4.0 </head> <body/> </html> </celldesigner:notes> <celldesigner:annotation> <celldesigner:complexSpecies>s163</celldesigner:complexSpecies> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr3</celldesigner:proteinReference> <celldesigner:state> <celldesigner:listOfModifications> <celldesigner:modification residue="rs1" state="ubiquitinated"/> </celldesigner:listOfModifications> </celldesigner:state> </celldesigner:speciesIdentity> </celldesigner:annotation> </celldesigner:species> <celldesigner:species id="s169" name="p62cyt"> <celldesigner:notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body/> </html> </celldesigner:notes> <celldesigner:annotation> <celldesigner:complexSpecies>s163</celldesigner:complexSpecies> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr14</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:annotation> </celldesigner:species> <celldesigner:species id="s23" name="p62cyt"> <celldesigner:notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body/> </html> </celldesigner:notes> <celldesigner:annotation> <celldesigner:complexSpecies>s161</celldesigner:complexSpecies> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr14</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:annotation> </celldesigner:species> <celldesigner:species id="s22" name="KEAP1"> <celldesigner:notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body/> </html> </celldesigner:notes> <celldesigner:annotation> <celldesigner:complexSpecies>s161</celldesigner:complexSpecies> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr4</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:annotation> </celldesigner:species> <celldesigner:species id="s4" name="PARK2(Parkin)"> <celldesigner:notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body/> </html> </celldesigner:notes> <celldesigner:annotation> <celldesigner:complexSpecies>s6</celldesigner:complexSpecies> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr2</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:annotation> </celldesigner:species> <celldesigner:species id="s5" name="PINKļ¼‘"> <celldesigner:notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body/> </html> </celldesigner:notes> <celldesigner:annotation> <celldesigner:complexSpecies>s6</celldesigner:complexSpecies> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr1</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:annotation> </celldesigner:species> <celldesigner:species id="s14" name="NRF2"> <celldesigner:notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body/> </html> </celldesigner:notes> <celldesigner:annotation> <celldesigner:complexSpecies>s160</celldesigner:complexSpecies> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr5</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:annotation> </celldesigner:species> <celldesigner:species id="s167" name="KEAP1"> <celldesigner:notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body/> </html> </celldesigner:notes> <celldesigner:annotation> <celldesigner:complexSpecies>s160</celldesigner:complexSpecies> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr4</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:annotation> </celldesigner:species> </celldesigner:listOfIncludedSpecies> <celldesigner:listOfCompartmentAliases> <celldesigner:compartmentAlias id="ca1" compartment="c1"> <celldesigner:class>SQUARE</celldesigner:class> <celldesigner:bounds x="29.0" y="481.0" w="1263.0" h="264.0"/> <celldesigner:namePoint x="495.5" y="704.5"/> <celldesigner:doubleLine thickness="12.0" outerWidth="2.0" innerWidth="1.0"/> <celldesigner:paint color="ffcccc00" scheme="Color"/> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:compartmentAlias> </celldesigner:listOfCompartmentAliases> <celldesigner:listOfComplexSpeciesAliases> <celldesigner:complexSpeciesAlias id="csa1" species="s163"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1516.4412983062334" y="232.11234401191382" w="188.0" h="77.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:backupSize w="0.0" h="0.0"/> <celldesigner:backupView state="none"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="188.0" height="77.0"/> <celldesigner:singleLine width="2.0"/> <celldesigner:paint color="ff00cccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="2.0"/> <celldesigner:paint color="fff7f7f7" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:complexSpeciesAlias> <celldesigner:complexSpeciesAlias id="csa2" species="s161"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1589.6912983062334" y="556.3649781455954" w="139.0" h="121.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:backupSize w="0.0" h="0.0"/> <celldesigner:backupView state="none"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="139.0" height="121.0"/> <celldesigner:singleLine width="2.0"/> <celldesigner:paint color="ff00cccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="2.0"/> <celldesigner:paint color="fff7f7f7" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:complexSpeciesAlias> <celldesigner:complexSpeciesAlias id="csa3" species="s6"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1522.5" y="405.0" w="115.0" h="130.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:backupSize w="0.0" h="0.0"/> <celldesigner:backupView state="none"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="115.0" height="130.0"/> <celldesigner:singleLine width="2.0"/> <celldesigner:paint color="ff00cccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="2.0"/> <celldesigner:paint color="fff7f7f7" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:complexSpeciesAlias> <celldesigner:complexSpeciesAlias id="csa4" species="s160"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="700.1912983062334" y="798.3649781455954" w="127.0" h="117.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:backupSize w="0.0" h="0.0"/> <celldesigner:backupView state="none"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="127.0" height="117.0"/> <celldesigner:singleLine width="2.0"/> <celldesigner:paint color="ffff9999" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="2.0"/> <celldesigner:paint color="fff7f7f7" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:complexSpeciesAlias> </celldesigner:listOfComplexSpeciesAliases> <celldesigner:listOfSpeciesAliases> <celldesigner:speciesAlias id="sa1" species="s20"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1032.9412983062334" y="858.1123440119138" w="30.0" h="30.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="30.0" height="30.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa2" species="s164"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="890.9412983062334" y="852.1123440119138" w="93.0" h="41.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="93.0" height="41.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffff9999" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa3" species="s20"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="517.1912983062334" y="899.8146651659838" w="30.0" h="30.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="30.0" height="30.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa4" species="s20"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="544.1912983062334" y="809.8146651659838" w="30.0" h="30.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="30.0" height="30.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa5" species="s17"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="437.4412983062334" y="398.1149781455954" w="30.0" h="30.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="30.0" height="30.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa6" species="s139"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="255.69129830623342" y="397.8649781455954" w="139.0" h="40.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="139.0" height="40.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffccffff" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa7" species="s13" compartmentAlias="ca1"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="375.4412983062334" y="540.9899781455954" w="30.0" h="30.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="346.4412983062334" y="59.98997814559539"/> <celldesigner:boxSize width="30.0" height="30.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa8" species="s137" compartmentAlias="ca1"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="288.9412983062334" y="599.4899781455954" w="160.0" h="43.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="259.9412983062334" y="118.48997814559539"/> <celldesigner:boxSize width="160.0" height="43.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffccffff" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa9" species="s3"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="309.9412983062334" y="807.1123440119138" w="32.0" h="38.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="32.0" height="38.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa10" species="s11"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="387.9412983062334" y="806.1123440119138" w="80.0" h="40.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="40.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffff9999" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa11" species="s10"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="388.9412983062334" y="904.8623440119138" w="78.0" h="34.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="78.0" height="34.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffff9999" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa12" species="s20"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1239.1912983062334" y="414.4813318326503" w="30.0" h="30.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="30.0" height="30.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa13" species="s3"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="310.1912983062334" y="903.3659912690584" w="32.0" h="38.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="32.0" height="38.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa14" species="s35" compartmentAlias="ca1"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1238.9412983062334" y="537.7816448122619" w="30.0" h="30.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="1209.9412983062334" y="56.7816448122619"/> <celldesigner:boxSize width="30.0" height="30.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa15" species="s3"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="169.19129830623342" y="398.8649781455954" w="32.0" h="38.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="32.0" height="38.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa16" species="s138" compartmentAlias="ca1"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="171.44129830623342" y="539.4899781455954" w="158.0" h="28.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="142.44129830623342" y="58.48997814559539"/> <celldesigner:boxSize width="158.0" height="28.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffccffff" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa17" species="s44" compartmentAlias="ca1"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="57.94129830623342" y="533.4899781455954" w="32.0" h="38.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="28.94129830623342" y="52.48997814559539"/> <celldesigner:boxSize width="32.0" height="38.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa18" species="s136" compartmentAlias="ca1"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="56.44129830623342" y="600.9899781455954" w="160.0" h="43.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="27.44129830623342" y="119.98997814559539"/> <celldesigner:boxSize width="160.0" height="43.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffccffff" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa19" species="s16" compartmentAlias="ca1"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1125.6912983062334" y="614.8649781455954" w="115.0" h="40.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="1096.6912983062334" y="133.8649781455954"/> <celldesigner:boxSize width="115.0" height="40.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ff009999" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa20" species="s58" compartmentAlias="ca1"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="931.1912983062334" y="618.3649781455954" w="115.0" h="38.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="902.1912983062334" y="137.3649781455954"/> <celldesigner:boxSize width="115.0" height="38.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ff009999" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa21" species="s123" compartmentAlias="ca1"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1053.1912983062334" y="541.8649781455954" w="135.0" h="28.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="1024.1912983062334" y="60.86497814559539"/> <celldesigner:boxSize width="135.0" height="28.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ff009999" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa22" species="s44" compartmentAlias="ca1"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="935.6912983062334" y="534.867612279277" w="32.0" h="38.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="906.6912983062334" y="53.867612279276955"/> <celldesigner:boxSize width="32.0" height="38.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa23" species="s3"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="979.9412983062334" y="403.1123440119138" w="32.0" h="38.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="32.0" height="38.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa24" species="s33"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1052.9412983062334" y="406.1123440119138" w="131.0" h="36.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="131.0" height="36.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ff009999" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa25" species="s15"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="359.9412983062334" y="983.6123440119138" w="193.0" h="38.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="193.0" height="38.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffff9999" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa26" species="s20"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="603.1912983062334" y="987.8146651659833" w="30.0" h="30.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="30.0" height="30.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa27" species="s29" compartmentAlias="ca1"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="629.1912983062334" y="668.8649781455954" w="80.0" h="40.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="600.1912983062334" y="187.8649781455954"/> <celldesigner:boxSize width="80.0" height="40.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffff9999" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa28" species="s8"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1660.0" y="500.0" w="80.0" h="40.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="40.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ff009999" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa29" species="s2"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1336.9412983062334" y="481.3623440119138" w="110.0" h="41.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="110.0" height="41.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa30" species="s1"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1347.9412983062334" y="409.1123440119138" w="80.0" h="40.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="40.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa31" species="s141" compartmentAlias="ca1"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="511.6912983062334" y="600.8649781455954" w="116.0" h="40.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="482.6912983062334" y="119.86497814559539"/> <celldesigner:boxSize width="116.0" height="40.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ff33ff33" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa32" species="s59" compartmentAlias="ca1"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="702.0" y="598.5" w="156.0" h="43.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="673.0" y="117.5"/> <celldesigner:boxSize width="156.0" height="43.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ff33ff33" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa33" species="s9"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1660.0" y="400.0" w="80.0" h="40.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="40.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ff009999" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa34" species="s17"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="566.1912983062334" y="339.3659912690589" w="30.0" h="30.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="342.0" y="14.496352742855038"/> <celldesigner:boxSize width="30.0" height="30.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa35" species="s25" compartmentAlias="ca1"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="509.1912983062334" y="532.3649781455954" w="40.0" h="38.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="480.1912983062334" y="51.36497814559539"/> <celldesigner:boxSize width="40.0" height="38.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa36" species="s57" compartmentAlias="ca1"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="609.6912983062334" y="536.3649781455954" w="159.0" h="29.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="580.6912983062334" y="55.36497814559539"/> <celldesigner:boxSize width="159.0" height="29.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ff33ff33" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa37" species="s13" compartmentAlias="ca1"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="809.1912983062334" y="534.8649781455954" w="30.0" h="30.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="780.1912983062334" y="53.86497814559539"/> <celldesigner:boxSize width="30.0" height="30.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa38" species="s3"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="571.1912983062334" y="391.8649781455954" w="32.0" h="38.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="32.0" height="38.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa39" species="s56"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="672.6912983062334" y="387.8649781455954" w="139.0" h="40.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="139.0" height="40.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ff33ff33" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa40" species="s7"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1003.1912983062334" y="288.8619946975175" w="138.0" h="70.0"/> <celldesigner:font size="21"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="138.0" height="70.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffff9900" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa41" species="s43"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="576.0" y="216.0" w="68.0" h="28.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="68.0" height="28.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa42" species="s19"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1144.7632662989495" y="982.8649781455954" w="90.0" h="40.0"/> <celldesigner:font size="18"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="90.0" height="40.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffff0000" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa43" species="s12"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="970.7632662989495" y="982.8649781455954" w="90.0" h="40.0"/> <celldesigner:font size="18"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="90.0" height="40.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffff0000" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa44" species="s32"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1144.1912983062332" y="120.27420291197996" w="69.0" h="25.0"/> <celldesigner:font size="18"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="69.0" height="25.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa45" species="s30"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="304.0" y="124.5" w="52.0" h="31.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="52.0" height="31.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffffff33" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa46" species="s36"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1263.5" y="106.5" w="253.0" h="27.0"/> <celldesigner:font size="20"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="253.0" height="27.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ff009999" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa47" species="s28"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="575.0" y="127.5" w="70.0" h="25.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="70.0" height="25.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa48" species="s39"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1117.7632662989495" y="849.8649781455954" w="80.0" h="40.0"/> <celldesigner:font size="18"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="40.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa49" species="s38"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1420.7632662989495" y="854.8649781455954" w="30.0" h="30.0"/> <celldesigner:font size="18"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="30.0" height="30.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa50" species="s26"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1232.2632662989495" y="849.3649781455954" w="117.0" h="41.0"/> <celldesigner:font size="18"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="117.0" height="41.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffccccff" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa51" species="s3"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1429.9761987087877" y="163.3649781455954" w="32.0" h="38.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="32.0" height="38.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa52" species="s21"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1141.6912983062332" y="185.77420291197996" w="73.0" h="24.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="73.0" height="24.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ff666600" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa53" species="s159"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1519.4761987087877" y="165.97593878068176" w="54.0" h="30.0"/> <celldesigner:font size="20"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="54.0" height="30.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ff009999" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa54" species="s20"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1659.9761987087875" y="168.8649781455954" w="30.0" h="30.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="30.0" height="30.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa55" species="s41"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="355.0" y="177.5" w="70.0" h="25.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="70.0" height="25.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa56" species="s27"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1138.7632662989497" y="234.3649781455954" w="76.0" h="25.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="76.0" height="25.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ff666600" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa57" species="s42"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="275.0" y="207.5" w="70.0" h="25.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="70.0" height="25.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffffff33" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa58" species="s38"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1445.0" y="775.0" w="30.0" h="30.0"/> <celldesigner:font size="18"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="30.0" height="30.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa59" species="s3"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1124.0" y="771.0" w="32.0" h="38.0"/> <celldesigner:font size="18"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="32.0" height="38.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa60" species="s40"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1322.0" y="770.0" w="80.0" h="40.0"/> <celldesigner:font size="18"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="40.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffccccff" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa61" species="s20"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1683.7632662989492" y="80.86497814559539" w="30.0" h="30.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="30.0" height="30.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa62" species="s24"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="737.7632662989495" y="80.61497814559539" w="199.0" h="29.25"/> <celldesigner:font size="18"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="199.0" height="29.25"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffffff33" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa63" species="s18"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="389.90680009403036" y="78.67045846313863" w="199.71293240983812" h="26.38903936491363"/> <celldesigner:font size="18"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="199.71293240983812" height="26.38903936491363"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffffff33" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa64" species="s3"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="14.0" y="71.0" w="32.0" h="38.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="32.0" height="38.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa65" species="s37"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1095.0" y="35.0" w="30.0" h="30.0"/> <celldesigner:font size="12"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="30.0" height="30.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa66" species="s31"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="903.7692800078087" y="38.47641575851594" w="70.0" h="25.0"/> <celldesigner:font size="18"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="70.0" height="25.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffccccff" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa67" species="s165"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="722.1912983062336" y="34.77168217489998" w="70.0" h="25.0"/> <celldesigner:font size="12"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="70.0" height="25.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa68" species="s17"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="864.1377411397066" y="394.8305060621444" w="30.0" h="30.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="30.0" height="30.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa69" species="s20"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1777.1377411397063" y="600.8305060621444" w="30.0" h="30.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="30.0" height="30.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa70" species="s34" complexSpeciesAlias="csa1"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1529.9412983062334" y="235.11234401191382" w="80.0" h="40.0"/> <celldesigner:font size="12"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="13.5" y="3.0"/> <celldesigner:boxSize width="80.0" height="40.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ff009999" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa71" species="s169" complexSpeciesAlias="csa1"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1607.1377411397066" y="232.83050606214442" w="94.0" h="41.0"/> <celldesigner:font size="12"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="90.69644283347316" y="0.7181620502306032"/> <celldesigner:boxSize width="94.0" height="41.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ff009999" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa72" species="s23" complexSpeciesAlias="csa2"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1599.1912983062334" y="599.9899781455954" w="94.0" h="41.0"/> <celldesigner:font size="12"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="9.5" y="43.625"/> <celldesigner:boxSize width="94.0" height="41.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ff009999" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa73" species="s22" complexSpeciesAlias="csa2"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1599.1912983062334" y="560.7399781455954" w="92.0" h="39.0"/> <celldesigner:font size="12"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="9.5" y="4.375"/> <celldesigner:boxSize width="92.0" height="39.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffff9999" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa74" species="s4" complexSpeciesAlias="csa3"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1544.25" y="447.0" w="80.0" h="40.0"/> <celldesigner:font size="12"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="21.75" y="42.0"/> <celldesigner:boxSize width="80.0" height="40.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ff009999" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa75" species="s5" complexSpeciesAlias="csa3"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1542.25" y="407.0" w="80.0" h="40.0"/> <celldesigner:font size="12"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="19.75" y="2.0"/> <celldesigner:boxSize width="80.0" height="40.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ff009999" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa76" species="s14" complexSpeciesAlias="csa4"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="724.1912983062334" y="845.3649781455954" w="80.0" h="40.0"/> <celldesigner:font size="12"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="24.0" y="47.0"/> <celldesigner:boxSize width="80.0" height="40.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffff9999" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa77" species="s167" complexSpeciesAlias="csa4"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="723.1912983062334" y="807.3649781455954" w="80.0" h="40.0"/> <celldesigner:font size="12"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="23.0" y="9.0"/> <celldesigner:boxSize width="80.0" height="40.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffff9999" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa78" species="s170"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1617.75" y="1017.5690026512411" w="140.0" h="23.0"/> <celldesigner:font size="20"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="140.0" height="23.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffff9999" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa79" species="s171"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1615.75" y="1048.5690026512411" w="130.0" h="27.0"/> <celldesigner:font size="20"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="130.0" height="27.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ff666600" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa80" species="s172"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1615.75" y="1086.5690026512411" w="131.0" h="25.0"/> <celldesigner:font size="20"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="131.0" height="25.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffff0000" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa81" species="s173"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1617.75" y="982.5690026512411" w="143.0" h="27.0"/> <celldesigner:font size="20"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="143.0" height="27.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffccccff" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa82" species="s174"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1619.75" y="912.5690026512411" w="106.0" h="26.0"/> <celldesigner:font size="20"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="106.0" height="26.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ff009999" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa83" species="s175"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1618.9412983062334" y="947.9339807968366" w="189.0" h="27.0"/> <celldesigner:font size="20"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="189.0" height="27.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffccffff" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa85" species="s177"> <celldesigner:activity>active</celldesigner:activity> <celldesigner:bounds x="1622.0132662989495" y="839.9339807968366" w="183.0" h="26.0"/> <celldesigner:font size="20"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="183.0" height="26.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffffff33" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa86" species="s7"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1615.4412983062334" y="792.9309973487588" w="69.0" h="33.0"/> <celldesigner:font size="21"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="69.0" height="33.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffff9900" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa87" species="s31"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1701.75" y="797.5690026512412" w="70.0" h="25.0"/> <celldesigner:font size="18"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="70.0" height="25.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffccccff" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa88" species="s179"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1621.0" y="747.5" w="263.0" h="32.0"/> <celldesigner:font size="20"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="263.0" height="32.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffffffff" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa84" species="s176"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="1618.75" y="875.5690026512412" w="251.0" h="32.0"/> <celldesigner:font size="20"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="251.0" height="32.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ff33ff33" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> <celldesigner:speciesAlias id="sa89" species="s41"> <celldesigner:activity>inactive</celldesigner:activity> <celldesigner:bounds x="735.0" y="167.5" w="70.0" h="25.0"/> <celldesigner:font size="16"/> <celldesigner:view state="usual"/> <celldesigner:usualView> <celldesigner:boxSize width="70.0" height="25.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="ffcccccc" scheme="Color"/> </celldesigner:usualView> <celldesigner:briefView> <celldesigner:innerPosition x="0.0" y="0.0"/> <celldesigner:boxSize width="80.0" height="60.0"/> <celldesigner:singleLine width="1.0"/> <celldesigner:paint color="3fff0000" scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> </celldesigner:listOfSpeciesAliases> <celldesigner:listOfGroups/> <celldesigner:listOfProteins> <celldesigner:protein id="pr33" name="NRF2cytUB" type="GENERIC"/> <celldesigner:protein id="pr32" name="UncouplProtProt" type="GENERIC"/> <celldesigner:protein id="pr9" name="S" type="GENERIC"/> <celldesigner:protein id="pr27" name="NRF2cyt" type="GENERIC"/> <celldesigner:protein id="pr4" name="KEAP1" type="GENERIC"/> <celldesigner:protein id="pr14" name="p62cyt" type="GENERIC"/> <celldesigner:protein id="pr6" name="KEAP1 (ROS-modified)" type="GENERIC"/> <celldesigner:protein id="pr28" name="NRF2nuc" type="GENERIC"/> <celldesigner:protein id="pr3" name="VDAC1" type="GENERIC"> <celldesigner:listOfModificationResidues> <celldesigner:modificationResidue angle="3.141592653589793" id="rs1" side="none"/> </celldesigner:listOfModificationResidues> </celldesigner:protein> <celldesigner:protein id="pr2" name="PARK2(Parkin)" type="GENERIC"/> <celldesigner:protein id="pr1" name="PINKļ¼‘" type="GENERIC"/> <celldesigner:protein id="pr26" name="VDAC1ub" type="GENERIC"/> <celldesigner:protein id="pr29" name="Snuc" type="GENERIC"/> <celldesigner:protein id="pr30" name="AntioxidantsProt" type="GENERIC"/> <celldesigner:protein id="pr10" name="DJ-1 act" type="GENERIC"/> <celldesigner:protein id="pr8" name="DJ-1 inact" type="GENERIC"/> <celldesigner:protein id="pr11" name="synuc" type="GENERIC"/> <celldesigner:protein id="pr16" name="kf=f(ROS,VDAC1SQSTM1" type="GENERIC"/> <celldesigner:protein id="pr17" name="IKK" type="GENERIC"/> <celldesigner:protein id="pr13" name="NFkBsignal" type="GENERIC"/> <celldesigner:protein id="pr12" name="aggr" type="GENERIC"/> <celldesigner:protein id="pr25" name="AP" type="GENERIC"/> <celldesigner:protein id="pr7" name="p62im" type="GENERIC"/> <celldesigner:protein id="pr18" name="Bclxl" type="GENERIC"/> <celldesigner:protein id="pr5" name="NRF2" type="GENERIC"> <celldesigner:listOfModificationResidues> <celldesigner:modificationResidue angle="3.141592653589793" id="rs1" side="none"/> </celldesigner:listOfModificationResidues> </celldesigner:protein> <celldesigner:protein id="pr34" name="KEAP1-Nrf2" type="GENERIC"/> <celldesigner:protein id="pr35" name="Alfa-synuclein" type="GENERIC"/> <celldesigner:protein id="pr36" name="DJ-1 (Park7)" type="GENERIC"/> <celldesigner:protein id="pr37" name="NFkB signalling" type="GENERIC"/> <celldesigner:protein id="pr38" name="Mitophagy" type="GENERIC"/> <celldesigner:protein id="pr39" name="Uncoupling proteins" type="GENERIC"/> <celldesigner:protein id="pr41" name="ROS generation" type="GENERIC"/> <celldesigner:protein id="pr40" name="Antioxidant response" type="GENERIC"/> </celldesigner:listOfProteins> <celldesigner:listOfGenes> <celldesigner:gene id="gn19" name="UncouplProtInactGene" type="GENE"/> <celldesigner:gene id="gn18" name="UncouplProtActGene" type="GENE"/> <celldesigner:gene id="gn16" name="p62inactGene" type="GENE"/> <celldesigner:gene id="gn17" name="p62actGene" type="GENE"/> <celldesigner:gene id="gn15" name="AntioxActGene" type="GENE"/> <celldesigner:gene id="gn14" name="AntioxidantsInactGene" type="GENE"/> <celldesigner:gene id="gn13" name="RE" type="GENE"/> <celldesigner:gene id="gn2" name="Impaired Mitochondria" type="GENE"/> <celldesigner:gene id="gn1" name="Healthy Mitochondria" type="GENE"/> <celldesigner:gene id="gn20" name="Modules notation" type="GENE"/> </celldesigner:listOfGenes> <celldesigner:listOfRNAs> <celldesigner:RNA id="rn4" name="UncouplProtRNA" type="RNA"/> <celldesigner:RNA id="rn3" name="p62mRNA" type="RNA"/> <celldesigner:RNA id="rn1" name="AntioxidantsRNA" type="RNA"/> </celldesigner:listOfRNAs> <celldesigner:listOfAntisenseRNAs/> <celldesigner:listOfLayers/> <celldesigner:listOfBlockDiagrams/> </celldesigner:extension> </annotation> <listOfUnitDefinitions> <unitDefinition metaid="substance" id="substance" name="substance"> <listOfUnits> <unit metaid="CDMT00157" kind="mole"/> </listOfUnits> </unitDefinition> <unitDefinition metaid="volume" id="volume" name="volume"> <listOfUnits> <unit metaid="CDMT00158" kind="litre"/> </listOfUnits> </unitDefinition> <unitDefinition metaid="area" id="area" name="area"> <listOfUnits> <unit metaid="CDMT00159" kind="metre" exponent="2"/> </listOfUnits> </unitDefinition> <unitDefinition metaid="length" id="length" name="length"> <listOfUnits> <unit metaid="CDMT00160" kind="metre"/> </listOfUnits> </unitDefinition> <unitDefinition metaid="time" id="time" name="time"> <listOfUnits> <unit metaid="CDMT00161" kind="second"/> </listOfUnits> </unitDefinition> </listOfUnitDefinitions> <listOfCompartments> <compartment metaid="default" id="default" size="1" units="volume"/> <compartment metaid="c1" id="c1" name="nucleus" size="1" units="volume" outside="default"> <annotation> <celldesigner:extension> <celldesigner:name>nucleus</celldesigner:name> </celldesigner:extension> </annotation> </compartment> </listOfCompartments> <listOfSpecies> <species metaid="s20" id="s20" name="s20" compartment="default" initialAmount="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>DEGRADED</celldesigner:class> <celldesigner:name>s20</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s164" id="s164" name="NRF2cytUB" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr33</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s17" id="s17" name="s5" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>DEGRADED</celldesigner:class> <celldesigner:name>s5</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s139" id="s139" name="UncouplProtProt" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr32</celldesigner:proteinReference> </celldesigner:speciesIdentity> <celldesigner:listOfCatalyzedReactions> <celldesigner:catalyzed reaction="re8"/> <celldesigner:catalyzed reaction="re41"/> <celldesigner:catalyzed reaction="re51"/> </celldesigner:listOfCatalyzedReactions> </celldesigner:extension> </annotation> </species> <species metaid="s137" id="s137" name="UncouplProtInactGene" compartment="c1" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>GENE</celldesigner:class> <celldesigner:geneReference>gn19</celldesigner:geneReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s3" id="s3" name="S" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr9</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s11" id="s11" name="NRF2cyt" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr27</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s10" id="s10" name="KEAP1" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr4</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s138" id="s138" name="UncouplProtRNA" compartment="c1" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>RNA</celldesigner:class> <celldesigner:rnaReference>rn4</celldesigner:rnaReference> </celldesigner:speciesIdentity> <celldesigner:listOfCatalyzedReactions> <celldesigner:catalyzed reaction="re24"/> </celldesigner:listOfCatalyzedReactions> </celldesigner:extension> </annotation> </species> <species metaid="s136" id="s136" name="UncouplProtActGene" compartment="c1" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>GENE</celldesigner:class> <celldesigner:geneReference>gn18</celldesigner:geneReference> </celldesigner:speciesIdentity> <celldesigner:listOfCatalyzedReactions> <celldesigner:catalyzed reaction="re22"/> </celldesigner:listOfCatalyzedReactions> </celldesigner:extension> </annotation> </species> <species metaid="s16" id="s16" name="p62inactGene" compartment="c1" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>GENE</celldesigner:class> <celldesigner:geneReference>gn16</celldesigner:geneReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s58" id="s58" name="p62actGene" compartment="c1" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>GENE</celldesigner:class> <celldesigner:geneReference>gn17</celldesigner:geneReference> </celldesigner:speciesIdentity> <celldesigner:listOfCatalyzedReactions> <celldesigner:catalyzed reaction="re19"/> </celldesigner:listOfCatalyzedReactions> </celldesigner:extension> </annotation> </species> <species metaid="s123" id="s123" name="p62mRNA" compartment="c1" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>RNA</celldesigner:class> <celldesigner:rnaReference>rn3</celldesigner:rnaReference> </celldesigner:speciesIdentity> <celldesigner:listOfCatalyzedReactions> <celldesigner:catalyzed reaction="re7"/> </celldesigner:listOfCatalyzedReactions> </celldesigner:extension> </annotation> </species> <species metaid="s33" id="s33" name="p62cyt" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr14</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s15" id="s15" name="KEAP1 (ROS-modified)" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr6</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s29" id="s29" name="NRF2nuc" compartment="c1" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr28</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s8" id="s8" name="VDAC1" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr3</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s2" id="s2" name="PARK2(Parkin)" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr2</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s1" id="s1" name="PINKļ¼‘" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr1</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s141" id="s141" name="AntioxActGene" compartment="c1" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>GENE</celldesigner:class> <celldesigner:geneReference>gn15</celldesigner:geneReference> </celldesigner:speciesIdentity> <celldesigner:listOfCatalyzedReactions> <celldesigner:catalyzed reaction="re10"/> </celldesigner:listOfCatalyzedReactions> </celldesigner:extension> </annotation> </species> <species metaid="s59" id="s59" name="AntioxidantsInactGene" compartment="c1" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>GENE</celldesigner:class> <celldesigner:geneReference>gn14</celldesigner:geneReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s9" id="s9" name="VDAC1ub" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr26</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s25" id="s25" name="Snuc" compartment="c1" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr29</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s57" id="s57" name="AntioxidantsRNA" compartment="c1" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>RNA</celldesigner:class> <celldesigner:rnaReference>rn1</celldesigner:rnaReference> </celldesigner:speciesIdentity> <celldesigner:listOfCatalyzedReactions> <celldesigner:catalyzed reaction="re12"/> </celldesigner:listOfCatalyzedReactions> </celldesigner:extension> </annotation> </species> <species metaid="s56" id="s56" name="AntioxidantsProt" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr30</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s7" id="s7" name="ROS" compartment="default" initialAmount="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>SIMPLE_MOLECULE</celldesigner:class> <celldesigner:name>ROS</celldesigner:name> </celldesigner:speciesIdentity> <celldesigner:listOfCatalyzedReactions> <celldesigner:catalyzed reaction="re3"/> <celldesigner:catalyzed reaction="re26"/> <celldesigner:catalyzed reaction="re28"/> <celldesigner:catalyzed reaction="re34"/> <celldesigner:catalyzed reaction="re36"/> <celldesigner:catalyzed reaction="re39"/> <celldesigner:catalyzed reaction="re46"/> </celldesigner:listOfCatalyzedReactions> </celldesigner:extension> </annotation> </species> <species metaid="s43" id="s43" name="RE" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>GENE</celldesigner:class> <celldesigner:geneReference>gn13</celldesigner:geneReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s19" id="s19" name="DJ-1 act" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr10</celldesigner:proteinReference> </celldesigner:speciesIdentity> <celldesigner:listOfCatalyzedReactions> <celldesigner:catalyzed reaction="re2"/> <celldesigner:catalyzed reaction="re21"/> <celldesigner:catalyzed reaction="re26"/> <celldesigner:catalyzed reaction="re43"/> </celldesigner:listOfCatalyzedReactions> </celldesigner:extension> </annotation> </species> <species metaid="s12" id="s12" name="DJ-1 inact" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr8</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s32" id="s32" name="synuc" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr11</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s30" id="s30" name="ADP" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>SIMPLE_MOLECULE</celldesigner:class> <celldesigner:name>ADP</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s36" id="s36" name="kf=f(ROS,VDAC1SQSTM1" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr16</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s28" id="s28" name="O2" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>SIMPLE_MOLECULE</celldesigner:class> <celldesigner:name>O2</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s39" id="s39" name="IKK" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr17</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s38" id="s38" name="s8" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>DEGRADED</celldesigner:class> <celldesigner:name>s8</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s26" id="s26" name="NFkBsignal" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr13</celldesigner:proteinReference> </celldesigner:speciesIdentity> <celldesigner:listOfCatalyzedReactions> <celldesigner:catalyzed reaction="re18"/> <celldesigner:catalyzed reaction="re44"/> </celldesigner:listOfCatalyzedReactions> </celldesigner:extension> </annotation> </species> <species metaid="s21" id="s21" name="aggr" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr12</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s159" id="s159" name="AP" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr25</celldesigner:proteinReference> </celldesigner:speciesIdentity> <celldesigner:listOfCatalyzedReactions> <celldesigner:catalyzed reaction="re35"/> </celldesigner:listOfCatalyzedReactions> </celldesigner:extension> </annotation> </species> <species metaid="s41" id="s41" name="H2O" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>SIMPLE_MOLECULE</celldesigner:class> <celldesigner:name>H2O</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s27" id="s27" name="p62im" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr7</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s42" id="s42" name="ATP" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>SIMPLE_MOLECULE</celldesigner:class> <celldesigner:name>ATP</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s40" id="s40" name="Bclxl" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr18</celldesigner:proteinReference> </celldesigner:speciesIdentity> <celldesigner:listOfCatalyzedReactions> <celldesigner:catalyzed reaction="re49"/> <celldesigner:catalyzed reaction="re50"/> </celldesigner:listOfCatalyzedReactions> </celldesigner:extension> </annotation> </species> <species metaid="s24" id="s24" name="Impaired Mitochondria" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>GENE</celldesigner:class> <celldesigner:geneReference>gn2</celldesigner:geneReference> </celldesigner:speciesIdentity> <celldesigner:listOfCatalyzedReactions> <celldesigner:catalyzed reaction="re41"/> <celldesigner:catalyzed reaction="re49"/> </celldesigner:listOfCatalyzedReactions> </celldesigner:extension> </annotation> </species> <species metaid="s18" id="s18" name="Healthy Mitochondria" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>GENE</celldesigner:class> <celldesigner:geneReference>gn1</celldesigner:geneReference> </celldesigner:speciesIdentity> <celldesigner:listOfCatalyzedReactions> <celldesigner:catalyzed reaction="re8"/> </celldesigner:listOfCatalyzedReactions> </celldesigner:extension> </annotation> </species> <species metaid="s37" id="s37" name="s21" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>DEGRADED</celldesigner:class> <celldesigner:name>s21</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s31" id="s31" name="CytC" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>SIMPLE_MOLECULE</celldesigner:class> <celldesigner:name>CytC</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s165" id="s165" name="S" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>SIMPLE_MOLECULE</celldesigner:class> <celldesigner:name>S</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s163" id="s163" name="VDAC1ub:p62" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>COMPLEX</celldesigner:class> <celldesigner:name>VDAC1ub:p62</celldesigner:name> </celldesigner:speciesIdentity> <celldesigner:listOfCatalyzedReactions> <celldesigner:catalyzed reaction="re39"/> </celldesigner:listOfCatalyzedReactions> </celldesigner:extension> </annotation> </species> <species metaid="s161" id="s161" name="KEAP1:p62" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>COMPLEX</celldesigner:class> <celldesigner:name>KEAP1:p62</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s6" id="s6" name="PINK1:PRK2" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>COMPLEX</celldesigner:class> <celldesigner:name>PINK1:PRK2</celldesigner:name> </celldesigner:speciesIdentity> <celldesigner:listOfCatalyzedReactions> <celldesigner:catalyzed reaction="re1"/> </celldesigner:listOfCatalyzedReactions> </celldesigner:extension> </annotation> </species> <species metaid="s160" id="s160" name="KEAP1:NRF2cyt" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>COMPLEX</celldesigner:class> <celldesigner:name>KEAP1:NRF2cyt</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s13" id="s13" name="s5" compartment="c1" initialAmount="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>DEGRADED</celldesigner:class> <celldesigner:name>s5</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s35" id="s35" name="s20" compartment="c1" initialAmount="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>DEGRADED</celldesigner:class> <celldesigner:name>s20</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s44" id="s44" name="S" compartment="c1" initialAmount="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr9</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s170" id="s170" name="KEAP1-Nrf2" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr34</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s171" id="s171" name="Alfa-synuclein" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr35</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s172" id="s172" name="DJ-1 (Park7)" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr36</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s173" id="s173" name="NFkB signalling" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr37</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s174" id="s174" name="Mitophagy" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr38</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s175" id="s175" name="Uncoupling proteins" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr39</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s177" id="s177" name="ROS generation" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr41</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s179" id="s179" name="Modules notation" compartment="default" initialAmount="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>GENE</celldesigner:class> <celldesigner:geneReference>gn20</celldesigner:geneReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s176" id="s176" name="Antioxidant response" compartment="default" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr40</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> </listOfSpecies> <listOfReactions> <reaction metaid="re2" id="re1" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s8" alias="sa28"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s9" alias="sa33"/> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="2.0" color="ff33cc00"/> <celldesigner:listOfModification> <celldesigner:modification type="MODULATION" modifiers="s6" aliases="csa3" targetLineIndex="-1,3"> <celldesigner:connectScheme connectPolicy="direct"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s6" alias="csa3"> <celldesigner:linkAnchor position="E"/> </celldesigner:linkTarget> <celldesigner:line width="3.0" color="ffff3333"/> </celldesigner:modification> </celldesigner:listOfModification> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00001" species="s8"> <annotation> <celldesigner:extension> <celldesigner:alias>sa28</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00002" species="s9"> <annotation> <celldesigner:extension> <celldesigner:alias>sa33</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid="CDMT00003" species="s6"> <annotation> <celldesigner:extension> <celldesigner:alias>csa3</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> </listOfModifiers> </reaction> <reaction metaid="re3" id="re2" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s10" alias="sa11"/> <celldesigner:baseReactant species="s11" alias="sa10"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s160" alias="csa4"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection arm="0" index="0" value="vertical"/> <celldesigner:lineDirection arm="0" index="1" value="horizontal"/> <celldesigner:lineDirection arm="0" index="2" value="vertical"/> <celldesigner:lineDirection arm="1" index="0" value="vertical"/> <celldesigner:lineDirection arm="1" index="1" value="horizontal"/> <celldesigner:lineDirection arm="1" index="2" value="vertical"/> <celldesigner:lineDirection arm="2" index="0" value="horizontal"/> <celldesigner:lineDirection arm="2" index="1" value="vertical"/> <celldesigner:lineDirection arm="2" index="2" value="horizontal"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:editPoints num0="2" num1="2" num2="2" tShapeIndex="0">0.35465630374854307,1.5925779628656045E-4 0.35465650539284077,-2.897903737046903E-4 0.4999999999999716,0.0 0.4999999999999716,0.0 0.5000000000000002,0.0 0.5000000000000002,7.549516567451064E-15 0.6826354465996438,0.0</celldesigner:editPoints> <celldesigner:line width="2.0" color="ff339900"/> <celldesigner:listOfModification> <celldesigner:modification type="INHIBITION" modifiers="s19" aliases="sa42" targetLineIndex="2,6" editPoints="-0.0102457456178493,-0.05058404625074653 0.695610954825006,-0.2120793092059765 0.7441115977712758,0.01792402440333496 0.9910296834357755,-0.04192568640767225"> <celldesigner:connectScheme connectPolicy="direct"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> <celldesigner:lineDirection index="1" value="unknown"/> <celldesigner:lineDirection index="2" value="unknown"/> <celldesigner:lineDirection index="3" value="unknown"/> <celldesigner:lineDirection index="4" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s19" alias="sa42"> <celldesigner:linkAnchor position="S"/> </celldesigner:linkTarget> <celldesigner:line width="3.0" color="ff0066ff"/> </celldesigner:modification> </celldesigner:listOfModification> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00004" species="s10"> <annotation> <celldesigner:extension> <celldesigner:alias>sa11</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> <speciesReference metaid="CDMT00005" species="s11"> <annotation> <celldesigner:extension> <celldesigner:alias>sa10</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00006" species="s160"> <annotation> <celldesigner:extension> <celldesigner:alias>csa4</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid="CDMT00007" species="s19"> <annotation> <celldesigner:extension> <celldesigner:alias>sa42</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> </listOfModifiers> </reaction> <reaction metaid="re4" id="re3" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s10" alias="sa11"> <celldesigner:linkAnchor position="SSW"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s15" alias="sa25"> <celldesigner:linkAnchor position="NNW"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> <celldesigner:listOfModification> <celldesigner:modification type="MODULATION" modifiers="s7" aliases="sa40" targetLineIndex="-1,3" editPoints="0.7785157802860329,0.8271336050542 1.3087672733450135,0.3280495969276097"> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="horizontal"/> <celldesigner:lineDirection index="1" value="vertical"/> <celldesigner:lineDirection index="2" value="horizontal"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s7" alias="sa40"> <celldesigner:linkAnchor position="W"/> </celldesigner:linkTarget> <celldesigner:line width="3.0" color="ffff3366"/> </celldesigner:modification> </celldesigner:listOfModification> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00008" species="s10"> <annotation> <celldesigner:extension> <celldesigner:alias>sa11</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00009" species="s15"> <annotation> <celldesigner:extension> <celldesigner:alias>sa25</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid="CDMT00010" species="s7"> <annotation> <celldesigner:extension> <celldesigner:alias>sa40</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> </listOfModifiers> </reaction> <reaction metaid="re11" id="re4"> <annotation> <celldesigner:extension> <celldesigner:reactionType>DISSOCIATION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s160" alias="csa4"> <celldesigner:linkAnchor position="ENE"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s10" alias="sa11"> <celldesigner:linkAnchor position="SSE"/> </celldesigner:baseProduct> <celldesigner:baseProduct species="s164" alias="sa2"/> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection arm="0" index="0" value="horizontal"/> <celldesigner:lineDirection arm="1" index="0" value="vertical"/> <celldesigner:lineDirection arm="1" index="1" value="vertical"/> <celldesigner:lineDirection arm="1" index="2" value="unknown"/> <celldesigner:lineDirection arm="2" index="0" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:editPoints num0="0" num1="2" num2="0" tShapeIndex="0">0.03542570847138515,-0.21223768233925666 0.8843764378284114,-0.07053484845370939 0.04617490738444374,0.6435218811400993</celldesigner:editPoints> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00011" species="s160"> <annotation> <celldesigner:extension> <celldesigner:alias>csa4</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00012" species="s10"> <annotation> <celldesigner:extension> <celldesigner:alias>sa11</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> <speciesReference metaid="CDMT00013" species="s164"> <annotation> <celldesigner:extension> <celldesigner:alias>sa2</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> <reaction metaid="re12" id="re5" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s164" alias="sa2"/> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s20" alias="sa1"/> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00014" species="s164"> <annotation> <celldesigner:extension> <celldesigner:alias>sa2</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00015" species="s20"> <annotation> <celldesigner:extension> <celldesigner:alias>sa1</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> <reaction metaid="re13" id="re6"> <annotation> <celldesigner:extension> <celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s10" alias="sa11"> <celldesigner:linkAnchor position="ESE"/> </celldesigner:baseReactant> <celldesigner:baseReactant species="s33" alias="sa24"> <celldesigner:linkAnchor position="SSE"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s161" alias="csa2"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection arm="0" index="0" value="unknown"/> <celldesigner:lineDirection arm="0" index="1" value="unknown"/> <celldesigner:lineDirection arm="0" index="2" value="unknown"/> <celldesigner:lineDirection arm="0" index="3" value="unknown"/> <celldesigner:lineDirection arm="1" index="0" value="unknown"/> <celldesigner:lineDirection arm="1" index="1" value="unknown"/> <celldesigner:lineDirection arm="1" index="2" value="unknown"/> <celldesigner:lineDirection arm="2" index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:editPoints num0="3" num1="2" num2="0" tShapeIndex="0">0.06302822547312648,-0.1513846890438355 0.2752229260612936,-0.0716169010086527 0.34176536996928286,-0.2474421854088249 0.45451056748704577,0.4341761735190719 0.9293391686525707,-0.06841739406887326 0.27728017830010776,0.5651070350325091</celldesigner:editPoints> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00016" species="s10"> <annotation> <celldesigner:extension> <celldesigner:alias>sa11</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> <speciesReference metaid="CDMT00017" species="s33"> <annotation> <celldesigner:extension> <celldesigner:alias>sa24</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00018" species="s161"> <annotation> <celldesigner:extension> <celldesigner:alias>csa2</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> <reaction metaid="CDMT00065" id="re7" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s3" alias="sa23"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s33" alias="sa24"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="square" rectangleIndex="2"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="horizontal"/> <celldesigner:lineDirection index="1" value="vertical"/> <celldesigner:lineDirection index="2" value="horizontal"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:editPoints>0.5863662184488838,-0.028603230168238625 0.588740105689201,0.02006145825906458</celldesigner:editPoints> <celldesigner:line width="1.0" color="ff000000"/> <celldesigner:listOfModification> <celldesigner:modification type="CATALYSIS" modifiers="s123" aliases="sa21" targetLineIndex="-1,6" editPoints="0.5395104933158841,0.32921820166600213 0.8108409300494213,-0.11542798445901781"> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="vertical"/> <celldesigner:lineDirection index="1" value="horizontal"/> <celldesigner:lineDirection index="2" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s123" alias="sa21"> <celldesigner:linkAnchor position="NNW"/> </celldesigner:linkTarget> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:modification> </celldesigner:listOfModification> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00019" species="s3"> <annotation> <celldesigner:extension> <celldesigner:alias>sa23</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00020" species="s33"> <annotation> <celldesigner:extension> <celldesigner:alias>sa24</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid="CDMT00021" species="s123"> <annotation> <celldesigner:extension> <celldesigner:alias>sa21</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> </listOfModifiers> </reaction> <reaction metaid="re29" id="re8" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s28" alias="sa47"> <celldesigner:linkAnchor position="WSW"/> </celldesigner:baseReactant> <celldesigner:baseReactant species="s43" alias="sa41"> <celldesigner:linkAnchor position="WNW"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s41" alias="sa55"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:listOfReactantLinks> <celldesigner:reactantLink reactant="s30" alias="sa45" targetLineIndex="-1,0"> <celldesigner:linkAnchor position="E"/> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="horizontal"/> <celldesigner:lineDirection index="1" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:editPoints>0.8907226239683532,-0.31198690857035105</celldesigner:editPoints> <celldesigner:line width="1.0" color="ff000000" type="Straight"/> </celldesigner:reactantLink> </celldesigner:listOfReactantLinks> <celldesigner:listOfProductLinks> <celldesigner:productLink product="s42" alias="sa57" targetLineIndex="-1,1"> <celldesigner:linkAnchor position="ESE"/> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="vertical"/> <celldesigner:lineDirection index="1" value="horizontal"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:editPoints>0.06986700641096544,-0.25492274874191834</celldesigner:editPoints> <celldesigner:line width="1.0" color="ff000000" type="Straight"/> </celldesigner:productLink> </celldesigner:listOfProductLinks> <celldesigner:connectScheme connectPolicy="direct"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection arm="0" index="0" value="vertical"/> <celldesigner:lineDirection arm="0" index="1" value="horizontal"/> <celldesigner:lineDirection arm="1" index="0" value="vertical"/> <celldesigner:lineDirection arm="1" index="1" value="horizontal"/> <celldesigner:lineDirection arm="2" index="0" value="horizontal"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:editPoints num0="1" num1="1" num2="0" tShapeIndex="0">0.6298343823671275,-0.4828488719623856 0.49999999999999645,0.5000000000000009 0.3863636363636367,0.3045454545454547</celldesigner:editPoints> <celldesigner:line width="1.0" color="ff000000"/> <celldesigner:listOfModification> <celldesigner:modification type="CATALYSIS" modifiers="s18" aliases="sa63" targetLineIndex="2,6"> <celldesigner:connectScheme connectPolicy="direct"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s18" alias="sa63"> <celldesigner:linkAnchor position="S"/> </celldesigner:linkTarget> <celldesigner:line width="3.0" color="ffff3333"/> </celldesigner:modification> <celldesigner:modification type="INHIBITION" modifiers="s139" aliases="sa6" targetLineIndex="2,4" editPoints="0.4383936972510677,-0.3540316681942839 0.8331262464080381,0.13476150257737363"> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="vertical"/> <celldesigner:lineDirection index="1" value="horizontal"/> <celldesigner:lineDirection index="2" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s139" alias="sa6"> <celldesigner:linkAnchor position="N"/> </celldesigner:linkTarget> <celldesigner:line width="2.0" color="ff3366ff"/> </celldesigner:modification> </celldesigner:listOfModification> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00022" species="s28"> <annotation> <celldesigner:extension> <celldesigner:alias>sa47</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> <speciesReference metaid="CDMT00023" species="s43"> <annotation> <celldesigner:extension> <celldesigner:alias>sa41</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> <speciesReference metaid="CDMT00024" species="s30"> <annotation> <celldesigner:extension> <celldesigner:alias>sa45</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00025" species="s41"> <annotation> <celldesigner:extension> <celldesigner:alias>sa55</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> <speciesReference metaid="CDMT00026" species="s42"> <annotation> <celldesigner:extension> <celldesigner:alias>sa57</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid="CDMT00027" species="s18"> <annotation> <celldesigner:extension> <celldesigner:alias>sa63</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> <modifierSpeciesReference metaid="CDMT00028" species="s139"> <annotation> <celldesigner:extension> <celldesigner:alias>sa6</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> </listOfModifiers> </reaction> <reaction metaid="re34" id="re9" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s59" alias="sa32"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s141" alias="sa31"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:listOfReactantLinks> <celldesigner:reactantLink reactant="s29" alias="sa27" targetLineIndex="-1,0"> <celldesigner:linkAnchor position="NNW"/> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="vertical"/> <celldesigner:lineDirection index="1" value="horizontal"/> <celldesigner:lineDirection index="2" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:editPoints>0.2200212211346928,-0.11305947017845952 0.42891273358873594,0.29345725577350734</celldesigner:editPoints> <celldesigner:line width="1.0" color="ff000000" type="Straight"/> </celldesigner:reactantLink> </celldesigner:listOfReactantLinks> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="2.0" color="ff339900"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00029" species="s59"> <annotation> <celldesigner:extension> <celldesigner:alias>sa32</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> <speciesReference metaid="CDMT00030" species="s29"> <annotation> <celldesigner:extension> <celldesigner:alias>sa27</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00031" species="s141"> <annotation> <celldesigner:extension> <celldesigner:alias>sa31</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> <reaction metaid="re36" id="re10" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s25" alias="sa35"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s57" alias="sa36"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> <celldesigner:listOfModification> <celldesigner:modification type="CATALYSIS" modifiers="s141" aliases="sa31" targetLineIndex="-1,3"> <celldesigner:connectScheme connectPolicy="direct"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s141" alias="sa31"> <celldesigner:linkAnchor position="N"/> </celldesigner:linkTarget> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:modification> </celldesigner:listOfModification> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00032" species="s25"> <annotation> <celldesigner:extension> <celldesigner:alias>sa35</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00033" species="s57"> <annotation> <celldesigner:extension> <celldesigner:alias>sa36</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid="CDMT00034" species="s141"> <annotation> <celldesigner:extension> <celldesigner:alias>sa31</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> </listOfModifiers> </reaction> <reaction metaid="re37" id="re11" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s57" alias="sa36"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s13" alias="sa37"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00035" species="s57"> <annotation> <celldesigner:extension> <celldesigner:alias>sa36</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00036" species="s13"> <annotation> <celldesigner:extension> <celldesigner:alias>sa37</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> <reaction metaid="re38" id="re12" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s3" alias="sa38"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s56" alias="sa39"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> <celldesigner:listOfModification> <celldesigner:modification type="CATALYSIS" modifiers="s57" aliases="sa36" targetLineIndex="-1,3" editPoints="0.69594097939921,0.18505820905422254 0.761979999695467,-0.0632920840693516"> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="vertical"/> <celldesigner:lineDirection index="1" value="horizontal"/> <celldesigner:lineDirection index="2" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s57" alias="sa36"> <celldesigner:linkAnchor position="NNW"/> </celldesigner:linkTarget> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:modification> </celldesigner:listOfModification> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00037" species="s3"> <annotation> <celldesigner:extension> <celldesigner:alias>sa38</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00038" species="s56"> <annotation> <celldesigner:extension> <celldesigner:alias>sa39</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid="CDMT00039" species="s57"> <annotation> <celldesigner:extension> <celldesigner:alias>sa36</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> </listOfModifiers> </reaction> <reaction metaid="re39" id="re13" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s56" alias="sa39"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s17" alias="sa68"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00040" species="s56"> <annotation> <celldesigner:extension> <celldesigner:alias>sa39</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00041" species="s17"> <annotation> <celldesigner:extension> <celldesigner:alias>sa68</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> <reaction metaid="re40" id="re14" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s3" alias="sa64"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s18" alias="sa63"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:listOfReactantLinks> <celldesigner:reactantLink reactant="s42" alias="sa57" targetLineIndex="-1,0"> <celldesigner:linkAnchor position="W"/> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="horizontal"/> <celldesigner:lineDirection index="1" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:editPoints>0.3744340400290549,-0.48397643506329435</celldesigner:editPoints> <celldesigner:line width="1.0" color="ff000000" type="Straight"/> </celldesigner:reactantLink> </celldesigner:listOfReactantLinks> <celldesigner:listOfProductLinks> <celldesigner:productLink product="s30" alias="sa45" targetLineIndex="-1,1"> <celldesigner:linkAnchor position="W"/> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="vertical"/> <celldesigner:lineDirection index="1" value="horizontal"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:editPoints>0.5626100930621618,0.4960644879919818</celldesigner:editPoints> <celldesigner:line width="1.0" color="ff000000" type="Straight"/> </celldesigner:productLink> </celldesigner:listOfProductLinks> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00042" species="s3"> <annotation> <celldesigner:extension> <celldesigner:alias>sa64</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> <speciesReference metaid="CDMT00043" species="s42"> <annotation> <celldesigner:extension> <celldesigner:alias>sa57</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00044" species="s18"> <annotation> <celldesigner:extension> <celldesigner:alias>sa63</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> <speciesReference metaid="CDMT00045" species="s30"> <annotation> <celldesigner:extension> <celldesigner:alias>sa45</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> <reaction metaid="re48" id="re15" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s3" alias="sa9"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s11" alias="sa10"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00046" species="s3"> <annotation> <celldesigner:extension> <celldesigner:alias>sa9</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00047" species="s11"> <annotation> <celldesigner:extension> <celldesigner:alias>sa10</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> <reaction metaid="re52" id="re16" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s33" alias="sa24"> <celldesigner:linkAnchor position="NNE"/> </celldesigner:baseReactant> <celldesigner:baseReactant species="s9" alias="sa33"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s163" alias="csa1"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection arm="0" index="0" value="horizontal"/> <celldesigner:lineDirection arm="0" index="1" value="vertical"/> <celldesigner:lineDirection arm="1" index="0" value="horizontal"/> <celldesigner:lineDirection arm="1" index="1" value="vertical"/> <celldesigner:lineDirection arm="2" index="0" value="vertical"/> <celldesigner:lineDirection arm="2" index="1" value="horizontal"/> <celldesigner:lineDirection arm="2" index="2" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:editPoints num0="1" num1="1" num2="2" tShapeIndex="0">0.998076702297781,0.04381322435256285 0.9762808743851181,-0.15217269365740504 0.4155533995675249,0.0 0.4155533995675249,1.9184653865522705E-13 0.6497613800118298,0.23106568521000304</celldesigner:editPoints> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00048" species="s33"> <annotation> <celldesigner:extension> <celldesigner:alias>sa24</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> <speciesReference metaid="CDMT00049" species="s9"> <annotation> <celldesigner:extension> <celldesigner:alias>sa33</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00050" species="s163"> <annotation> <celldesigner:extension> <celldesigner:alias>csa1</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> <reaction metaid="re53" id="re17" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>TRANSPORT</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s11" alias="sa10"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s29" alias="sa27"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="square" rectangleIndex="2"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="vertical"/> <celldesigner:lineDirection index="1" value="horizontal"/> <celldesigner:lineDirection index="2" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:editPoints>0.022456298621392146,-0.05570929345128217 0.8826802997496455,0.2910451859879206</celldesigner:editPoints> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00051" species="s11"> <annotation> <celldesigner:extension> <celldesigner:alias>sa10</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00052" species="s29"> <annotation> <celldesigner:extension> <celldesigner:alias>sa27</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> <reaction metaid="re54" id="re18" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s16" alias="sa19"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s58" alias="sa20"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:listOfReactantLinks> <celldesigner:reactantLink reactant="s29" alias="sa27" targetLineIndex="-1,0"> <celldesigner:linkAnchor position="E"/> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="horizontal"/> <celldesigner:lineDirection index="1" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:editPoints>0.9815178140794165,0.1346870250773271</celldesigner:editPoints> <celldesigner:line width="1.0" color="ff000000" type="Straight"/> </celldesigner:reactantLink> </celldesigner:listOfReactantLinks> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="2.0" color="ff33cc00"/> <celldesigner:listOfModification> <celldesigner:modification type="CATALYSIS" modifiers="s26" aliases="sa50" targetLineIndex="-1,2" editPoints="-0.12586085596188124,-0.11812063327376388 0.34244641037747225,-0.6171151929967285"> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="vertical"/> <celldesigner:lineDirection index="1" value="horizontal"/> <celldesigner:lineDirection index="2" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s26" alias="sa50"> <celldesigner:linkAnchor position="SSE"/> </celldesigner:linkTarget> <celldesigner:line width="3.0" color="ffff3333"/> </celldesigner:modification> </celldesigner:listOfModification> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00053" species="s16"> <annotation> <celldesigner:extension> <celldesigner:alias>sa19</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> <speciesReference metaid="CDMT00054" species="s29"> <annotation> <celldesigner:extension> <celldesigner:alias>sa27</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00055" species="s58"> <annotation> <celldesigner:extension> <celldesigner:alias>sa20</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid="CDMT00056" species="s26"> <annotation> <celldesigner:extension> <celldesigner:alias>sa50</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> </listOfModifiers> </reaction> <reaction metaid="re55" id="re19" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s44" alias="sa22"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s123" alias="sa21"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> <celldesigner:listOfModification> <celldesigner:modification type="CATALYSIS" modifiers="s58" aliases="sa20" targetLineIndex="-1,3" editPoints="0.30349658852363426,7.869127897066619E-4 0.3035033112070664,-0.0018058923003643201"> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="vertical"/> <celldesigner:lineDirection index="1" value="horizontal"/> <celldesigner:lineDirection index="2" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s58" alias="sa20"> <celldesigner:linkAnchor position="NNE"/> </celldesigner:linkTarget> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:modification> </celldesigner:listOfModification> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00057" species="s44"> <annotation> <celldesigner:extension> <celldesigner:alias>sa22</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00058" species="s123"> <annotation> <celldesigner:extension> <celldesigner:alias>sa21</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid="CDMT00059" species="s58"> <annotation> <celldesigner:extension> <celldesigner:alias>sa20</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> </listOfModifiers> </reaction> <reaction metaid="re56" id="re20" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s123" alias="sa21"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s35" alias="sa14"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00060" species="s123"> <annotation> <celldesigner:extension> <celldesigner:alias>sa21</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00061" species="s35"> <annotation> <celldesigner:extension> <celldesigner:alias>sa14</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> <reaction metaid="re64" id="re21" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s137" alias="sa8"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s136" alias="sa18"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="2.0" color="ff33cc00"/> <celldesigner:listOfModification> <celldesigner:modification type="CATALYSIS" modifiers="s19" aliases="sa42" targetLineIndex="-1,4" editPoints="-0.02119699044055645,-0.051061738405512314 0.831806211002532,-0.4051644632904392"> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="vertical"/> <celldesigner:lineDirection index="1" value="horizontal"/> <celldesigner:lineDirection index="2" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s19" alias="sa42"> <celldesigner:linkAnchor position="SSE"/> </celldesigner:linkTarget> <celldesigner:line width="3.0" color="ffff3333"/> </celldesigner:modification> </celldesigner:listOfModification> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00062" species="s137"> <annotation> <celldesigner:extension> <celldesigner:alias>sa8</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00063" species="s136"> <annotation> <celldesigner:extension> <celldesigner:alias>sa18</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid="CDMT00064" species="s19"> <annotation> <celldesigner:extension> <celldesigner:alias>sa42</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> </listOfModifiers> </reaction> <reaction metaid="re65" id="re22" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s44" alias="sa17"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s138" alias="sa16"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> <celldesigner:listOfModification> <celldesigner:modification type="CATALYSIS" modifiers="s136" aliases="sa18" targetLineIndex="-1,3" editPoints="0.6855906222048382,-0.01589646528264943 0.6861279483516913,0.0072776027130823095"> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="vertical"/> <celldesigner:lineDirection index="1" value="horizontal"/> <celldesigner:lineDirection index="2" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s136" alias="sa18"> <celldesigner:linkAnchor position="N"/> </celldesigner:linkTarget> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:modification> </celldesigner:listOfModification> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00066" species="s44"> <annotation> <celldesigner:extension> <celldesigner:alias>sa17</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00067" species="s138"> <annotation> <celldesigner:extension> <celldesigner:alias>sa16</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid="CDMT00068" species="s136"> <annotation> <celldesigner:extension> <celldesigner:alias>sa18</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> </listOfModifiers> </reaction> <reaction metaid="re66" id="re23" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s138" alias="sa16"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s13" alias="sa7"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00069" species="s138"> <annotation> <celldesigner:extension> <celldesigner:alias>sa16</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00070" species="s13"> <annotation> <celldesigner:extension> <celldesigner:alias>sa7</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> <reaction metaid="re67" id="re24" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s3" alias="sa15"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s139" alias="sa6"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> <celldesigner:listOfModification> <celldesigner:modification type="CATALYSIS" modifiers="s138" aliases="sa16" targetLineIndex="-1,3"> <celldesigner:connectScheme connectPolicy="direct"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s138" alias="sa16"> <celldesigner:linkAnchor position="NNW"/> </celldesigner:linkTarget> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:modification> </celldesigner:listOfModification> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00071" species="s3"> <annotation> <celldesigner:extension> <celldesigner:alias>sa15</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00072" species="s139"> <annotation> <celldesigner:extension> <celldesigner:alias>sa6</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid="CDMT00073" species="s138"> <annotation> <celldesigner:extension> <celldesigner:alias>sa16</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> </listOfModifiers> </reaction> <reaction metaid="re68" id="re25" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s139" alias="sa6"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s17" alias="sa5"> <celldesigner:linkAnchor position="WSW"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00074" species="s139"> <annotation> <celldesigner:extension> <celldesigner:alias>sa6</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00075" species="s17"> <annotation> <celldesigner:extension> <celldesigner:alias>sa5</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> <reaction metaid="re1" id="re26" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s1" alias="sa30"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> <celldesigner:baseReactant species="s2" alias="sa29"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s6" alias="csa3"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection arm="0" index="0" value="vertical"/> <celldesigner:lineDirection arm="0" index="1" value="horizontal"/> <celldesigner:lineDirection arm="1" index="0" value="vertical"/> <celldesigner:lineDirection arm="1" index="1" value="horizontal"/> <celldesigner:lineDirection arm="2" index="0" value="horizontal"/> <celldesigner:lineDirection arm="2" index="1" value="vertical"/> <celldesigner:lineDirection arm="2" index="2" value="horizontal"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:editPoints num0="1" num1="1" num2="2" tShapeIndex="0">0.5092365427921273,0.499914678997575 0.4779466514017727,-0.49951341304874575 0.48206661136730133,0.06022150241890323 0.4974327181923712,-0.06278252022307917 0.3974042389392942,0.43965586118437994</celldesigner:editPoints> <celldesigner:line width="1.0" color="ff339900"/> <celldesigner:listOfModification> <celldesigner:modification type="CATALYSIS" modifiers="s7" aliases="sa40" targetLineIndex="2,2" editPoints="0.00846140838090026,0.03120632345987287 0.939977217209977,-0.22136862923850484"> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="vertical"/> <celldesigner:lineDirection index="1" value="horizontal"/> <celldesigner:lineDirection index="2" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s7" alias="sa40"> <celldesigner:linkAnchor position="S"/> </celldesigner:linkTarget> <celldesigner:line width="3.0" color="ffff3366"/> </celldesigner:modification> <celldesigner:modification type="INHIBITION" modifiers="s19" aliases="sa42" targetLineIndex="2,7" editPoints="0.19393801041439718,0.39538090309333596"> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="horizontal"/> <celldesigner:lineDirection index="1" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s19" alias="sa42"> <celldesigner:linkAnchor position="E"/> </celldesigner:linkTarget> <celldesigner:line width="3.0" color="ff0066ff"/> </celldesigner:modification> </celldesigner:listOfModification> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00076" species="s1"> <annotation> <celldesigner:extension> <celldesigner:alias>sa30</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> <speciesReference metaid="CDMT00077" species="s2"> <annotation> <celldesigner:extension> <celldesigner:alias>sa29</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00078" species="s6"> <annotation> <celldesigner:extension> <celldesigner:alias>csa3</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid="CDMT00079" species="s7"> <annotation> <celldesigner:extension> <celldesigner:alias>sa40</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> <modifierSpeciesReference metaid="CDMT00080" species="s19"> <annotation> <celldesigner:extension> <celldesigner:alias>sa42</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> </listOfModifiers> </reaction> <reaction metaid="CDMT00113" id="re27" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s3" alias="sa13"/> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s10" alias="sa11"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00081" species="s3"> <annotation> <celldesigner:extension> <celldesigner:alias>sa13</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00082" species="s10"> <annotation> <celldesigner:extension> <celldesigner:alias>sa11</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> <reaction metaid="CDMT00116" id="re28" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s161" alias="csa2"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s20" alias="sa69"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> <celldesigner:listOfModification> <celldesigner:modification type="MODULATION" modifiers="s7" aliases="sa40" targetLineIndex="-1,4" editPoints="0.8515735210397952,-0.35552223461223986"> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="horizontal"/> <celldesigner:lineDirection index="1" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s7" alias="sa40"> <celldesigner:linkAnchor position="SE"/> </celldesigner:linkTarget> <celldesigner:line width="3.0" color="ffff3366"/> </celldesigner:modification> </celldesigner:listOfModification> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00083" species="s161"> <annotation> <celldesigner:extension> <celldesigner:alias>csa2</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00084" species="s20"> <annotation> <celldesigner:extension> <celldesigner:alias>sa69</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid="CDMT00085" species="s7"> <annotation> <celldesigner:extension> <celldesigner:alias>sa40</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> </listOfModifiers> </reaction> <reaction metaid="re42" id="re29" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s42" alias="sa57"> <celldesigner:linkAnchor position="NNE"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s30" alias="sa45"> <celldesigner:linkAnchor position="SSW"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="square" rectangleIndex="1"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="vertical"/> <celldesigner:lineDirection index="1" value="horizontal"/> <celldesigner:lineDirection index="2" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:editPoints>0.47093290847950886,0.02908947754693525 0.4747339258737653,-0.03244563162679892</celldesigner:editPoints> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00086" species="s42"> <annotation> <celldesigner:extension> <celldesigner:alias>sa57</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00087" species="s30"> <annotation> <celldesigner:extension> <celldesigner:alias>sa45</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> <reaction metaid="CDMT00123" id="re30" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s11" alias="sa10"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s20" alias="sa4"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00088" species="s11"> <annotation> <celldesigner:extension> <celldesigner:alias>sa10</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00089" species="s20"> <annotation> <celldesigner:extension> <celldesigner:alias>sa4</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> <reaction metaid="CDMT00126" id="re31" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s10" alias="sa11"> <celldesigner:linkAnchor position="ENE"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s20" alias="sa3"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00090" species="s10"> <annotation> <celldesigner:extension> <celldesigner:alias>sa11</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00091" species="s20"> <annotation> <celldesigner:extension> <celldesigner:alias>sa3</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> <reaction metaid="CDMT00129" id="re32" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s33" alias="sa24"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s20" alias="sa12"> <celldesigner:linkAnchor position="WNW"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00092" species="s33"> <annotation> <celldesigner:extension> <celldesigner:alias>sa24</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00093" species="s20"> <annotation> <celldesigner:extension> <celldesigner:alias>sa12</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> <reaction metaid="re44" id="re33" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s15" alias="sa25"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s20" alias="sa26"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00094" species="s15"> <annotation> <celldesigner:extension> <celldesigner:alias>sa25</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00095" species="s20"> <annotation> <celldesigner:extension> <celldesigner:alias>sa26</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> <reaction metaid="re46" id="re34" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s18" alias="sa63"> <celldesigner:linkAnchor position="ESE"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s24" alias="sa62"> <celldesigner:linkAnchor position="WSW"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> <celldesigner:listOfModification> <celldesigner:modification type="CATALYSIS" modifiers="s7" aliases="sa40" targetLineIndex="-1,3" editPoints="0.1413559144299672,0.31505043265610216 0.9737797276812086,-0.05843906971779844"> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="vertical"/> <celldesigner:lineDirection index="1" value="horizontal"/> <celldesigner:lineDirection index="2" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s7" alias="sa40"> <celldesigner:linkAnchor position="N"/> </celldesigner:linkTarget> <celldesigner:line width="3.0" color="ffff0033"/> </celldesigner:modification> </celldesigner:listOfModification> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00096" species="s18"> <annotation> <celldesigner:extension> <celldesigner:alias>sa63</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00097" species="s24"> <annotation> <celldesigner:extension> <celldesigner:alias>sa62</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid="CDMT00098" species="s7"> <annotation> <celldesigner:extension> <celldesigner:alias>sa40</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> </listOfModifiers> </reaction> <reaction metaid="re47" id="re35" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s24" alias="sa62"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s20" alias="sa61"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="square" rectangleIndex="2"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="horizontal"/> <celldesigner:lineDirection index="1" value="vertical"/> <celldesigner:lineDirection index="2" value="horizontal"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:editPoints>0.6349729656442467,-5.277368398381166E-4 0.6349736563992738,3.033796073402262E-4</celldesigner:editPoints> <celldesigner:line width="8.0" color="ff009999"/> <celldesigner:listOfModification> <celldesigner:modification type="CATALYSIS" modifiers="s159" aliases="sa53" targetLineIndex="-1,6" editPoints="0.7611327278165185,-3.16462745463042E-4 0.7611329006883807,9.93158424122953E-5"> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="vertical"/> <celldesigner:lineDirection index="1" value="horizontal"/> <celldesigner:lineDirection index="2" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s159" alias="sa53"> <celldesigner:linkAnchor position="N"/> </celldesigner:linkTarget> <celldesigner:line width="3.0" color="ffff3366"/> </celldesigner:modification> </celldesigner:listOfModification> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00100" species="s24"> <annotation> <celldesigner:extension> <celldesigner:alias>sa62</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00101" species="s20"> <annotation> <celldesigner:extension> <celldesigner:alias>sa61</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid="CDMT00102" species="s159"> <annotation> <celldesigner:extension> <celldesigner:alias>sa53</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> </listOfModifiers> </reaction> <reaction metaid="re23" id="re36" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s32" alias="sa44"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s21" alias="sa52"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="square" rectangleIndex="2"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="vertical"/> <celldesigner:lineDirection index="1" value="horizontal"/> <celldesigner:lineDirection index="2" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:editPoints>0.11109417860408266,-0.0013715330691823624 0.11124657116731473,0.010972264553494426</celldesigner:editPoints> <celldesigner:line width="2.0" color="ff339900"/> <celldesigner:listOfModification> <celldesigner:modification type="CATALYSIS" modifiers="s7" aliases="sa40" targetLineIndex="-1,6" editPoints="0.748768866606984,-0.43372116734957267"> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="vertical"/> <celldesigner:lineDirection index="1" value="horizontal"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s7" alias="sa40"> <celldesigner:linkAnchor position="NNE"/> </celldesigner:linkTarget> <celldesigner:line width="3.0" color="ffff3366"/> </celldesigner:modification> </celldesigner:listOfModification> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00104" species="s32"> <annotation> <celldesigner:extension> <celldesigner:alias>sa44</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00105" species="s21"> <annotation> <celldesigner:extension> <celldesigner:alias>sa52</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid="CDMT00106" species="s7"> <annotation> <celldesigner:extension> <celldesigner:alias>sa40</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> </listOfModifiers> </reaction> <reaction metaid="re24" id="re37"> <annotation> <celldesigner:extension> <celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s21" alias="sa52"> <celldesigner:linkAnchor position="ESE"/> </celldesigner:baseReactant> <celldesigner:baseReactant species="s33" alias="sa24"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s27" alias="sa56"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection arm="0" index="0" value="vertical"/> <celldesigner:lineDirection arm="0" index="1" value="horizontal"/> <celldesigner:lineDirection arm="1" index="0" value="vertical"/> <celldesigner:lineDirection arm="1" index="1" value="horizontal"/> <celldesigner:lineDirection arm="1" index="2" value="vertical"/> <celldesigner:lineDirection arm="2" index="0" value="horizontal"/> <celldesigner:lineDirection arm="2" index="1" value="vertical"/> <celldesigner:lineDirection arm="2" index="2" value="horizontal"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:editPoints num0="1" num1="2" num2="2" tShapeIndex="0">0.4544461126553543,0.49792051910700685 0.37762011035973764,-0.34495533362096875 0.8325062612016811,0.15300524776489155 0.8209790345022192,-0.01701978910079749 0.8214086279068411,0.0037023935575799527 -1.6225777802958739,8.501434573599113</celldesigner:editPoints> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00107" species="s21"> <annotation> <celldesigner:extension> <celldesigner:alias>sa52</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> <speciesReference metaid="CDMT00108" species="s33"> <annotation> <celldesigner:extension> <celldesigner:alias>sa24</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00109" species="s27"> <annotation> <celldesigner:extension> <celldesigner:alias>sa56</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> <reaction metaid="re25" id="re38" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s159" alias="sa53"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s20" alias="sa54"> <celldesigner:linkAnchor position="WNW"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="horizontal"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00110" species="s159"> <annotation> <celldesigner:extension> <celldesigner:alias>sa53</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00111" species="s20"> <annotation> <celldesigner:extension> <celldesigner:alias>sa54</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> <reaction metaid="re26" id="re39" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s3" alias="sa51"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s159" alias="sa53"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> <celldesigner:listOfModification> <celldesigner:modification type="CATALYSIS" modifiers="s163" aliases="csa1" targetLineIndex="-1,7" editPoints="0.07548494443962817,0.18960817817457887 0.9386762751480813,-0.15403707102613895"> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="vertical"/> <celldesigner:lineDirection index="1" value="horizontal"/> <celldesigner:lineDirection index="2" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s163" alias="csa1"> <celldesigner:linkAnchor position="N"/> </celldesigner:linkTarget> <celldesigner:line width="3.0" color="ffff3366"/> </celldesigner:modification> <celldesigner:modification type="CATALYSIS" modifiers="s7" aliases="sa40" targetLineIndex="-1,6" editPoints="0.9134437189967404,0.2811837321434947"> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="horizontal"/> <celldesigner:lineDirection index="1" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s7" alias="sa40"> <celldesigner:linkAnchor position="NE"/> </celldesigner:linkTarget> <celldesigner:line width="3.0" color="ffff3366"/> </celldesigner:modification> </celldesigner:listOfModification> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00112" species="s3"> <annotation> <celldesigner:extension> <celldesigner:alias>sa51</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00114" species="s159"> <annotation> <celldesigner:extension> <celldesigner:alias>sa53</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid="CDMT00115" species="s163"> <annotation> <celldesigner:extension> <celldesigner:alias>csa1</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> <modifierSpeciesReference metaid="CDMT00117" species="s7"> <annotation> <celldesigner:extension> <celldesigner:alias>sa40</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> </listOfModifiers> </reaction> <reaction metaid="re30" id="re40" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s7" alias="sa40"> <celldesigner:linkAnchor position="SW"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s17" alias="sa34"> <celldesigner:linkAnchor position="ENE"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:listOfReactantLinks> <celldesigner:reactantLink reactant="s56" alias="sa39" targetLineIndex="-1,0"> <celldesigner:linkAnchor position="NNE"/> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="vertical"/> <celldesigner:lineDirection index="1" value="horizontal"/> <celldesigner:lineDirection index="2" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:editPoints>0.07495780944828478,-0.16888093502047585 0.9103777039762582,0.20192021702040552</celldesigner:editPoints> <celldesigner:line width="1.0" color="ff000000" type="Straight"/> </celldesigner:reactantLink> </celldesigner:listOfReactantLinks> <celldesigner:connectScheme connectPolicy="square" rectangleIndex="1"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="vertical"/> <celldesigner:lineDirection index="1" value="horizontal"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:editPoints>1.983716285369752E-5,-0.004453848823294915</celldesigner:editPoints> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00118" species="s7"> <annotation> <celldesigner:extension> <celldesigner:alias>sa40</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> <speciesReference metaid="CDMT00119" species="s56"> <annotation> <celldesigner:extension> <celldesigner:alias>sa39</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00120" species="s17"> <annotation> <celldesigner:extension> <celldesigner:alias>sa34</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> <reaction metaid="re50" id="re41" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s28" alias="sa47"> <celldesigner:linkAnchor position="ESE"/> </celldesigner:baseReactant> <celldesigner:baseReactant species="s43" alias="sa41"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s7" alias="sa40"> <celldesigner:linkAnchor position="NW"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection arm="0" index="0" value="vertical"/> <celldesigner:lineDirection arm="0" index="1" value="horizontal"/> <celldesigner:lineDirection arm="1" index="0" value="vertical"/> <celldesigner:lineDirection arm="1" index="1" value="horizontal"/> <celldesigner:lineDirection arm="2" index="0" value="horizontal"/> <celldesigner:lineDirection arm="2" index="1" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:editPoints num0="1" num1="1" num2="1" tShapeIndex="0">0.06046132508857616,0.23833957551592166 0.0189250567751702,-0.13626040878122625 0.7310364263736764,-0.44342098471822555 -0.4383471337235503,0.5409015723925592</celldesigner:editPoints> <celldesigner:line width="1.0" color="ff000000"/> <celldesigner:listOfModification> <celldesigner:modification type="CATALYSIS" modifiers="s24" aliases="sa62" targetLineIndex="2,4" editPoints="0.38174017152699236,0.22277565417528056 0.6357859151655267,-0.21254779313450722"> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="vertical"/> <celldesigner:lineDirection index="1" value="horizontal"/> <celldesigner:lineDirection index="2" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s24" alias="sa62"> <celldesigner:linkAnchor position="SSE"/> </celldesigner:linkTarget> <celldesigner:line width="3.0" color="ffff3333"/> </celldesigner:modification> <celldesigner:modification type="INHIBITION" modifiers="s139" aliases="sa6" targetLineIndex="2,3" editPoints="0.05769243924347106,-0.17403287025932157 0.958679122442538,0.1246470251086309"> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="vertical"/> <celldesigner:lineDirection index="1" value="horizontal"/> <celldesigner:lineDirection index="2" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s139" alias="sa6"> <celldesigner:linkAnchor position="NNE"/> </celldesigner:linkTarget> <celldesigner:line width="2.0" color="ff3366ff"/> </celldesigner:modification> </celldesigner:listOfModification> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00121" species="s28"> <annotation> <celldesigner:extension> <celldesigner:alias>sa47</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> <speciesReference metaid="CDMT00122" species="s43"> <annotation> <celldesigner:extension> <celldesigner:alias>sa41</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00124" species="s7"> <annotation> <celldesigner:extension> <celldesigner:alias>sa40</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid="CDMT00125" species="s24"> <annotation> <celldesigner:extension> <celldesigner:alias>sa62</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> <modifierSpeciesReference metaid="CDMT00127" species="s139"> <annotation> <celldesigner:extension> <celldesigner:alias>sa6</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> </listOfModifiers> </reaction> <reaction metaid="re14" id="re42" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s39" alias="sa48"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s26" alias="sa50"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00128" species="s39"> <annotation> <celldesigner:extension> <celldesigner:alias>sa48</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00130" species="s26"> <annotation> <celldesigner:extension> <celldesigner:alias>sa50</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> <reaction metaid="re15" id="re43" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s26" alias="sa50"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s38" alias="sa49"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> <celldesigner:listOfModification> <celldesigner:modification type="INHIBITION" modifiers="s19" aliases="sa42" targetLineIndex="-1,3" editPoints="0.04394956613870393,-0.07132291384209566 0.7687400201756893,0.37529689289943846"> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="vertical"/> <celldesigner:lineDirection index="1" value="horizontal"/> <celldesigner:lineDirection index="2" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s19" alias="sa42"> <celldesigner:linkAnchor position="NNE"/> </celldesigner:linkTarget> <celldesigner:line width="3.0" color="ff0066ff"/> </celldesigner:modification> </celldesigner:listOfModification> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00131" species="s26"> <annotation> <celldesigner:extension> <celldesigner:alias>sa50</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00132" species="s38"> <annotation> <celldesigner:extension> <celldesigner:alias>sa49</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid="CDMT00133" species="s19"> <annotation> <celldesigner:extension> <celldesigner:alias>sa42</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> </listOfModifiers> </reaction> <reaction metaid="re16" id="re44" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s3" alias="sa59"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s40" alias="sa60"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> <celldesigner:listOfModification> <celldesigner:modification type="CATALYSIS" modifiers="s26" aliases="sa50" targetLineIndex="-1,3"> <celldesigner:connectScheme connectPolicy="direct"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s26" alias="sa50"> <celldesigner:linkAnchor position="N"/> </celldesigner:linkTarget> <celldesigner:line width="3.0" color="ffff3333"/> </celldesigner:modification> </celldesigner:listOfModification> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00134" species="s3"> <annotation> <celldesigner:extension> <celldesigner:alias>sa59</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00135" species="s40"> <annotation> <celldesigner:extension> <celldesigner:alias>sa60</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid="CDMT00136" species="s26"> <annotation> <celldesigner:extension> <celldesigner:alias>sa50</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> </listOfModifiers> </reaction> <reaction metaid="re17" id="re45" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s40" alias="sa60"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s38" alias="sa58"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00137" species="s40"> <annotation> <celldesigner:extension> <celldesigner:alias>sa60</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00138" species="s38"> <annotation> <celldesigner:extension> <celldesigner:alias>sa58</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> <reaction metaid="re19" id="re46" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s12" alias="sa43"> <celldesigner:linkAnchor position="ESE"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s19" alias="sa42"> <celldesigner:linkAnchor position="WSW"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="square" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="horizontal"/> <celldesigner:lineDirection index="1" value="vertical"/> <celldesigner:lineDirection index="2" value="horizontal"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:editPoints>0.49999999999999645,0.0 0.49999999999999645,0.0</celldesigner:editPoints> <celldesigner:line width="1.0" color="ff000000"/> <celldesigner:listOfModification> <celldesigner:modification type="CATALYSIS" modifiers="s7" aliases="sa40" targetLineIndex="-1,3" editPoints="-0.08231000317224935,-0.9612334270499203 0.5048813091285547,-1.0115143654964007 0.5425453927528752,-0.5749832974018125 0.9812751317965491,-0.6139999708895996 1.0364660897732396,-0.0031225755164661084"> <celldesigner:connectScheme connectPolicy="direct"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="horizontal"/> <celldesigner:lineDirection index="1" value="vertical"/> <celldesigner:lineDirection index="2" value="horizontal"/> <celldesigner:lineDirection index="3" value="unknown"/> <celldesigner:lineDirection index="4" value="unknown"/> <celldesigner:lineDirection index="5" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s7" alias="sa40"> <celldesigner:linkAnchor position="E"/> </celldesigner:linkTarget> <celldesigner:line width="3.0" color="ffff3366"/> </celldesigner:modification> </celldesigner:listOfModification> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00139" species="s12"> <annotation> <celldesigner:extension> <celldesigner:alias>sa43</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00140" species="s19"> <annotation> <celldesigner:extension> <celldesigner:alias>sa42</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid="CDMT00141" species="s7"> <annotation> <celldesigner:extension> <celldesigner:alias>sa40</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> </listOfModifiers> </reaction> <reaction metaid="re20" id="re47" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s19" alias="sa42"> <celldesigner:linkAnchor position="WNW"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s12" alias="sa43"> <celldesigner:linkAnchor position="ENE"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00142" species="s19"> <annotation> <celldesigner:extension> <celldesigner:alias>sa42</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00143" species="s12"> <annotation> <celldesigner:extension> <celldesigner:alias>sa43</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> <reaction metaid="re49" id="re48" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s31" alias="sa66"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s37" alias="sa65"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00144" species="s31"> <annotation> <celldesigner:extension> <celldesigner:alias>sa66</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00145" species="s37"> <annotation> <celldesigner:extension> <celldesigner:alias>sa65</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> <reaction metaid="CDMT00146" id="re49" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s165" alias="sa67"> <celldesigner:linkAnchor position="ENE"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s31" alias="sa66"> <celldesigner:linkAnchor position="WNW"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="square" rectangleIndex="1"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="horizontal"/> <celldesigner:lineDirection index="1" value="vertical"/> <celldesigner:lineDirection index="2" value="horizontal"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:editPoints>0.43968150047697385,-0.013933391327692085 0.4406847324537697,0.01772455400061035</celldesigner:editPoints> <celldesigner:line width="1.0" color="ff000000"/> <celldesigner:listOfModification> <celldesigner:modification type="INHIBITION" modifiers="s40" aliases="sa60" targetLineIndex="-1,6" editPoints="0.05677899993956603,0.03658543451335927 -0.2632448321593732,0.5088238588226809 0.3633781103749141,0.946901305703778 1.0146921510301121,0.010404316839808692"> <celldesigner:connectScheme connectPolicy="direct"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> <celldesigner:lineDirection index="1" value="unknown"/> <celldesigner:lineDirection index="2" value="unknown"/> <celldesigner:lineDirection index="3" value="unknown"/> <celldesigner:lineDirection index="4" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s40" alias="sa60"> <celldesigner:linkAnchor position="NNW"/> </celldesigner:linkTarget> <celldesigner:line width="2.0" color="ff0033ff"/> </celldesigner:modification> <celldesigner:modification type="CATALYSIS" modifiers="s24" aliases="sa62" targetLineIndex="-1,7"> <celldesigner:connectScheme connectPolicy="direct"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s24" alias="sa62"> <celldesigner:linkAnchor position="N"/> </celldesigner:linkTarget> <celldesigner:line width="3.0" color="ffff0066"/> </celldesigner:modification> </celldesigner:listOfModification> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00147" species="s165"> <annotation> <celldesigner:extension> <celldesigner:alias>sa67</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00148" species="s31"> <annotation> <celldesigner:extension> <celldesigner:alias>sa66</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid="CDMT00149" species="s40"> <annotation> <celldesigner:extension> <celldesigner:alias>sa60</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> <modifierSpeciesReference metaid="CDMT00150" species="s24"> <annotation> <celldesigner:extension> <celldesigner:alias>sa62</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> </listOfModifiers> </reaction> <reaction metaid="CDMT00099" id="re50" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s24" alias="sa62"> <celldesigner:linkAnchor position="WNW"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s18" alias="sa63"> <celldesigner:linkAnchor position="ENE"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> <celldesigner:listOfModification> <celldesigner:modification type="CATALYSIS" modifiers="s40" aliases="sa60" targetLineIndex="-1,3" editPoints="0.035235502632518845,0.03622838217036917 -0.2999276069409744,0.3510150700694572 0.17798238931225763,0.864831970994048 1.0486290661216673,0.05200122926784567"> <celldesigner:connectScheme connectPolicy="direct"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="vertical"/> <celldesigner:lineDirection index="1" value="unknown"/> <celldesigner:lineDirection index="2" value="unknown"/> <celldesigner:lineDirection index="3" value="horizontal"/> <celldesigner:lineDirection index="4" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s40" alias="sa60"> <celldesigner:linkAnchor position="NE"/> </celldesigner:linkTarget> <celldesigner:line width="3.0" color="ffff0033"/> </celldesigner:modification> </celldesigner:listOfModification> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00103" species="s24"> <annotation> <celldesigner:extension> <celldesigner:alias>sa62</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00151" species="s18"> <annotation> <celldesigner:extension> <celldesigner:alias>sa63</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid="CDMT00152" species="s40"> <annotation> <celldesigner:extension> <celldesigner:alias>sa60</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> </listOfModifiers> </reaction> <reaction metaid="re51" id="re51" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s28" alias="sa47"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseReactant> <celldesigner:baseReactant species="s43" alias="sa41"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s41" alias="sa89"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection arm="0" index="0" value="unknown"/> <celldesigner:lineDirection arm="1" index="0" value="unknown"/> <celldesigner:lineDirection arm="2" index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:editPoints num0="0" num1="0" num2="0" tShapeIndex="0">0.3055555555555554,0.3125</celldesigner:editPoints> <celldesigner:line width="1.0" color="ff000000"/> <celldesigner:listOfModification> <celldesigner:modification type="CATALYSIS" modifiers="s139" aliases="sa6" targetLineIndex="2,3" editPoints="0.19964994995550184,-0.28362861886671364 0.8683253627874998,0.18706088081004268"> <celldesigner:connectScheme connectPolicy="square"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="vertical"/> <celldesigner:lineDirection index="1" value="horizontal"/> <celldesigner:lineDirection index="2" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:linkTarget species="s139" alias="sa6"> <celldesigner:linkAnchor position="NE"/> </celldesigner:linkTarget> <celldesigner:line width="3.0" color="ffff3333"/> </celldesigner:modification> </celldesigner:listOfModification> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00153" species="s28"> <annotation> <celldesigner:extension> <celldesigner:alias>sa47</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> <speciesReference metaid="CDMT00154" species="s43"> <annotation> <celldesigner:extension> <celldesigner:alias>sa41</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00155" species="s41"> <annotation> <celldesigner:extension> <celldesigner:alias>sa89</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid="CDMT00156" species="s139"> <annotation> <celldesigner:extension> <celldesigner:alias>sa6</celldesigner:alias> </celldesigner:extension> </annotation> </modifierSpeciesReference> </listOfModifiers> </reaction> <reaction metaid="CDMT00162" id="re52" reversible="false"> <annotation> <celldesigner:extension> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s29" alias="sa27"> <celldesigner:linkAnchor position="SSW"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s11" alias="sa10"> <celldesigner:linkAnchor position="NNW"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="square" rectangleIndex="2"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="vertical"/> <celldesigner:lineDirection index="1" value="horizontal"/> <celldesigner:lineDirection index="2" value="vertical"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:editPoints>0.06988799943587343,-0.1733772397196014 0.9301120005641268,0.17337723971960095</celldesigner:editPoints> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00163" species="s29"> <annotation> <celldesigner:extension> <celldesigner:alias>sa27</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00164" species="s11"> <annotation> <celldesigner:extension> <celldesigner:alias>sa10</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> </reaction> </listOfReactions> </model> </sbml>