// Created by libAntimony v2.9.4
model *U2020_3()

  // Compartments and Species:
  compartment cell;
  species cL_m in cell, cL in cell, cLmod in cell, cP in cell, cP9_m in cell;
  species cP9 in cell, cP7_m in cell, cP7 in cell, cP5_m in cell, cP5 in cell;
  species cT_m in cell, cT in cell, cE4_m in cell, cE4 in cell, cE3_m in cell;
  species cE3c in cell, cE3n in cell, cLUX_m in cell, cLUX in cell, cCOP1c in cell;
  species cCOP1n in cell, cCOP1d in cell, cEGc in cell, cEC in cell, cZTL in cell;
  species cZG in cell, cG_m in cell, cGc in cell, cGn in cell, cEGn in cell;
  species cE34 in cell;

  // Assignment Rules:
  cGn_tot := cGn + cEGn;

  // Reactions:
  cL_m_trscr:  => cL_m; cell*(q1*L*cP*gml + (n1*gp7^2*g1^2/(gp7^2*g1^2 + (cP9 + cP7 + cP5 + cT)^2))*gml - (m1*L + m2*(1 - L))*cL_m);
  cL_m_trans:  => cL; cell*(((p2 + p1*L)*cL_m/gml)*gl - m3*cL - p3*gl*cL^2/(cL^2 + gl^2*g3^2));
  cL_mod_pro:  => cLmod; cell*(p3*gl*cL^2/(cL^2 + gl^2*g3^2) - m3*cLmod);
  cP_prod:  => cP; cell*(p7*(1 - L)*(1 - cP) - m11*cP*L);
  cE4_trscr:  => cE4_m; cell*(((n13*ge3*g2/(ge3*g2 + cEC))*gl^2*g6^2/(gl^2*g6^2 + cL^2))*gm4 - m34*cE4_m);
  cE4_trans:  => cE4; cell*((p23*ge3*cE4_m/gm4 - m35*cE4 - (p25/ge3)*cE4*cE3n) + p21*cE34);
  cE3_trscr:  => cE3_m; cell*((n3*gl^2*g16^2/(gl^2*g16^2 + cL^2))*gm3 - m26*cE3_m);
  cE3c_trans:  => cE3c; cell*((p16*ge3*cE3_m/gm3 - m9*cE3c*cCOP1c - (p17/ge3)*cE3c*cGc - p19*cE3c) + p20*cE3n);
  cE3n_trans:  => cE3n; cell*((p19*cE3c - p20*cE3n - (p17/ge3)*cE3n*cGn - m30*cE3n*cCOP1d - m29*cE3n*cCOP1n) + p21*cE34 - (p25/ge3)*cE4*cE3n);
  cLUX_trscr:  => cLUX_m; cell*(((n13*ge3*g2/(ge3*g2 + cEC))*gl^2*g6^2/(gl^2*g6^2 + cL^2))*gm4 - m34*cLUX_m);
  cLUX_trans:  => cLUX; cell*(p27*ge3*cLUX_m/gm4 - m39*cLUX - (p26/ge3)*cLUX*cE34);
  cCOP1c_prod:  => cCOP1c; cell*(n5 - p6*cCOP1c - m27*cCOP1c*(1 + p15*L));
  cCOP1n_trans:  => cCOP1n; cell*(p6*cCOP1c - n6*L*cP*cCOP1n - n14*cCOP1n - m27*cCOP1n*(1 + p15*L));
  cCOP1d_trans:  => cCOP1d; cell*(n14*cCOP1n + n6*L*cP*cCOP1n - m31*(1 + m33*(1 - L))*cCOP1d);
  cEGc_prod:  => cEGc; cell*(((p17/ge3)*cE3c*cGc - m9*cEGc*cCOP1c - p18*cEGc) + p31*cEGn);
  cEC_form:  => cEC; cell*((p26/ge3)*cLUX*cE34 - m36*cEC*cCOP1n - m37*cEC*cCOP1d - m32*cEC*(1 + p24*L*cGn_tot^2/(ge3^2*g7^2 + cGn_tot^2)));
  cZTL_prod:  => cZTL; cell*((ge3*p14 - (p12/ge3)*L*cZTL*cGc) + p13*cZG*(1 - L) - m20*cZTL);
  cZG_prod:  => cZG; cell*((p12/ge3)*L*cZTL*cGc - p13*cZG*(1 - L) - m21*cZG);
  cG_m_trscr:  => cG_m; cell*(L*q2*cP*gmg + ((n12*ge3*g14/(ge3*g14 + cEC))*gl^2*g15^2/(gl^2*g15^2 + cL^2))*gmg - m18*cG_m);
  cG_trans:  => cGc; cell*(((p11*ge3*cG_m/gmg - (p12/ge3)*L*cZTL*cGc) + p13*cZG*(1 - L) - m19*cGc - (p17/ge3)*cE3c*cGc - p28*cGc) + p29*cGn);
  cGn_traspo:  => cGn; cell*(p28*cGc - (p29 + m19 + (p17/ge3)*cE3n)*cGn);
  cE34_compl:  => cE34; cell*((p25/ge3)*cE4*cE3n - ((p26/ge3)*cLUX + p21 + m37*cCOP1d + m36*cCOP1n)*cE34);
  cEGn_tranp:  => cEGn; cell*(p18*cEGc + (p17/ge3)*cE3n*cGn - (m9*cCOP1n + m10*cCOP1d + p31)*cEGn);
  cP9mt_synt:  => cP9_m; cell*(q3t*L*cP*gm9 + ((((nt1*(gl*g1t + at1*cLmod)/(gl*g1t + cLmod))*gl^2*g2t^2/(gl^2*g2t^2 + cL^2))*ge3*g3t/(ge3*g3t + cEC))*gp7^2*g4t^2/(gp7^2*g4t^2 + (cP5 + cT)^2))*gm9 - m1t*cP9_m);
  cP9t_synt:  => cP9; cell*((p1t*cP9_m/gm9)*gp7 - mp1t*cP9);
  cP7msynt:  => cP7_m; cell*((((nt2*gl^2*g5t^2/(gl^2*g5t^2 + cL^2))*ge3*g6t/(ge3*g6t + cEC))*gp7^2*g7t^2/(gp7^2*g7t^2 + (cP5 + cT)^2))*gm7 +OX- m2t*cP7_m);
  cP7tsynt:  => cP7; cell*((p2t*cP7_m/gm7)*gp7 - (mp2t + mp3t*(1 - L))*cP7);
  cP5mtsynt:  => cP5_m; cell*(((((nt3*(gl*g8t + at2*cLmod)/(gl*g8t + cLmod))*gl^2*g9t^2/(gl^2*g9t^2 + cL^2))*ge3*g10t/(ge3*g10t + cEC))*gp7^2*g11t^2/(gp7^2*g11t^2 + cT^2))*gm5 - m3t*cP5_m);
  cP5tsynt:  => cP5; cell*((p3t*cP5_m/gm5)*gp7 - (mp4t + mp5t*(1 - L))*cP5);
  cTmtsynt:  => cT_m; cell*(((((nt4*(gl*g12t + at3*cLmod)/(gl*g12t + cLmod))*gl^2*g13t^2/(gl^2*g13t^2 + cL^2))*ge3*g14t/(ge3*g14t + cEC))*gp7^2*g15t^2/(gp7^2*g15t^2 + cT^2))*gmt - m4t*cT_m);
  cTtsynt:  => cT; cell*((p4t*cT_m/gmt)*gp7 - (mp6t + mp7t*(1 - L))*cT*(p5t*cZTL/ge3 + cZG/(dZG*ge3)) - mp8t*cT);

  // Events:
  _E0: at ((time%24) >= 12) && (time < (24*11)): L = 0;
  _E1: at ((time%24) < 12) && (time < (24*11)): L = 1;
  _E2: at time >= (24*11): L = 1;

  // Species initializations:
  cL_m = 43.0496099011453;
  cL = 16925.0525117254;
  cLmod = 5112.16859028619;
  cP = -8.95831212007076e-24;
  cP9_m = 0.00686557002727458;
  cP9 = 32.3439152406114;
  cP7_m = 3.69970078605935;
  cP7 = 3154.66076705621;
  cP5_m = 0.327201754840444;
  cP5 = 853.95420278542;
  cT_m = 17.1453822654266;
  cT = 6930.69905463137;
  cE4_m = 16.5778896688301;
  cE4 = 5925.52375918698;
  cE3_m = 23.6906243341856;
  cE3c = 2475.04869897182;
  cE3n = 547.046614713856;
  cLUX_m = 16.5778896688302;
  cLUX = 40533.2029142613;
  cCOP1c = 0.23;
  cCOP1n = 0.276;
  cCOP1d = 0.0920000000003795;
  cEGc = 351.742653940634;
  cEC = 5535.50903043581;
  cZTL = 483.695725942954;
  cZG = 49099.0666826296;
  cG_m = 5.3351960591679;
  cGc = 36.5807039526258;
  cGn = 43.4544092244416;
  cEGn = 48.7340247036102;
  cE34 = 4923.0581784464;

  // Compartment initializations:
  cell = 1;

  // Variable initializations:
  L = 1;
  q1 = 201.991035177866;
  gml = 1;
  n1 = 202.990103171986;
  gp7 = 1;
  g1 = 5397.82091939056;
  m1 = 0.670834664613965;
  m2 = 0.0340413467654981;
  p2 = 93.584354784734;
  p1 = 87.7506075914031;
  gl = 1;
  m3 = 0.18299561510966;
  p3 = 21032.9204231973;
  g3 = 67131.8939348006;
  p7 = 0.3;
  m11 = 1;
  n13 = 130.717987864745;
  ge3 = 1;
  g2 = 368.168094823538;
  g6 = 18551.7419742943;
  gm4 = 1;
  m34 = 0.520001910877006;
  p23 = 86.3249840521337;
  m35 = 0.251701024004244;
  p25 = 0.0196541138407278;
  p21 = 12.6922327745755;
  n3 = 16.1088748271814;
  g16 = 20038.137476692;
  gm3 = 1;
  m26 = 0.479114489727566;
  p16 = 447.557973564302;
  m9 = 7.65600855355685;
  p17 = 0.00648611331950286;
  p19 = 2.37343659427333;
  p20 = 0.0794133123840745;
  m30 = 3.1404732729468;
  m29 = 28.1321265096871;
  p27 = 777.13790885247;
  m39 = 0.550029312140892;
  p26 = 5.7318269341725e-06;
  n5 = 0.23;
  p6 = 0.6;
  m27 = 0.1;
  p15 = 3;
  n6 = 20;
  n14 = 0.1;
  m31 = 0.3;
  m33 = 13;
  p18 = 0.0717683045911937;
  p31 = 0.167849806458022;
  m36 = 0.154173689110563;
  m37 = 1.05942307506605;
  m32 = 0.0895010003824338;
  p24 = 20.605425719513;
  g7 = 836.055271902828;
  p14 = 3955.81882740226;
  p12 = 0.013767959497611;
  p13 = 0.0205581300721078;
  m20 = 7.67120912129754;
  m21 = 0.0242363066130928;
  q2 = 152.478483322193;
  gmg = 1;
  n12 = 1143.99321521799;
  g14 = 151.101422475578;
  g15 = 27125.1526593952;
  m18 = 4.17966750897608;
  p11 = 241.367969892948;
  m19 = 3.86135682339273;
  p28 = 8.87510536167421;
  p29 = 0.166143604608238;
  m10 = 15.6451190006989;
  q3t = 126.949241336954;
  gm9 = 1;
  nt1 = 7.13676538604487;
  g1t = 78571.2781568848;
  at1 = 0.0154025001255462;
  g2t = 3084281.19622517;
  g3t = 19.8635613803427;
  g4t = 3166.40426577328;
  m1t = 0.466643330264332;
  p1t = 1459.39718810982;
  mp1t = 0.485683294132029;
  nt2 = 1853.85280491463;
  g5t = 4266496.13277543;
  g6t = 140.534840734652;
  g7t = 1282.94294014039;
  gm7 = 1;
  m2t = 0.32656907480463;
  p2t = 782.381889558949;
  mp2t = 1.00500938018689;
  mp3t = 19.9338066250335;
  nt3 = 81.8692593216738;
  g8t = 5871.5113073441;
  at2 = 3.54004019931696;
  g9t = 64222.9796738386;
  g10t = 557.850239088585;
  g11t = 5103.04150699091;
  gm5 = 1;
  m3t = 16.2011740348675;
  p3t = 1203.02555123651;
  mp4t = 0.496268231237839;
  mp5t = 0.000635712989498298;
  nt4 = 29.912032281753;
  g12t = 760114.837266978;
  at3 = 5.53830451337711;
  g13t = 18663.8509738919;
  g14t = 294.253303911323;
  g15t = 684891.409756983;
  gmt = 1;
  m4t = 0.222188513898683;
  p4t = 239.729030600976;
  mp6t = 0.0799695902641432;
  mp7t = 0.0536272828682829;
  p5t = 0.000199650108354163;
  dZG = 10277.7344574696;
  mp8t = 0.358599276784736;
  OX=0;

  // Other declarations:
  var L, cGn_tot;
  const cell, q1, gml, n1, gp7, g1, m1, m2, p2, p1, gl, m3, p3, g3, p7, m11;
  const n13, ge3, g2, g6, gm4, m34, p23, m35, p25, p21, n3, g16, gm3, m26;
  const p16, m9, p17, p19, p20, m30, m29, p27, m39, p26, n5, p6, m27, p15;
  const n6, n14, m31, m33, p18, p31, m36, m37, m32, p24, g7, p14, p12, p13;
  const m20, m21, q2, gmg, n12, g14, g15, m18, p11, m19, p28, p29, m10, q3t;
  const gm9, nt1, g1t, at1, g2t, g3t, g4t, m1t, p1t, mp1t, nt2, g5t, g6t;
  const g7t, gm7, m2t, p2t, mp2t, mp3t, nt3, g8t, at2, g9t, g10t, g11t, gm5;
  const m3t, p3t, mp4t, mp5t, nt4, g12t, at3, g13t, g14t, g15t, gmt, m4t;
  const p4t, mp6t, mp7t, p5t, dZG, mp8t;
  const OX;

  // Unit definitions:
  unit substance = 1e-9 mole;
  unit extent = 1e-9 mole;
  unit time_unit = 3.6e3 second;
  unit area = metre^2;
  unit length = metre;
  unit volume = litre;

  // Display Names:
  substance is "nM (default)";
  time_unit is "hour (default)";
end