// Created by libAntimony v2.9.4
model *U2020_3()

  // Compartments and Species:
  compartment cell;
  species cL_m in cell, cL in cell, cLmod in cell, cP in cell, cP9_m in cell;
  species cP9 in cell, cP7_m in cell, cP7 in cell, cP5_m in cell, cP5 in cell;
  species cT_m in cell, cT in cell, cE4_m in cell, cE4 in cell, cE3_m in cell;
  species cE3c in cell, cE3n in cell, cLUX_m in cell, cLUX in cell, cCOP1c in cell;
  species cCOP1n in cell, cCOP1d in cell, cEGc in cell, cEC in cell, cZTL in cell;
  species cZG in cell, cG_m in cell, cGc in cell, cGn in cell, cEGn in cell;
  species cE34 in cell;

  // Assignment Rules:
  cGn_tot := cGn + cEGn;

  // Reactions:
  cL_m_trscr:  => cL_m; cell*(q1*L*cP*gml + (n1*gp7^2*g1^2/(gp7^2*g1^2 + (cP9 + cP7 + cP5 + cT)^2))*gml - (m1*L + m2*(1 - L))*cL_m);
  cL_m_trans:  => cL; cell*((p2 + p1*L)*cL_m/gml*gl - m3*cL - p3*gl*cL^2/(cL^2 + gl^2*g3^2));
  cL_mod_pro:  => cLmod; cell*(p3*cL^2/(cL^2 + gl^2*g3^2) - m3*cLmod);
  cP_prod:  => cP; cell*(p7*(1 - L)*(1 - cP) - m11*cP*L);
  cE4_trscr:  => cE4_m; cell*(((n13*ge3*g2/(ge3*g2 + cEC))*gl^2*g6^2/(gl^2*g6^2 + cL^2))*gm4 - m34*cE4_m);
  cE4_trans:  => cE4; cell*((p23*ge3*cE4_m/gm4 - m35*cE4 - p25/ge3*cE4*cE3n) + p21*cE34);
  cE3_trscr:  => cE3_m; cell*((n3*gl^2*g16^2/(gl^2*g16^2 + cL^2))*gm3 - m26*cE3_m);
  cE3c_trans:  => cE3c; cell*((p16*ge3*cE3_m/gm3 - m9*cE3c*cCOP1c - p17/ge3*cE3c*cGc - p19*cE3c) + p20*cE3n);
  cE3n_trans:  => cE3n; cell*((p19*cE3c - p20*cE3n - p17/ge3*cE3n*cGn - m30*cE3n*cCOP1d - m29*cE3n*cCOP1n) + p21*cE34 - p25/ge3*cE4*cE3n);
  cLUX_trscr:  => cLUX_m; cell*(((n13*ge3*g2/(ge3*g2 + cEC))*gl^2*g6^2/(gl^2*g6^2 + cL^2))*gm4 - m34*cLUX_m);
  cLUX_trans:  => cLUX; cell*(p27*ge3*cLUX_m/gm4 - m39*cLUX - p26/ge3*cLUX*cE34);
  cCOP1c_prod:  => cCOP1c; cell*(n5 - p6*cCOP1c - m27*cCOP1c*(1 + p15*L));
  cCOP1n_trans:  => cCOP1n; cell*(p6*cCOP1c - n6*L*cP*cCOP1n - n14*cCOP1n - m27*cCOP1n*(1 + p15*L));
  cCOP1d_trans:  => cCOP1d; cell*(n14*cCOP1n + n6*L*cP*cCOP1n - m31*(1 + m33*(1 - L))*cCOP1d);
  cEGc_prod:  => cEGc; cell*((p17/ge3*cE3c*cGc - m9*cEGc*cCOP1c - p18*cEGc) + p31*cEGn);
  cEC_form:  => cEC; cell*(p26/ge3*cLUX*cE34 - m36*cEC*cCOP1n - m37*cEC*cCOP1d - m32*cEC*(1 + p24*L*cGn_tot^2/(ge3^2*g7^2 + cGn_tot^2)));
  cZTL_prod:  => cZTL; cell*((ge3*p14 - p12/ge3*L*cZTL*cGc) + p13*cZG*(1 - L) - m20*cZTL);
  cZG_prod:  => cZG; cell*(p12/ge3*L*cZTL*cGc - p13*cZG*(1 - L) - m21*cZG);
  cG_m_trscr:  => cG_m; cell*(L*q2*cP*gmg + ((n12*ge3*g14/(ge3*g14 + cEC))*gl^2*g15^2/(gl^2*g15^2 + cL^2))*gmg - m18*cG_m);
  cG_trans:  => cGc; cell*(((p11*ge3*cG_m/gmg - p12/ge3*L*cZTL*cGc) + p13*cZG*(1 - L) - m19*cGc - p17/ge3*cE3c*cGc - p28*cGc) + p29*cGn);
  cGn_traspo:  => cGn; cell*(p28*cGc - (p29 + m19 + p17/ge3*cE3n)*cGn);
  cE34_compl:  => cE34; cell*(p25/ge3*cE4*cE3n - (p26/ge3*cLUX + p21 + m37*cCOP1d + m36*cCOP1n)*cE34);
  cEGn_tranp:  => cEGn; cell*(p18*cEGc + p17/ge3*cE3n*cGn - (m9*cCOP1n + m10*cCOP1d + p31)*cEGn);
  
  
  cP9mt_synt:  => cP9_m; cell*(q3t*L*cP*gm9 + ((((nt1*(g1t + at1*cLmod)/(g1t + cLmod))*gl^2*g2t^2/(gl^2*g2t^2 + cL^2))*ge3*g3t/(ge3*g3t + cEC))*gp7^2*g4t^2/(gp7^2*g4t^2 + (cP5 + cT)^2))*gm9 - m1t*cP9_m);
  cP9t_synt:  => cP9; cell*(p1t*cP9_m/gm9*gp7 - mp1t*cP9);
  cP7msynt:  => cP7_m; cell*((((nt2*gl^2*g5t^2/(gl^2*g5t^2 + cL^2))*ge3*g6t/(ge3*g6t + cEC))*gp7^2*g7t^2/(gp7^2*g7t^2 + (cP5 + cT)^2))*gm7 - m2t*cP7_m);
  cP7tsynt:  => cP7; cell*(p2t*cP7_m/gm7*gp7 - (mp2t + mp3t*(1 - L))*cP7);
  cP5mtsynt:  => cP5_m; cell*(((((nt3*(g8t + at2*cLmod)/(g8t + cLmod))*gl^2*g9t^2/(gl^2*g9t^2 + cL^2))*ge3*g10t/(ge3*g10t + cEC))*gp7^2*g11t^2/(gp7^2*g11t^2 + cT^2))*gm5 - m3t*cP5_m);
  cP5tsynt:  => cP5; cell*(p3t*cP5_m/gm5*gp7 - (mp4t + mp5t*(1 - L))*cP5);
  cTmtsynt:  => cT_m; cell*(((((nt4*(g12t + at3*cLmod)/(g12t + cLmod))*gl^2*g13t^2/(gl^2*g13t^2 + cL^2))*ge3*g14t/(ge3*g14t + cEC))*gp7^2*g15t^2/(gp7^2*g15t^2 + cT^2))*gmt - m4t*cT_m);
  cTtsynt:  => cT; cell*(p4t*cT_m/gmt*gp7 - (mp6t + mp7t*(1 - L))*cT*(p5t*cZTL/ge3 + cZG/ge3) - mp8t*cT);

  // Species initializations:
  cL_m = 39.6595712586905;
  cL = 0.159231408043891;
  cLmod = 0.0505589290237111;
  cP = 2.51327558886306e-26;
  cP9_m = 0.00691340238982438;
  cP9 = 0.00177011483737896;
  cP7_m = 3.75179806444988;
  cP7 = 0.168097243698992;
  cP5_m = 0.307417936839564;
  cP5 = 0.0451331558246782;
  cT_m = 18.1834654122416;
  cT = 0.37025473862028;
  cE4_m = 18.0950456720111;
  cE4 = 0.624114381292733;
  cE3_m = 24.2753790086823;
  cE3c = 0.245724763796227;
  cE3n = 0.0512383989698776;
  cLUX_m = 18.0950456720111;
  cLUX = 4.31435333565222;
  cCOP1c = 0.23;
  cCOP1n = 0.276;
  cCOP1d = 0.0920000000000002;
  cEGc = 0.0359441748823303;
  cEC = 0.544245606154979;
  cZTL = 0.0469964700951772;
  cZG = 4.87561660732824;
  cG_m = 5.48708692959085;
  cGc = 0.00363031881456219;
  cGn = 0.00441520376642131;
  cEGn = 0.00480196132446422;
  cE34 = 0.497553956395089;

  // Compartment initializations:
  cell = 1;

  // Variable initializations:
  q1 = 201.991035177866;
  L = 1;
  gml = 1;
  n1 = 202.990103171986;
  g1 = 0.275984353959814;
  m1 = 0.670834664613965;
  m2 = 0.0340413467654981;
  p2 = 0.000939666035113479;
  p1 = 0.000881090281638221;
  m3 = 0.18299561510966;
  p3 = 0.21118830157439;
  g3 = 0.674060966156951;
  p7 = 0.3;
  m11 = 1;
  n13 = 130.717987864745;
  g2 = 0.0358219115649522;
  g6 = 0.186275172442361;
  gm4 = 1;
  m34 = 0.520001910877006;
  p23 = 0.00839922303980085;
  m35 = 0.251701024004244;
  p25 = 201.999763051878;
  p21 = 12.6922327745755;
  n3 = 16.1088748271814;
  g16 = 0.201199839835339;
  gm3 = 1;
  m26 = 0.479114489727566;
  p16 = 0.0435463647573642;
  m9 = 7.65600855355685;
  p17 = 66.6625503589071;
  p19 = 2.37343659427333;
  p20 = 0.0794133123840745;
  m30 = 3.1404732729468;
  m29 = 28.1321265096871;
  p27 = 0.075613736866656;
  m39 = 0.550029312140892;
  p26 = 0.058910195185597;
  n5 = 0.23;
  p6 = 0.6;
  m27 = 0.1;
  p15 = 3;
  n6 = 20;
  n14 = 0.1;
  m31 = 0.3;
  m33 = 13;
  p18 = 0.0717683045911937;
  p31 = 0.167849806458022;
  m36 = 0.154173689110563;
  m37 = 1.05942307506605;
  m32 = 0.0895010003824338;
  p24 = 20.605425719513;
  g7 = 0.0813462612176367;
  p14 = 0.38489210280455;
  p12 = 141.503431737642;
  p13 = 0.0205581300721078;
  m20 = 7.67120912129754;
  m21 = 0.0242363066130928;
  q2 = 152.478483322193;
  gmg = 1;
  n12 = 1143.99321521799;
  g14 = 0.0147018219920793;
  g15 = 0.272359463394618;
  m18 = 4.17966750897608;
  p11 = 0.023484550110898;
  m19 = 3.86135682339273;
  p28 = 8.87510536167421;
  p29 = 0.166143604608238;
  m10 = 15.6451190006989;
  q3t = 126.949241336954;
  gm9 = 1;
  nt1 = 7.13676538604487;
  g1t = 0.788922054218425;
  at1 = 0.0154025001255462;
  g2t = 30.9687905579783;
  g3t = 0.00193267898314948;
  g4t = 0.161894595748038;
  m1t = 0.466643330264332;
  p1t = 0.0746172939314059;
  mp1t = 0.485683294132029;
  nt2 = 1853.85280491463;
  g5t = 42.8392279257992;
  g6t = 0.0136737178136097;
  g7t = 0.0655953918793448;
  gm7 = 1;
  m2t = 0.32656907480463;
  p2t = 0.0400022830628038;
  mp2t = 1.00500938018689;
  mp3t = 19.9338066250335;
  nt3 = 81.8692593216738;
  g8t = 0.0589549371044656;
  at2 = 3.54004019931696;
  g9t = 0.64485300787834;
  g10t = 0.0542775493370675;
  g11t = 0.260912622810023;
  gm5 = 1;
  m3t = 16.2011740348675;
  p3t = 0.0615093080176961;
  mp4t = 0.496268231237839;
  mp5t = 0.000635712989498298;
  nt4 = 29.912032281753;
  g12t = 7.63219554174991;
  at3 = 5.53830451337711;
  g13t = 0.187400841571509;
  g14t = 0.0286301718660835;
  g15t = 35.0177073447165;
  gmt = 1;
  m4t = 0.222188513898683;
  p4t = 0.0122570686623099;
  mp6t = 0.0799695902641432;
  mp7t = 0.0536272828682829;
  p5t = 2.05195079806912;
  mp8t = 0.358599276784736;
  gl=1;
  gp7=1;
  ge3=1;

  // Other declarations:
  var cGn_tot, L;
  const cell, q1, gml, n1, g1, m1, m2, p2, p1, m3, p3, g3, p7, m11, n13, g2;
  const g6, gm4, m34, p23, m35, p25, p21, n3, g16, gm3, m26, p16, m9, p17;
  const p19, p20, m30, m29, p27, m39, p26, n5, p6, m27, p15, n6, n14, m31;
  const m33, p18, p31, m36, m37, m32, p24, g7, p14, p12, p13, m20, m21, q2;
  const gmg, n12, g14, g15, m18, p11, m19, p28, p29, m10, q3t, gm9, nt1, g1t;
  const at1, g2t, g3t, g4t, m1t, p1t, mp1t, nt2, g5t, g6t, g7t, gm7, m2t;
  const p2t, mp2t, mp3t, nt3, g8t, at2, g9t, g10t, g11t, gm5, m3t, p3t, mp4t;
  const mp5t, nt4, g12t, at3, g13t, g14t, g15t, gmt, m4t, p4t, mp6t, mp7t;
  const p5t, mp8t;
  const gl,gp7,ge3;

  // Unit definitions:
  unit substance = 1e-9 mole;
  unit extent = 1e-9 mole;
  unit time_unit = 3.6e3 second;
  unit area = metre^2;
  unit length = metre;
  unit volume = litre;

  // Display Names:
  substance is "nM (default)";
  time_unit is "hour (default)";
  
      
  at (time % 24) >= 12 and time < 24*11 : L = 0;
  at (time % 24) < 12 and time < 24*11 : L = 1;
  at time >= 24*11: L= 1;
  
  
end