<?xml version="1.0" encoding="UTF-8"?> <!-- Created by COPASI version 4.7 (Build 34) on 2011-11-08 14:23 with libSBML version 4.2.0. --> <sbml xmlns="http://www.sbml.org/sbml/level2/version4" level="2" version="4"> <model metaid="COPASI1" id="Model_1" name="Glyolysis and pyruvate metabolism of S. pyogenes"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI1"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2010-09-20T14:34:26Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> <CopasiMT:is rdf:resource="urn:miriam:kegg.pathway:soz00010"/> <CopasiMT:is rdf:resource="urn:miriam:kegg.pathway:soz00620"/> </rdf:Description> </rdf:RDF> </COPASI> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#COPASI1"> <bqbiol:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:kegg.pathway:soz00010"/> </rdf:Bag> </bqbiol:is> <bqbiol:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:kegg.pathway:soz00620"/> </rdf:Bag> </bqbiol:is> </rdf:Description> </rdf:RDF> </annotation> <listOfFunctionDefinitions> <functionDefinition id="function_12" name="Hill Cooperativity"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <lambda> <bvar> <ci> substrate </ci> </bvar> <bvar> <ci> Shalve </ci> </bvar> <bvar> <ci> V </ci> </bvar> <bvar> <ci> h </ci> </bvar> <apply> <divide/> <apply> <times/> <ci> V </ci> <apply> <power/> <ci> substrate </ci> <ci> h </ci> </apply> </apply> <apply> <plus/> <apply> <power/> <ci> Shalve </ci> <ci> h </ci> </apply> <apply> <power/> <ci> substrate </ci> <ci> h </ci> </apply> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition id="function_16" name="CK 2S 2P 1A 1I irrev"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <lambda> <bvar> <ci> S1 </ci> </bvar> <bvar> <ci> KmS1 </ci> </bvar> <bvar> <ci> S2 </ci> </bvar> <bvar> <ci> KmS2 </ci> </bvar> <bvar> <ci> P1 </ci> </bvar> <bvar> <ci> KmP1 </ci> </bvar> <bvar> <ci> P2 </ci> </bvar> <bvar> <ci> KmP2 </ci> </bvar> <bvar> <ci> KmI </ci> </bvar> <bvar> <ci> I </ci> </bvar> <bvar> <ci> A </ci> </bvar> <bvar> <ci> KmA </ci> </bvar> <bvar> <ci> Vmax </ci> </bvar> <apply> <times/> <apply> <divide/> <ci> KmI </ci> <apply> <plus/> <ci> KmI </ci> <ci> I </ci> </apply> </apply> <apply> <divide/> <ci> A </ci> <apply> <plus/> <ci> KmA </ci> <ci> A </ci> </apply> </apply> <apply> <divide/> <apply> <times/> <ci> Vmax </ci> <apply> <divide/> <ci> S1 </ci> <ci> KmS1 </ci> </apply> <apply> <divide/> <ci> S2 </ci> <ci> KmS2 </ci> </apply> </apply> <apply> <minus/> <apply> <plus/> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S1 </ci> <ci> KmS1 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S2 </ci> <ci> KmS2 </ci> </apply> </apply> </apply> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P1 </ci> <ci> KmP1 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P2 </ci> <ci> KmP2 </ci> </apply> </apply> </apply> </apply> <cn> 1 </cn> </apply> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition metaid="COPASI50" id="function_2" name="CK 2S 2P irrev"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI50"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2010-10-22T15:34:34Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <math xmlns="http://www.w3.org/1998/Math/MathML"> <lambda> <bvar> <ci> S1 </ci> </bvar> <bvar> <ci> KmS1 </ci> </bvar> <bvar> <ci> S2 </ci> </bvar> <bvar> <ci> KmS2 </ci> </bvar> <bvar> <ci> P1 </ci> </bvar> <bvar> <ci> KmP1 </ci> </bvar> <bvar> <ci> P2 </ci> </bvar> <bvar> <ci> KmP2 </ci> </bvar> <bvar> <ci> Vmax </ci> </bvar> <apply> <divide/> <apply> <times/> <ci> Vmax </ci> <apply> <divide/> <ci> S1 </ci> <ci> KmS1 </ci> </apply> <apply> <divide/> <ci> S2 </ci> <ci> KmS2 </ci> </apply> </apply> <apply> <minus/> <apply> <plus/> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S1 </ci> <ci> KmS1 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S2 </ci> <ci> KmS2 </ci> </apply> </apply> </apply> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P1 </ci> <ci> KmP1 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P2 </ci> <ci> KmP2 </ci> </apply> </apply> </apply> </apply> <cn> 1 </cn> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition id="function_4" name="CK 1S 2P 1A irrev"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <lambda> <bvar> <ci> S </ci> </bvar> <bvar> <ci> KmS </ci> </bvar> <bvar> <ci> P1 </ci> </bvar> <bvar> <ci> KmP1 </ci> </bvar> <bvar> <ci> P2 </ci> </bvar> <bvar> <ci> KmP2 </ci> </bvar> <bvar> <ci> A </ci> </bvar> <bvar> <ci> KmA </ci> </bvar> <bvar> <ci> Vmax </ci> </bvar> <apply> <times/> <apply> <divide/> <ci> A </ci> <apply> <plus/> <ci> KmA </ci> <ci> A </ci> </apply> </apply> <apply> <divide/> <apply> <times/> <ci> Vmax </ci> <apply> <divide/> <ci> S </ci> <ci> KmS </ci> </apply> </apply> <apply> <plus/> <apply> <divide/> <ci> S </ci> <ci> KmS </ci> </apply> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P1 </ci> <ci> KmP1 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P2 </ci> <ci> KmP2 </ci> </apply> </apply> </apply> </apply> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition id="function_14" name="CK 2S 2P 2I irrev"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <lambda> <bvar> <ci> KmI1 </ci> </bvar> <bvar> <ci> I1 </ci> </bvar> <bvar> <ci> KmI2 </ci> </bvar> <bvar> <ci> I2 </ci> </bvar> <bvar> <ci> Vmax </ci> </bvar> <bvar> <ci> S1 </ci> </bvar> <bvar> <ci> KmS1 </ci> </bvar> <bvar> <ci> S2 </ci> </bvar> <bvar> <ci> KmS2 </ci> </bvar> <bvar> <ci> P1 </ci> </bvar> <bvar> <ci> KmP1 </ci> </bvar> <bvar> <ci> P2 </ci> </bvar> <bvar> <ci> KmP2 </ci> </bvar> <apply> <times/> <apply> <divide/> <ci> KmI1 </ci> <apply> <plus/> <ci> KmI1 </ci> <ci> I1 </ci> </apply> </apply> <apply> <divide/> <ci> KmI2 </ci> <apply> <plus/> <ci> KmI2 </ci> <ci> I2 </ci> </apply> </apply> <apply> <divide/> <apply> <times/> <ci> Vmax </ci> <apply> <divide/> <ci> S1 </ci> <ci> KmS1 </ci> </apply> <apply> <divide/> <ci> S2 </ci> <ci> KmS2 </ci> </apply> </apply> <apply> <minus/> <apply> <plus/> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S1 </ci> <ci> KmS1 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S2 </ci> <ci> KmS2 </ci> </apply> </apply> </apply> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P1 </ci> <ci> KmP1 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P2 </ci> <ci> KmP2 </ci> </apply> </apply> </apply> </apply> <cn> 1 </cn> </apply> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition id="diffusion" name="diffusion"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <lambda> <bvar> <ci> k </ci> </bvar> <bvar> <ci> S </ci> </bvar> <bvar> <ci> P </ci> </bvar> <apply> <times/> <ci> k </ci> <apply> <minus/> <ci> S </ci> <ci> P </ci> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition id="function_15" name="CK 1S 1P 1I irrev"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <lambda> <bvar> <ci> KmI </ci> </bvar> <bvar> <ci> I </ci> </bvar> <bvar> <ci> Vmax </ci> </bvar> <bvar> <ci> S </ci> </bvar> <bvar> <ci> KmS </ci> </bvar> <bvar> <ci> P </ci> </bvar> <bvar> <ci> KmP </ci> </bvar> <apply> <times/> <apply> <divide/> <ci> KmI </ci> <apply> <plus/> <ci> KmI </ci> <ci> I </ci> </apply> </apply> <apply> <divide/> <apply> <times/> <ci> Vmax </ci> <apply> <divide/> <ci> S </ci> <ci> KmS </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S </ci> <ci> KmS </ci> </apply> <apply> <divide/> <ci> P </ci> <ci> KmP </ci> </apply> </apply> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition id="function_17" name="CK 1S 2P 1A 1I irrev"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <lambda> <bvar> <ci> KmI </ci> </bvar> <bvar> <ci> I </ci> </bvar> <bvar> <ci> A </ci> </bvar> <bvar> <ci> KmA </ci> </bvar> <bvar> <ci> Vmax </ci> </bvar> <bvar> <ci> S </ci> </bvar> <bvar> <ci> KmS </ci> </bvar> <bvar> <ci> P1 </ci> </bvar> <bvar> <ci> KmP1 </ci> </bvar> <bvar> <ci> P2 </ci> </bvar> <bvar> <ci> KmP2 </ci> </bvar> <apply> <times/> <apply> <divide/> <ci> KmI </ci> <apply> <plus/> <ci> KmI </ci> <ci> I </ci> </apply> </apply> <apply> <divide/> <ci> A </ci> <apply> <plus/> <ci> KmA </ci> <ci> A </ci> </apply> </apply> <apply> <divide/> <apply> <times/> <ci> Vmax </ci> <apply> <divide/> <ci> S </ci> <ci> KmS </ci> </apply> </apply> <apply> <plus/> <apply> <divide/> <ci> S </ci> <ci> KmS </ci> </apply> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P1 </ci> <ci> KmP1 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P2 </ci> <ci> KmP2 </ci> </apply> </apply> </apply> </apply> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition id="function_1" name="CK 3S 3P irrev"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <lambda> <bvar> <ci> Vmax </ci> </bvar> <bvar> <ci> S1 </ci> </bvar> <bvar> <ci> KmS1 </ci> </bvar> <bvar> <ci> S2 </ci> </bvar> <bvar> <ci> KmS2 </ci> </bvar> <bvar> <ci> S3 </ci> </bvar> <bvar> <ci> KmS3 </ci> </bvar> <bvar> <ci> P1 </ci> </bvar> <bvar> <ci> KmP1 </ci> </bvar> <bvar> <ci> P2 </ci> </bvar> <bvar> <ci> KmP2 </ci> </bvar> <bvar> <ci> P3 </ci> </bvar> <bvar> <ci> KmP3 </ci> </bvar> <apply> <divide/> <apply> <times/> <ci> Vmax </ci> <apply> <divide/> <ci> S1 </ci> <ci> KmS1 </ci> </apply> <apply> <divide/> <ci> S2 </ci> <ci> KmS2 </ci> </apply> <apply> <divide/> <ci> S3 </ci> <ci> KmS3 </ci> </apply> </apply> <apply> <minus/> <apply> <plus/> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S1 </ci> <ci> KmS1 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S2 </ci> <ci> KmS2 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S3 </ci> <ci> KmS3 </ci> </apply> </apply> </apply> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P1 </ci> <ci> KmP1 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P2 </ci> <ci> KmP2 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P3 </ci> <ci> KmP3 </ci> </apply> </apply> </apply> </apply> <cn> 1 </cn> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition metaid="COPASI51" id="function_11" name="CK 2S (double) 3P (double) 1I irrev"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI51"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2010-10-22T15:35:28Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <math xmlns="http://www.w3.org/1998/Math/MathML"> <lambda> <bvar> <ci> KmI </ci> </bvar> <bvar> <ci> I </ci> </bvar> <bvar> <ci> Vmax </ci> </bvar> <bvar> <ci> S1 </ci> </bvar> <bvar> <ci> KmS1 </ci> </bvar> <bvar> <ci> S2 </ci> </bvar> <bvar> <ci> KmS2 </ci> </bvar> <bvar> <ci> S3 </ci> </bvar> <bvar> <ci> P1 </ci> </bvar> <bvar> <ci> KmP1 </ci> </bvar> <bvar> <ci> P2 </ci> </bvar> <bvar> <ci> KmP2 </ci> </bvar> <bvar> <ci> P4 </ci> </bvar> <bvar> <ci> KmP4 </ci> </bvar> <apply> <times/> <apply> <divide/> <ci> KmI </ci> <apply> <plus/> <ci> KmI </ci> <ci> I </ci> </apply> </apply> <apply> <divide/> <apply> <times/> <ci> Vmax </ci> <apply> <divide/> <ci> S1 </ci> <ci> KmS1 </ci> </apply> <apply> <divide/> <ci> S2 </ci> <ci> KmS2 </ci> </apply> <apply> <divide/> <ci> S3 </ci> <ci> KmS2 </ci> </apply> </apply> <apply> <minus/> <apply> <plus/> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S1 </ci> <ci> KmS1 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S2 </ci> <ci> KmS2 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> S2 </ci> <ci> KmS2 </ci> </apply> <cn> 2 </cn> </apply> </apply> </apply> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P1 </ci> <ci> KmP1 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P2 </ci> <ci> KmP2 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P2 </ci> <ci> KmP2 </ci> </apply> <cn> 2 </cn> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P4 </ci> <ci> KmP4 </ci> </apply> </apply> </apply> </apply> <cn> 1 </cn> </apply> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition id="function_10" name="CK 3S 3P 1I irrev"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <lambda> <bvar> <ci> KmI </ci> </bvar> <bvar> <ci> I </ci> </bvar> <bvar> <ci> Vmax </ci> </bvar> <bvar> <ci> S1 </ci> </bvar> <bvar> <ci> KmS1 </ci> </bvar> <bvar> <ci> S2 </ci> </bvar> <bvar> <ci> KmS2 </ci> </bvar> <bvar> <ci> S3 </ci> </bvar> <bvar> <ci> KmS3 </ci> </bvar> <bvar> <ci> P1 </ci> </bvar> <bvar> <ci> KmP1 </ci> </bvar> <bvar> <ci> P2 </ci> </bvar> <bvar> <ci> KmP2 </ci> </bvar> <bvar> <ci> P3 </ci> </bvar> <bvar> <ci> kmP3 </ci> </bvar> <apply> <times/> <apply> <divide/> <ci> KmI </ci> <apply> <plus/> <ci> KmI </ci> <ci> I </ci> </apply> </apply> <apply> <divide/> <apply> <times/> <ci> Vmax </ci> <apply> <divide/> <ci> S1 </ci> <ci> KmS1 </ci> </apply> <apply> <divide/> <ci> S2 </ci> <ci> KmS2 </ci> </apply> <apply> <divide/> <ci> S3 </ci> <ci> KmS3 </ci> </apply> </apply> <apply> <minus/> <apply> <plus/> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S1 </ci> <ci> KmS1 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S2 </ci> <ci> KmS2 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S3 </ci> <ci> KmS3 </ci> </apply> </apply> </apply> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P1 </ci> <ci> KmP1 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P2 </ci> <ci> KmP2 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P3 </ci> <ci> kmP3 </ci> </apply> </apply> </apply> </apply> <cn> 1 </cn> </apply> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition id="function_18" name="CK 1S 1P irrev"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <lambda> <bvar> <ci> Vmax </ci> </bvar> <bvar> <ci> S </ci> </bvar> <bvar> <ci> KmS </ci> </bvar> <bvar> <ci> P </ci> </bvar> <bvar> <ci> KmP </ci> </bvar> <apply> <divide/> <apply> <times/> <ci> Vmax </ci> <apply> <divide/> <ci> S </ci> <ci> KmS </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S </ci> <ci> KmS </ci> </apply> <apply> <divide/> <ci> P </ci> <ci> KmP </ci> </apply> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition metaid="COPASI52" id="function_19" name="CK 2S 2P (double) irrev"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI52"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2010-10-22T15:35:27Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <math xmlns="http://www.w3.org/1998/Math/MathML"> <lambda> <bvar> <ci> Vmax </ci> </bvar> <bvar> <ci> S1 </ci> </bvar> <bvar> <ci> KmS1 </ci> </bvar> <bvar> <ci> S2 </ci> </bvar> <bvar> <ci> KmS2 </ci> </bvar> <bvar> <ci> P1 </ci> </bvar> <bvar> <ci> KmP1 </ci> </bvar> <bvar> <ci> P2 </ci> </bvar> <bvar> <ci> KmP2 </ci> </bvar> <apply> <divide/> <apply> <times/> <ci> Vmax </ci> <apply> <divide/> <ci> S1 </ci> <ci> KmS1 </ci> </apply> <apply> <divide/> <ci> S2 </ci> <ci> KmS2 </ci> </apply> </apply> <apply> <minus/> <apply> <plus/> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S1 </ci> <ci> KmS1 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S2 </ci> <ci> KmS2 </ci> </apply> </apply> </apply> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P1 </ci> <ci> KmP1 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P2 </ci> <ci> KmP2 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P2 </ci> <ci> KmP2 </ci> </apply> <cn> 2 </cn> </apply> </apply> </apply> </apply> <cn> 1 </cn> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition id="function_13" name="PiT.mod2"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <lambda> <bvar> <ci> KmI </ci> </bvar> <bvar> <ci> I </ci> </bvar> <bvar> <ci> A </ci> </bvar> <bvar> <ci> KmA </ci> </bvar> <bvar> <ci> Vmax </ci> </bvar> <bvar> <ci> S </ci> </bvar> <bvar> <ci> P </ci> </bvar> <bvar> <ci> KmS </ci> </bvar> <bvar> <ci> KmP </ci> </bvar> <apply> <times/> <apply> <divide/> <ci> KmI </ci> <apply> <plus/> <ci> KmI </ci> <ci> I </ci> </apply> </apply> <apply> <divide/> <ci> A </ci> <apply> <plus/> <ci> KmA </ci> <ci> A </ci> </apply> </apply> <apply> <divide/> <apply> <times/> <ci> Vmax </ci> <apply> <minus/> <ci> S </ci> <ci> P </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S </ci> <ci> KmS </ci> </apply> <apply> <divide/> <ci> P </ci> <ci> KmP </ci> </apply> </apply> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition metaid="COPASI53" id="function_6" name="CK 2S 2P ENO"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI53"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-08-30T16:35:07Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <math xmlns="http://www.w3.org/1998/Math/MathML"> <lambda> <bvar> <ci> Vmax </ci> </bvar> <bvar> <ci> S1 </ci> </bvar> <bvar> <ci> KmS1 </ci> </bvar> <bvar> <ci> S2 </ci> </bvar> <bvar> <ci> KmS2 </ci> </bvar> <bvar> <ci> Keq </ci> </bvar> <bvar> <ci> KmP1 </ci> </bvar> <bvar> <ci> KmP2 </ci> </bvar> <bvar> <ci> P1 </ci> </bvar> <bvar> <ci> P2 </ci> </bvar> <apply> <divide/> <apply> <minus/> <apply> <times/> <ci> Vmax </ci> <apply> <divide/> <ci> S1 </ci> <ci> KmS1 </ci> </apply> <apply> <divide/> <ci> S2 </ci> <ci> KmS2 </ci> </apply> </apply> <apply> <times/> <apply> <divide/> <ci> Vmax </ci> <ci> Keq </ci> </apply> <apply> <divide/> <apply> <times/> <ci> KmP1 </ci> <ci> KmP2 </ci> </apply> <apply> <times/> <ci> KmS1 </ci> <ci> KmS2 </ci> </apply> </apply> <apply> <divide/> <ci> P1 </ci> <ci> KmP1 </ci> </apply> <apply> <divide/> <ci> P2 </ci> <ci> KmP2 </ci> </apply> </apply> </apply> <apply> <minus/> <apply> <plus/> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S1 </ci> <ci> KmS1 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S2 </ci> <ci> KmS2 </ci> </apply> </apply> </apply> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P1 </ci> <ci> KmP1 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P2 </ci> <ci> KmP2 </ci> </apply> </apply> </apply> </apply> <cn> 1 </cn> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition metaid="COPASI54" id="function_3" name="CK 1S 2P (double) FBA"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI54"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-08-30T16:37:19Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <math xmlns="http://www.w3.org/1998/Math/MathML"> <lambda> <bvar> <ci> Vmax </ci> </bvar> <bvar> <ci> S1 </ci> </bvar> <bvar> <ci> KmS1 </ci> </bvar> <bvar> <ci> Keq </ci> </bvar> <bvar> <ci> KmP1 </ci> </bvar> <bvar> <ci> P1 </ci> </bvar> <bvar> <ci> P2 </ci> </bvar> <apply> <divide/> <apply> <minus/> <apply> <times/> <ci> Vmax </ci> <apply> <divide/> <ci> S1 </ci> <ci> KmS1 </ci> </apply> </apply> <apply> <times/> <apply> <divide/> <ci> Vmax </ci> <ci> Keq </ci> </apply> <apply> <divide/> <apply> <times/> <ci> KmP1 </ci> <ci> KmP1 </ci> </apply> <ci> KmS1 </ci> </apply> <apply> <divide/> <ci> P1 </ci> <ci> KmP1 </ci> </apply> <apply> <divide/> <ci> P2 </ci> <ci> KmP1 </ci> </apply> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S1 </ci> <ci> KmS1 </ci> </apply> <apply> <divide/> <ci> P1 </ci> <ci> KmP1 </ci> </apply> <apply> <power/> <apply> <divide/> <ci> P1 </ci> <ci> KmP1 </ci> </apply> <cn> 2 </cn> </apply> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition metaid="COPASI55" id="function_5" name="CK 3S 2P 1I GAPDH"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI55"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-08-30T16:38:24Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <math xmlns="http://www.w3.org/1998/Math/MathML"> <lambda> <bvar> <ci> KmI </ci> </bvar> <bvar> <ci> I </ci> </bvar> <bvar> <ci> Vmax </ci> </bvar> <bvar> <ci> S1 </ci> </bvar> <bvar> <ci> KmS1 </ci> </bvar> <bvar> <ci> S2 </ci> </bvar> <bvar> <ci> KmS2 </ci> </bvar> <bvar> <ci> S3 </ci> </bvar> <bvar> <ci> KmS3 </ci> </bvar> <bvar> <ci> Keq </ci> </bvar> <bvar> <ci> KmP1 </ci> </bvar> <bvar> <ci> KmP2 </ci> </bvar> <bvar> <ci> P1 </ci> </bvar> <bvar> <ci> P2 </ci> </bvar> <apply> <times/> <apply> <divide/> <ci> KmI </ci> <apply> <plus/> <ci> KmI </ci> <ci> I </ci> </apply> </apply> <apply> <divide/> <apply> <minus/> <apply> <times/> <ci> Vmax </ci> <apply> <divide/> <ci> S1 </ci> <ci> KmS1 </ci> </apply> <apply> <divide/> <ci> S2 </ci> <ci> KmS2 </ci> </apply> <apply> <divide/> <ci> S3 </ci> <ci> KmS3 </ci> </apply> </apply> <apply> <times/> <apply> <divide/> <ci> Vmax </ci> <ci> Keq </ci> </apply> <apply> <divide/> <apply> <times/> <ci> KmP1 </ci> <ci> KmP2 </ci> </apply> <apply> <times/> <ci> KmS1 </ci> <ci> KmS2 </ci> <ci> KmS3 </ci> </apply> </apply> <apply> <divide/> <ci> P1 </ci> <ci> KmP1 </ci> </apply> <apply> <divide/> <ci> P2 </ci> <ci> KmP2 </ci> </apply> </apply> </apply> <apply> <minus/> <apply> <plus/> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S1 </ci> <ci> KmS1 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S2 </ci> <ci> KmS2 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S3 </ci> <ci> KmS3 </ci> </apply> </apply> </apply> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P1 </ci> <ci> KmP1 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P2 </ci> <ci> KmP2 </ci> </apply> </apply> </apply> </apply> <cn> 1 </cn> </apply> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition metaid="COPASI56" id="function_8" name="CK 2S 2P 2A 1I LDH"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI56"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-08-30T16:39:49Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <math xmlns="http://www.w3.org/1998/Math/MathML"> <lambda> <bvar> <ci> A1 </ci> </bvar> <bvar> <ci> KmA1 </ci> </bvar> <bvar> <ci> A2 </ci> </bvar> <bvar> <ci> KmA2 </ci> </bvar> <bvar> <ci> KmI </ci> </bvar> <bvar> <ci> I </ci> </bvar> <bvar> <ci> Vmax </ci> </bvar> <bvar> <ci> S1 </ci> </bvar> <bvar> <ci> KmS1 </ci> </bvar> <bvar> <ci> S2 </ci> </bvar> <bvar> <ci> KmS2 </ci> </bvar> <bvar> <ci> Keq </ci> </bvar> <bvar> <ci> KmP1 </ci> </bvar> <bvar> <ci> KmP2 </ci> </bvar> <bvar> <ci> P1 </ci> </bvar> <bvar> <ci> P2 </ci> </bvar> <apply> <times/> <apply> <divide/> <ci> A1 </ci> <apply> <plus/> <ci> KmA1 </ci> <ci> A1 </ci> </apply> </apply> <apply> <divide/> <ci> A2 </ci> <apply> <plus/> <ci> KmA2 </ci> <ci> A2 </ci> </apply> </apply> <apply> <divide/> <apply> <times/> <apply> <divide/> <ci> KmI </ci> <apply> <plus/> <ci> KmI </ci> <ci> I </ci> </apply> </apply> <apply> <minus/> <apply> <times/> <ci> Vmax </ci> <apply> <divide/> <ci> S1 </ci> <ci> KmS1 </ci> </apply> <apply> <divide/> <ci> S2 </ci> <ci> KmS2 </ci> </apply> </apply> <apply> <times/> <apply> <divide/> <ci> Vmax </ci> <ci> Keq </ci> </apply> <apply> <divide/> <apply> <times/> <ci> KmP1 </ci> <ci> KmP2 </ci> </apply> <apply> <times/> <ci> KmS1 </ci> <ci> KmS2 </ci> </apply> </apply> <apply> <divide/> <ci> P1 </ci> <ci> KmP1 </ci> </apply> <apply> <divide/> <ci> P2 </ci> <ci> KmP2 </ci> </apply> </apply> </apply> </apply> <apply> <minus/> <apply> <plus/> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S1 </ci> <ci> KmS1 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S2 </ci> <ci> KmS2 </ci> </apply> </apply> </apply> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P1 </ci> <ci> KmP1 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P2 </ci> <ci> KmP2 </ci> </apply> </apply> </apply> </apply> <cn> 1 </cn> </apply> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition metaid="COPASI57" id="function_9" name="CK 2S 2P 1I PFL"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI57"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-08-30T16:41:10Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <math xmlns="http://www.w3.org/1998/Math/MathML"> <lambda> <bvar> <ci> KmI </ci> </bvar> <bvar> <ci> I </ci> </bvar> <bvar> <ci> Vmax </ci> </bvar> <bvar> <ci> S1 </ci> </bvar> <bvar> <ci> KmS1 </ci> </bvar> <bvar> <ci> S2 </ci> </bvar> <bvar> <ci> KmS2 </ci> </bvar> <bvar> <ci> Keq </ci> </bvar> <bvar> <ci> KmP1 </ci> </bvar> <bvar> <ci> KmP2 </ci> </bvar> <bvar> <ci> P1 </ci> </bvar> <bvar> <ci> P2 </ci> </bvar> <apply> <times/> <apply> <divide/> <ci> KmI </ci> <apply> <plus/> <ci> I </ci> <ci> KmI </ci> </apply> </apply> <apply> <divide/> <apply> <minus/> <apply> <times/> <ci> Vmax </ci> <apply> <divide/> <ci> S1 </ci> <ci> KmS1 </ci> </apply> <apply> <divide/> <ci> S2 </ci> <ci> KmS2 </ci> </apply> </apply> <apply> <times/> <apply> <divide/> <ci> Vmax </ci> <ci> Keq </ci> </apply> <apply> <divide/> <apply> <times/> <ci> KmP1 </ci> <ci> KmP2 </ci> </apply> <apply> <times/> <ci> KmS1 </ci> <ci> KmS2 </ci> </apply> </apply> <apply> <divide/> <ci> P1 </ci> <ci> KmP1 </ci> </apply> <apply> <divide/> <ci> P2 </ci> <ci> KmP2 </ci> </apply> </apply> </apply> <apply> <minus/> <apply> <plus/> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S1 </ci> <ci> KmS1 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S2 </ci> <ci> KmS2 </ci> </apply> </apply> </apply> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P1 </ci> <ci> KmP1 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P2 </ci> <ci> KmP2 </ci> </apply> </apply> </apply> </apply> <cn> 1 </cn> </apply> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition metaid="COPASI58" id="function_7" name="CK 2S 2P 1A 1I PYK"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI58"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-08-30T16:42:28Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <math xmlns="http://www.w3.org/1998/Math/MathML"> <lambda> <bvar> <ci> KmI </ci> </bvar> <bvar> <ci> I </ci> </bvar> <bvar> <ci> A </ci> </bvar> <bvar> <ci> KmA </ci> </bvar> <bvar> <ci> Vmax </ci> </bvar> <bvar> <ci> S1 </ci> </bvar> <bvar> <ci> KmS1 </ci> </bvar> <bvar> <ci> S2 </ci> </bvar> <bvar> <ci> KmS2 </ci> </bvar> <bvar> <ci> Keq </ci> </bvar> <bvar> <ci> KmP1 </ci> </bvar> <bvar> <ci> KmP2 </ci> </bvar> <bvar> <ci> P1 </ci> </bvar> <bvar> <ci> P2 </ci> </bvar> <apply> <times/> <apply> <divide/> <ci> KmI </ci> <apply> <plus/> <ci> KmI </ci> <ci> I </ci> </apply> </apply> <apply> <divide/> <ci> A </ci> <apply> <plus/> <ci> KmA </ci> <ci> A </ci> </apply> </apply> <apply> <divide/> <apply> <minus/> <apply> <times/> <ci> Vmax </ci> <apply> <divide/> <ci> S1 </ci> <ci> KmS1 </ci> </apply> <apply> <divide/> <ci> S2 </ci> <ci> KmS2 </ci> </apply> </apply> <apply> <times/> <apply> <divide/> <ci> Vmax </ci> <ci> Keq </ci> </apply> <apply> <divide/> <apply> <times/> <ci> KmP1 </ci> <ci> KmP2 </ci> </apply> <apply> <times/> <ci> KmS1 </ci> <ci> KmS2 </ci> </apply> </apply> <apply> <divide/> <ci> P1 </ci> <ci> KmP1 </ci> </apply> <apply> <divide/> <ci> P2 </ci> <ci> KmP2 </ci> </apply> </apply> </apply> <apply> <minus/> <apply> <plus/> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S1 </ci> <ci> KmS1 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> S2 </ci> <ci> KmS2 </ci> </apply> </apply> </apply> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P1 </ci> <ci> KmP1 </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P2 </ci> <ci> KmP2 </ci> </apply> </apply> </apply> </apply> <cn> 1 </cn> </apply> </apply> </apply> </lambda> </math> </functionDefinition> </listOfFunctionDefinitions> <listOfUnitDefinitions> <unitDefinition id="substance" name="substance"> <listOfUnits> <unit kind="mole" scale="-3"/> </listOfUnits> </unitDefinition> </listOfUnitDefinitions> <listOfCompartments> <compartment id="compartment_1" name="Intracellular" size="0.01567"/> <compartment metaid="COPASI2" id="compartment_2" name="Extracellular" size="1"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI2"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-08-03T10:50:11Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </compartment> </listOfCompartments> <listOfSpecies> <species metaid="COPASI3" id="species_1" name="G6P" compartment="compartment_1" initialConcentration="0.0718881703463247"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI3"> <dcterms:created> <rdf:Description> 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xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#COPASI17"> <bqbiol:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:obo.chebi:17234"/> </rdf:Bag> </bqbiol:is> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="COPASI18" id="species_16" name="HPr-ser-P" compartment="compartment_1" initialConcentration="0"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI18"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-08-30T16:47:46Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </species> <species metaid="COPASI19" id="species_17" name="HPr" compartment="compartment_1" initialConcentration="0.1599999922951"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI19"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-08-30T16:47:45Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </species> <species metaid="COPASI20" id="species_18" name="nadp" compartment="compartment_1" initialConcentration="4.55143591757997"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI20"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-11-08T14:21:35Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> <CopasiMT:is rdf:resource="urn:miriam:obo.chebi:18009"/> </rdf:Description> </rdf:RDF> </COPASI> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#COPASI20"> <bqbiol:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:obo.chebi:18009"/> </rdf:Bag> </bqbiol:is> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="COPASI21" id="species_19" name="nadph" compartment="compartment_1" initialConcentration="0"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI21"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-11-08T14:21:38Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> <CopasiMT:is rdf:resource="urn:miriam:obo.chebi:16474"/> </rdf:Description> </rdf:RDF> </COPASI> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#COPASI21"> <bqbiol:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:obo.chebi:16474"/> </rdf:Bag> </bqbiol:is> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="COPASI22" id="species_20" name="glucose extra" compartment="compartment_2" initialConcentration="8.19196275198244"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI22"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-08-30T16:45:25Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> <CopasiMT:is rdf:resource="urn:miriam:obo.chebi:17234"/> </rdf:Description> </rdf:RDF> </COPASI> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#COPASI22"> <bqbiol:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:obo.chebi:17234"/> </rdf:Bag> </bqbiol:is> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="COPASI23" id="species_21" name="lactate_ex" compartment="compartment_2" initialConcentration="1.99999990368875"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI23"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-11-08T14:21:32Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> <CopasiMT:is rdf:resource="urn:miriam:obo.chebi:24996"/> </rdf:Description> </rdf:RDF> </COPASI> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#COPASI23"> <bqbiol:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:obo.chebi:24996"/> </rdf:Bag> </bqbiol:is> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="COPASI24" id="species_22" name="Pi extra" compartment="compartment_2" initialConcentration="0"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI24"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-08-30T16:47:29Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> <CopasiMT:is rdf:resource="urn:miriam:obo.chebi:18367"/> </rdf:Description> </rdf:RDF> </COPASI> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#COPASI24"> <bqbiol:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:obo.chebi:18367"/> </rdf:Bag> </bqbiol:is> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="COPASI25" id="species_23" name="formate" compartment="compartment_2" initialConcentration="0"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI25"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-11-08T14:15:28Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> <CopasiMT:is rdf:resource="urn:miriam:obo.chebi:30751"/> </rdf:Description> </rdf:RDF> </COPASI> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#COPASI25"> <bqbiol:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:obo.chebi:30751"/> </rdf:Bag> </bqbiol:is> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="COPASI26" id="species_24" name="ethanol" compartment="compartment_2" initialConcentration="0"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI26"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-08-30T16:47:42Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> <CopasiMT:is rdf:resource="urn:miriam:obo.chebi:16236"/> </rdf:Description> </rdf:RDF> </COPASI> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#COPASI26"> <bqbiol:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:obo.chebi:16236"/> </rdf:Bag> </bqbiol:is> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="COPASI27" id="species_25" name="acetate" compartment="compartment_2" initialConcentration="1"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI27"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-04-13T10:13:52Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> <CopasiMT:is rdf:resource="urn:miriam:obo.chebi:30089"/> </rdf:Description> </rdf:RDF> </COPASI> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#COPASI27"> <bqbiol:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:obo.chebi:30089"/> </rdf:Bag> </bqbiol:is> </rdf:Description> </rdf:RDF> </annotation> </species> </listOfSpecies> <listOfParameters> <parameter metaid="COPASI28" id="parameter_1" name="ATP_ADP_sum" value="5"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI28"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-02-16T10:40:53Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> </listOfParameters> <listOfInitialAssignments> <initialAssignment symbol="species_9"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <minus/> <ci> parameter_1 </ci> <ci> species_10 </ci> </apply> </math> </initialAssignment> </listOfInitialAssignments> <listOfReactions> <reaction metaid="COPASI29" id="reaction_1" name="pts" reversible="false"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI29"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-01-10T09:14:14Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfReactants> <speciesReference species="species_17"/> <speciesReference species="species_5"/> <speciesReference species="species_20"/> </listOfReactants> <listOfProducts> <speciesReference species="species_17"/> <speciesReference species="species_6"/> <speciesReference species="species_1"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <ci> function_1 </ci> <ci> Vmax </ci> <ci> species_17 </ci> <ci> KmS1 </ci> <ci> species_5 </ci> <ci> KmS2 </ci> <ci> species_20 </ci> <ci> KmS3 </ci> <ci> species_17 </ci> <ci> KmP1 </ci> <ci> species_6 </ci> <ci> KmP2 </ci> <ci> species_1 </ci> <ci> KmP3 </ci> </apply> </math> <listOfParameters> <parameter id="Vmax" name="Vmax" value="48.5535"/> <parameter id="KmS1" name="KmS1" value="69.6334"/> <parameter id="KmS2" name="KmS2" value="0.593492"/> <parameter id="KmS3" name="KmS3" value="0.000711129"/> <parameter id="KmP1" name="KmP1" value="0.0103466"/> <parameter id="KmP2" name="KmP2" value="82.4459"/> <parameter id="KmP3" name="KmP3" value="0.01"/> </listOfParameters> </kineticLaw> </reaction> <reaction metaid="COPASI30" id="reaction_2" name="pfk" reversible="false"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI30"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-01-10T09:17:54Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> <CopasiMT:is rdf:resource="urn:miriam:kegg.genes:K00850"/> </rdf:Description> </rdf:RDF> </COPASI> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#COPASI30"> <bqbiol:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:kegg.genes:K00850"/> </rdf:Bag> </bqbiol:is> </rdf:Description> </rdf:RDF> </annotation> <listOfReactants> <speciesReference species="species_1"/> <speciesReference species="species_10"/> </listOfReactants> <listOfProducts> <speciesReference species="species_2"/> <speciesReference species="species_9"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> function_2 </ci> <ci> species_1 </ci> <ci> KmS1 </ci> <ci> species_10 </ci> <ci> KmS2 </ci> <ci> species_2 </ci> <ci> KmP1 </ci> <ci> species_9 </ci> <ci> KmP2 </ci> <ci> Vmax </ci> </apply> </apply> </math> <listOfParameters> <parameter id="KmS1" name="KmS1" value="4.75723"/> <parameter id="KmS2" name="KmS2" value="0.299797"/> <parameter id="KmP1" name="KmP1" value="21.3025"/> <parameter id="KmP2" name="KmP2" value="0.429715"/> <parameter id="Vmax" name="Vmax" value="8.45855"/> </listOfParameters> </kineticLaw> </reaction> <reaction metaid="COPASI31" id="reaction_3" name="fba"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI31"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-01-10T09:18:54Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> <CopasiMT:is rdf:resource="urn:miriam:kegg.genes:K01624"/> </rdf:Description> </rdf:RDF> </COPASI> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#COPASI31"> <bqbiol:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:kegg.genes:K01624"/> </rdf:Bag> </bqbiol:is> </rdf:Description> </rdf:RDF> </annotation> <listOfReactants> <speciesReference species="species_2"/> </listOfReactants> <listOfProducts> <speciesReference species="species_3" stoichiometry="2"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> function_3 </ci> <ci> Vmax </ci> <ci> species_2 </ci> <ci> KmS1 </ci> <ci> Keq </ci> <ci> KmP1 </ci> <ci> species_3 </ci> <ci> species_3 </ci> </apply> </apply> </math> <listOfParameters> <parameter id="Vmax" name="Vmax" value="627.32"/> <parameter id="KmS1" name="KmS1" value="10.9855"/> <parameter id="Keq" name="Keq" value="0.056"/> <parameter id="KmP1" name="KmP1" value="17.99"/> </listOfParameters> </kineticLaw> </reaction> <reaction metaid="COPASI32" id="reaction_4" name="PaseII" reversible="false"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI32"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-01-10T09:18:37Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfReactants> <speciesReference species="species_1"/> </listOfReactants> <listOfProducts> <speciesReference species="species_15"/> <speciesReference species="species_8"/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species="species_16"/> </listOfModifiers> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> function_4 </ci> <ci> species_1 </ci> <ci> KmS </ci> <ci> species_15 </ci> <ci> KmP1 </ci> <ci> species_8 </ci> <ci> KmP2 </ci> <ci> species_16 </ci> <ci> KmA </ci> <ci> Vmax </ci> </apply> </apply> </math> <listOfParameters> <parameter id="KmS" name="KmS" value="1.52417"/> <parameter id="KmP1" name="KmP1" value="9.51281"/> <parameter id="KmP2" name="KmP2" value="96.2342"/> <parameter id="KmA" name="KmA" value="0.0254012"/> <parameter id="Vmax" name="Vmax" value="0.948695"/> </listOfParameters> </kineticLaw> </reaction> <reaction metaid="COPASI33" id="reaction_5" name="gapdh"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI33"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-01-10T09:19:00Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> <CopasiMT:is rdf:resource="urn:miriam:kegg.genes:K00134"/> </rdf:Description> </rdf:RDF> </COPASI> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#COPASI33"> <bqbiol:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:kegg.genes:K00134"/> </rdf:Bag> </bqbiol:is> </rdf:Description> </rdf:RDF> </annotation> <listOfReactants> <speciesReference species="species_3"/> <speciesReference species="species_11"/> <speciesReference species="species_8"/> </listOfReactants> <listOfProducts> <speciesReference species="species_4"/> <speciesReference species="species_12"/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species="species_12"/> </listOfModifiers> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> function_5 </ci> <ci> KmI </ci> <ci> species_12 </ci> <ci> Vmax </ci> <ci> species_3 </ci> <ci> KmS1 </ci> <ci> species_11 </ci> <ci> KmS2 </ci> <ci> species_8 </ci> <ci> KmS3 </ci> <ci> Keq </ci> <ci> KmP1 </ci> <ci> KmP2 </ci> <ci> species_4 </ci> <ci> species_12 </ci> </apply> </apply> </math> <listOfParameters> <parameter id="KmI" name="KmI" value="59.7128"/> <parameter id="Vmax" name="Vmax" value="17.9567"/> <parameter id="KmS1" name="KmS1" value="4.00345"/> <parameter id="KmS2" name="KmS2" value="1.56582"/> <parameter id="KmS3" name="KmS3" value="0.438029"/> <parameter id="Keq" name="Keq" value="0.0007"/> <parameter id="KmP1" name="KmP1" value="0.279505"/> <parameter id="KmP2" name="KmP2" value="0.133646"/> </listOfParameters> </kineticLaw> </reaction> <reaction metaid="COPASI34" id="reaction_6" name="eno"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI34"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-01-10T09:19:24Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> <CopasiMT:is rdf:resource="urn:miriam:kegg.genes:K01689"/> </rdf:Description> </rdf:RDF> </COPASI> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#COPASI34"> <bqbiol:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:kegg.genes:K01689"/> </rdf:Bag> </bqbiol:is> </rdf:Description> </rdf:RDF> </annotation> <listOfReactants> <speciesReference species="species_4"/> <speciesReference species="species_9"/> </listOfReactants> <listOfProducts> <speciesReference species="species_5"/> <speciesReference species="species_10"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> function_6 </ci> <ci> Vmax </ci> <ci> species_4 </ci> <ci> KmS1 </ci> <ci> species_9 </ci> <ci> KmS2 </ci> <ci> Keq </ci> <ci> KmP1 </ci> <ci> KmP2 </ci> <ci> species_5 </ci> <ci> species_10 </ci> </apply> </apply> </math> <listOfParameters> <parameter id="Vmax" name="Vmax" value="21.7206"/> <parameter id="KmS1" name="KmS1" value="0.670465"/> <parameter id="KmS2" name="KmS2" value="0.0332309"/> <parameter id="Keq" name="Keq" value="27.55"/> <parameter id="KmP1" name="KmP1" value="5.11386"/> <parameter id="KmP2" name="KmP2" value="2.81202"/> </listOfParameters> </kineticLaw> </reaction> <reaction metaid="COPASI35" id="reaction_7" name="pyk"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI35"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-01-10T09:20:02Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> <CopasiMT:is rdf:resource="urn:miriam:kegg.genes:K00873"/> </rdf:Description> </rdf:RDF> </COPASI> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#COPASI35"> <bqbiol:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:kegg.genes:K00873"/> </rdf:Bag> </bqbiol:is> </rdf:Description> </rdf:RDF> </annotation> <listOfReactants> <speciesReference species="species_5"/> <speciesReference species="species_9"/> </listOfReactants> <listOfProducts> <speciesReference species="species_6"/> <speciesReference species="species_10"/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species="species_8"/> <modifierSpeciesReference species="species_1"/> </listOfModifiers> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> function_7 </ci> <ci> KmI </ci> <ci> species_8 </ci> <ci> species_1 </ci> <ci> KmA </ci> <ci> Vmax </ci> <ci> species_5 </ci> <ci> KmS1 </ci> <ci> species_9 </ci> <ci> KmS2 </ci> <ci> Keq </ci> <ci> KmP1 </ci> <ci> KmP2 </ci> <ci> species_6 </ci> <ci> species_10 </ci> </apply> </apply> </math> <listOfParameters> <parameter id="KmI" name="KmI" value="58.7337"/> <parameter id="KmA" name="KmA" value="8.58968"/> <parameter id="Vmax" name="Vmax" value="49.3587"/> <parameter id="KmS1" name="KmS1" value="6.72317"/> <parameter id="KmS2" name="KmS2" value="2.28978"/> <parameter id="Keq" name="Keq" value="6500"/> <parameter id="KmP1" name="KmP1" value="6.56443"/> <parameter id="KmP2" name="KmP2" value="33.5038"/> </listOfParameters> </kineticLaw> </reaction> <reaction metaid="COPASI36" id="reaction_8" name="ldh"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI36"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-01-10T09:20:41Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> <CopasiMT:hasPart> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:kegg.genes:K00016"/> <rdf:li rdf:resource="urn:miriam:kegg.genes:K003778"/> </rdf:Bag> </CopasiMT:hasPart> </rdf:Description> </rdf:RDF> </COPASI> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#COPASI36"> <bqbiol:hasPart> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:kegg.genes:K003778"/> </rdf:Bag> </bqbiol:hasPart> <bqbiol:hasPart> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:kegg.genes:K00016"/> </rdf:Bag> </bqbiol:hasPart> </rdf:Description> </rdf:RDF> </annotation> <listOfReactants> <speciesReference species="species_6"/> <speciesReference species="species_12"/> </listOfReactants> <listOfProducts> <speciesReference species="species_14"/> <speciesReference species="species_11"/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species="species_2"/> <modifierSpeciesReference species="species_8"/> <modifierSpeciesReference species="species_11"/> </listOfModifiers> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> function_8 </ci> <ci> species_2 </ci> <ci> KmA1 </ci> <ci> species_8 </ci> <ci> KmA2 </ci> <ci> KmI </ci> <ci> species_11 </ci> <ci> Vmax </ci> <ci> species_6 </ci> <ci> KmS1 </ci> <ci> species_12 </ci> <ci> KmS2 </ci> <ci> Keq </ci> <ci> KmP1 </ci> <ci> KmP2 </ci> <ci> species_14 </ci> <ci> species_11 </ci> </apply> </apply> </math> <listOfParameters> <parameter id="KmA1" name="KmA1" value="2.08854"/> <parameter id="KmA2" name="KmA2" value="0.0622563"/> <parameter id="KmI" name="KmI" value="5.2236"/> <parameter id="Vmax" name="Vmax" value="23.9471"/> <parameter id="KmS1" name="KmS1" value="0.132532"/> <parameter id="KmS2" name="KmS2" value="0.00621337"/> <parameter id="Keq" name="Keq" value="360000"/> <parameter id="KmP1" name="KmP1" value="15.4053"/> <parameter id="KmP2" name="KmP2" value="1.47089"/> </listOfParameters> </kineticLaw> </reaction> <reaction metaid="COPASI37" id="reaction_9" name="pfl"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI37"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-01-10T09:21:32Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> <CopasiMT:is rdf:resource="urn:miriam:kegg.genes:K00656"/> </rdf:Description> </rdf:RDF> </COPASI> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#COPASI37"> <bqbiol:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:kegg.genes:K00656"/> </rdf:Bag> </bqbiol:is> </rdf:Description> </rdf:RDF> </annotation> <listOfReactants> <speciesReference species="species_6"/> <speciesReference species="species_13"/> </listOfReactants> <listOfProducts> <speciesReference species="species_7"/> <speciesReference species="species_23"/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species="species_3"/> </listOfModifiers> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <ci> function_9 </ci> <ci> KmI </ci> <ci> species_3 </ci> <ci> Vmax </ci> <ci> species_6 </ci> <ci> KmS1 </ci> <ci> species_13 </ci> <ci> KmS2 </ci> <ci> Keq </ci> <ci> KmP1 </ci> <ci> KmP2 </ci> <ci> species_7 </ci> <ci> species_23 </ci> </apply> </math> <listOfParameters> <parameter id="KmI" name="KmI" value="2.66561"/> <parameter id="Vmax" name="Vmax" value="28.1293"/> <parameter id="KmS1" name="KmS1" value="25.653"/> <parameter id="KmS2" name="KmS2" value="0.00391879"/> <parameter id="Keq" name="Keq" value="650"/> <parameter id="KmP1" name="KmP1" value="0.484717"/> <parameter id="KmP2" name="KmP2" value="73.6319"/> </listOfParameters> </kineticLaw> </reaction> <reaction metaid="COPASI38" id="reaction_10" name="ack" reversible="false"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI38"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-01-10T09:21:42Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> <CopasiMT:hasPart rdf:resource="urn:miriam:kegg.genes:K04072"/> </rdf:Description> </rdf:RDF> </COPASI> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#COPASI38"> <bqbiol:hasPart> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:kegg.genes:K04072"/> </rdf:Bag> </bqbiol:hasPart> </rdf:Description> </rdf:RDF> </annotation> <listOfReactants> <speciesReference species="species_7"/> <speciesReference species="species_8"/> <speciesReference species="species_9"/> </listOfReactants> <listOfProducts> <speciesReference species="species_25"/> <speciesReference species="species_13"/> <speciesReference species="species_10"/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species="species_2"/> </listOfModifiers> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <ci> function_10 </ci> <ci> KmI </ci> <ci> species_2 </ci> <ci> Vmax </ci> <ci> species_7 </ci> <ci> KmS1 </ci> <ci> species_8 </ci> <ci> KmS2 </ci> <ci> species_9 </ci> <ci> KmS3 </ci> <ci> species_25 </ci> <ci> KmP1 </ci> <ci> species_13 </ci> <ci> KmP2 </ci> <ci> species_10 </ci> <ci> kmP3 </ci> </apply> </math> <listOfParameters> <parameter id="KmI" name="KmI" value="95.9885"/> <parameter id="Vmax" name="Vmax" value="23.6651"/> <parameter id="KmS1" name="KmS1" value="0.55578"/> <parameter id="KmS2" name="KmS2" value="0.717283"/> <parameter id="KmS3" name="KmS3" value="0.863311"/> <parameter id="KmP1" name="KmP1" value="0.800708"/> <parameter id="KmP2" name="KmP2" value="0.0436744"/> <parameter id="kmP3" name="kmP3" value="21.8726"/> </listOfParameters> </kineticLaw> </reaction> <reaction metaid="COPASI39" id="reaction_11" name="adh" reversible="false"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI39"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-01-10T09:21:51Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> <CopasiMT:hasPart rdf:resource="urn:miriam:kegg.genes:K00001"/> </rdf:Description> </rdf:RDF> </COPASI> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#COPASI39"> <bqbiol:hasPart> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:kegg.genes:K00001"/> </rdf:Bag> </bqbiol:hasPart> </rdf:Description> </rdf:RDF> </annotation> <listOfReactants> <speciesReference species="species_7"/> <speciesReference species="species_12" stoichiometry="2"/> </listOfReactants> <listOfProducts> <speciesReference species="species_24"/> <speciesReference species="species_11" stoichiometry="2"/> <speciesReference species="species_13"/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species="species_10"/> </listOfModifiers> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <ci> function_11 </ci> <ci> KmI </ci> <ci> species_10 </ci> <ci> Vmax </ci> <ci> species_7 </ci> <ci> KmS1 </ci> <ci> species_12 </ci> <ci> KmS2 </ci> <ci> species_12 </ci> <ci> species_24 </ci> <ci> KmP1 </ci> <ci> species_11 </ci> <ci> KmP2 </ci> <ci> species_13 </ci> <ci> KmP4 </ci> </apply> </math> <listOfParameters> <parameter id="KmI" name="KmI" value="99.9461"/> <parameter id="Vmax" name="Vmax" value="58.8517"/> <parameter id="KmS1" name="KmS1" value="0.000745245"/> <parameter id="KmS2" name="KmS2" value="0.0202223"/> <parameter id="KmP1" name="KmP1" value="3.31391"/> <parameter id="KmP2" name="KmP2" value="0.0114074"/> <parameter id="KmP4" name="KmP4" value="0.0795358"/> </listOfParameters> </kineticLaw> </reaction> <reaction metaid="COPASI40" id="reaction_12" name="atpase" reversible="false"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI40"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-02-21T16:29:48Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfReactants> <speciesReference species="species_10"/> </listOfReactants> <listOfProducts> <speciesReference species="species_9"/> <speciesReference species="species_8"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> function_12 </ci> <ci> species_10 </ci> <ci> Shalve </ci> <ci> V </ci> <ci> h </ci> </apply> </apply> </math> <listOfParameters> <parameter id="Shalve" name="Shalve" value="8.15371"/> <parameter id="V" name="V" value="60.5877"/> <parameter id="h" name="h" value="3"/> </listOfParameters> </kineticLaw> </reaction> <reaction metaid="COPASI41" id="reaction_13" name="Pi transport"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI41"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2010-11-17T15:34:06Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfReactants> <speciesReference species="species_22"/> </listOfReactants> <listOfProducts> <speciesReference species="species_8"/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species="species_10"/> <modifierSpeciesReference species="species_22"/> </listOfModifiers> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <ci> function_13 </ci> <ci> KmI </ci> <ci> species_10 </ci> <ci> species_22 </ci> <ci> KmA </ci> <ci> Vmax </ci> <ci> species_22 </ci> <ci> species_8 </ci> <ci> KmS </ci> <ci> KmP </ci> </apply> </math> <listOfParameters> <parameter id="KmI" name="KmI" value="16.289"/> <parameter id="KmA" name="KmA" value="80.4333"/> <parameter id="Vmax" name="Vmax" value="0.252356"/> <parameter id="KmS" name="KmS" value="6.84057"/> <parameter id="KmP" name="KmP" value="0.500353"/> </listOfParameters> </kineticLaw> </reaction> <reaction metaid="COPASI42" id="reaction_14" name="gk" reversible="false"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI42"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-01-10T09:17:39Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> <CopasiMT:is rdf:resource="urn:miriam:kegg.genes:K00845"/> </rdf:Description> </rdf:RDF> </COPASI> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#COPASI42"> <bqbiol:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:kegg.genes:K00845"/> </rdf:Bag> </bqbiol:is> </rdf:Description> </rdf:RDF> </annotation> <listOfReactants> <speciesReference species="species_15"/> <speciesReference species="species_10"/> </listOfReactants> <listOfProducts> <speciesReference species="species_1"/> <speciesReference species="species_9"/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species="species_1"/> <modifierSpeciesReference species="species_9"/> </listOfModifiers> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> function_14 </ci> <ci> KmI1 </ci> <ci> species_1 </ci> <ci> KmI2 </ci> <ci> species_9 </ci> <ci> Vmax </ci> <ci> species_15 </ci> <ci> KmS1 </ci> <ci> species_10 </ci> <ci> KmS2 </ci> <ci> species_1 </ci> <ci> KmP1 </ci> <ci> species_9 </ci> <ci> KmP2 </ci> </apply> </apply> </math> <listOfParameters> <parameter id="KmI1" name="KmI1" value="96.5655"/> <parameter id="KmI2" name="KmI2" value="29.2956"/> <parameter id="Vmax" name="Vmax" value="42.6111"/> <parameter id="KmS1" name="KmS1" value="6.09834"/> <parameter id="KmS2" name="KmS2" value="1.97174"/> <parameter id="KmP1" name="KmP1" value="0.0100032"/> <parameter id="KmP2" name="KmP2" value="0.01"/> </listOfParameters> </kineticLaw> </reaction> <reaction metaid="COPASI43" id="reaction_15" name="lac transporter" reversible="false"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI43"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-01-10T09:21:20Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfReactants> <speciesReference species="species_14"/> </listOfReactants> <listOfProducts> <speciesReference species="species_21"/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species="species_6"/> </listOfModifiers> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <ci> function_15 </ci> <ci> KmI </ci> <ci> species_6 </ci> <ci> Vmax </ci> <ci> species_14 </ci> <ci> KmS </ci> <ci> species_21 </ci> <ci> KmP </ci> </apply> </math> <listOfParameters> <parameter id="KmI" name="KmI" value="3.7222"/> <parameter id="Vmax" name="Vmax" value="957.681"/> <parameter id="KmS" name="KmS" value="6.1841"/> <parameter id="KmP" name="KmP" value="1.84584"/> </listOfParameters> </kineticLaw> </reaction> <reaction metaid="COPASI44" id="reaction_16" name="glc permease"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI44"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-02-21T16:26:09Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfReactants> <speciesReference species="species_20"/> </listOfReactants> <listOfProducts> <speciesReference species="species_15"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <ci> diffusion </ci> <ci> k </ci> <ci> species_20 </ci> <ci> species_15 </ci> </apply> </math> <listOfParameters> <parameter id="k" name="k" value="0.00013213"/> </listOfParameters> </kineticLaw> </reaction> <reaction metaid="COPASI45" id="reaction_17" name="HPr kinase" reversible="false"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI45"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-01-10T09:17:12Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfReactants> <speciesReference species="species_17"/> <speciesReference species="species_10"/> </listOfReactants> <listOfProducts> <speciesReference species="species_16"/> <speciesReference species="species_9"/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species="species_8"/> <modifierSpeciesReference species="species_2"/> </listOfModifiers> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> function_16 </ci> <ci> species_17 </ci> <ci> KmS1 </ci> <ci> species_10 </ci> <ci> KmS2 </ci> <ci> species_16 </ci> <ci> KmP1 </ci> <ci> species_9 </ci> <ci> KmP2 </ci> <ci> KmI </ci> <ci> species_8 </ci> <ci> species_2 </ci> <ci> KmA </ci> <ci> Vmax </ci> </apply> </apply> </math> <listOfParameters> <parameter id="KmS1" name="KmS1" value="0.198387"/> <parameter id="KmS2" name="KmS2" value="0.320338"/> <parameter id="KmP1" name="KmP1" value="16.205"/> <parameter id="KmP2" name="KmP2" value="0.765287"/> <parameter id="KmI" name="KmI" value="2.79646"/> <parameter id="KmA" name="KmA" value="12.1241"/> <parameter id="Vmax" name="Vmax" value="75.6"/> </listOfParameters> </kineticLaw> </reaction> <reaction metaid="COPASI46" id="reaction_18" name="HPr phosphatase" reversible="false"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI46"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-01-10T09:16:26Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfReactants> <speciesReference species="species_16"/> </listOfReactants> <listOfProducts> <speciesReference species="species_17"/> <speciesReference species="species_8"/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species="species_10"/> <modifierSpeciesReference species="species_8"/> </listOfModifiers> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> function_17 </ci> <ci> KmI </ci> <ci> species_10 </ci> <ci> species_8 </ci> <ci> KmA </ci> <ci> Vmax </ci> <ci> species_16 </ci> <ci> KmS </ci> <ci> species_17 </ci> <ci> KmP1 </ci> <ci> species_8 </ci> <ci> KmP2 </ci> </apply> </apply> </math> <listOfParameters> <parameter id="KmI" name="KmI" value="5.86785"/> <parameter id="KmA" name="KmA" value="0.13512"/> <parameter id="Vmax" name="Vmax" value="121.581"/> <parameter id="KmS" name="KmS" value="8.06926"/> <parameter id="KmP1" name="KmP1" value="17.3915"/> <parameter id="KmP2" name="KmP2" value="9.5632"/> </listOfParameters> </kineticLaw> </reaction> <reaction metaid="COPASI47" id="reaction_19" name="gapn" reversible="false"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI47"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-01-10T09:19:13Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfReactants> <speciesReference species="species_3"/> <speciesReference species="species_18"/> </listOfReactants> <listOfProducts> <speciesReference species="species_5"/> <speciesReference species="species_19"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> function_2 </ci> <ci> species_3 </ci> <ci> KmS1 </ci> <ci> species_18 </ci> <ci> KmS2 </ci> <ci> species_5 </ci> <ci> KmP1 </ci> <ci> species_19 </ci> <ci> KmP2 </ci> <ci> Vmax </ci> </apply> </apply> </math> <listOfParameters> <parameter id="KmS1" name="KmS1" value="4.27491"/> <parameter id="KmS2" name="KmS2" value="0.039067"/> <parameter id="KmP1" name="KmP1" value="4.92954"/> <parameter id="KmP2" name="KmP2" value="98.9729"/> <parameter id="Vmax" name="Vmax" value="2.42483"/> </listOfParameters> </kineticLaw> </reaction> <reaction metaid="COPASI48" id="reaction_20" name="nadph_ox" reversible="false"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI48"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2011-01-10T09:22:20Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfReactants> <speciesReference species="species_19"/> </listOfReactants> <listOfProducts> <speciesReference species="species_18"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> function_18 </ci> <ci> Vmax </ci> <ci> species_19 </ci> <ci> KmS </ci> <ci> species_18 </ci> <ci> KmP </ci> </apply> </apply> </math> <listOfParameters> <parameter id="Vmax" name="Vmax" value="78.9633"/> <parameter id="KmS" name="KmS" value="5.1477"/> <parameter id="KmP" name="KmP" value="13.0127"/> </listOfParameters> </kineticLaw> </reaction> <reaction metaid="COPASI49" id="reaction_21" name="PiT_active" reversible="false"> <annotation> <COPASI xmlns="http://www.copasi.org/static/sbml"> <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"> <rdf:Description rdf:about="#COPASI49"> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2010-09-20T14:34:45Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfReactants> <speciesReference species="species_22"/> <speciesReference species="species_10"/> </listOfReactants> <listOfProducts> <speciesReference species="species_8" stoichiometry="2"/> <speciesReference species="species_9"/> </listOfProducts> <kineticLaw> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <ci> function_19 </ci> <ci> Vmax </ci> <ci> species_22 </ci> <ci> KmS1 </ci> <ci> species_10 </ci> <ci> KmS2 </ci> <ci> species_9 </ci> <ci> KmP1 </ci> <ci> species_8 </ci> <ci> KmP2 </ci> </apply> </math> <listOfParameters> <parameter id="Vmax" name="Vmax" value="0.0871855"/> <parameter id="KmS1" name="KmS1" value="98.4058"/> <parameter id="KmS2" name="KmS2" value="89.2498"/> <parameter id="KmP1" name="KmP1" value="99.6366"/> <parameter id="KmP2" name="KmP2" value="0.360617"/> </listOfParameters> </kineticLaw> </reaction> </listOfReactions> </model> </sbml>