Selected Cell
Cell:
Value:
Metabolome phenol
metabolome glucose
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| Normalized peak area | ||||||||||||||||||
| Cultivation 1 | Cultivation 2 | Cultivation 3 | Cultivation 4 | |||||||||||||||
| Compound | Phenol_1 | Phenol_2 | Phenol_3 | Phenol_4 | Phenol_5 | Phenol_6 | Phenol_7 | Mean phenol | Fold change phenol | p-value | ||||||||
| (4-hydroxyphenyl)acetate | 1783.1619 | 1922.2128 | 1747.3596 | 1824.8031 | 2772.8143 | 2349.8946 | 1565.1844 | 1995.0615285714284 | 0.201133594496527 | 0.00762545249175134 | ||||||||
| 1,3-diaminopropane | 42000.6361 | 33668.7601 | 38075.876 | 21292.6953 | 30965.8282 | 42557.9218 | 33510.5822 | 34581.757099999995 | 2.2031927950668115 | 0.00762545249175134 | ||||||||
| 1,6-anhydro-glucose | 2235.3864 | 2478.4583 | 2082.6904 | 2216.3398 | 2487.499 | 2249.4589 | 2696.7476 | 2349.5114857142858 | 0.7970500082131526 | 0.0312564760425063 | ||||||||
| 1-O-methyl-alpha-glucopyranoside | 417836.5933 | 702830.8134 | 340991.2259 | 815038.7917 | 473309.2437 | 476162.8091 | 478198.4873 | 529195.4234857144 | 2.981952910440151 | 0.00762545249175134 | ||||||||
| 2-aminoadipic-acid | 74044.4781 | 89156.5092 | 51747.4582 | 51916.2665 | 163125.4967 | 21615.1446 | 106954.4321 | 79794.25505714284 | 10.674510830544113 | 0.00762545249175134 | ||||||||
| 2-hydroxy-glutarate | 3615.8361 | 4145.9905 | 2733.0241 | 2832.083 | 10743.5708 | 7500.3026 | 5604.5211 | 5310.761171428572 | 0.7497154566740047 | 0.583418643852968 | ||||||||
| 2-isopropylmalic acid | 3139.7285 | 3296.3922 | 3026.8303 | 3285.8137 | 9597.6115 | 8179.9103 | 9245.0388 | 5681.617899999999 | 0.8046925328262095 | 0.861758769271743 | ||||||||
| 2-methyl-malate | 6125.1136 | 6992.9481 | 5711.0322 | 6196.5387 | 21914.7122 | 19303.4707 | 9472.8138 | 10816.66132857143 | 0.5271826036765421 | 0.194634608254005 | ||||||||
| alanine | 364812.2074 | 165834.7863 | 400869.8775 | 147369.6862 | 176905.8475 | 183243.5118 | 156345.4611 | 227911.62539999996 | 0.4683561158328491 | 0.0479859246049236 | ||||||||
| trehalose | 1964025.212 | 2378341.3833 | 1961140.796 | 1926101.6316 | 2775105.3975 | 2404076.3299 | 1612168.48 | 2145851.318614286 | 0.9209317877188028 | 1 | ||||||||
| aspartate | 19677.7863 | 24688.5382 | 20044.7808 | 17553.7515 | 12998.119 | 8190.0134 | 20016.7136 | 17595.67182857143 | 3.3972907882769268 | 0.00762545249175134 | ||||||||
| beta-Alanine | 12786.3919 | 13505.4692 | 11242.2788 | 10363.1526 | 13076.4578 | 13525.6193 | 8766.1677 | 11895.076757142859 | 9.59371412169975 | 0.00762545249175134 | ||||||||
| citrate | 2184.8055 | 8379.6003 | 4751.7625 | 5992.1426 | 24417.1347 | ND | 48691.3119 | 9145.08912 | 4.007926217361212 | 1 | ||||||||
| fumarate | 9969.425 | 13330.2662 | 6195.8156 | 6897.337 | 16988.4099 | 17606.5394 | 18304.787 | 12756.082871428573 | 5.274427445418992 | 0.00762545249175134 | ||||||||
| gluconic-acid | 756.2882 | 1734.3807 | 555.221 | 1268.6295 | 969.3561 | 10408.7373 | 1282.9285 | 1094.4673333333333 | 0.10486126107347689 | 0.00762545249175134 | ||||||||
| glucose | 149314.4238 | 225997.0236 | 116454.7696 | 205219.3961 | 152184.715 | 335704.2107 | 167396.0231 | 193181.50884285715 | 0.24289969656440163 | 0.00762545249175134 | ||||||||
| glutamate | 642119.6469 | 388124.2431 | 595019.5734 | 318894.8752 | 651538.4952 | 192556.3952 | 514903.2318 | 471879.4944000001 | 1.586337765898359 | 0.298447860466645 | ||||||||
| glycerate | 5920.4134 | 6426.7662 | 3769.3385 | 4158.837 | 3557.1078 | 4332.2096 | 4376.1721 | 4648.692085714286 | 1.5065329556577352 | 0.00762545249175134 | ||||||||
| glycine | 187199.7332 | 224018.2077 | 256830.2454 | 241289.9822 | 199422.9363 | 136630.3965 | 191986.9894 | 205339.78438571427 | 1.7455780624512993 | 0.0147555523839366 | ||||||||
| isoleucine | 40020.5127 | 36994.4595 | 38207.269 | 38796.1308 | 46064.9405 | 43708.1191 | 34025.976 | 39688.20108571428 | 0.6682403101422214 | 0.0147555523839366 | ||||||||
| lysine | 32445.4215 | 46681.5313 | 37179.0998 | 42995.8122 | 46757.2753 | 51836.5674 | 39181.3376 | 42439.57787142857 | 8.367097677385875 | 0.00762545249175134 | ||||||||
| malate | 2619.5537 | 2920.649 | 2107.3365 | 1820.2703 | 10520.7069 | 6131.0136 | 5991.8856 | 4587.345085714286 | 2.162573425163003 | 0.245548636531663 | ||||||||
| myo-inositol | 23331.6591 | 30544.9393 | 21502.9237 | 25318.2487 | 17816.216 | 17756.184 | 26811.112 | 23297.32611428571 | 1.6923764907173138 | 0.00762545249175134 | ||||||||
| myoinositol-2-phosphate | 3617.3798 | 3719.1603 | 3911.9469 | 4131.8958 | 3211.0751 | ND | 4108.6221 | 3242.8685714285716 | 0.8795197575924317 | 1 | ||||||||
| NA168015 | 2522.0453 | 3143.3949 | 2523.5594 | 2314.0346 | 4008.2009 | 2945.5978 | 3206.5671 | 2951.914285714286 | 0.6937521421584688 | 0.115272058085891 | ||||||||
| NA228 | 12630.2465 | 13331.1693 | 11159.508 | 11744.2429 | 14328.9502 | 12934.7847 | 11513.7963 | 12520.385414285714 | 0.8796623590747285 | 0.0358898294385211 | ||||||||
| NA321 | 2958.285 | 3901.5982 | 2009.7996 | 3950.0696 | 2101.885 | 5592.2902 | 2580.3673 | 3299.1849857142856 | 0.3802847216203486 | 0.298447860466645 | ||||||||
| NA547 | 46097.6454 | 50567.8458 | 38397.9422 | 42676.4153 | 60336.2211 | 55388.0683 | 14187.0125 | 43950.16437142857 | 0.4753346120963729 | 0.00762545249175134 | ||||||||
| Nicotinamide | 114867.8518 | 10219.4344 | 107742.1917 | 6765.9913 | 39709.4317 | 34087.2234 | 26076.1 | 48495.460614285716 | 0.8614306701233969 | 1 | ||||||||
| nicotinic acid | 3980.9592 | 4675.0449 | 4330.1334 | 3364.9239 | 5164.5306 | 4930.5016 | 4212.0627 | 4379.7366142857145 | 0.9245939348561563 | 1 | ||||||||
| putrescine | 1648797.9157 | 1730727.8325 | 1690849.1769 | 1298709.6419 | 1502887.6039 | 1623329.7543 | 1454863.7802 | 1564309.3864857145 | 3.1808229047935384 | 0.00762545249175134 | ||||||||
| pyroglutamate | 114357.4538 | 38726.7228 | 108026.6948 | 37658.4952 | 45471.8824 | ND | 50470.2957 | 56387.36352857143 | 0.8474524322700853 | 1 | ||||||||
| pyruvate | ND | 4893.3569 | ND | 4172.7258 | 11380.4182 | 10217.612 | 5544.0475 | 5172.594342857143 | 0.30233976331218376 | 0.00762545249175134 | ||||||||
| serine | 4216.3079 | 5905.3244 | 4314.9687 | 6099.9518 | 4201.1162 | 4174.7729 | 5852.7113 | 4966.450457142857 | 1.0703974361923208 | 1 | ||||||||
| similar to Inositol (6TMS)317 | 44360.2556 | 51532.915 | 43134.1676 | 46079.6958 | 50430.375 | 47987.446 | 50346.1201 | 47695.853585714285 | 9.552286239650225 | 0.00762545249175134 | ||||||||
| spermidine | 617053.0645 | 919818.5578 | 497889.332 | 519758.9201 | 471655.8607 | 474379.8284 | 923918.579 | 632067.7346428571 | 27.9768389099048 | 0.00762545249175134 | ||||||||
| succinate | 3468.6349 | 5251.9846 | 2555.3828 | 2930.2917 | 6428.6045 | 6093.1531 | 5888.5097 | 4659.508757142857 | 2.086260349832088 | 0.00762545249175134 | ||||||||
| succinic-acid-methylester | 2896.3774 | 2195.8092 | 2506.5366 | 2130.7252 | 3580.0011 | 2980.2539 | 3446.7991 | 2819.5003571428574 | 0.5770516058486662 | 0.00762545249175134 | ||||||||
| threonine | 5277.2587 | 7276.5918 | 4471.1241 | 5952.2032 | 5779.1363 | 4470.0494 | 5193.0503 | 5488.487685714287 | 2.6121156607647955 | 0.00762545249175134 | ||||||||
| Unknown_1411.4-pae-bth_025 | 31269.805 | 28584.1547 | 53533.5083 | 37734.9512 | 63404.22 | 64982.3858 | 28199.5043 | 43958.36132857144 | 0.3660338267391693 | 0.00762545249175134 | ||||||||
| Unknown_1586.9-pae-bth_039 | 3124.5068 | 3695.7538 | 1922.1071 | 3247.9803 | 2713.4105 | 2334.8741 | 3407.9892 | 2920.945971428571 | 1.5233167143463826 | 0.0275461426720885 | ||||||||
| Unknown_jwo_Sso_003_1508.17 | 19615.2073 | 20911.9276 | 19092.1395 | 18788.5566 | 24280.315 | 19967.2357 | 15886.1937 | 19791.65362857143 | 1.0164527388966813 | 1 | ||||||||
| Unknown_jwo_Sso_008_2292.5 | 60849.4373 | 118737.4269 | 63956.4664 | 31967.9283 | 37918.9699 | 160198.397 | 93764.1699 | 81056.11367142857 | 1.3188821897619163 | 1 | ||||||||
| Unknown_jwo_Sso_010_2480.86 | 7957.576 | 9351.9322 | 8588.0958 | 11306.3134 | 19019.0032 | 17823.1628 | 10690.5438 | 12105.232457142858 | 0.24051239668149055 | 0.00762545249175134 | ||||||||
| Unknown_jwo_Sso_035_2378.7 | 6144.4559 | 11575.757 | 6226.0596 | 13892.6234 | 14871.2536 | 13006.2731 | 11645.5994 | 11051.717428571428 | 1.9951116000136409 | 0.0275461426720885 | ||||||||
| Unknown_Sso_jwo_017 | 7126.2796 | 7935.2763 | 7870.0227 | 8387.3675 | 8697.3348 | 8078.4521 | 5598.5514 | 7670.4692000000005 | 0.681611452589935 | 0.00762545249175134 | ||||||||
| Norspermidine | 188526.8464 | 268085.9199 | 186135.2743 | 177339.4676 | 202408.9796 | 200625.3473 | 254479.0765 | 211085.84451428568 | 30.642932095914993 | 0.00762545249175134 | ||||||||
| valine | 38015.5929 | 66558.0266 | 65328.7638 | 70288.3756 | 102165.263 | 88506.9573 | 95736.0589 | 75228.43401428571 | 0.9327660424181773 | 1 | ||||||||
| adenine | 44601.6655 | 19478.7559 | 57144.2211 | 17187.402 | 7904.7423 | 16010.889 | 34051.8406 | 28054.2166285714 | N/A | N/A | ||||||||
| catechol | ND | 653.8836 | 554.6371 | 540.0373 | 758.333 | 729.9228 | 660.1033 | 556.702442857143 | N/A | N/A | ||||||||
| guanine | 7033.0182 | 5094.2742 | 8851.8217 | 1826.0956 | ND | ND | 8354.0544 | 4451.32344285714 | N/A | N/A | ||||||||
| NA260 | 2396.0867 | 4113.4413 | 3960.551 | 3457.6306 | 9291.3687 | ND | 10693.4886 | 4844.65241428572 | N/A | N/A | ||||||||
| 2-amino-2-deoxy-glucose | 80432.3144 | 85488.0225 | 80628.5142 | 55125.3425 | 49480.523 | 84701.8004 | 75059.7348 | 72988.0359714286 | N/A | N/A | ||||||||
| Unknown_jwo_Sso_029_1807.5 | 7453.0747 | 8553.5222 | 8396.8346 | 8825.3708 | 7975.4882 | 4770.2607 | 6483.9033 | 7494.06492857143 | N/A | N/A | ||||||||
| Unknown_jwo_Sso_030_2126.35 | 7325.6918 | 15966.1126 | 7308.2801 | 7782.5507 | 5698.6401 | 5470.1121 | 14350.2235 | 9128.80155714286 | N/A | N/A | ||||||||
| Unknown_jwo_Sso_032_2287.46 | 46256.9729 | 80816.8281 | 47475.6131 | 46628.6123 | 51624.0621 | 34721.9233 | 62875.6161 | 52914.2325571429 | N/A | N/A | ||||||||
| Unknown_jwo_Sso_033_2298.2 | 119743.1024 | 204463.887 | 121185.5811 | 122317.3772 | 136705.9049 | 85282.8371 | 166759.4168 | 136636.872357143 | N/A | N/A | ||||||||
| Unknown_jwo_Sso_034_2347.2 | 20019.891 | 22792.7986 | 13714.1699 | 27190.8853 | 26818.4054 | 40105.5108 | 25146.6758 | 25112.6195428571 | N/A | N/A | ||||||||
| Unknown_jwo_Sso_036_2386.5 | 78896.3248 | 58191.8333 | 63722.2554 | 36250.332 | 11272.9644 | 1308.7353 | 98808.9963 | 49778.7773571428 | N/A | N/A | ||||||||
| Unknown_jwo_Sso_038_2306.5 | 21450.4259 | 11908.8386 | 15545.6563 | 16835.4359 | 24542.8731 | 18648.9323 | 21329.1877 | 18608.7642571429 | N/A | N/A | ||||||||
| Normalized Peak area | ||||||||||||||||||
| Cultivation 1 | Cultivation 2 | Cultivation 3 | Cultivation 4 | Cultivation 5 | ||||||||||||||
| compound | Phenol_1 | Phenol_2 | Phenol_3 | Phenol_4 | Phenol_5 | Phenol_6 | Phenol_7 | Phenol_8 | Mean phenol | Fold-change phenol | p-value | |||||||
| 2-Pentenoyl-CoA | 22789.81925773041 | 14054.593447150277 | 21871.928867187085 | 22344.182637050144 | 47818.08285850411 | 38906.90764865573 | 41266.066585700566 | 48665.5038604645 | 32214.635645305352 | 0.6231789383431648 | 0.0746728165184392 | |||||||
| 3-Hydroxy-2-methylbutanoyl-CoA | 84254.32760101526 | 97062.68210063143 | 102483.07414579681 | 132023.07882473618 | 186288.7387799396 | 128437.21871349892 | 172634.19907827457 | 173257.29242390144 | 134555.07645847427 | 0.32925672551566226 | 0.00707892838527425 | |||||||
| 3-Hydroxybutanoyl-CoA | 24927.501128653097 | 27093.691473422474 | 14297.438142898629 | 11745.721100221319 | 28121.672321321177 | 30533.0208091381 | 21718.15566936076 | 21987.104104430036 | 22553.0380936807 | 4.404787513270152 | 0.00707892838527425 | |||||||
| Acetyl-CoA | 292072.7422312954 | 332318.2581316603 | 333255.77530796605 | 457256.91253653 | 353677.27204876364 | 340172.4852260024 | 355900.5107510885 | 391086.7202320663 | 356967.58455817157 | 0.7173877925487319 | 0.0260296312516711 | |||||||
| β-Hydroxy-β-methylglutaryl-CoA | 68970.0944332827 | 70616.9560743973 | 29023.28621228591 | 34310.741669297866 | 64129.63989263224 | 79172.84689701672 | 67848.44870609646 | 65342.19944650258 | 59926.776666438964 | 0.5223592115785214 | 0.00707892838527425 | |||||||
| Coenzyme A | 34004.27351457158 | 41833.6187121907 | 26632.227420000017 | 62242.95975227296 | 26632.22741999998 | 30035.95249967076 | 26632.227420000003 | 19096.956014649957 | 33388.805344169494 | 1.0505666340110316 | 1 | |||||||
| Crotonoyl-CoA | 4973.637402379227 | 4550.85564347514 | 1384.452341492147 | 544.5404122021622 | 3925.5349327242757 | 4080.8957991548928 | 3165.2214404096344 | 1611.2488322947113 | 3029.548350516524 | 4.142410372368731 | 0.0533456512582505 | |||||||
| Glutaryl-CoA | 17975.58279688683 | 19525.94087266819 | 6476.947860599962 | 6458.447392425675 | 19259.50443805231 | 22831.667225506888 | 19310.21685777376 | 18104.145226345525 | 16242.806583782392 | 11.568053345280436 | 0.00707892838527425 | |||||||
| Isobutanoyl-CoA | 20858.095707036184 | 19873.837204291878 | 48633.46409887614 | 58824.235667407826 | 44168.49733869866 | 31436.08159799996 | 45634.04190990069 | 52528.70320242068 | 40244.619590829 | 2.4255740405881787 | 0.0213035696822119 | |||||||
| Methylmalonyl-CoA | 30490.036785573368 | 30184.31080730293 | 37088.45874371144 | 49346.88323030636 | 31353.266491407507 | 26036.384280701677 | 26309.23536274749 | 29068.497568592815 | 32484.634158792942 | 1.2127147879317115 | 0.0777212476339793 | |||||||
| Isovaleryl-CoA | 15477.944862544364 | 14226.158033256925 | 17414.870457112353 | 25965.364841595085 | 28765.75356990883 | 20946.165267088676 | 34037.62876368056 | 39887.57092746427 | 24590.182090331386 | 0.12753110836186352 | 0.00707892838527425 | |||||||
| Phenylacetyl-CoA | 4056.4626948898517 | 4770.370421099813 | 4172.993530290326 | 4585.07104519683 | 6529.785776063511 | 6819.305183715083 | 10653.580220375781 | 12749.13560527999 | 6792.088059613899 | 1.7330667824421657 | 0.124981702228091 | |||||||
| Propanoyl-CoA | 63586.69658527273 | 71273.28233525608 | 90758.56587816318 | 116790.15602539931 | 89008.12477495511 | 80473.47866190154 | 96771.27864324323 | 107049.33152942658 | 89463.86430420223 | 1.5650407090097254 | 0.00858334957317017 | |||||||
| Succinyl-CoA | 61071.30274993561 | 57846.10713231443 | 45107.22749140659 | 45038.343701434336 | 46184.967766339105 | 31443.759805277492 | 31972.202647388287 | 31872.69146525941 | 43817.0753449194 | 0.6080366353516615 | 0.0435115789524878 | |||||||
| Butanoyl-CoA | 7829.923145939568 | 9380.707580346325 | 8637.926204001138 | 11326.81093407934 | 12183.466636999588 | 13815.988860102709 | 10679.331116137777 | 13550.393695343675 | 10925.568521618767 | N/A | N/A | |||||||
| Malonyl-CoA | 23110.76349941279 | 22791.203396354424 | 28358.014600882885 | 32585.72139529609 | 18072.85888085821 | 27862.18757239511 | 27926.560871645364 | 29505.669620433033 | 26276.622479659738 | N/A | N/A | |||||||
| Acetoacetyl-CoA | 5050.780152164543 | 6688.204241082884 | 3964.017694532152 | 3515.5683035282327 | 5907.737542017029 | 11235.561960162915 | 7721.8373817229385 | 5767.292631797305 | 6231.374988375999 | N/A | N/A | |||||||
| ND | not detected | |||||||||||||||||
| N/A | not available as compound was found for only one condition |
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| Normalized peak area | ||||||||||||||
| Cultivation 1 | Cultivation 2 | Cultivation 3 | ||||||||||||
| Compound | Glucose_1 | Glucose_2 | Glucose_3 | Glucose_4 | Glucose_5 | Glucose_6 | Glucose_7 | Glucose_8 | Glucose_9 | Mean glucose | Fold-change glucose | p-value | ||
| (4-hydroxyphenyl)acetate | 9228.6026 | 8901.6819 | 9023.4578 | 8866.0178 | 8812.9066 | 8465.4542 | 11389.3488 | 12565.5632 | 12018.7459 | 9919.086533333333 | 4.971819861834504 | 0.00762545249175134 | ||
| 1,3-diaminopropane | 12778.3842 | 13878.3702 | 17719.7848 | 17251.8317 | 18376.1281 | 13726.7493 | 14164.7321 | 16125.353 | 17244.4762 | 15696.201066666665 | 0.45388674211313185 | 0.00762545249175134 | ||
| 1,6-anhydro-glucose | 2911.6458 | 3935.6307 | 3020.735 | 2696.7476 | 2634.6502 | 2599.3377 | 2969.8346 | 2481.6973 | 3279.5538 | 2947.7591888888896 | 1.2546264220507644 | 0.0312564760425063 | ||
| 1-O-methyl-alpha-glucopyranoside | 181082.4346 | 199970.9096 | 191807.9477 | 151768.438 | 207176.3948 | 254729.9374 | 119253.4337 | 139571.8383 | 151833.1738 | 177466.05643333332 | 0.33535070138059125 | 0.00762545249175134 | ||
| 2-aminoadipic-acid | 5458.5472 | 7421.3356 | 12702.0691 | 7742.2972 | 8165.1187 | 3045.83 | 7742.2972 | 7863.8253 | 7135.6076 | 7475.2142111111125 | 0.09368110781606906 | 0.00762545249175134 | ||
| 2-hydroxy-glutarate | 6620.2904 | 6492.953 | 7125.8222 | 7359.3012 | 8074.6926 | 7928.2776 | 6304.6007 | 7148.4406 | 6698.9432 | 7083.70238888889 | 1.3338393801247523 | 0.583418643852968 | ||
| 2-isopropylmalic acid | 4601.3751 | 4299.2043 | 4701.2793 | 9658.1735 | 9742.0783 | 9836.3471 | 6297.7107 | 7195.2462 | 7214.0504 | 7060.607211111112 | 1.2427106742097374 | 0.861758769271743 | ||
| 2-methyl-malate | 15050.4988 | 13361.6173 | 14952.8375 | 28048.7653 | 28169.1699 | 29026.2331 | 17095.2082 | 19717.3497 | 19239.1024 | 20517.86468888889 | 1.8968759458791995 | 0.194634608254005 | ||
| alanine | 238817.7497 | 238566.4165 | 599467.4312 | 649136.6375 | 612244.3256 | 206318.5387 | 589736.0195 | 598955.4858 | 646340.7067 | 486620.36791111104 | 2.135127451515736 | 0.0479859246049236 | ||
| trehalose | 2333554.738 | 2602921.6714 | 2292262.1408 | 2627086.3579 | 2287919.2968 | 2190209.8629 | 2123096.1413 | 2145071.5528 | 2368662.5297 | 2330087.143511111 | 1.0858567521890556 | 1 | ||
| aspartate | 4768.2656 | 5015.9291 | 5878.8436 | 4512.5947 | 4663.9921 | 3673.8342 | 5700.4028 | 6761.3867 | 5638.6728 | 5179.324622222222 | 0.29435219482851227 | 0.00762545249175134 | ||
| beta-Alanine | 1397.2156 | 1168.4915 | 1389.378 | 1135.4759 | 1195.5836 | 1106.6771 | 1303.4112 | 1357.814 | 1104.8942 | 1239.8823444444445 | 0.10423491750062976 | 0.00762545249175134 | ||
| citrate | ND | ND | 2198.3048 | 3613.4142 | 3423.725 | ND | 3878.7735 | 3309.768 | 4111.7723 | 2281.7508666666668 | 0.2495055911130002 | 1 | ||
| fumarate | 2045.3021 | 2006.8465 | 2020.7532 | 2076.0545 | 2333.0548 | 2249.4243 | 2763.7097 | 3420.6176 | 2850.5327 | 2418.4772666666668 | 0.18959403847113906 | 0.00762545249175134 | ||
| gluconic-acid | 7325.867 | 3291.4243 | 8800.5299 | 17953.7342 | 19838.6265 | 21003.9175 | 4563.4959 | 5362.3397 | 5795.67 | 10437.289444444443 | 9.53641020299474 | 0.00762545249175134 | ||
| glucose | 871161.4053 | 483539.3515 | 704018.7026 | 1098799.5981 | 1150119.4526 | 1155367.7943 | 506532.3424 | 624040.424 | 564246.1722 | 795313.9158888889 | 4.116925686380441 | 0.00762545249175134 | ||
| glutamate | 193711.194 | 330222.6222 | 360236.0396 | 275109.553 | 255666.3557 | 142047.3713 | 381018.4697 | 368933.4068 | 370237.3261 | 297464.70426666667 | 0.6303827731376551 | 0.298447860466645 | ||
| glycerate | 3006.733 | 3525.6274 | 3014.0437 | 2790.7901 | 3505.6504 | 3049.2304 | 2802.9345 | 3112.4864 | 2963.7046 | 3085.6889444444446 | 0.6637757217620317 | 0.00762545249175134 | ||
| glycine | 119466.4966 | 137685.9029 | 139296.5096 | 100510.4026 | 101108.471 | 83088.7506 | 122368.7192 | 130047.4103 | 125135.681 | 117634.26042222224 | 0.5728761271184338 | 0.0147555523839366 | ||
| isoleucine | 77874.7939 | 75297.57 | 59515.5164 | 46384.9185 | 43298.9472 | 49871.3367 | 63200.1295 | 59719.303 | 59366.4624 | 59392.10862222222 | 1.4964676401924484 | 0.0147555523839366 | ||
| lysine | ND | ND | 9965.6539 | 7320.2015 | 7061.8605 | ND | 7265.5354 | 6450.8076 | 7585.725 | 5072.198211111111 | 0.11951575546951533 | 0.00762545249175134 | ||
| malate | 1566.7156 | 1276.5864 | 1424.6309 | 1640.1222 | 1527.3921 | 1483.6075 | 3105.074 | 3789.425 | 3277.6389 | 2121.2436222222223 | 0.46241204500357047 | 0.245548636531663 | ||
| myo-inositol | 14562.7496 | 15046.0887 | 14123.0124 | 13106.1763 | 13086.94 | 13982.7452 | 12783.4898 | 13501.2719 | 13701.9055 | 13766.042155555553 | 0.5908850693004782 | 0.00762545249175134 | ||
| myoinositol-2-phosphate | 3168.1167 | 2613.8622 | 3300.0952 | 3732.0967 | 3899.3769 | 3709.8709 | 4543.3347 | 4356.0627 | 3860.9947 | 3687.090077777778 | 1.136984122718706 | 1 | ||
| NA168015 | 4249.7082 | 6710.2857 | 4956.652 | 4087.5259 | 2821.0272 | 3128.2813 | 3888.3612 | 3252.9898 | 5200.1547 | 4254.998444444444 | 1.4414369905780804 | 0.115272058085891 | ||
| NA228 | 13685.4569 | 13648.5073 | 14832.8295 | 14841.61 | 14622.737 | 14888.7268 | 12978.3284 | 14528.1103 | 14072.2393 | 14233.171722222221 | 1.136799806975768 | 0.0358898294385211 | ||
| NA321 | 6352.7865 | 2050.8571 | 4364.5217 | 12213.8865 | 21084.2473 | 19457.8039 | 3706.8884 | 5727.1455 | 3121.952 | 8675.565433333333 | 2.629608667261512 | 0.298447860466645 | ||
| NA547 | 92816.8271 | 95507.1587 | 93483.0219 | 97784.3279 | 92963.2309 | 96931.0574 | 86493.5017 | 88212.2469 | 87962.3762 | 92461.52763333335 | 2.103781156582918 | 0.00762545249175134 | ||
| Nicotinamide | 26798.7557 | 33364.4295 | 74257.7379 | 74488.5877 | 69589.0901 | 24010.2834 | 64394.4813 | 68811.0927 | 70953.2988 | 56296.41745555555 | 1.1608595266949964 | 1 | ||
| nicotinic acid | 4696.8304 | 4538.275 | 4568.4859 | 4694.842 | 4252.76 | 3973.4899 | 5372.726 | 5273.3746 | 5261.5849 | 4736.929855555555 | 1.081555872584839 | 1 | ||
| putrescine | 433011.9281 | 463298.4889 | 530333.1985 | 531267.8873 | 533849.7006 | 478285.12 | 454804.9827 | 497206.1032 | 504087.931 | 491793.9267 | 0.3143840540424266 | 0.00762545249175134 | ||
| pyroglutamate | 38040.7172 | 48528.831 | 72244.4805 | 67001.7335 | 90948.1136 | 33779.959 | 87233.4394 | 85285.291 | 75774.9063 | 66537.49683333334 | 1.180007233351473 | 1 | ||
| pyruvate | 20613.1187 | 18066.0794 | 12754.6642 | 21975.222 | 14221.5975 | 20187.3089 | 12549.1359 | 16178.9117 | 17430.8934 | 17108.547966666665 | 3.3075371530520137 | 0.00762545249175134 | ||
| serine | 5458.5662 | 5438.7205 | 3805.2116 | 4174.7729 | 4773.9299 | 5129.8879 | 4327.1245 | 4395.8012 | 4254.3571 | 4639.819088888889 | 0.9342324319808326 | 1 | ||
| similar to Inositol (6TMS)317 | 5238.1471 | 5170.9086 | 5194.9679 | 4773.7698 | 5519.0744 | 5043.0763 | 4633.6809 | 4689.1176 | 4675.4713 | 4993.1348777777785 | 0.10468698015446162 | 0.00762545249175134 | ||
| spermidine | 11573.9447 | 14103.2699 | 21510.3428 | 29972.2218 | 41154.9931 | 39736.183 | 14288.4162 | 14143.6274 | 16849.8233 | 22592.535799999998 | 0.03574385237804562 | 0.00762545249175134 | ||
| succinate | 2096.513 | 2012.4896 | 2212.2872 | 2051.0157 | 2034.2264 | 2361.8297 | 2457.0299 | 2444.5571 | 2430.8882 | 2233.4263111111113 | 0.4793265615580935 | 0.00762545249175134 | ||
| succinic-acid-methylester | 4990.9597 | 4790.521 | 4419.2859 | 4991.4756 | 5184.5539 | 4899.9382 | 5216.3695 | 4771.0489 | 4710.2561 | 4886.0454222222215 | 1.7329472613273575 | 0.00762545249175134 | ||
| threonine | 2734.019 | 2727.9268 | 1904.6906 | 1763.3014 | 1861.7324 | 2440.007 | 1778.9461 | 1971.6504 | 1728.2171 | 2101.1656444444443 | 0.382831440054692 | 0.00762545249175134 | ||
| Unknown_1411.4-pae-bth_025 | 127740.5605 | 139537.242 | 124137.6576 | 112305.6301 | 114529.9368 | 103244.8196 | 115733.7391 | 132982.6642 | 110631.1669 | 120093.71297777777 | 2.7319879392255904 | 0.00762545249175134 | ||
| Unknown_1586.9-pae-bth_039 | 1960.2757 | 1908.5057 | 1811.5128 | 1893.5868 | 2138.2815 | 2081.9634 | 1714.8541 | 2013.5528 | 1734.8855 | 1917.4909222222223 | 0.6564623039858622 | 0.0275461426720885 | ||
| Unknown_jwo_Sso_003_1508.17 | 18616.9469 | 20588.5391 | 19949.0632 | 19810.3594 | 18739.2472 | 19526.8408 | 18439.3641 | 18546.0244 | 21025.292 | 19471.29745555556 | 0.9838135721740098 | 1 | ||
| Unknown_jwo_Sso_008_2292.5 | 66795.3423 | 79057.6124 | 77597.1296 | 56853.9159 | 58677.9608 | 53201.9769 | 36534.316 | 57192.1235 | 67213.3426 | 61458.19111111111 | 0.7582178361059825 | 1 | ||
| Unknown_jwo_Sso_010_2480.86 | 53803.6529 | 55297.1683 | 53156.7189 | 59007.3402 | 43986.1844 | 45979.9197 | 41946.3405 | 50158.983 | 49642.8051 | 50331.01255555555 | 4.157789842842468 | 0.00762545249175134 | ||
| Unknown_jwo_Sso_035_2378.7 | 4722.3361 | 5461.1528 | 6109.3139 | 6565.7384 | 6557.2447 | 5769.6464 | 4929.4232 | 4880.9666 | 4858.7609 | 5539.398111111111 | 0.501225094372246 | 0.0275461426720885 | ||
| Unknown_Sso_jwo_017 | 11067.8839 | 11284.0057 | 10593.1433 | 10593.1433 | 10560.7855 | 10769.8539 | 11775.1451 | 12532.1577 | 12104.7837 | 11253.433566666667 | 1.4671114990810035 | 0.00762545249175134 | ||
| Norspermidine | 2209.4187 | 2822.1154 | 6791.8286 | 9527.5319 | 13696.0448 | 11250.7297 | 5041.978 | 4860.1265 | 5797.3158 | 6888.5654888888885 | 0.03263395281071389 | 0.00762545249175134 | ||
| valine | 79341.7059 | 83073.7597 | 70759.4826 | 81909.4951 | 79861.3285 | 83553.8194 | 84221.0382 | 79484.3427 | 83653.2553 | 80650.91415555555 | 1.0720801943084464 | 1 | ||
| erythritol | 11572.9776 | 11927.3608 | 11277.506 | 9080.7951 | 9218.7809 | 8985.9904 | 10236.6176 | 10734.1307 | 10438.6666 | 10385.8695222222 | N/A | N/A | ||
| erythronic acid | 9943.8727 | 10607.3502 | 10183.691 | 9668.7416 | 9722.6694 | 9245.841 | 11433.2934 | 11793.527 | 11408.9956 | 10445.3313222222 | N/A | N/A | ||
| fructose | 16043.5258 | 15245.3145 | 17082.3268 | 21734.7644 | 21432.2003 | 20542.6041 | 19367.1433 | 21504.8063 | 21926.8521 | 19431.0597333333 | N/A | N/A | ||
| fructose-6-phosphate | 5353.4271 | 4253.5736 | 5269.6528 | 7160.1056 | 7274.8138 | 7036.327 | 8413.2056 | 8503.7295 | 8419.3291 | 6853.79601111111 | N/A | N/A | ||
| glucose-6-phosphate | 10679.4706 | 7196.1737 | 10549.5463 | 17267.8415 | 17382.8386 | 16835.3934 | 15670.786 | 16633.6498 | 15848.7721 | 14229.3857777778 | N/A | N/A | ||
| glycerol-3-phosphate | 797820.9228 | 845637.3749 | 783615.4216 | 740277.8424 | 679084.4327 | 712573.3521 | 717804.662 | 739739.0595 | 737280.7593 | 750425.980811111 | N/A | N/A | ||
| homoserine | 9070.512 | 9413.1176 | 7636.3841 | 9413.1176 | 9954.0597 | 13764.244 | 11961.3433 | 10966.8401 | 8509.271 | 10076.5432666667 | N/A | N/A | ||
| KDG | 25331.1782 | 21077.5013 | 28026.3546 | 31247.955 | 29807.0565 | 32931.9436 | 18549.4843 | 21294.8629 | 21413.5377 | 25519.9860111111 | N/A | N/A | ||
| lactate | 138079.9412 | 59926.0118 | 76877.5667 | 100595.8574 | 118227.8636 | 116516.4166 | 137996.0436 | 155510.5401 | 135430.5641 | 115462.311677778 | N/A | N/A | ||
| NA_2615.1 | 13426.7043 | 11679.5622 | 9970.2048 | 7593.6794 | 7884.9783 | 12006.3296 | 10731.7222 | 11587.0994 | 10670.9053 | 10616.7983888889 | N/A | N/A | ||
| NA184030 | 15391.0464 | 15332.809 | 17274.6189 | 18973.8015 | 18445.6073 | 18440.7187 | 21837.668 | 23231.2503 | 22884.7753 | 19090.2550444445 | N/A | N/A | ||
| NA192001 | 4984.6442 | 3465.4469 | 4241.3931 | 9028.5665 | 9739.7543 | 10334.3099 | 5116.0938 | 4821.553 | 4372.6549 | 6233.82406666667 | N/A | N/A | ||
| NA289 | 2724.7558 | 2261.5337 | 3291.694 | 4565.6154 | 4610.4694 | 4689.2488 | 4039.2843 | 4577.8604 | 4552.1175 | 3923.61992222222 | N/A | N/A | ||
| NA540 | 5727.3885 | 5420.2723 | 6174.1921 | 5885.9304 | 5597.2964 | 6367.3043 | 4987.7253 | 5087.701 | 5261.6472 | 5612.16194444444 | N/A | N/A | ||
| NA544 | 7206.4638 | 7655.238 | 7443.0815 | 7129.135 | 6908.7409 | 7343.5221 | 5789.1319 | 5845.9907 | 5762.6605 | 6787.10715555556 | N/A | N/A | ||
| palatinose | 69665.8839 | 42345.2785 | 23439.4679 | 19699.0811 | 20862.805 | 61364.4433 | 30016.3543 | 36665.6592 | 24793.7037 | 36539.1863222222 | N/A | N/A | ||
| proline | ND | ND | 9583.0001 | 7513.446 | 7467.4951 | ND | 9285.6838 | 11459.7436 | 11292.238 | 6289.0674 | N/A | N/A | ||
| ribulose | 21007.5345 | 21408.1478 | 19981.33 | 18773.6101 | 18911.4736 | 19202.9032 | 23954.6675 | 25058.1306 | 24995.4304 | 21477.0253 | N/A | N/A | ||
| Unknown_1366.59-ppu-cja_010 | 16274.3427 | 16441.6474 | 16234.2997 | 16274.3427 | 16704.8021 | 16855.3987 | 9428.647 | 19117.2691 | 18727.7014 | 16228.7167555556 | N/A | N/A | ||
| Unknown_jwo_Sso_013_2585 | 21028.7721 | 21222.8001 | 20815.0545 | 20873.3119 | 20157.1522 | 20807.2563 | 19049.0683 | 19682.0033 | 19272.3248 | 20323.0826111111 | N/A | N/A | ||
| alpha-D-galactopyranosid-(1,4)-D-galcatopyranose | 15479.9425 | 12548.3017 | 13701.6879 | 13953.0174 | 13671.4024 | 13875.1636 | 13360.2767 | 13368.056 | 11285.9639 | 13471.5346777778 | N/A | N/A | ||
| Unknown_jwo_Sso_027_2930.14 | 17098.4394 | 14166.5567 | 13979.7604 | 15070.9307 | 17014.9602 | 17784.4337 | 16272.3973 | 18888.7966 | 14419.3756 | 16077.2945111111 | N/A | N/A | ||
| xylulose | 469.207 | 562.8824 | 521.5178 | 465.6516 | 418.1821 | 468.7335 | 448.0274 | 505.8612 | 564.8967 | 491.662188888889 | N/A | N/A | ||
| Normalized Peak area | ||||||||||||||
| Cultivation 1 | Cultivation 2 | Cultivation 3 | ||||||||||||
| compound | Glucose_1 | Glucose_2 | Glucose_3 | Glucose_4 | Glucose_5 | Glucose_6 | Glucose_7 | Glucose_8 | Mean glucose | Fold-change glucose | p-value | |||
| 2-Pentenoyl-CoA | 37343.2539343622 | 39840.96024298731 | 42940.253388022684 | 48665.5038604645 | 49612.37686173772 | 70521.40272895958 | 58287.160028158425 | 66341.39200269686 | 51694.03788092366 | 1.6046755409588822 | 0.0746728165184392 | |||
| 3-Hydroxy-2-methylbutanoyl-CoA | 345399.4795279114 | 427662.4327750684 | 365888.7747967919 | 368257.853210525 | 345078.17309347825 | 503310.6404896896 | 482874.50085760996 | 430833.0014578218 | 408663.10702611203 | 3.0371437316393757 | 0.00707892838527425 | |||
| 3-Hydroxybutanoyl-CoA | 6650.2114415122505 | 4058.9967783713737 | 5066.680623732745 | 5810.61582857138 | 6518.813673730973 | 3564.657199192338 | 5157.579667422757 | 4133.4001583864565 | 5120.119421365034 | 0.2270257071396371 | 0.00707892838527425 | |||
| Acetyl-CoA | 568054.803298678 | 689952.8563908815 | 515762.8529317505 | 452217.1547027 | 453528.064814431 | 444473.77727879863 | 434191.9748817541 | 422567.43020303646 | 497593.61431275384 | 1.3939462176338473 | 0.0260296312516711 | |||
| β-Hydroxy-β-methylglutaryl-CoA | 108227.99373489032 | 111801.54768624599 | 136791.82903131552 | 133894.239837838 | 133990.171975038 | 102766.96111203209 | 96325.08593004229 | 93988.63392498947 | 114723.30790404897 | 1.9143914337761792 | 0.00707892838527425 | |||
| Coenzyme A | 37321.60546458517 | 35580.599728714194 | 20600.969631919237 | 26632.22742 | 22889.68166707652 | 37734.9620893306 | 32310.051828528995 | 41183.59166075973 | 31781.711186364304 | 0.9518672758357367 | 1 | |||
| Crotonoyl-CoA | 858.0828819829546 | 939.0526710616002 | 1029.957098708883 | 550.609071428565 | 715.0488295061816 | 589.9083378039986 | 621.6841734279192 | 546.4502244023271 | 731.3491610403038 | 0.24140534377528985 | 0.0533456512582505 | |||
| Glutaryl-CoA | 1755.8887982829497 | 1648.7073779035181 | 1797.7464507895052 | 1701.9186 | 984.4866566452312 | 1334.8327824478874 | 1496.433672128842 | 512.8568106262022 | 1404.108893603017 | 0.08644496789150635 | 0.00707892838527425 | |||
| Isobutanoyl-CoA | 21233.798076831717 | 23265.390380132732 | 18189.22001670161 | 14101.2806511629 | 15755.700957796651 | 13346.338278115247 | 12634.005707011647 | 14208.600707928266 | 16591.791846960095 | 0.41227354154792545 | 0.0213035696822119 | |||
| Methylmalonyl-CoA | 26544.891481710005 | 29137.457287444126 | 28506.233533549414 | 26036.3842807017 | 26017.74316731106 | 26489.9758322066 | 26036.384280701688 | 25524.575976684344 | 26786.70573003862 | 0.8245961952072036 | 0.0777212476339793 | |||
| Isovaleryl-CoA | 141237.29951553335 | 156453.7003302125 | 182057.158203299 | 195278.153399999 | 183103.91103424397 | 262092.08092825065 | 207951.3229761096 | 214363.40045652568 | 192817.1283555217 | 7.841224096967362 | 0.00707892838527425 | |||
| Phenylacetyl-CoA | 3447.7803664702446 | 3104.061617239736 | 4890.600533030134 | 5871.0914871795 | 5543.358638136432 | 3175.193152600026 | 2737.6876931932197 | 2583.146680836968 | 3919.115021085783 | 0.5770118094300103 | 0.124981702228091 | |||
| Propanoyl-CoA | 56797.39762268789 | 59775.59697243397 | 65287.225101752396 | 57906.6870454548 | 61777.822085438675 | 54141.030705789686 | 50114.67898282277 | 51510.93384177503 | 57163.92154476941 | 0.6389610150350318 | 0.00858334957317017 | |||
| Succinyl-CoA | 43038.634951342276 | 56304.90460289943 | 67061.72630769231 | 67061.7263076923 | 62817.447487927304 | 98421.01755307542 | 96791.87582226723 | 85008.3943837096 | 72063.21592707574 | 1.6446377436149782 | 0.0435115789524878 | |||
| ND | not detected | |||||||||||||
| N/A | not available as compound was found for only one condition | |||||||||||||
