptotic process [GO:0042981]; regulation of cell population proliferation [GO:0042127]; regulation of neuronal signal transduction [GO:1902847]; release of cytochrome c from mitochondria [GO:0001836]; response to misfolded protein [GO:0051788]; response to virus [GO:0009615]; reverse cholesterol transport [GO:0043691] | apical dendrite [GO:0097440]; blood microparticle [GO:0072562]; cell surface [GO:0009986]; chromaffin granule [GO:0042583]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; neurofibrillary tangle [GO:0097418]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum lumen [GO:0099020]; perinuclear region of cytoplasm [GO:0048471]; platelet alpha granule lumen [GO:0031093]; protein-containing complex [GO:0032991]; spherical high-density lipoprotein particle [GO:0034366]; synapse [GO:0045202] | amyloid-beta binding [GO:0001540]; low-density lipoprotein particle receptor binding [GO:0050750]; misfolded protein binding [GO:0051787]; protein carrier chaperone [GO:0140597]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; signaling receptor binding [GO:0005102]; tau protein binding [GO:0048156]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082] | 9152.64177743803 | 0.351876749349645 | 0.121797241421248 | 0.334190397042514 |
| Q14728 | Q14728 | MFS10_HUMAN | Major facilitator superfamily domain-containing protein 10 (Tetracycline transporter-like protein) | MFSD10 | apoptotic process [GO:0006915]; sodium-independent organic anion transport [GO:0043252] | brush border membrane [GO:0031526]; cytoplasmic vesicle membrane [GO:0030659]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637] | organic anion transmembrane transporter activity [GO:0008514]; tetracycline transmembrane transporter activity [GO:0008493] | 7356.72234612323 | -0.579460587077872 | 0.122012124652653 | 0.334456070770164 |
| Q12931 | Q12931 | TRAP1_HUMAN | Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) | TRAP1 | chaperone-mediated protein folding [GO:0061077]; negative regulation of cellular respiration [GO:1901856]; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:1903751]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; protein folding [GO:0006457]; translational attenuation [GO:0009386] | cell periphery [GO:0071944]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; tumor necrosis factor receptor binding [GO:0005164]; unfolded protein binding [GO:0051082] | 39058.3725867524 | 0.12465093705453 | 0.122008765876993 | 0.334456070770164 |
| O00767 | O00767 | SCD_HUMAN | Stearoyl-CoA desaturase (hSCD1) (EC 1.14.19.1) (Acyl-CoA desaturase) (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase) | SCD | monounsaturated fatty acid biosynthetic process [GO:1903966]; positive regulation of cold-induced thermogenesis [GO:0120162]; response to fatty acid [GO:0070542]; unsaturated fatty acid biosynthetic process [GO:0006636] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleolus [GO:0005730] | iron ion binding [GO:0005506]; oxidoreductase activity [GO:0016491]; palmitoyl-CoA 9-desaturase activity [GO:0032896]; stearoyl-CoA 9-desaturase activity [GO:0004768] | 78344.47712585324 | 0.210726878933489 | 0.122387572988425 | 0.335160941784638 |
| P61981 | P61981 | 1433G_HUMAN | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | YWHAG | cellular response to glucose starvation [GO:0042149]; cellular response to insulin stimulus [GO:0032869]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of TORC1 signaling [GO:1904262]; protein targeting [GO:0006605]; regulation of neuron differentiation [GO:0045664]; regulation of signal transduction [GO:0009966]; regulation of synaptic plasticity [GO:0048167]; signal transduction [GO:0007165] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; presynapse [GO:0098793] | identical protein binding [GO:0042802]; insulin-like growth factor receptor binding [GO:0005159]; phosphoserine residue binding [GO:0050815]; protein domain specific binding [GO:0019904]; protein kinase C binding [GO:0005080]; protein kinase C inhibitor activity [GO:0008426]; protein sequestering activity [GO:0140311]; receptor tyrosine kinase binding [GO:0030971]; RNA binding [GO:0003723] | 336527.03417657746 | 0.240196529971828 | 0.122351171618522 | 0.335160941784638 |
| Q8NBP0 | Q8NBP0 | TTC13_HUMAN | Tetratricopeptide repeat protein 13 (TPR repeat protein 13) | TTC13 | 6638.63834311641 | -0.242981543788632 | 0.122675385931239 | 0.335786829317102 | |||
| Q7Z7H5 | Q7Z7H5 | TMED4_HUMAN | Transmembrane emp24 domain-containing protein 4 (Endoplasmic reticulum stress-response protein 25) (ERS25) (GMP25iso) (Putative NF-kappa-B-activating protein 156) (p24 family protein alpha-3) (p24alpha3) | TMED4 | endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123] | COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794] | cargo receptor activity [GO:0038024] | 130728.742216514 | 0.313356404096727 | 0.122764446553493 | 0.335868350638382 |
| A6NKD9 | A6NKD9 | CC85C_HUMAN | Coiled-coil domain-containing protein 85C | CCDC85C | cerebral cortex development [GO:0021987] | adherens junction [GO:0005912]; apical junction complex [GO:0043296]; bicellular tight junction [GO:0005923] | 4635.3620589373 | -0.681674102256267 | 0.122853858121249 | 0.335950752951254 | |
| P56211 | P56211 | ARP19_HUMAN | cAMP-regulated phosphoprotein 19 (ARPP-19) | ARPP19 | cell division [GO:0051301]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic cell cycle [GO:0000278]; negative regulation of protein dephosphorylation [GO:0035308]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of glucose import [GO:0046326] | cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] | phosphatase inhibitor activity [GO:0019212]; potassium channel regulator activity [GO:0015459]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase inhibitor activity [GO:0004864]; protein phosphatase regulator activity [GO:0019888]; signaling receptor binding [GO:0005102] | 108493.2710078418 | 0.402529337787078 | 0.123068494732437 | 0.336317371987307 |
| Q08629 | Q08629 | TICN1_HUMAN | Testican-1 (Protein SPOCK) | SPOCK1 | cell adhesion [GO:0007155]; central nervous system neuron differentiation [GO:0021953]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of neuron projection development [GO:0010977]; nervous system development [GO:0007399]; neurogenesis [GO:0022008]; neuron migration [GO:0001764]; regulation of cell growth [GO:0001558] | cytoplasm [GO:0005737]; extracellular space [GO:0005615]; neuromuscular junction [GO:0031594]; node of Ranvier [GO:0033268]; postsynaptic density [GO:0014069]; sarcoplasm [GO:0016528] | calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; extracellular matrix binding [GO:0050840]; metalloendopeptidase inhibitor activity [GO:0008191]; serine-type endopeptidase inhibitor activity [GO:0004867] | 17716.423387478797 | -0.186837018988242 | 0.12366644658122 | 0.337521236189398 |
| O95202 | O95202 | LETM1_HUMAN | Mitochondrial proton/calcium exchanger protein (Electroneutral mitochondrial K(+)/H(+)exchanger) (KHE) (Leucine zipper-EF-hand-containing transmembrane protein 1) | LETM1 | calcium export from the mitochondrion [GO:0099093]; calcium ion transport [GO:0006816]; cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; mitochondrial potassium ion transmembrane transport [GO:0140141]; negative regulation of mitochondrial calcium ion concentration [GO:0051562]; protein hexamerization [GO:0034214]; protein homooligomerization [GO:0051260]; regulation of cellular hyperosmotic salinity response [GO:1900069] | mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] | calcium ion binding [GO:0005509]; calcium:proton antiporter activity [GO:0015369]; ribosome binding [GO:0043022] | 20525.538511616498 | 0.166330563886268 | 0.124185156884587 | 0.338704352078222 |
| Q96JG8 | Q96JG8 | MAGD4_HUMAN | Melanoma-associated antigen D4 (MAGE-D4 antigen) (MAGE-E1 antigen) | MAGED4; MAGED4B | negative regulation of transcription by RNA polymerase II [GO:0000122] | nucleus [GO:0005634] | 2300.7275117406753 | 0.467053281874429 | 0.12441778738472 | 0.338704352078222 | |
| Q9Y314 | Q9Y314 | NOSIP_HUMAN | Nitric oxide synthase-interacting protein (E3 ubiquitin-protein ligase NOSIP) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase NOSIP) (eNOS-interacting protein) | NOSIP | negative regulation of catalytic activity [GO:0043086]; negative regulation of nitric-oxide synthase activity [GO:0051001]; regulation of nitric oxide biosynthetic process [GO:0045428] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | molecular sequestering activity [GO:0140313]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630] | 9767.34130853129 | 0.245629500078789 | 0.124458605899551 | 0.338704352078222 |
| O00233 | O00233 | PSMD9_HUMAN | 26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27) | PSMD9 | negative regulation of insulin secretion [GO:0046676]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin secretion [GO:0032024]; proteasome regulatory particle assembly [GO:0070682]; ubiquitin-dependent protein catabolic process [GO:0006511] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome regulatory particle [GO:0005838] | bHLH transcription factor binding [GO:0043425]; transcription coactivator activity [GO:0003713] | 40425.16896199755 | 0.25110247416398 | 0.124289654209181 | 0.338704352078222 |
| Q96S55 | Q96S55 | WRIP1_HUMAN | ATPase WRNIP1 (EC 3.6.1.-) (Werner helicase-interacting protein 1) | WRNIP1 | DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; innate immune response [GO:0045087]; regulation of DNA-templated DNA replication initiation [GO:0030174] | membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; single-stranded DNA helicase activity [GO:0017116] | 2150.602909053985 | -0.709958241405115 | 0.12438765157159 | 0.338704352078222 |
| P10412 | P10412 | H14_HUMAN | Histone H1.4 (Histone H1b) (Histone H1s-4) | H1-4 | chromosome condensation [GO:0030261]; negative regulation of DNA recombination [GO:0045910]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleosome assembly [GO:0006334] | heterochromatin [GO:0000792]; nucleosome [GO:0000786]; nucleus [GO:0005634] | chromatin DNA binding [GO:0031490]; double-stranded DNA binding [GO:0003690]; histone deacetylase binding [GO:0042826]; nucleosomal DNA binding [GO:0031492]; RNA binding [GO:0003723]; structural constituent of chromatin [GO:0030527] | 192951.253393721 | -0.2271231161887 | 0.12467028204001 | 0.33879223886748 |
| Q9NRV9 | Q9NRV9 | HEBP1_HUMAN | Heme-binding protein 1 (p22HBP) | HEBP1 | circadian rhythm [GO:0007623] | cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576] | heme binding [GO:0020037] | 78034.897387896 | 0.252133538049468 | 0.124624876180572 | 0.33879223886748 |
| Q9NW82 | Q9NW82 | WDR70_HUMAN | WD repeat-containing protein 70 | WDR70 | nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] | enzyme binding [GO:0019899] | 4375.46770158092 | -0.329376757987097 | 0.124562600990298 | 0.33879223886748 | |
| Q9UKD2 | Q9UKD2 | MRT4_HUMAN | mRNA turnover protein 4 homolog (Ribosome assembly factor MRTO4) | MRTO4 | nuclear-transcribed mRNA catabolic process [GO:0000956]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364] | cytoplasm [GO:0005737]; nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687] | RNA binding [GO:0003723] | 21440.13736594125 | 0.226730069637805 | 0.125038425768822 | 0.339629779676964 |
| Q9BT22 | Q9BT22 | ALG1_HUMAN | Chitobiosyldiphosphodolichol beta-mannosyltransferase (EC 2.4.1.142) (Asparagine-linked glycosylation protein 1 homolog) (Beta-1,4-mannosyltransferase) (GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase) (GDP-mannose-dolichol diphosphochitobiose mannosyltransferase) (Mannosyltransferase-1) (MT-1) (hMat-1) | ALG1 | dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein glycosylation [GO:0006486] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] | chitobiosyldiphosphodolichol beta-mannosyltransferase activity [GO:0004578]; mannosyltransferase activity [GO:0000030] | 14690.85388963385 | -0.370650139000854 | 0.125103133508165 | 0.339642718954127 |
| P62899 | P62899 | RL31_HUMAN | Large ribosomal subunit protein eL31 (60S ribosomal protein L31) | RPL31 | cytoplasmic translation [GO:0002181]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 475696.83840591647 | 0.271506145484375 | 0.125388626662477 | 0.340254769477774 |
| Q5T1J5;Q9Y6H1 | Q5T1J5 | CHCH9_HUMAN | Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial (Coiled-coil-helix-coiled-coil-helix domain-containing 2 pseudogene 9) | CHCHD2P9 | mitochondrion organization [GO:0007005]; positive regulation of transcription by RNA polymerase II [GO:0045944] | mitochondrion [GO:0005739]; nucleus [GO:0005634] | sequence-specific DNA binding [GO:0043565] | 33871.83916452135 | 1.80658401762152 | 0.125465259015843 | 0.340299740346465 |
| P13798 | P13798 | ACPH_HUMAN | Acylamino-acid-releasing enzyme (AARE) (EC 3.4.19.1) (Acyl-peptide hydrolase) (APH) (Acylaminoacyl-peptidase) (Oxidized protein hydrolase) (OPH) | APEH | amyloid-beta metabolic process [GO:0050435]; proteolysis [GO:0006508]; translational termination [GO:0006415] | cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nuclear membrane [GO:0031965] | identical protein binding [GO:0042802]; omega peptidase activity [GO:0008242]; RNA binding [GO:0003723]; serine-type endopeptidase activity [GO:0004252] | 29698.056197300248 | -0.13859246466488 | 0.12563726970474 | 0.340603239304811 |
| Q8N3C0 | Q8N3C0 | ASCC3_HUMAN | Activating signal cointegrator 1 complex subunit 3 (EC 3.6.4.12) (ASC-1 complex subunit p200) (ASC1p200) (Helicase, ATP binding 1) (Trip4 complex subunit p200) | ASCC3 | cell population proliferation [GO:0008283]; DNA dealkylation involved in DNA repair [GO:0006307]; DNA duplex unwinding [GO:0032508]; rescue of stalled ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116] | activating signal cointegrator 1 complex [GO:0099053]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; DNA repair complex [GO:1990391]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723] | 7633.331884929325 | -0.298566736885799 | 0.12623421882757 | 0.341567852854352 |
| Q9BRP8 | Q9BRP8 | PYM1_HUMAN | Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog) | PYM1 | exon-exon junction complex disassembly [GO:1903259]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of translation [GO:0045727] | cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] | ribosome binding [GO:0043022]; RNA binding [GO:0003723] | 46795.3815523416 | 0.357736513018742 | 0.126214157514887 | 0.341567852854352 |
| Q9Y5B0 | Q9Y5B0 | CTDP1_HUMAN | RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase) | CTDP1 | cell division [GO:0051301]; exit from mitosis [GO:0010458]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; positive regulation by host of viral transcription [GO:0043923]; protein dephosphorylation [GO:0006470]; transcription elongation by RNA polymerase II [GO:0006368] | centrosome [GO:0005813]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; spindle midzone [GO:0051233]; spindle pole [GO:0000922] | myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]; Tat protein binding [GO:0030957]; TFIIF-class transcription factor complex binding [GO:0001096] | 6003.54080968959 | -0.315675444459826 | 0.126455454992528 | 0.341839984726939 |
| Q9H6T3 | Q9H6T3 | RPAP3_HUMAN | RNA polymerase II-associated protein 3 | RPAP3 | protein stabilization [GO:0050821] | cytosol [GO:0005829]; protein folding chaperone complex [GO:0101031]; R2TP complex [GO:0097255]; RPAP3/R2TP/prefoldin-like complex [GO:1990062] | 10230.214990164499 | 0.197159204635424 | 0.126434527816119 | 0.341839984726939 | |
| Q5UCC4 | Q5UCC4 | EMC10_HUMAN | ER membrane protein complex subunit 10 (Hematopoietic signal peptide-containing membrane domain-containing protein 1) | EMC10 | angiogenesis [GO:0001525]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816] | EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; membrane [GO:0016020] | 67356.96114311695 | 0.349444828332311 | 0.126688263436267 | 0.342306008884068 | |
| Q15011 | Q15011 | HERP1_HUMAN | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (Methyl methanesulfonate (MMF)-inducible fragment protein 1) | HERPUD1 | endoplasmic reticulum calcium ion homeostasis [GO:0032469]; endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein targeting to ER [GO:0045047]; regulation of ERAD pathway [GO:1904292]; regulation of protein ubiquitination [GO:0031396]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent protein catabolic process [GO:0006511] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; Lewy body core [GO:1990037]; membrane [GO:0016020] | transmembrane transporter binding [GO:0044325]; ubiquitin ligase-substrate adaptor activity [GO:1990756] | 11656.11076751825 | -0.167449087310021 | 0.127410174793899 | 0.343928561401731 |
| Q9HAU5 | Q9HAU5 | RENT2_HUMAN | Regulator of nonsense transcripts 2 (Up-frameshift suppressor 2 homolog) (hUpf2) | UPF2 | animal organ regeneration [GO:0031100]; liver development [GO:0001889]; mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184] | cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] | RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162] | 3735.48740926651 | -0.586319964130221 | 0.127532464679811 | 0.344094735655148 |
| Q96II8 | Q96II8 | LRCH3_HUMAN | DISP complex protein LRCH3 (Leucine-rich repeat and calponin homology domain-containing protein 3) | LRCH3 | septin cytoskeleton organization [GO:0032185] | cytoplasm [GO:0005737]; cytosol [GO:0005829] | 7007.06584114726 | -0.203960604211187 | 0.127602028302666 | 0.344118558954264 | |
| O14745 | O14745 | NHRF1_HUMAN | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) | NHERF1 | actin cytoskeleton organization [GO:0030036]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; auditory receptor cell stereocilium organization [GO:0060088]; bile acid secretion [GO:0032782]; cerebrospinal fluid circulation [GO:0090660]; cilium organization [GO:0044782]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of Golgi localization [GO:0051683]; fibroblast migration [GO:0010761]; gamma-aminobutyric acid import [GO:0051939]; gland morphogenesis [GO:0022612]; glutathione transport [GO:0034635]; import across plasma membrane [GO:0098739]; intracellular phosphate ion homeostasis [GO:0030643]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; microvillus assembly [GO:0030033]; morphogenesis of an epithelium [GO:0002009]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of sodium ion transport [GO:0010766]; nuclear migration [GO:0007097]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; plasma membrane organization [GO:0007009]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; protein localization to plasma membrane [GO:0072659]; protein-containing complex assembly [GO:0065003]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of protein kinase activity [GO:0045859]; regulation of renal phosphate excretion [GO:1903402]; renal absorption [GO:0070293]; renal phosphate ion absorption [GO:0097291]; renal sodium ion transport [GO:0003096]; sensory perception of sound [GO:0007605]; transport across blood-brain barrier [GO:0150104]; Wnt signaling pathway [GO:0016055] | actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; membrane [GO:0016020]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane protein complex [GO:0098797]; ruffle [GO:0001726]; sperm midpiece [GO:0097225]; stereocilium tip [GO:0032426]; vesicle [GO:0031982] | beta-2 adrenergic receptor binding [GO:0031698]; beta-catenin binding [GO:0008013]; channel activator activity [GO:0099103]; chloride channel regulator activity [GO:0017081]; dopamine receptor binding [GO:0050780]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; growth factor receptor binding [GO:0070851]; identical protein binding [GO:0042802]; myosin II binding [GO:0045159]; PDZ domain binding [GO:0030165]; phosphatase binding [GO:0019902]; protein self-association [GO:0043621]; protein-containing complex binding [GO:0044877]; protein-membrane adaptor activity [GO:0043495]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]; type 2 metabotropic glutamate receptor binding [GO:0031799]; type 3 metabotropic glutamate receptor binding [GO:0031800] | 10975.0216748368 | 0.228892450544351 | 0.127933783775605 | 0.344849105077345 |
| O95197 | O95197 | RTN3_HUMAN | Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII) | RTN3 | apoptotic process [GO:0006915]; brain development [GO:0007420]; endoplasmic reticulum tubular network formation [GO:0071787]; endoplasmic reticulum tubular network organization [GO:0071786]; negative regulation of amyloid-beta formation [GO:1902430]; neuron differentiation [GO:0030182]; vesicle-mediated transport [GO:0016192] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] | 49305.62393267875 | -0.414818054625697 | 0.128036729655354 | 0.344962487031496 | |
| Q8NCA5 | Q8NCA5 | FA98A_HUMAN | Protein FAM98A | FAM98A | lysosome localization [GO:0032418]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of ruffle assembly [GO:1900029]; protein methylation [GO:0006479]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388] | cytoplasm [GO:0005737]; nucleus [GO:0005634]; tRNA-splicing ligase complex [GO:0072669] | protein methyltransferase activity [GO:0008276]; RNA binding [GO:0003723] | 71409.26327111534 | -0.109570315414747 | 0.128355687683057 | 0.345493266704133 |
| P36542 | P36542 | ATPG_HUMAN | ATP synthase subunit gamma, mitochondrial (ATP synthase F1 subunit gamma) (F-ATPase gamma subunit) | ATP5F1C | ATP biosynthetic process [GO:0006754]; oxidative phosphorylation [GO:0006119]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776] | membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) [GO:0000275]; mitochondrion [GO:0005739] | proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; RNA binding [GO:0003723] | 89128.32334346476 | 0.123983347500874 | 0.129047226658016 | 0.347131596452201 |
| A5PLL7 | A5PLL7 | PDES1_HUMAN | Plasmanylethanolamine desaturase 1 (EC 1.14.19.77) (Transmembrane protein 189) | PEDS1 | ether lipid biosynthetic process [GO:0008611]; fatty acid metabolic process [GO:0006631] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] | plasmanylethanolamine desaturase activity [GO:0050207] | 31207.98987629775 | 0.210251820256033 | 0.129088878411627 | 0.347131596452201 |
| P61081 | P61081 | UBC12_HUMAN | NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.34) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M) | UBE2M | positive regulation of neuron apoptotic process [GO:0043525]; post-translational protein modification [GO:0043687]; protein modification process [GO:0036211]; protein neddylation [GO:0045116] | cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | ATP binding [GO:0005524]; NEDD8 conjugating enzyme activity [GO:0061654]; NEDD8 transferase activity [GO:0019788]; ubiquitin-protein transferase activity [GO:0004842] | 90634.41276640575 | 0.203129805620856 | 0.129148147779957 | 0.347131596452201 |
| P08493 | P08493 | MGP_HUMAN | Matrix Gla protein (MGP) (Cell growth-inhibiting gene 36 protein) | MGP | cartilage condensation [GO:0001502]; cell differentiation [GO:0030154]; ossification [GO:0001503]; regulation of bone mineralization [GO:0030500] | collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012] | calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]; structural constituent of bone [GO:0008147] | 13517.6861023401 | -0.577899375417651 | 0.129215981531189 | 0.347149241989435 |
| Q4J6C6 | Q4J6C6 | PPCEL_HUMAN | Prolyl endopeptidase-like (EC 3.4.21.-) (Prolylendopeptidase-like) | PREPL | Golgi to plasma membrane protein transport [GO:0043001]; proteolysis [GO:0006508]; regulation of synaptic vesicle exocytosis [GO:2000300]; retrograde transport, endosome to Golgi [GO:0042147] | cytoskeleton [GO:0005856]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802] | peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252] | 6228.02054351686 | 0.454772171711393 | 0.130162543203272 | 0.3495265259667 |
| P10746 | P10746 | HEM4_HUMAN | Uroporphyrinogen-III synthase (UROIIIS) (UROS) (EC 4.2.1.75) (Hydroxymethylbilane hydrolyase [cyclizing]) (Uroporphyrinogen-III cosynthase) | UROS | cellular response to amine stimulus [GO:0071418]; cellular response to arsenic-containing substance [GO:0071243]; heme A biosynthetic process [GO:0006784]; heme B biosynthetic process [GO:0006785]; heme biosynthetic process [GO:0006783]; heme O biosynthetic process [GO:0048034]; protoporphyrinogen IX biosynthetic process [GO:0006782]; response to platinum ion [GO:0070541]; uroporphyrinogen III biosynthetic process [GO:0006780] | cytosol [GO:0005829]; mitochondrion [GO:0005739] | folic acid binding [GO:0005542]; uroporphyrinogen-III synthase activity [GO:0004852] | 10056.97432642399 | -0.363425132721408 | 0.13033446132462 | 0.349822386482851 |
| Q9BT09 | Q9BT09 | CNPY3_HUMAN | Protein canopy homolog 3 (CTG repeat protein 4a) (Expanded repeat-domain protein CAG/CTG 5) (Protein associated with TLR4) (Trinucleotide repeat-containing gene 5 protein) | CNPY3 | innate immune response [GO:0045087] | endoplasmic reticulum lumen [GO:0005788] | signaling receptor binding [GO:0005102] | 55933.7866942326 | 0.360644550469269 | 0.130953340898014 | 0.351317059435677 |
| P10253 | P10253 | LYAG_HUMAN | Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) (Aglucosidase alfa) [Cleaved into: 76 kDa lysosomal alpha-glucosidase; 70 kDa lysosomal alpha-glucosidase] | GAA | aorta development [GO:0035904]; cardiac muscle contraction [GO:0060048]; diaphragm contraction [GO:0002086]; glucose metabolic process [GO:0006006]; glycogen catabolic process [GO:0005980]; glycophagy [GO:0061723]; heart morphogenesis [GO:0003007]; locomotory behavior [GO:0007626]; lysosome organization [GO:0007040]; maltose metabolic process [GO:0000023]; muscle cell cellular homeostasis [GO:0046716]; neuromuscular process controlling balance [GO:0050885]; neuromuscular process controlling posture [GO:0050884]; regulation of the force of heart contraction [GO:0002026]; sucrose metabolic process [GO:0005985]; tissue development [GO:0009888]; vacuolar sequestering [GO:0043181] | autolysosome lumen [GO:0120282]; azurophil granule membrane [GO:0035577]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821] | alpha-1,4-glucosidase activity [GO:0004558]; alpha-glucosidase activity [GO:0090599]; carbohydrate binding [GO:0030246]; maltose alpha-glucosidase activity [GO:0032450] | 45951.20986613375 | 0.201865163600202 | 0.131402174966912 | 0.352354341392581 |
| Q8TAD7 | Q8TAD7 | OCC1_HUMAN | Overexpressed in colon carcinoma 1 protein (OCC-1) (AGD3) | OCC1 | 41644.2621516811 | -0.363020148383167 | 0.131531334774078 | 0.352533842398263 | |||
| Q9NZT2 | Q9NZT2 | OGFR_HUMAN | Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) | OGFR | regulation of cell growth [GO:0001558] | cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] | opioid growth factor receptor activity [GO:0140625] | 10588.93720928215 | 0.166989805537101 | 0.131875044388143 | 0.353120983697173 |
| Q8NHP8 | Q8NHP8 | PLBL2_HUMAN | Putative phospholipase B-like 2 (EC 3.1.1.-) (76 kDa protein) (p76) (LAMA-like protein 2) (Lamina ancestor homolog 2) (Phospholipase B domain-containing protein 2) [Cleaved into: Putative phospholipase B-like 2 32 kDa form; Putative phospholipase B-like 2 45 kDa form] | PLBD2 | phospholipid catabolic process [GO:0009395] | extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202] | phospholipase activity [GO:0004620] | 37053.50409909045 | 0.255233240156603 | 0.131983202382273 | 0.353243658336306 |
| P06241 | P06241 | FYN_HUMAN | Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) | FYN | activated T cell proliferation [GO:0050798]; adaptive immune response [GO:0002250]; axon guidance [GO:0007411]; calcium ion transport [GO:0006816]; cell differentiation [GO:0030154]; cellular response to amyloid-beta [GO:1904646]; cellular response to glycine [GO:1905430]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to L-glutamate [GO:1905232]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to transforming growth factor beta stimulus [GO:0071560]; dendrite morphogenesis [GO:0048813]; dendritic spine maintenance [GO:0097062]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; ephrin receptor signaling pathway [GO:0048013]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; feeding behavior [GO:0007631]; forebrain development [GO:0030900]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; gene expression [GO:0010467]; heart process [GO:0003015]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; learning [GO:0007612]; leukocyte migration [GO:0050900]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of dendritic spine maintenance [GO:1902951]; negative regulation of gene expression [GO:0010629]; negative regulation of hydrogen peroxide biosynthetic process [GO:0010730]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein ubiquitination [GO:0031397]; neuron migration [GO:0001764]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein catabolic process [GO:0030163]; protein phosphorylation [GO:0006468]; protein ubiquitination [GO:0016567]; regulation of calcium ion import across plasma membrane [GO:1905664]; regulation of cell shape [GO:0008360]; regulation of glutamate receptor signaling pathway [GO:1900449]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; response to amyloid-beta [GO:1904645]; response to ethanol [GO:0045471]; response to singlet oxygen [GO:0000304]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell costimulation [GO:0031295]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] | actin filament [GO:0005884]; cell body [GO:0044297]; cytosol [GO:0005829]; dendrite [GO:0030425]; endosome [GO:0005768]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; glial cell projection [GO:0097386]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear endoplasmic reticulum [GO:0097038]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; Schaffer collateral - CA1 synapse [GO:0098685] | alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; disordered domain specific binding [GO:0097718]; enzyme binding [GO:0019899]; ephrin receptor binding [GO:0046875]; growth factor receptor binding [GO:0070851]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; protein tyrosine kinase activity [GO:0004713]; scaffold protein binding [GO:0097110]; signaling receptor binding [GO:0005102]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; transmembrane transporter binding [GO:0044325]; type 5 metabotropic glutamate receptor binding [GO:0031802] | 9312.858197742295 | -0.366795681061512 | 0.13211958056473 | 0.353290526947182 |
| Q14739 | Q14739 | LBR_HUMAN | Delta(14)-sterol reductase LBR (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase) | LBR | cholesterol biosynthetic process [GO:0006695]; ergosterol biosynthetic process [GO:0006696]; neutrophil differentiation [GO:0030223] | cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; nucleus [GO:0005634] | chromo shadow domain binding [GO:0070087]; delta14-sterol reductase activity [GO:0050613]; DNA binding [GO:0003677]; lamin binding [GO:0005521]; NADPH binding [GO:0070402]; RNA binding [GO:0003723] | 12515.2152272237 | 0.203097318766472 | 0.132125419449537 | 0.353290526947182 |
| Q6NXT4 | Q6NXT4 | ZNT6_HUMAN | Zinc transporter 6 (ZnT-6) (Solute carrier family 30 member 6) | SLC30A6 | regulation of zinc ion transport [GO:0071579]; zinc ion import into Golgi lumen [GO:1904257]; zinc ion transport [GO:0006829] | Golgi apparatus [GO:0005794]; trans-Golgi network membrane [GO:0032588] | antiporter activity [GO:0015297]; zinc ion transmembrane transporter activity [GO:0005385] | 10772.90103589883 | -0.532921325593669 | 0.132218207049627 | 0.353371868463766 |
| Q13976 | Q13976 | KGP1_HUMAN | cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI) | PRKG1 | actin cytoskeleton organization [GO:0030036]; cell growth involved in cardiac muscle cell development [GO:0061049]; cerebellum development [GO:0021549]; cGMP-mediated signaling [GO:0019934]; collateral sprouting [GO:0048668]; dendrite development [GO:0016358]; forebrain development [GO:0030900]; negative regulation of glutamate secretion [GO:0014050]; negative regulation of inositol phosphate biosynthetic process [GO:0010920]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; neuron migration [GO:0001764]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; protein phosphorylation [GO:0006468]; regulation of GTPase activity [GO:0043087]; regulation of testosterone biosynthetic process [GO:2000224]; relaxation of vascular associated smooth muscle [GO:0060087]; signal transduction [GO:0007165]; spermatid development [GO:0007286] | acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383] | ATP binding [GO:0005524]; calcium channel regulator activity [GO:0005246]; cGMP binding [GO:0030553]; cGMP-dependent protein kinase activity [GO:0004692]; identical protein binding [GO:0042802]; mitogen-activated protein kinase p38 binding [GO:0048273]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310] | 9947.710838742445 | -0.176119815577251 | 0.132354211280214 | 0.353568581383164 |
| P15529 | P15529 | MCP_HUMAN | Membrane cofactor protein (TLX) (Trophoblast leukocyte common antigen) (CD antigen CD46) | CD46 | adaptive immune response [GO:0002250]; complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; negative regulation of complement activation, classical pathway [GO:0045959]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transforming growth factor beta production [GO:0071636]; regulation of Notch signaling pathway [GO:0008593]; sequestering of extracellular ligand from receptor [GO:0035581]; single fertilization [GO:0007338]; T cell mediated immunity [GO:0002456] | cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; inner acrosomal membrane [GO:0002079]; plasma membrane [GO:0005886] | cadherin binding [GO:0045296]; signaling receptor activity [GO:0038023]; virus receptor activity [GO:0001618] | 40717.260041827845 | 0.190459346032421 | 0.132499537148562 | 0.353711530812161 |
| Q96EM0 | Q96EM0 | T3HPD_HUMAN | Trans-3-hydroxy-L-proline dehydratase (EC 4.2.1.77) (Trans-L-3-hydroxyproline dehydratase) | L3HYPDH | 4-hydroxyproline epimerase activity [GO:0047580]; hydro-lyase activity [GO:0016836]; trans-L-3-hydroxyproline dehydratase activity [GO:0050346] | 8387.55397131696 | -0.312388395882396 | 0.132595003784862 | 0.353711530812161 | ||
| P12694 | P12694 | ODBA_HUMAN | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) (BCKDE1A) (BCKDH E1-alpha) | BCKDHA | branched-chain amino acid catabolic process [GO:0009083] | mitochondrial branched-chain alpha-keto acid dehydrogenase complex [GO:0160120]; mitochondrial matrix [GO:0005759]; mitochondrial oxoglutarate dehydrogenase complex [GO:0009353]; mitochondrion [GO:0005739] | 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity [GO:0003863]; carboxy-lyase activity [GO:0016831]; metal ion binding [GO:0046872] | 7244.233330504056 | 0.178858397445793 | 0.133010801133565 | 0.35398741156542 |
| Q96A33 | Q96A33 | CCD47_HUMAN | PAT complex subunit CCDC47 (Calumin) (Coiled-coil domain-containing protein 47) | CCDC47 | endoplasmic reticulum calcium ion homeostasis [GO:0032469]; ER overload response [GO:0006983]; ERAD pathway [GO:0036503]; multi-pass transmembrane protein insertion into ER membrane [GO:0160063]; osteoblast differentiation [GO:0001649]; post-embryonic development [GO:0009791]; protein insertion into ER membrane [GO:0045048] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; multi-pass translocon complex [GO:0160064]; protein folding chaperone complex [GO:0101031]; rough endoplasmic reticulum membrane [GO:0030867] | calcium ion binding [GO:0005509]; protein folding chaperone [GO:0044183]; ribosome binding [GO:0043022]; RNA binding [GO:0003723] | 56636.976313144696 | 0.192655830837292 | 0.132911203040661 | 0.35398741156542 |
| Q99755 | Q99755 | PI51A_HUMAN | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha) | PIP5K1A | actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; fibroblast migration [GO:0010761]; focal adhesion assembly [GO:0048041]; glycerophospholipid metabolic process [GO:0006650]; keratinocyte differentiation [GO:0030216]; phagocytosis [GO:0006909]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phospholipid biosynthetic process [GO:0008654]; phosphorylation [GO:0016310]; protein localization to plasma membrane [GO:0072659]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; ruffle assembly [GO:0097178]; signal transduction [GO:0007165] | cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] | 1-phosphatidylinositol-3-phosphate 5-kinase activity [GO:0000285]; 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-kinase activity [GO:0052810]; ATP binding [GO:0005524]; kinase binding [GO:0019900]; phosphatidylinositol kinase activity [GO:0052742] | 7371.43263930334 | -0.253312062406265 | 0.132910952922363 | 0.35398741156542 |
| P26373 | P26373 | RL13_HUMAN | Large ribosomal subunit protein eL13 (60S ribosomal protein L13) (Breast basic conserved protein 1) | RPL13 | blastocyst development [GO:0001824]; bone development [GO:0060348]; cytoplasmic translation [GO:0002181]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; synapse [GO:0045202] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 330441.9622987415 | 0.207038917987783 | 0.133000337230314 | 0.35398741156542 |
| P62277 | P62277 | RS13_HUMAN | Small ribosomal subunit protein uS15 (40S ribosomal protein S13) | RPS13 | cytoplasmic translation [GO:0002181]; negative regulation of RNA splicing [GO:0033119]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribosome [GO:0005840]; small-subunit processome [GO:0032040] | mRNA 5'-UTR binding [GO:0048027]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735] | 107355.71509186551 | 0.280453392450612 | 0.132806111184475 | 0.35398741156542 |
| O00478;O00481;P78410 | O00478 | BT3A3_HUMAN | Butyrophilin subfamily 3 member A3 | BTN3A3 | regulation of cytokine production [GO:0001817]; T cell mediated immunity [GO:0002456]; T cell receptor signaling pathway [GO:0050852] | external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886] | signaling receptor binding [GO:0005102] | 32940.73025710855 | 1.03765803310942 | 0.13427399471626 | 0.357181433832079 |
| Q9Y6B7 | Q9Y6B7 | AP4B1_HUMAN | AP-4 complex subunit beta-1 (AP-4 adaptor complex subunit beta) (Adaptor-related protein complex 4 subunit beta-1) (Beta subunit of AP-4) (Beta4-adaptin) | AP4B1 | intracellular protein transport [GO:0006886]; protein localization [GO:0008104]; protein localization to somatodendritic compartment [GO:0061938]; protein targeting [GO:0006605]; vesicle-mediated transport [GO:0016192] | AP-4 adaptor complex [GO:0030124]; clathrin adaptor complex [GO:0030131]; cytoplasmic side of trans-Golgi network transport vesicle membrane [GO:0098541]; cytosol [GO:0005829]; endosome lumen [GO:0031904]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588] | clathrin binding [GO:0030276] | 1582.99757999625 | -0.302198493942442 | 0.135146291072908 | 0.359164580309145 |
| Q9UBS4 | Q9UBS4 | DJB11_HUMAN | DnaJ homolog subfamily B member 11 (APOBEC1-binding protein 2) (ABBP-2) (DnaJ protein homolog 9) (ER-associated DNAJ) (ER-associated Hsp40 co-chaperone) (Endoplasmic reticulum DNA J domain-containing protein 3) (ER-resident protein ERdj3) (ERdj3) (ERj3p) (HEDJ) (Human DnaJ protein 9) (hDj-9) (PWP1-interacting protein 4) | DNAJB11 | mRNA modification [GO:0016556]; negative regulation of neurogenesis [GO:0050768]; positive regulation of ATP-dependent activity [GO:0032781]; protein folding [GO:0006457]; protein maturation [GO:0051604] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031] | misfolded protein binding [GO:0051787]; signaling receptor binding [GO:0005102]; unfolded protein binding [GO:0051082] | 119168.314198696 | 0.286762415710059 | 0.136013465935662 | 0.361264263031861 |
| Q16595 | Q16595 | FRDA_HUMAN | Frataxin, mitochondrial (EC 1.16.3.1) (Friedreich ataxia protein) (Fxn) [Cleaved into: Frataxin intermediate form (i-FXN); Frataxin(56-210) (m56-FXN); Frataxin(78-210) (d-FXN) (m78-FXN); Frataxin mature form (Frataxin(81-210)) (m81-FXN); Extramitochondrial frataxin] | FXN | [2Fe-2S] cluster assembly [GO:0044571]; [4Fe-4S] cluster assembly [GO:0044572]; adult walking behavior [GO:0007628]; cellular response to hydrogen peroxide [GO:0070301]; embryo development ending in birth or egg hatching [GO:0009792]; heme biosynthetic process [GO:0006783]; intracellular iron ion homeostasis [GO:0006879]; iron incorporation into metallo-sulfur cluster [GO:0018283]; iron ion transport [GO:0006826]; iron-sulfur cluster assembly [GO:0016226]; mitochondrion organization [GO:0007005]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of apoptotic process [GO:0043066]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of organ growth [GO:0046621]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; organ growth [GO:0035265]; oxidative phosphorylation [GO:0006119]; positive regulation of aconitate hydratase activity [GO:1904234]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of lyase activity [GO:0051349]; positive regulation of succinate dehydrogenase activity [GO:1904231]; proprioception [GO:0019230]; protein autoprocessing [GO:0016540]; regulation of ferrochelatase activity [GO:0010722]; response to iron ion [GO:0010039] | cytosol [GO:0005829]; iron-sulfur cluster assembly complex [GO:1990229]; L-cysteine desulfurase complex [GO:1990221]; mitochondrial iron-sulfur cluster assembly complex [GO:0099128]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739] | 2 iron, 2 sulfur cluster binding [GO:0051537]; ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; ferroxidase activity [GO:0004322]; iron chaperone activity [GO:0034986] | 28849.791038932548 | 0.26412055381639 | 0.136063878805152 | 0.361264263031861 |
| Q92633 | Q92633 | LPAR1_HUMAN | Lysophosphatidic acid receptor 1 (LPA receptor 1) (LPA-1) (Lysophosphatidic acid receptor Edg-2) | LPAR1 | activation of phospholipase C activity [GO:0007202]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; bleb assembly [GO:0032060]; calmodulin dependent kinase signaling pathway [GO:0099004]; cell chemotaxis [GO:0060326]; cellular response to 1-oleoyl-sn-glycerol 3-phosphate [GO:1904566]; cellular response to oxygen levels [GO:0071453]; cerebellum development [GO:0021549]; corpus callosum development [GO:0022038]; G protein-coupled receptor signaling pathway [GO:0007186]; myelination [GO:0042552]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of cilium assembly [GO:1902018]; negative regulation of neuron projection development [GO:0010977]; neurogenesis [GO:0022008]; oligodendrocyte development [GO:0014003]; optic nerve development [GO:0021554]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of smooth muscle cell chemotaxis [GO:0071673]; positive regulation of stress fiber assembly [GO:0051496]; regulation of cell shape [GO:0008360]; regulation of metabolic process [GO:0019222]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation of synaptic vesicle cycle [GO:0098693] | cell surface [GO:0009986]; cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; endosome [GO:0005768]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734] | G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; lysophosphatidic acid binding [GO:0035727]; lysophosphatidic acid receptor activity [GO:0070915]; PDZ domain binding [GO:0030165] | 13648.92298131735 | 0.302978980878784 | 0.136246200119071 | 0.361578908606398 |
| P52926 | P52926 | HMGA2_HUMAN | High mobility group protein HMGI-C (High mobility group AT-hook protein 2) | HMGA2 | base-excision repair [GO:0006284]; cell cycle [GO:0007049]; cell division [GO:0051301]; chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; chromatin organization [GO:0006325]; chromosome condensation [GO:0030261]; endodermal cell differentiation [GO:0035987]; epithelial to mesenchymal transition [GO:0001837]; fat cell differentiation [GO:0045444]; heterochromatin formation [GO:0031507]; intracellular signal transduction [GO:0035556]; mesenchymal cell differentiation [GO:0048762]; mesodermal cell differentiation [GO:0048333]; mesodermal-endodermal cell signaling [GO:0003131]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oncogene-induced cell senescence [GO:0090402]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell proliferation in bone marrow [GO:0071864]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle process [GO:0010564]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell population maintenance [GO:2000036]; response to virus [GO:0009615]; stem cell differentiation [GO:0048863] | nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; senescence-associated heterochromatin focus [GO:0035985]; SMAD protein complex [GO:0071141] | 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; C2H2 zinc finger domain binding [GO:0070742]; cAMP response element binding [GO:0035497]; DNA binding, bending [GO:0008301]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; MH1 domain binding [GO:0035501]; MH2 domain binding [GO:0035500]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; nucleic acid binding [GO:0003676]; nucleosomal DNA binding [GO:0031492]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SMAD binding [GO:0046332]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714] | 27309.3171700386 | 0.403810774776277 | 0.136438414984938 | 0.361919503419784 |
| O14657 | O14657 | TOR1B_HUMAN | Torsin-1B (Torsin ATPase-1B) (EC 3.6.4.-) (Torsin family 1 member B) | TOR1B | chaperone cofactor-dependent protein refolding [GO:0051085]; endoplasmic reticulum organization [GO:0007029]; nuclear membrane organization [GO:0071763]; protein localization to nucleus [GO:0034504]; response to unfolded protein [GO:0006986] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894] | 11702.059105260349 | 0.315856732408791 | 0.136856070225864 | 0.362857507674191 |
| P06576 | P06576 | ATPB_HUMAN | ATP synthase subunit beta, mitochondrial (EC 7.1.2.2) (ATP synthase F1 subunit beta) | ATP5F1B | angiogenesis [GO:0001525]; ATP biosynthetic process [GO:0006754]; cellular response to interleukin-7 [GO:0098761]; generation of precursor metabolites and energy [GO:0006091]; lipid metabolic process [GO:0006629]; negative regulation of cell adhesion involved in substrate-bound cell migration [GO:0006933]; osteoblast differentiation [GO:0001649]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; proton transmembrane transport [GO:1902600]; regulation of intracellular pH [GO:0051453] | cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial nucleoid [GO:0042645]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase, catalytic core [GO:0005754]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex [GO:0045259]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261] | angiostatin binding [GO:0043532]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; MHC class I protein binding [GO:0042288]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton-transporting ATPase activity, rotational mechanism [GO:0046961] | 314590.3710857575 | 0.201111090193948 | 0.137408051468709 | 0.36398037382969 |
| P36551 | P36551 | HEM6_HUMAN | Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (COX) (Coprogen oxidase) (Coproporphyrinogenase) (EC 1.3.3.3) | CPOX | heme A biosynthetic process [GO:0006784]; heme B biosynthetic process [GO:0006785]; heme biosynthetic process [GO:0006783]; heme O biosynthetic process [GO:0048034]; protoporphyrinogen IX biosynthetic process [GO:0006782] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739] | coproporphyrinogen oxidase activity [GO:0004109]; protein homodimerization activity [GO:0042803]; structural constituent of eye lens [GO:0005212] | 22496.42980597155 | 0.0690444449231213 | 0.137734210139703 | 0.36424030425099 |
| Q9Y6M7 | Q9Y6M7 | S4A7_HUMAN | Sodium bicarbonate cotransporter 3 (Electroneutral Na/HCO(3) cotransporter) (Sodium bicarbonate cotransporter 2) (Sodium bicarbonate cotransporter 2b) (Bicarbonate transporter) (Solute carrier family 4 member 7) | SLC4A7 | auditory receptor cell development [GO:0060117]; bicarbonate transport [GO:0015701]; cellular response to growth factor stimulus [GO:0071363]; phagosome acidification [GO:0090383]; purine nucleotide biosynthetic process [GO:0006164]; pyrimidine nucleotide biosynthetic process [GO:0006221]; regulation of intracellular pH [GO:0051453]; transmembrane transport [GO:0055085] | apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; stereocilium [GO:0032420] | monoatomic anion transmembrane transporter activity [GO:0008509]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452] | 6508.00087006396 | 0.198258142247639 | 0.137763320157055 | 0.36424030425099 |
| Q8TCT8 | Q8TCT8 | SPP2A_HUMAN | Signal peptide peptidase-like 2A (SPP-like 2A) (SPPL2a) (EC 3.4.23.-) (Intramembrane protease 3) (IMP-3) (Presenilin-like protein 2) | SPPL2A | membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; membrane protein proteolysis [GO:0033619]; regulation of immune response [GO:0050776]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803] | cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; extracellular exosome [GO:0070062]; Golgi-associated vesicle membrane [GO:0030660]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886] | aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; protein homodimerization activity [GO:0042803] | 18057.72716728735 | 0.306401806770063 | 0.137689844789642 | 0.36424030425099 |
| Q8IWB9 | Q8IWB9 | TEX2_HUMAN | Testis-expressed protein 2 (Transmembrane protein 96) | TEX2 | lipid transport [GO:0006869]; signal transduction [GO:0007165]; sphingolipid metabolic process [GO:0006665] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965] | lipid binding [GO:0008289] | 2814.994320704725 | -1.04146188820829 | 0.137730724866967 | 0.36424030425099 |
| Q9BZL1 | Q9BZL1 | UBL5_HUMAN | Ubiquitin-like protein 5 | UBL5 | mRNA splicing, via spliceosome [GO:0000398]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein modification process [GO:0036211] | Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | protein tag activity [GO:0031386] | 43590.0144237701 | 0.308120054852387 | 0.137996396067786 | 0.364686371324662 |
| Q01658 | Q01658 | NC2B_HUMAN | Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein) | DR1 | negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]; RNA polymerase II preinitiation complex assembly [GO:0051123] | ATAC complex [GO:0140672]; mitotic spindle [GO:0072686]; negative cofactor 2 complex [GO:0017054]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575] | DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; TBP-class protein binding [GO:0017025] | 17884.0755194316 | 0.367698813991794 | 0.13858068514985 | 0.365889171509343 |
| Q9H0E2 | Q9H0E2 | TOLIP_HUMAN | Toll-interacting protein | TOLLIP | autophagy [GO:0006914]; epithelial cell differentiation [GO:0030855]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; leukocyte activation [GO:0045321]; phosphorylation [GO:0016310]; positive regulation of protein sumoylation [GO:0033235]; protein localization to endosome [GO:0036010]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511] | azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extrinsic component of plasma membrane [GO:0019897]; nuclear body [GO:0016604]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; specific granule lumen [GO:0035580] | interleukin-1, type I receptor binding [GO:0005150]; kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; SUMO binding [GO:0032183]; Toll-like receptor binding [GO:0035325]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase binding [GO:0031625] | 27317.6587856203 | -0.135598231658259 | 0.138519648694527 | 0.365889171509343 |
| Q13443 | Q13443 | ADAM9_HUMAN | Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (EC 3.4.24.-) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) | ADAM9 | amyloid precursor protein catabolic process [GO:0042987]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell-cell adhesion mediated by integrin [GO:0033631]; cell-matrix adhesion [GO:0007160]; cellular response to lipopolysaccharide [GO:0071222]; integrin-mediated signaling pathway [GO:0007229]; keratinocyte differentiation [GO:0030216]; membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; monocyte activation [GO:0042117]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell migration [GO:0030335]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of macrophage fusion [GO:0034241]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of protein secretion [GO:0050714]; protein processing [GO:0016485]; response to antineoplastic agent [GO:0097327]; response to calcium ion [GO:0051592]; response to glucocorticoid [GO:0051384]; response to hydrogen peroxide [GO:0042542]; response to laminar fluid shear stress [GO:0034616]; response to manganese ion [GO:0010042]; response to tumor necrosis factor [GO:0034612]; transforming growth factor beta receptor signaling pathway [GO:0007179] | basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886] | collagen binding [GO:0005518]; integrin binding [GO:0005178]; laminin binding [GO:0043236]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902945]; metallopeptidase activity [GO:0008237]; protein kinase C binding [GO:0005080]; SH3 domain binding [GO:0017124] | 17238.77779577855 | 0.199288847567771 | 0.138699587238659 | 0.365902463881575 |
| Q9Y5A7 | Q9Y5A7 | NUB1_HUMAN | NEDD8 ultimate buster 1 (Negative regulator of ubiquitin-like proteins 1) (Renal carcinoma antigen NY-REN-18) | NUB1 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; regulation of ubiquitin-dependent protein catabolic process [GO:2000058]; response to tumor necrosis factor [GO:0034612]; response to type II interferon [GO:0034341]; ubiquitin-dependent protein catabolic process [GO:0006511] | cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] | 8623.30739715917 | 0.150695869417036 | 0.138986070989938 | 0.366284379426187 | |
| P62829 | P62829 | RL23_HUMAN | Large ribosomal subunit protein uL14 (60S ribosomal protein L17) (60S ribosomal protein L23) | RPL23 | cellular response to actinomycin D [GO:0072717]; cytoplasmic translation [GO:0002181]; G1 to G0 transition [GO:0070314]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; protein stabilization [GO:0050821]; protein-DNA complex disassembly [GO:0032986]; regulation of G1 to G0 transition [GO:1903450]; ribosomal protein import into nucleus [GO:0006610]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; ribosome [GO:0005840]; synapse [GO:0045202] | large ribosomal subunit rRNA binding [GO:0070180]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; transcription coactivator binding [GO:0001223]; ubiquitin ligase inhibitor activity [GO:1990948]; ubiquitin protein ligase binding [GO:0031625] | 324259.60979040095 | 0.194182277879362 | 0.138988954423986 | 0.366284379426187 |
| A4D1P6 | A4D1P6 | WDR91_HUMAN | WD repeat-containing protein 91 | WDR91 | early endosome to late endosome transport [GO:0045022]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; regulation of protein catabolic process [GO:0042176] | cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; extrinsic component of endosome membrane [GO:0031313]; late endosome membrane [GO:0031902] | phosphatidylinositol 3-kinase inhibitor activity [GO:0141039]; phosphatidylinositol 3-kinase regulator activity [GO:0035014] | 5311.59592618868 | -0.52195717958142 | 0.139131510591563 | 0.366489604375545 |
| Q9Y399 | Q9Y399 | RT02_HUMAN | Small ribosomal subunit protein uS2m (28S ribosomal protein S2, mitochondrial) (MRP-S2) (S2mt) | MRPS2 | mitochondrial ribosome assembly [GO:0061668]; mitochondrial translation [GO:0032543] | cytosolic small ribosomal subunit [GO:0022627]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739] | structural constituent of ribosome [GO:0003735] | 8427.80453750139 | 0.356148543088914 | 0.139447459317438 | 0.367151163797678 |
| Q96K19 | Q96K19 | RN170_HUMAN | E3 ubiquitin-protein ligase RNF170 (EC 2.3.2.27) (Putative LAG1-interacting protein) (RING finger protein 170) (RING-type E3 ubiquitin transferase RNF170) | RNF170 | negative regulation of toll-like receptor 3 signaling pathway [GO:0034140]; protein K48-linked ubiquitination [GO:0070936] | endoplasmic reticulum membrane [GO:0005789] | metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] | 22464.98350034485 | -2.38911183227741 | 0.139809981250284 | 0.367934674298239 |
| O95071 | O95071 | UBR5_HUMAN | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | UBR5 | DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; heterochromatin boundary formation [GO:0033696]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of gene expression [GO:0010628]; positive regulation of protein import into nucleus [GO:0042307]; progesterone receptor signaling pathway [GO:0050847]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991] | RNA binding [GO:0003723]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-ubiquitin ligase activity [GO:0034450]; zinc ion binding [GO:0008270] | 2100.73364031841 | -0.738351951693436 | 0.139888490143704 | 0.367970373794906 |
| Q8N183 | Q8N183 | NDUF2_HUMAN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 (B17.2-like) (B17.2L) (Mimitin) (Myc-induced mitochondrial protein) (MMTN) (NDUFA12-like protein) | NDUFAF2 | mitochondrial respiratory chain complex I assembly [GO:0032981]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179] | mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] | protein-containing complex binding [GO:0044877] | 35624.9497881385 | 0.446674793750974 | 0.139955906908362 | 0.367976876353958 |
| O94906 | O94906 | PRP6_HUMAN | Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein) | PRPF6 | mRNA splicing, via spliceosome [GO:0000398]; positive regulation of miRNA metabolic process [GO:2000630]; positive regulation of primary miRNA processing [GO:2000636]; positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA localization [GO:0006403]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal complex assembly [GO:0000245]; spliceosomal tri-snRNP complex assembly [GO:0000244] | catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682] | identical protein binding [GO:0042802]; protein-macromolecule adaptor activity [GO:0030674]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723] | 11933.988994183801 | -0.197804087687096 | 0.140668370430615 | 0.369507179814493 |
| Q6P4Q7 | Q6P4Q7 | CNNM4_HUMAN | Metal transporter CNNM4 (Ancient conserved domain-containing protein 4) (Cyclin-M4) | CNNM4 | enamel mineralization [GO:0070166]; intracellular manganese ion homeostasis [GO:0030026]; intracellular monoatomic cation homeostasis [GO:0030003]; magnesium ion homeostasis [GO:0010960]; magnesium ion transport [GO:0015693]; response to stimulus [GO:0050896]; visual perception [GO:0007601] | basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] | magnesium ion transmembrane transporter activity [GO:0015095]; sodium ion transmembrane transporter activity [GO:0015081] | 3477.932592111415 | -0.479471419884718 | 0.140754146881759 | 0.369561166001874 |
| P52895 | P52895 | AK1C2_HUMAN | Aldo-keto reductase family 1 member C2 (EC 1.-.-.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (3-alpha-HSD3) (Chlordecone reductase homolog HAKRD) (Dihydrodiol dehydrogenase 2) (DD-2) (DD2) (Dihydrodiol dehydrogenase/bile acid-binding protein) (DD/BABP) (Type III 3-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.357) | AKR1C2 | cellular response to jasmonic acid stimulus [GO:0071395]; cellular response to prostaglandin D stimulus [GO:0071799]; daunorubicin metabolic process [GO:0044597]; digestion [GO:0007586]; doxorubicin metabolic process [GO:0044598]; epithelial cell differentiation [GO:0030855]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; progesterone metabolic process [GO:0042448]; prostaglandin metabolic process [GO:0006693]; steroid metabolic process [GO:0008202] | cytosol [GO:0005829] | alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]; bile acid binding [GO:0032052]; carboxylic acid binding [GO:0031406]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; indanol dehydrogenase activity [GO:0047718]; ketosteroid monooxygenase activity [GO:0047086]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; phenanthrene 9,10-monooxygenase activity [GO:0018636]; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity [GO:0047115] | 18734.3489559803 | 0.183728780475013 | 0.141036087332508 | 0.370129907747101 |
| Q00534 | Q00534 | CDK6_HUMAN | Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE) | CDK6 | astrocyte development [GO:0014002]; cell dedifferentiation [GO:0043697]; cell division [GO:0051301]; dentate gyrus development [GO:0021542]; G1/S transition of mitotic cell cycle [GO:0000082]; generation of neurons [GO:0048699]; gliogenesis [GO:0042063]; hematopoietic stem cell differentiation [GO:0060218]; lateral ventricle development [GO:0021670]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cellular senescence [GO:2000773]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of monocyte differentiation [GO:0045656]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of cell motility [GO:2000145]; regulation of erythrocyte differentiation [GO:0045646]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of gene expression [GO:0010468]; regulation of hematopoietic stem cell differentiation [GO:1902036]; response to organic substance [GO:0010033]; response to virus [GO:0009615]; signal transduction [GO:0007165]; T cell differentiation in thymus [GO:0033077]; type B pancreatic cell development [GO:0003323] | centrosome [GO:0005813]; cyclin D2-CDK6 complex [GO:0097132]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ruffle [GO:0001726] | ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; FBXO family protein binding [GO:0098770]; protein serine kinase activity [GO:0106310] | 15585.693671742101 | 0.284880157208989 | 0.141182576315323 | 0.370212629698193 |
| Q9H6L2 | Q9H6L2 | TM231_HUMAN | Transmembrane protein 231 | TMEM231 | camera-type eye development [GO:0043010]; cilium assembly [GO:0060271]; embryonic digit morphogenesis [GO:0042733]; in utero embryonic development [GO:0001701]; neuroepithelial cell differentiation [GO:0060563]; regulation of protein localization [GO:0032880]; smoothened signaling pathway [GO:0007224]; vasculature development [GO:0001944] | ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; MKS complex [GO:0036038] | 27318.4453183617 | -0.237755431470653 | 0.141263626086744 | 0.370212629698193 | |
| Q99816 | Q99816 | TS101_HUMAN | Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) | TSG101 | autophagosome maturation [GO:0097352]; cell cycle [GO:0007049]; cell division [GO:0051301]; endosome to lysosome transport [GO:0008333]; exosomal secretion [GO:1990182]; extracellular transport [GO:0006858]; keratinocyte differentiation [GO:0030216]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of ubiquitin-dependent endocytosis [GO:2000397]; positive regulation of viral budding via host ESCRT complex [GO:1903774]; protein modification process [GO:0036211]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of extracellular exosome assembly [GO:1903551]; regulation of MAP kinase activity [GO:0043405]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding [GO:0046755]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076] | centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; multivesicular body [GO:0005771]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] | calcium-dependent protein binding [GO:0048306]; DNA binding [GO:0003677]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; transcription corepressor activity [GO:0003714]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; virion binding [GO:0046790] | 36187.258916815 | 0.147089039580723 | 0.141214065568124 | 0.370212629698193 |
| P17174 | P17174 | AATC_HUMAN | Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A) | GOT1 | 2-oxoglutarate metabolic process [GO:0006103]; aspartate biosynthetic process [GO:0006532]; aspartate catabolic process [GO:0006533]; aspartate metabolic process [GO:0006531]; cellular response to insulin stimulus [GO:0032869]; fatty acid homeostasis [GO:0055089]; gluconeogenesis [GO:0006094]; glutamate catabolic process to 2-oxoglutarate [GO:0019551]; glutamate catabolic process to aspartate [GO:0019550]; glutamate metabolic process [GO:0006536]; glycerol biosynthetic process [GO:0006114]; Notch signaling pathway [GO:0007219]; oxaloacetate metabolic process [GO:0006107]; response to glucocorticoid [GO:0051384] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634] | L-aspartate:2-oxoglutarate aminotransferase activity [GO:0004069]; L-cysteine transaminase activity [GO:0047801]; phosphatidylserine decarboxylase activity [GO:0004609]; pyridoxal phosphate binding [GO:0030170] | 86751.05928650929 | -0.0753919699055139 | 0.141449701886574 | 0.370528900087531 |
| P62942 | P62942 | FKB1A_HUMAN | Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase) | FKBP1A | 'de novo' protein folding [GO:0006458]; amyloid fibril formation [GO:1990000]; calcium ion transmembrane transport [GO:0070588]; heart morphogenesis [GO:0003007]; heart trabecula formation [GO:0060347]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein binding [GO:0032092]; protein folding [GO:0006457]; protein maturation by protein folding [GO:0022417]; protein peptidyl-prolyl isomerization [GO:0000413]; protein refolding [GO:0042026]; regulation of amyloid precursor protein catabolic process [GO:1902991]; regulation of immune response [GO:0050776]; regulation of protein localization [GO:0032880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; supramolecular fiber organization [GO:0097435]; T cell activation [GO:0042110]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] | cytoplasm [GO:0005737]; cytoplasmic side of membrane [GO:0098562]; cytosol [GO:0005829]; membrane [GO:0016020]; ryanodine receptor complex [GO:1990425]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; terminal cisterna [GO:0014802]; Z disc [GO:0030018] | activin receptor binding [GO:0070697]; FK506 binding [GO:0005528]; I-SMAD binding [GO:0070411]; macrolide binding [GO:0005527]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; signaling receptor inhibitor activity [GO:0030547]; transforming growth factor beta receptor binding [GO:0005160]; transmembrane transporter binding [GO:0044325]; type I transforming growth factor beta receptor binding [GO:0034713] | 355505.33436432853 | 0.296898122612155 | 0.141641036965455 | 0.370748645732819 |
| P83731 | P83731 | RL24_HUMAN | Large ribosomal subunit protein eL24 (60S ribosomal protein L24) (60S ribosomal protein L30) | RPL24 | cytoplasmic translation [GO:0002181]; exit from mitosis [GO:0010458]; optic nerve development [GO:0021554]; retina development in camera-type eye [GO:0060041]; retinal ganglion cell axon guidance [GO:0031290]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; synapse [GO:0045202] | cadherin binding [GO:0045296]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 354775.22795572353 | 0.222738971532823 | 0.141664457820606 | 0.370748645732819 |
| Q9HCM4 | Q9HCM4 | E41L5_HUMAN | Band 4.1-like protein 5 (Erythrocyte membrane protein band 4.1-like 5) | EPB41L5 | actomyosin structure organization [GO:0031032]; apical constriction [GO:0003383]; axial mesoderm morphogenesis [GO:0048319]; cellular response to transforming growth factor beta stimulus [GO:0071560]; ectoderm development [GO:0007398]; embryonic foregut morphogenesis [GO:0048617]; endoderm development [GO:0007492]; epithelial to mesenchymal transition [GO:0001837]; in utero embryonic development [GO:0001701]; left/right axis specification [GO:0070986]; mesoderm migration involved in gastrulation [GO:0007509]; negative regulation of cell-cell adhesion [GO:0022408]; neural plate morphogenesis [GO:0001839]; paraxial mesoderm development [GO:0048339]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of focal adhesion assembly [GO:0051894]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of establishment of protein localization [GO:0070201]; somite rostral/caudal axis specification [GO:0032525]; substrate-dependent cell migration, cell attachment to substrate [GO:0006931]; unidimensional cell growth [GO:0009826] | adherens junction [GO:0005912]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587] | cytoskeletal protein binding [GO:0008092]; protein domain specific binding [GO:0019904] | 4611.9580586475295 | 0.234605643237313 | 0.141816171809285 | 0.370832632389772 |
| P50914 | P50914 | RL14_HUMAN | Large ribosomal subunit protein eL14 (60S ribosomal protein L14) (CAG-ISL 7) | RPL14 | cytoplasmic translation [GO:0002181]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; translation [GO:0006412] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; postsynaptic density [GO:0014069] | cadherin binding [GO:0045296]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 399334.97915916704 | 0.214778279041708 | 0.141834360259394 | 0.370832632389772 |
| P12955 | P12955 | PEPD_HUMAN | Xaa-Pro dipeptidase (X-Pro dipeptidase) (EC 3.4.13.9) (Imidodipeptidase) (Peptidase D) (Proline dipeptidase) (Prolidase) | PEPD | amino acid metabolic process [GO:0006520]; collagen catabolic process [GO:0030574]; negative regulation of programmed cell death [GO:0043069]; proteolysis [GO:0006508] | extracellular exosome [GO:0070062] | manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; metallocarboxypeptidase activity [GO:0004181]; peptidase activity [GO:0008233]; proline dipeptidase activity [GO:0102009] | 24663.72789170595 | 0.185414118842646 | 0.142481314299367 | 0.371611513442653 |
| Q9UEU0 | Q9UEU0 | VTI1B_HUMAN | Vesicle transport through interaction with t-SNAREs homolog 1B (Vesicle transport v-SNARE protein Vti1-like 1) (Vti1-rp1) | VTI1B | Golgi to vacuole transport [GO:0006896]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; macroautophagy [GO:0016236]; membrane fusion [GO:0061025]; regulation of protein localization to plasma membrane [GO:1903076]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle docking involved in exocytosis [GO:0006904]; vesicle fusion with Golgi apparatus [GO:0048280]; vesicle-mediated transport [GO:0016192] | cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; platelet alpha granule lumen [GO:0031093]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; vesicle [GO:0031982] | chloride channel inhibitor activity [GO:0019869]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] | 56416.331473947605 | 0.25876366943 | 0.142518852578695 | 0.371611513442653 |
| Q9BXF6 | Q9BXF6 | RFIP5_HUMAN | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | RAB11FIP5 | cellular response to acidic pH [GO:0071468]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; negative regulation of adiponectin secretion [GO:0070164]; regulated exocytosis [GO:0045055]; regulation of protein localization to cell surface [GO:2000008] | centriolar satellite [GO:0034451]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; phagocytic vesicle [GO:0045335]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; secretory granule [GO:0030141]; transport vesicle membrane [GO:0030658] | gamma-tubulin binding [GO:0043015]; small GTPase binding [GO:0031267] | 26260.0811196866 | 0.129133869440209 | 0.143196473336724 | 0.373206631980625 |
| Q12788 | Q12788 | TBL3_HUMAN | Transducin beta-like protein 3 (WD repeat-containing protein SAZD) | TBL3 | endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; ribosomal small subunit biogenesis [GO:0042274] | 90S preribosome [GO:0030686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040] | RNA binding [GO:0003723]; U3 snoRNA binding [GO:0034511] | 4188.821733265675 | -0.282025146955814 | 0.143470680488333 | 0.373749368113514 |
| P40925 | P40925 | MDHC_HUMAN | Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase) | MDH1 | gluconeogenesis [GO:0006094]; malate metabolic process [GO:0006108]; NADH metabolic process [GO:0006734]; NADP metabolic process [GO:0006739]; oxaloacetate metabolic process [GO:0006107]; tricarboxylic acid cycle [GO:0006099] | centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; mitochondrion [GO:0005739] | diiodophenylpyruvate reductase activity [GO:0047860]; hydroxyphenylpyruvate reductase activity [GO:0047995]; L-malate dehydrogenase activity [GO:0030060]; malic enzyme activity [GO:0004470] | 141712.269711002 | 0.106455092782023 | 0.144128114865 | 0.375289475563001 |
| Q9NPI6 | Q9NPI6 | DCP1A_HUMAN | mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) | DCP1A | deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087]; methylguanosine-cap decapping [GO:0110156]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; protein localization to cytoplasmic stress granule [GO:1903608] | cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932] | 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity [GO:0140933]; enzyme activator activity [GO:0008047]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; mRNA binding [GO:0003729] | 6674.84421832555 | 0.170247017314466 | 0.144202803372237 | 0.375311476300917 |
| Q9NVT9 | Q9NVT9 | ARMC1_HUMAN | Armadillo repeat-containing protein 1 | ARMC1 | intracellular distribution of mitochondria [GO:0048312] | cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] | metal ion binding [GO:0046872] | 15965.0575814678 | -0.168445443542469 | 0.144901351190135 | 0.376610576074911 |
| Q9HBH5 | Q9HBH5 | RDH14_HUMAN | Retinol dehydrogenase 14 (EC 1.1.1.300) (Alcohol dehydrogenase PAN2) (Short chain dehydrogenase/reductase family 7C member 4) | RDH14 | osteoblast differentiation [GO:0001649] | cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | 11-cis-retinol dehydrogenase activity [GO:0102354]; NADP-retinol dehydrogenase activity [GO:0052650] | 13098.62855413865 | -0.168841627115291 | 0.14480338527179 | 0.376610576074911 |
| O95183 | O95183 | VAMP5_HUMAN | Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin) | VAMP5 | cell differentiation [GO:0030154]; Golgi to plasma membrane protein transport [GO:0043001]; muscle organ development [GO:0007517]; skeletal muscle tissue development [GO:0007519] | cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intercalated disc [GO:0014704]; late endosome [GO:0005770]; organelle membrane [GO:0031090]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] | 8168.60920782831 | -0.997788126445496 | 0.144836071849724 | 0.376610576074911 | |
| O75937 | O75937 | DNJC8_HUMAN | DnaJ homolog subfamily C member 8 (Splicing protein spf31) | DNAJC8 | cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | Hsp70 protein binding [GO:0030544] | 11807.421156252749 | 0.394673927436283 | 0.145078988142984 | 0.376726648404283 | |
| Q9NX20 | Q9NX20 | RM16_HUMAN | Large ribosomal subunit protein uL16m (39S ribosomal protein L16, mitochondrial) (L16mt) (MRP-L16) | MRPL16 | mitochondrial translation [GO:0032543] | cytosolic large ribosomal subunit [GO:0022625]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739] | rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] | 10650.464531784452 | 0.21856159464391 | 0.145045958286051 | 0.376726648404283 |
| Q9BWU0 | Q9BWU0 | NADAP_HUMAN | Kanadaptin (Human lung cancer oncogene 3 protein) (HLC-3) (Kidney anion exchanger adapter protein) (Solute carrier family 4 anion exchanger member 1 adapter protein) | SLC4A1AP | maintenance of RNA location [GO:0051237]; miRNA processing [GO:0035196]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of protein dephosphorylation [GO:0035308] | cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] | mRNA binding [GO:0003729]; protein serine/threonine phosphatase inhibitor activity [GO:0004865] | 2338.261404937105 | 0.376508531952236 | 0.145474711355429 | 0.377062998417136 |
| Q9UKE5 | Q9UKE5 | TNIK_HUMAN | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | TNIK | actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; microvillus assembly [GO:0030033]; neuron projection morphogenesis [GO:0048812]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein phosphorylation [GO:0001934]; protein autophosphorylation [GO:0046777]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of dendrite morphogenesis [GO:0048814]; regulation of MAPK cascade [GO:0043408]; response to organonitrogen compound [GO:0010243]; Wnt signaling pathway [GO:0016055] | apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density, intracellular component [GO:0099092]; presynapse [GO:0098793]; recycling endosome [GO:0055037] | ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | 10890.55032693415 | 0.232041629514713 | 0.145362524552695 | 0.377062998417136 |
| Q9BQA1 | Q9BQA1 | MEP50_HUMAN | Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50) | WDR77 | epithelial cell proliferation involved in prostate gland development [GO:0060767]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; oocyte axis specification [GO:0007309]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; protein polyubiquitination [GO:0000209]; regulation of transcription by RNA polymerase II [GO:0006357]; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [GO:0060528]; spliceosomal snRNP assembly [GO:0000387]; ubiquitin-dependent protein catabolic process [GO:0006511] | Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | methyl-CpG binding [GO:0008327]; nuclear receptor coactivator activity [GO:0030374]; ubiquitin ligase-substrate adaptor activity [GO:1990756] | 14846.399447700649 | 0.165734538568671 | 0.145455133261171 | 0.377062998417136 |
| O14653 | O14653 | GOSR2_HUMAN | Golgi SNAP receptor complex member 2 (27 kDa Golgi SNARE protein) (Membrin) | GOSR2 | intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; vesicle fusion [GO:0006906] | cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; SNARE complex [GO:0031201] | SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] | 46308.29507876655 | 0.217459509057031 | 0.146014974366146 | 0.377944652699215 |
| Q8WUA7 | Q8WUA7 | TB22A_HUMAN | TBC1 domain family member 22A | TBC1D22A | 14-3-3 protein binding [GO:0071889]; GTPase activator activity [GO:0005096]; protein homodimerization activity [GO:0042803] | 7604.335271794305 | -0.215131064797826 | 0.146474580663012 | 0.378961175359191 | ||
| Q9Y616 | Q9Y616 | IRAK3_HUMAN | Interleukin-1 receptor-associated kinase 3 (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) (Inactive IL-1 receptor-associated kinase 3) | IRAK3 | cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of innate immune response [GO:0045824]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein-containing complex disassembly [GO:0043242]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of cytokine production [GO:0001819]; positive regulation of macrophage tolerance induction [GO:0010933]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein phosphorylation [GO:0006468]; regulation of protein-containing complex disassembly [GO:0043244]; response to exogenous dsRNA [GO:0043330]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to peptidoglycan [GO:0032494]; response to virus [GO:0009615]; Toll signaling pathway [GO:0008063] | cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activity [GO:0004674] | 6633.69120550476 | -0.272283098788255 | 0.14698271697854 | 0.380092751110767 |
| P06748 | P06748 | NPM_HUMAN | Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) | NPM1 | cellular response to UV [GO:0034644]; cellular senescence [GO:0090398]; centrosome cycle [GO:0007098]; chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]; intracellular protein transport [GO:0006886]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of centrosome duplication [GO:0010826]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; nucleocytoplasmic transport [GO:0006913]; nucleosome assembly [GO:0006334]; positive regulation of cell cycle G2/M phase transition [GO:1902751]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; protein localization [GO:0008104]; regulation of centriole replication [GO:0046599]; regulation of centrosome duplication [GO:0010824]; regulation of eIF2 alpha phosphorylation by dsRNA [GO:0060735]; regulation of endodeoxyribonuclease activity [GO:0032071]; regulation of endoribonuclease activity [GO:0060699]; regulation of mRNA stability involved in cellular response to UV [GO:1902629]; ribosomal large subunit biogenesis [GO:0042273]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit biogenesis [GO:0042274]; ribosomal small subunit export from nucleus [GO:0000056]; ribosomal subunit export from nucleus [GO:0000054]; ribosome assembly [GO:0042255]; signal transduction [GO:0007165] | centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; granular component [GO:0001652]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; ribonucleoprotein complex [GO:1990904]; spindle pole centrosome [GO:0031616] | chromatin binding [GO:0003682]; core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription factor binding [GO:0140297]; histone binding [GO:0042393]; NF-kappaB binding [GO:0051059]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; protein self-association [GO:0043621]; ribosomal large subunit binding [GO:0043023]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; Tat protein binding [GO:0030957]; transcription coactivator activity [GO:0003713]; unfolded protein binding [GO:0051082] | 1009377.8468761521 | 0.122328793676168 | 0.14704611903191 | 0.380092751110767 |
| Q14746 | Q14746 | COG2_HUMAN | Conserved oligomeric Golgi complex subunit 2 (COG complex subunit 2) (Component of oligomeric Golgi complex 2) (Low density lipoprotein receptor defect C-complementing protein) | COG2 | glycosylation [GO:0070085]; Golgi organization [GO:0007030]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301] | Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; Golgi transport complex [GO:0017119]; trans-Golgi network membrane [GO:0032588] | protein-containing complex binding [GO:0044877] | 7306.276994687794 | -0.250950595535131 | 0.147133400728991 | 0.380144937770389 |
| Q96BH1 | Q96BH1 | RNF25_HUMAN | E3 ubiquitin-protein ligase RNF25 (EC 2.3.2.27) (RING finger protein 25) (RING finger protein AO7) | RNF25 | positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein K6-linked ubiquitination [GO:0085020]; protein ubiquitination [GO:0016567]; rescue of stalled ribosome [GO:0072344]; ubiquitin-dependent protein catabolic process [GO:0006511] | cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; nucleus [GO:0005634] | metal ion binding [GO:0046872]; NF-kappaB binding [GO:0051059]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] | 3269.547052159675 | 0.694243823683523 | 0.147727508634826 | 0.381505954386929 |
| O43852 | O43852 | CALU_HUMAN | Calumenin (Crocalbin) (IEF SSP 9302) | CALU | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; melanosome [GO:0042470]; membrane [GO:0016020]; sarcoplasmic reticulum lumen [GO:0033018] | calcium ion binding [GO:0005509] | 434559.553599748 | 0.281000154481458 | 0.148185676134138 | 0.382514825046025 | |
| Q9BRQ6 | Q9BRQ6 | MIC25_HUMAN | MICOS complex subunit MIC25 (Coiled-coil-helix cristae morphology protein 1) (Coiled-coil-helix-coiled-coil-helix domain-containing protein 6) | CHCHD6 | cristae formation [GO:0042407]; DNA damage response [GO:0006974]; inner mitochondrial membrane organization [GO:0007007] | cytosol [GO:0005829]; MIB complex [GO:0140275]; MICOS complex [GO:0061617]; mitochondrial crista junction [GO:0044284]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; SAM complex [GO:0001401] | 13195.32763392595 | -0.253134638134441 | 0.148326797347037 | 0.382534134178775 | |
| Q8N684 | Q8N684 | CPSF7_HUMAN | Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit) | CPSF7 | messenger ribonucleoprotein complex assembly [GO:1990120]; mRNA 3'-end processing [GO:0031124]; mRNA alternative polyadenylation [GO:0110104]; protein heterotetramerization [GO:0051290]; protein tetramerization [GO:0051262] | cytoplasm [GO:0005737]; membrane [GO:0016020]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; mRNA cleavage factor complex [GO:0005849]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | mRNA binding [GO:0003729]; RNA binding [GO:0003723] | 22631.043042826197 | 0.157383464087337 | 0.148328184396535 | 0.382534134178775 |
| P08708 | P08708 | RS17_HUMAN | Small ribosomal subunit protein eS17 (40S ribosomal protein S17) | RPS17 | cytoplasmic translation [GO:0002181]; erythrocyte homeostasis [GO:0034101]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412]; translational initiation [GO:0006413] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]; synapse [GO:0045202] | RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] | 163609.112370478 | 0.340123139471722 | 0.148939832603284 | 0.383936802334034 |
| P12931 | P12931 | SRC_HUMAN | Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) | SRC | adherens junction organization [GO:0034332]; angiotensin-activated signaling pathway [GO:0038166]; bone resorption [GO:0045453]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; cell-cell adhesion [GO:0098609]; cellular response to fatty acid [GO:0071398]; cellular response to fluid shear stress [GO:0071498]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to progesterone stimulus [GO:0071393]; cellular response to prolactin [GO:1990646]; DNA biosynthetic process [GO:0071897]; entry of bacterium into host cell [GO:0035635]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERBB2 signaling pathway [GO:0038128]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; focal adhesion assembly [GO:0048041]; forebrain development [GO:0030900]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; interleukin-6-mediated signaling pathway [GO:0070102]; intestinal epithelial cell development [GO:0060576]; intracellular signal transduction [GO:0035556]; learning or memory [GO:0007611]; leukocyte migration [GO:0050900]; macroautophagy [GO:0016236]; myoblast proliferation [GO:0051450]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of gene expression [GO:0010629]; negative regulation of hippo signaling [GO:0035331]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of mitochondrial depolarization [GO:0051902]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; neurotrophin TRK receptor signaling pathway [GO:0048011]; odontogenesis [GO:0042476]; oogenesis [GO:0048477]; osteoclast development [GO:0036035]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet activation [GO:0030168]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone resorption [GO:0045780]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cytokine production [GO:0001819]; positive regulation of dephosphorylation [GO:0035306]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of integrin activation [GO:0033625]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of male germ cell proliferation [GO:2000256]; positive regulation of non-membrane spanning protein tyrosine kinase activity [GO:1903997]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of ovarian follicle development [GO:2000386]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000588]; positive regulation of podosome assembly [GO:0071803]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein processing [GO:0010954]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of protein transport [GO:0051222]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; primary ovarian follicle growth [GO:0001545]; progesterone receptor signaling pathway [GO:0050847]; protein autophosphorylation [GO:0046777]; protein destabilization [GO:0031648]; regulation of bone resorption [GO:0045124]; regulation of caveolin-mediated endocytosis [GO:2001286]; regulation of cell projection assembly [GO:0060491]; regulation of cell-cell adhesion [GO:0022407]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of epithelial cell migration [GO:0010632]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of toll-like receptor 3 signaling pathway [GO:0034139]; regulation of vascular permeability [GO:0043114]; response to acidic pH [GO:0010447]; response to electrical stimulus [GO:0051602]; response to interleukin-1 [GO:0070555]; response to mechanical stimulus [GO:0009612]; response to mineralocorticoid [GO:0051385]; response to nutrient levels [GO:0031667]; response to xenobiotic stimulus [GO:0009410]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165]; skeletal muscle cell proliferation [GO:0014856]; spermatogenesis [GO:0007283]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; stress fiber assembly [GO:0043149]; substrate adhesion-dependent cell spreading [GO:0034446]; T cell costimulation [GO:0031295]; transcytosis [GO:0045056]; transforming growth factor beta receptor signaling pathway [GO:0007179]; uterus development [GO:0060065]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] | actin filament [GO:0005884]; caveola [GO:0005901]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic filopodium [GO:1902737]; dendritic growth cone [GO:0044294]; extracellular exosome [GO:0070062]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; late endosome [GO:0005770]; lysosome [GO:0005764]; membrane raft [GO:0045121]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; podosome [GO:0002102]; postsynaptic specialization, intracellular component [GO:0099091]; ruffle membrane [GO:0032587]; synaptic membrane [GO:0097060] | ATP binding [GO:0005524]; ATPase binding [GO:0051117]; BMP receptor binding [GO:0070700]; cadherin binding [GO:0045296]; connexin binding [GO:0071253]; enzyme binding [GO:0019899]; ephrin receptor binding [GO:0046875]; heme binding [GO:0020037]; insulin receptor binding [GO:0005158]; integrin binding [GO:0005178]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; nuclear estrogen receptor binding [GO:0030331]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; phosphoprotein binding [GO:0051219]; protein kinase activity [GO:0004672]; protein kinase C binding [GO:0005080]; protein tyrosine kinase activity [GO:0004713]; scaffold protein binding [GO:0097110]; SH2 domain binding [GO:0042169]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325] | 14664.800847846149 | 0.0710930802556648 | 0.149438039857925 | 0.385045899879492 |
| Q9NWV8 | Q9NWV8 | BABA1_HUMAN | BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) | BABAM1 | cell division [GO:0051301]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; hematopoietic stem cell proliferation [GO:0071425]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; positive regulation of DNA repair [GO:0045739]; regulation of DNA repair [GO:0006282]; response to ionizing radiation [GO:0010212] | BRCA1-A complex [GO:0070531]; BRISC complex [GO:0070552]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | 15458.786291621549 | 0.367480637452077 | 0.14988720597467 | 0.386027685932946 |
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| Q15149 | |||||||||
| Q99715 | |||||||||
| P02452 | |||||||||
| P02751 | |||||||||
| P98160 | |||||||||
| P08123 | |||||||||
| P02461 | |||||||||
| P07996 | |||||||||
| Q8WWI1 | |||||||||
| P05997 | |||||||||
| P20908 | |||||||||
| Q8WUJ3 | |||||||||
| P21333 | |||||||||
| O75369 | |||||||||
| Q15063 | |||||||||
| P02786 | |||||||||
| Q12884 | |||||||||
| P12814 | |||||||||
| Q9UDY2 | |||||||||
| Q14195 | |||||||||
| Q02952 | |||||||||
| Q9NZM1 | |||||||||
| P35579 | |||||||||
| P35354 | |||||||||
| P47895 | |||||||||
| Q09666 | |||||||||
| P11717 | |||||||||
| Q14112 | |||||||||
| Q13620 | |||||||||
| P43490 | |||||||||
| Q3SY69 | |||||||||
| P17812 | |||||||||
| P21980 | |||||||||
| Q16647 | |||||||||
| P01024 | |||||||||
| Q5SW79 | |||||||||
| P06396 | |||||||||
| P12111 | |||||||||
| P35221 | |||||||||
| P12429 | |||||||||
| P78559 | |||||||||
| Q76M96 | |||||||||
| Q16881 | |||||||||
| P07093 | |||||||||
| P27487 | |||||||||
| P15144 | |||||||||
| Q9H5V8 | |||||||||
| P08729 | |||||||||
| Q04828 | |||||||||
| O94925 | |||||||||
| P08473 | |||||||||
| Q8IVL5 | |||||||||
| P35442 | |||||||||
| O60716 | |||||||||
| P08253 | |||||||||
| Q16822 | |||||||||
| Q9UJ72 | |||||||||
| Q9Y617 | |||||||||
| Q8WX93 | |||||||||
| Q32MZ4 | |||||||||
| Q6P179 | |||||||||
| P48681 | |||||||||
| O95340 | |||||||||
| P21580 | |||||||||
| Q00341 | |||||||||
| P49748 | |||||||||
| O43854 | |||||||||
| P07942 | |||||||||
| Q96KC8 | |||||||||
| Q96PD2 | |||||||||
| Q13418 | |||||||||
| Q7Z7G0 | |||||||||
| Q04446 | |||||||||
| P19022 | |||||||||
| O00469 | |||||||||
| Q8WUF5 | |||||||||
| Q14767 | |||||||||
| Q13308 | |||||||||
| P46940 | |||||||||
| Q9NZ08 | |||||||||
| O60488 | |||||||||
| P35222 | |||||||||
| Q9H4M9 | |||||||||
| Q9NZU5 | |||||||||
| Q15113 | |||||||||
| O94808 | |||||||||
| Q9UI42 | |||||||||
| Q15417 | |||||||||
| Q15582 | |||||||||
| P35908 | |||||||||
| P00750 | |||||||||
| Q9UHD8 | |||||||||
| P11047 | |||||||||
| Q8N6G6 | |||||||||
| Q05682 | |||||||||
| P17342 | |||||||||
| Q16363 | |||||||||
| Q9NR12 | |||||||||
| P05362 | |||||||||
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