Selected Cell
Cell:
Value:
Fucose_Metabolome
Glucose_Metabolome
Tabelle3
A
B
C
D
E
F
G
H
I
J
K
L
M
N
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
| normalised peak area | ND | not detected | |||||||||||
| Cultivation 1 | Cultivation 2 | Cultivation 3 | NA | not available (compound found on only one condition) | |||||||||
| Metabolites | Fuc:1 | Fuc:2 | Fuc:3 | Fuc:4 | Fuc:5 | Fuc:6 | Fuc:7 | Fuc:8 | Fuc:9 | p-value adjusted | |||
| 1-O-methyl-, alpha-mannopyranoside | 2078.4155 | 2779.7799 | 2079.5334 | 1961.9077 | 2223.2529 | 3221.3786 | 1729.1348 | 1456.6174 | 1774.4953 | NA | |||
| 1-O-methyl-alpha-glucopyranoside | 76744.6446 | 31760.0382 | 37031.2245 | 27818.0407 | 60294.1391 | 41282.4364 | 45007.9476 | 34192.8119 | 35402.3585 | 0.00994000129801594 | |||
| 2,7-anhydro-β sedoheptulose | 4442.0778 | 4420.6439 | 3916.4474 | 4056.5542 | 4859.4168 | 4081.8794 | 3428.6052 | 2810.0316 | 2796.6208 | NA | |||
| 2-aminobutanoate | 20645.8035 | 19343.3508 | 21065.7957 | 23255.0966 | 18192.4627 | 36863.5132 | 19754.5747 | 17991.1675 | 14806.9978 | 0.00770233886126184 | |||
| 2-aminoadipic-acid | 17608.9012 | 12938.3294 | 15623.1375 | 12743.889 | 14914.2453 | 15535.2378 | 10518.0112 | 12746.5354 | 19648.4845 | NA | |||
| 2-methyl-malate | 15460.9465 | 11072.785 | 12099.1207 | 9568.8217 | 8705.4454 | 14059.3236 | 7533.7336 | 8091.3332 | 11997.003 | 0.0200650446360383 | |||
| 3-hydroxybutanoate | ND | 2352.3895 | 2189.2203 | 1963.7055 | 1993.7277 | 2936.3602 | 2112.4978 | 2000.4396 | ND | 0.0245644048581384 | |||
| 4-hydroxyphenylacetate | 8621.6376 | 6399.0769 | 9009.9324 | 4675.9086 | 4446.5458 | 7051.1564 | 3547.1499 | ND | 4364.6203 | 0.00914319169338808 | |||
| 5-methylthio-adenosine | 7866.6115 | 2688.4882 | 4211.5745 | 3684.2454 | 2510.9972 | ND | ND | ND | 2103.2493 | 0.18089779089704 | |||
| adenosine | 6771.2408 | 5793.442 | 5377.0123 | 5867.8669 | 7798.4881 | 6235.2461 | 4606.6509 | 3856.6534 | 5648.7601 | 1 | |||
| alanine | 74239.4888 | 84270.2187 | 99365.0733 | 107904.7507 | 110477.736 | 211491.6201 | 66995.1117 | 87643.1013 | 60564.8646 | 0.046493455172801 | |||
| D228685_2290.54 | 36392.4484 | 35583.9262 | 28237.3445 | 24194.3922 | 35694.4032 | 29382.32 | ND | ND | ND | NA | |||
| fuconate | 22563.3402 | 22697.4556 | 20964.7797 | 24194.356 | 24780.3352 | 31566.2511 | 18064.6185 | 16373.8432 | 16396.615 | NA | |||
| fuconolactone | 19951.2171 | 21440.0699 | 19070.8657 | 16631.7341 | 21372.4836 | 31160.2284 | ND | 16282.4528 | 22274.2923 | NA | |||
| fucose | 198087.3481 | 415594.7418 | 261819.8952 | 193453.7946 | 348141.459 | 420600.9102 | 272050.3816 | 354105.896 | 301601.5684 | NA | |||
| glucopyranose_[-H20]_(4TMS)_1763.61 | 85970.4127 | 105421.4297 | 85358.444 | 94175.5911 | 97408.2482 | 103879.4055 | 94930.4572 | 88736.6904 | 84086.4594 | 1 | |||
| glucose | 13848.488 | 12251.3062 | 9596.6371 | 5264.1346 | 11707.7406 | 19942.3853 | 14240.8989 | 10819.3786 | 9049.0222 | 0.00770233886126184 | |||
| glucose-6-phosphate | 2129.7726 | 2457.9705 | 2048.2525 | 2209.7434 | 2070.9683 | 1553.6125 | 2617.4595 | 2426.8592 | 2551.8656 | 0.00770233886126184 | |||
| glutamate | 85940.0018 | 76769.7496 | 84316.87 | 76949.4853 | 69795.2374 | 88673.6204 | 64723.0329 | 62027.0235 | 81772.0086 | 0.0171655296269177 | |||
| glycerol-2-phosphate | ND | 156483.7972 | 82520.968 | 100269.564 | 146030.3152 | ND | 182051.9153 | 143899.8699 | ND | 0.85668616699632 | |||
| glycerol-3-phosphate | 715047.2226 | 958294.2707 | 779313.6553 | 696070.4037 | 757347.5554 | 892065.1502 | 882645.0167 | 869906.4715 | 645681.2181 | 1 | |||
| glycine | 116629.5199 | 153938.8355 | 133235.3395 | 182547.4914 | 209236.9454 | 259406.7002 | 197937.6085 | 177800.4661 | 151612.8393 | 0.426213538483146 | |||
| glycolate | 1257.5391 | 1698.626 | 1329.9384 | 1538.3738 | 1642.3426 | 2175.418 | 1490.0984 | 1426.1124 | 1255.5618 | 1 | |||
| isoleucine | 24360.6299 | 36531.7311 | 32906.1029 | 33166.0658 | 30362.7106 | 52186.4426 | 33006.2675 | 32541.0225 | 23924.8139 | 0.426213538483146 | |||
| lactate | 45509.7318 | 61796.59 | 65492.1919 | 61590.0348 | 75247.1066 | 88164.3423 | 55916.0551 | 100732.2352 | 44035.2403 | 1 | |||
| myo-inositol | 6437.9343 | 8404.4273 | 6774.1486 | 5614.7813 | 7441.0855 | 7930.1395 | 7204.7573 | 6477.9497 | 6284.3501 | 0.00770233886126184 | |||
| myo-inositol-2-phosphate | 2637.0065 | 2967.9706 | 2945.3941 | 2601.4704 | 2556.3646 | 1925.6664 | 2728.3738 | 2556.3647 | 2532.591 | 1 | |||
| NA_2615.1 | 2509.5121 | 5901.1219 | 3099.6067 | 3508.4454 | 4658.4248 | 4672.2971 | 7779.1961 | 5103.9166 | 3790.6809 | 1 | |||
| NA213001368 | 3060.5908 | 3779.5865 | 3316.5393 | 3287.2574 | 3888.3758 | 4617.1229 | 1303.9066 | 1125.5816 | 1086.4261 | NA | |||
| NA226 | 14473.6216 | 12897.4313 | 12754.333 | 11354.6326 | 8863.5687 | 16266.2511 | 11936.2091 | 11870.06 | 15050.8922 | 0.426213538483146 | |||
| NA342 | 5541.4835 | 6968.7238 | 5845.5572 | 5567.4946 | 6309.6442 | 7614.5102 | ND | ND | ND | NA | |||
| NA363 | 4241.6108 | 5452.6374 | 4830.1569 | 4386.0746 | 4960.4821 | 6202.1302 | 2143.6191 | 1991.9217 | 2108.5391 | NA | |||
| NA374 | 21573.3784 | 26631.321 | 24142.2876 | 20888.2237 | 26908.1623 | 32700.0169 | 4010.1982 | 3360.3471 | 8492.3617 | NA | |||
| NA375 | 3387.6945 | 5101.0624 | 3904.2942 | 3588.5046 | 4113.0387 | 5080.2256 | 2243.3245 | 2043.6732 | 2550.1222 | NA | |||
| NA454 | 12327.0305 | 12926.5211 | 11083.5718 | 11656.5643 | 13059.1374 | 11769.5897 | 11910.9694 | 9430.4998 | 8614.0805 | 0.011489780604121 | |||
| NA464 | 7373.8473 | 10046.6672 | 7609.4625 | 6891.212 | 8319.0438 | 9500.2642 | ND | ND | ND | NA | |||
| NA468 | 100699.8595 | 136322.3905 | 107197.7675 | 101234.2623 | 123714.2266 | 149271.7509 | ND | ND | ND | NA | |||
| NA547 | 25415.4057 | 34772.4781 | 25390.1264 | 30055.0622 | 37385.8962 | 40835.5186 | 41204.9111 | 34181.585 | 31856.0304 | 0.011489780604121 | |||
| NA606 | 12883.5646 | 14579.963 | 11446.6511 | 13754.166 | 17239.0256 | 14751.2442 | 31983.8469 | 26217.8521 | 25308.0661 | NA | |||
| nicotinamide | 38514.2422 | 16530.6318 | 38111.9978 | 34933.864 | 31523.902 | 35550.2537 | 21110.2005 | 39098.3598 | 54766.5494 | 0.847045370178886 | |||
| proline | 5523.2822 | 12091.8686 | 10424.348 | 10105.2143 | 9453.9147 | 20968.0907 | ND | 9821.9791 | ND | 0.250458467384304 | |||
| propane-1,3-diamine | 4670.2098 | 5714.6502 | 5022.4645 | 4881.1759 | 6167.3781 | 7518.5507 | 6492.849 | 6034.2923 | 5783.0357 | 0.0748124591481107 | |||
| putrescine | 800025.9464 | 998721.7591 | 856933.8083 | 667804.5362 | 936659.3889 | 1066864.1703 | 857556.0878 | 794125.8155 | 736074.0591 | 0.00770233886126184 | |||
| pyroglutamate | 21780.7932 | 13806.5966 | 27099.2061 | 20909.0597 | 25884.1863 | 25625.2718 | 16171.7902 | 25902.8146 | 27729.8183 | 0.308989102996587 | |||
| pyruvate | 8334.3482 | 12825.6879 | 11170.0791 | 11789.416 | 11735.3787 | 15812.9419 | 9881.1961 | 9470.8174 | 9148.6531 | 0.00994000129801594 | |||
| ribulose | 7109.7256 | 9810.9602 | 8772.1638 | 8258.7691 | 9877.1798 | 11605.6026 | 9563.7279 | 9364.18 | 9126.8963 | 0.00994000129801594 | |||
| similar to inositol (6TMS)317 | 8318.0211 | 10997.0168 | 8911.9313 | 7955.9742 | 9399.5746 | 11316.065 | 10113.9207 | 9257.3361 | 9049.394 | 0.00770233886126184 | |||
| spermidine | 135784.735 | 14144.7 | 31109.7886 | 60079.8949 | 34862.3477 | 6658.7253 | 12099.6308 | 10776.4475 | 34976.5269 | 1 | |||
| succinate | 934.9403 | 469.277 | 546.703 | 432.4884 | 431.9152 | 446.2535 | 592.4398 | 541.9901 | 1323.7219 | 0.0591670464363884 | |||
| threonine | 1820.8534 | 5409.1909 | 5170.7377 | 5738.7396 | 5635.6357 | 8852.8885 | 4750.9796 | 4268.0105 | 1063.7873 | 1 | |||
| trehalose | 1193692.1179 | 1624979.5689 | 1189305.9937 | 1273070.2876 | 1567401.3757 | 1740917.8775 | 2039192.5279 | 1704010.526 | 1629704.3748 | 0.00770233886126184 | |||
| unidentified metabolite_1687.88 | 11858.0025 | 13703.9854 | 10819.5715 | 10440.7469 | 11810.6632 | 14648.3626 | 11195.1684 | 10310.4298 | 11773.3515 | 0.00770233886126184 | |||
| Unknown_bth-pae-014_1178.4 | 2798.6436 | 3787.107 | 3715.5412 | 2824.2944 | 3185.8916 | 4578.8518 | 4017.8475 | 3945.4823 | 3705.4267 | 0.0135307578908814 | |||
| Unknown_bth-pae-025_1411.4 | 26917.5672 | 11332.4552 | 5215.2657 | 8923.7127 | 13073.6157 | 7140.4949 | 23522.6268 | 11961.133 | 44767.1597 | 1 | |||
| Unknown_Sso_003 | 8772.2643 | 9520.2099 | 8979.2289 | 8065.7975 | 8634.1447 | 10349.6721 | 7944.2382 | 7927.7919 | 7819.6547 | 0.00770233886126184 | |||
| Unknown_Sso_004 | 14229.0487 | 11695.2182 | 13039.886 | 11865.4493 | 11521.8476 | 18899.4908 | 24365.2669 | 18926.8522 | 22225.3696 | NA | |||
| Unknown_Sso_005 | 1558.6706 | 2092.2307 | 1840.4948 | 1685.1237 | 1994.6633 | 2603.3899 | 1742.7656 | 1815.7301 | 1852.1083 | 0.011489780604121 | |||
| Unknown_Sso_006 | 9210.49 | 11517.5281 | 9904.0094 | 9822.1359 | 11184.5906 | 13295.7537 | 11688.2365 | 11229.402 | 11336.9242 | NA | |||
| Unknown_Sso_007 | 312917.2031 | 431398.2422 | 352380.5418 | 273293.1264 | 331402.1178 | 380098.5604 | 10723.7704 | 9941.022 | 10193.0518 | NA | |||
| Unknown_Sso_008 | 77386.8574 | 93254.3355 | 87620.2571 | 72411.0528 | 31448.7556 | 81618.7395 | 28064.0008 | 37940.4845 | 66983.5341 | 0.0894025449190997 | |||
| Unknown_Sso_009 | 14729.0965 | 11540.8336 | 8708.7815 | 10448.7546 | 16666.6304 | 10898.2581 | ND | ND | ND | NA | |||
| Unknown_Sso_010 | 11713.8384 | 19601.8036 | 14363.4929 | 26623.1061 | 25772.6075 | 21386.7455 | 21704.2594 | 19005.7269 | 26430.0654 | 0.046493455172801 | |||
| Unknown_Sso_011 | 9926.2927 | 18045.7184 | 12126.6973 | 11916.7315 | 15701.2925 | 20546.3025 | ND | ND | ND | NA | |||
| Unknown_Sso_012 | 12798.7479 | 18126.2194 | 12931.9606 | 14354.8782 | 16846.2681 | 16711.3502 | ND | ND | ND | NA | |||
| Unknown_Sso_019 | 41552.5202 | 53499.4094 | 42317.9787 | 44230.2008 | 50208.4396 | 51909.0816 | ND | ND | ND | NA | |||
| valine | 30556.871 | 52195.4247 | 50938.387 | 44620.3564 | 44278.7975 | 67603.8171 | 54658.2253 | 52108.8501 | 29911.1265 | 0.011489780604121 | |||
| normalised peak area | |||||||||||||
| Cultivation 1 | Cultivation 2 | Cultivation 3 | |||||||||||
| Coenzyme A derivatives | Fuc:1 | Fuc:2 | Fuc:3 | Fuc:4 | Fuc:5 | Fuc:6 | Fuc:7 | Fuc:8 | Fuc:9 | p-value adjusted | |||
| (S)-2-Methylbutanoyl-CoA | 10406.2982799764 | 3415.1735793784446 | 3512.726987024048 | 908.5387790717691 | 3276.194950448975 | 2474.329362622875 | 3688.8287794969688 | 3799.264878425511 | 4277.659991713478 | 0.0217091395047538 | |||
| 3-Hydroxy-2-methylbutyryl-CoA | 326889.3001901474 | 294715.84846930334 | 337542.3241881249 | 327321.3126022854 | 328847.9493573912 | 275816.3414086423 | 331362.6867177 | 343637.0697483895 | 329057.3592584779 | 0.00770233886126184 | |||
| 3-Hydroxybutanoyl-CoA | 28944.088151487766 | 25428.810027663014 | 26283.40253136678 | 26324.413107395278 | 26405.098360938966 | 22792.88383414435 | 17800.590166666592 | 15853.55162787595 | 17574.52725295213 | 0.409589617458569 | |||
| Acetoacetyl-CoA | 24662.89812932816 | 21610.21867506272 | 17989.103446705765 | 50828.264073950144 | 38507.74848046946 | 39486.85477080165 | 21346.15899247682 | 19697.280320641 | 17477.717547547694 | 0.00770233886126184 | |||
| Acetyl-CoA | 743381.3640330086 | 650649.9760000027 | 669251.3344266204 | 873156.6328002237 | 867352.3370980741 | 791993.1535412414 | 706703.5925538923 | 703423.0266273376 | 739326.9645483303 | 0.00844451171247201 | |||
| Benzoyl-CoA | 3489.0447752133073 | 3499.9391936023158 | 3813.6475920091493 | 3077.6311147353354 | 3494.72493394235 | 3019.831618655577 | 5064.412282059632 | 4800.689577530722 | 5175.838991954708 | 0.0894025449190997 | |||
| Beta-methylcrotonyl-CoA | 30923.31135438497 | 31371.813324684368 | 29488.841191925694 | 27779.890268174648 | 26926.33840259734 | 22424.390622155897 | 29054.417689251484 | 29788.906865431843 | 25457.325589266235 | 0.0894025449190997 | |||
| β-Hydroxy-β-methylglutaryl CoA | 215723.91778562288 | 198569.71283262075 | 201117.1684848489 | 267446.2327736608 | 280729.78581659845 | 249926.66529849797 | 229291.28358333916 | 219436.9030051869 | 272987.6992516693 | 0.012847551828305 | |||
| Butanoyl-CoA | 5232.559130208171 | 3694.7685105667574 | 5847.749602614618 | 3003.9291333597166 | 3040.579308394216 | 2539.6587174671813 | 3404.5882196366656 | 3451.2893896914106 | 4014.794313944392 | 1 | |||
| CoenzymeA | 15474.178465277528 | 27482.693693220943 | 17575.14232784638 | 25756.605858456624 | 27946.027425847446 | 22729.70832705397 | 26568.4288109738 | 17761.988648755123 | 28370.898237717607 | 0.505245237778958 | |||
| Crotonoyl-CoA | 3549.357023974526 | 1917.2723578297566 | 2260.4942298349997 | 1960.3111649532589 | 2609.2016040032086 | 2621.5596700163583 | 1518.7732067799188 | 836.0028855109091 | 1250.1003566939146 | 0.209742706014445 | |||
| Cyclohexa-1,5-dienecarbonyl-CoA | 735.1113377392412 | 751.9062929907934 | 747.2968636238763 | 627.9934599236042 | 740.2822773856765 | 792.1426146973045 | 721.805387157122 | 709.8432333661174 | 1016.7626460248835 | 0.00885779322538958 | |||
| Glutaryl-CoA | 1463.1467377487425 | 1019.9031456888331 | 1101.6275670990221 | 1034.9519762685254 | 1421.8817446718344 | 973.3239509143566 | 1917.9768636658355 | 1567.3684932075864 | 2017.3649611351468 | 0.0135307578908814 | |||
| Hexanoyl-CoA | 1782.9067480866731 | 1268.0656130265431 | 1341.6055788344656 | 789.3618839271155 | 803.1967443229544 | 655.6133950717999 | 489.6165848063904 | 611.6998421572026 | 903.795374383986 | 0.00885779322538958 | |||
| Isobutanoyl-CoA | 10920.949714486664 | 9834.414329283887 | 9163.685915186268 | 10884.67195147481 | 10355.833860325003 | 9841.043752877596 | 9803.370047626804 | 9025.62607219308 | 8393.473706468094 | 0.00770233886126184 | |||
| Isovaleryl-CoA | 26664.48149816776 | 22609.270714083814 | 25112.70763150535 | 25176.34752826528 | 27650.805048095834 | 21464.797447024328 | 28946.191323903873 | 844.024101970337 | 26308.01277947512 | 0.00770233886126184 | |||
| Malonyl-CoA | 50139.50790907952 | 47520.11791419338 | 43363.32925640678 | 21222.458975178306 | 33966.51946097349 | 35670.47052572892 | 22529.5502765301 | 22222.45441470489 | 24274.38152245477 | NA | |||
| Methylmalonyl-CoA | 19449.73875970585 | 19039.119314937707 | 17828.002381574464 | 26245.00868923461 | 28600.478974315105 | 24812.400031633046 | 22284.333530291555 | 21929.0860285715 | 20867.887934650997 | 0.159216529165329 | |||
| Pentanoyl-CoA | 4072.7483414689873 | 3794.7839282363902 | 3847.6550006055163 | 3672.4761894175563 | 3661.2868179289894 | 3176.979945221007 | 3866.4956135621997 | 3885.7107413838567 | 4019.708980764676 | 0.209742706014445 | |||
| Phenylacetyl-CoA | 1889.0154293600042 | 1877.1325975987352 | 1511.8143122979554 | 1717.6393749999927 | 1717.639374999999 | 1518.0418489310093 | 1339.4051559789195 | 1692.9765936121719 | 1923.2839334975079 | 0.0135307578908814 | |||
| Propanoyl-CoA | 90156.23590476761 | 78398.20069833867 | 88418.70477702744 | 104605.16637976408 | 109872.42041682256 | 97540.62755382856 | 81198.74230229302 | 78131.48906654619 | 92695.0960335727 | 0.00770233886126184 | |||
| Succinyl-CoA | 32042.569835669296 | 25352.724484516675 | 22629.423590529135 | 35046.939332486436 | 24004.395703978775 | 22575.945277650266 | 34987.72121396609 | 32197.764476408738 | 32503.16146643448 | 0.0171655296269177 |
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| normalised peak area | ND | not detected | |||||||||||
| Cultivation 1 | Cultivation 2 | Cultivation 3 | NA | not available (compound found on only one condition) | |||||||||
| Metabolites | Glc:1 | Glc:2 | Glc:3 | Glc:4 | Glc:5 | Glc:6 | Glc:7 | Glc:8 | Glc:9 | p-value_adjusted | |||
| 1,6-anhydro-glucose | 2727.0991 | 2086.3279 | 2444.1437 | 2881.4671 | 2888.814 | 2391.3231 | 2662.5591 | 3232.1192 | 2516.2465 | NA | |||
| 1-O-methyl-, alpha-galactopyranoside | 6679 | 9807.5943 | 4406.5433 | 9036.3634 | 7006.1528 | 8657.8797 | 18476.8747 | 8205.2712 | 11971.3342 | NA | |||
| 1-O-methyl-alpha-glucopyranoside | 425193.4477 | 505565.9081 | 55674.6748 | 245807.7561 | 185155.9666 | 222322.6887 | 666286.5234 | 388797.0467 | 647691.2618 | 0.00994000129801594 | |||
| 2-aminobutanoate | 8437.4908 | 9751.7468 | 8435.3346 | 8683.4425 | 9102.4236 | 9843.9809 | 11591.6495 | 10298.3592 | 8823.5483 | 0.00770233886126184 | |||
| 2-methyl-malate | 8767.9284 | 3770.2851 | 4980.1579 | 7889.2064 | 3208.6796 | 3512.0608 | 4317.8412 | 7125.9926 | ND | 0.0200650446360383 | |||
| 3-hydroxybutanoate | ND | 555.4077 | 557.3521 | ND | 479.4149 | 500.8748 | 507.8487 | ND | 385.9487 | 0.0245644048581384 | |||
| 4-hydroxyphenylacetate | 11080.577 | 10844.1195 | 10966.7879 | 26132.8605 | 25935.8381 | 26408.8403 | 12114.81 | 18529.9068 | 13864.9834 | 0.00914319169338808 | |||
| 5-methylthio-adenosine | 6589.6939 | 5005.5922 | 4231.0586 | 7409.8186 | 8314.8028 | 6675.9746 | 6731.7586 | 7862.9465 | 7006.8397 | 0.18089779089704 | |||
| adenosine | 7968.9083 | 6294.9309 | 4018.3666 | 4831.0346 | 5953.6633 | 4885.2921 | 6223.3343 | 6904.5317 | 6914.6241 | 1 | |||
| alanine | 59011.4857 | 78828.5198 | 72646.9077 | 59699.7159 | 59641.6702 | 61060.0048 | 63415.6612 | 49637.8094 | 72701.9944 | 0.046493455172801 | |||
| D226501_2270.9 | 1892.6754 | 2168.0216 | 1182.1029 | 1580.5567 | 1717.6444 | 1976.9022 | 1995.6878 | 1350.145 | 2004.656 | NA | |||
| erythritol | 13156.6697 | 11884.1241 | 13286.4697 | 13394.4775 | 13691.5438 | 14363.8421 | 15074.8592 | 14221.2124 | 14186.8552 | NA | |||
| erythronic acid | 4673.1583 | 4015.9351 | 4380.806 | 5441.749 | 4853.6804 | 5146.7546 | 4744.8188 | 5250.1665 | 4176.4829 | NA | |||
| fructose-6-phosphate | 4257.9275 | 3652.2128 | 4104.201 | 3652.2128 | 3728.2034 | 3741.1449 | 3337.9772 | 3652.39 | 3739.7653 | NA | |||
| galactose | 4322.3047 | 2823.1176 | 3498.0694 | 1672.4899 | 2062.5504 | 2020.0865 | 1970.5081 | 2401.3877 | 2429.3563 | NA | |||
| gluconic-acid | 27523.6635 | 13928.6727 | 9591.7742 | 10565.9479 | 15758.0683 | 7762.2492 | 13244.1501 | 18345.8832 | 21137.7778 | NA | |||
| glucopyranose_[-H20]_(4TMS)_1763.61 | 93578.9444 | 78837.9282 | 101112.537 | 92500.1478 | 88323.2719 | 91321.4864 | 87851.0199 | 108314.0249 | 94873.1935 | 1 | |||
| glucose | 1405339.6457 | 1155576.1726 | 1391540.7062 | 826288.2886 | 1083390.7817 | 1035333.9839 | 806582.7213 | 943043.5094 | 1019247.875 | 0.00770233886126184 | |||
| glucose-6-phosphate | 14576.217 | 11504.2773 | 12034.2783 | 10706.5985 | 10695.1679 | 9762.5309 | 9473.5685 | 10840.3112 | 11718.3968 | 0.00770233886126184 | |||
| glutamate | 57718.1213 | 31106.3254 | 25440.7739 | 70165.5656 | 43004.9697 | 43282.2991 | 51553.0484 | 68757.0744 | 33256.0233 | 0.0171655296269177 | |||
| glycerate | 1909.6652 | 992.8307 | 837.6734 | 1792.3146 | 965.3989 | 970.2657 | ND | 2218.9689 | ND | NA | |||
| glycerol-2-phosphate | ND | 89114.9854 | 117747.2003 | ND | 107289.5035 | 111760.1826 | 90991.8964 | ND | 96807.9302 | 0.85668616699632 | |||
| glycerol-3-phosphate | 744929.293 | 648518.4248 | 820278.5505 | 809112.4001 | 737518.8606 | 758315.1469 | 741434.2753 | 809485.4057 | 702951.7171 | 1 | |||
| glycine | 118849.1027 | 115294.2559 | 123242.3182 | 151505.0467 | 158890.9657 | 170144.612 | 160801.9693 | 143682.6335 | 143395.8975 | 0.426213538483146 | |||
| glycolate | 1431.3485 | 1506.6816 | 1277.6982 | 1496.0278 | 1444.6031 | 1615.2103 | 1620.24 | 1415.0111 | 1207.9032 | 1 | |||
| isoleucine | 19576.6685 | 27911.422 | 28461.2115 | 23941.8359 | 28545.5401 | 30861.0873 | 37055.4701 | 19117.2186 | 28558.3506 | 0.426213538483146 | |||
| isomaltulose | 10995.9927 | 18652.8414 | 31591.1317 | 22894.256 | 11729.6512 | 22435.008 | 15267.5236 | 14142.2376 | 9728.6262 | NA | |||
| lactate | 34144.2065 | 47172.5391 | 76996.9036 | 40446.9159 | 65556.0881 | 71625.1492 | 70922.8687 | 39225.4888 | 54015.2783 | 1 | |||
| leucine | 21195.4077 | 8738.8201 | 9876.4088 | 16873.3017 | 10188.472 | 10799.205 | 8583.7913 | 24426.1596 | 9332.963 | NA | |||
| myo-inositol | 11540.3755 | 11213.8567 | 10196.415 | 11065.6988 | 10344.5732 | 10421.0945 | 12959.7372 | 12461.1012 | 12739.9586 | 0.00770233886126184 | |||
| myo-inositol-2-phosphate | 2954.5687 | 2419.8177 | 2884.4786 | 2556.3646 | 2928.5828 | 2691.1902 | 2685.09 | 3368.2672 | 2974.6741 | 1 | |||
| NA_2615.1 | 3666.9254 | 4414.7714 | 7574.0085 | 5995.918 | 4044.3556 | 5883.0803 | 5283.0004 | 4024.7806 | 3775.2193 | 1 | |||
| NA192001_1915,94 | 4344.3259 | 2469.5944 | 4236.9724 | 1707.7242 | 1816.1297 | 2020.0865 | 2309.9804 | 2083.162 | 2267.7408 | NA | |||
| NA226 | 19503.8744 | 12535.2809 | 14437.111 | 16284.8298 | 13694.7886 | 13697.0507 | 14441.5472 | 18532.8923 | 14462.7614 | 0.426213538483146 | |||
| NA235 | 16893.929 | 25686.4347 | 45116.5312 | 24909.0675 | 26117.5518 | 33775.8859 | 23112.8229 | 16777.6238 | 18371.744 | NA | |||
| NA283 | 14164.2939 | 8591.9283 | 9094.2342 | 5538.9967 | 6258.7459 | 4867.3974 | 5207.1259 | 6832.4498 | 6844.9743 | NA | |||
| NA289 | 1476.973 | 2006.314 | 2267.3066 | 1729.8312 | 1590.9587 | 1710.4871 | 1911.6773 | 1788.5011 | 1186.7945 | NA | |||
| NA321 | 28481.7433 | 20728.912 | 20559.0861 | 8863.6268 | 15188.1568 | 14668.4849 | 10735.9027 | 16865.133 | 17606.3342 | NA | |||
| NA454 | 7704.3411 | 6279.1497 | 5311.4616 | 7145.7922 | 7218.5923 | 6065.0865 | 8652.8906 | 8656.3402 | 8629.3775 | 0.011489780604121 | |||
| NA540 | 11668.2398 | 11579.2357 | 12514.2161 | 12582.423 | 11635.9799 | 12582.423 | 13323.7454 | 13279.8065 | 12091.2391 | NA | |||
| NA547 | 52574.1104 | 51980.795 | 56396.7043 | 41041.5958 | 38926.8937 | 41565.4377 | 51306.0607 | 47917.2881 | 43626.1215 | 0.011489780604121 | |||
| NA653 | 18511.8349 | 20612.095 | 22744.679 | 24114.6308 | 20255.3291 | 20785.0444 | 19544.0433 | 21791.0966 | 21364.3141 | NA | |||
| NA820 | 3872.3958 | 3707.5271 | 4029.1176 | 3803.8802 | 2483.7592 | 3410.7981 | 3606.0726 | 3303.4108 | 3652.5461 | NA | |||
| nicotinamide | 47010.1636 | 16472.2253 | 19551.1383 | 35550.2538 | 13118.5427 | 13864.6127 | 20666.9815 | 44918.6606 | 17388.7631 | 0.847045370178886 | |||
| proline | 3046.683 | 8317.4428 | 7832.2117 | 5076.7211 | 9015.6837 | 9353.3486 | 10502.5424 | ND | 8398.948 | 0.250458467384304 | |||
| propane-1,3-diamine | 4887.3965 | 4748.5193 | 4040.3942 | 4242.982 | 4523.5219 | 4701.4085 | 5526.1802 | 4699.003 | 5142.0196 | 0.0748124591481107 | |||
| putrescine | 466547.34 | 449161.8852 | 408843.0228 | 408843.0228 | 431725.8884 | 448715.1546 | 504148.4867 | 448472.8692 | 486407.8882 | 0.00770233886126184 | |||
| pyroglutamate | 22714.3291 | 15375.221 | 14317.5035 | 24139.145 | 13056.6397 | 17173.1718 | 18498.7265 | 23351.9851 | 13514.2932 | 0.308989102996587 | |||
| pyruvate | 17972.2199 | 21425.9782 | 26818.009 | 15729.0509 | 20512.0573 | 20957.4887 | 20632.0236 | 15192.8951 | 22111.7017 | 0.00994000129801594 | |||
| ribulose | 6417.2039 | 5889.0838 | 6018.8597 | 7127.6991 | 6574.2559 | 7330.9206 | 6732.4385 | 6872.0238 | 6297.7339 | 0.00994000129801594 | |||
| similar to inositol (6TMS)317 | 1715.7205 | 1630.519 | 1706.1471 | 1874.2708 | 1759.626 | 1824.2287 | 1893.9746 | 1941.7493 | 1687.7408 | 0.00770233886126184 | |||
| spermidine | 140845.646 | 39327.0178 | 3923.3458 | 21226.5088 | 42843.3437 | 11618.2769 | 35263.3911 | 88162.1833 | 118017.6342 | 1 | |||
| succinate | 1912.0456 | 1116.8168 | 927.6257 | 1663.6095 | 1022.5537 | 907.234 | 818.2711 | 1611.1364 | 934.2252 | 0.0591670464363884 | |||
| succinic-acid-methylester | 2098.504 | 1963.1193 | 2770.9348 | 1962.0939 | 2036.8999 | 2049.5537 | 2051.8491 | 1681.4422 | 1771.7222 | NA | |||
| threonine | 1809.5777 | 5459.8408 | 5240.8193 | 1869.4605 | 7234.2057 | 7606.6757 | 6699.2267 | 1882.7881 | 5680.168 | 1 | |||
| trehalose | 3914788.5726 | 3880597.8017 | 4117361.4604 | 4040056.1706 | 3901180.9742 | 3895773.2994 | 3931307.9917 | 4039860.1311 | 3731177.2335 | 0.00770233886126184 | |||
| unidentified metabolite_1687.88 | 3338.826 | 2469.2189 | 3144.7788 | 3806.7389 | 3316.4726 | 2947.8242 | 3241.2736 | 3461.5197 | 3183.6198 | 0.00770233886126184 | |||
| Unknown_bth-pae-014_1178.4 | 4415.5251 | 4250.0523 | 5367.8798 | 4638.4656 | 4982.3932 | 5005.5958 | 4638.4656 | 4532.8552 | 4536.0472 | 0.0135307578908814 | |||
| Unknown_bth-pae-025_1411.4 | 45380.672 | 13073.8567 | 21786.2366 | 40427.7361 | 13709.9821 | 14745.4279 | 10183.8539 | 41412.8437 | 10594.4042 | 1 | |||
| Unknown_Sso_003 | 17126.9605 | 14876.8379 | 16923.5158 | 16461.5686 | 15206.3265 | 16023.6236 | 16458.2892 | 18899.827 | 16461.5686 | 0.00770233886126184 | |||
| Unknown_Sso_005 | 1008.2958 | 770.1221 | 860.7599 | 771.3053 | 682.9621 | 693.6661 | ND | 683.9545 | ND | 0.011489780604121 | |||
| Unknown_Sso_008 | 107639.8701 | 129595.4823 | 63168.3411 | 84393.2967 | 89626.9425 | 111645.1002 | 111709.8179 | 77620.2634 | 119341.5536 | 0.0894025449190997 | |||
| Unknown_Sso_010 | 29255.0893 | 26854.6049 | 45588.6603 | 29687.2166 | 23532.8504 | 22513.9666 | 33250.4241 | 27976.2537 | 24988.5745 | 0.046493455172801 | |||
| Unknown_Sso_013 | 14844.2812 | 14610.8873 | 15775.1901 | 17020.6471 | 16176.572 | 17252.7105 | 16919.0283 | 16910.5217 | 15632.939 | NA | |||
| Unknown_Sso_016 | 2673.5281 | 2757.6982 | 5103.2232 | 4938.7748 | 4943.5814 | 5936.0214 | 4200.5145 | 3960.3032 | 3411.1102 | NA | |||
| valine | 18303.9536 | 28820.7597 | 26771.7454 | 20010.9232 | 27909.3554 | 30524.5022 | 33232.7906 | 19679.5154 | 26250.9275 | 0.011489780604121 | |||
| α-D-galactopyranosid-(1,4)-D-galcatopyranose | 14826.6132 | 19610.5219 | 17163.655 | 19167.3013 | 16392.6195 | 14958.6074 | 25513.2749 | 19856.1872 | 15423.753 | NA | |||
| normalised peak area | |||||||||||||
| Cultivation 1 | Cultivation 2 | Cultivation 3 | |||||||||||
| Coenzyme A derivatives | Glc:1 | Glc:2 | Glc:3 | Glc:4 | Glc:5 | Glc:6 | Glc:7 | Glc:8 | Glc:9 | p-value_adjusted | |||
| (S)-2-Methylbutanoyl-CoA | 11813.204348448262 | 10822.7258181819 | 9968.05279470867 | 5924.100144918327 | 7696.732667069088 | 6438.161881440081 | 9769.391093097092 | 12874.012359771988 | 9887.80269838822 | 0.0217091395047538 | |||
| 3-Hydroxy-2-methylbutyryl-CoA | 459576.4760082148 | 404736.895999999 | 410919.1340667735 | 394750.0686135076 | 386726.48355544294 | 376326.84343081986 | 378705.07963325566 | 405449.27311141224 | 403808.22103191644 | 0.00770233886126184 | |||
| 3-Hydroxybutanoyl-CoA | 14624.080775324628 | 17800.5901666666 | 15590.140229062534 | 17738.569989146286 | 19991.9463898763 | 18556.448718107345 | 19349.6529253896 | 21045.747064514155 | 18191.350238774543 | 0.409589617458569 | |||
| Acetoacetyl-CoA | 3349.5556393361267 | 2979.6838235294 | 2198.5814569859317 | 1349.1806679780393 | 1188.5208569503475 | 1621.592634555659 | 2455.5116757811065 | 2108.3458376117583 | 1804.1938408118608 | 0.00770233886126184 | |||
| Acetyl-CoA | 642305.253225389 | 650649.976000003 | 621967.2731466 | 554293.7603515219 | 550417.5678180903 | 527054.2379077467 | 587591.2591407575 | 618816.4964664849 | 576567.4101620612 | 0.00844451171247201 | |||
| Benzoyl-CoA | 4411.881115569327 | 4526.16687499999 | 4541.834038884411 | 4705.165764383201 | 5948.701353476478 | 5938.313966925366 | 6594.980970774665 | 7649.5805058420765 | 6493.072253217206 | 0.0894025449190997 | |||
| Beta-methylcrotonyl-CoA | 29934.956378451443 | 29733.4707692308 | 28859.289756859947 | 29837.429269635944 | 37238.034999068135 | 34653.18904670944 | 32359.662373988074 | 38526.58265080098 | 31763.09067487731 | 0.0894025449190997 | |||
| β-Hydroxy-β-methylglutaryl CoA | 187443.91254646707 | 201117.168484849 | 209536.78008272097 | 123449.28464889496 | 116983.6475957105 | 135034.63286716928 | 133306.7255228922 | 175465.32622173824 | 164654.50634970082 | 0.012847551828305 | |||
| Butanoyl-CoA | 3422.008817771604 | 3963.80745945944 | 3744.8013786073143 | 3149.497278194892 | 5721.565879259321 | 5891.491170864064 | 4730.283968598041 | 2161.9825713326977 | 5478.991735744726 | 1 | |||
| CoenzymeA | 19985.78497236513 | 16979.31585 | 20314.2458657528 | 20928.80505995853 | 21849.951116369448 | 16979.315850000006 | 20521.751307121423 | 17152.233327308742 | 20026.62910060876 | 0.505245237778958 | |||
| Crotonoyl-CoA | 674.9544013732003 | 1306.38563265307 | 1301.8792245307461 | 1452.6686191490346 | 831.2882937011207 | 1383.9841623050029 | 1591.828830373185 | 1358.7524939486552 | 1592.7811029032057 | 0.209742706014445 | |||
| Cyclohexa-1,5-dienecarbonyl-CoA | 1327.6528093092884 | 1772.43360000001 | 1189.2831724588673 | 795.9083753996247 | 1772.4336000000244 | 1446.8300297310013 | 1772.4336000000387 | 2334.2783170412113 | 1541.44935579518 | 0.00885779322538958 | |||
| Glutaryl-CoA | 756.5079144783246 | 763.900499999997 | 923.4020341074224 | 448.1554354550109 | 629.7694787254994 | 670.2289004374475 | 1206.6804023257585 | 748.9777055129704 | 955.8171881254718 | 0.0135307578908814 | |||
| Hexanoyl-CoA | 2060.850180243074 | 2124.63322500002 | 1581.9056393006147 | 2326.3959913534027 | 6200.8527744876155 | 3589.534139857729 | 3298.1687026067943 | 3221.7316439056763 | 3318.9822500979944 | 0.00885779322538958 | |||
| Isobutanoyl-CoA | 6171.324526147085 | 7591.01753846153 | 6143.319001747121 | 8284.426804918216 | 8343.168414723596 | 8306.484432920044 | 7255.189604831031 | 7372.637359967243 | 7591.01753846154 | 0.00770233886126184 | |||
| Isovaleryl-CoA | 61267.33377354223 | 58296.3480000007 | 61609.027187354004 | 57724.442796874355 | 65870.37223691 | 61289.474179231336 | 65442.00661328419 | 69111.35242099361 | 71406.53016746027 | 0.00770233886126184 | |||
| Methylmalonyl-CoA | 21236.014773275685 | 21929.0860285715 | 23761.979741844178 | 14146.438539746277 | 11810.767208823274 | 14236.406147441796 | 12741.789236082977 | 13731.227646638878 | 15845.296896771082 | 0.159216529165329 | |||
| Pentanoyl-CoA | 5079.499668745997 | 4735.76081081082 | 3331.1591133420457 | 4197.857155273702 | 4149.176902593558 | 4285.728785706057 | 3568.596602134149 | 4710.842352843191 | 4403.733900607394 | 0.209742706014445 | |||
| Phenylacetyl-CoA | 1995.6329762895325 | 1717.63937500001 | 2446.525278189755 | 2503.177737888485 | 3313.49049368651 | 2754.257477227488 | 2702.085360965572 | 3208.103252433464 | 2470.4258108637464 | 0.0135307578908814 | |||
| Propanoyl-CoA | 55967.84777777792 | 55967.8477777781 | 56412.153045396255 | 46546.151823924534 | 45855.05920246183 | 51625.084561502634 | 49504.08377501553 | 54378.39888042382 | 50497.388570071846 | 0.00770233886126184 | |||
| Succinyl-CoA | 44558.85148262673 | 44267.7077142857 | 47204.432889678304 | 55248.61346720485 | 59121.04449266014 | 50132.01187586983 | 39870.09091117744 | 31191.10403004065 | 40488.56351220111 | 0.0171655296269177 |
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