HepG2 acyl-CoA/acylcarnitine measurements statistical significance, palmitate/no-glucose (Fig. S4)

Selected Cell

Cell:

Value:

p values	points
0.1<p	0
0.1> p >0.05	1
0.01< p<0.05	2
0.005 < p <0.01	3
<0.005	4

Negative if down regulated
Positive if up regulated

Summary										p values										Points
											EXP1			EXP2			EXP3				EXP1			EXP2			EXP3
Species	KO4_1	KO4_2	KO4_3	KO9_1	KO9_2	KO9_3	KO21_1	KO21_2	KO21_3		KO4_1	KO9_1	KO21_1	KO4_2	KO9_2	KO21_2	KO4_3	KO9_3	KO21_3		KO4_1	KO9_1	KO21_1	KO4_2	KO9_2	KO21_2	KO4_3	KO9_3	KO21_3
L-Car	0	-3	-4	0	-2	-4	0	0	0	L-Car	0.1174	0.1052	0.4756	0.0067	0.012	0.6022	<0,0001	<0,0001	0.1695	L-Car	0	0	0	-3	-2	0	-4	-4	0
C2:0	-4	-4	-4	-3	-4	-4	-2	-4	-4	C2:0	0.0035	0.0058	0.011	<0,0001	<0,0001	<0,0001	<0,0001	<0,0001	<0,0001	C2:0	-4	-3	-2	-4	-4	-4	-4	-4	-4
C3:0	-2	-4	-4	-2	-4	-4	2	-2	-4	C3:0	0.0131	0.0187	0.0192	0.001	8.0E-4	0.0195	1.0E-4	<0,0001	0.0014	C3:0	-2	-2	2	-4	-4	-2	-4	-4	-4
Malonyl	-2	-4	-4	-1	-4	-4	-2	-4	-4	Malonyl	0.0251	0.0502	0.0447	3.0E-4	<0,0001	3.0E-4	<0,0001	<0,0001	<0,0001	Malonyl	-2	-1	-2	-4	-4	-4	-4	-4	-4
C4:0	-3	-4	-4	-2	-4	-4	-2	-4	-4	C4:0	0.0059	0.0102	0.0266	9.0E-4	9.0E-4	0.0025	<0,0001	<0,0001	<0,0001	C4:0	-3	-2	-2	-4	-4	-4	-4	-4	-4
C5:0	-3	-4	-4	-4	-4	-4	0	-4	-4	C5:0	0.0068	0.0048	0.4262	2.0E-4	3.0E-4	0.0034	<0,0001	1.0E-4	0.0024	C5:0	-3	-4	0	-4	-4	-4	-4	-4	-4
C5:1	-1	-4	-4	0	-4	-4	2	0	0	C5:1	0.0671	0.181	0.038	7.0E-4	9.0E-4	0.3057	2.0E-4	<0,0001	0.8804	C5:1	-1	0	2	-4	-4	0	-4	-4	0
C6:0	0	4	4	1	4	4	4	4	4	C6:0	0.7671	0.0707	<0,0001	0.0023	<0,0001	<0,0001	4.0E-4	2.0E-4	<0,0001	C6:0	0	1	4	4	4	4	4	4	4
C8:0	4	4	4	4	4	4	4	4	4	C8:0	0.0013	<0,0001	6.0E-4	1.0E-4	<0,0001	<0,0001	<0,0001	<0,0001	<0,0001	C8:0	4	4	4	4	4	4	4	4	4
C8:1	4			4			4			C8:1	0.0016	2.0E-4	<0,0001							C8:1	4	4	4
C10:0	0	4	4	0	4	4	0	4	4	C10:0	>0,9999	0.4799	0.5069	<0,0001	<0,0001	<0,0001	<0,0001	<0,0001	<0,0001	C10:0	0	0	0	4	4	4	4	4	4
C10:1										C10:1										C10:1
C12:0	-3	-2	-4	-3	-2	-4	-2	0	-2	C12:0	0.0096	0.0086	0.013	0.0108	0.0238	0.1223	<0,0001	<0,0001	0.0263	C12:0	-3	-3	-2	-2	-2	0	-4	-4	-2
C12:1	-2	-2	-1	-2	-1	0	-1	0	0	C12:1	0.0225	0.0405	0.0549	0.0228	0.0518	0.1511	0.069	0.1144	0.997	C12:1	-2	-2	-1	-2	-1	0	-1	0	0
C14:0	-4	-4	-4	-4	-4	-4	-4	-4	-4	C14:0	<0,0001	<0,0001	<0,0001	2.0E-4	1.0E-4	3.0E-4	<0,0001	<0,0001	7.0E-4	C14:0	-4	-4	-4	-4	-4	-4	-4	-4	-4
C14:1	-4	-2	-3	-4	-2	-1	-4	-1	-1	C14:1	0.0025	0.0015	0.0033	0.0147	0.0292	0.0724	0.0068	0.0807	0.0922	C14:1	-4	-4	-4	-2	-2	-1	-3	-1	-1
C14:2	-2	-2	0	0	0	0	-2	0	0	C14:2	0.0177	>0,9999	0.0299	0.0259	0.1799	0.1883	0.1621	>0,9999	0.5349	C14:2	-2	0	-2	-2	0	0	0	0	0
C16:0	-4	-4	-2	-4	-1	0	-3	0	0	C16:0	0.0046	0.0041	0.0085	0.0043	0.0627	0.1585	0.035	0.9553	0.6879	C16:0	-4	-4	-3	-4	-1	0	-2	0	0
C16:1	-4	-1	-2	0	0	0	-2	-2	-2	C16:1	0.0019	0.1441	0.0469	0.0525	0.9036	0.0324	0.0246	0.1793	0.0213	C16:1	-4	0	-2	-1	0	-2	-2	0	-2
C18:0	-4	0	-3	-4	0	-1	-4	0	-2	C18:0	0.0011	0.001	0.0024	0.9965	0.9684	>0,9999	0.0091	0.0558	0.0168	C18:0	-4	-4	-4	0	0	0	-3	-1	-2
C18:1	-4	0	0	-2	0	0	-1	0	0	C18:1	<0,0001	0.0243	0.0724	0.992	0.7468	0.9881	0.2647	0.7129	0.3341	C18:1	-4	-2	-1	0	0	0	0	0	0
C18:1-OH	-4	0	0	-4	0	0	-3	0	0	C18:1-OH	6.0E-4	0.0026	0.0057	0.5499	0.9461	0.9367	0.9099	0.9998	0.3702	C18:1-OH	-4	-4	-3	0	0	0	0	0	0
C18:2	-4	0	0	-2	0	0	-2	0	0	C18:2	9.0E-4	0.0459	0.01	0.7982	0.9555	0.4865	0.9919	0.1311	0.9999	C18:2	-4	-2	-2	0	0	0	0	0	0
C7-DC	0	0	0	0	0	0	0	0	0	C7-DC	0.3539	0.9963	0.9911	0.3907	0.6106	0.7521	0.9933	0.998	0.9986	C7-DC	0	0	0	0	0	0	0	0	0

																					0.1<p	0
																					0.1> p >0.05	1
																					0.01< p<0.05	2
																					0.005 < p <0.01	3
																					<0.005	4

																					Negative if down regulated
																					Positive if up regulated

Summary										p values										Points
	KO4			KO9			KO21				EXP1			EXP2			EXP3				EXP1			EXP2			EXP3
Species	KO4_1	KO4_2	KO4_3	KO9_1	KO9_2	KO9_3	KO21_1	KO21_2	KO21_3		KO4_1	KO9_1	KO21_1	KO4_2	KO9_2	KO21_2	KO4_3	KO9_3	KO21_3		KO4_1	KO9_1	KO21_1	KO4_2	KO9_2	KO21_2	KO4_3	KO9_3	KO21_3
CoASH	0	-2	0	0	-3	-1	-2	-4	0	CoASH	0.1255	0.7325	0.0403	0.015	0.0071	0.0018	0.8662	0.0527	0.1267	CoASH	0	0	-2	-2	-3	-4	0	-1	0
C2:0	-2	-4	-4	-1	-4	-4	-1	-4	-4	C2:0	0.0285	0.0507	0.0807	<0,0001	<0,0001	<0,0001	<0,0001	7.0E-4	4.0E-4	C2:0	-2	-1	-1	-4	-4	-4	-4	-4	-4
C4:0	-4	-4	0	0	-4	0	-2	-3	0	C4:0	0.0034	0.5456	0.0117	0.0014	0.0025	0.0075	0.4894	0.2654	0.8345	C4:0	-4	0	-2	-4	-4	-3	0	0	0
C6:0	2	4	4	4	4	4	4	4	3	C6:0	0.0378	0.0017	1.0E-4	2.0E-4	<0,0001	<0,0001	<0,0001	3.0E-4	0.0074	C6:0	2	4	4	4	4	4	4	4	3
C8:0	4	4	4	4	4	4	4	4	4	C8:0	0.0011	0.003	2.0E-4	<0,0001	<0,0001	<0,0001	<0,0001	4.0E-4	0.0036	C8:0	4	4	4	4	4	4	4	4	4
C8:1		2	4		4	3		3	3	C8:1				0.0119	0.0048	0.0053	0.0012	0.0053	0.0073	C8:1				2	4	3	4	3	3
C10:0	0	3	4	1	4	4	0	3	4	C10:0	0.2745	0.0959	0.7683	0.0055	0.0017	0.0051	0.0015	3.0E-4	0.005	C10:0	0	1	0	3	4	3	4	4	4
C10:1	0	2	3	2	2	2	0	0	2	C10:1	0.1257	0.0372	0.9086	0.0112	0.0135	0.4161	0.0083	0.0169	0.0135	C10:1	0	2	0	2	2	0	3	2	2
C12:0	-4	-1	0	-4	0	0	-3	0	0	C12:0	0.0044	0.0035	0.0059	0.0874	0.3567	0.5273	0.96	0.9593	0.8982	C12:0	-4	-4	-3	-1	0	0	0	0	0
C12:1	0	0	0	0	4	0	0	0	0	C12:1	0.2024	0.2534	0.4777	0.9997	0.0036	0.5049	0.8461	0.9635	>0,9999	C12:1	0	0	0	0	4	0	0	0	0
C14:0	-3	-4	-1	-2	-4	0	-3	-4	0	C14:0	0.0059	0.0123	0.0094	2.0E-4	<0,0001	0.0013	0.0864	0.1075	0.2297	C14:0	-3	-2	-3	-4	-4	-4	-1	0	0
C14:1	-2	-2	0	0	0	0	-2	0	0	C14:1	0.0119	0.3798	0.0336	0.0129	0.742	0.1638	0.2433	0.7481	0.3809	C14:1	-2	0	-2	-2	0	0	0	0	0
C16:0	-2	-4	-1	0	-3	0	0	-2	0	C16:0	0.0169	0.4263	0.1655	<0,0001	0.0059	0.0147	0.0981	0.2874	0.2246	C16:0	-2	0	0	-4	-3	-2	-1	0	0
C16:1	-2	-4	0	0	-3	0	0	-4	0	C16:1	0.012	0.7866	0.3841	0.001	0.0079	<0,0001	0.2043	0.4711	0.127	C16:1	-2	0	0	-4	-3	-4	0	0	0
C18:0	0	-2	0	1	0	0	0	-1	0	C18:0	0.4921	0.0992	0.991	0.0164	0.8107	0.0829	0.7397	0.9364	0.8488	C18:0	0	1	0	-2	0	-1	0	0	0
C18:1	-1	-4	0	0	0	0	0	-3	0	C18:1	0.0634	0.1323	0.98	0.0012	0.1971	0.0092	0.8076	0.8433	0.1761	C18:1	-1	0	0	-4	0	-3	0	0	0

																				0.1<p	0
																				0.1> p >0.05	1
																				0.01< p<0.05	2
																				0.005 < p <0.01	3
																				p<0.005	4

																				Negative if down regulated
																				Positive if up regulated