Selected Cell
Cell:
Value:
Sample_overview
Mean_metabolite_concentrations
Enzyme_concentration
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| # Overview of samples | |||||||||
| 'training' and 'internal vaildation' samples are used for parameter and internal validation by Copasi. 'validation' samples were used for validation by running steady state simmulations using Tellurium and libroadrunner | |||||||||
| The data available for each sample is shown in code: M=Metabolomics for all metabolites, M*= Metabolomics for most metabolites, P=Proteomics for all enzymes in the model, p=proteomics for targeted enzyme in OE mutants. | |||||||||
| Experiment | Sample type | Sample use | Available data | Growth condition | Enzyme in model | ||||
| 24h_timecourse | growth curve | training data | M+P+U | adherent, non-aerated, non-stirred,glucose 60 mM at t=0 | NA | ||||
| 48h_timecourse | growth curve | training data | M+P+U | adherent, non-aerated, non-stirred, glucose 60 mM at t=0 | NA | ||||
| 6h_timecourse | training data | training data | M+P+U | adherent, non-aerated, non-stirred, glucose 60 mM at t=0 | NA | ||||
| 6h_timecourse_4 | growth curve | Copasi internal validation data | M* | adherent, non-aerated, non-stirred | NA | ||||
| 24h_timecourse_4 | growth curve | Copasi internal validation data | M* | adherent, non-aerated, non-stirred | NA | ||||
| 48h_timecourse_4 | growth curve | Copasi internal validation data | M* | adherent, non-aerated, non-stirred | NA | ||||
| blank_control_7 | control | validation data | M* | adherent, non-aerated, non-stirred | NA | ||||
| water_control_7 | control | validation data | M* | adherent, non-aerated, non-stirred | NA | ||||
| WT_5 | control | validation data | M* | adherent, non-aerated, non-stirred | NA | ||||
| WT_perturbation_7 | control | validation data | M* | adherent, non-aerated, non-stirred | NA | ||||
| KO51_mutant_6 | mutant, glpD KO | validation data | M* | adherent, non-aerated, non-stirred | NA | ||||
| MPN025-OE_6 | mutant, tsr OE | validation data | M*+p | adherent, non-aerated, non-stirred | FBA | ||||
| MPN025-OE_7 | mutant, tsr OE | validation data | M*+p | adherent, non-aerated, non-stirred | FBA | ||||
| MPN051-KO_5 | mutant, glpD KO | validation data | M* | adherent, non-aerated, non-stirred, | NA | ||||
| MPN051-OE_7 | mutant, glpD KO | validation data | M*+p | adherent, non-aerated, non-stirred | NA | ||||
| MPN250-OE_5 | mutant, pgi OE | validation data | M*+p | adherent, non-aerated, non-stirred | PGI | ||||
| MPN250-OE_7 | mutant, pgi OE | validation data | M*+p | adherent, non-aerated, non-stirred | PGI | ||||
| MPN302-OE_6 | mutant, pfkA OE | validation data | M*+p | adherent, non-aerated, non-stirred | PFK | ||||
| MPN302-OE_7 | mutant, pfkA OE | validation data | M*+p | adherent, non-aerated, non-stirred | PFK | ||||
| MPN303-OE_5 | mutant, pyk OE | validation data | M*+p | adherent, non-aerated, non-stirred | PYK | ||||
| MPN303-OE_6 | mutant, pyk OE | validation data | M*+p | adherent, non-aerated, non-stirred | PYK | ||||
| MPN303-OE_7 | mutant, py OE | validation data | M*+p | adherent, non-aerated, non-stirred | PYK | ||||
| MPN430-OE_6 | mutant, gap OE | validation data | M*+p | adherent, non-aerated, non-stirred | GAP | ||||
| MPN606-OE_6 | mutant, eno OE | validation data | M*+p | adherent, non-aerated, non-stirred | ENO | ||||
| MPN627-OE_7 | mutant, ptsI OE | validation data | M*+p | adherent, non-aerated, non-stirred | NA | ||||
| MPN674-KO, NoxE OE_5 | mutant, ldh KO, noxE OE | validation data | M*+p | adherent, non-aerated, non-stirred | LDH, NA | ||||
| MPN674-KO_5 | mutant, ldh KO | validation data | M* | adherent, non-aerated, non-stirred | LDH | ||||
| MPN674-KO_6 | mutant, ldh KO | validation data | M* | adherent, non-aerated, non-stirred | LDH | ||||
| MPN674-OE_5 | mutant, ldh OE | validation data | M*+p | adherent, non-aerated, non-stirred | LDH | ||||
| MPN674-OE_7 | mutant, ldh OE | validation data | M*+p | adherent, non-aerated, non-stirred | LDH | ||||
| Tn674_mutant_7 | mutant, ldh KO | validation data | M* | adherent, non-aerated, non-stirred | LDH | ||||
| Tn051_Gly_perturbation_7 | mutant, perturbation glpD KO | validation data | M* | adherent, non-aerated, non-stirred, glycerol | NA | ||||
| AA_perturbation_6 | perturbation | validation data | M* | adherent, non-aerated, non-stirred | NA | ||||
| Fe_perturbation_6 | Perturbation | validation data | M* | adherent, non-aerated, non-stirred | NA | ||||
| Glu_perturbation_6 | perturbation | validation data | M* | adherent, non-aerated, non-stirred | NA | ||||
| Glucose_starv_perturbation_7 | perturbation | adherent, no aeration, non-stirred | M* | adherent, non-aerated, non-stirred | NA | ||||
| Gly_ctrl_perturbation_7 | perturbation | adherent, non-aerated, non-stirred | M* | adherent, non-aerated, non-stirred | NA | ||||
| Gly_perturbation_6 | perturbation | adherent, non-aerated, non-stirred, glycerol | M* | adherent, non-aerated, non-stirred | NA | ||||
| Ox_perturbation_6 | perturbation | adherent, aerated, non-stirred | M* | adherent, non-aerated, non-stirred | NA | ||||
| WT_noGluc_perturbation_7 | perturbation | adherent, non-aerated, non-stirred | M* | adherent, non-aerated, non-stirred | NA | ||||
| M129_timecourse_24h_3 | growth curve, perturbation | adherent, aerated | M* | adherent, non-aerated, non-stirred | NA | ||||
| M129_timecourse_48h_3 | growth curve, perturbation | adherent, aerated | M* | adherent, non-aerated, non-stirred | NA | ||||
| M129_timecourse_6h_3 | growth curve, perturbation | adherent, aerated | M* | adherent, non-aerated, non-stirred | NA | ||||
| M129_timecourse_96h_3 | time course, perturbation | adherent, aerated | M* | adherent, non-aerated, non-stirred | NA |
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| # Mean metabolite concentrations for all samples used in this study | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| # Proteomics data from ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SampleID | 6h_training_data | 24h_training_data | 48h_training_data | WT_WT_5 | blank_control_7 | WT_perturbation_7 | water_control_7 | TF173_MPN303_5 | TF178_MPN250_5 | TF187_MPN674_5 | Tn051_MPN051_5 | Tn674_N/A_5 | dLDH,NoxE_N/A_5 | KO51_mutant_6 | TF173_mutant_6 | TF183_mutant_6 | TF414_mutant_6 | TF462_mutant_6 | TF463_mutant_6 | Tn674_mutant_6 | TF173_mutant_7 | TF178_mutant_7 | TF184_mutant_7 | Tn674_mutant_7 | TF413_mutant_7 | TF462_mutant_7 | TF463_mutant_7 | TF187_mutant_7 | Tn051_Gly_perturbation_7 | AA_perturbation_6 | Fe_perturbation_6 | Glu_perturbation_6 | Gly_perturbation_6 | Ox_perturbation_6 | Gly_ctrl_perturbation_7 | WT_noGluc_perturbation_7 | 6h_timecourse_4 | 24h_timecourse_4 | 48h_timecourse_4 | B170_timecourse_6h_3 | B170_timecourse_24h_3 | B170_timecourse_48h_3 | B170_timecourse_96h_3 | M129_timecourse_6h_3 | M129_timecourse_24h_3 | M129_timecourse_48h_3 | M129_timecourse_96h_3 | |||||
| Used for | training | training | training | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | internal validation | internal validation | internal validation | validation | validation | validation | validation | validation | validation | validation | validation | |||||
| Batch | 0 | 0 | 0 | 7 | 7 | 7 | 7 | 5 | 5 | 5 | 5 | 5 | 5 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 6 | 6 | 6 | 6 | 6 | 7 | 7 | 4 | 4 | 4 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |||||
| Washed | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||
| Description | 6h_training_data | 24h_training_data | 48h_training_data | WT_WT_5 | blank_control_7 | WT_perturbation_7 | water_control_7 | MPN303-OE_5 | MPN250-OE_5 | MPN674-OE_5 | MPN051-KO_5 | MPN674-KO_5 | MPN674-KO, NoxE OE_5 | MPN674-KO, NoxE OE_6 | MPN303-OE_6 | MPN606-OE_6 | MPN430-OE_6 | MPN025-OE_6 | MPN302-OE_6 | MPN674-KO_6 | MPN303-OE_7 | MPN250-OE_7 | MPN627-OE_7 | MPN674-OE_7 | MPN051-OE_7 | MPN025-OE_7 | MPN302-OE_7 | MPN674-OE_7 | Tn051_Gly_perturbation_7 | AA_perturbation_6 | Fe_perturbation_6 | Glu_perturbation_6 | Gly_perturbation_6 | Ox_perturbation_6 | Gly_ctrl_perturbation_7 | WT_noGluc_perturbation_7 | 6h_timecourse_4 | 24h_timecourse_4 | 48h_timecourse_4 | B170_timecourse_6h_3 | B170_timecourse_24h_3 | B170_timecourse_48h_3 | B170_timecourse_96h_3 | M129_timecourse_6h_3 | M129_timecourse_24h_3 | M129_timecourse_48h_3 | M129_timecourse_96h_3 | |||||
| Growth conditions | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | non-adherent (grown in suspension), aerated | non-adherent (grown in suspension), aerated | non-adherent (grown in suspension), aerated | non-adherent (grown in suspension), aerated | adherent (attached to the bottom of the flask), aerated | adherent (attached to the bottom of the flask), aerated | adherent (attached to the bottom of the flask), aerated | adherent (attached to the bottom of the flask), aerated | |||||
| Time | 6 | 24 | 48 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 6 | 24 | 48 | 6 | 24 | 48 | 96 | 6 | 24 | 48 | 96 | |||||
| ExperimentType | timecourse | timecourse | timecourse | control | control | control | control | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant, perturbation | perturbation | perturbation | perturbation | perturbation | perturbation | perturbation | perturbation | timecourse | timecourse | timecourse | timecourse, perturbation | timecourse, perturbation | timecourse, perturbation | timecourse, perturbation | timecourse, perturbation | timecourse, perturbation | timecourse, perturbation | timecourse, perturbation | |||||
| Genes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | pyk | pgi | ldh | glpD | ldh | 0 | 0 | pyk | eno | gap | tsr | pfkA | ldh | pyk | pgi | ptsI | ldh | glpD | tsr | pfkA | ldh | glpD | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||
| Est. FC | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.291214505 | 1.4085032795 | 1.26939831 | NA | 0 | 0 | 1 | 1.291214505 | 0.549999999999999 | 0.27 | 0.48 | 3.4236509485 | 0 | 1.291214505 | 1.4085032795 | 1.7384333675 | 1.26939831 | 4.03464644 | 0.48 | 3.4236509485 | 1.26939831 | NA | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||
| Effected par | 0 | 0 | 0 | 0 | 0 | 0 | 0 | re07_PYK | re02_PGI | re08_LDH | glpD | re08_LDH | re08_LDH | re08_LDH | re07_PYK | re06_ENO | re06_ENO | re04_FBA | re03_PFK | re08_LDH | re07_PYK | re02_PGI | ptsI | re08_LDH | glpD | re04_FBA | re03_PFK | re08_LDH | glpD | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||
| ParNewValue (log2) | 0:0 | 0:0 | 0:0 | 0:0 | 0:0 | 0:0 | 0:0 | re07_PYK:1.291214505 | re02_PGI:1.4085032795 | re08_LDH:1.26939831 | glpD:NA | re08_LDH:0 | re08_LDH:0 | re08_LDH:1 | re07_PYK:1.291214505 | re06_ENO:0.549999999999999 | re06_ENO:0.27 | re04_FBA:0.48 | re03_PFK:3.4236509485 | re08_LDH:0 | re07_PYK:1.291214505 | re02_PGI:1.4085032795 | ptsI:1.7384333675 | re08_LDH:1.26939831 | glpD:4.03464644 | re04_FBA:0.48 | re03_PFK:3.4236509485 | re08_LDH:1.26939831 | glpD:NA | 0:0 | 0:0 | 0:0 | 0:0 | 0:0 | 0:0 | 0:0 | 0:0 | |||||||||||||||
| CompoundID | Units | SBOTerm | Identifiers: obo.chebi | Identifiers: kegg.compound | ||||||||||||||||||||||||||||||||||||||||||||||||
| AcCoA | mM | SBO:0000299 | cpd:C00024 | 0.013300675017551214 | 0.01438149983680856 | 0.016281481063073516 | 0.018599254513170366 | 0.008927870620606805 | 0.014252844303033217 | 0.011197024240671231 | 0.017381692984073903 | 0.0013310781221683458 | 0.013359095805750237 | 0.017947739422072558 | 0.006211454992349207 | 0.013452191147742043 | 0.01438149983680856 | 0.01438149983680856 | 0.01438149983680856 | 0.01438149983680856 | 0.01438149983680856 | 0.01438149983680856 | 0.01438149983680856 | 0.013864237983276717 | 0.012703497992348269 | 0.013125406950504797 | 0.013707245341331917 | 0.01858653201294757 | 0.013731043230713679 | 0.017896848147118793 | 0.01501836795844838 | 0.015498995063875854 | 0.01438149983680856 | 0.01438149983680856 | 0.01438149983680856 | 0.01438149983680856 | 0.01438149983680856 | 0.012299746344743874 | 0.012749571634248578 | 0.01438149983680856 | 0.01438149983680856 | 0.01438149983680856 | 0.009027137089355996 | 0.0046659710165987 | 0.00868176293019125 | 0.013961442567014426 | 0.015604151094247327 | 0.017753676075644917 | 0.022252815341584718 | 0.01842351264108359 | ||
| ACE | mM | SBO:0000300 | cpd:C00033 | 1.2389363899612698 | 0.87378 | 0.5419331025386449 | 1.081798612169658 | 1.0091747609318953 | 0.9988526689122941 | 0.7776488413444805 | 1.0011634343932245 | 0.6855522965692044 | 0.9393750211518167 | 0.9183496893639064 | 0.8142002390467478 | 0.8177997515804195 | 0.6935685344738104 | 0.9375355665105845 | 0.958830133518421 | 0.8473421349664967 | 0.8394800278691522 | 0.8034602163951948 | 0.7283741512290415 | 0.845271367853749 | 0.8972790140232894 | 0.974729339691394 | 0.9563571525580783 | 0.848370196196572 | 0.8803104278964708 | 0.9553120100521124 | 1.1111073392761264 | 0.7473918702441872 | 0.7963452502988778 | 0.7449424526036622 | 0.5940705957849405 | 0.9130743718629505 | 0.9626268741688915 | 0.8580165147998755 | 0.40817162009745794 | 1.000523101685868 | 0.8354612641457676 | 0.6569226107274477 | 0.5086752636894165 | 0.43698165719289794 | 0.396587560451724 | 0.3054372399813487 | 0.3616689425797333 | 0.4970199524587031 | 0.33103576594166756 | 0.28811292808027117 | ||
| ADP | mM | SBO:0000301 | cpd:C00008 | 0.5633681860910009 | 0.5230327376535936 | 0.724075282870321 | 0.8015501619335115 | 0.07197089372285259 | 0.5894418609970016 | 0.2925534656773315 | 0.730635101451674 | 0.48618042264270034 | 0.48472037871283585 | 0.3300546474818259 | 0.42485228510653267 | 0.7117183321361629 | 0.41158324538851393 | 0.7879158612524467 | 0.9995170813693901 | 0.7982048404683372 | 0.5602859828740057 | 0.7101919284854609 | 0.5024508705107581 | 0.5542788847583868 | 0.5715119460506488 | 0.5125356340847097 | 0.3944236100975902 | 0.7442892465659956 | 0.5429328056862202 | 0.6291831397883546 | 0.6364112340177758 | 0.4387178303723557 | 0.5900023870004731 | 0.36544534497708986 | 1.4156553499595301 | 0.5297871878525571 | 0.06991672902524056 | 0.48192914902881084 | 0.6453373327165368 | 0.34711274285499744 | 0.5132582158460601 | 0.9315551340363857 | 0.1044233756910003 | 0.07225884793025351 | 0.1946627919755695 | 0.3232867076500897 | 0.6823186141089272 | 0.3629721339955787 | 0.622076517668109 | 0.6193522864904574 | ||
| ATP | mM | SBO:0000302 | cpd:C00002 | 0.00390695990562768 | 0.056103326543856406 | 0.07995499434134719 | 0.07560522080986634 | 0.03303474988450116 | 0.0651182742784609 | 0.05344952528918832 | 0.06527168328112669 | 0.03980743931876934 | 0.04212526356863603 | 0.0375871790682073 | 0.03587873758309309 | 0.04681946004225409 | 0.036656942884583994 | 0.07053261140484442 | 0.0949417145716451 | 0.08736158982633975 | 0.06480020162210404 | 0.06640106687165706 | 0.051791471114499436 | 0.06243955474321888 | 0.05543380177853224 | 0.050329789866395754 | 0.06042775322704047 | 0.07907749662440926 | 0.05118538170635088 | 0.05632354233278305 | 0.05810071443674632 | 0.051434863237916094 | 0.05469835941967887 | 0.04215853713437326 | 0.19000897012208418 | 0.05702647651173969 | 0.023535364195838723 | 0.05310150082400479 | 0.0594343240620304 | 0.04649892359497067 | 0.05021769399247235 | 0.0933882468561983 | 0.07385473717416734 | 0.04873186029645356 | 0.08532486231513024 | 0.252462538255123 | 0.27731929077286993 | 0.3544448032411648 | 0.4915529873297403 | 0.4492444653750849 | ||
| CoA | mM | SBO:0000303 | cpd:C00010 | 0.004916760236965332 | 0.00423891865289675 | 0.004466344350856429 | 0.005502422583092644 | 0.0024201508470089264 | 0.004591842120150057 | 0.002643195021954407 | 0.004579503162068949 | 0.0032812675500688703 | 0.004467555030871383 | 0.004060690184497973 | 0.002744691356795314 | 0.004478666767876015 | 0.00423891865289675 | 0.00423891865289675 | 0.00423891865289675 | 0.00423891865289675 | 0.00423891865289675 | 0.00423891865289675 | 0.00423891865289675 | 0.00366080010528382 | 0.004901692610941595 | 0.005106265951286251 | 0.00397056431858127 | 0.004855028485940773 | 0.004809457121108732 | 0.00399413932801251 | 0.006378335210906857 | 0.0032241962472652347 | 0.00423891865289675 | 0.00423891865289675 | 0.00423891865289675 | 0.00423891865289675 | 0.00423891865289675 | 0.0027063297170847635 | 0.002861453994626355 | 0.00423891865289675 | 0.00423891865289675 | 0.00423891865289675 | 0.00423891865289675 | 0.00423891865289675 | 0.00423891865289675 | 0.00423891865289675 | 0.00423891865289675 | 0.00423891865289675 | 0.00423891865289675 | 0.00423891865289675 | ||
| DGP | mM | SBO:0000304 | cpd:C00236 | 9.98442837601393E-6 | 3.0637042181931676E-4 | 5.244389422639102E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.2950855652600096E-4 | 3.2269232072968865E-4 | 2.6349335683458137E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | 3.0637042181931676E-4 | ||
| F6P | mM | SBO:0000305 | cpd:C00085 | 0.031092680419204814 | 0.05147393842919186 | 0.07493878494154056 | 0.0647712081425276 | 0.03940187691504512 | 0.06017405863856272 | 0.06733378166668923 | 0.053036424142801734 | 0.04558707476052733 | 0.045084530724255154 | 0.04571403942767212 | 0.03942405090290874 | 0.050937275289951865 | 0.03507886466279751 | 0.06442163059230423 | 0.06458068491106188 | 0.06429527265078995 | 0.055945806181237956 | 0.05937751503883926 | 0.050440917793056046 | 0.04888080932555338 | 0.04994947529190845 | 0.05983005572367897 | 0.054564505240507995 | 0.05707865181254634 | 0.05483252060669569 | 0.06123516837571728 | 0.06318429355229428 | 0.04583457848276121 | 0.048006356064586336 | 0.05042671554616464 | 0.04941094200427825 | 0.04077938789911474 | 0.028242240911345397 | 0.04862973414218786 | 0.030751255606619565 | 0.046525664467330745 | 0.058919158131927246 | 0.06884648838983429 | 0.03279301006582435 | 0.032436928841631275 | 0.03887690698294138 | 0.03469673093316283 | 0.03920983629308796 | 0.034166161803897255 | 0.033774934519672166 | 0.02717279681155721 | ||
| FBP | mM | SBO:0000306 | cpd:C00354 | 0.05903448091299064 | 0.14571477370590752 | 0.23278412319474184 | 0.11603173136748361 | 0.0654464743308241 | 0.1268491650848864 | 0.13669402236242192 | 0.11556635328590123 | 0.10449966564622508 | 0.14638664609562946 | 0.09210470958980677 | 0.12655424098455995 | 0.23764470601733356 | 0.10937393885479449 | 0.14301155824220224 | 0.20868114329301435 | 0.16724801775639875 | 0.11651764989096637 | 0.16758062679169078 | 0.13222959036747603 | 0.13418720410326535 | 0.1420404094986479 | 0.17306311450532508 | 0.19318271553085212 | 0.22014750013271295 | 0.10598068159009626 | 0.15519355655242734 | 0.14408780131968218 | 0.1030522153523653 | 0.154563457949949 | 0.16606857061758745 | 0.21474813808885906 | 0.171847373819088 | 0.26324852232417034 | 0.21114417830077373 | 0.10538627558557553 | 0.09336638194621116 | 0.1930900911021881 | 0.29620468807238864 | 0.045327915738578854 | 0.034438422852114 | 0.055127967956376686 | 0.06548732234182793 | 0.2084546391775678 | 0.17940875509719192 | 0.1612149965860639 | 0.08563205033076038 | ||
| G6P | mM | SBO:0000307 | cpd:C00085 | 0.03172346792851546 | 0.04042098812640118 | 0.05508415358354321 | 0.05086294764219913 | 0.03094114900750881 | 0.04725293972002171 | 0.05287526216784313 | 0.04164796275482165 | 0.0357982051470074 | 0.035403571918172685 | 0.0358979068107958 | 0.030958561595849674 | 0.03999956215743365 | 0.0275464131032655 | 0.05058843454998116 | 0.05071333528472481 | 0.05048920933020025 | 0.04393261592921528 | 0.046627437177004266 | 0.03960978703820365 | 0.038384679192073494 | 0.03922387152231551 | 0.04698280422694901 | 0.04284792043809724 | 0.04482220668542198 | 0.043058385117213806 | 0.048086198363040344 | 0.04961678972681693 | 0.035992562628151335 | 0.03769799645596881 | 0.039598634426406605 | 0.03880097698015965 | 0.0320228683557895 | 0.022177811128845783 | 0.03818751714628187 | 0.024148067462468933 | 0.036535252370360094 | 0.04626750281687306 | 0.054063146801522084 | 0.0257513979102852 | 0.025471777671881607 | 0.030528905374325913 | 0.027246334589368433 | 0.03079034508737367 | 0.026829694069354985 | 0.026522474651277227 | 0.02133800775302963 | ||
| GAP | mM | SBO:0000308 | cpd:C00118 | 0.027710070832295045 | 0.029329343511964423 | 0.04853032544273774 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.029329343511964423 | 0.02610589300260916 | 0.02839005567114682 | 0.03535999386004328 | 0.011609721801311947 | 0.014435010980746382 | 0.01853097150287047 | 0.02279649375297169 | 0.026734068210838072 | 0.01775718870670458 | 0.024493719579209584 | 0.02781084858111051 | ||
| LAC | mM | SBO:0000309 | cpd:C00184 | 3.13806723328448 | 3.8294 | 2.7540074003758677 | 3.8294 | 3.8848000424121225 | 4.3105623674101965 | 6.283182760623529 | 3.8294 | 3.8294 | 3.8294 | 3.8294 | 3.8294 | 3.8294 | 2.9112685603217803 | 4.865915975599665 | 4.278170528572395 | 3.8261026571162637 | 3.6313643402154585 | 3.7670815601297996 | 3.835239041606232 | 3.1100974928039986 | 3.7905935501245356 | 4.044523435191276 | 3.693031049025982 | 3.1085914364358453 | 3.8743375899716646 | 3.855232976784454 | 4.3858161393255335 | 3.2335578692526177 | 3.9703507060076664 | 3.7828438096320385 | 3.699428931683985 | 3.2998386834919304 | 3.3456411226409455 | 4.45175159351052 | 2.9072677912461313 | 3.8294 | 3.8294 | 3.8294 | 3.8294 | 3.8294 | 3.8294 | 3.8294 | 3.8294 | 3.8294 | 3.8294 | 3.8294 | ||
| NAD | mM | SBO:0000310 | cpd:C00003 | 0.13696370629346688 | 0.12081 | 0.07177657882007558 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | 0.12081 | ||
| NADH | mM | SBO:0000311 | cpd:C00004 | 0.06876397057851581 | 0.06822404934887696 | 0.05760672629036779 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | 0.06822404934887696 | ||
| PEP | mM | SBO:0000312 | cpd:C00074 | 0.270800009610089 | 0.4025435907644677 | 0.48409622104048006 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | 0.4025435907644677 | ||
| Pi_Int | mM | SBO:0000313 | cpd:C00009 | 9.92586205443234 | 6.946300000000001 | 5.870729669588647 | 6.946300000000001 | 6.946300000000001 | 6.946300000000001 | 6.946300000000001 | 6.946300000000001 | 6.946300000000001 | 6.946300000000001 | 6.946300000000001 | 6.946300000000001 | 6.946300000000001 | 4.774671574213978 | 7.812119778290903 | 7.797993203458634 | 6.778913266886627 | 6.944312663852358 | 7.100970634366198 | 7.317571174455097 | 6.946300000000001 | 6.946300000000001 | 6.946300000000001 | 6.946300000000001 | 6.946300000000001 | 6.946300000000001 | 6.946300000000001 | 6.946300000000001 | 6.946300000000001 | 7.567794620848564 | 7.27316417360252 | 5.811530459414198 | 6.117386383512358 | 6.362412365421402 | 6.946300000000001 | 6.946300000000001 | 6.946300000000001 | 6.946300000000001 | 6.946300000000001 | 3.7300362908941826 | 2.843106080009182 | 3.7353426227575546 | 3.990376455347888 | 2.9278641073118123 | 3.481212017187899 | 3.8128678315785933 | 4.670402081369713 | ||
| PYR | mM | SBO:0000314 | cpd:C00022 | 1.0025528935793355 | 1.405039198852948 | 0.9284708518893254 | 1.5686277951421088 | 1.3971120877559413 | 1.5698669171423039 | 2.39137017785626 | 1.2863193746790738 | 1.6743412258457744 | 1.5652481635207918 | 1.3100496249414775 | 1.454639687101115 | 1.4582508088805777 | 0.8006727685692833 | 1.7735087891029033 | 1.6725796660172025 | 1.6593215051574497 | 1.9271108519299653 | 1.7541109282623577 | 1.3696204770182323 | 1.1629493793509331 | 1.3792349431250635 | 1.5881228473119118 | 1.3938573526905986 | 1.1893128294427187 | 1.395435947870578 | 1.6120245811138967 | 1.6541810181449077 | 1.211987871717285 | 1.131527912669277 | 2.022483229457571 | 0.9385828209199815 | 1.2170182554028806 | 0.8793189997832769 | 1.5395829918241546 | 1.1158752082419163 | 1.8076263302491828 | 1.9629009041157106 | 1.030972250753765 | 1.6201788188697648 | 1.2194897083740428 | 1.7406953383116335 | 4.7571402576648 | 1.2360152194464034 | 3.846275693119311 | 3.285253965106419 | 4.687310429911335 | ||
| GLC_Ext | mM | SBO:0000315 | cpd:C00031 | 60.317 | 59.603 | 54.47 | 6.349670229610511 | 5.850109669051469 | 6.708026357102523 | 4.2390846047233275 | 6.095120833612963 | 5.331984064404003 | 5.341092950984734 | 5.338575927200611 | 5.47843408549569 | 5.355839840156608 | 4.147785044537566 | 6.466102028970004 | 5.674933702575709 | 5.601188344597346 | 5.779697518075517 | 5.940591746505087 | 5.501896679932625 | 4.6702635166410555 | 5.305939371832807 | 6.310814955089004 | 6.120613408608017 | 5.867573819359134 | 5.340281126578574 | 7.120839710375929 | 7.093190901851104 | 4.666388237559215 | 6.135682807694283 | 5.821354383994361 | 3.327339667370553 | 4.124274319072268 | 5.281980337020155 | 7.277062369885385 | 2.2425041567296127 | 6.696226986748189 | 5.519075347537546 | 4.52317175372403 | 11.382579844523958 | 11.890225858154867 | 12.103427391876458 | 9.232828666823732 | 9.065383747985688 | 9.604175458280176 | 8.37760460961605 | 6.018288677165177 | ||
| O2 | mM | SBO:0000316 | cpd:C00007 | 0.05525440426308392 | 0.05544940133070558 | 0.0404228987501877 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05544940133070558 | 0.05525440426308392 | 0.05544940133070558 | 0.0404228987501877 | 0.05525440426308392 | 0.05544940133070558 | 0.0404228987501877 | 0.014181996444894509 | 0.05525440426308392 | 0.05544940133070558 | 0.0404228987501877 | 0.014181996444894509 | ||
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| # Table contains the enzyme concentration used for model training and for validation simmulations | # Table contains the enzyme concentration used for model training and for validation simmulations | |||||||||||||||||||||||||||||||||||||||||||||||||||
| # For a more detailed overview of how protein concentration was determined from the copy number of individual subunites, we refer to the file trainnig ss_straining-validation_data.xlsx | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SampleID | 6h_training_data | 24h_training_data | 48h_training_data | WT_WT_5 | blank_control_7 | WT_perturbation_7 | water_control_7 | TF173_MPN303_5 | TF178_MPN250_5 | TF187_MPN674_5 | Tn051_MPN051_5 | Tn674_N/A_5 | dLDH,NoxE_N/A_5 | KO51_mutant_6 | TF173_mutant_6 | TF183_mutant_6 | TF414_mutant_6 | TF462_mutant_6 | TF463_mutant_6 | Tn674_mutant_6 | TF173_mutant_7 | TF178_mutant_7 | TF184_mutant_7 | Tn674_mutant_7 | TF413_mutant_7 | TF462_mutant_7 | TF463_mutant_7 | TF187_mutant_7 | Tn051_Gly_perturbation_7 | AA_perturbation_6 | Fe_perturbation_6 | Glu_perturbation_6 | Gly_perturbation_6 | Ox_perturbation_6 | Gly_ctrl_perturbation_7 | WT_noGluc_perturbation_7 | 6h_timecourse_4 | 24h_timecourse_4 | 48h_timecourse_4 | B170_timecourse_6h_3 | B170_timecourse_24h_3 | B170_timecourse_48h_3 | B170_timecourse_96h_3 | M129_timecourse_6h_3 | M129_timecourse_24h_3 | M129_timecourse_48h_3 | M129_timecourse_96h_3 | |||||
| Used for | training | training | training | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | validation | internal validation | internal validation | internal validation | validation | validation | validation | validation | validation | validation | validation | validation | |||||
| Batch | 0 | 0 | 0 | 7 | 7 | 7 | 7 | 5 | 5 | 5 | 5 | 5 | 5 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 6 | 6 | 6 | 6 | 6 | 7 | 7 | 4 | 4 | 4 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |||||
| Washed | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||
| Description | 6h_training_data | 24h_training_data | 48h_training_data | WT_WT_5 | blank_control_7 | WT_perturbation_7 | water_control_7 | MPN303-OE_5 | MPN250-OE_5 | MPN674-OE_5 | MPN051-KO_5 | MPN674-KO_5 | MPN674-KO, NoxE OE_5 | MPN674-KO, NoxE OE_6 | MPN303-OE_6 | MPN606-OE_6 | MPN430-OE_6 | MPN025-OE_6 | MPN302-OE_6 | MPN674-KO_6 | MPN303-OE_7 | MPN250-OE_7 | MPN627-OE_7 | MPN674-OE_7 | MPN051-OE_7 | MPN025-OE_7 | MPN302-OE_7 | MPN674-OE_7 | Tn051_Gly_perturbation_7 | AA_perturbation_6 | Fe_perturbation_6 | Glu_perturbation_6 | Gly_perturbation_6 | Ox_perturbation_6 | Gly_ctrl_perturbation_7 | WT_noGluc_perturbation_7 | 6h_timecourse_4 | 24h_timecourse_4 | 48h_timecourse_4 | B170_timecourse_6h_3 | B170_timecourse_24h_3 | B170_timecourse_48h_3 | B170_timecourse_96h_3 | M129_timecourse_6h_3 | M129_timecourse_24h_3 | M129_timecourse_48h_3 | M129_timecourse_96h_3 | |||||
| Growth conditions | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | adherent (attached to the bottom of the flask), not aerated, not stired | non-adherent (grown in suspension), aerated | non-adherent (grown in suspension), aerated | non-adherent (grown in suspension), aerated | non-adherent (grown in suspension), aerated | adherent (attached to the bottom of the flask), aerated | adherent (attached to the bottom of the flask), aerated | adherent (attached to the bottom of the flask), aerated | adherent (attached to the bottom of the flask), aerated | |||||
| Time | 6 | 24 | 48 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 6 | 24 | 48 | 6 | 24 | 48 | 96 | 6 | 24 | 48 | 96 | |||||
| ExperimentType | timecourse | timecourse | timecourse | control | control | control | control | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant | mutant, perturbation | perturbation | perturbation | perturbation | perturbation | perturbation | perturbation | perturbation | timecourse | timecourse | timecourse | timecourse, perturbation | timecourse, perturbation | timecourse, perturbation | timecourse, perturbation | timecourse, perturbation | timecourse, perturbation | timecourse, perturbation | timecourse, perturbation | |||||
| Genes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | pyk | pgi | ldh | glpD | ldh | 0 | 0 | pyk | eno | gap | tsr | pfkA | ldh | pyk | pgi | ptsI | ldh | glpD | tsr | pfkA | ldh | glpD | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||
| Est. FC | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.291214505 | 1.4085032795 | 1.26939831 | NA | 0 | 0 | 1 | 1.291214505 | 0.549999999999999 | 0.27 | 0.48 | 3.4236509485 | 0 | 1.291214505 | 1.4085032795 | 1.7384333675 | 1.26939831 | 4.03464644 | 0.48 | 3.4236509485 | 1.26939831 | NA | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||
| Effected par | 0 | 0 | 0 | 0 | 0 | 0 | 0 | re07_PYK | re02_PGI | re08_LDH | glpD | re08_LDH | re08_LDH | re08_LDH | re07_PYK | re06_ENO | re06_ENO | re04_FBA | re03_PFK | re08_LDH | re07_PYK | re02_PGI | ptsI | re08_LDH | glpD | re04_FBA | re03_PFK | re08_LDH | glpD | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||
| ParNewValue (log2) | 0:0 | 0:0 | 0:0 | 0:0 | 0:0 | 0:0 | 0:0 | re07_PYK:1.291214505 | re02_PGI:1.4085032795 | re08_LDH:1.26939831 | glpD:NA | re08_LDH:0 | re08_LDH:0 | re08_LDH:1 | re07_PYK:1.291214505 | re06_ENO:0.549999999999999 | re06_ENO:0.27 | re04_FBA:0.48 | re03_PFK:3.4236509485 | re08_LDH:0 | re07_PYK:1.291214505 | re02_PGI:1.4085032795 | ptsI:1.7384333675 | re08_LDH:1.26939831 | glpD:4.03464644 | re04_FBA:0.48 | re03_PFK:3.4236509485 | re08_LDH:1.26939831 | glpD:NA | 0:0 | 0:0 | 0:0 | 0:0 | 0:0 | 0:0 | 0:0 | 0:0 | |||||||||||||||
| Reaction | Enzyme | gene | ||||||||||||||||||||||||||||||||||||||||||||||||||
| 947.6355 | 1 | PTS_Glc | MPN207 | 851.8335000000001 | 591.9764806107745 | 1476.504506 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 591.9764806107745 | 851.8335000000001 | 591.9764806107745 | 1476.504506 | 851.8335000000001 | 591.9764806107745 | 1476.504506 | 947.6355 | 851.8335000000001 | 591.9764806107745 | 1476.504506 | 947.6355 | ||
| 969.962 | 2 | PGI | MPN250 | 971.8344999999999 | 588.6934525710783 | 390.0890062 | 588.6934525710783 | 588.6934525710783 | 588.6934525710783 | 588.6934525710783 | 588.6934525710783 | 1562.7551606972177 | 588.6934525710783 | 588.6934525710783 | 588.6934525710783 | 588.6934525710783 | 588.6934525710783 | 588.6934525710783 | 588.6934525710783 | 588.6934525710783 | 588.6934525710783 | 588.6934525710783 | 588.6934525710783 | 588.6934525710783 | 1562.7551606972177 | 588.6934525710783 | 588.6934525710783 | 588.6934525710783 | 588.6934525710783 | 588.693452571078 | 588.6934525710783 | 588.6934525710783 | 588.6934525710783 | 588.6934525710783 | 588.6934525710783 | 588.6934525710783 | 588.6934525710783 | 588.6934525710783 | 588.6934525710783 | 971.8344999999999 | 588.6934525710783 | 390.0890062 | 971.8344999999999 | 588.6934525710783 | 390.0890062 | 969.962 | 971.8344999999999 | 588.6934525710783 | 390.0890062 | 969.962 | ||
| 537.1555 | 3 | PFK | MPN302 | 510.4189999999999 | 289.75814954164275 | 369.2265023 | 289.75814954164275 | 289.75814954164275 | 289.75814954164275 | 289.75814954164275 | 289.75814954164275 | 289.75814954164275 | 289.75814954164275 | 289.75814954164275 | 289.75814954164275 | 289.75814954164275 | 289.75814954164275 | 289.75814954164275 | 289.75814954164275 | 289.75814954164275 | 289.75814954164275 | 3109.261788989422 | 289.75814954164275 | 289.75814954164275 | 289.75814954164275 | 289.75814954164275 | 289.75814954164275 | 289.75814954164275 | 289.75814954164275 | 3109.261788989422 | 289.75814954164275 | 289.75814954164275 | 289.75814954164275 | 289.75814954164275 | 289.75814954164275 | 289.75814954164275 | 289.75814954164275 | 289.75814954164275 | 289.75814954164275 | 510.4189999999999 | 289.75814954164275 | 369.2265023 | 510.4189999999999 | 289.75814954164275 | 369.2265023 | 537.1555 | 510.4189999999999 | 289.75814954164275 | 369.2265023 | 537.1555 | ||
| 1160.103 | 4 | FBA | MPN025 | 1354.8954999999999 | 1017.6321702984367 | 1183.118523 | 1017.6321702984367 | 1017.6321702984367 | 1017.6321702984367 | 1017.6321702984367 | 1017.6321702984367 | 1017.6321702984367 | 1017.6321702984367 | 1017.6321702984367 | 1017.6321702984367 | 1017.6321702984367 | 1017.6321702984367 | 1017.6321702984367 | 1017.6321702984367 | 1017.6321702984367 | 1419.3360241981663 | 1017.6321702984367 | 1017.6321702984367 | 1017.6321702984367 | 1017.6321702984367 | 1017.6321702984367 | 1017.6321702984367 | 1017.6321702984367 | 1419.3360241981663 | 1017.6321702984367 | 1017.6321702984367 | 1017.6321702984367 | 1017.6321702984367 | 1017.6321702984367 | 1017.6321702984367 | 1017.6321702984367 | 1017.6321702984367 | 1017.6321702984367 | 1017.6321702984367 | 1354.8954999999999 | 1017.6321702984367 | 1183.118523 | 1354.8954999999999 | 1017.6321702984367 | 1183.118523 | 1160.103 | 1354.8954999999999 | 1017.6321702984367 | 1183.118523 | 1160.103 | ||
| 5901.945 | 5 | GAPDH | MPN430 | 5392.31 | 4381.670988312222 | 3359.345242 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 5283.453176072386 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 4381.670988312222 | 5392.31 | 4381.670988312222 | 3359.345242 | 5392.31 | 4381.670988312222 | 3359.345242 | 5901.945 | 5392.31 | 4381.670988312222 | 3359.345242 | 5901.945 | ||
| 2423.715 | 6 | ENO | MPN606 | 2485.315 | 1863.573255702824 | 1530.03261 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 2728.4309470213166 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 1863.573255702824 | 2485.315 | 1863.573255702824 | 1530.03261 | 2485.315 | 1863.573255702824 | 1530.03261 | 2423.715 | 2485.315 | 1863.573255702824 | 1530.03261 | 2423.715 | ||
| 763.1819999999999 | 7 | PYK | MPN303 | 646.4955000000001 | 519.8834330156604 | 719.0703595 | 519.8834330156604 | 519.8834330156604 | 519.8834330156604 | 519.8834330156604 | 1272.3314868359748 | 519.8834330156604 | 519.8834330156604 | 519.8834330156604 | 519.8834330156604 | 519.8834330156604 | 519.8834330156604 | 1272.3314868359748 | 519.8834330156604 | 519.8834330156604 | 519.8834330156604 | 519.8834330156604 | 519.8834330156604 | 1272.3314868359748 | 519.8834330156604 | 519.8834330156604 | 519.8834330156604 | 519.8834330156604 | 519.8834330156604 | 519.8834330156604 | 519.8834330156604 | 519.8834330156604 | 519.8834330156604 | 519.8834330156604 | 519.8834330156604 | 519.8834330156604 | 519.8834330156604 | 519.8834330156604 | 519.8834330156604 | 646.4955000000001 | 519.8834330156604 | 719.0703595 | 646.4955000000001 | 519.8834330156604 | 719.0703595 | 763.1819999999999 | 646.4955000000001 | 519.8834330156604 | 719.0703595 | 763.1819999999999 | ||
| 2170.5494999999996 | 8 | LDH | MPN674 | 2067.9330000000004 | 1378.3943099159542 | 1850.300929 | 1378.3943099159542 | 1378.3943099159542 | 1378.3943099159542 | 1378.3943099159542 | 1378.3943099159542 | 1378.3943099159542 | 3322.771214006856 | 1378.3943099159542 | 0 | 0 | 1378.3943099159542 | 1378.3943099159542 | 1378.3943099159542 | 1378.3943099159542 | 1378.3943099159542 | 1378.3943099159542 | 0 | 1378.3943099159542 | 1378.3943099159542 | 1378.3943099159542 | 3322.771214006856 | 1378.3943099159542 | 1378.3943099159542 | 1378.3943099159542 | 3322.771214006856 | 1378.3943099159542 | 1378.3943099159542 | 1378.3943099159542 | 1378.3943099159542 | 1378.3943099159542 | 1378.3943099159542 | 1378.3943099159542 | 1378.3943099159542 | 2067.9330000000004 | 1378.3943099159542 | 1850.300929 | 2067.9330000000004 | 1378.3943099159542 | 1850.300929 | 2170.5494999999996 | 2067.9330000000004 | 1378.3943099159542 | 1850.300929 | 2170.5494999999996 | ||
| 4960.62 | 9 | PDH | MPN393 | 4907.9800000000005 | 3925.171378243542 | 4033.185625 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 3925.171378243542 | 4907.9800000000005 | 3925.171378243542 | 4033.185625 | 4907.9800000000005 | 3925.171378243542 | 4033.185625 | 4960.62 | 4907.9800000000005 | 3925.171378243542 | 4033.185625 | 4960.62 | ||
| 2271.9410000000003 | 10 | PTA_ACK | MPN533 | 2113.3595 | 1545.6801029020583 | 1302.177587 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 1545.6801029020583 | 2113.3595 | 1545.6801029020583 | 1302.177587 | 2113.3595 | 1545.6801029020583 | 1302.177587 | 2271.9410000000003 | 2113.3595 | 1545.6801029020583 | 1302.177587 | 2271.9410000000003 | ||
| 2366.0000000000005 | 11 | NOXE | 2812.6 | 1914.4166761738581 | 1867.23124 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 1914.4166761738581 | 2812.6 | 1914.4166761738581 | 1867.23124 | 2812.6 | 1914.4166761738581 | 1867.23124 | 2366.0000000000005 | 2812.6 | 1914.4166761738581 | 1867.23124 | 2366.0000000000005 | |||
| 75.85959500000001 | * Not in final model, only used during model selection | ATPase | MPN599 | 55.07215 | 34.83902159514207 | 136.6803893 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 34.83902159514207 | 55.07215 | 34.83902159514207 | 136.6803893 | 55.07215 | 34.83902159514207 | 136.6803893 | 75.85959500000001 | 55.07215 | 34.83902159514207 | 136.6803893 | 75.85959500000001 | ||
