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<COPASI xmlns="http://www.copasi.org/static/schema" versionMajor="4" versionMinor="9" versionDevel="45" copasiSourcesModified="0">
<ListOfFunctions>
<Function key="Function_40" name="Function for v1" type="UserDefined" reversible="true">
<Expression>
(k1*A*E-k1a*EA)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_254" name="A" order="0" role="substrate"/>
<ParameterDescription key="FunctionParameter_270" name="Cell" order="1" role="volume"/>
<ParameterDescription key="FunctionParameter_258" name="E" order="2" role="substrate"/>
<ParameterDescription key="FunctionParameter_268" name="EA" order="3" role="product"/>
<ParameterDescription key="FunctionParameter_264" name="k1" order="4" role="constant"/>
<ParameterDescription key="FunctionParameter_266" name="k1a" order="5" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_41" name="Function for v2" type="UserDefined" reversible="true">
<Expression>
(k2*EA*B-k2a*EAB)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_246" name="B" order="0" role="substrate"/>
<ParameterDescription key="FunctionParameter_276" name="Cell" order="1" role="volume"/>
<ParameterDescription key="FunctionParameter_267" name="EA" order="2" role="substrate"/>
<ParameterDescription key="FunctionParameter_274" name="EAB" order="3" role="product"/>
<ParameterDescription key="FunctionParameter_271" name="k2" order="4" role="constant"/>
<ParameterDescription key="FunctionParameter_272" name="k2a" order="5" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_42" name="Function for v3" type="UserDefined" reversible="true">
<Expression>
(k3*E*B-k3a*EB)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_265" name="B" order="0" role="substrate"/>
<ParameterDescription key="FunctionParameter_282" name="Cell" order="1" role="volume"/>
<ParameterDescription key="FunctionParameter_273" name="E" order="2" role="substrate"/>
<ParameterDescription key="FunctionParameter_280" name="EB" order="3" role="product"/>
<ParameterDescription key="FunctionParameter_277" name="k3" order="4" role="constant"/>
<ParameterDescription key="FunctionParameter_278" name="k3a" order="5" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_43" name="Function for v4" type="UserDefined" reversible="true">
<Expression>
(k4*EB*A-k4a*EAB)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_262" name="A" order="0" role="substrate"/>
<ParameterDescription key="FunctionParameter_288" name="Cell" order="1" role="volume"/>
<ParameterDescription key="FunctionParameter_286" name="EAB" order="2" role="product"/>
<ParameterDescription key="FunctionParameter_279" name="EB" order="3" role="substrate"/>
<ParameterDescription key="FunctionParameter_283" name="k4" order="4" role="constant"/>
<ParameterDescription key="FunctionParameter_284" name="k4a" order="5" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_44" name="Function for v5" type="UserDefined" reversible="true">
<Expression>
(k5*EAB*Q-k5a*EABQ)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_294" name="Cell" order="0" role="volume"/>
<ParameterDescription key="FunctionParameter_285" name="EAB" order="1" role="substrate"/>
<ParameterDescription key="FunctionParameter_292" name="EABQ" order="2" role="product"/>
<ParameterDescription key="FunctionParameter_269" name="Q" order="3" role="substrate"/>
<ParameterDescription key="FunctionParameter_289" name="k5" order="4" role="constant"/>
<ParameterDescription key="FunctionParameter_290" name="k5a" order="5" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_45" name="Function for v6" type="UserDefined" reversible="true">
<Expression>
(k6*EA*Q-k6a*EAQ)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_300" name="Cell" order="0" role="volume"/>
<ParameterDescription key="FunctionParameter_291" name="EA" order="1" role="substrate"/>
<ParameterDescription key="FunctionParameter_298" name="EAQ" order="2" role="product"/>
<ParameterDescription key="FunctionParameter_275" name="Q" order="3" role="substrate"/>
<ParameterDescription key="FunctionParameter_295" name="k6" order="4" role="constant"/>
<ParameterDescription key="FunctionParameter_296" name="k6a" order="5" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_46" name="Function for v7" type="UserDefined" reversible="true">
<Expression>
(k7*EB*Q-k7a*EBQ)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_306" name="Cell" order="0" role="volume"/>
<ParameterDescription key="FunctionParameter_297" name="EB" order="1" role="substrate"/>
<ParameterDescription key="FunctionParameter_304" name="EBQ" order="2" role="product"/>
<ParameterDescription key="FunctionParameter_281" name="Q" order="3" role="substrate"/>
<ParameterDescription key="FunctionParameter_301" name="k7" order="4" role="constant"/>
<ParameterDescription key="FunctionParameter_302" name="k7a" order="5" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_47" name="Function for v8" type="UserDefined" reversible="true">
<MiriamAnnotation>
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<rdf:Description>
<dcterms:W3CDTF>2013-04-09T09:57:40Z</dcterms:W3CDTF>
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</MiriamAnnotation>
<Expression>
(k8*E*Q- k8a*EQ)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_312" name="Cell" order="0" role="volume"/>
<ParameterDescription key="FunctionParameter_303" name="E" order="1" role="substrate"/>
<ParameterDescription key="FunctionParameter_310" name="EQ" order="2" role="product"/>
<ParameterDescription key="FunctionParameter_287" name="Q" order="3" role="substrate"/>
<ParameterDescription key="FunctionParameter_307" name="k8" order="4" role="constant"/>
<ParameterDescription key="FunctionParameter_308" name="k8a" order="5" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_48" name="Function for v9" type="UserDefined" reversible="true">
<Expression>
(k9*EQ*A-k9a*EAQ)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_293" name="A" order="0" role="substrate"/>
<ParameterDescription key="FunctionParameter_318" name="Cell" order="1" role="volume"/>
<ParameterDescription key="FunctionParameter_316" name="EAQ" order="2" role="product"/>
<ParameterDescription key="FunctionParameter_309" name="EQ" order="3" role="substrate"/>
<ParameterDescription key="FunctionParameter_313" name="k9" order="4" role="constant"/>
<ParameterDescription key="FunctionParameter_314" name="k9a" order="5" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_49" name="Function for v10" type="UserDefined" reversible="true">
<Expression>
(k10*EAQ*B-k10a*EABQ)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_299" name="B" order="0" role="substrate"/>
<ParameterDescription key="FunctionParameter_324" name="Cell" order="1" role="volume"/>
<ParameterDescription key="FunctionParameter_322" name="EABQ" order="2" role="product"/>
<ParameterDescription key="FunctionParameter_315" name="EAQ" order="3" role="substrate"/>
<ParameterDescription key="FunctionParameter_319" name="k10" order="4" role="constant"/>
<ParameterDescription key="FunctionParameter_320" name="k10a" order="5" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_50" name="Function for v11" type="UserDefined" reversible="true">
<Expression>
(k11*EQ*B-k11a*EBQ)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_305" name="B" order="0" role="substrate"/>
<ParameterDescription key="FunctionParameter_330" name="Cell" order="1" role="volume"/>
<ParameterDescription key="FunctionParameter_328" name="EBQ" order="2" role="product"/>
<ParameterDescription key="FunctionParameter_321" name="EQ" order="3" role="substrate"/>
<ParameterDescription key="FunctionParameter_325" name="k11" order="4" role="constant"/>
<ParameterDescription key="FunctionParameter_326" name="k11a" order="5" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_51" name="Function for v12" type="UserDefined" reversible="true">
<Expression>
(k12*EBQ*A-k12a*EABQ)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_311" name="A" order="0" role="substrate"/>
<ParameterDescription key="FunctionParameter_336" name="Cell" order="1" role="volume"/>
<ParameterDescription key="FunctionParameter_334" name="EABQ" order="2" role="product"/>
<ParameterDescription key="FunctionParameter_327" name="EBQ" order="3" role="substrate"/>
<ParameterDescription key="FunctionParameter_331" name="k12" order="4" role="constant"/>
<ParameterDescription key="FunctionParameter_332" name="k12a" order="5" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_52" name="Function for v13" type="UserDefined" reversible="false">
<Expression>
k13*EABQ/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_317" name="Cell" order="0" role="volume"/>
<ParameterDescription key="FunctionParameter_333" name="EABQ" order="1" role="substrate"/>
<ParameterDescription key="FunctionParameter_337" name="k13" order="2" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_53" name="Function for v14" type="UserDefined" reversible="true">
<Expression>
(k14*XQ-k14a*ER)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_343" name="Cell" order="0" role="volume"/>
<ParameterDescription key="FunctionParameter_341" name="ER" order="1" role="product"/>
<ParameterDescription key="FunctionParameter_335" name="XQ" order="2" role="substrate"/>
<ParameterDescription key="FunctionParameter_329" name="k14" order="3" role="constant"/>
<ParameterDescription key="FunctionParameter_339" name="k14a" order="4" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_54" name="Function for v15" type="UserDefined" reversible="true">
<Expression>
(k15*ER-k15a*E*R)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_350" name="Cell" order="0" role="volume"/>
<ParameterDescription key="FunctionParameter_346" name="E" order="1" role="product"/>
<ParameterDescription key="FunctionParameter_340" name="ER" order="2" role="substrate"/>
<ParameterDescription key="FunctionParameter_348" name="R" order="3" role="product"/>
<ParameterDescription key="FunctionParameter_344" name="k15" order="4" role="constant"/>
<ParameterDescription key="FunctionParameter_323" name="k15a" order="5" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_55" name="Function for v16" type="UserDefined" reversible="true">
<Expression>
(k16*XQ*B-k16a*XQ_B)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_338" name="B" order="0" role="substrate"/>
<ParameterDescription key="FunctionParameter_356" name="Cell" order="1" role="volume"/>
<ParameterDescription key="FunctionParameter_347" name="XQ" order="2" role="substrate"/>
<ParameterDescription key="FunctionParameter_354" name="XQ_B" order="3" role="product"/>
<ParameterDescription key="FunctionParameter_351" name="k16" order="4" role="constant"/>
<ParameterDescription key="FunctionParameter_352" name="k16a" order="5" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_56" name="Function for v17" type="UserDefined" reversible="true">
<Expression>
(k17*XQ*R-k17a*XQ_R)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_362" name="Cell" order="0" role="volume"/>
<ParameterDescription key="FunctionParameter_345" name="R" order="1" role="substrate"/>
<ParameterDescription key="FunctionParameter_353" name="XQ" order="2" role="substrate"/>
<ParameterDescription key="FunctionParameter_360" name="XQ_R" order="3" role="product"/>
<ParameterDescription key="FunctionParameter_357" name="k17" order="4" role="constant"/>
<ParameterDescription key="FunctionParameter_358" name="k17a" order="5" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_57" name="Function for v19" type="UserDefined" reversible="true">
<Expression>
(k19*E*C-k19a*EC)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_342" name="C" order="0" role="substrate"/>
<ParameterDescription key="FunctionParameter_368" name="Cell" order="1" role="volume"/>
<ParameterDescription key="FunctionParameter_359" name="E" order="2" role="substrate"/>
<ParameterDescription key="FunctionParameter_366" name="EC" order="3" role="product"/>
<ParameterDescription key="FunctionParameter_363" name="k19" order="4" role="constant"/>
<ParameterDescription key="FunctionParameter_364" name="k19a" order="5" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_58" name="Function for v20" type="UserDefined" reversible="true">
<Expression>
(k20*EC*A-k20a*EAC)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_349" name="A" order="0" role="substrate"/>
<ParameterDescription key="FunctionParameter_374" name="Cell" order="1" role="volume"/>
<ParameterDescription key="FunctionParameter_372" name="EAC" order="2" role="product"/>
<ParameterDescription key="FunctionParameter_365" name="EC" order="3" role="substrate"/>
<ParameterDescription key="FunctionParameter_369" name="k20" order="4" role="constant"/>
<ParameterDescription key="FunctionParameter_370" name="k20a" order="5" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_59" name="Function for v21" type="UserDefined" reversible="true">
<Expression>
(k21*EAC*B-k21a*EABC)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_355" name="B" order="0" role="substrate"/>
<ParameterDescription key="FunctionParameter_380" name="Cell" order="1" role="volume"/>
<ParameterDescription key="FunctionParameter_378" name="EABC" order="2" role="product"/>
<ParameterDescription key="FunctionParameter_371" name="EAC" order="3" role="substrate"/>
<ParameterDescription key="FunctionParameter_375" name="k21" order="4" role="constant"/>
<ParameterDescription key="FunctionParameter_376" name="k21a" order="5" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_60" name="Function for v22" type="UserDefined" reversible="true">
<Expression>
(k22*EC*B-k22a*EBC)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_361" name="B" order="0" role="substrate"/>
<ParameterDescription key="FunctionParameter_386" name="Cell" order="1" role="volume"/>
<ParameterDescription key="FunctionParameter_384" name="EBC" order="2" role="product"/>
<ParameterDescription key="FunctionParameter_377" name="EC" order="3" role="substrate"/>
<ParameterDescription key="FunctionParameter_381" name="k22" order="4" role="constant"/>
<ParameterDescription key="FunctionParameter_382" name="k22a" order="5" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_61" name="Function for v23" type="UserDefined" reversible="true">
<Expression>
(k23*EBC*A-k23a*EABC)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_367" name="A" order="0" role="substrate"/>
<ParameterDescription key="FunctionParameter_392" name="Cell" order="1" role="volume"/>
<ParameterDescription key="FunctionParameter_390" name="EABC" order="2" role="product"/>
<ParameterDescription key="FunctionParameter_383" name="EBC" order="3" role="substrate"/>
<ParameterDescription key="FunctionParameter_387" name="k23" order="4" role="constant"/>
<ParameterDescription key="FunctionParameter_388" name="k23a" order="5" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_62" name="Function for v24" type="UserDefined" reversible="true">
<Expression>
(k24*EA*C-k24a*EAC)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_373" name="C" order="0" role="substrate"/>
<ParameterDescription key="FunctionParameter_398" name="Cell" order="1" role="volume"/>
<ParameterDescription key="FunctionParameter_389" name="EA" order="2" role="substrate"/>
<ParameterDescription key="FunctionParameter_396" name="EAC" order="3" role="product"/>
<ParameterDescription key="FunctionParameter_393" name="k24" order="4" role="constant"/>
<ParameterDescription key="FunctionParameter_394" name="k24a" order="5" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_63" name="Function for v25" type="UserDefined" reversible="true">
<Expression>
(k25*EB*C-k25a*EBC)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_379" name="C" order="0" role="substrate"/>
<ParameterDescription key="FunctionParameter_404" name="Cell" order="1" role="volume"/>
<ParameterDescription key="FunctionParameter_395" name="EB" order="2" role="substrate"/>
<ParameterDescription key="FunctionParameter_402" name="EBC" order="3" role="product"/>
<ParameterDescription key="FunctionParameter_399" name="k25" order="4" role="constant"/>
<ParameterDescription key="FunctionParameter_400" name="k25a" order="5" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_64" name="Function for v26" type="UserDefined" reversible="true">
<Expression>
(k26*EAB*C-k26a*EABC)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_385" name="C" order="0" role="substrate"/>
<ParameterDescription key="FunctionParameter_410" name="Cell" order="1" role="volume"/>
<ParameterDescription key="FunctionParameter_401" name="EAB" order="2" role="substrate"/>
<ParameterDescription key="FunctionParameter_408" name="EABC" order="3" role="product"/>
<ParameterDescription key="FunctionParameter_405" name="k26" order="4" role="constant"/>
<ParameterDescription key="FunctionParameter_406" name="k26a" order="5" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_65" name="Function for v27" type="UserDefined" reversible="false">
<Expression>
k27*EABC/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_391" name="Cell" order="0" role="volume"/>
<ParameterDescription key="FunctionParameter_407" name="EABC" order="1" role="substrate"/>
<ParameterDescription key="FunctionParameter_411" name="k27" order="2" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_66" name="Function for v28" type="UserDefined" reversible="true">
<Expression>
(k28*XC-k28a*E_Q)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_417" name="Cell" order="0" role="volume"/>
<ParameterDescription key="FunctionParameter_415" name="E_Q" order="1" role="product"/>
<ParameterDescription key="FunctionParameter_409" name="XC" order="2" role="substrate"/>
<ParameterDescription key="FunctionParameter_403" name="k28" order="3" role="constant"/>
<ParameterDescription key="FunctionParameter_413" name="k28a" order="4" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_67" name="Function for v29" type="UserDefined" reversible="true">
<Expression>
(k29*E_Q-k29a*E*Q)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_424" name="Cell" order="0" role="volume"/>
<ParameterDescription key="FunctionParameter_420" name="E" order="1" role="product"/>
<ParameterDescription key="FunctionParameter_414" name="E_Q" order="2" role="substrate"/>
<ParameterDescription key="FunctionParameter_422" name="Q" order="3" role="product"/>
<ParameterDescription key="FunctionParameter_418" name="k29" order="4" role="constant"/>
<ParameterDescription key="FunctionParameter_397" name="k29a" order="5" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_68" name="Function for v30" type="UserDefined" reversible="true">
<Expression>
(k30*XC*B-k30a*XC_B)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_412" name="B" order="0" role="substrate"/>
<ParameterDescription key="FunctionParameter_430" name="Cell" order="1" role="volume"/>
<ParameterDescription key="FunctionParameter_421" name="XC" order="2" role="substrate"/>
<ParameterDescription key="FunctionParameter_428" name="XC_B" order="3" role="product"/>
<ParameterDescription key="FunctionParameter_425" name="k30" order="4" role="constant"/>
<ParameterDescription key="FunctionParameter_426" name="k30a" order="5" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_69" name="Function for v31" type="UserDefined" reversible="true">
<Expression>
(k31*XC*R-k31a*XC_R)/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_436" name="Cell" order="0" role="volume"/>
<ParameterDescription key="FunctionParameter_419" name="R" order="1" role="substrate"/>
<ParameterDescription key="FunctionParameter_427" name="XC" order="2" role="substrate"/>
<ParameterDescription key="FunctionParameter_434" name="XC_R" order="3" role="product"/>
<ParameterDescription key="FunctionParameter_431" name="k31" order="4" role="constant"/>
<ParameterDescription key="FunctionParameter_432" name="k31a" order="5" role="constant"/>
</ListOfParameterDescriptions>
</Function>
<Function key="Function_70" name="Function for v32" type="UserDefined" reversible="false">
<Expression>
k32*P/Cell
</Expression>
<ListOfParameterDescriptions>
<ParameterDescription key="FunctionParameter_416" name="Cell" order="0" role="volume"/>
<ParameterDescription key="FunctionParameter_433" name="P" order="1" role="substrate"/>
<ParameterDescription key="FunctionParameter_437" name="k32" order="2" role="constant"/>
</ListOfParameterDescriptions>
</Function>
</ListOfFunctions>
<Model key="Model_0" name="TryS_119" simulationType="time" timeUnit="s" volumeUnit="l" areaUnit="m²" lengthUnit="m" quantityUnit="µmol" type="deterministic" avogadroConstant="6.02214179e+023">
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</MiriamAnnotation>
<ListOfCompartments>
<Compartment key="Compartment_0" name="Cell" simulationType="fixed" dimensionality="3">
</Compartment>
</ListOfCompartments>
<ListOfMetabolites>
<Metabolite key="Metabolite_0" name="A" simulationType="fixed" compartment="Compartment_0">
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<Metabolite key="Metabolite_1" name="C" simulationType="fixed" compartment="Compartment_0">
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<Metabolite key="Metabolite_2" name="B" simulationType="fixed" compartment="Compartment_0">
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<Metabolite key="Metabolite_3" name="E" simulationType="reactions" compartment="Compartment_0">
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<ModelValue key="ModelValue_33" name="k19" simulationType="assignment">
<MiriamAnnotation>
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</MiriamAnnotation>
<Expression>
<CN=Root,Model=TryS_119,Vector=Values[k19a],Reference=InitialValue>*<CN=Root,Model=TryS_119,Vector=Values[k22a],Reference=InitialValue>*<CN=Root,Model=TryS_119,Vector=Values[k25],Reference=InitialValue>*<CN=Root,Model=TryS_119,Vector=Values[k3],Reference=InitialValue>/(<CN=Root,Model=TryS_119,Vector=Values[k22],Reference=InitialValue>*<CN=Root,Model=TryS_119,Vector=Values[k25a],Reference=InitialValue>*<CN=Root,Model=TryS_119,Vector=Values[k3a],Reference=InitialValue>)
</Expression>
</ModelValue>
<ModelValue key="ModelValue_34" name="k19a" simulationType="fixed">
<MiriamAnnotation>
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<rdf:Description rdf:about="#ModelValue_34">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2013-03-22T12:37:28Z</dcterms:W3CDTF>
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</MiriamAnnotation>
</ModelValue>
<ModelValue key="ModelValue_35" name="k20" simulationType="assignment">
<MiriamAnnotation>
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<Expression>
<CN=Root,Model=TryS_119,Vector=Values[k20a],Reference=InitialValue>*<CN=Root,Model=TryS_119,Vector=Values[k19a],Reference=InitialValue>*<CN=Root,Model=TryS_119,Vector=Values[k24],Reference=InitialValue>*<CN=Root,Model=TryS_119,Vector=Values[k1],Reference=InitialValue>/(<CN=Root,Model=TryS_119,Vector=Values[k19],Reference=InitialValue>*<CN=Root,Model=TryS_119,Vector=Values[k24a],Reference=InitialValue>*<CN=Root,Model=TryS_119,Vector=Values[k1a],Reference=InitialValue>)
</Expression>
</ModelValue>
<ModelValue key="ModelValue_36" name="k20a" simulationType="fixed">
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<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2013-03-22T12:37:30Z</dcterms:W3CDTF>
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</MiriamAnnotation>
</ModelValue>
<ModelValue key="ModelValue_37" name="k21" simulationType="fixed">
<MiriamAnnotation>
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<rdf:Description rdf:about="#ModelValue_37">
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<rdf:Description>
<dcterms:W3CDTF>2013-03-22T12:34:26Z</dcterms:W3CDTF>
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</MiriamAnnotation>
</ModelValue>
<ModelValue key="ModelValue_38" name="k21a" simulationType="fixed">
<MiriamAnnotation>
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<rdf:Description rdf:about="#ModelValue_38">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2013-03-22T12:37:50Z</dcterms:W3CDTF>
</rdf:Description>
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</rdf:RDF>
</MiriamAnnotation>
</ModelValue>
<ModelValue key="ModelValue_39" name="k22" simulationType="fixed">
</ModelValue>
<ModelValue key="ModelValue_40" name="k22a" simulationType="fixed">
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<ModelValue key="ModelValue_41" name="k23" simulationType="fixed">
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<ModelValue key="ModelValue_42" name="k23a" simulationType="fixed">
</ModelValue>
<ModelValue key="ModelValue_43" name="k24" simulationType="assignment">
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<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2013-03-22T12:28:08Z</dcterms:W3CDTF>
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</dcterms:created>
</rdf:Description>
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</MiriamAnnotation>
<Expression>
<CN=Root,Model=TryS_119,Vector=Values[k24a],Reference=InitialValue>*<CN=Root,Model=TryS_119,Vector=Values[k21a],Reference=InitialValue>*<CN=Root,Model=TryS_119,Vector=Values[k26],Reference=InitialValue>*<CN=Root,Model=TryS_119,Vector=Values[k2],Reference=InitialValue>/(<CN=Root,Model=TryS_119,Vector=Values[k21],Reference=InitialValue>*<CN=Root,Model=TryS_119,Vector=Values[k26a],Reference=InitialValue>*<CN=Root,Model=TryS_119,Vector=Values[k2a],Reference=InitialValue>)
</Expression>
</ModelValue>
<ModelValue key="ModelValue_44" name="k24a" simulationType="fixed">
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<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2013-03-22T12:33:49Z</dcterms:W3CDTF>
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</MiriamAnnotation>
</ModelValue>
<ModelValue key="ModelValue_45" name="k25" simulationType="assignment">
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<rdf:Description rdf:about="#ModelValue_45">
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<dcterms:W3CDTF>2013-03-22T12:31:45Z</dcterms:W3CDTF>
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</rdf:Description>
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</MiriamAnnotation>
<Expression>
<CN=Root,Model=TryS_119,Vector=Values[k25a],Reference=InitialValue>*<CN=Root,Model=TryS_119,Vector=Values[k23a],Reference=InitialValue>*<CN=Root,Model=TryS_119,Vector=Values[k26],Reference=InitialValue>*<CN=Root,Model=TryS_119,Vector=Values[k4],Reference=InitialValue>/(<CN=Root,Model=TryS_119,Vector=Values[k23],Reference=InitialValue>*<CN=Root,Model=TryS_119,Vector=Values[k26a],Reference=InitialValue>*<CN=Root,Model=TryS_119,Vector=Values[k4a],Reference=InitialValue>)
</Expression>
</ModelValue>
<ModelValue key="ModelValue_46" name="k25a" simulationType="fixed">
</ModelValue>
<ModelValue key="ModelValue_47" name="k26" simulationType="fixed">
</ModelValue>
<ModelValue key="ModelValue_48" name="k26a" simulationType="fixed">
</ModelValue>
<ModelValue key="ModelValue_49" name="k27" simulationType="fixed">
</ModelValue>
<ModelValue key="ModelValue_50" name="k28" simulationType="fixed">
</ModelValue>
<ModelValue key="ModelValue_51" name="k28a" simulationType="fixed">
</ModelValue>
<ModelValue key="ModelValue_52" name="k29" simulationType="fixed">
</ModelValue>
<ModelValue key="ModelValue_53" name="k29a" simulationType="fixed">
</ModelValue>
<ModelValue key="ModelValue_54" name="k30" simulationType="fixed">
</ModelValue>
<ModelValue key="ModelValue_55" name="k30a" simulationType="fixed">
</ModelValue>
<ModelValue key="ModelValue_56" name="k31" simulationType="fixed">
</ModelValue>
<ModelValue key="ModelValue_57" name="k31a" simulationType="fixed">
</ModelValue>
<ModelValue key="ModelValue_58" name="k32" simulationType="fixed">
</ModelValue>
</ListOfModelValues>
<ListOfReactions>
<Reaction key="Reaction_0" name="v1" reversible="true">
<MiriamAnnotation>
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<rdf:Description rdf:about="#Reaction_0">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2013-03-21T17:13:48Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</MiriamAnnotation>
<ListOfSubstrates>
<Substrate metabolite="Metabolite_0" stoichiometry="1"/>
<Substrate metabolite="Metabolite_3" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_5" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_1614" name="k1" value="13.4954"/>
<Constant key="Parameter_1615" name="k1a" value="134.294"/>
</ListOfConstants>
<KineticLaw function="Function_40">
<ListOfCallParameters>
<CallParameter functionParameter="FunctionParameter_254">
<SourceParameter reference="Metabolite_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_270">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_258">
<SourceParameter reference="Metabolite_3"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_268">
<SourceParameter reference="Metabolite_5"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_264">
<SourceParameter reference="ModelValue_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_266">
<SourceParameter reference="ModelValue_1"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_1" name="v2" reversible="true">
<ListOfSubstrates>
<Substrate metabolite="Metabolite_2" stoichiometry="1"/>
<Substrate metabolite="Metabolite_5" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_18" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_1616" name="k2" value="1"/>
<Constant key="Parameter_1617" name="k2a" value="1"/>
</ListOfConstants>
<KineticLaw function="Function_41">
<ListOfCallParameters>
<CallParameter functionParameter="FunctionParameter_246">
<SourceParameter reference="Metabolite_2"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_276">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_267">
<SourceParameter reference="Metabolite_5"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_274">
<SourceParameter reference="Metabolite_18"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_271">
<SourceParameter reference="ModelValue_2"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_272">
<SourceParameter reference="ModelValue_3"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_2" name="v3" reversible="true">
<ListOfSubstrates>
<Substrate metabolite="Metabolite_2" stoichiometry="1"/>
<Substrate metabolite="Metabolite_3" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_7" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_1618" name="k3" value="1"/>
<Constant key="Parameter_1619" name="k3a" value="1"/>
</ListOfConstants>
<KineticLaw function="Function_42">
<ListOfCallParameters>
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<CallParameter functionParameter="FunctionParameter_282">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_273">
<SourceParameter reference="Metabolite_3"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_280">
<SourceParameter reference="Metabolite_7"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_277">
<SourceParameter reference="ModelValue_4"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_278">
<SourceParameter reference="ModelValue_5"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_3" name="v4" reversible="true">
<MiriamAnnotation>
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<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2013-03-24T19:13:48Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
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</MiriamAnnotation>
<ListOfSubstrates>
<Substrate metabolite="Metabolite_0" stoichiometry="1"/>
<Substrate metabolite="Metabolite_7" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_18" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_1620" name="k4" value="762.267"/>
<Constant key="Parameter_1621" name="k4a" value="39.715"/>
</ListOfConstants>
<KineticLaw function="Function_43">
<ListOfCallParameters>
<CallParameter functionParameter="FunctionParameter_262">
<SourceParameter reference="Metabolite_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_288">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_286">
<SourceParameter reference="Metabolite_18"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_279">
<SourceParameter reference="Metabolite_7"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_283">
<SourceParameter reference="ModelValue_6"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_284">
<SourceParameter reference="ModelValue_7"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_4" name="v5" reversible="true">
<ListOfSubstrates>
<Substrate metabolite="Metabolite_8" stoichiometry="1"/>
<Substrate metabolite="Metabolite_18" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_20" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
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<Constant key="Parameter_1623" name="k5a" value="1"/>
</ListOfConstants>
<KineticLaw function="Function_44">
<ListOfCallParameters>
<CallParameter functionParameter="FunctionParameter_294">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_285">
<SourceParameter reference="Metabolite_18"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_292">
<SourceParameter reference="Metabolite_20"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_269">
<SourceParameter reference="Metabolite_8"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_289">
<SourceParameter reference="ModelValue_8"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_290">
<SourceParameter reference="ModelValue_9"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_5" name="v6" reversible="true">
<ListOfSubstrates>
<Substrate metabolite="Metabolite_8" stoichiometry="1"/>
<Substrate metabolite="Metabolite_5" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_22" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_1624" name="k6" value="1"/>
<Constant key="Parameter_1625" name="k6a" value="1"/>
</ListOfConstants>
<KineticLaw function="Function_45">
<ListOfCallParameters>
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<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_291">
<SourceParameter reference="Metabolite_5"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_298">
<SourceParameter reference="Metabolite_22"/>
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<CallParameter functionParameter="FunctionParameter_275">
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<CallParameter functionParameter="FunctionParameter_295">
<SourceParameter reference="ModelValue_10"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_296">
<SourceParameter reference="ModelValue_11"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_6" name="v7" reversible="true">
<ListOfSubstrates>
<Substrate metabolite="Metabolite_8" stoichiometry="1"/>
<Substrate metabolite="Metabolite_7" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_21" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_1626" name="k7" value="1"/>
<Constant key="Parameter_1627" name="k7a" value="1"/>
</ListOfConstants>
<KineticLaw function="Function_46">
<ListOfCallParameters>
<CallParameter functionParameter="FunctionParameter_306">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_297">
<SourceParameter reference="Metabolite_7"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_304">
<SourceParameter reference="Metabolite_21"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_281">
<SourceParameter reference="Metabolite_8"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_301">
<SourceParameter reference="ModelValue_12"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_302">
<SourceParameter reference="ModelValue_13"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_7" name="v8" reversible="true">
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<rdf:Description rdf:about="#Reaction_7">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2013-04-09T09:57:31Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</MiriamAnnotation>
<ListOfSubstrates>
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<Substrate metabolite="Metabolite_8" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_13" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
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<Constant key="Parameter_1629" name="k8a" value="237.469"/>
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<KineticLaw function="Function_47">
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<CallParameter functionParameter="FunctionParameter_303">
<SourceParameter reference="Metabolite_3"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_310">
<SourceParameter reference="Metabolite_13"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_287">
<SourceParameter reference="Metabolite_8"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_307">
<SourceParameter reference="ModelValue_15"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_308">
<SourceParameter reference="ModelValue_14"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_8" name="v9" reversible="true">
<MiriamAnnotation>
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<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2013-03-26T10:57:45Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
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</MiriamAnnotation>
<ListOfSubstrates>
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<Substrate metabolite="Metabolite_13" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_22" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
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<Constant key="Parameter_1631" name="k9a" value="29.8764"/>
</ListOfConstants>
<KineticLaw function="Function_48">
<ListOfCallParameters>
<CallParameter functionParameter="FunctionParameter_293">
<SourceParameter reference="Metabolite_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_318">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_316">
<SourceParameter reference="Metabolite_22"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_309">
<SourceParameter reference="Metabolite_13"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_313">
<SourceParameter reference="ModelValue_16"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_314">
<SourceParameter reference="ModelValue_17"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_9" name="v10" reversible="true">
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<Substrate metabolite="Metabolite_22" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_20" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
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<Constant key="Parameter_1633" name="k10a" value="1"/>
</ListOfConstants>
<KineticLaw function="Function_49">
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<SourceParameter reference="Metabolite_2"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_324">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_322">
<SourceParameter reference="Metabolite_20"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_315">
<SourceParameter reference="Metabolite_22"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_319">
<SourceParameter reference="ModelValue_18"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_320">
<SourceParameter reference="ModelValue_19"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_10" name="v11" reversible="true">
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<Substrate metabolite="Metabolite_13" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_21" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
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<Constant key="Parameter_1635" name="k11a" value="1"/>
</ListOfConstants>
<KineticLaw function="Function_50">
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<SourceParameter reference="Metabolite_2"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_330">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_328">
<SourceParameter reference="Metabolite_21"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_321">
<SourceParameter reference="Metabolite_13"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_325">
<SourceParameter reference="ModelValue_20"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_326">
<SourceParameter reference="ModelValue_21"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_11" name="v12" reversible="true">
<ListOfSubstrates>
<Substrate metabolite="Metabolite_21" stoichiometry="1"/>
<Substrate metabolite="Metabolite_0" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_20" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_1636" name="k12" value="1"/>
<Constant key="Parameter_1637" name="k12a" value="1"/>
</ListOfConstants>
<KineticLaw function="Function_51">
<ListOfCallParameters>
<CallParameter functionParameter="FunctionParameter_311">
<SourceParameter reference="Metabolite_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_336">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_334">
<SourceParameter reference="Metabolite_20"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_327">
<SourceParameter reference="Metabolite_21"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_331">
<SourceParameter reference="ModelValue_22"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_332">
<SourceParameter reference="ModelValue_23"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_12" name="v13" reversible="false">
<ListOfSubstrates>
<Substrate metabolite="Metabolite_20" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_9" stoichiometry="1"/>
<Product metabolite="Metabolite_12" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_1638" name="k13" value="1"/>
</ListOfConstants>
<KineticLaw function="Function_52">
<ListOfCallParameters>
<CallParameter functionParameter="FunctionParameter_317">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_333">
<SourceParameter reference="Metabolite_20"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_337">
<SourceParameter reference="ModelValue_24"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_13" name="v14" reversible="true">
<ListOfSubstrates>
<Substrate metabolite="Metabolite_12" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_14" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_1639" name="k14" value="1"/>
<Constant key="Parameter_1640" name="k14a" value="1"/>
</ListOfConstants>
<KineticLaw function="Function_53">
<ListOfCallParameters>
<CallParameter functionParameter="FunctionParameter_343">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_341">
<SourceParameter reference="Metabolite_14"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_335">
<SourceParameter reference="Metabolite_12"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_329">
<SourceParameter reference="ModelValue_25"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_339">
<SourceParameter reference="ModelValue_26"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_14" name="v15" reversible="true">
<ListOfSubstrates>
<Substrate metabolite="Metabolite_14" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_11" stoichiometry="1"/>
<Product metabolite="Metabolite_3" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_1643" name="k15" value="1"/>
<Constant key="Parameter_1642" name="k15a" value="1"/>
</ListOfConstants>
<KineticLaw function="Function_54">
<ListOfCallParameters>
<CallParameter functionParameter="FunctionParameter_350">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_346">
<SourceParameter reference="Metabolite_3"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_340">
<SourceParameter reference="Metabolite_14"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_348">
<SourceParameter reference="Metabolite_11"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_344">
<SourceParameter reference="ModelValue_27"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_323">
<SourceParameter reference="ModelValue_28"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_15" name="v16" reversible="true">
<ListOfSubstrates>
<Substrate metabolite="Metabolite_2" stoichiometry="1"/>
<Substrate metabolite="Metabolite_12" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_23" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_1644" name="k16" value="1"/>
<Constant key="Parameter_1641" name="k16a" value="1"/>
</ListOfConstants>
<KineticLaw function="Function_55">
<ListOfCallParameters>
<CallParameter functionParameter="FunctionParameter_338">
<SourceParameter reference="Metabolite_2"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_356">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_347">
<SourceParameter reference="Metabolite_12"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_354">
<SourceParameter reference="Metabolite_23"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_351">
<SourceParameter reference="ModelValue_29"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_352">
<SourceParameter reference="ModelValue_30"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_16" name="v17" reversible="true">
<ListOfSubstrates>
<Substrate metabolite="Metabolite_11" stoichiometry="1"/>
<Substrate metabolite="Metabolite_12" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_17" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_1645" name="k17" value="1"/>
<Constant key="Parameter_1646" name="k17a" value="1"/>
</ListOfConstants>
<KineticLaw function="Function_56">
<ListOfCallParameters>
<CallParameter functionParameter="FunctionParameter_362">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_345">
<SourceParameter reference="Metabolite_11"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_353">
<SourceParameter reference="Metabolite_12"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_360">
<SourceParameter reference="Metabolite_17"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_357">
<SourceParameter reference="ModelValue_31"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_358">
<SourceParameter reference="ModelValue_32"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_17" name="v19" reversible="true">
<MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Reaction_17">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2013-03-26T10:56:16Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</MiriamAnnotation>
<ListOfSubstrates>
<Substrate metabolite="Metabolite_1" stoichiometry="1"/>
<Substrate metabolite="Metabolite_3" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_6" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_1647" name="k19" value="1"/>
<Constant key="Parameter_1648" name="k19a" value="1381.41"/>
</ListOfConstants>
<KineticLaw function="Function_57">
<ListOfCallParameters>
<CallParameter functionParameter="FunctionParameter_342">
<SourceParameter reference="Metabolite_1"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_368">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_359">
<SourceParameter reference="Metabolite_3"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_366">
<SourceParameter reference="Metabolite_6"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_363">
<SourceParameter reference="ModelValue_33"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_364">
<SourceParameter reference="ModelValue_34"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_18" name="v20" reversible="true">
<ListOfSubstrates>
<Substrate metabolite="Metabolite_0" stoichiometry="1"/>
<Substrate metabolite="Metabolite_6" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_25" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_1649" name="k20" value="1"/>
<Constant key="Parameter_1650" name="k20a" value="1"/>
</ListOfConstants>
<KineticLaw function="Function_58">
<ListOfCallParameters>
<CallParameter functionParameter="FunctionParameter_349">
<SourceParameter reference="Metabolite_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_374">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_372">
<SourceParameter reference="Metabolite_25"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_365">
<SourceParameter reference="Metabolite_6"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_369">
<SourceParameter reference="ModelValue_35"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_370">
<SourceParameter reference="ModelValue_36"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_19" name="v21" reversible="true">
<ListOfSubstrates>
<Substrate metabolite="Metabolite_2" stoichiometry="1"/>
<Substrate metabolite="Metabolite_25" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_26" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_1651" name="k21" value="1"/>
<Constant key="Parameter_1652" name="k21a" value="1"/>
</ListOfConstants>
<KineticLaw function="Function_59">
<ListOfCallParameters>
<CallParameter functionParameter="FunctionParameter_355">
<SourceParameter reference="Metabolite_2"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_380">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_378">
<SourceParameter reference="Metabolite_26"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_371">
<SourceParameter reference="Metabolite_25"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_375">
<SourceParameter reference="ModelValue_37"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_376">
<SourceParameter reference="ModelValue_38"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_20" name="v22" reversible="true">
<ListOfSubstrates>
<Substrate metabolite="Metabolite_2" stoichiometry="1"/>
<Substrate metabolite="Metabolite_6" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_16" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_1653" name="k22" value="1"/>
<Constant key="Parameter_1654" name="k22a" value="1"/>
</ListOfConstants>
<KineticLaw function="Function_60">
<ListOfCallParameters>
<CallParameter functionParameter="FunctionParameter_361">
<SourceParameter reference="Metabolite_2"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_386">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_384">
<SourceParameter reference="Metabolite_16"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_377">
<SourceParameter reference="Metabolite_6"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_381">
<SourceParameter reference="ModelValue_39"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_382">
<SourceParameter reference="ModelValue_40"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_21" name="v23" reversible="true">
<ListOfSubstrates>
<Substrate metabolite="Metabolite_16" stoichiometry="1"/>
<Substrate metabolite="Metabolite_0" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_26" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_1655" name="k23" value="1"/>
<Constant key="Parameter_1656" name="k23a" value="1"/>
</ListOfConstants>
<KineticLaw function="Function_61">
<ListOfCallParameters>
<CallParameter functionParameter="FunctionParameter_367">
<SourceParameter reference="Metabolite_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_392">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_390">
<SourceParameter reference="Metabolite_26"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_383">
<SourceParameter reference="Metabolite_16"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_387">
<SourceParameter reference="ModelValue_41"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_388">
<SourceParameter reference="ModelValue_42"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_22" name="v24" reversible="true">
<ListOfSubstrates>
<Substrate metabolite="Metabolite_1" stoichiometry="1"/>
<Substrate metabolite="Metabolite_5" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_25" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_1657" name="k24" value="1"/>
<Constant key="Parameter_1658" name="k24a" value="1"/>
</ListOfConstants>
<KineticLaw function="Function_62">
<ListOfCallParameters>
<CallParameter functionParameter="FunctionParameter_373">
<SourceParameter reference="Metabolite_1"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_398">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_389">
<SourceParameter reference="Metabolite_5"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_396">
<SourceParameter reference="Metabolite_25"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_393">
<SourceParameter reference="ModelValue_43"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_394">
<SourceParameter reference="ModelValue_44"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_23" name="v25" reversible="true">
<ListOfSubstrates>
<Substrate metabolite="Metabolite_1" stoichiometry="1"/>
<Substrate metabolite="Metabolite_7" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_16" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_1659" name="k25" value="1"/>
<Constant key="Parameter_1660" name="k25a" value="1"/>
</ListOfConstants>
<KineticLaw function="Function_63">
<ListOfCallParameters>
<CallParameter functionParameter="FunctionParameter_379">
<SourceParameter reference="Metabolite_1"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_404">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_395">
<SourceParameter reference="Metabolite_7"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_402">
<SourceParameter reference="Metabolite_16"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_399">
<SourceParameter reference="ModelValue_45"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_400">
<SourceParameter reference="ModelValue_46"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_24" name="v26" reversible="true">
<ListOfSubstrates>
<Substrate metabolite="Metabolite_1" stoichiometry="1"/>
<Substrate metabolite="Metabolite_18" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_26" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_1665" name="k26" value="1"/>
<Constant key="Parameter_1664" name="k26a" value="1"/>
</ListOfConstants>
<KineticLaw function="Function_64">
<ListOfCallParameters>
<CallParameter functionParameter="FunctionParameter_385">
<SourceParameter reference="Metabolite_1"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_410">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_401">
<SourceParameter reference="Metabolite_18"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_408">
<SourceParameter reference="Metabolite_26"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_405">
<SourceParameter reference="ModelValue_47"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_406">
<SourceParameter reference="ModelValue_48"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_25" name="v27" reversible="false">
<ListOfSubstrates>
<Substrate metabolite="Metabolite_26" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_4" stoichiometry="1"/>
<Product metabolite="Metabolite_9" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_1663" name="k27" value="1"/>
</ListOfConstants>
<KineticLaw function="Function_65">
<ListOfCallParameters>
<CallParameter functionParameter="FunctionParameter_391">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_407">
<SourceParameter reference="Metabolite_26"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_411">
<SourceParameter reference="ModelValue_49"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_26" name="v28" reversible="true">
<ListOfSubstrates>
<Substrate metabolite="Metabolite_4" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_15" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_1661" name="k28" value="1"/>
<Constant key="Parameter_1662" name="k28a" value="1"/>
</ListOfConstants>
<KineticLaw function="Function_66">
<ListOfCallParameters>
<CallParameter functionParameter="FunctionParameter_417">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_415">
<SourceParameter reference="Metabolite_15"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_409">
<SourceParameter reference="Metabolite_4"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_403">
<SourceParameter reference="ModelValue_50"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_413">
<SourceParameter reference="ModelValue_51"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_27" name="v29" reversible="true">
<ListOfSubstrates>
<Substrate metabolite="Metabolite_15" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_8" stoichiometry="1"/>
<Product metabolite="Metabolite_3" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_1666" name="k29" value="1"/>
<Constant key="Parameter_1667" name="k29a" value="1"/>
</ListOfConstants>
<KineticLaw function="Function_67">
<ListOfCallParameters>
<CallParameter functionParameter="FunctionParameter_424">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_420">
<SourceParameter reference="Metabolite_3"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_414">
<SourceParameter reference="Metabolite_15"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_422">
<SourceParameter reference="Metabolite_8"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_418">
<SourceParameter reference="ModelValue_52"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_397">
<SourceParameter reference="ModelValue_53"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_28" name="v30" reversible="true">
<MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Reaction_28">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2013-03-26T10:58:42Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</MiriamAnnotation>
<ListOfSubstrates>
<Substrate metabolite="Metabolite_4" stoichiometry="1"/>
<Substrate metabolite="Metabolite_2" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_24" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_1670" name="k30" value="264.931"/>
<Constant key="Parameter_1669" name="k30a" value="1706.16"/>
</ListOfConstants>
<KineticLaw function="Function_68">
<ListOfCallParameters>
<CallParameter functionParameter="FunctionParameter_412">
<SourceParameter reference="Metabolite_2"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_430">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_421">
<SourceParameter reference="Metabolite_4"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_428">
<SourceParameter reference="Metabolite_24"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_425">
<SourceParameter reference="ModelValue_54"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_426">
<SourceParameter reference="ModelValue_55"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_29" name="v31" reversible="true">
<MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Reaction_29">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2013-03-26T10:58:42Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</MiriamAnnotation>
<ListOfSubstrates>
<Substrate metabolite="Metabolite_4" stoichiometry="1"/>
<Substrate metabolite="Metabolite_11" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_19" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_1668" name="k31" value="9.54226"/>
<Constant key="Parameter_1671" name="k31a" value="216.98"/>
</ListOfConstants>
<KineticLaw function="Function_69">
<ListOfCallParameters>
<CallParameter functionParameter="FunctionParameter_436">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_419">
<SourceParameter reference="Metabolite_11"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_427">
<SourceParameter reference="Metabolite_4"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_434">
<SourceParameter reference="Metabolite_19"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_431">
<SourceParameter reference="ModelValue_56"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_432">
<SourceParameter reference="ModelValue_57"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
<Reaction key="Reaction_30" name="v32" reversible="false">
<MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Reaction_30">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2013-03-26T10:58:43Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</MiriamAnnotation>
<ListOfSubstrates>
<Substrate metabolite="Metabolite_9" stoichiometry="1"/>
</ListOfSubstrates>
<ListOfProducts>
<Product metabolite="Metabolite_10" stoichiometry="1"/>
</ListOfProducts>
<ListOfConstants>
<Constant key="Parameter_1672" name="k32" value="4852.33"/>
</ListOfConstants>
<KineticLaw function="Function_70">
<ListOfCallParameters>
<CallParameter functionParameter="FunctionParameter_416">
<SourceParameter reference="Compartment_0"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_433">
<SourceParameter reference="Metabolite_9"/>
</CallParameter>
<CallParameter functionParameter="FunctionParameter_437">
<SourceParameter reference="ModelValue_58"/>
</CallParameter>
</ListOfCallParameters>
</KineticLaw>
</Reaction>
</ListOfReactions>
<StateTemplate>
<StateTemplateVariable objectReference="Model_0"/>
<StateTemplateVariable objectReference="Metabolite_3"/>
<StateTemplateVariable objectReference="Metabolite_8"/>
<StateTemplateVariable objectReference="Metabolite_4"/>
<StateTemplateVariable objectReference="Metabolite_12"/>
<StateTemplateVariable objectReference="Metabolite_18"/>
<StateTemplateVariable objectReference="Metabolite_26"/>
<StateTemplateVariable objectReference="Metabolite_20"/>
<StateTemplateVariable objectReference="Metabolite_7"/>
<StateTemplateVariable objectReference="Metabolite_6"/>
<StateTemplateVariable objectReference="Metabolite_13"/>
<StateTemplateVariable objectReference="Metabolite_5"/>
<StateTemplateVariable objectReference="Metabolite_9"/>
<StateTemplateVariable objectReference="Metabolite_21"/>
<StateTemplateVariable objectReference="Metabolite_25"/>
<StateTemplateVariable objectReference="Metabolite_14"/>
<StateTemplateVariable objectReference="Metabolite_15"/>
<StateTemplateVariable objectReference="Metabolite_22"/>
<StateTemplateVariable objectReference="Metabolite_24"/>
<StateTemplateVariable objectReference="Metabolite_17"/>
<StateTemplateVariable objectReference="Metabolite_16"/>
<StateTemplateVariable objectReference="Metabolite_23"/>
<StateTemplateVariable objectReference="Metabolite_19"/>
<StateTemplateVariable objectReference="ModelValue_0"/>
<StateTemplateVariable objectReference="ModelValue_10"/>
<StateTemplateVariable objectReference="ModelValue_12"/>
<StateTemplateVariable objectReference="ModelValue_15"/>
<StateTemplateVariable objectReference="ModelValue_20"/>
<StateTemplateVariable objectReference="ModelValue_33"/>
<StateTemplateVariable objectReference="ModelValue_35"/>
<StateTemplateVariable objectReference="ModelValue_43"/>
<StateTemplateVariable objectReference="ModelValue_45"/>
<StateTemplateVariable objectReference="Metabolite_0"/>
<StateTemplateVariable objectReference="Metabolite_1"/>
<StateTemplateVariable objectReference="Metabolite_2"/>
<StateTemplateVariable objectReference="Metabolite_10"/>
<StateTemplateVariable objectReference="Metabolite_11"/>
<StateTemplateVariable objectReference="Compartment_0"/>
<StateTemplateVariable objectReference="ModelValue_1"/>
<StateTemplateVariable objectReference="ModelValue_2"/>
<StateTemplateVariable objectReference="ModelValue_3"/>
<StateTemplateVariable objectReference="ModelValue_4"/>
<StateTemplateVariable objectReference="ModelValue_5"/>
<StateTemplateVariable objectReference="ModelValue_6"/>
<StateTemplateVariable objectReference="ModelValue_7"/>
<StateTemplateVariable objectReference="ModelValue_8"/>
<StateTemplateVariable objectReference="ModelValue_9"/>
<StateTemplateVariable objectReference="ModelValue_11"/>
<StateTemplateVariable objectReference="ModelValue_13"/>
<StateTemplateVariable objectReference="ModelValue_14"/>
<StateTemplateVariable objectReference="ModelValue_16"/>
<StateTemplateVariable objectReference="ModelValue_17"/>
<StateTemplateVariable objectReference="ModelValue_18"/>
<StateTemplateVariable objectReference="ModelValue_19"/>
<StateTemplateVariable objectReference="ModelValue_21"/>
<StateTemplateVariable objectReference="ModelValue_22"/>
<StateTemplateVariable objectReference="ModelValue_23"/>
<StateTemplateVariable objectReference="ModelValue_24"/>
<StateTemplateVariable objectReference="ModelValue_25"/>
<StateTemplateVariable objectReference="ModelValue_26"/>
<StateTemplateVariable objectReference="ModelValue_27"/>
<StateTemplateVariable objectReference="ModelValue_28"/>
<StateTemplateVariable objectReference="ModelValue_29"/>
<StateTemplateVariable objectReference="ModelValue_30"/>
<StateTemplateVariable objectReference="ModelValue_31"/>
<StateTemplateVariable objectReference="ModelValue_32"/>
<StateTemplateVariable objectReference="ModelValue_34"/>
<StateTemplateVariable objectReference="ModelValue_36"/>
<StateTemplateVariable objectReference="ModelValue_37"/>
<StateTemplateVariable objectReference="ModelValue_38"/>
<StateTemplateVariable objectReference="ModelValue_39"/>
<StateTemplateVariable objectReference="ModelValue_40"/>
<StateTemplateVariable objectReference="ModelValue_41"/>
<StateTemplateVariable objectReference="ModelValue_42"/>
<StateTemplateVariable objectReference="ModelValue_44"/>
<StateTemplateVariable objectReference="ModelValue_46"/>
<StateTemplateVariable objectReference="ModelValue_47"/>
<StateTemplateVariable objectReference="ModelValue_48"/>
<StateTemplateVariable objectReference="ModelValue_49"/>
<StateTemplateVariable objectReference="ModelValue_50"/>
<StateTemplateVariable objectReference="ModelValue_51"/>
<StateTemplateVariable objectReference="ModelValue_52"/>
<StateTemplateVariable objectReference="ModelValue_53"/>
<StateTemplateVariable objectReference="ModelValue_54"/>
<StateTemplateVariable objectReference="ModelValue_55"/>
<StateTemplateVariable objectReference="ModelValue_56"/>
<StateTemplateVariable objectReference="ModelValue_57"/>
<StateTemplateVariable objectReference="ModelValue_58"/>
</StateTemplate>
<InitialState type="initialState">
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</InitialState>
</Model>
<ListOfTasks>
<Task key="Task_12" name="Steady-State" type="steadyState" scheduled="false" updateModel="false">
<Report reference="Report_8" target="" append="1" confirmOverwrite="1"/>
<Problem>
<Parameter name="JacobianRequested" type="bool" value="1"/>
<Parameter name="StabilityAnalysisRequested" type="bool" value="1"/>
</Problem>
<Method name="Enhanced Newton" type="EnhancedNewton">
<Parameter name="Resolution" type="unsignedFloat" value="1e-009"/>
<Parameter name="Derivation Factor" type="unsignedFloat" value="0.001"/>
<Parameter name="Use Newton" type="bool" value="1"/>
<Parameter name="Use Integration" type="bool" value="1"/>
<Parameter name="Use Back Integration" type="bool" value="1"/>
<Parameter name="Accept Negative Concentrations" type="bool" value="0"/>
<Parameter name="Iteration Limit" type="unsignedInteger" value="50"/>
<Parameter name="Maximum duration for forward integration" type="unsignedFloat" value="1000000000"/>
<Parameter name="Maximum duration for backward integration" type="unsignedFloat" value="1000000"/>
</Method>
</Task>
<Task key="Task_11" name="Time-Course" type="timeCourse" scheduled="false" updateModel="false">
<Problem>
<Parameter name="StepNumber" type="unsignedInteger" value="100"/>
<Parameter name="StepSize" type="float" value="0.01"/>
<Parameter name="Duration" type="float" value="1"/>
<Parameter name="TimeSeriesRequested" type="bool" value="1"/>
<Parameter name="OutputStartTime" type="float" value="0"/>
<Parameter name="Output Event" type="bool" value="0"/>
</Problem>
<Method name="Deterministic (LSODA)" type="Deterministic(LSODA)">
<Parameter name="Integrate Reduced Model" type="bool" value="0"/>
<Parameter name="Relative Tolerance" type="unsignedFloat" value="1e-006"/>
<Parameter name="Absolute Tolerance" type="unsignedFloat" value="1e-012"/>
<Parameter name="Max Internal Steps" type="unsignedInteger" value="10000"/>
</Method>
</Task>
<Task key="Task_10" name="Scan" type="scan" scheduled="false" updateModel="false">
<Problem>
<Parameter name="Subtask" type="unsignedInteger" value="0"/>
<ParameterGroup name="ScanItems">
<ParameterGroup name="ScanItem">
<Parameter name="Maximum" type="float" value="3000"/>
<Parameter name="Minimum" type="float" value="0"/>
<Parameter name="Number of steps" type="unsignedInteger" value="100"/>
<Parameter name="Object" type="cn" value="CN=Root,Model=TryS_119,Vector=Compartments[Cell],Vector=Metabolites[B],Reference=InitialConcentration"/>
<Parameter name="Type" type="unsignedInteger" value="1"/>
<Parameter name="log" type="bool" value="0"/>
</ParameterGroup>
</ParameterGroup>
<Parameter name="Output in subtask" type="bool" value="0"/>
<Parameter name="Adjust initial conditions" type="bool" value="0"/>
</Problem>
<Method name="Scan Framework" type="ScanFramework">
</Method>
</Task>
<Task key="Task_9" name="Elementary Flux Modes" type="fluxMode" scheduled="false" updateModel="false">
<Report reference="Report_7" target="" append="1" confirmOverwrite="1"/>
<Problem>
</Problem>
<Method name="EFM Algorithm" type="EFMAlgorithm">
</Method>
</Task>
<Task key="Task_8" name="Optimization" type="optimization" scheduled="false" updateModel="false">
<Report reference="Report_6" target="" append="1" confirmOverwrite="1"/>
<Problem>
<Parameter name="Subtask" type="cn" value="CN=Root,Vector=TaskList[Steady-State]"/>
<ParameterText name="ObjectiveExpression" type="expression">
</ParameterText>
<Parameter name="Maximize" type="bool" value="0"/>
<Parameter name="Randomize Start Values" type="bool" value="0"/>
<Parameter name="Calculate Statistics" type="bool" value="1"/>
<ParameterGroup name="OptimizationItemList">
</ParameterGroup>
<ParameterGroup name="OptimizationConstraintList">
</ParameterGroup>
</Problem>
<Method name="Random Search" type="RandomSearch">
<Parameter name="Number of Iterations" type="unsignedInteger" value="100000"/>
<Parameter name="Random Number Generator" type="unsignedInteger" value="1"/>
<Parameter name="Seed" type="unsignedInteger" value="0"/>
</Method>
</Task>
<Task key="Task_7" name="Parameter Estimation" type="parameterFitting" scheduled="false" updateModel="false">
<Report reference="Report_5" target="" append="1" confirmOverwrite="1"/>
<Problem>
<Parameter name="Maximize" type="bool" value="0"/>
<Parameter name="Randomize Start Values" type="bool" value="0"/>
<Parameter name="Calculate Statistics" type="bool" value="1"/>
<ParameterGroup name="OptimizationItemList">
<ParameterGroup name="FitItem">
<ParameterGroup name="Affected Cross Validation Experiments">
</ParameterGroup>
<ParameterGroup name="Affected Experiments">
</ParameterGroup>
<Parameter name="LowerBound" type="cn" value="1e-10"/>
<Parameter name="ObjectCN" type="cn" value="CN=Root,Model=TryS_119,Vector=Values[k19a],Reference=InitialValue"/>
<Parameter name="StartValue" type="float" value="868.3235560175809"/>
<Parameter name="UpperBound" type="cn" value="inf"/>
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<ParameterGroup name="FitItem">
<ParameterGroup name="Affected Cross Validation Experiments">
</ParameterGroup>
<ParameterGroup name="Affected Experiments">
</ParameterGroup>
<Parameter name="LowerBound" type="cn" value="1e-10"/>
<Parameter name="ObjectCN" type="cn" value="CN=Root,Model=TryS_119,Vector=Values[k20a],Reference=InitialValue"/>
<Parameter name="StartValue" type="float" value="1e-010"/>
<Parameter name="UpperBound" type="cn" value="inf"/>
</ParameterGroup>
<ParameterGroup name="FitItem">
<ParameterGroup name="Affected Cross Validation Experiments">
</ParameterGroup>
<ParameterGroup name="Affected Experiments">
</ParameterGroup>
<Parameter name="LowerBound" type="cn" value="1e-10"/>
<Parameter name="ObjectCN" type="cn" value="CN=Root,Model=TryS_119,Vector=Values[k21],Reference=InitialValue"/>
<Parameter name="StartValue" type="float" value="94.60314178235619"/>
<Parameter name="UpperBound" type="cn" value="inf"/>
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<ParameterGroup name="FitItem">
<ParameterGroup name="Affected Cross Validation Experiments">
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<ParameterGroup name="Affected Experiments">
</ParameterGroup>
<Parameter name="LowerBound" type="cn" value="1e-10"/>
<Parameter name="ObjectCN" type="cn" value="CN=Root,Model=TryS_119,Vector=Values[k21a],Reference=InitialValue"/>
<Parameter name="StartValue" type="float" value="56632.71736790135"/>
<Parameter name="UpperBound" type="cn" value="inf"/>
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<ParameterGroup name="FitItem">
<ParameterGroup name="Affected Cross Validation Experiments">
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<ParameterGroup name="Affected Experiments">
</ParameterGroup>
<Parameter name="LowerBound" type="cn" value="1e-10"/>
<Parameter name="ObjectCN" type="cn" value="CN=Root,Model=TryS_119,Vector=Values[k22],Reference=InitialValue"/>
<Parameter name="StartValue" type="float" value="897.7372926606398"/>
<Parameter name="UpperBound" type="cn" value="inf"/>
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<ParameterGroup name="FitItem">
<ParameterGroup name="Affected Cross Validation Experiments">
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<ParameterGroup name="Affected Experiments">
</ParameterGroup>
<Parameter name="LowerBound" type="cn" value="1e-10"/>
<Parameter name="ObjectCN" type="cn" value="CN=Root,Model=TryS_119,Vector=Values[k22a],Reference=InitialValue"/>
<Parameter name="StartValue" type="float" value="26.80024184881917"/>
<Parameter name="UpperBound" type="cn" value="inf"/>
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<ParameterGroup name="FitItem">
<ParameterGroup name="Affected Cross Validation Experiments">
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<ParameterGroup name="Affected Experiments">
</ParameterGroup>
<Parameter name="LowerBound" type="cn" value="1e-10"/>
<Parameter name="ObjectCN" type="cn" value="CN=Root,Model=TryS_119,Vector=Values[k23],Reference=InitialValue"/>
<Parameter name="StartValue" type="float" value="1e-010"/>
<Parameter name="UpperBound" type="cn" value="inf"/>
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<ParameterGroup name="FitItem">
<ParameterGroup name="Affected Cross Validation Experiments">
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<ParameterGroup name="Affected Experiments">
</ParameterGroup>
<Parameter name="LowerBound" type="cn" value="1e-10"/>
<Parameter name="ObjectCN" type="cn" value="CN=Root,Model=TryS_119,Vector=Values[k23a],Reference=InitialValue"/>
<Parameter name="StartValue" type="float" value="1e-010"/>
<Parameter name="UpperBound" type="cn" value="inf"/>
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<ParameterGroup name="FitItem">
<ParameterGroup name="Affected Cross Validation Experiments">
</ParameterGroup>
<ParameterGroup name="Affected Experiments">
</ParameterGroup>
<Parameter name="LowerBound" type="cn" value="1e-10"/>
<Parameter name="ObjectCN" type="cn" value="CN=Root,Model=TryS_119,Vector=Values[k24a],Reference=InitialValue"/>
<Parameter name="StartValue" type="float" value="13678.37882701691"/>
<Parameter name="UpperBound" type="cn" value="inf"/>
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<ParameterGroup name="FitItem">
<ParameterGroup name="Affected Cross Validation Experiments">
</ParameterGroup>
<ParameterGroup name="Affected Experiments">
</ParameterGroup>
<Parameter name="LowerBound" type="cn" value="1e-10"/>
<Parameter name="ObjectCN" type="cn" value="CN=Root,Model=TryS_119,Vector=Values[k25a],Reference=InitialValue"/>
<Parameter name="StartValue" type="float" value="1e-010"/>
<Parameter name="UpperBound" type="cn" value="inf"/>
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<ParameterGroup name="FitItem">
<ParameterGroup name="Affected Cross Validation Experiments">
</ParameterGroup>
<ParameterGroup name="Affected Experiments">
</ParameterGroup>
<Parameter name="LowerBound" type="cn" value="1e-10"/>
<Parameter name="ObjectCN" type="cn" value="CN=Root,Model=TryS_119,Vector=Values[k26],Reference=InitialValue"/>
<Parameter name="StartValue" type="float" value="0.04749572035088576"/>
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<ParameterGroup name="FitItem">
<ParameterGroup name="Affected Cross Validation Experiments">
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<ParameterGroup name="Affected Experiments">
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<Parameter name="LowerBound" type="cn" value="1e-10"/>
<Parameter name="ObjectCN" type="cn" value="CN=Root,Model=TryS_119,Vector=Values[k26a],Reference=InitialValue"/>
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<ParameterGroup name="FitItem">
<ParameterGroup name="Affected Cross Validation Experiments">
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<ParameterGroup name="Affected Experiments">
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<Parameter name="LowerBound" type="cn" value="1e-10"/>
<Parameter name="ObjectCN" type="cn" value="CN=Root,Model=TryS_119,Vector=Values[k27],Reference=InitialValue"/>
<Parameter name="StartValue" type="float" value="15.17703303207865"/>
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<ParameterGroup name="FitItem">
<ParameterGroup name="Affected Cross Validation Experiments">
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<ParameterGroup name="Affected Experiments">
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<Parameter name="LowerBound" type="cn" value="1e-10"/>
<Parameter name="ObjectCN" type="cn" value="CN=Root,Model=TryS_119,Vector=Values[k28],Reference=InitialValue"/>
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<ParameterGroup name="FitItem">
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<ParameterGroup name="Affected Experiments">
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<Parameter name="LowerBound" type="cn" value="1e-10"/>
<Parameter name="ObjectCN" type="cn" value="CN=Root,Model=TryS_119,Vector=Values[k28a],Reference=InitialValue"/>
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<ParameterGroup name="FitItem">
<ParameterGroup name="Affected Cross Validation Experiments">
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<ParameterGroup name="Affected Experiments">
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<Parameter name="LowerBound" type="cn" value="1e-10"/>
<Parameter name="ObjectCN" type="cn" value="CN=Root,Model=TryS_119,Vector=Values[k29],Reference=InitialValue"/>
<Parameter name="StartValue" type="float" value="30247.77369507031"/>
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<ParameterGroup name="FitItem">
<ParameterGroup name="Affected Cross Validation Experiments">
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<ParameterGroup name="Affected Experiments">
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<Parameter name="LowerBound" type="cn" value="1e-10"/>
<Parameter name="ObjectCN" type="cn" value="CN=Root,Model=TryS_119,Vector=Values[k29a],Reference=InitialValue"/>
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<ParameterGroup name="FitItem">
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<ParameterGroup name="Affected Experiments">
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<Parameter name="LowerBound" type="cn" value="1e-10"/>
<Parameter name="ObjectCN" type="cn" value="CN=Root,Model=TryS_119,Vector=Values[k30],Reference=InitialValue"/>
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<ParameterGroup name="FitItem">
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<ParameterGroup name="Affected Experiments">
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<Parameter name="LowerBound" type="cn" value="1e-10"/>
<Parameter name="ObjectCN" type="cn" value="CN=Root,Model=TryS_119,Vector=Values[k30a],Reference=InitialValue"/>
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<ParameterGroup name="Affected Experiments">
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<Parameter name="LowerBound" type="cn" value="1e-10"/>
<Parameter name="ObjectCN" type="cn" value="CN=Root,Model=TryS_119,Vector=Values[k31],Reference=InitialValue"/>
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<ParameterGroup name="Affected Experiments">
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<Parameter name="LowerBound" type="cn" value="1e-10"/>
<Parameter name="ObjectCN" type="cn" value="CN=Root,Model=TryS_119,Vector=Values[k31a],Reference=InitialValue"/>
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<ParameterGroup name="Affected Experiments">
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<Parameter name="LowerBound" type="cn" value="1e-10"/>
<Parameter name="ObjectCN" type="cn" value="CN=Root,Model=TryS_119,Vector=Values[k32],Reference=InitialValue"/>
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<Parameter name="Role" type="unsignedInteger" value="0"/>
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<ParameterGroup name="23">
<Parameter name="Role" type="unsignedInteger" value="0"/>
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<ParameterGroup name="24">
<Parameter name="Object CN" type="cn" value="CN=Root,Model=TryS_119,Vector=Reactions[v32],Reference=Flux"/>
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<Parameter name="Separator" type="string" value=";"/>
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<ParameterGroup name="Experiment_1">
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<Parameter name="File Name" type="file" value="../data/Sysmo_trypanothionesystem/data_Alejandro/cleaned_up_data/umol/20120910_TSH2 Inhibition_extradatapoints_Spdonly_umol.csv"/>
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</ParameterGroup>
<ParameterGroup name="10">
<Parameter name="Object CN" type="cn" value="CN=Root,Model=TryS_119,Vector=Compartments[Cell],Vector=Metabolites[R],Reference=InitialConcentration"/>
<Parameter name="Role" type="unsignedInteger" value="1"/>
</ParameterGroup>
<ParameterGroup name="11">
<Parameter name="Object CN" type="cn" value="CN=Root,Model=TryS_119,Vector=Compartments[Cell],Vector=Metabolites[Q],Reference=InitialConcentration"/>
<Parameter name="Role" type="unsignedInteger" value="1"/>
</ParameterGroup>
<ParameterGroup name="12">
<Parameter name="Object CN" type="cn" value="CN=Root,Model=TryS_119,Vector=Compartments[Cell],Vector=Metabolites[C],Reference=InitialConcentration"/>
<Parameter name="Role" type="unsignedInteger" value="1"/>
</ParameterGroup>
<ParameterGroup name="13">
<Parameter name="Object CN" type="cn" value="CN=Root,Model=TryS_119,Vector=Compartments[Cell],Vector=Metabolites[A],Reference=InitialConcentration"/>
<Parameter name="Role" type="unsignedInteger" value="1"/>
</ParameterGroup>
<ParameterGroup name="14">
<Parameter name="Object CN" type="cn" value="CN=Root,Model=TryS_119,Vector=Compartments[Cell],Vector=Metabolites[B],Reference=InitialConcentration"/>
<Parameter name="Role" type="unsignedInteger" value="1"/>
</ParameterGroup>
<ParameterGroup name="15">
<Parameter name="Role" type="unsignedInteger" value="0"/>
</ParameterGroup>
<ParameterGroup name="16">
<Parameter name="Role" type="unsignedInteger" value="0"/>
</ParameterGroup>
<ParameterGroup name="17">
<Parameter name="Role" type="unsignedInteger" value="0"/>
</ParameterGroup>
<ParameterGroup name="18">
<Parameter name="Role" type="unsignedInteger" value="0"/>
</ParameterGroup>
<ParameterGroup name="19">
<Parameter name="Role" type="unsignedInteger" value="0"/>
</ParameterGroup>
<ParameterGroup name="2">
<Parameter name="Role" type="unsignedInteger" value="0"/>
</ParameterGroup>
<ParameterGroup name="20">
<Parameter name="Role" type="unsignedInteger" value="0"/>
</ParameterGroup>
<ParameterGroup name="21">
<Parameter name="Role" type="unsignedInteger" value="0"/>
</ParameterGroup>
<ParameterGroup name="22">
<Parameter name="Role" type="unsignedInteger" value="0"/>
</ParameterGroup>
<ParameterGroup name="23">
<Parameter name="Role" type="unsignedInteger" value="0"/>
</ParameterGroup>
<ParameterGroup name="24">
<Parameter name="Object CN" type="cn" value="CN=Root,Model=TryS_119,Vector=Reactions[v32],Reference=Flux"/>
<Parameter name="Role" type="unsignedInteger" value="2"/>
</ParameterGroup>
<ParameterGroup name="25">
<Parameter name="Role" type="unsignedInteger" value="0"/>
</ParameterGroup>
<ParameterGroup name="3">
<Parameter name="Role" type="unsignedInteger" value="0"/>
</ParameterGroup>
<ParameterGroup name="4">
<Parameter name="Role" type="unsignedInteger" value="0"/>
</ParameterGroup>
<ParameterGroup name="5">
<Parameter name="Role" type="unsignedInteger" value="0"/>
</ParameterGroup>
<ParameterGroup name="6">
<Parameter name="Role" type="unsignedInteger" value="0"/>
</ParameterGroup>
<ParameterGroup name="7">
<Parameter name="Role" type="unsignedInteger" value="0"/>
</ParameterGroup>
<ParameterGroup name="8">
<Parameter name="Role" type="unsignedInteger" value="0"/>
</ParameterGroup>
<ParameterGroup name="9">
<Parameter name="Role" type="unsignedInteger" value="0"/>
</ParameterGroup>
</ParameterGroup>
<Parameter name="Row containing Names" type="unsignedInteger" value="1"/>
<Parameter name="Separator" type="string" value=";"/>
<Parameter name="Weight Method" type="unsignedInteger" value="1"/>
</ParameterGroup>
</ParameterGroup>
<ParameterGroup name="Validation Set">
<Parameter name="Threshold" type="unsignedInteger" value="5"/>
<Parameter name="Weight" type="unsignedFloat" value="1"/>
</ParameterGroup>
</Problem>
<Method name="Evolutionary Programming" type="EvolutionaryProgram">
<Parameter name="Number of Generations" type="unsignedInteger" value="200"/>
<Parameter name="Population Size" type="unsignedInteger" value="20"/>
<Parameter name="Random Number Generator" type="unsignedInteger" value="1"/>
<Parameter name="Seed" type="unsignedInteger" value="0"/>
</Method>
</Task>
<Task key="Task_6" name="Metabolic Control Analysis" type="metabolicControlAnalysis" scheduled="false" updateModel="false">
<Report reference="Report_4" target="" append="1" confirmOverwrite="1"/>
<Problem>
<Parameter name="Steady-State" type="key" value="Task_12"/>
</Problem>
<Method name="MCA Method (Reder)" type="MCAMethod(Reder)">
<Parameter name="Modulation Factor" type="unsignedFloat" value="1e-009"/>
</Method>
</Task>
<Task key="Task_5" name="Lyapunov Exponents" type="lyapunovExponents" scheduled="false" updateModel="false">
<Report reference="Report_3" target="" append="1" confirmOverwrite="1"/>
<Problem>
<Parameter name="ExponentNumber" type="unsignedInteger" value="3"/>
<Parameter name="DivergenceRequested" type="bool" value="1"/>
<Parameter name="TransientTime" type="float" value="0"/>
</Problem>
<Method name="Wolf Method" type="WolfMethod">
<Parameter name="Orthonormalization Interval" type="unsignedFloat" value="1"/>
<Parameter name="Overall time" type="unsignedFloat" value="1000"/>
<Parameter name="Relative Tolerance" type="unsignedFloat" value="1e-006"/>
<Parameter name="Absolute Tolerance" type="unsignedFloat" value="1e-012"/>
<Parameter name="Max Internal Steps" type="unsignedInteger" value="10000"/>
</Method>
</Task>
<Task key="Task_4" name="Time Scale Separation Analysis" type="timeScaleSeparationAnalysis" scheduled="false" updateModel="false">
<Report reference="Report_2" target="" append="1" confirmOverwrite="1"/>
<Problem>
<Parameter name="StepNumber" type="unsignedInteger" value="100"/>
<Parameter name="StepSize" type="float" value="0.01"/>
<Parameter name="Duration" type="float" value="1"/>
<Parameter name="TimeSeriesRequested" type="bool" value="1"/>
<Parameter name="OutputStartTime" type="float" value="0"/>
</Problem>
<Method name="ILDM (LSODA,Deuflhard)" type="TimeScaleSeparation(ILDM,Deuflhard)">
<Parameter name="Deuflhard Tolerance" type="unsignedFloat" value="1e-006"/>
</Method>
</Task>
<Task key="Task_3" name="Sensitivities" type="sensitivities" scheduled="false" updateModel="false">
<Report reference="Report_1" target="" append="1" confirmOverwrite="1"/>
<Problem>
<Parameter name="SubtaskType" type="unsignedInteger" value="1"/>
<ParameterGroup name="TargetFunctions">
<Parameter name="SingleObject" type="cn" value=""/>
<Parameter name="ObjectListType" type="unsignedInteger" value="7"/>
</ParameterGroup>
<ParameterGroup name="ListOfVariables">
<ParameterGroup name="Variables">
<Parameter name="SingleObject" type="cn" value=""/>
<Parameter name="ObjectListType" type="unsignedInteger" value="41"/>
</ParameterGroup>
</ParameterGroup>
</Problem>
<Method name="Sensitivities Method" type="SensitivitiesMethod">
<Parameter name="Delta factor" type="unsignedFloat" value="0.001"/>
<Parameter name="Delta minimum" type="unsignedFloat" value="1e-012"/>
</Method>
</Task>
<Task key="Task_2" name="Moieties" type="moieties" scheduled="false" updateModel="false">
<Problem>
</Problem>
<Method name="Householder Reduction" type="Householder">
</Method>
</Task>
<Task key="Task_1" name="Cross Section" type="crosssection" scheduled="false" updateModel="false">
<Problem>
<Parameter name="StepNumber" type="unsignedInteger" value="100"/>
<Parameter name="StepSize" type="float" value="0.01"/>
<Parameter name="Duration" type="float" value="1"/>
<Parameter name="TimeSeriesRequested" type="bool" value="1"/>
<Parameter name="OutputStartTime" type="float" value="0"/>
<Parameter name="Output Event" type="bool" value="0"/>
<Parameter name="LimitCrossings" type="bool" value="0"/>
<Parameter name="NumCrossingsLimit" type="unsignedInteger" value="0"/>
<Parameter name="LimitOutTime" type="bool" value="0"/>
<Parameter name="LimitOutCrossings" type="bool" value="0"/>
<Parameter name="PositiveDirection" type="bool" value="1"/>
<Parameter name="NumOutCrossingsLimit" type="unsignedInteger" value="0"/>
<Parameter name="LimitUntilConvergence" type="bool" value="0"/>
<Parameter name="ConvergenceTolerance" type="float" value="1e-006"/>
<Parameter name="Threshold" type="float" value="0"/>
<Parameter name="DelayOutputUntilConvergence" type="bool" value="0"/>
<Parameter name="OutputConvergenceTolerance" type="float" value="1e-006"/>
<ParameterText name="TriggerExpression" type="expression">
</ParameterText>
<Parameter name="SingleVariable" type="cn" value=""/>
</Problem>
<Method name="Deterministic (LSODA)" type="Deterministic(LSODA)">
<Parameter name="Integrate Reduced Model" type="bool" value="0"/>
<Parameter name="Relative Tolerance" type="unsignedFloat" value="1e-006"/>
<Parameter name="Absolute Tolerance" type="unsignedFloat" value="1e-012"/>
<Parameter name="Max Internal Steps" type="unsignedInteger" value="10000"/>
</Method>
</Task>
<Task key="Task_13" name="Linear Noise Approximation" type="linearNoiseApproximation" scheduled="false" updateModel="false">
<Report reference="Report_0" target="" append="1" confirmOverwrite="1"/>
<Problem>
<Parameter name="Steady-State" type="key" value="Task_12"/>
</Problem>
<Method name="Linear Noise Approximation" type="LinearNoiseApproximation">
</Method>
</Task>
</ListOfTasks>
<ListOfReports>
<Report key="Report_8" name="Steady-State" taskType="steadyState" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Footer>
<Object cn="CN=Root,Vector=TaskList[Steady-State]"/>
</Footer>
</Report>
<Report key="Report_7" name="Elementary Flux Modes" taskType="fluxMode" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Footer>
<Object cn="CN=Root,Vector=TaskList[Elementary Flux Modes],Object=Result"/>
</Footer>
</Report>
<Report key="Report_6" name="Optimization" taskType="optimization" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Header>
<Object cn="CN=Root,Vector=TaskList[Optimization],Object=Description"/>
<Object cn="String=\[Function Evaluations\]"/>
<Object cn="Separator=	"/>
<Object cn="String=\[Best Value\]"/>
<Object cn="Separator=	"/>
<Object cn="String=\[Best Parameters\]"/>
</Header>
<Body>
<Object cn="CN=Root,Vector=TaskList[Optimization],Problem=Optimization,Reference=Function Evaluations"/>
<Object cn="Separator=	"/>
<Object cn="CN=Root,Vector=TaskList[Optimization],Problem=Optimization,Reference=Best Value"/>
<Object cn="Separator=	"/>
<Object cn="CN=Root,Vector=TaskList[Optimization],Problem=Optimization,Reference=Best Parameters"/>
</Body>
<Footer>
<Object cn="String=
"/>
<Object cn="CN=Root,Vector=TaskList[Optimization],Object=Result"/>
</Footer>
</Report>
<Report key="Report_5" name="Parameter Estimation" taskType="parameterFitting" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Header>
<Object cn="CN=Root,Vector=TaskList[Parameter Estimation],Object=Description"/>
<Object cn="String=\[Function Evaluations\]"/>
<Object cn="Separator=	"/>
<Object cn="String=\[Best Value\]"/>
<Object cn="Separator=	"/>
<Object cn="String=\[Best Parameters\]"/>
</Header>
<Body>
<Object cn="CN=Root,Vector=TaskList[Parameter Estimation],Problem=Parameter Estimation,Reference=Function Evaluations"/>
<Object cn="Separator=	"/>
<Object cn="CN=Root,Vector=TaskList[Parameter Estimation],Problem=Parameter Estimation,Reference=Best Value"/>
<Object cn="Separator=	"/>
<Object cn="CN=Root,Vector=TaskList[Parameter Estimation],Problem=Parameter Estimation,Reference=Best Parameters"/>
</Body>
<Footer>
<Object cn="String=
"/>
<Object cn="CN=Root,Vector=TaskList[Parameter Estimation],Object=Result"/>
</Footer>
</Report>
<Report key="Report_4" name="Metabolic Control Analysis" taskType="metabolicControlAnalysis" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Header>
<Object cn="CN=Root,Vector=TaskList[Metabolic Control Analysis],Object=Description"/>
</Header>
<Footer>
<Object cn="String=
"/>
<Object cn="CN=Root,Vector=TaskList[Metabolic Control Analysis],Object=Result"/>
</Footer>
</Report>
<Report key="Report_3" name="Lyapunov Exponents" taskType="lyapunovExponents" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Header>
<Object cn="CN=Root,Vector=TaskList[Lyapunov Exponents],Object=Description"/>
</Header>
<Footer>
<Object cn="String=
"/>
<Object cn="CN=Root,Vector=TaskList[Lyapunov Exponents],Object=Result"/>
</Footer>
</Report>
<Report key="Report_2" name="Time Scale Separation Analysis" taskType="timeScaleSeparationAnalysis" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Header>
<Object cn="CN=Root,Vector=TaskList[Time Scale Separation Analysis],Object=Description"/>
</Header>
<Footer>
<Object cn="String=
"/>
<Object cn="CN=Root,Vector=TaskList[Time Scale Separation Analysis],Object=Result"/>
</Footer>
</Report>
<Report key="Report_1" name="Sensitivities" taskType="sensitivities" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Header>
<Object cn="CN=Root,Vector=TaskList[Sensitivities],Object=Description"/>
</Header>
<Footer>
<Object cn="String=
"/>
<Object cn="CN=Root,Vector=TaskList[Sensitivities],Object=Result"/>
</Footer>
</Report>
<Report key="Report_0" name="Linear Noise Approximation" taskType="linearNoiseApproximation" separator="	" precision="6">
<Comment>
Automatically generated report.
</Comment>
<Header>
<Object cn="CN=Root,Vector=TaskList[Linear Noise Approximation],Object=Description"/>
</Header>
<Footer>
<Object cn="String=
"/>
<Object cn="CN=Root,Vector=TaskList[Linear Noise Approximation],Object=Result"/>
</Footer>
</Report>
</ListOfReports>
<ListOfPlots>
<PlotSpecification name="Progress of Fit" type="Plot2D" active="1">
<Parameter name="log X" type="bool" value="0"/>
<Parameter name="log Y" type="bool" value="1"/>
<ListOfPlotItems>
<PlotItem name="sum of squares" type="Curve2D">
<Parameter name="Color" type="string" value="auto"/>
<Parameter name="Line subtype" type="unsignedInteger" value="0"/>
<Parameter name="Line type" type="unsignedInteger" value="0"/>
<Parameter name="Line width" type="unsignedFloat" value="1"/>
<Parameter name="Recording Activity" type="string" value="during"/>
<Parameter name="Symbol subtype" type="unsignedInteger" value="0"/>
<ListOfChannels>
<ChannelSpec cn="CN=Root,Vector=TaskList[Parameter Estimation],Problem=Parameter Estimation,Reference=Function Evaluations"/>
<ChannelSpec cn="CN=Root,Vector=TaskList[Parameter Estimation],Problem=Parameter Estimation,Reference=Best Value"/>
</ListOfChannels>
</PlotItem>
</ListOfPlotItems>
</PlotSpecification>
</ListOfPlots>
<GUI>
</GUI>
<SBMLReference file="TryS_104.xml">
<SBMLMap SBMLid="A" COPASIkey="Metabolite_0"/>
<SBMLMap SBMLid="B" COPASIkey="Metabolite_2"/>
<SBMLMap SBMLid="C" COPASIkey="Metabolite_1"/>
<SBMLMap SBMLid="Cell" COPASIkey="Compartment_0"/>
<SBMLMap SBMLid="E" COPASIkey="Metabolite_3"/>
<SBMLMap SBMLid="EA" COPASIkey="Metabolite_5"/>
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<SBMLMap SBMLid="EABC" COPASIkey="Metabolite_26"/>
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