Figure 6B.xlsx

Selected Cell

Cell:

Value:

Sheet1 Sheet2

no inhibitor								no inhibitor				200 uM iLig4
2014-07-18T0:0:0+0000	Xrcc5 WT	Xrcc5 KD	Xrcc6 WT	Xrcc6 KD		Average	Xrcc5 WT	Xrcc5 KD	Xrcc6 WT	Xrcc6 KD	Average	Xrcc5 WT	Xrcc5 KD	Xrcc6 WT	Xrcc6 KD
-30	43.47	40.25	43.47	40.25	0.33333333333333365	-30	40.78666666666667	41.86	43.47	42.93333333333334	-30	28.98	28.98	27.370000000000005	30.590000000000003
0	83.72	83.72	77.28	83.72	0.2113248654051867	0	99.28333333333335	96.60000000000001	96.33166666666666	96.06333333333333	0	100.35666666666667	103.04	101.69833333333334	99.82000000000001
30	74.06	57.96	50.715	54.74	0.07573593128807171	30	67.61999999999999	57.96000000000001	57.96	56.88666666666666	30	96.6	96.6	84.9275	87.3425
60	38.64	38.64	37.03	30.59	0.09175170953613682	60	45.080000000000005	40.78666666666667	40.25	39.71333333333333	60	85.86666666666667	82.64666666666668	80.76833333333333	82.64666666666668


2014-07-20T0:0:0+0000	Xrcc5 WT	Xrcc5 KD	Xrcc6 WT	Xrcc6 KD		stdev	Xrcc5 WT	Xrcc5 KD	Xrcc6 WT	Xrcc6 KD	stdev	Xrcc5 WT	Xrcc5 KD	Xrcc6 WT	Xrcc6 KD
-30	41.86	45.08	48.3	48.3		-30	3.3514822591404725	2.7886018001858917	4.829999999999998	4.647669666976486	-30	14.3099930118781	13.178417962714649	12.778978832441949	12.155233440785892
0	119.14	111.09	115.92	106.26		0	18.096094422093685	13.755846029961146	19.325589469233126	11.422304204202119	0	21.439816541503642	22.36683482301417	16.699304127218348	22.825689474800058
30	66.01	64.4	61.18	57.96		30	5.804937553497024	6.440000000000001	6.287250989104854	1.8590678667905944	30	22.76883835420687	34.153257531310295	38.137804243296465	40.41468807871713
60	48.3	41.86	43.47	54.74		60	5.577203600371701	1.8590678667905944	3.219999999999999	13.11268978254782	60	23.460375813983276	29.918865843031735	31.305427777516968	27.76180349569046


2014-07-24T0:0:0+0000	Xrcc5 WT	Xrcc5 KD	Xrcc6 WT	Xrcc6 KD
-30	37.03	40.25	38.64	40.25
0	94.99	94.99	95.795	98.21
30	62.79	51.52	61.985	57.96
60	48.3	41.86	40.25	33.81


	43.47	41.86	37.03
	83.72	119.14	94.99											Xrcc5 WT
	74.06	66.01	62.79											exp1	2	3
	38.64	48.3	48.3											43.47	41.86	37.03
														83.72	119.14	94.99
	40.25	45.08	40.25											74.06	66.01	62.79
	83.72	111.09	94.99											38.64	48.3	48.3
	57.96	64.4	51.52
	38.64	41.86	41.86											Xrcc5 WT + iLig4
														exp1	2	3	p-values
														45.08	24.15	17.71	0.11060422102736622
														114.31	111.09	75.67	0.47521669118468257
200 uM iLig 4 Inhibitors (scr7)														112.7	80.5		0.15661647613780824
2014-07-28T0:0:0+0000	Xrcc5 WT	Xrcc5 KD	Xrcc6 WT	Xrcc6 KD										107.87	88.55	61.18	0.04382730590662544
-30	45.08	43.47	41.86	43.47
0	114.31	114.31	104.65	107.87
30	112.7	120.75	111.895	115.92										Xrcc6 WT
60	107.87	115.92	116.725	112.7										exp1	2	3
														43.47	48.3	38.64
2014-07-31T0:0:0+0000	Xrcc5 WT	Xrcc5 KD	Xrcc6 WT	Xrcc6 KD										77.28	115.92	95.795
-30	24.15	25.76	22.54	28.98										50.715	61.18	61.985
0	111.09	117.53	116.725	117.53										37.03	43.47	40.25
30	80.5	72.45	57.96	58.765
60	88.55	74.06	66.01	77.28										Xrcc6 WT + iLig4
														exp1	2	3	p-values
2014-08-04T0:0:0+0000	Xrcc5 WT	Xrcc5 KD	Xrcc6 WT	Xrcc6 KD										41.86	22.54	17.71	0.08040932085165553
-30	17.71	17.71	17.71	19.32										104.65	116.725	83.72	0.36734671394910867
0	75.67	77.28	83.72	74.06										111.895	57.96		0.24909750670263286
30														116.725	66.01	59.57	0.0764346661537741
60	61.18	57.96	59.57	57.96

Xrcc5 WT
	Exp 1	2	3	Average n=3	stdev	std error		For protocol See:
-30	43.47	41.86	37.03	40.78666666666667	3.3514822591404725	1.934979184499007		https://pubmed.ncbi.nlm.nih.gov/32452708/
0	83.72	119.14	94.99	99.28333333333335	18.096094422093685	10.447784985876675
30	74.06	66.01	62.79	67.61999999999999	5.804937553497024	3.3514822591404747
60	38.64	48.3	48.3	45.080000000000005	5.577203600371701	3.219999999999952

Xrcc5 WT + 200 uM Scr7
	Exp 1	2	3	Average n=3	stdev	std error	1-tailed, unequal	2-tailed, paired	2-tailed, unequal
-30	45.08	24.15	17.71	28.98	14.3099930118781	8.261878317509485	0.14359264992396506	0.22120844205473245	0.2871852998479301
0	114.31	111.09	75.67	100.35666666666667	21.439816541503642	12.37828385161332	0.47521669118468257	0.9498430137424492	0.9504333823693651
30	112.7	80.5	68.17	87.12333333333333	22.991990634421683	13.274431981988714	0.13850669813169952	0.18828927991051425	0.27701339626339905
60	107.87	88.55	61.18	85.86666666666667	23.460375813983276	13.544854291493031	0.04382730590662544	0.12902205871479666	0.08765461181325088


normalized
Xrcc5 WT
	Exp 1	2	3	Average n=3	stdev	std error
-30
0	1	1	1	1	0	0
30	0.7600000000000001	0.31250000000000006	0.4444444444444445	0.5056481481481482	0.2299423460571977	0.1327572753942172
60	-0.11999999999999995	0.0833333333333333	0.1944444444444444	0.05259259259259258	0.15946025215225546	0.09206441950515029


normalized
Xrcc5 WT + 200uM Scr7
	Exp 1	2	3	Average n=3	stdev	std error	1-tailed, unequal	2-tailed, paired	2-tailed, unequal
-30
0	1	1	1	1	0	0
30	0.9767441860465116	0.6481481481481481	0.870600414078675	0.8318309160911115	0.16769360307203632	0.09681794687501843	0.062339792226236895	0.03286421198367086	0.12467958445247379
60	0.9069767441860466	0.7407407407407408	0.75	0.7992391616422624	0.09341827171271991	0.053935064320568445	0.002349013346037433	0.03487833610779972	0.004698026692074866