<sbml xmlns="http://www.sbml.org/sbml/level3/version1/core" level="3" version="1">
<model id="kolodkin3" name="kolodkin3" substanceUnits="nmol" timeUnits="min" volumeUnits="L" extentUnits="nMol">
<listOfFunctionDefinitions>
<functionDefinition id="TR" name="TR">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> Kapf </ci>
</bvar>
<bvar>
<ci> Cvar </ci>
</bvar>
<bvar>
<ci> Kapb </ci>
</bvar>
<bvar>
<ci> Nvar </ci>
</bvar>
<apply>
<minus/>
<apply>
<times/>
<ci> Cvar </ci>
<ci> Kapf </ci>
</apply>
<apply>
<times/>
<ci> Kapb </ci>
<ci> Nvar </ci>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
</listOfFunctionDefinitions>
<listOfUnitDefinitions>
<unitDefinition metaid="metaid_0" id="nmol" name="nmol">
<listOfUnits>
<unit kind="mole" exponent="1" scale="-9" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="metaid_1" id="L" name="L">
<listOfUnits>
<unit kind="litre" exponent="1" scale="0" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="metaid_2" id="min" name="min">
<listOfUnits>
<unit kind="second" exponent="1" scale="0" multiplier="60"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="metaid_3" id="nMol" name="nM">
<listOfUnits>
<unit kind="mole" exponent="1" scale="-9" multiplier="1"/>
<unit kind="litre" exponent="-1" scale="0" multiplier="1"/>
</listOfUnits>
</unitDefinition>
</listOfUnitDefinitions>
<listOfCompartments>
<compartment metaid="metaid_4" sboTerm="SBO:0000410" id="default_compartment" spatialDimensions="3" size="1" constant="true"/>
</listOfCompartments>
<listOfSpecies>
<species metaid="metaid_5" id="Lc" compartment="default_compartment" initialConcentration="0.005" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false"/>
<species metaid="metaid_6" id="Ln_" name="Ln" compartment="default_compartment" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species metaid="metaid_7" id="NRLc" compartment="default_compartment" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species metaid="metaid_8" id="NRLm" compartment="default_compartment" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species metaid="metaid_9" id="NRLn" compartment="default_compartment" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species metaid="metaid_10" id="NRc" compartment="default_compartment" initialConcentration="42" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species metaid="metaid_11" id="NRm" compartment="default_compartment" initialConcentration="42" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species metaid="metaid_12" id="NRn" compartment="default_compartment" initialConcentration="83.25" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species metaid="metaid_13" id="RE" compartment="default_compartment" initialConcentration="3.7" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species metaid="metaid_14" id="REL" compartment="default_compartment" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
</listOfSpecies>
<listOfParameters>
<parameter metaid="metaid_15" id="EXTERNAL" value="0" constant="false"/>
<parameter metaid="metaid_16" id="Kapb" value="3.24e-11" constant="false"/>
<parameter metaid="metaid_17" id="Kapb4" value="3.6" constant="false"/>
<parameter metaid="metaid_18" id="Kapb5" value="3.6" constant="false"/>
<parameter metaid="metaid_19" id="Kapf" value="3.24e-11" constant="false"/>
<parameter metaid="metaid_20" id="Kapf4" value="3.6" constant="false"/>
<parameter metaid="metaid_21" id="Kapf5" value="3.6" constant="false"/>
<parameter metaid="metaid_22" id="Vcytosol" value="1.55e-12" constant="false"/>
<parameter metaid="metaid_23" id="Vnucleus" value="4.5e-13" constant="false"/>
<parameter metaid="metaid_24" id="k1" value="60" constant="false"/>
<parameter metaid="metaid_25" id="k12" value="60" constant="false"/>
<parameter metaid="metaid_26" id="k13" value="60" constant="false"/>
<parameter metaid="metaid_27" id="k16" value="60" constant="false"/>
<parameter metaid="metaid_28" id="k2" value="60" constant="false"/>
<parameter metaid="metaid_29" id="k22" value="60" constant="false"/>
<parameter metaid="metaid_30" id="k23" value="60" constant="false"/>
<parameter metaid="metaid_31" id="k26" value="60" constant="false"/>
</listOfParameters>
<listOfReactions>
<reaction metaid="metaid_35" id="v_1" name="v_1" reversible="true" fast="false">
<listOfReactants>
<speciesReference metaid="metaid_32" species="NRLn" stoichiometry="1" constant="true"/>
<speciesReference metaid="metaid_33" species="RE" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="metaid_34" species="REL" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> k1 </ci>
<ci> NRLn </ci>
<ci> RE </ci>
</apply>
<apply>
<times/>
<ci> k2 </ci>
<ci> REL </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="metaid_38" id="v_2" name="v_2" reversible="true" fast="false">
<listOfReactants>
<speciesReference metaid="metaid_36" species="Lc" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="metaid_37" species="Ln_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<ci> TR </ci>
<ci> Kapf </ci>
<ci> Lc </ci>
<ci> Kapb </ci>
<ci> Ln_ </ci>
</apply>
<ci> Vnucleus </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="metaid_42" id="v_3" name="v_3" reversible="true" fast="false">
<listOfReactants>
<speciesReference metaid="metaid_39" species="Ln_" stoichiometry="1" constant="true"/>
<speciesReference metaid="metaid_40" species="NRn" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="metaid_41" species="NRLn" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci> k22 </ci>
<ci> NRLn </ci>
</apply>
</apply>
<apply>
<times/>
<ci> k12 </ci>
<ci> Ln_ </ci>
<ci> NRn </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="metaid_46" id="v_4" name="v_4" reversible="true" fast="false">
<listOfReactants>
<speciesReference metaid="metaid_43" species="NRm" stoichiometry="1" constant="true"/>
<speciesReference metaid="metaid_44" species="Ln_" stoichiometry="3.44444444444" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="metaid_45" species="NRLm" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<times/>
<ci> Vnucleus </ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci> k23 </ci>
<ci> NRLm </ci>
</apply>
</apply>
<apply>
<times/>
<ci> k13 </ci>
<ci> Ln_ </ci>
<ci> NRm </ci>
</apply>
</apply>
</apply>
<ci> Vcytosol </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="metaid_49" id="v_5" reversible="true" fast="false">
<listOfReactants>
<speciesReference metaid="metaid_47" species="NRc" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="metaid_48" species="NRm" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<ci> TR </ci>
<ci> Kapf4 </ci>
<ci> NRc </ci>
<ci> Kapb4 </ci>
<ci> NRm </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="metaid_52" id="v_6" reversible="true" fast="false">
<listOfReactants>
<speciesReference metaid="metaid_50" species="NRLc" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="metaid_51" species="NRLm" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<ci> TR </ci>
<ci> Kapf5 </ci>
<ci> NRLc </ci>
<ci> Kapb5 </ci>
<ci> NRLm </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="metaid_63" id="v_7" name="v_7" reversible="true" fast="false">
<listOfReactants>
<speciesReference metaid="metaid_53" species="NRc" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="metaid_54" species="NRLc" stoichiometry="1" constant="true"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="metaid_55" species="NRLn"/>
<modifierSpeciesReference metaid="metaid_56" species="RE"/>
<modifierSpeciesReference metaid="metaid_57" species="Ln_"/>
<modifierSpeciesReference metaid="metaid_58" species="NRm"/>
<modifierSpeciesReference metaid="metaid_59" species="REL"/>
<modifierSpeciesReference metaid="metaid_60" species="NRn"/>
<modifierSpeciesReference metaid="metaid_61" species="NRLm"/>
<modifierSpeciesReference metaid="metaid_62" species="Lc"/>
</listOfModifiers>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci> k16 </ci>
<ci> Lc </ci>
<ci> NRc </ci>
</apply>
<apply>
<times/>
<ci> k26 </ci>
<ci> NRLc </ci>
</apply>
</apply>
<apply>
<times/>
<cn type="integer"> 0 </cn>
<ci> NRLn </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 0 </cn>
<ci> RE </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 0 </cn>
<ci> Ln_ </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 0 </cn>
<ci> NRn </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 0 </cn>
<ci> NRm </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 0 </cn>
<ci> NRc </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 0 </cn>
<ci> NRLc </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 0 </cn>
<ci> REL </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 0 </cn>
<ci> NRLm </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 0 </cn>
<ci> NRLn </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 0 </cn>
<ci> RE </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 0 </cn>
<ci> Ln_ </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 0 </cn>
<ci> NRn </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 0 </cn>
<ci> NRm </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 0 </cn>
<ci> NRc </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 0 </cn>
<ci> NRLc </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 0 </cn>
<ci> REL </ci>
</apply>
<apply>
<times/>
<cn type="integer"> 0 </cn>
<ci> NRLm </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
</listOfReactions>
</model>
</sbml>