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G Trajectories of Z from different initial concentrations of Z (i) or y (ii) for the circuit depicted in (F). The healthy concentration Z = ZST is not reached for small values of Z (Z << ZST) or large values of y (y >> yUST).
SED-ML simulation https://jjj.bio.vu.nl/models/experiments/karin2017_fig1g/simulate
Submitter: Jacky Snoep
Investigation: Karin et al (2017) Molecular Systems Biology
Assays: Biphasic control can resist mutant invasion of feedback circuits.