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| Sample | t (s) | Iv | Im | matrix norm | Vv | Vm | Vv% | SAv | SSA (µm-1) | d (µm) | R | P (μm/s) | P (cm/s) | |||||
| ROI1 (spheroid 1) | 0 | 1441.67 | 208.458 | 7082340.852 | 3.3387613708E7 | 0.17500244141613386 | 1181423.121 | 0.029192598159418343 | 23.97901556558414 | 28.260504737489388 | ||||||||
| 720 | 1615.595 | 235.116 | 209.80486057458708 | 8.484714614401622E-4 | 8.484714614401623E-8 | |||||||||||||
| Iv | vascular intensity | 10.765383651224468 | ||||||||||||||||
| Im | matrix intensity | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| Vv | vascular volume | 1 | Classified image | 85 | 358405 | 7082340.852 | 227226 | 1181423.121 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vm | matrix volume | 2 | Classified image | 155 | 1689595 | 3.3387613708E7 | 780880 | 3419374.393 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vv% | vascular density (volume fraction) | 3 | Classified image:DUP_ROI1_01.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1441.67 | 781.068 | 136 | 4095 | 516701725 | |||
| SAv | vascular surface area | 4 | Classified image:DUP_ROI1_01.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 208.458 | 100.126 | 129 | 2563 | 352210090 | |||
| SSA | vasular specific surface area | |||||||||||||||||
| d | average vessel diameter | |||||||||||||||||
| R | morphological ratio for permeability | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| 1 | Classified image | 85 | 358405 | 7082340.852 | 227226 | 1181423.121 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 2 | Classified image | 155 | 1689595 | 3.338761371E7 | 780880 | 3419374.393 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 3 | Classified image:DUP_ROI1_02.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1615.595 | 838.045 | 138 | 4095 | 579037171 | |||||
| 4 | Classified image:DUP_ROI1_02.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 235.116 | 139.078 | 130 | 2531 | 397250668 | |||||
| Sample | t (s) | Iv | Im | matrix norm | Vv | Vm | Vv% | SAv | SSA (µm-1) | d (µm) | R | P (μm/s) | P (cm/s) | |||||
| ROI2 (surrounding of 1) | 0 | 1681.73 | 191.504 | 6646103.197 | 3.382385136E7 | 0.16422314454638887 | 1234039.136 | 0.03049272354042095 | 21.54260105086327 | 27.409058897140195 | ||||||||
| 720 | 1785.409 | 205.77 | 193.82090159733707 | 3.6442797772750444E-4 | 3.644279777275044E-8 | |||||||||||||
| Iv | vascular intensity | 5.807016767586591 | ||||||||||||||||
| Im | matrix intensity | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| Vv | vascular volume | 1 | Classified image | 85 | 336329 | 6646103.197 | 227258 | 1234039.136 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vm | matrix volume | 2 | Classified image | 155 | 1711671 | 3.382385136E7 | 800768 | 3542620.087 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vv% | vascular density (volume fraction) | 3 | Classified image:DUP_ROI2_01.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1681.73 | 934.721 | 140 | 4095 | 565614580 | |||
| SAv | vascular surface area | 4 | Classified image:DUP_ROI2_01.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 191.504 | 86.389 | 129 | 2152 | 327791689 | |||
| SSA | vasular specific surface area | |||||||||||||||||
| d | average vessel diameter | |||||||||||||||||
| R | morphological ratio for permeability | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| 1 | Classified image | 85 | 336329 | 6646103.197 | 227258 | 1234039.136 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 2 | Classified image | 155 | 1711671 | 3.382385136E7 | 800768 | 3542620.087 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 3 | Classified image:DUP_ROI2_02.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1785.409 | 977.809 | 139 | 4095 | 600484849 | |||||
| 4 | Classified image:DUP_ROI2_02.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 205.77 | 103.104 | 129 | 2514 | 352211154 | |||||
| Sample | t (s) | Iv | Im | matrix norm | Vv | Vm | Vv% | SAv | SSA (µm-1) | d (µm) | R | P (μm/s) | P (cm/s) | |||||
| ROI3 (surrounding of 1) | 0 | 1740.59 | 200.681 | 5118184.566 | 3.535176999E7 | 0.12646875001843033 | 863745.906 | 0.021342892906014953 | 23.702269523694852 | 40.92843710682665 | ||||||||
| 720 | 1884.388 | 254.435 | 235.01901765984502 | 0.00198430485199699 | 1.98430485199699E-7 | Side leakage at 12 min | ||||||||||||
| Iv | vascular intensity | 7.631018664945861 | ||||||||||||||||
| Im | matrix intensity | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| Vv | vascular volume | 1 | Classified image | 85 | 259008 | 5118184.566 | 163108 | 863745.906 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vm | matrix volume | 2 | Classified image | 155 | 1788992 | 3.535176999E7 | 794278 | 3415668.125 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vv% | vascular density (volume fraction) | 3 | Classified image:DUP_ROI3_01.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1740.59 | 888.546 | 136 | 4095 | 450826648 | |||
| SAv | vascular surface area | 4 | Classified image:DUP_ROI3_01.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 200.681 | 94.766 | 130 | 2269 | 359017111 | |||
| SSA | vasular specific surface area | |||||||||||||||||
| d | average vessel diameter | |||||||||||||||||
| R | morphological ratio for permeability | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| 1 | Classified image | 85 | 259008 | 5118184.566 | 163108 | 863745.906 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 2 | Classified image | 155 | 1788992 | 3.535176999E7 | 794278 | 3415668.125 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 3 | Classified image:DUP_ROI3_02.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1884.388 | 916.114 | 143 | 4095 | 488071692 | |||||
| 4 | Classified image:DUP_ROI3_02.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 254.435 | 159.78 | 130 | 2236 | 455182404 | |||||
| Sample | t (s) | Iv | Im | matrix norm | Vv | Vm | Vv% | SAv | SSA (µm-1) | d (µm) | R | P (μm/s) | P (cm/s) | |||||
| ROI4 (spheroid 2) | 0 | 1257.923 | 217.086 | 5228607.469 | 3.524134709E7 | 0.12919726562522724 | 927599.035 | 0.022920683877904524 | 22.546843072125444 | 37.992004907594584 | ||||||||
| 720 | 1490.303 | 296.096 | 249.92633619337812 | 0.004005521394679165 | 4.005521394679165E-7 | |||||||||||||
| Iv | vascular intensity | 15.592802269068779 | ||||||||||||||||
| Im | matrix intensity | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| Vv | vascular volume | 1 | Classified image | 85 | 264596 | 5228607.469 | 174086 | 927599.035 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vm | matrix volume | 2 | Classified image | 155 | 1783404 | 3.524134709E7 | 798722 | 3447686.137 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vv% | vascular density (volume fraction) | 3 | Classified image:DUP_ROI4_01.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1257.923 | 683.562 | 140 | 4095 | 332841408 | |||
| SAv | vascular surface area | 4 | Classified image:DUP_ROI4_01.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 217.086 | 113.295 | 132 | 2382 | 387152709 | |||
| SSA | vasular specific surface area | |||||||||||||||||
| d | average vessel diameter | |||||||||||||||||
| R | morphological ratio for permeability | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| 1 | Classified image | 85 | 264596 | 5228607.469 | 174086 | 927599.035 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 2 | Classified image | 155 | 1783404 | 3.524134709E7 | 798722 | 3447686.137 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 3 | Classified image:DUP_ROI4_02.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1490.303 | 742.494 | 141 | 4095 | 394328172 | |||||
| 4 | Classified image:DUP_ROI4_02.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 296.096 | 206.341 | 132 | 3399 | 528058018 | |||||
| Sample | t (s) | Iv | Im | matrix norm | Vv | Vm | Vv% | SAv | SSA (µm-1) | d (µm) | R | P (μm/s) | P (cm/s) | |||||
| ROI5 (surrounding of 2) | 0 | 1808.804 | 197.265 | 8771902.172 | 3.1698052388E7 | 0.21675097655459288 | 1436314.414 | 0.03549088279480391 | 24.428919146111138 | 22.069020598159923 | ||||||||
| 720 | 1775.085 | 209.723 | 213.7068373018757 | 3.127231916601748E-4 | 3.127231916601748E-8 | |||||||||||||
| Iv | vascular intensity | -1.8995710064588487 | ||||||||||||||||
| Im | matrix intensity | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| Vv | vascular volume | 1 | Classified image | 85 | 443906 | 8771902.172 | 275412 | 1436314.414 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vm | matrix volume | 2 | Classified image | 155 | 1604094 | 3.1698052388E7 | 762200 | 3406013.713 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vv% | vascular density (volume fraction) | 3 | Classified image:DUP_ROI5_01.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1808.804 | 961.631 | 140 | 4095 | 802938793 | |||
| SAv | vascular surface area | 4 | Classified image:DUP_ROI5_01.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 197.265 | 98.119 | 130 | 1784 | 316432013 | |||
| SSA | vasular specific surface area | |||||||||||||||||
| d | average vessel diameter | |||||||||||||||||
| R | morphological ratio for permeability | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| 1 | Classified image | 85 | 443906 | 8771902.172 | 275412 | 1436314.414 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 2 | Classified image | 155 | 1604094 | 3.169805239E7 | 762200 | 3406013.713 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 3 | Classified image:DUP_ROI5_02.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1775.085 | 1003.268 | 140 | 4095 | 787971037 | |||||
| 4 | Classified image:DUP_ROI5_02.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 209.723 | 105.607 | 132 | 2945 | 336415276 | |||||
| Sample | t (s) | Iv | Im | matrix norm | Vv | Vm | Vv% | SAv | SSA (µm-1) | d (µm) | R | P (μm/s) | P (cm/s) | |||||
| ROI6 (surrounding of 2) | 0 | 1486.297 | 179.904 | 4210594.457 | 3.62593601E7 | 0.10404248047942774 | 755778.326 | 0.018675047557454562 | 22.284811893375203 | 47.976184090783256 | ||||||||
| 720 | 1624.732 | 190.337 | 174.11936989546584 | 5.321432633160557E-4 | 5.321432633160557E-8 | |||||||||||||
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| Sample | t (s) | Iv | Im | matrix norm | Vv | Vm | Vv% | SAv | SSA (µm-1) | d (µm) | R | P (μm/s) | P (cm/s) | |||||
| ROI1 (spheroid 1) | 0 | 1385.412 | 213.719 | 9997185.377 | 3.047276918E7 | 0.24702734377720742 | 1501765.927 | 0.03710816934288459 | 26.627812489982006 | 20.291290827774922 | ||||||||
| 720 | 1533.627 | 241.712 | 218.35211909023513 | 6.733064701887489E-4 | 6.733064701887488E-8 | |||||||||||||
| Iv | vascular intensity | 9.664344720065564 | ||||||||||||||||
| Im | matrix intensity | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| Vv | vascular volume | 1 | Classified image | 85 | 505912 | 9997185.377 | 300606 | 1501765.927 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vm | matrix volume | 2 | Classified image | 155 | 1542088 | 3.047276918E7 | 741316 | 3293046.854 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vv% | vascular density (volume fraction) | 3 | Classified image:DUP_ROI1_01.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1385.412 | 713.047 | 132 | 4052 | 700896657 | |||
| SAv | vascular surface area | 4 | Classified image:DUP_ROI1_01.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 213.719 | 130.176 | 124 | 3059 | 329573609 | |||
| SSA | vasular specific surface area | |||||||||||||||||
| d | average vessel diameter | |||||||||||||||||
| R | morphological ratio for permeability | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| 1 | Classified image | 85 | 505912 | 9997185.377 | 300606 | 1501765.927 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 2 | Classified image | 155 | 1542088 | 3.047276918E7 | 741316 | 3293046.854 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 3 | Classified image:DUP_ROI1_02.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1533.627 | 767.201 | 132 | 4095 | 775880550 | |||||
| 4 | Classified image:DUP_ROI1_02.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 241.712 | 187.947 | 125 | 3223 | 372740830 | |||||
| Sample | t (s) | Iv | Im | matrix norm | Vv | Vm | Vv% | SAv | SSA (µm-1) | d (µm) | R | P (μm/s) | P (cm/s) | |||||
| ROI2 (surrounding of 1) | 0 | 1551.801 | 182.804 | 8163568.407 | 3.230638615E7 | 0.2017192382932381 | 1419569.792 | 0.03507712839164679 | 23.002936391027404 | 22.757870963486944 | ||||||||
| 720 | 1620.002 | 213.398 | 204.41408701841107 | 7.063710636498833E-4 | 7.063710636498834E-8 | |||||||||||||
| Iv | vascular intensity | 4.2099330741567 | ||||||||||||||||
| Im | matrix intensity | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| Vv | vascular volume | 1 | Classified image | 85 | 413121 | 8163568.407 | 266742 | 1419569.792 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vm | matrix volume | 2 | Classified image | 155 | 1634879 | 3.230638615E7 | 781548 | 3514287.286 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vv% | vascular density (volume fraction) | 3 | Classified image:DUP_ROI2_01.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1551.801 | 815.448 | 132 | 4095 | 641081612 | |||
| SAv | vascular surface area | 4 | Classified image:DUP_ROI2_01.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 182.804 | 73.544 | 127 | 2245 | 298861964 | |||
| SSA | vasular specific surface area | |||||||||||||||||
| d | average vessel diameter | |||||||||||||||||
| R | morphological ratio for permeability | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| 1 | Classified image | 85 | 413121 | 8163568.407 | 266742 | 1419569.792 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 2 | Classified image | 155 | 1634879 | 3.230638615E7 | 781548 | 3514287.286 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 3 | Classified image:DUP_ROI2_02.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1620.002 | 835.017 | 134 | 4095 | 669257029 | |||||
| 4 | Classified image:DUP_ROI2_02.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 213.398 | 98.419 | 127 | 2067 | 348879252 | |||||
| Sample | t (s) | Iv | Im | matrix norm | Vv | Vm | Vv% | SAv | SSA (µm-1) | d (µm) | R | P (μm/s) | P (cm/s) | |||||
| ROI3 (surrounding of 1) | 0 | 1689.994 | 187.498 | 1.045101007E7 | 3.001894449E7 | 0.25824121088412705 | 1645483.711 | 0.04065939111842679 | 25.40532002871951 | 18.243234065049947 | ||||||||
| 720 | 1772.825 | 198.131 | 188.87380379563692 | 1.7931301925972617E-4 | 1.793130192597262E-8 | |||||||||||||
| Iv | vascular intensity | 4.672260375389569 | ||||||||||||||||
| Im | matrix intensity | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| Vv | vascular volume | 1 | Classified image | 85 | 528878 | 1.045101007E7 | 319550 | 1645483.711 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vm | matrix volume | 2 | Classified image | 155 | 1519122 | 3.001894449E7 | 739398 | 3348818.158 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vv% | vascular density (volume fraction) | 3 | Classified image:DUP_ROI3_01.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1689.994 | 884.84 | 134 | 4095 | 893800714 | |||
| SAv | vascular surface area | 4 | Classified image:DUP_ROI3_01.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 187.498 | 103.561 | 127 | 2233 | 284831968 | |||
| SSA | vasular specific surface area | |||||||||||||||||
| d | average vessel diameter | |||||||||||||||||
| R | morphological ratio for permeability | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| 1 | Classified image | 85 | 528878 | 1.045101007E7 | 319550 | 1645483.711 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 2 | Classified image | 155 | 1519122 | 3.001894449E7 | 739398 | 3348818.158 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 3 | Classified image:DUP_ROI3_02.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1772.825 | 906.279 | 134 | 4095 | 937607920 | |||||
| 4 | Classified image:DUP_ROI3_02.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 198.131 | 127.689 | 127 | 2207 | 300985705 | |||||
| Sample | t (s) | Iv | Im | matrix norm | Vv | Vm | Vv% | SAv | SSA (µm-1) | d (µm) | R | P (μm/s) | P (cm/s) | |||||
| ROI4 (spheroid 2) | 0 | 1284.963 | 195.513 | 8396488.014 | 3.207346655E7 | 0.20747460936042378 | 1170247.428 | 0.02891645025569147 | 28.69987256746186 | 27.407423235968864 | ||||||||
| 720 | 1510.058 | 220.297 | 187.4586896735092 | 8.659639388379612E-4 | 8.659639388379612E-8 | |||||||||||||
| Iv | vascular intensity | 14.90638107940225 | ||||||||||||||||
| Im | matrix intensity | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| Vv | vascular volume | 1 | Classified image | 85 | 424908 | 8396488.014 | 238028 | 1170247.428 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vm | matrix volume | 2 | Classified image | 155 | 1623092 | 3.207346655E7 | 730682 | 3158531.331 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vv% | vascular density (volume fraction) | 3 | Classified image:DUP_ROI4_01.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1284.963 | 676.115 | 136 | 4095 | 545990913 | |||
| SAv | vascular surface area | 4 | Classified image:DUP_ROI4_01.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 195.513 | 100.821 | 127 | 4095 | 317335492 | |||
| SSA | vasular specific surface area | |||||||||||||||||
| d | average vessel diameter | |||||||||||||||||
| R | morphological ratio for permeability | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| 1 | Classified image | 85 | 424908 | 8396488.014 | 238028 | 1170247.428 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 2 | Classified image | 155 | 1623092 | 3.207346655E7 | 730682 | 3158531.331 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 3 | Classified image:DUP_ROI4_02.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1510.058 | 736.012 | 131 | 4095 | 641635757 | |||||
| 4 | Classified image:DUP_ROI4_02.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 220.297 | 163.082 | 126 | 3063 | 357562335 | |||||
| Sample | t (s) | Iv | Im | matrix norm | Vv | Vm | Vv% | SAv | SSA (µm-1) | d (µm) | R | P (μm/s) | P (cm/s) | |||||
| ROI5 (surrounding of 2) | 0 | 1605.279 | 188.836 | 6783677.33 | 3.368627723E7 | 0.16762255860561068 | 1119092.896 | 0.027652437670540347 | 24.247057073624745 | 30.101412805322642 | ||||||||
| 720 | 1807.33 | 236.355 | 209.93162180952012 | 0.0014025636313169739 | 1.402563631316974E-7 | Side leakage at 12 min | ||||||||||||
| Iv | vascular intensity | 11.179530024953936 | ||||||||||||||||
| Im | matrix intensity | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| Vv | vascular volume | 1 | Classified image | 85 | 343291 | 6783677.33 | 213688 | 1119092.896 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vm | matrix volume | 2 | Classified image | 155 | 1704709 | 3.368627723E7 | 777886 | 3401182.571 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vv% | vascular density (volume fraction) | 3 | Classified image:DUP_ROI5_01.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1605.279 | 813.106 | 136 | 4095 | 551077754 | |||
| SAv | vascular surface area | 4 | Classified image:DUP_ROI5_01.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 188.836 | 88.641 | 127 | 2627 | 321909919 | |||
| SSA | vasular specific surface area | |||||||||||||||||
| d | average vessel diameter | |||||||||||||||||
| R | morphological ratio for permeability | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| 1 | Classified image | 85 | 343291 | 6783677.33 | 213688 | 1119092.896 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 2 | Classified image | 155 | 1704709 | 3.368627723E7 | 777886 | 3401182.571 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 3 | Classified image:DUP_ROI5_02.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1807.33 | 842.96 | 134 | 4095 | 620440251 | |||||
| 4 | Classified image:DUP_ROI5_02.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 236.355 | 164.104 | 127 | 2952 | 402916841 | |||||
| Sample | t (s) | Iv | Im | matrix norm | Vv | Vm | Vv% | SAv | SSA (µm-1) | d (µm) | R | P (μm/s) | P (cm/s) | |||||
| ROI6 (surrounding of 2) | 0 | 1710.723 | 184.485 | 9585885.751 | 3.088406881E7 | 0.23686425781751944 | 1493138.897 | 0.03689499810901456 | 25.67982327768667 | 20.6839891935385 | ||||||||
| 720 | 1795.841 | 204.33 | 194.64531135551536 | 3.7353443705824714E-4 | 3.7353443705824716E-8 | |||||||||||||
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| Sample | t (s) | Iv | Im | matrix norm | Vv | Vm | Vv% | SAv | SSA (µm-1) | d (µm) | R | P (μm/s) | P (cm/s) | |||||
| ROI1 (spheroid 1) | 0 | 1461.611 | 173.92 | 5753096.499 | 3.471685806E7 | 0.14215722655711716 | 960352.973 | 0.02373002350669627 | 23.962424903119448 | 36.15010213541558 | ||||||||
| 720 | 1594.326 | 181.271 | 166.1816263304995 | 2.8662349982065216E-4 | 2.8662349982065217E-8 | |||||||||||||
| Iv | vascular intensity | 8.324207219853399 | ||||||||||||||||
| Im | matrix intensity | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| Vv | vascular volume | 1 | Classified image | 85 | 291138 | 5753096.499 | 183916 | 960352.973 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vm | matrix volume | 2 | Classified image | 155 | 1756862 | 3.471685806E7 | 793226 | 3437030.712 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vv% | vascular density (volume fraction) | 3 | Classified image:DUP_ROI1_01.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1461.611 | 786.998 | 130 | 3815 | 425530481 | |||
| SAv | vascular surface area | 4 | Classified image:DUP_ROI1_01.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 173.92 | 67.713 | 122 | 2094 | 305553329 | |||
| SSA | vasular specific surface area | |||||||||||||||||
| d | average vessel diameter | |||||||||||||||||
| R | morphological ratio for permeability | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| 1 | Classified image | 85 | 291138 | 5753096.499 | 183916 | 960352.973 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 2 | Classified image | 155 | 1756862 | 3.471685806E7 | 793226 | 3437030.712 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 3 | Classified image:DUP_ROI1_02.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1594.326 | 828.351 | 133 | 4095 | 464168959 | |||||
| 4 | Classified image:DUP_ROI1_02.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 181.271 | 82.18 | 123 | 3071 | 318467614 | |||||
| Sample | t (s) | Iv | Im | matrix norm | Vv | Vm | Vv% | SAv | SSA (µm-1) | d (µm) | R | P (μm/s) | P (cm/s) | |||||
| ROI2 (surrounding of 1) | 0 | 950.159 | 173.55 | 2560119.84 | 3.790983472E7 | 0.06325976561709289 | 528009.094 | 0.013046940619050698 | 19.394513231622483 | 71.79769278746551 | ||||||||
| 720 | 1113.296 | 185.901 | 158.6599684710984 | 0.0015859069214473622 | 1.5859069214473624E-7 | Not really connected networks | ||||||||||||
| Iv | vascular intensity | 14.653515327460088 | ||||||||||||||||
| Im | matrix intensity | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| Vv | vascular volume | 1 | Classified image | 85 | 129556 | 2560119.84 | 96084 | 528009.094 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vm | matrix volume | 2 | Classified image | 155 | 1918444 | 3.790983472E7 | 824796 | 3476844.197 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vv% | vascular density (volume fraction) | 3 | Classified image:DUP_ROI2_01.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 950.159 | 551.348 | 135 | 3921 | 123098804 | |||
| SAv | vascular surface area | 4 | Classified image:DUP_ROI2_01.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 173.55 | 60.226 | 124 | 1433 | 332946620 | |||
| SSA | vasular specific surface area | |||||||||||||||||
| d | average vessel diameter | |||||||||||||||||
| R | morphological ratio for permeability | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| 1 | Classified image | 85 | 129556 | 2560119.84 | 96084 | 528009.094 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 2 | Classified image | 155 | 1918444 | 3.790983472E7 | 824796 | 3476844.197 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 3 | Classified image:DUP_ROI2_02.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1113.296 | 632.79 | 132 | 4095 | 144234169 | |||||
| 4 | Classified image:DUP_ROI2_02.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 185.901 | 89.971 | 125 | 1573 | 356640353 | |||||
| Sample | t (s) | Iv | Im | matrix norm | Vv | Vm | Vv% | SAv | SSA (µm-1) | d (µm) | R | P (μm/s) | P (cm/s) | |||||
| ROI3 (surrounding of 1) | 0 | 1520.065 | 183.467 | 6610099.165 | 3.38598554E7 | 0.16333349607258202 | 1106740.402 | 0.02734721137930687 | 23.89033292018556 | 30.594216438481478 | ||||||||
| 720 | 1551.807 | 186.374 | 182.56174531368916 | 9.241682904685495E-5 | 9.241682904685496E-9 | |||||||||||||
| Iv | vascular intensity | 2.0454863265857135 | ||||||||||||||||
| Im | matrix intensity | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| Vv | vascular volume | 1 | Classified image | 85 | 334507 | 6610099.165 | 212020 | 1106740.402 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vm | matrix volume | 2 | Classified image | 155 | 1713493 | 3.38598554E7 | 785596 | 3437821.093 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vv% | vascular density (volume fraction) | 3 | Classified image:DUP_ROI3_01.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1520.065 | 782.097 | 134 | 4095 | 508472374 | |||
| SAv | vascular surface area | 4 | Classified image:DUP_ROI3_01.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 183.467 | 72.791 | 127 | 1763 | 314369593 | |||
| SSA | vasular specific surface area | |||||||||||||||||
| d | average vessel diameter | |||||||||||||||||
| R | morphological ratio for permeability | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| 1 | Classified image | 85 | 334507 | 6610099.165 | 212020 | 1106740.402 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 2 | Classified image | 155 | 1713493 | 3.38598554E7 | 785596 | 3437821.093 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 3 | Classified image:DUP_ROI3_02.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1551.807 | 858.792 | 134 | 4095 | 519090181 | |||||
| 4 | Classified image:DUP_ROI3_02.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 186.374 | 70.998 | 126 | 2231 | 319350452 | |||||
| Sample | t (s) | Iv | Im | matrix norm | Vv | Vm | Vv% | SAv | SSA (µm-1) | d (µm) | R | P (μm/s) | P (cm/s) | |||||
| ROI4 (spheroid 2) | 0 | 1569.888 | 221.574 | 7869785.783 | 3.260016878E7 | 0.19445996092605003 | 1282860.821 | 0.0316990921994478 | 24.538237209132134 | 25.41208543151853 | ||||||||
| 720 | 1755.104 | 293.054 | 262.12803227159185 | 0.0018711185750056737 | 1.8711185750056738E-7 | Side leakage already at t0 | ||||||||||||
| Iv | vascular intensity | 10.552992871077732 | ||||||||||||||||
| Im | matrix intensity | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| Vv | vascular volume | 1 | Classified image | 85 | 398254 | 7869785.783 | 245714 | 1282860.821 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vm | matrix volume | 2 | Classified image | 155 | 1649746 | 3.260016878E7 | 765050 | 3382583.686 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vv% | vascular density (volume fraction) | 3 | Classified image:DUP_ROI4_01.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1569.888 | 729.629 | 137 | 3847 | 625214354 | |||
| SAv | vascular surface area | 4 | Classified image:DUP_ROI4_01.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 221.574 | 116.288 | 126 | 1666 | 365540162 | |||
| SSA | vasular specific surface area | |||||||||||||||||
| d | average vessel diameter | |||||||||||||||||
| R | morphological ratio for permeability | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| 1 | Classified image | 85 | 398254 | 7869785.783 | 245714 | 1282860.821 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 2 | Classified image | 155 | 1649746 | 3.260016878E7 | 765050 | 3382583.686 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 3 | Classified image:DUP_ROI4_02.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1755.104 | 782.14 | 138 | 4095 | 698977091 | |||||
| 4 | Classified image:DUP_ROI4_02.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 293.054 | 208.674 | 126 | 2167 | 483464566 | |||||
| Sample | t (s) | Iv | Im | matrix norm | Vv | Vm | Vv% | SAv | SSA (µm-1) | d (µm) | R | P (μm/s) | P (cm/s) | |||||
| ROI5 (surrounding of 2) | 0 | 954.494 | 198.605 | 4888031.46 | 3.55819231E7 | 0.12078173828322676 | 846757.81 | 0.020923122331274493 | 23.090576324297498 | 42.021369841277284 | ||||||||
| 720 | 1171.685 | 252.469 | 205.66973690539695 | 0.004158898155994979 | 4.1588981559949796E-7 | Side leakage already at t0 | ||||||||||||
| Iv | vascular intensity | 18.53663740681155 | ||||||||||||||||
| Im | matrix intensity | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| Vv | vascular volume | 1 | Classified image | 85 | 247361 | 4888031.46 | 159658 | 846757.81 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vm | matrix volume | 2 | Classified image | 155 | 1800639 | 3.55819231E7 | 794004 | 3407220.175 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vv% | vascular density (volume fraction) | 3 | Classified image:DUP_ROI5_01.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 954.494 | 503.968 | 134 | 3885 | 236104563 | |||
| SAv | vascular surface area | 4 | Classified image:DUP_ROI5_01.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 198.605 | 86.444 | 126 | 1668 | 357615378 | |||
| SSA | vasular specific surface area | |||||||||||||||||
| d | average vessel diameter | |||||||||||||||||
| R | morphological ratio for permeability | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| 1 | Classified image | 85 | 247361 | 4888031.46 | 159658 | 846757.81 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 2 | Classified image | 155 | 1800639 | 3.55819231E7 | 794004 | 3407220.175 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 3 | Classified image:DUP_ROI5_02.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1171.685 | 570.541 | 138 | 3748 | 289829061 | |||||
| 4 | Classified image:DUP_ROI5_02.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 252.469 | 154.529 | 127 | 2952 | 454605414 | |||||
| Sample | t (s) | Iv | Im | matrix norm | Vv | Vm | Vv% | SAv | SSA (µm-1) | d (µm) | R | P (μm/s) | P (cm/s) | |||||
| ROI6 (surrounding of 2) | 0 | 1084.359 | 187.42 | 6901885.957 | 3.35680686E7 | 0.17054345705476448 | 1240351.863 | 0.03064870906274489 | 22.257832355108096 | 27.063343557053216 | ||||||||
| 720 | 1327.707 | 227.95 | 186.17031773576545 | 0.0016984886535194935 | 1.6984886535194935E-7 | |||||||||||||
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| Sample | t (s) | Iv | Im | matrix norm | Vv | Vm | Vv% | SAv | SSA (µm-1) | d (µm) | R | P (μm/s) | P (cm/s) | |||||
| ROI1 (spheroid 1) | 0 | 1630.4 | 186.528 | 1.609605496E7 | 2.437389961E7 | 0.39772851566114326 | 2306980.612 | 0.05700477394926812 | 27.908435599804683 | 10.565281512647578 | ||||||||
| 720 | 1660.503 | 191.599 | 188.1255316009667 | 5.153633054291578E-5 | 5.153633054291578E-9 | |||||||||||||
| Iv | vascular intensity | 1.8128844091218046 | ||||||||||||||||
| Im | matrix intensity | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| Vv | vascular volume | 1 | Classified image | 85 | 814548 | 1.609605496E7 | 458140 | 2306980.612 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vm | matrix volume | 2 | Classified image | 155 | 1233452 | 2.437389961E7 | 644728 | 3061300.986 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vv% | vascular density (volume fraction) | 3 | Classified image:DUP_ROI1_01.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1630.4 | 883.586 | 127 | 4095 | 1328039163 | |||
| SAv | vascular surface area | 4 | Classified image:DUP_ROI1_01.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 186.528 | 103.126 | 119 | 2721 | 230073073 | |||
| SSA | vasular specific surface area | |||||||||||||||||
| d | average vessel diameter | |||||||||||||||||
| R | morphological ratio for permeability | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| 1 | Classified image | 85 | 814548 | 1.609605496E7 | 458140 | 2306980.612 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 2 | Classified image | 155 | 1233452 | 2.437389961E7 | 644728 | 3061300.986 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 3 | Classified image:DUP_ROI1_02.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1660.503 | 963.466 | 130 | 4095 | 1352559377 | |||||
| 4 | Classified image:DUP_ROI1_02.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 191.599 | 104.21 | 123 | 2547 | 236328665 | |||||
| Sample | t (s) | Iv | Im | matrix norm | Vv | Vm | Vv% | SAv | SSA (µm-1) | d (µm) | R | P (μm/s) | P (cm/s) | |||||
| ROI2 (surrounding of 1) | 0 | 1459.735 | 173.593 | 1.399199277E7 | 2.647796179E7 | 0.3457377929410751 | 2047686.201 | 0.05059768965058111 | 27.332298792982883 | 12.930673546107469 | ||||||||
| 720 | 1353.957 | 174.131 | 187.73499844160483 | 1.9747426923348278E-4 | 1.9747426923348278E-8 | |||||||||||||
| Iv | vascular intensity | -7.812508078173811 | ||||||||||||||||
| Im | matrix intensity | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| Vv | vascular volume | 1 | Classified image | 85 | 708071 | 1.399199277E7 | 397104 | 2047686.201 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vm | matrix volume | 2 | Classified image | 155 | 1339929 | 2.647796179E7 | 650666 | 3063248.463 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vv% | vascular density (volume fraction) | 3 | Classified image:DUP_ROI2_01.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1459.735 | 909.39 | 127 | 4095 | 1033596321 | |||
| SAv | vascular surface area | 4 | Classified image:DUP_ROI2_01.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 173.593 | 78.487 | 123 | 2375 | 232602307 | |||
| SSA | vasular specific surface area | |||||||||||||||||
| d | average vessel diameter | |||||||||||||||||
| R | morphological ratio for permeability | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| 1 | Classified image | 85 | 708071 | 1.399199277E7 | 397104 | 2047686.201 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 2 | Classified image | 155 | 1339929 | 2.647796179E7 | 650666 | 3063248.463 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 3 | Classified image:DUP_ROI2_02.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1353.957 | 954.196 | 132 | 4095 | 958697757 | |||||
| 4 | Classified image:DUP_ROI2_02.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 174.131 | 67.917 | 123 | 1756 | 233323702 | |||||
| Sample | t (s) | Iv | Im | matrix norm | Vv | Vm | Vv% | SAv | SSA (µm-1) | d (µm) | R | P (μm/s) | P (cm/s) | |||||
| ROI3 (surrounding of 1) | 0 | 1510.156 | 183.883 | 1.231092856E7 | 28159026 | 0.30419921875 | 1815249.511 | 0.04485425127692557 | 27.127793695353873 | 15.512482349871297 | ||||||||
| 720 | 1520.753 | 187.739 | 186.43078611977091 | 6.264016611158534E-5 | 6.264016611158534E-9 | |||||||||||||
| Iv | vascular intensity | 0.6968258487735998 | ||||||||||||||||
| Im | matrix intensity | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| Vv | vascular volume | 1 | Classified image | 85 | 623000 | 1.231092856E7 | 357348 | 1815249.511 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vm | matrix volume | 2 | Classified image | 155 | 1425000 | 28159026 | 682336 | 3134354.499 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vv% | vascular density (volume fraction) | 3 | Classified image:DUP_ROI3_01.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1510.156 | 903.35 | 129 | 4095 | 940826934 | |||
| SAv | vascular surface area | 4 | Classified image:DUP_ROI3_01.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 183.883 | 93.796 | 124 | 3159 | 262033091 | |||
| SSA | vasular specific surface area | |||||||||||||||||
| d | average vessel diameter | |||||||||||||||||
| R | morphological ratio for permeability | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| 1 | Classified image | 85 | 623000 | 1.231092856E7 | 357348 | 1815249.511 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 2 | Classified image | 155 | 1425000 | 28159026 | 682336 | 3134354.499 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 3 | Classified image:DUP_ROI3_02.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1520.753 | 958.762 | 131 | 4095 | 947429003 | |||||
| 4 | Classified image:DUP_ROI3_02.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 187.739 | 93.115 | 124 | 3522 | 267528224 | |||||
| Sample | t (s) | Iv | Im | matrix norm | Vv | Vm | Vv% | SAv | SSA (µm-1) | d (µm) | R | P (μm/s) | P (cm/s) | |||||
| ROI4 (spheroid 2) | 0 | 1893.543 | 215.773 | 1.433171907E7 | 2.613823549E7 | 0.3541323242345642 | 2174488.666 | 0.05373093915329566 | 26.363382424730467 | 12.02040548598564 | ||||||||
| 720 | 1887.696 | 221.235 | 221.92025919692577 | 6.116961152676058E-5 | 6.116961152676059E-9 | |||||||||||||
| Iv | vascular intensity | -0.30974267042998344 | ||||||||||||||||
| Im | matrix intensity | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| Vv | vascular volume | 1 | Classified image | 85 | 725263 | 1.433171907E7 | 431952 | 2174488.666 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vm | matrix volume | 2 | Classified image | 155 | 1322737 | 2.613823549E7 | 703618 | 3269037.46 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vv% | vascular density (volume fraction) | 3 | Classified image:DUP_ROI4_01.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1893.543 | 960.424 | 132 | 4095 | 1373316916 | |||
| SAv | vascular surface area | 4 | Classified image:DUP_ROI4_01.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 215.773 | 130.033 | 126 | 2964 | 285411297 | |||
| SSA | vasular specific surface area | |||||||||||||||||
| d | average vessel diameter | |||||||||||||||||
| R | morphological ratio for permeability | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| 1 | Classified image | 85 | 725263 | 1.433171907E7 | 431952 | 2174488.666 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 2 | Classified image | 155 | 1322737 | 2.613823549E7 | 703618 | 3269037.46 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 3 | Classified image:DUP_ROI4_02.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1887.696 | 999.664 | 133 | 4095 | 1369075959 | |||||
| 4 | Classified image:DUP_ROI4_02.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 221.235 | 131.808 | 127 | 3661 | 292636119 | |||||
| Sample | t (s) | Iv | Im | matrix norm | Vv | Vm | Vv% | SAv | SSA (µm-1) | d (µm) | R | P (μm/s) | P (cm/s) | |||||
| ROI5 (surrounding of 2) | 0 | 1663.128 | 191.987 | 1.395899237E7 | 2.651096219E7 | 0.34492236331287834 | 1981948.337 | 0.048973327461032855 | 28.172262837343574 | 13.376212535453188 | ||||||||
| 720 | 1641.812 | 196.762 | 199.31660356727812 | 9.256074698758773E-5 | 9.256074698758773E-9 | |||||||||||||
| Iv | vascular intensity | -1.298321610513264 | ||||||||||||||||
| Im | matrix intensity | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| Vv | vascular volume | 1 | Classified image | 85 | 706401 | 1.395899237E7 | 392164 | 1981948.337 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vm | matrix volume | 2 | Classified image | 155 | 1341599 | 2.651096219E7 | 647148 | 3015908.632 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Vv% | vascular density (volume fraction) | 3 | Classified image:DUP_ROI5_01.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1663.128 | 1031.41 | 130 | 4095 | 1174834981 | |||
| SAv | vascular surface area | 4 | Classified image:DUP_ROI5_01.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 191.987 | 113.367 | 125 | 1941 | 257570211 | |||
| SSA | vasular specific surface area | |||||||||||||||||
| d | average vessel diameter | |||||||||||||||||
| R | morphological ratio for permeability | Label | Value | Volume(pix) | Volume(unit) | Surface(pix) | Surface(unit) | Channel | Frame | Average | StandardDeviation | Minimum | Maximum | IntegratedDensity | ||||
| 1 | Classified image | 85 | 706401 | 1.395899237E7 | 392164 | 1981948.337 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 2 | Classified image | 155 | 1341599 | 2.651096219E7 | 647148 | 3015908.632 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |||||
| 3 | Classified image:DUP_ROI5_02.oib | 85 | 0 | 0 | 0 | 0 | 1 | 1 | 1641.812 | 1046.282 | 133 | 4095 | 1159777989 | |||||
| 4 | Classified image:DUP_ROI5_02.oib | 155 | 0 | 0 | 0 | 0 | 1 | 1 | 196.762 | 113.166 | 125 | 2715 | 263975065 | |||||
| Sample | t (s) | Iv | Im | matrix norm | Vv | Vm | Vv% | SAv | SSA (µm-1) | d (µm) | R | P (μm/s) | P (cm/s) | |||||
| ROI6 (surrounding of 2) | 0 | 1737.338 | 191.302 | 1.111346845E7 | 2.935648611E7 | 0.2746103515763374 | 1785294.439 | 0.04411407075718742 | 24.900023676150596 | 16.443498320895177 | ||||||||
| 720 | 1706.544 | 195.689 | 199.220140753476 | 1.1696753484430344E-4 | 1.1696753484430345E-8 | |||||||||||||
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| P (cm/s) | Spheroid 1 | Surrounding 1 | Surrounding 1 | Spheroid 2 | Surrounding 2 | Surrounding 2 | ||||
| P3 A | 8.484714614401623E-8 | 3.644279777275044E-8 | 1.98430485199699E-7 | 4.005521394679165E-7 | 3.127231916601748E-8 | 5.321432633160557E-8 | Red values are not usable either due to a leakage from the side channel or because the normalized difference in Iv is above 10%. | |||
| P3 B | 6.733064701887488E-8 | 7.063710636498834E-8 | 1.793130192597262E-8 | 8.659639388379612E-8 | 1.402563631316974E-7 | 3.7353443705824716E-8 | ||||
| P4 A | 2.8662349982065217E-8 | 1.5859069214473624E-7 | 9.241682904685496E-9 | 1.8711185750056738E-7 | 4.1588981559949796E-7 | 1.6984886535194935E-7 | ||||
| P4 B | 5.153633054291578E-9 | 1.9747426923348278E-8 | 6.264016611158534E-9 | 6.116961152676059E-9 | 9.256074698758773E-9 | 1.1696753484430345E-8 | ||||
