Selected Cell
Cell:
Value:
growth_curveA
carOlina GC b AND c
gene names
metabolic reactions
AA import rates
protein copy numbers
todos datos GC A
A
B
C
D
E
F
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U
V
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X
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AA
AB
AC
AD
AE
AF
1
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molecules/cell.sec | Uptake in mmol/L-cells | ||||||||||||||||||||||||||||||
time HOURS | lac/cell.sec | ace/cell.sec | gluc /cell.sec | Produced ATP/cell.sec | Glucose uptake mmol/L | mol/cell/s, uptake | |||||||||||||||||||||||||
24 | 4777.4239604151735 | 13097.90620979348 | 8937.66508510433 | 22344.162712760823 | 0.2215125483129287 | 1.484133950473513E-20 | 446.6666666666667 | ||||||||||||||||||||||||
48 | 15681.016757030977 | 3092.983147408323 | 9386.99995221965 | 23467.499880549123 | 0.23264893690131397 | 1.5587477478207387E-20 | 4.71303294282827 | Vmax lactis =3.7 (intern to extern volume ratio 0.047 | |||||||||||||||||||||||
72 | 43135.693698511786 | 3782.751492403874 | 23459.222595457835 | 58648.05648864459 | 0.581417196670381 | model predicts 0.045mmol/s glucose uptake, so that about 1 mmol/L..? | |||||||||||||||||||||||||
96 | 50287.873061434104 | 2217.3449816929096 | 26252.60902156351 | 65631.52255390877 | 0.6506489411783134 | 6.7E-17 | Cell Vol. in L | ||||||||||||||||||||||||
120 | 12725.334858557968 | -231.12222865503858 | 6247.106314951465 | 15617.765787378661 | 0.15482930119108781 | 6.022140857*10^23 | Avogadro's number | ||||||||||||||||||||||||
144 | -10921.6243554167 | 44.52460768395325 | 0 | -13596.374684665934 | 0 | ||||||||||||||||||||||||||
t0 (h) | lac/cell.sec | ace/cell.sec | gluc /cell.sec | Produced ATP/cell.sec | dpH | ||||||||||||||||||||||||||
18.25 | 0 | 5961.797483954494 | 2980.898741977247 | 10433.145596920365 | 0.04369461514422124 | ||||||||||||||||||||||||||
26.75 | 6238.824116290289 | 5863.193146159066 | 6051.008631224677 | 21178.530209286368 | 0.033569603109482316 | ||||||||||||||||||||||||||
40.25 | 8652.527379030491 | 5202.479699266616 | 6927.5035391485535 | 24246.26238701994 | 0.024081764061146593 | ||||||||||||||||||||||||||
50.25 | 11004.975569194396 | 3707.633784392389 | 7356.304676793392 | 25747.066368776872 | 0.04676281607554689 | ||||||||||||||||||||||||||
65.5 | 19493.510593138897 | 3177.700212519589 | 11335.605402829244 | 39674.618909902354 | 0.062306606109505225 | ||||||||||||||||||||||||||
77.25 | 34736.11694952898 | 4005.175462729206 | 19370.64620612909 | 67797.26172145182 | 0.12252135998098801 | ||||||||||||||||||||||||||
90 | 52918.3215048531 | 3753.909505042157 | 28336.11550494763 | 99176.4042673167 | 0.19176946261276306 | ||||||||||||||||||||||||||
101 | 36488.85817012686 | 2442.7132731848797 | 19465.78572165587 | 68130.25002579554 | 0.45927144532222464 | ||||||||||||||||||||||||||
120.25 | 29333.505148681335 | 1875.7393658423262 | 15604.622257261832 | 54616.17790041641 | 0.8618702078475984 | ||||||||||||||||||||||||||
142.75 | 12504.92654629627 | 902.6769423173403 | 6703.801744306806 | 23463.306105073818 | 0.9664560821712032 | ||||||||||||||||||||||||||
Correlation acetate export intracellular | |||||||||||||||||||||||||||||||
TIME h | Lactate | Acetate | pH | con. H+ | corLac/H | ||||||||||||||||||||||||||
0 | 4.7315E-5 | 5.299E-6 | 7.9064 | 1.2405092300422253E-8 | 3814.1594479220003 | ||||||||||||||||||||||||||
16.839 | 0.52636 | 1.3715 | 7.8784 | 1.3231223331133686E-8 | 3.9781657888084345E7 | ||||||||||||||||||||||||||
30.387 | 0.98531 | 1.8481 | 7.8291 | 1.48217676203944E-8 | 6.647722628198791E7 | ||||||||||||||||||||||||||
38.129 | 1.3769 | 2.3426 | 7.805 | 1.5667510701081492E-8 | 8.788249941357665E7 | ||||||||||||||||||||||||||
48.968 | 5.6969 | 3.6089 | 7.7583 | 1.7446165981330123E-8 | 3.26541659989736E8 | ||||||||||||||||||||||||||
57.484 | 9.4358 | 3.7477 | 7.6959 | 2.014187980393203E-8 | 4.6846670180992615E8 | ||||||||||||||||||||||||||
68.323 | 20.834 | 4.6963 | 7.5734 | 2.6705456121918948E-8 | 7.80140204491776E8 | ||||||||||||||||||||||||||
76.065 | 34.897 | 5.551 | 7.3817 | 4.152407817569982E-8 | 8.404039664009198E8 | ||||||||||||||||||||||||||
110.9 | 82.097 | 7.238 | 6.9224 | 1.19563879998812E-7 | 6.866371349007386E8 | ||||||||||||||||||||||||||
129.48 | 80.202 | 7.3275 | 6.0605 | 8.699614330652667E-7 | 9.219029367475769E7 | ||||||||||||||||||||||||||
144.19 | 83.697 | 7.6564 | 5.0941 | 8.051930173083075E-6 | 1.0394650500049297E7 |
A
B
C
D
E
F
G
H
I
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35
growth CURVE b | ||||||||||||||||||
2 biological replicates: | WT.1 | WT.2 | ||||||||||||||||
2 technical replicates: | WT.1-R1 | WT.1-R2 | ||||||||||||||||
WT.2-R1 | WT.2-R2 | |||||||||||||||||
ug/mL Protein in 5mL | Glucose (nmol/uL=mM) | Lactate (nmol/uL=mM) | Acetate (nmol/uL=mM) | |||||||||||||||
Time (h) | WT.1-R1 | WT.1-R2 | WT.2-R1 | WT.2-R2 | Time (h) | WT.1 | WT.2 | Time (h) | WT.1 | WT.2 | Time (h) | WT.1 | WT.2 | |||||
0 | 22.24636264931076 | 22.960909633202984 | 21.679090072891928 | 21.591819119453426 | 0 | 61.61898563873938 | 61.20286150817288 | 0 | 0.6897982831951562 | 0.602016479448633 | 0 | 1.290939587517829 | 1.154481865549625 | |||||
24 | 60.86726996248418 | 69.32182035879656 | 60.68181715445085 | 63.44181998426264 | 24 | 48.35500669301099 | 49.538360415959076 | 24 | 8.426452892884383 | 8.212929682021747 | 24 | 9.651754760511832 | 9.42412243373152 | |||||
48 | 84.23454485373064 | 78.35454447919672 | 80.81999849406155 | 77.14363602291454 | 48 | 38.51105157862404 | 36.75552814501315 | 48 | 13.802491353712048 | 15.290035210965227 | 48 | 16.935801928362025 | 16.801179895078505 | |||||
72 | 78.43090778264131 | 79.65272714007985 | 90.49636174548756 | 88.65272505933586 | 72 | 28.706110765859584 | 26.898568909329462 | 72 | 38.39135739535901 | 37.17875503824693 | 72 | 21.80665395494053 | 22.394094394216985 | |||||
96 | 77.11090982177042 | 78.11454366770657 | 72.79090821959757 | 73.77272676554593 | 96 | 25.28608499678586 | 24.15474582129244 | 96 | 43.42628840205078 | 52.217654509093215 | 96 | 16.776703742007317 | 19.652710540667055 | |||||
growth CURVE C | ||||||||||||||||||
ug/mL Protein in 5mL | Glucose (nmol/uL=mM) | Lactate (nmol/uL=mM) | Acetate (nmol/uL=mM) | |||||||||||||||
Time (h) | WT.1-R1 | WT.1-R2 | WT.2-R1 | WT.2-R2 | Time (h) | WT.1 | WT.2 | Time (h) | WT.1 | WT.2 | Time (h) | WT.1 | WT.2 | |||||
0 | 7.639794133034185 | 7.678052148059931 | 8.084317692951288 | 8.472365290576326 | 0 | 47.52275843187799 | 49.33029835067584 | 0 | 0.9606024429530147 | 0.9003475342951671 | 0 | 1.00701013305017 | 0.9653998521854972 | |||||
24 | 37.09636265451257 | 37.59817957748065 | 30.6054526012594 | 40.32545620614831 | 24 | 50.162550487273386 | 48.120936385134264 | 24 | 2.7682503933563987 | 2.6848204667018436 | 24 | 8.251078338054835 | 7.458034018579504 | |||||
48 | 69.725451576493 | 84.5945454714515 | 70.32545360521837 | 78.53999668771569 | 48 | 41.09883102429704 | 39.109233407344874 | 48 | 14.503680158743649 | 19.47342955233663 | 48 | 15.314218566677482 | 16.287170042610267 | |||||
72 | 80.55818178306926 | 76.30363258318468 | 94.07453851136293 | 88.53272405407645 | 72 | 28.394019605666976 | 30.6436918976248 | 72 | 23.284427119093518 | 33.2110487756053 | 72 | 21.659794604976653 | 21.574126701488073 | |||||
96 | 78.11454306819222 | 84.50727126685055 | 74.32909109245647 | 81.11454670949415 | 96 | 19.746424273257137 | 21.866059227712135 | 96 | 36.612946741060206 | 32.891779047927606 | 96 | 24.08910317569411 | 25.037569380292826 | |||||
144 | 47.21727311546152 | 46.65545273845846 | 47.1245434602824 | 46.633637438470664 | 120 | 18.576072733873506 | 18.74512437299882 | 120 | 29.595517413012537 | 36.63869920479326 | 120 | 16.87460683458157 | 20.87042111577491 | |||||
192 | 48.13363925912164 | 49.26818441195922 | 50.713638229153375 | 51.308178304975684 | 144 | 15.26007799744141 | 16.807541303501328 | 144 | 35.89188926858808 | 36.80608446303138 | 144 | 16.06687919401188 | 18.83886029050994 | |||||
240 | 53.89363922791047 | 54.41727145086635 | 52.04454709118063 | 51.308178304975684 | 168 | 16.06631995371321 | 15.533160669208351 | 168 | 35.351095204896204 | 40.321236283650684 | 168 | 15.387650673196191 | 22.21663688947869 | |||||
192 | 14.258778097183093 | 11.163849547330985 | 192 | 37.03785279927773 | 43.772008863612925 | 192 | 16.195381049244745 | 21.35383676471597 | ||||||||||
216 | 14.869960171736109 | 10.38361486478652 | 216 | 35.04207331480184 | 42.43290377360092 | 216 | 14.757379929480598 | 18.643048330461596 | ||||||||||
240 | 12.178153568886037 | 11.189856821058322 | 240 | 34.84893175547949 | 40.630262011096214 | 240 | 13.031774208997435 | 17.82307759831173 | ||||||||||
A
B
C
D
E
F
G
H
I
J
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
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22
23
24
25
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27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
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81
82
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85
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90
91
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95
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100
table S14: Alignment of gene IDs and gene names. | |||||||||
MPN ID | gene name | ||||||||
MPN001 | dnaN | ||||||||
MPN002 | xdj1 | ||||||||
MPN003 | gyrB | ||||||||
MPN004 | gyrA | ||||||||
MPN005 | serS | ||||||||
MPN006 | tmk | ||||||||
MPN007 | holB | ||||||||
MPN008 | thdF | ||||||||
MPN009 | yabD | ||||||||
MPN010 | mpn010 | ||||||||
MPN011 | mpn011 | ||||||||
MPN012 | mpn012 | ||||||||
MPN013 | mpn013 | ||||||||
MPN014 | MPN014 | ||||||||
MPN015 | rimK | ||||||||
MPN016 | rimK | ||||||||
MPN017 | mtd1 | ||||||||
MPN018 | pmd1 | ||||||||
MPN019 | msbA | ||||||||
MPN020 | hepA | ||||||||
MPN021 | dnaJ | ||||||||
MPN022 | pip | ||||||||
MPN023 | metS | ||||||||
MPN024 | rpoE | ||||||||
MPN025 | tsr | ||||||||
MPN026 | engD | ||||||||
MPN027 | rimL | ||||||||
MPN028 | trsB | ||||||||
MPN029 | efp | ||||||||
MPN030 | nusB | ||||||||
MPN031 | mpn031 | ||||||||
MPN032 | yfkM | ||||||||
MPN033 | upp | ||||||||
MPN034 | polC | ||||||||
MPN035 | mpn035 | ||||||||
MPN036 | mpn036 | ||||||||
MPN037 | mpn037 | ||||||||
MPN038 | mpn038 | ||||||||
MPN039 | mpn039 | ||||||||
MPN040 | mpn040 | ||||||||
MPN041 | mpn041 | ||||||||
MPN042 | mpn042 | ||||||||
MPN043 | glpF | ||||||||
MPN044 | tdk | ||||||||
MPN045 | hisS | ||||||||
MPN046 | aspS | ||||||||
MPN047 | pncB | ||||||||
MPN048 | mpn048 | ||||||||
MPN049 | mpn049 | ||||||||
MPN050 | glpK | ||||||||
MPN051 | glpD | ||||||||
MPN052 | mpn052 | ||||||||
MPN053 | ptsH | ||||||||
MPN054 | mpn054 | ||||||||
MPN055 | potA | ||||||||
MPN056 | potB | ||||||||
MPN057 | potI | ||||||||
MPN058 | potD | ||||||||
MPN059 | Gcp | ||||||||
MPN060 | metX | ||||||||
MPN061 | ffh | ||||||||
MPN062 | deoD | ||||||||
MPN063 | deoC | ||||||||
MPN064 | deoA | ||||||||
MPN065 | cdd | ||||||||
MPN066 | cpsG | ||||||||
MPN067 | nusG | ||||||||
MPN068 | secE | ||||||||
MPN069 | rpmG2 | ||||||||
MPN070 | mpn070 | ||||||||
MPN071 | yabC | ||||||||
MPN072 | rnmV | ||||||||
MPN073 | prs | ||||||||
MPN074 | smpB | ||||||||
MPN075 | ywdF | ||||||||
MPN076 | uhpT | ||||||||
MPN077 | uhpT | ||||||||
MPN078 | fruA | ||||||||
MPN079 | fruK | ||||||||
MPN080 | ftsX | ||||||||
MPN081 | glnQ | ||||||||
MPN082 | tklB | ||||||||
MPN083 | mpn083 | ||||||||
MPN084 | mpn084 | ||||||||
MPN085 | mpn085 | ||||||||
MPN086 | mpn086 | ||||||||
MPN087 | mpn087 | ||||||||
MPN088 | mpn088 | ||||||||
MPN089 | hsdS | ||||||||
MPN090 | mpn090 | ||||||||
MPN091 | mpn091 | ||||||||
MPN092 | mpn092 | ||||||||
MPN093 | mpn093 | ||||||||
MPN094 | mpn094 | ||||||||
MPN095 | mpn095 | ||||||||
MPN096 | mpn096 | ||||||||
MPN097 | mpn097 | ||||||||
MPN098 | mpn098 |
A
B
C
D
E
F
G
H
I
J
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
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17
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19
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22
23
24
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28
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30
31
32
33
34
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36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
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77
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79
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82
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91
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95
96
97
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99
100
model_ID | reaction_ID (Yus2009) | equation | gene number | enzyme (short) | EC number | pathway | reversi-bility | ||
M001 | R001/R002 | D-glucose[e] + phosphoenolpyruvate[c] --> D-glucose 6-phosphate[c] + pyruvate[c] | MPN627/MPN207 | PTSI/G | 2.7.3.9/2.7.1.69 | Glycolysis | I | ||
M002 | R003 | [c]: D-glucose 6-phosphate <==> D-fructose 6-phosphate | MPN250 | PGI | 5.3.1.9 | Glycolysis | R | ||
M003 | R004 | [c]: D-fructose 6-phosphate + ATP --> ADP + D-fructose 1,6-bisphosphate + H+ | MPN302 | PFK | 2.7.1.11 | Glycolysis | I | ||
M004 | R005 | [c]: D-fructose 1,6-bisphosphate <==> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate | MPN025 | FBA | 4.1.2.13 | Glycolysis | R | ||
M005 | R006 | [c]: D-glyceraldehyde 3-phosphate <==> dihydroxyacetone phosphate | MPN629 | TIM | 5.3.1.1 | Glycolysis | R | ||
M006 | R007 | [c]: NAD+ + orthophosphate + D-glyceraldehyde 3-phosphate <==> NADH + H+ + 1,3-bisphospho-D-glycerate | MPN430 | GAPDH | 1.2.1.12 | Glycolysis | R | ||
M007 | R008 | [c]: 3-phospho-D-glycerate + ATP <==> ADP + 1,3-bisphospho-D-glycerate | MPN429 | PGK | 2.7.2.3 | Glycolysis | R | ||
M008 | R009 | [c]: 2-phospho-D-glycerate <==> 3-phospho-D-glycerate | MPN628 | PGM | 5.4.2.1 | Glycolysis | R | ||
M009 | R010 | [c]: 2-phospho-D-glycerate <==> phosphoenolpyruvate + H2O | MPN606 | ENO | 4.2.1.11 | Glycolysis | R | ||
M010 | R011 | [c]: ADP + phosphoenolpyruvate + H+ --> ATP + pyruvate | MPN303 | PYK | 2.7.1.40 | Glycolysis | I | ||
M011 | R012 | [c]: (S)-lactate + NAD+ <==> NADH + H+ + pyruvate | MPN674 | LDH | 1.1.1.27 | Pyruvate metabolism | R | ||
M012 | R015 | [c]: lipoamide + H+ + pyruvate --> S-acetyldihydrolipoamide + CO2 | MPN392/MPN393 | PDH-E1 | 1.2.4.1 | Pyruvate metabolism | I | ||
M013 | R016 | [c]: acetyl-CoA + dihydrolipoamide <==> S-acetyldihydrolipoamide + CoA | MPN391 | PDH-E2 | 2.3.1.12 | Pyruvate metabolism | R | ||
M014 | R017 | [c]: dihydrolipoamide + NAD+ <==> lipoamide + NADH + H+ | MPN390 | PDH-E3 | 1.8.1.4 | Pyruvate metabolism | R | ||
M015 | R018 | [c]: acetyl-CoA + orthophosphate <==> acetyl phosphate + CoA | MPN428 | PTA | 2.3.1.8 | Pyruvate metabolism | R | ||
M016 | R019 | [c]: acetate + ATP <==> ADP + acetyl phosphate | MPN533 | ACK | 2.7.2.1 | Pyruvate metabolism | R | ||
M017 | R020 | [c]: (2) NADH + oxygen + (2) H+ <==> (2) H2O + (2) NAD+ | MPN394 | NOX | 1.6.99.3 | Pyruvate metabolism | R | ||
M018 | R190 | (4) H+[e] + ADP[c] + orthophosphate[c] <==> H2O[c] + (3) H+[c] + ATP[c] | MPN597-MPN604 | ATPase | 3.6.3.14 | Energy metabolism | R | ||
M019 | R021 | D-fructose[e] + phosphoenolpyruvate[c] --> D-fructose 1-phosphate[c] + pyruvate[c] | MPN078 | FRUA | 2.7.1.69 | Alternative sugar metabolism | I | ||
M020 | R022 | [c]: D-fructose 1-phosphate + ATP --> ADP + D-fructose 1,6-bisphosphate + H+ | MPN079 | FRUK | 2.7.1.56 | Alternative sugar metabolism | I | ||
M021 | R023 | [c]: D-fructose 1-phosphate --> D-glyceraldehyde + dihydroxyacetone phosphate | MPN025 | FBA | 4.1.2.13 | Alternative sugar metabolism | I | ||
M022 | R024 | [c]: glycerol + NAD+ <==> D-glyceraldehyde + NADH + H+ | MPN564 | ADH | 1.1.1.1 | Alternative sugar metabolism | R | ||
M023 | R026 | D-mannose[e] + phosphoenolpyruvate[c] --> D-mannose 6-phosphate[c] + pyruvate[c] | MPN078 | FRUA | 2.7.1.69 | Alternative sugar metabolism | I | ||
M024 | R028 | [c]: D-mannose 6-phosphate <==> D-fructose 6-phosphate | ? | MPI | 5.3.1.8 | Alternative sugar metabolism | R | ||
M025 | R029 | mannitol[e] + phosphoenolpyruvate[c] --> pyruvate[c] + D-mannitol 1-phosphate[c] | MPN651/MPN653 | MTLA | 2.7.1.69 | Alternative sugar metabolism | I | ||
M026 | R030 | [c]: NAD+ + D-mannitol 1-phosphate <==> NADH + D-fructose 6-phosphate + H+ | MPN652 | MTLD | 1.1.1.17 | Alternative sugar metabolism | R | ||
M027 | R031 | L-ascorbate[e] + phosphoenolpyruvate[c] + (2) H+[c] --> L-ascorbate 6-phosphate[c] + pyruvate[c] | MPN494-MPN496 | PTSA | 2.7.1.69 | Alternative sugar metabolism | I | ||
M028 | R032 | [c]: H2O + L-ascorbate 6-phosphate <==> 3-keto-L-gulonate 6-phosphate + (3) H+ | MPN497 | ULAG | 3.1.1.- | Alternative sugar metabolism | R | ||
M029 | R033 | [c]: 3-keto-L-gulonate 6-phosphate + H+ --> CO2 + L-xylulose 5-phosphate | MPN493 | KGPDC | 4.1.1.85 | Alternative sugar metabolism | I | ||
M030 | R034 | [c]: L-ribulose 5-phosphate <==> L-xylulose 5-phosphate | MPN492 | ULAE | 5.1.3.22 | Alternative sugar metabolism | R | ||
M031 | R035 | [c]: L-ribulose 5-phosphate <==> D-xylulose 5-phosphate | MPN498 | ULAF | 5.1.3.4 | Alternative sugar metabolism | R | ||
M032 | R191 | D-ribose[e] --> D-ribose[c] | MPN258-MPN260 | RibABC | 3.6.3.17 | Pentose phosphate pathway | I | ||
M033 | R036 | [c]: D-ribose + ATP --> ADP + D-ribose 5-phosphate + H+ | ? | RBSK | 2.7.1.15 | Pentose phosphate pathway | I | ||
M034 | R037 | [c]: D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate <==> D-xylulose 5-phosphate + D-erythrose 4-phosphate | MPN082 | TKL | 2.2.1.1 | Pentose phosphate pathway | R | ||
M035 | R038 | [c]: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <==> D-erythrose 4-phosphate + D-fructose 6-phosphate | ? | TAL | 2.2.1.2 | Pentose phosphate pathway | R | ||
M036 | R039 | [c]: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <==> D-xylulose 5-phosphate + D-ribose 5-phosphate | MPN082 | TKL | 2.2.1.1 | Pentose phosphate pathway | R | ||
M037 | R040 | [c]: D-ribulose 5-phosphate <==> D-xylulose 5-phosphate | MPN251 | RPE | 5.1.3.1 | Pentose phosphate pathway | R | ||
M038 | R041 | [c]: D-ribose 5-phosphate <==> D-ribulose 5-phosphate | MPN595 | RPIA | 5.3.1.6 | Pentose phosphate pathway | R | ||
M039 | R042 | [c]: D-ribose 5-phosphate + ATP --> AMP + 5-phospho-alpha-D-ribose 1-diphosphate + H+ | MPN073 | PRPS | 2.7.6.1 | Pentose phosphate pathway | I | ||
M040 | R043 | [c]: D-ribose 1-phosphate <==> D-ribose 5-phosphate + (2) H+ | MPN066 | DEOB | 5.4.2.7 | Pentose phosphate pathway | R | ||
M041 | R044 | [c]: 2-deoxy-D-ribose 1-phosphate <==> 2-deoxy-D-ribose 5-phosphate | MPN066 | DEOB | 5.4.2.7 | Pentose phosphate pathway | R | ||
M042 | R046 | [c]: 2-deoxy-D-ribose 5-phosphate --> acetaldehyde + D-glyceraldehyde 3-phosphate | MPN063 | DERA | 4.1.2.4 | Pentose phosphate pathway | I | ||
M043 | R047 | [c]: acetaldehyde + NAD+ + CoA <==> acetyl-CoA + NADH + H+ | MPN564 | ADH | 1.2.1.10 | Alternative sugar metabolism | R | ||
M044 | R192 | glycerol[c] <==> glycerol[e] | MPN043 | GlpF | - | Alternative sugar metabolism | R | ||
M045 | R049 | [c]: glycerol + ATP --> ADP + sn-glycerol 3-phosphate + H+ | MPN050 | GK | 2.7.1.30 | Alternative sugar metabolism | I | ||
M046 | R193 | sn-glycerol 3-phosphate[e] + H2O[c] + ATP[c] --> ADP[c] + orthophosphate[c] + H+[c] + sn-glycerol 3-phosphate[c] | MPN133-MPN136 | GlyABC | - | Alternative sugar metabolism | I | ||
M047 | R186 | [c]: oxygen + sn-glycerol 3-phosphate <==> H2O2 + dihydroxyacetone phosphate | MPN051 | GPO | 1.1.3.21Â | Lipid metabolism | R | ||
M048 | R051 | [c]: H2O + dihydroxyacetone phosphate --> dihydroxyacetone + orthophosphate | - | - | - | Lipid metabolism | I | ||
M049 | R052 | [c]: dihydroxyacetone + ATP --> ADP + dihydroxyacetone phosphate + H+ | MPN547 | DHAK | 2.7.1.29 | Lipid metabolism | I | ||
M050 | R053 | [c]: ACP-R (Mpn) + sn-glycerol 3-phosphate --> 1-acyl-glycerol 3-phosphate (Mpn) + acyl carrier protein | MPN350/MPN546 | GPAM | 2.3.1.15 | Lipid metabolism | I | ||
M051 | R054 | [c]: ACP-R (Mpn) + 1-acyl-glycerol 3-phosphate (Mpn) --> phosphatidic acid (Mpn) + acyl carrier protein | MPN299 | AGPAT | 2.3.1.51 | Lipid metabolism | I | ||
M052 | R055 | [c]: phosphatidic acid (Mpn) + CTP + H+ --> CDP-diacylglycerol (Mpn) + pyrophosphate | MPN637 | CDP-DG | 2.7.7.41 | Lipid metabolism | I | ||
M053 | R056 | [c]: CDP-diacylglycerol (Mpn) + sn-glycerol 3-phosphate --> CMP + phosphatidylglycerol 3-phosphate (Mpn) + H+ | MPN253 | PGP | 2.7.8.5 | Lipid metabolism | I | ||
M054 | R057 | [c]: H2O + phosphatidylglycerol 3-phosphate (Mpn) --> orthophosphate + phosphatidylglycerol (Mpn) | ? | PGPB | 3.1.3.27 | Lipid metabolism | I | ||
M055 | R058 | [c]: CDP-diacylglycerol (Mpn) + phosphatidylglycerol (Mpn) --> cardiolipin (Mpn) + CMP + H+ | ? | CLS | 2.7.8.- | Lipid metabolism | I | ||
M056 | R059 | [c]: H2O + phosphatidic acid (Mpn) --> diacylglycerol (Mpn) + orthophosphate | MPN455 | PPT | 3.1.3.4 | Lipid metabolism | I | ||
M057 | R060 | [c]: D-glucose 1-phosphate <==> D-glucose 6-phosphate | MPN066 | PGM | 5.4.2.2 | Lipid metabolism | R | ||
M058 | R061 | [c]: D-glucose 1-phosphate + UTP + H+ <==> UDP-glucose + pyrophosphate | MPN667 | UGP | 2.7.7.9 | Lipid metabolism | R | ||
M059 | R062 | [c]: UDP-glucose <==> UDP-galactose | MPN257 | UGE | 5.1.3.2 | Lipid metabolism | R | ||
M060 | R063/R064 | [c]: diacylglycerol (Mpn) + (3) UDP-galactose + (3) UDP-glucose --> glycolipid (Mpn) + (6) H+ + (6) UDP | MPN483 | GTF | - | Lipid metabolism | I | ||
M061 | R178 | [c]: choline + ATP --> ADP + H+ + choline phosphate | MPN532 | CHK | 2.7.1.32 | Lipid metabolism | I | ||
M062 | R180 | [c]: CTP + H+ + choline phosphate --> CDP-choline + pyrophosphate | MPN336 | PCT | 2.7.7.15 | Lipid metabolism | I | ||
M063 | R182 | [c]: sn-glycero-3-phosphocholine + H2O <==> choline + sn-glycerol 3-phosphate + H+ | MPN420 | GlpQ | 3.1.4.46 | Lipid metabolism | R | ||
M064 | R187 | [c]: phosphatidylcholine + (2) H2O <==> sn-glycero-3-phosphocholine + (2) fatty acid (Mpn) | MPN445 | PldB | 3.1.1.5 | Lipid metabolism | R | ||
M065 | R065 | [c]: AMP + pyrophosphate <==> adenine + 5-phospho-alpha-D-ribose 1-diphosphate | MPN395 | APRT | 2.4.2.7 | Nucleotide metabolism | R | ||
M066 | R066 | [c]: adenosine + orthophosphate + (2) H+ <==> D-ribose 1-phosphate + adenine | MPN062 | PNP | 2.4.2.1 | Nucleotide metabolism | R | ||
M067 | R067 | [c]: H2O + AMP --> adenosine + orthophosphate | ? | NT5 | 3.1.3.5 | Nucleotide metabolism | I | ||
M068 | R068 | [c]: AMP + ATP <==> (2) ADP | MPN185 | AK | 2.7.4.3 | Nucleotide metabolism | R | ||
M069 | R069 | [c]: ADP + reduced thioredoxin --> dADP + H2O + oxidized thioredoxin | MPN322-MPN324 | RDR | 1.17.4.1 | Nucleotide metabolism | I | ||
M070 | R070 | [c]: oxidized thioredoxin + H+ + NADPH <==> NADP+ + reduced thioredoxin | MPN240 | TXNRD | 1.8.1.9 | Nucleotide metabolism | R | ||
M071 | R071/R084/R099/R104 | [c]: (28) GTP + (25) UTP + (40) H2O + (18) CTP + (69) ATP --> (40) ADP + RNA (Mpn) + (40) orthophosphate + (40) H+ + (100) pyrophosphate | MPN516 | RNAP | - | Nucleotide metabolism | I | ||
M072 | R072 | [c]: H2O + pyrophosphate --> (2) orthophosphate + H+ | MPN528 | PPA | 3.6.1.1 | Nucleotide metabolism | I | ||
M073 | R073 | [c]: deoxyadenosine + orthophosphate <==> 2-deoxy-D-ribose 1-phosphate + adenine | MPN062 | PNP | 2.4.2.1 | Nucleotide metabolism | R | ||
M074 | R074 | [c]: deoxyadenosine + ATP <==> ADP + H+ + dAMP | MPN386 | DAK | 2.7.1.76 | Nucleotide metabolism | R | ||
M075 | R075 | [c]: dAMP + ATP <==> dADP + ADP | MPN185 | AK | 2.7.4.3 | Nucleotide metabolism | R | ||
M076 | R076 | [c]: phosphoenolpyruvate + dADP + H+ --> dATP + pyruvate | MPN303 | PYK | 2.7.1.40 | Nucleotide metabolism | I | ||
M077 | R175 | [c]: 3-phospho-D-glycerate + dATP <==> dADP + 1,3-bisphospho-D-glycerate | MPN429 | PGK | 2.7.2.3 | Nucleotide metabolism | R | ||
M078 | R077/R089/R110/R120 | [c]: (20) dGTP + (140) H2O + (30) dTTP + (20) dCTP + (140) ATP + (30) dATP --> (140) ADP + DNA (Mpn) + (140) orthophosphate + (140) H+ + (100) pyrophosphate | MPN034/MPN378 | DNAP | - | Nucleotide metabolism | I | ||
M079 | R078 | [c]: GMP + pyrophosphate <==> 5-phospho-alpha-D-ribose 1-diphosphate + guanine | MPN672 | HPRT | 2.4.2.8 | Nucleotide metabolism | R | ||
M080 | R079 | [c]: guanosine + orthophosphate + (2) H+ <==> D-ribose 1-phosphate + guanine | MPN062 | PNP | 2.4.2.1 | Nucleotide metabolism | R | ||
M081 | R080 | [c]: GMP + H2O --> guanosine + orthophosphate | ? | NT5 | 3.1.3.5 | Nucleotide metabolism | I | ||
M082 | R081 | [c]: GMP + ATP <==> ADP + GDP | MPN246 | GUK | 2.7.4.8 | Nucleotide metabolism | R | ||
M083 | R082 | [c]: reduced thioredoxin + GDP --> H2O + oxidized thioredoxin + dGDP | MPN322-MPN324 | RDR | 1.17.4.1 | Nucleotide metabolism | I | ||
M084 | R083 | [c]: phosphoenolpyruvate + H+ + GDP --> GTP + pyruvate | MPN303 | PYK | 2.7.1.40 | Nucleotide metabolism | I | ||
M085 | R176 | [c]: GTP + 3-phospho-D-glycerate <==> GDP + 1,3-bisphospho-D-glycerate | MPN429 | PGK | 2.7.2.3 | Nucleotide metabolism | R | ||
M086 | R085 | [c]: deoxyguanosine + orthophosphate <==> 2-deoxy-D-ribose 1-phosphate + guanine | MPN062 | PNP | 2.4.2.1 | Nucleotide metabolism | R | ||
M087 | R086 | [c]: deoxyguanosine + ATP <==> ADP + H+ + dGMP | MPN386 | DGK | 2.7.1.113 | Nucleotide metabolism | R | ||
M088 | R087 | [c]: ATP + dGMP <==> ADP + dGDP | MPN246 | GUK | 2.7.4.8 | Nucleotide metabolism | R | ||
M089 | R088 | [c]: phosphoenolpyruvate + dGDP + H+ --> dGTP + pyruvate | MPN303 | PYK | 2.7.1.40 | Nucleotide metabolism | I | ||
M090 | R177 | [c]: 3-phospho-D-glycerate + dGTP <==> dGDP + 1,3-bisphospho-D-glycerate | MPN429 | PGK | 2.7.2.3 | Nucleotide metabolism | R | ||
M091 | R090 | [c]: UMP + pyrophosphate <==> uracil + 5-phospho-alpha-D-ribose 1-diphosphate | MPN033 | UPRT | 2.4.2.9 | Nucleotide metabolism | R | ||
M092 | R091 | [c]: orthophosphate + (2) H+ + uridine <==> uracil + D-ribose 1-phosphate | MPN064 | UPP | 2.4.2.3 | Nucleotide metabolism | R | ||
M093 | R092 | [c]: H2O + UMP --> orthophosphate + uridine | ? | NT5 | 3.1.3.5 | Nucleotide metabolism | I | ||
M094 | R093 | [c]: ATP + uridine --> ADP + UMP + H+ | MPN561 | UCK | 2.7.1.48 | Nucleotide metabolism | I | ||
M095 | R094 | [c]: UMP + ATP <==> ADP + UDP | MPN632 | UMPK | 2.7.4.22 | Nucleotide metabolism | R | ||
M096 | R095 | [c]: phosphoenolpyruvate + H+ + UDP --> UTP + pyruvate | MPN303 | PYK | 2.7.1.40 | Nucleotide metabolism | I | ||
M097 | R096 | [c]: reduced thioredoxin + UDP --> H2O + oxidized thioredoxin + dUDP | MPN322-MPN324 | RDR | 1.17.4.1 | Nucleotide metabolism | I | ||
M098 | R097 | [c]: cytidine + H2O --> NH3 + uridine | MPN065 | CDA | 3.5.4.5 | Nucleotide metabolism | I | ||
M099 | R100 | [c]: cytidine + ATP --> ADP + CMP + H+ | MPN561 | UCK | 2.7.1.48 | Nucleotide metabolism | I |
A
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aa | aa in proteome | aa in cytosol | times enrichment | import/min during exp growth | min for intracellular pool tunrover | ||||
L | Leu | 2393036 | 25097.05592913839 | 95.3512637799726 | 1994.1966666666667 | 12.585045571803377 | |||
E | Glu | 1672072 | 98709.27690427659 | 16.93936023481859 | 1393.3933333333334 | 70.84092807315228 | |||
A | Ala | 2032737 | 38012.458206949574 | 53.47554712019039 | 1693.9475 | 22.440163114234398 | |||
V | Val | 1864124 | 12050.334305584664 | 154.69479540796488 | 1553.4366666666667 | 7.75720991023215 | |||
I | Ile | 1724690 | 17162.645565208353 | 100.49091752475763 | 1437.2416666666666 | 11.941377684250517 | |||
S | Ser | 1515135 | 12566.026347110956 | 120.57391558377111 | 1262.6125 | 9.952401348086571 | |||
G | Gly | 1588085 | 34936.658649543664 | 45.4561214891895 | 1323.4041666666667 | 26.39908467081573 | |||
D | Asp | 1305481 | 23289.714936892153 | 56.053970756509706 | 1087.9008333333334 | 21.407939237928844 | |||
T | Thr | 1533247 | 6433.410380326506 | 238.32569498266412 | 1277.7058333333334 | 5.035126405850986 | |||
F | Phe | 1102859 | 39005.54349337493 | 28.27441694761464 | 919.0491666666666 | 42.44119347264693 | |||
R | Arg | 907229 | 38302.24724840229 | 23.686051476727478 | 756.0241666666666 | 50.66272870254671 | |||
P | Pro | 974850 | 35012.34123028322 | 27.843039503934204 | 812.375 | 43.09874285925 | |||
N | Asn | 1473974 | 13655.645188364413 | 107.93880330575162 | 1228.3116666666667 | 11.117410636847932 | |||
M | Met | 469166 | 12369.476786726444 | 37.92933267019484 | 390.97166666666664 | 31.637783096114667 | |||
Q | Gln | 1179691 | 7692.708238618437 | 153.35184481296088 | 983.0758333333334 | 7.825142250252077 | |||
K | Lys | 2149849 | 24800.00990495273 | 86.68742505504648 | 1791.5408333333332 | 13.842838211401489 | |||
H | His | 478238 | 12279.469738303413 | 38.94614427105348 | 398.5316666666667 | 30.811779252096432 | |||
C | Cys | 197940 | 3627.5517146154225 | 54.56572795433869 | 164.95 | 21.991826096486346 | |||
Y | Tyr | 748700 | 5417.454387835065 | 138.20144045535696 | 623.9166666666666 | 8.682977514895256 | |||
W | Trp | 211534 | 6470.8277604091345 | 32.69040806405659 | 176.27833333333334 | 36.708015319007636 | |||
sum | 25522637 | 466890.8569169164 | 80.57381106984371 | ||||||
average | 1063.4432083333334 | 24.35898567139502 | |||||||
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AL
AM
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AV
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701
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753
MPN474-34 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||
MPN474a | 0 | 0 | 215.12 | 213.37 | 157.03 | 169.81 | 217.32 | 222.05 | 151.01 | 227.54 | 229.56 | 224.56 | 227.96 | 241.9 | 233.86 | 243.5 | 226.24 | 153.88 | 168.87 | 112.34 | 186.21 | 189.24 | 184.21 | 181.78 | 178.01 | 177.6 | 294.29 | 303.01 | 219.43 | 225.46 | 0 | 0 | |||||||||||||||||||||||||||||||||||
MPNs002-2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||
MPNs009-17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||
MPNs011-19 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||
MPNs016_15_118 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 78.69 | ||||||||||||||||||||||||||||||||||||||||||||
MPNs017-28 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs017_16_125 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs018-31 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs020 | 0 | 0 | 6.36 | 13.56 | 12.65 | 9.89 | 13.91 | 7.86 | 17.41 | 4.56 | 10.67 | 12.94 | 8.37 | 8.03 | 15.98 | 3.16 | 16.85 | 5.02 | 10.22 | 10.22 | 6.77 | 6.31 | 0 | 0 | 8.34 | 4.52 | 19.05 | 9.05 | 12.04 | 5.57 | |||||||||||||||||||||||||||||||||||||
MPNs020-37 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs021 | 0 | 0 | 4.41 | 3.91 | 1.3 | 0 | 4.6 | 1.96 | 2.34 | 2.9 | 3.1 | 2.08 | 1.98 | 0 | 5.06 | 3.35 | 1.77 | 2.55 | 0.55 | 2.2 | 1.92 | 2.42 | 0 | 0 | 3.89 | 2.33 | 0.62 | 0 | 2.1 | 0.88 | |||||||||||||||||||||||||||||||||||||
MPNs023 | 0 | 0 | 0 | 2.6 | 2.69 | 2.99 | 4.73 | 2.2 | 0 | 0 | 0 | 1.74 | 0 | 0 | 0 | 0 | 0 | 0 | 3.5 | 0 | 5.54 | 5.15 | 0.57 | 5.33 | 6.39 | 2.23 | 0 | 0 | 0.99 | 0 | |||||||||||||||||||||||||||||||||||||
MPNs023-43 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs024 | 0 | 0 | 2.39 | 0 | 2.54 | 2.38 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.85 | 0 | 4.47 | 5.65 | 6.18 | 3.84 | 2.49 | 2.98 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||
MPNs024-45 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs025-48 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs030-54 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs035 | 0 | 0 | 3.55 | 2.5 | 3.62 | 3.22 | 2.54 | 1.52 | 5.01 | 4.76 | 2.48 | 3.42 | 0 | 0 | 3.6 | 3.76 | 3.59 | 1.57 | 2.4 | 4.07 | 2.47 | 2.31 | 2.55 | 3.89 | 0.98 | 3.55 | 2.5 | 2.92 | 2.13 | 3.43 | |||||||||||||||||||||||||||||||||||||
MPNs035-73 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs038 | 0 | 0 | 0 | 6.63 | 11.43 | 12.33 | 3.1 | 0 | 0 | 0 | 0.88 | 0 | 0 | 0 | 0 | 0 | 0 | 4.83 | 1.84 | 0 | 5.23 | 4.55 | 2.51 | 5.49 | 5.12 | 4.58 | 0 | 0 | 1.68 | 0 | |||||||||||||||||||||||||||||||||||||
MPNs053-125 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs053_60_287 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs055 | 0 | 0 | 30.25 | 33.5 | 52.08 | 50.87 | 47.13 | 42.27 | 33.5 | 39.05 | 45.6 | 32.86 | 35.7 | 35.19 | 35.86 | 30.51 | 40.02 | 60.08 | 42.66 | 46.57 | 43.11 | 42.71 | 57.32 | 50.51 | 42.98 | 41.73 | 26.2 | 25.64 | 54.33 | 48.79 | |||||||||||||||||||||||||||||||||||||
MPNs055_63_294 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs082 | 0 | 0 | 0 | 0 | 6.62 | 8.26 | 3.27 | 2.97 | 4.91 | 5.21 | 3.66 | 3.41 | 0 | 0 | 6.88 | 7.16 | 9.27 | 8.29 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.41 | |||||||||||||||||||||||||||||||||||||
MPNs082-164 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs088_102_415 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs214-319 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs256_276_789 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs261_281_828 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs298_318_200 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs330 | 0 | 0 | 9.93 | 5.55 | 2.93 | 3.49 | 13.8 | 17.36 | 6.05 | 4.49 | 13.29 | 11.58 | 13.19 | 5.97 | 5.56 | 5.05 | 6.56 | 0 | 12.42 | 9.13 | 9.15 | 10.18 | 6.57 | 10.03 | 8.67 | 11.91 | 4.52 | 0 | 9.36 | 11.6 | |||||||||||||||||||||||||||||||||||||
MPNs330-576 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs338-598 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs339-600 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs349 | 0 | 0 | 6.59 | 82 | 0 | 0 | 3.2 | 2.55 | 0 | 41.89 | 0 | 39.61 | 59.96 | 59.27 | 0 | 0 | 0 | 64 | 0 | 37.59 | 2.72 | 69.94 | 29.47 | 69.49 | 3.73 | 68.58 | 0 | 27.17 | 0 | 79.63 | |||||||||||||||||||||||||||||||||||||
MPNs349-629 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs352-643 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs356-658 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs364-668 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs365-674 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs372-682 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs378 | 0 | 0 | 7.33 | 13.28 | 9.53 | 17.55 | 11.68 | 12.93 | 11.21 | 11.16 | 11.06 | 12.99 | 11.72 | 7.52 | 5.56 | 0.73 | 11.08 | 7.89 | 15.29 | 17.26 | 10.3 | 12.45 | 0 | 12.55 | 0 | 11.85 | 6.79 | 3.17 | 0 | 8.54 | |||||||||||||||||||||||||||||||||||||
MPNs378-687 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
MPNs379-690 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||||||||||||||||||||||||||||||||||||||
0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||
0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||
0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||
0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||
0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||
0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||||||||||||||||||||||||||||||||||||||||||||
0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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TIME h | Glucose | Lactate | Acetate | Protein mg/ml | molecules glucoses/cell/s | TIME h | pH | Glucose | Lactate | Acetate | protein | molecules glucoses/cell/s | WODKE paper MSB modeling metabolism | ||||||||||||||||||||||
0 | 52.21 | 4.7315E-5 | 5.299E-6 | 0.023376 | 0 | 7.9064 | 60.317 | 0.0037048 | 0.0021653 | 0.0079953 | Time Hours | Protein in concentration mg | Glucose mM | lactate mM | acetate mM | ||||||||||||||||||||
16.839 | 59.103 | 0.52636 | 1.3715 | 0.0074101 | 3971 | 14.129 | 7.8784 | 60.836 | 0.025809 | 0.57419 | 0.0044266 | 12982 | 0 | 0.005 | 60 | 4 | 1.5 | ||||||||||||||||||
20.71 | 7.8627 | 59.603 | 0.014315 | 1.0263 | 0.0047978 | 24921 | 15 | 0.009 | 58 | 4 | 3.3 | ||||||||||||||||||||||||
30.387 | 52.495 | 0.98531 | 1.8481 | 0.018839 | 5082 | 31.161 | 7.8291 | 59.271 | 0.78443 | 1.75 | 0.011811 | 16903 | 25 | 0.013 | 57 | 4.5 | 5 | ||||||||||||||||||
38.129 | 55.492 | 1.3769 | 2.3426 | 0.023362 | 18455 | 38.903 | 7.805 | 59.887 | 1.9383 | 2.4438 | 0.014066 | 16594 | 31 | 0.02 | 55 | 5 | 5.7 | ||||||||||||||||||
48.968 | 47.746 | 5.6969 | 3.6089 | 0.037265 | 10222 | 50.71 | 7.7583 | 54.47 | 4.4025 | 3.274 | 0.018969 | 22749 | 37 | 0.021 | 52 | 7 | 6.2 | ||||||||||||||||||
57.484 | 46.477 | 9.4358 | 3.7477 | 0.043614 | 21848 | 59.806 | 7.6959 | 52.19 | 8.4369 | 3.9317 | 0.024116 | 35913 | 42 | 0.029 | 50 | 11 | 7.8 | ||||||||||||||||||
68.323 | 37.659 | 20.834 | 4.6963 | 0.055532 | 29026 | 69.677 | 7.5734 | 46.825 | 17.6 | 4.9883 | 0.031837 | 48669 | 48 | 0.031 | 48 | 15 | 8.5 | ||||||||||||||||||
76.065 | 31.028 | 34.897 | 5.551 | 0.070175 | 16729 | 78.194 | 7.3817 | 39.065 | 32.331 | 6.0332 | 0.038412 | 32017 | 52 | 0.037 | 43 | 20 | 9.2 | ||||||||||||||||||
110.9 | 15.055 | 82.097 | 7.238 | 0.06159 | -1320 | 93.097 | 6.9224 | 30.213 | 52.866 | 7.4079 | 0.042395 | 25142 | 60 | 0.042 | 33 | 25 | 10.2 | ||||||||||||||||||
129.48 | 13.129 | 80.202 | 7.3275 | 0.065479 | 3321 | 110.52 | 6.0605 | 19.325 | 73.732 | 8.7422 | 0.047348 | 10580 | 72 | 0.048 | 21 | 53 | 12.1 | ||||||||||||||||||
144.19 | 13.742 | 83.697 | 7.6564 | 0.075757 | 2157 | 134.13 | 5.0941 | 10.879 | 81.24 | 9.6941 | 0.046939 | 84 | 0.057 | 15 | 77 | 14.1 | |||||||||||||||||||
96 | 0.046 | 12 | 80 | 15.2 | |||||||||||||||||||||||||||||||
108 | 0.052 | 9 | 90 | 16.1 | |||||||||||||||||||||||||||||||
mM | molecules/ml.sec | molecules/cell.sec | 124 | 0.044 | 11 | 98 | 16.2 | ||||||||||||||||||||||||||||
time1 | time2 | dt | Dlac mM | Dace mM | D glc used | lac | ace | glc | ATP | cells/ml at t1 | lac | ace | glc | ATP | 136 | 0.048 | 10.5 | 90 | 16 | ||||||||||||||||
0 | 24 | 24 | 0.49912 | 1.3684 | 0.93376 | 3.4793978703703706E12 | 9.539205092592592E12 | 6.509301481481482E12 | 1.6273253703703707E13 | 728300000 | 4777.4239604151735 | 13097.90620979348 | 8937.665085104329 | 22344.162712760823 | 148 | 0.048 | 10.5 | 90 | 16.1 | ||||||||||||||||
24 | 48 | 24 | 4.72968 | 0.9328999999999998 | 2.83129 | 3.2970905833333332E13 | 6.50330636574074E12 | 1.9737106099537035E13 | 4.9342765248842586E13 | 2102600000 | 15681.016757030977 | 3092.983147408323 | 9386.99995221965 | 23467.499880549123 | 155 | 0.048 | 10.5 | 90 | 16.2 | ||||||||||||||||
48 | 72 | 24 | 21.2762 | 1.8657999999999997 | 11.571 | 1.4831776921296294E14 | 1.300661273148148E13 | 8.066219097222222E13 | 2.0165547743055556E14 | 3.4384E9 | 43135.693698511786 | 3782.751492403874 | 23459.222595457835 | 58648.05648864459 | 165 | 0.042 | 10.5 | 90 | 16 | ||||||||||||||||
72 | 96 | 24 | 37.405 | 1.6493000000000002 | 19.52715 | 2.6075267939814812E14 | 1.1497377199074076E13 | 1.3612502829861111E14 | 3.4031257074652775E14 | 5.1852E9 | 50287.873061434104 | 2217.3449816929096 | 26252.60902156351 | 65631.52255390877 | 180 | 0.051 | 10.5 | 90 | 16.2 | ||||||||||||||||
96 | 120 | 24 | 8.881 | -0.16129999999999978 | 4.35985 | 6.191002662037037E13 | -1.1244327546296282E12 | 3.039279693287037E13 | 7.598199233217592E13 | 4.8651E9 | 12725.334858557968 | -231.12222865503858 | 6247.106314951465 | 15617.765787378661 | |||||||||||||||||||||
120 | 144 | 24 | -7.923000000000002 | 0.03230000000000022 | -3.945350000000001 | -5.523174652777779E13 | 2.2516539351852E11 | -2.7503290567129637E13 | -6.875822641782409E13 | 5.0571E9 | -10921.6243554167 | 44.52460768395325 | 0 | -13596.374684665934 | |||||||||||||||||||||
t0 (h) | t (h) | dt | cells/ml | D lac (mM) | Total lac/ml | lac/cell.sec | D ace (mM) | Total ace/ml | ace/cell.sec | gluc /cell.sec | Produced ATP/cell.sec | D gluc (mM) | Total gluc/ml | gluc/cell.sec | Produced ATP/cell.sec (max) | Produced ATP/cell.sec (min) | ATPs for protein/cell.sec (assuming cell# of t0) | ATPs for protein prod/cell.sec assuming average cell number | Dmole ace+lac | dpH | b if pH change only by ace+lac | pH change should be (HCl) | ratio | t1/2 | k | 0.014926600860541634 | t0 (h) | dt | 1.4926600860541635E9 | Dcells/ml | |||||
18.25 | 26.75 | 8.5 | 1.4926600860541635E9 | 0 | 0 | 0 | 0.45211269575024504 | 2.72307476650372544E17 | 5961.797483954494 | 2980.898741977247 | 10433.145596920365 | 1.2326388888888857 | 7.4241840277777587E17 | 16254.229300523331 | 56889.80255183166 | 39010.15032125599 | 381.9353581195087 | 402.1644842165756 | 4.5211269575024506E-7 | 0.04369461514422124 | 1.0347103281673794E-5 | 0.0054255693717778115 | 8.05346170145894 | 20 | 0.03465735902799726 | 0.01529781489918164 | 18.25 | 8.5 | 1.529781489918164E9 | 3.712140386400056E7 | 2.4869294898968413 | ||||
26.75 | 40.25 | 13.5 | 1.529781489918164E9 | 0.7701149425287368 | 4.6384022988505818E17 | 6238.824116290289 | 0.7237473871076312 | 4.3591305125492627E17 | 5863.193146159066 | 6051.008631224677 | 21178.530209286368 | 0.33203125 | 1.99982421875E17 | 2689.8381728058894 | 9414.433604820613 | 6455.6116147341345 | 2134.254247000957 | 2114.627172171829 | 1.493862329636368E-6 | 0.033569603109482316 | 4.450044657258402E-5 | 0.017927065038237947 | 1.872565477833614 | 0.02231080739053404 | 26.75 | 13.5 | 2.2310807390534043E9 | 7.012992491352403E8 | |||||||
40.25 | 50.25 | 10 | 2.2310807390534043E9 | 1.1538461538461529 | 6.9496153846153779E17 | 8652.527379030491 | 0.6937696846830539 | 4.1785748108460333E17 | 5202.479699266616 | 6927.5035391485535 | 24246.26238701994 | -0.61631944444445 | -3.7120920138889222E17 | -4621.691418313208 | -16175.919964096227 | -11092.059403951698 | 3869.629989390979 | 3781.097550306212 | 1.8476158385292067E-6 | 0.024081764061146593 | 7.672261192485236E-5 | 0.022172276953428615 | 1.0861204788181533 | 0.024565510841137266 | 40.25 | 10 | 2.4565510841137266E9 | 2.2547034506032228E8 | |||||||
50.25 | 65.5 | 15.25 | 2.4565510841137266E9 | 2.4641909814323615 | 1.48418222811671117E18 | 11004.975569194396 | 0.8301988202071469 | 5.0002874941076448E17 | 3707.633784392389 | 7356.304676793392 | 25747.066368776872 | 5.4166666666666785 | 3.2624583333333407E18 | 24190.610542080125 | 84667.13689728043 | 58057.4653009923 | 2381.429450550757 | 2349.445435853442 | 3.2943898016395085E-6 | 0.04676281607554689 | 7.044891813866197E-5 | 0.039534258990033704 | 1.182842862625437 | 0.029469332658398722 | 50.25 | 15.25 | 2.9469332658398724E9 | 4.9038218172614574E8 | |||||||
65.5 | 77.25 | 11.75 | 2.9469332658398724E9 | 4.0344827586206895 | 2.4299689655172408E18 | 19493.510593138897 | 0.6576740838044817 | 3.961171006754393E17 | 3177.700212519589 | 11335.605402829244 | 39674.618909902354 | 2.2808159722222214 | 1.37373546006944384E18 | 11020.27520640952 | 38570.96322243332 | 26448.660495382846 | 2858.287120339971 | 2791.690866600189 | 4.692156842425171E-6 | 0.062306606109505225 | 7.530753374976969E-5 | 0.056308134434479434 | 1.1065293981992186 | 0.03461570910318063 | 65.5 | 11.75 | 3.4615709103180633E9 | 5.146376444781909E8 | |||||||
77.25 | 90 | 12.75 | 3.4615709103180633E9 | 9.163351016799295 | 5.5190863174182144E18 | 34736.11694952898 | 1.0565610630049687 | 6.3636672824789261E17 | 4005.175462729206 | 19370.64620612909 | 67797.26172145182 | 5.364583333333329 | 3.2310885416666639E18 | 20335.87862240922 | 71175.57517843226 | 48806.108693782124 | 2711.804760000786 | 2643.290350617124 | 1.0219912079804264E-5 | 0.12252135998098801 | 8.341330916821457E-5 | 0.12264385071167963 | 0.9990012484932523 | 0.04233738294102758 | 77.25 | 12.75 | 4.2337382941027584E9 | 7.721673837846951E8 | |||||||
90 | 101 | 11 | 4.2337382941027584E9 | 14.730327144120249 | 8.8720760389036268E18 | 52918.3215048531 | 1.0449370559423796 | 6.293655887940951E17 | 3753.909505042157 | 28336.11550494763 | 99176.4042673167 | 7.760416666666671 | 4.6740989583333356E18 | 27879.097331671237 | 97576.84066084932 | 66909.83359601097 | 2999.89701503653 | 2929.9461102017085 | 1.5775264200062632E-5 | 0.19176946261276306 | 8.226160716692086E-5 | 0.18931074283046478 | 1.0129877456796001 | 0.04891166793216907 | 90 | 11 | 4.891166793216907E9 | 6.574284991141481E8 | |||||||
101 | 120.25 | 19.25 | 4.891166793216907E9 | 20.53492484526968 | 1.2368185234305927E19 | 36488.85817012686 | 1.3746917826127145 | 8.2797686066763789E17 | 2442.7132731848797 | 19465.78572165587 | 68130.25002579554 | 8.851996527777779 | 5.3315575086805555E18 | 15729.263596450088 | 55052.4225875753 | 37750.23263148021 | 2437.868569263136 | 2421.871629373696 | 2.190961662788239E-5 | 0.45927144532222464 | 4.770515748591906E-5 | 0.26292591657125153 | 1.7467713008723675 | 0.05289483675018983 | 101 | 19.25 | 5.289483675018983E9 | 3.9831688180207634E8 | |||||||
120.25 | 142.75 | 22.5 | 5.289483675018983E9 | 20.866489832007062 | 1.256788682581785E19 | 29333.505148681335 | 1.334313652816352 | 8.0365711309128883E17 | 1875.7393658423262 | 15604.622257261832 | 54616.17790041641 | 10.88758680555556 | 6.557593532986113E18 | 15305.453202176652 | 53569.08620761828 | 36733.08768522396 | 2224.9798048941143 | 2216.213893288781 | 2.2200803484823415E-5 | 0.8618702078475984 | 2.5758870979270592E-5 | 0.35521285575717465 | 2.426348579108796 | 0.05784822407829241 | 120.25 | 22.5 | 5.784822407829241E9 | 4.953387328102579E8 | |||||||
142.75 | 173.25 | 30.5 | 5.784822407829241E9 | 13.187444739168882 | 7.9427979664014172E18 | 12504.92654629627 | 0.9519449994416487 | 5.7335647316370496E17 | 902.6769423173403 | 6703.801744306806 | 23463.306105073818 | 8.446180555555554 | 5.0871345486111099E18 | 8009.047206110567 | 28031.665221386982 | 19221.71329466536 | 2193.395840676057 | 2193.979316583323 | 1.4139389738610532E-5 | 0.9664560821712032 | 1.4630142020365293E-5 | 0.6787993153437605 | 1.423772918335615 | 0.05743904496751878 | 142.75 | 30.5 | 5.743904496751878E9 |