Geneid baseMean log2FoldChange lfcSE stat pvalue padj Length Product Manually_assigned_category KO Class_from_Pwy_association Class_from_KO_Brite Subclass_from_KO_Brite COG COG_category LFTS_00959 491.999251990747 4.7837514867402 0.174907432457904 27.3501898662398 1.07429557401125e-164 2.67069879699198e-161 447 tRNA 2-thiouridine synthesizing protein D NA K07235 Folding, sorting and degradation Folding, sorting and degradation 04122 Sulfur relay system COG1553 P LFTS_00921 759.617776242733 -4.5527888592743 0.200465920547439 -22.7110366033358 3.48524027968605e-114 4.33215366764976e-111 1443 Outer membrane protein TolC NA K15725 NA Signal transduction 02020 Two-component system COG1538 M LFTS_00427 649.478000850295 4.23082031623869 0.189130114482997 22.3698924298967 7.73229623751629e-111 6.40749614882183e-108 1734 dissimilatory adenylylsulfate reductase alpha subunit precursor NA K00394 Energy metabolism Energy metabolism 00920 Sulfur metabolism NA LFTS_00960 218.750421060272 4.60497840986889 0.218787537387433 21.0477180960921 2.39957677875343e-98 1.49133696799526e-95 327 Sulfur relay (sulfurtransferase) complex TusBCD TusD component%2C DsrE family NA K06039 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG1553 P LFTS_02336 2435.27271366882 -2.59716427415177 0.131838592162596 -19.6995753030243 2.17436260786922e-86 1.08109308863258e-83 828 flagellin Motility K02406 Cell motility; Environmental adaptation; Signal transduction; Infectious diseases; Immune system Signal transduction 02020 Two-component system COG1344 N LFTS_01396 5051.43123361374 -3.59816837919915 0.190627263688588 -18.8754132518903 1.81697084943719e-79 7.52831588616811e-77 1383 cytochrome c oxidase cbb3-type subunit 1 Cytochrome cbb3 oxidase K00404 Energy metabolism; Signal transduction Energy metabolism 00190 Oxidative phosphorylation COG3278 C LFTS_00919 993.338851348639 -3.35246276454037 0.178259682682836 -18.8066236519963 6.66498457802371e-79 2.36702166585242e-76 3183 Cu(I)/Ag(I) efflux system membrane protein CusA/SilA Copper/silver resistance K07787 Signal transduction Signal transduction 02020 Two-component system COG3696 P LFTS_00956 200.63660973393 3.89294412052327 0.215798333565394 18.0397320785778 9.50033875074283e-73 2.95223026679334e-70 411 Peroxiredoxin family protein Oxidative stress response K07092 NA Folding, sorting and degradation 04122 Sulfur relay system COG2044 R LFTS_00917 453.642930318274 -3.36033718101686 0.200862733213261 -16.7295203408843 7.98789771862693e-63 2.20643485872295e-60 390 hypothetical protein NA K03546 NA Membrane transport 02010 ABC transporters COG0419 L LFTS_00958 183.639401313004 3.87981886406105 0.233186237457009 16.6382840873118 3.6801340560863e-62 9.14881326343055e-60 387 Sulfur relay (sulfurtransferase) complex TusC component%2C DsrF/TusC family NA K06039 NA Folding, sorting and degradation 04122 Sulfur relay system COG1553 P LFTS_00220 368.993797238116 -3.3565931328476 0.211932985841213 -15.8379929368922 1.70166034808801e-56 3.84575238667891e-54 1182 flagellar biosynthesis protein FlhF Motility K02404 NA Signal transduction 02020 Two-component system COG1419 N LFTS_00428 178.623068654873 3.97033142876654 0.260536410977861 15.2390654874874 1.94634274591478e-52 4.03217338862011e-50 345 adenylylsulfate reductase subunit B NA K00395 Energy metabolism Energy metabolism 00920 Sulfur metabolism NA LFTS_00221 248.607626533693 -3.62459742365615 0.242707558886562 -14.9340112861925 1.97988918511933e-50 3.78615731862051e-48 879 flagellar biosynthesis protein FlhG Motility K04562 NA Signal transduction 02020 Two-component system COG0455 DN LFTS_02037 662.624540796067 -2.5637380499104 0.175164631848842 -14.6361626936354 1.6512848098521e-48 2.93221002663737e-46 3267 heavy metal efflux pump%2C CzcA family Cadmium/cobalt/zinc resistance K07239 NA Metabolism of cofactors and vitamins 00780 Biotin metabolism COG3696 P LFTS_00206 332.975358455187 -2.91670752129926 0.200395776539739 -14.5547354922466 5.44963154056068e-48 9.03185600655591e-46 1389 type III secretion system ATPase%2C FliI/YscN Motility K02412 Cell motility Cell motility 02040 Flagellar assembly COG1157 NU LFTS_02335 839.175990444441 -2.39591397940004 0.165989807501499 -14.4341030058632 3.15726473019817e-47 4.90560007454541e-45 1494 flagellar hook-associated protein 2 Motility K02407 Cell motility Cell motility 02040 Flagellar assembly COG1345 N LFTS_02039 276.806211135614 -3.13104648068536 0.217331528620252 -14.4067752183178 4.69107622373074e-47 6.86000911305565e-45 1236 outer membrane protein%2C cobalt-zinc-cadmium efflux system Cadmium/cobalt/zinc resistance K15725 NA Membrane transport 03070 Bacterial secretion system COG1538 M LFTS_00212 312.42927592871 -3.29855323629669 0.230736056722436 -14.2957857699054 2.32467002547504e-46 3.21062760185053e-44 507 flagellar FliL protein Motility K02415 NA Cell motility 02040 Flagellar assembly COG1580 N LFTS_02331 535.348624984069 -2.6766388301445 0.188059608020042 -14.2329278377483 5.7234423829535e-46 7.48867250738021e-44 2343 Glycosyltransferase involved in cell wall bisynthesis Lipopolysaccharide synthesis K00598 NA Membrane transport 03070 Bacterial secretion system COG0500 QR LFTS_00957 129.670750974848 3.6188459185321 0.254819461399129 14.2016072817289 8.95350326671812e-46 1.11292045605306e-43 255 recombinase NA K04085 Folding, sorting and degradation Folding, sorting and degradation 04122 Sulfur relay system COG0425 O LFTS_00918 374.980701410879 -3.02675217473196 0.216320937643966 -13.9919519936326 1.74554331968576e-44 2.06639080606609e-42 399 Cu and Ag efflux protein CusF Copper/silver resistance K07810 Signal transduction Signal transduction 02020 Two-component system COG5569 P LFTS_02330 290.77749434726 -2.9380744563248 0.210477446732287 -13.9590939644086 2.76931955033686e-44 3.12933109188065e-42 1560 ADP-heptose:LPS heptosyltransferase Lipopolysaccharide synthesis K02843 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG0859 M LFTS_00211 532.242086555904 -2.39964637535378 0.17226889052602 -13.9296559467383 4.18365942823018e-44 4.5219901472088e-42 1374 flagellar hook protein FlgE Motility K02390 Cell motility Cell motility 02040 Flagellar assembly COG1749 N LFTS_00198 273.264326786077 -2.90292895307985 0.210204453101729 -13.8100259544691 2.217516796806e-43 2.29697781535822e-41 1221 two-component system%2C sensor histidine kinase FlrB Motility K10942 Cellular community - prokaryotes; Signal transduction Signal transduction 02020 Two-component system COG0642 T LFTS_01477 244.484236098022 2.93382031299934 0.216565201234549 13.5470532489746 8.24750741741089e-42 8.20132137587339e-40 1644 sulfite reductase (ferredoxin) NA K00366 Energy metabolism Energy metabolism 00910 Nitrogen metabolism COG0155 P LFTS_00219 259.081509238372 -3.19342683365303 0.236640248183907 -13.4948592141909 1.67675152779167e-41 1.60323242234234e-39 2109 flagellar biosynthesis protein FlhA Motility K02400 Cell motility Cell motility 02040 Flagellar assembly COG1298 N LFTS_00916 231.483477936787 -3.10890652983269 0.23216168126035 -13.3911268774209 6.81390077698163e-41 6.27383604873197e-39 372 hypothetical protein NA NA NA NA NA NA NA LFTS_02038 246.470375547814 -3.11638810835719 0.233607098873525 -13.3402971201847 1.34920715818172e-40 1.19790321258562e-38 984 RND family efflux transporter%2C MFP subunit Cadmium/cobalt/zinc resistance K15727 NA Membrane transport 03070 Bacterial secretion system COG0845 MV LFTS_00732 207.994552289815 -3.07924920173782 0.239403382328292 -12.8621791880754 7.34756065680906e-38 6.29863303200942e-36 678 Cytochrome c553 Cytochrome c K00406 Energy metabolism; Signal transduction Energy metabolism 00190 Oxidative phosphorylation COG2010 C LFTS_02340 843.631993706904 -2.13550137284028 0.166350752915962 -12.8373411926732 1.01293877738719e-37 8.3938860019485e-36 1686 flagellar hook-associated protein 1 FlgK Motility K02396 Cell motility Cell motility 02040 Flagellar assembly COG1256 N LFTS_00199 350.336217375217 -2.50680583093345 0.196534628628025 -12.755033799555 2.92247995253418e-37 2.3436403748387e-35 1470 two-component system%2C response regulator FlrC Motility K10943 Cellular community - prokaryotes; Signal transduction Signal transduction 02020 Two-component system COG2204 T LFTS_00203 489.963521549331 -2.4578621900458 0.194999878030807 -12.6044293712712 1.99612047027267e-36 1.55073609034308e-34 1596 flagellar M-ring protein FliF Motility K02409 Cell motility Cell motility 02040 Flagellar assembly COG1766 NU LFTS_02329 281.542966071212 -2.53089724156787 0.202640332544161 -12.4896026856664 8.50774420770122e-36 6.40916730313492e-34 1800 spore maturation protein CgeB Lipopolysaccharide synthesis K06320 NA Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis NA LFTS_02343 437.468726542612 -2.35700211030947 0.189188495687084 -12.4584853944181 1.25735924647429e-35 9.19351496098556e-34 861 flagellin Motility K02406 Cell motility; Environmental adaptation; Signal transduction; Infectious diseases; Immune system Signal transduction 02020 Two-component system COG1344 N LFTS_00197 519.664735252672 -2.86306846198095 0.23726737481379 -12.0668442689515 1.58080821657376e-33 1.12282549325782e-31 2160 Tetratricopeptide repeat-containing protein Motility K05807 NA Overview 01200 Carbon metabolism COG4105 M LFTS_02334 235.6871846175 -2.57253135946049 0.214946969745476 -11.9682141251244 5.21387947949656e-33 3.60047344056346e-31 459 flagellar protein FliS Motility K02422 Cell motility Cell motility 02040 Flagellar assembly COG1516 NU LFTS_00209 287.919448921376 -2.45794918635333 0.207615764937968 -11.838933267364 2.45556271756583e-32 1.6498726799645e-30 1485 hook-length control protein FliK Motility K02414 Cell motility Cell motility 02040 Flagellar assembly COG3144 N LFTS_00429 587.278304655494 2.00243852398033 0.17247323523836 11.6101406761051 3.66012943433438e-31 2.39449520361981e-29 1182 sulfate adenylyltransferase NA K00958 Energy metabolism; Nucleotide metabolism; Biosynthesis of other secondary metabolites; Metabolism of other amino acids Energy metabolism 00920 Sulfur metabolism COG2046 P LFTS_02332 170.061301232086 -2.8660154761529 0.248131830631403 -11.5503741251574 7.34997850209256e-31 4.57827530640774e-29 981 Glycosyl transferases group 1 Lipopolysaccharide synthesis K06320 NA Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis NA LFTS_02328 271.912890004606 -2.29853813649306 0.199004508132682 -11.5501812399172 7.36649285021358e-31 4.57827530640774e-29 1788 ADP-heptose:LPS heptosyltransferase Lipopolysaccharide synthesis K02843 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG0859 M LFTS_00214 149.054320366582 -3.13563450340023 0.272180074463395 -11.5204410520577 1.04076890271196e-30 6.31061339546814e-29 522 flagellar protein FliO/FliZ Motility K02418 Cell motility Cell motility 02040 Flagellar assembly COG3190 N LFTS_00222 195.477026630531 -3.11878196052237 0.27280361173107 -11.4323338343367 2.88255555161968e-30 1.7061983574587e-28 756 RNA polymerase sigma factor for flagellar operon FliA Motility K02405 Cell motility; Cellular community - prokaryotes; Signal transduction Signal transduction 02020 Two-component system COG1191 K LFTS_00210 181.035436204853 -2.65130798146573 0.23325918692676 -11.3663603839029 6.14988367638567e-30 3.5554908882546e-28 831 flagellar basal-body rod modification protein FlgD Motility K02389 Cell motility Cell motility 02040 Flagellar assembly COG1843 N LFTS_00205 182.673876864039 -2.59344993606695 0.237461465050894 -10.9215612542065 9.09193224704135e-28 5.13694171957836e-26 660 putative flagellar assembly protein Motility K02411 Cell motility Cell motility 02040 Flagellar assembly COG1317 NU LFTS_00201 192.033530912713 -2.37140692498717 0.221652741947392 -10.6987484303263 1.03162161362211e-26 5.6991362921435e-25 438 flagellar basal-body rod protein FlgC Motility K02388 Cell motility Cell motility 02040 Flagellar assembly COG1558 N LFTS_00208 345.743925081297 -2.61829037106939 0.24862081525688 -10.5312596950666 6.19991727404152e-26 3.35065094418853e-24 510 hypothetical protein NA K06213 NA Cell motility 02040 Flagellar assembly COG2239 P LFTS_02342 478.070365161751 -1.83290237322776 0.18107258898691 -10.122472890473 4.39176891125023e-24 2.32296542837619e-22 360 anti-sigma-28 factor%2C FlgM family Motility K02398 Cell motility; Cellular community - prokaryotes; Signal transduction Signal transduction 02020 Two-component system COG2747 KN LFTS_00200 237.400752883306 -2.11646025382061 0.209778440145559 -10.0890265575054 6.17791071254747e-24 3.19964292320688e-22 375 flagellar basal-body rod protein FlgB Motility K02387 Cell motility Cell motility 02040 Flagellar assembly COG1815 N LFTS_02345 295.197195558944 -2.03407092580329 0.201772315554375 -10.0810208784819 6.7026068297877e-24 3.40054705690862e-22 1065 flagellar P-ring protein precursor FlgI Motility K02394 Cell motility Cell motility 02040 Flagellar assembly COG1706 N LFTS_00218 107.827417425839 -3.07387693245911 0.306211589432001 -10.0384082070862 1.03328068100595e-23 5.13747154596157e-22 1089 flagellar biosynthetic protein FlhB Motility K02401 Cell motility Cell motility 02040 Flagellar assembly COG1377 N LFTS_02347 126.550312480806 -2.68752210553657 0.270102788720174 -9.94999762227869 2.52189238811671e-23 1.22929891703101e-21 639 flagella basal body P-ring formation protein FlgA Motility K02386 Cell motility Cell motility 02040 Flagellar assembly COG1261 N LFTS_02344 171.427454633236 -2.59252978951708 0.260849610947154 -9.93879109155472 2.82231347596937e-23 1.34928294254997e-21 366 flagellar protein FlgJ Motility K02395 NA Cell motility 02040 Flagellar assembly COG1705 MN LFTS_00213 135.888192557357 -2.64995458526082 0.271980132771675 -9.74319174807313 1.97259336536856e-22 9.25257944586084e-21 378 flagellar motor switch protein FliN/FliY Motility K02417 Cell motility Cell motility 02030 Bacterial chemotaxis COG1886 NU LFTS_01055 1438.78990402782 -1.20603537382132 0.126083803743012 -9.56534731676958 1.11825368953955e-21 5.14810865221355e-20 1287 serine/threonine-protein kinase HipA NA K07154 NA Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG3550 T LFTS_02341 339.850068301716 -1.80212923389652 0.189054042579157 -9.53234963564432 1.53762934844523e-21 6.95008465497243e-20 495 FlgN protein Motility K02399 Cell motility Cell motility 02040 Flagellar assembly COG3418 NU LFTS_00182 94.985712151071 -2.75516384644831 0.290504940713875 -9.48405159539761 2.44597131909146e-21 1.08583655343953e-19 555 hypothetical protein NA NA NA NA NA NA NA LFTS_00223 132.219736507964 -2.43389772271214 0.25942399903416 -9.381929704937 6.4776163115166e-21 2.82514985095268e-19 795 chemotaxis protein methyltransferase CheR Chemotaxis K00575 Signal transduction; Cell motility Signal transduction 02020 Two-component system COG1352 NT LFTS_02337 276.840416765173 -1.87200573079873 0.199762093913079 -9.37117595299777 7.17288447411412e-21 3.07444669011167e-19 432 flagellar assembly factor FliW Motility K13626 NA Cell motility 02040 Flagellar assembly COG1699 N LFTS_00064 1683.53124836037 1.34982933960477 0.144214633039896 9.359863913611 7.98394579900946e-21 3.36408292480297e-19 528 ATP synthase F0 subcomplex B subunit ATP synthase K02109 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG0711 C LFTS_00202 173.83807800559 -2.22190747829339 0.238850186162202 -9.30251516230556 1.37161925176998e-20 5.68307576650029e-19 330 flagellar hook-basal body complex protein FliE Motility K02408 Cell motility Cell motility 02040 Flagellar assembly COG1677 N LFTS_02327 205.615989083396 -2.60343374545517 0.280736955620647 -9.27356977174435 1.8001788563832e-20 7.33646661798138e-19 654 hypothetical protein NA K11938 NA Overview 01200 Carbon metabolism COG0561 HR LFTS_00204 299.429917188407 -2.25005083822586 0.244206175215183 -9.21373440390369 3.14971872918511e-20 1.26293560657326e-18 1005 flagellar motor switch protein FliG Motility K02410 Cell motility Cell motility 02030 Bacterial chemotaxis COG1536 N LFTS_02346 141.708505825128 -2.19219509681876 0.239432684932385 -9.15578880735447 5.39621155529421e-20 2.12936221054943e-18 627 flagellar L-ring protein precursor FlgH Motility K02393 Cell motility Cell motility 02040 Flagellar assembly COG2063 N LFTS_00207 263.994740061023 -2.25380693451639 0.247560995920221 -9.1040469688638 8.70271202679097e-20 3.38045970290662e-18 444 flagellar export protein FliJ Motility K02413 Cell motility Cell motility 02040 Flagellar assembly COG2882 N LFTS_00586 1494.51374543608 1.18057173794304 0.13078339953539 9.02692346381151 1.76565825715922e-19 6.75296373430434e-18 1191 succinyl-CoA synthetase beta subunit Reductive TCA cycle carbon dioxide fixation K01903 Carbohydrate metabolism; Overview; Energy metabolism Overview 01200 Carbon metabolism COG0045 C LFTS_02333 114.648611976239 -2.42447362825079 0.268891982505098 -9.01653372355506 1.94134672651041e-19 7.31240600318922e-18 345 hypothetical protein NA NA NA NA NA NA NA LFTS_00731 298.803912510823 -1.97866046261914 0.222964016721987 -8.87434883758091 7.03437566728321e-19 2.61006834460688e-17 810 Cytochrome c Cytochrome c K03889 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG2010 C LFTS_00513 601.760386780409 -1.35591763323161 0.155261840913826 -8.73310290056513 2.47779477944852e-18 9.05852620839563e-17 471 hypothetical protein NA NA NA NA NA NA NA LFTS_02310 255.45404421815 -1.90992969593802 0.221288049404629 -8.63096629518244 6.08358105466754e-18 2.19185253650775e-16 1272 Glycosyltransferase%2C catalytic subunit of cellulose synthase and poly-beta-1%2C6-N-acetylglucosamine synthase Cellulose production K00694 Carbohydrate metabolism; Cellular community - prokaryotes Carbohydrate metabolism 00500 Starch and sucrose metabolism COG1215 N LFTS_00662 659.022091960335 -1.85100905692093 0.214845489440672 -8.61553603820049 6.96151201759876e-18 2.47233126796436e-16 681 hypothetical protein NA NA NA NA NA NA NA LFTS_00563 452.821870670106 1.80034290762305 0.209266455276487 8.60311274085665 7.75826986268967e-18 2.71648716600655e-16 324 hypothetical protein NA NA NA NA NA NA NA LFTS_02349 150.917953468773 -2.58110981880141 0.301603016518866 -8.55797083395536 1.14871414280784e-17 3.96625466530597e-16 804 flagellar basal-body rod protein FlgG Motility K02392 Cell motility Cell motility 02040 Flagellar assembly COG1749 N LFTS_00479 175.800634823285 -1.80572837328737 0.215992325741794 -8.36015060760082 6.26382400508223e-17 2.13313239405951e-15 2109 diguanylate cyclase (GGDEF) domain-containing protein Genes encoding proteins with EAL and GGDEF domains K14051 Cellular community - prokaryotes Cellular community - prokaryotes 02024 Quorum sensing COG2199;COG2200;COG2202 T LFTS_01887 833.501516623115 -1.39805446719707 0.167866391747501 -8.32837623209283 8.1958693775768e-17 2.75336909089945e-15 210 hypothetical protein NA NA NA NA NA NA NA LFTS_00215 94.3495498297064 -2.52177665587604 0.305614160136868 -8.25150462513477 1.56412582067364e-16 5.18455572025955e-15 798 flagellar biosynthetic protein FliP Motility K02419 Cell motility Cell motility 02040 Flagellar assembly COG1338 N LFTS_02348 178.023559816059 -2.07855527801109 0.252016323183254 -8.24770098919216 1.61470776877569e-16 5.28179409628469e-15 786 flagellar basal-body rod protein FlgG Motility K02392 Cell motility Cell motility 02040 Flagellar assembly COG1749 N LFTS_00772 585.875654468223 -1.6539057306725 0.201738321059049 -8.19827250464923 2.43866042419212e-16 7.87338936953455e-15 687 hypothetical protein NA NA NA NA NA NA NA LFTS_02338 156.013184952523 -2.03160030919884 0.248581129028108 -8.17278575063967 3.01348859586077e-16 9.60452903757675e-15 243 carbon storage regulator%2C CsrA Motility K03563 Cellular community - prokaryotes; Signal transduction Signal transduction 02020 Two-component system COG1551 T LFTS_00065 1431.51952558089 1.16190301538429 0.142510851482536 8.15308450757994 3.54757525916219e-16 1.11636355623762e-14 570 F-type H+-transporting ATPase subunit delta ATP synthase K02113 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG0712 C LFTS_00099 1057.67046016845 1.26544581846897 0.157587780734302 8.03010114472363 9.73923397279304e-16 3.02646695704544e-14 948 lipoprotein NA NA NA NA NA NA NA LFTS_00226 211.057313611765 -1.62323335902243 0.204773058010607 -7.92698695225005 2.2452686903283e-15 6.89103452364957e-14 1035 two-component system%2C chemotaxis family%2C response regulator CheB Chemotaxis K03412 Signal transduction; Cell motility Signal transduction 02020 Two-component system COG2201 NT LFTS_00771 382.400055467114 -2.23726858534992 0.28467611338193 -7.85899652335187 3.87222982915027e-15 1.17394675064239e-13 273 hypothetical protein NA K11261 Energy metabolism; Overview Overview 01200 Carbon metabolism COG2191 C LFTS_02251 3602.93470501743 1.12800062326633 0.144743118234281 7.79312092365286 6.53740018962338e-15 1.95806950257876e-13 618 Transglycosylase SLT domain-containing protein NA K08309 NA Replication and repair 03030 DNA replication COG0741 M LFTS_02494 3322.12459336525 0.938480740504829 0.120855542828567 7.76530987772784 8.1445851057072e-15 2.41040935390335e-13 1131 ribonuclease-3 NA K03685 Translation; Cancers Translation 03008 Ribosome biogenesis in eukaryotes COG0571 K LFTS_02472 686.600709305094 -1.15293140093969 0.148956270440541 -7.74006624581744 9.93650277144914e-15 2.90613481056736e-13 1032 hypothetical protein NA K05142 Signaling molecules and interaction Signaling molecules and interaction 04060 Cytokine-cytokine receptor interaction NA LFTS_01548 213.371563911531 -1.55961666309007 0.202184115389678 -7.7138436918457 1.22083981468241e-14 3.52907881314008e-13 1119 methyl-accepting chemotaxis protein Chemotaxis K03406 Signal transduction; Cell motility Signal transduction 02020 Two-component system COG0840 NT LFTS_01663 2458.00013288416 0.951986546805868 0.125207831142182 7.60325083600259 2.88782974720833e-14 8.25189051903437e-13 375 small subunit ribosomal protein S12 NA K02950 Translation Translation 03010 Ribosome COG0048 J LFTS_00225 722.259286660444 -1.32719506729956 0.175772730890129 -7.55063120757429 4.33153774542823e-14 1.22365941308348e-12 1941 two-component system%2C chemotaxis family%2C sensor kinase CheA Chemotaxis K03407 Signal transduction; Cell motility Signal transduction 02020 Two-component system COG0643 NT LFTS_00217 73.106954336866 -2.36858156609259 0.317101291332467 -7.46947940873956 8.05127060175855e-14 2.2489279456148e-12 789 flagellar biosynthetic protein FliR Motility K02421 Cell motility Cell motility 02040 Flagellar assembly COG1684 N LFTS_00920 439.974550328707 -2.96364448591165 0.398903449655512 -7.42947820699725 1.09026907978237e-13 3.01156548037663e-12 1260 membrane fusion protein%2C Cu(I)/Ag(I) efflux system Copper/silver resistance K07798 Signal transduction Signal transduction 02020 Two-component system COG0845 MV LFTS_01784 865.558067129531 1.79867765386458 0.242595351014795 7.41431213063468 1.22257678312923e-13 3.33991855259261e-12 1083 hypothetical protein NA NA NA NA NA NA NA LFTS_00062 1673.41957942539 0.975789424890175 0.132011316556831 7.39171042559896 1.44951938809311e-13 3.89349937198312e-12 735 F-type H+-transporting ATPase subunit a ATP synthase K02108 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG0356 C LFTS_01994 5767.07004387642 -1.22985962589969 0.166398088337392 -7.3910682399548 1.45653838131307e-13 3.89349937198312e-12 981 porphobilinogen synthase NA K01698 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0113 H LFTS_02276 40716.2706047874 1.12104299381188 0.15175074770376 7.38739683840192 1.49731217994316e-13 3.95991285036033e-12 555 Cytochrome C oxidase%2C cbb3-type%2C subunit III Cytochrome cbb3 oxidase K00406 Energy metabolism; Signal transduction Energy metabolism 00190 Oxidative phosphorylation COG2010 C LFTS_02213 214.10774526947 1.3548224910756 0.184543757612022 7.34147016732983 2.11260247922746e-13 5.52834711932575e-12 357 hypothetical protein NA K09132 NA Amino acid metabolism 00270 Cysteine and methionine metabolism COG1895 S LFTS_00299 4548.64175731722 0.97075957207977 0.13288899624724 7.30504104548786 2.77182116120808e-13 7.1778618820451e-12 1059 hypothetical protein NA K07586 NA Translation 00970 Aminoacyl-tRNA biosynthesis COG3557 S LFTS_00521 237.326829974904 -1.6723169368329 0.229278914806694 -7.2938104153312 3.01309353539613e-13 7.7222170402008e-12 3237 Tfp pilus assembly protein PilF NA K02656 NA Overview 01200 Carbon metabolism COG3063 NW LFTS_01001 559.971228178528 1.07336275188826 0.14824147428399 7.24063732550306 4.46581144502516e-13 1.13285788289108e-11 1095 Streptogramin lyase NA K00504 NA Energy metabolism 00190 Oxidative phosphorylation NA LFTS_02311 588.157967027381 -1.088322019446 0.152725103250369 -7.12601920891723 1.03313305564862e-12 2.59431189529543e-11 2895 Tetratricopeptide repeat-containing protein Cellulose production K02656 NA Signal transduction 02020 Two-component system COG3063 NW LFTS_01856 1076.22070209886 -1.11222432814216 0.156318171484733 -7.1151313860576 1.1180627646251e-12 2.77700862617836e-11 222 sec-independent protein translocase protein TatA NA K03116 Folding, sorting and degradation; Membrane transport Folding, sorting and degradation 03060 Protein export COG1826 U LFTS_02541 11156.9387220509 -0.908205322211017 0.12766661273303 -7.11388281374876 1.12822957057125e-12 2.77700862617836e-11 2316 acetolactate synthase%2C large subunit NA K01652 Metabolism of cofactors and vitamins; Amino acid metabolism; Overview; Carbohydrate metabolism Overview 01210 2-Oxocarboxylic acid metabolism COG0028 EH LFTS_00578 3147.95666431712 1.07544078823927 0.15207999503188 7.07154670812445 1.53216213150406e-12 3.73426966560694e-11 1251 citryl-CoA synthetase large subunit Reductive TCA cycle carbon dioxide fixation K15232 Overview; Energy metabolism Overview 01200 Carbon metabolism NA LFTS_00370 371.555855898584 -1.15712247202527 0.165130520077946 -7.00732046068209 2.42925437837049e-12 5.86322949963985e-11 204 sulfur carrier protein NA K03154 Folding, sorting and degradation Folding, sorting and degradation 04122 Sulfur relay system COG2104 H LFTS_00740 649.130388186598 -1.18059751163654 0.168678269376925 -6.99910851585981 2.57596292656414e-12 6.15754214946005e-11 672 Cytochrome c553 Cytochrome c K00406 Energy metabolism; Signal transduction Energy metabolism 00190 Oxidative phosphorylation COG2010 C LFTS_02339 719.811815750137 -1.16483427899934 0.167850335016628 -6.93971971449413 3.92878642328032e-12 9.3018695697856e-11 939 flagellar hook-associated protein 3 FlgL Motility K02397 Cell motility Cell motility 02040 Flagellar assembly COG1344 N LFTS_00229 255.214851143399 -1.4129855915976 0.203832007264598 -6.93210850719523 4.14613730079222e-12 9.72386540544289e-11 783 chemotaxis protein MotA Chemotaxis K02556 Cell motility; Signal transduction Signal transduction 02020 Two-component system COG1291 N LFTS_00463 1231.2892559806 -1.05592672912186 0.158614406075817 -6.65719309642741 2.7910640059372e-11 6.48465898949521e-10 576 peroxiredoxin Q/BCP Oxidative stress response K03564 NA Metabolism of cofactors and vitamins 00730 Thiamine metabolism COG1225 O LFTS_00275 716.01501060224 1.35439832296538 0.204272181912669 6.63036107160404 3.34866718709439e-11 7.70813576584875e-10 768 hypothetical protein NA NA NA NA NA NA NA LFTS_00133 222.862384522563 -1.37181838241196 0.207798919610116 -6.6016627275341 4.06571652107379e-11 9.27281768017379e-10 1077 regulatory protein%2C luxR family Quorum sensing K07684 Signal transduction Signal transduction 02020 Two-component system COG2197 TK LFTS_00762 573.998215757867 -1.0568340150222 0.160488298690062 -6.58511569783151 4.54531302055026e-11 1.02724074264436e-09 630 hypothetical protein NA NA NA NA NA NA NA LFTS_00736 441.004951639465 -1.04937483471675 0.159393500030582 -6.58354847917518 4.59350713808361e-11 1.02878006714197e-09 1056 Cellulose biosynthesis protein BcsQ Cellulose production K03496 NA Energy metabolism 00190 Oxidative phosphorylation COG1192 N LFTS_00830 427.056405218077 -1.12147236100999 0.170907523576102 -6.5618665436377 5.31383650541023e-11 1.17948192432588e-09 1260 tRNA nucleotidyltransferase (CCA-adding enzyme) NA K00974 Translation Translation 03013 RNA transport COG0617 J LFTS_01395 102.706068589867 -1.67001116282924 0.255164179267368 -6.54484954598333 5.95553117808699e-11 1.31021685917914e-09 1089 Transposase (or an inactivated derivative) NA K07493 NA Carbohydrate metabolism 00010 Glycolysis / Gluconeogenesis COG3328 X LFTS_00939 1149.6668791101 -1.33899409402152 0.20666165155722 -6.47916090833518 9.22341012827257e-11 2.01135066481453e-09 696 transcriptional regulator%2C TetR family NA K09017 NA Folding, sorting and degradation 04122 Sulfur relay system COG1309 K LFTS_02175 650.848757232411 -0.987107079964716 0.153608322505296 -6.42613019832102 1.30893303443681e-10 2.8295717596608e-09 759 sec-independent protein translocase protein TatC NA K03118 Folding, sorting and degradation; Membrane transport Folding, sorting and degradation 03060 Protein export COG0805 U LFTS_01974 10969.275694033 0.758731121336753 0.118275682805739 6.41493757075089 1.40880581200126e-10 3.01921659365097e-09 234 hypothetical protein NA K03975 NA Energy metabolism 00190 Oxidative phosphorylation COG0586 S LFTS_01770 1160.3384668112 0.901153847746729 0.143507162577441 6.27950432272284 3.39654153087977e-10 7.21692499638214e-09 765 HDIG domain-containing protein NA K07814 NA Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG3437 T LFTS_01733 464.842945017512 -1.53662094083629 0.245103328240568 -6.26927815247006 3.62725676444689e-10 7.64183077662285e-09 135 hypothetical protein NA NA NA NA NA NA NA LFTS_01263 1496.79141591323 -0.961037093574704 0.153897326292757 -6.24466400245665 4.24712092794269e-10 8.87255682929877e-09 1251 IPT/TIG domain-containing protein NA K09103 NA Overview 01200 Carbon metabolism NA LFTS_02540 5129.8178728433 -1.10134844769794 0.177419362198459 -6.20760008406516 5.37998461386533e-10 1.11455347917243e-08 1020 ketol-acid reductoisomerase NA K00053 Metabolism of cofactors and vitamins; Amino acid metabolism; Overview Overview 01210 2-Oxocarboxylic acid metabolism COG0059 EH LFTS_01775 750.108312089225 1.08526265687303 0.175338653754553 6.18952315210669 6.03464894011092e-10 1.23984605496824e-08 264 hypothetical protein NA NA NA NA NA NA NA LFTS_00433 1201.1565423596 -0.807385932595079 0.130754486789693 -6.17482391937869 6.62372488452364e-10 1.349719677289e-08 1521 MFS transporter%2C DHA2 family%2C multidrug resistance protein NA K03446 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0477 GEPR LFTS_00519 551.235295909653 -2.34914669582099 0.382543249653296 -6.14086563532372 8.20729862400748e-10 1.65880848612054e-08 888 PEP-CTERM protein-sorting domain-containing protein NA NA NA NA NA NA NA LFTS_00569 54.528006720434 -2.13292679646933 0.348919994663977 -6.11293943909239 9.7812497864938e-10 1.96098282009868e-08 1848 glucosamine--fructose-6-phosphate aminotransferase (isomerizing) Extracellular polysaccharide production and export K00820 Amino acid metabolism; Carbohydrate metabolism; Endocrine and metabolic diseases Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG0449 M LFTS_01385 230.991224794855 -1.18993753791233 0.195456794865804 -6.08798245530075 1.14342397958689e-09 2.2740416106024e-08 1779 ABC-2 type transport system ATP-binding protein NA K01990 NA Energy metabolism 00920 Sulfur metabolism COG1131;COG1134 VGM LFTS_01673 3077.31692924848 1.07177983333253 0.176220764322305 6.08202919476765 1.18670952689106e-09 2.34139673321523e-08 1200 translation elongation factor 1A (EF-1A/EF-Tu) NA K02358 NA Folding, sorting and degradation 03060 Protein export COG0050 J LFTS_00534 72.2148725740402 -1.97548007448608 0.327183984752092 -6.03782631959478 1.56204056302883e-09 3.05766365329895e-08 1416 two-component system%2C NtrC family%2C response regulator Nitrate/nitrite regulation K02481 NA Cell motility 02040 Flagellar assembly COG2204 T LFTS_01554 1590.68824101923 0.716309992532318 0.11947052758377 5.99570460614277 2.02605017700959e-09 3.93496932816082e-08 300 acylphosphatase NA K01512 Carbohydrate metabolism; Xenobiotics biodegradation and metabolism Carbohydrate metabolism 00620 Pyruvate metabolism COG1254 C LFTS_00555 70.6740905360452 -2.05729433402071 0.344892464159164 -5.96503127151915 2.44587194609188e-09 4.71351756432901e-08 132 hypothetical protein NA NA NA NA NA NA NA LFTS_00068 2611.73634064028 0.779093916224896 0.130826027021685 5.95519052256902 2.59769028216606e-09 4.9675831088191e-08 1392 F-type H+-transporting ATPase subunit beta ATP synthase K02133 Neurodegenerative diseases; Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG0055 C LFTS_01846 9195.55014725664 -1.28194968941047 0.217906260548353 -5.88303285176154 4.02815931938798e-09 7.64427791450269e-08 657 PAS fold-containing protein NA NA NA NA NA NA NA LFTS_00092 643.842303368128 0.858895829988575 0.146970386163132 5.8440060777634 5.09601673878472e-09 9.59749819137788e-08 198 large subunit ribosomal protein L35 NA K02916 Translation Translation 03010 Ribosome COG0291 J LFTS_00180 1496.4358214669 -1.00078241636267 0.172185589266193 -5.81223098069777 6.16457007843132e-09 1.15226475300603e-07 1404 hypothetical protein NA NA NA NA NA NA NA LFTS_00327 614.504003284371 -0.90060328092584 0.155212582278739 -5.80238578408863 6.53779267039127e-09 1.2129069088502e-07 3264 Multidrug efflux pump subunit AcrB NA K03296 NA Signal transduction 02020 Two-component system COG0841 V LFTS_01939 7060.05180612965 0.906359619543448 0.156526883726417 5.79044058097786 7.02020305722016e-09 1.29275739261106e-07 966 cytochrome c class I NA K02305 Energy metabolism Energy metabolism 00910 Nitrogen metabolism NA LFTS_01444 369.088503971182 1.02703038383546 0.17781263001652 5.77591357678048 7.65366534658895e-09 1.3990450037956e-07 867 Cytochrome C biogenesis protein transmembrane region NA K08970 NA Overview 01200 Carbon metabolism COG2215 P LFTS_00030 723.737022290295 -0.820201084031243 0.142896514680324 -5.73982567640736 9.4774057469764e-09 1.71976866328345e-07 582 carbonic anhydrase Proton consuming reactions K01673 Energy metabolism Energy metabolism 00910 Nitrogen metabolism COG0288 P LFTS_02302 461.26176576684 -0.947422202076093 0.165323781148525 -5.7307073156338 1.00012708053786e-08 1.80167820450517e-07 1470 outer membrane protein assembly factor BamB NA K05889 NA Lipid metabolism 00564 Glycerophospholipid metabolism NA LFTS_00940 890.675826539493 -1.26642200536925 0.222310032624933 -5.69664801185952 1.22185819566665e-08 2.18528019742971e-07 603 Cytochrome c554 and c-prime Cytochrome c K04013 NA Folding, sorting and degradation 03018 RNA degradation NA LFTS_01225 955.46659779957 -0.913559627461588 0.1620925906454 -5.63603569925123 1.74009322029153e-08 3.08990838974624e-07 564 Endonuclease%2C Uma2 family (restriction endonuclease fold) NA NA NA NA NA NA NA LFTS_00048 478.448563569894 -1.18465623676349 0.210414463785026 -5.63010838443982 1.80096412831751e-08 3.17531689574279e-07 1107 Chemoreceptor zinc-binding domain-containing protein NA K03406 Signal transduction; Cell motility Signal transduction 02020 Two-component system COG0840 NT LFTS_02252 1489.92094930535 1.07214572513495 0.191042123130947 5.61209071362793 1.99896593116113e-08 3.49959810201872e-07 333 hypothetical protein NA NA NA NA NA NA NA LFTS_01382 102.717592227517 -1.82145913381591 0.326159078110693 -5.58457285434727 2.34275294559228e-08 4.07278589002966e-07 693 biopolymer transport protein ExbB NA K03561 NA Membrane transport 03070 Bacterial secretion system COG0811 U LFTS_01292 1148.71908350534 0.760562516047015 0.137121644535975 5.54662627202865 2.91234322233098e-08 5.02783697966307e-07 1053 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase Lipopolysaccharide synthesis K02536 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG1044 M LFTS_00034 3007.23575277312 -0.716096864836177 0.129625873607773 -5.52433588222496 3.30734221472708e-08 5.67038120400794e-07 1044 EAL domain%2C c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant) c-di-GMP specific phosphodiestereases (EAL domain-containing proteins) K14051 Cellular community - prokaryotes Cellular community - prokaryotes 02024 Quorum sensing COG2199;COG2200;COG2202 T LFTS_00752 485.522713375626 -0.83336297056495 0.151093618295437 -5.5155404971205 3.47709662268536e-08 5.92059055068205e-07 312 Copper chaperone CopZ Copper resistance K08364 NA Energy metabolism 00190 Oxidative phosphorylation COG2608 P LFTS_00066 2257.30667490818 0.750815562474206 0.136914273137487 5.48383704100924 4.16198185794941e-08 7.03856251623281e-07 1524 ATP synthase F1 subcomplex alpha subunit ATP synthase K02111 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG0056 C LFTS_00570 58.2629436452779 -1.9370584955604 0.353982479474734 -5.4721874891513 4.44514181094034e-08 7.46663685270115e-07 1302 UDP-N-acetyl-D-glucosamine dehydrogenase Extracellular polysaccharide production and export K13015 Carbohydrate metabolism Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG0677 M LFTS_00955 275.613216009719 0.986208958152679 0.181423212930856 5.43595795830463 5.45028059157567e-08 9.07109001388895e-07 783 cobalamin-5'-phosphate synthase NA K02233 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0368 H LFTS_01262 3888.84370970035 -0.849236756980442 0.156247380070953 -5.43520637974729 5.47330451360958e-08 9.07109001388895e-07 3411 hypothetical protein NA K06872 NA Overview 01200 Carbon metabolism COG1512 S LFTS_00196 1187.94084089893 0.724196681411151 0.133737676110286 5.41505357707837 6.12703567482289e-08 1.00872918460991e-06 1035 sigma-54 specific transcriptional regulator%2C flagellar regulatory protein A Motility K10941 Cellular community - prokaryotes; Signal transduction Signal transduction 02020 Two-component system COG2204 T LFTS_01640 2615.34928891674 0.969723907580735 0.179307830353495 5.40815147709377 6.36785580120384e-08 1.04147957380215e-06 375 small subunit ribosomal protein S13 NA K02952 Translation Translation 03010 Ribosome COG0099 J LFTS_00755 2024.85112407637 -1.09821716218625 0.203179204085067 -5.40516519459567 6.47486898110958e-08 1.05206041091754e-06 507 Heavy-metal resistance Metal tolerance K11165 NA Energy metabolism 00190 Oxidative phosphorylation NA LFTS_02083 286.94638280247 -0.984740257441185 0.182679210138785 -5.39054365679083 7.0244847593839e-08 1.12787936155602e-06 444 Rrf2 family protein NA K13771 Infectious diseases Infectious diseases 05132 Salmonella infection COG1959 K LFTS_00115 1606.93789829753 -0.699586317837591 0.129785059067939 -5.39034556721491 7.03223254389311e-08 1.12787936155602e-06 705 Modulator of FtsH protease YccA NA K06890 NA Overview 01210 2-Oxocarboxylic acid metabolism COG0670 R LFTS_00183 365.79571630869 -0.996623839890899 0.185030874218959 -5.38625699142258 7.19400815707974e-08 1.14642976144232e-06 1365 methyl-accepting chemotaxis protein Chemotaxis K03406 Signal transduction; Cell motility Signal transduction 02020 Two-component system COG0840 NT LFTS_00644 3745.84928710263 0.798369763483251 0.148452689196759 5.37794072847743 7.53426096740062e-08 1.1930046347107e-06 1158 methionine adenosyltransferase NA K00789 Amino acid metabolism; Overview Overview 01230 Biosynthesis of amino acids COG0192;COG1812 H LFTS_01288 8951.35510883561 -0.735143360647905 0.137517750291279 -5.34580706193041 9.00150540875328e-08 1.41631281304814e-06 1056 Site-specific recombinase XerD NA K04763 NA Amino acid metabolism 00270 Cysteine and methionine metabolism COG0582 LX LFTS_01611 2298.07410377315 -0.680361537585715 0.127918681109237 -5.31870350511756 1.04509281715879e-07 1.62921772560286e-06 1041 hypothetical protein NA K07718 Signal transduction Signal transduction 02020 Two-component system COG2972 T LFTS_00350 310.683158579294 1.40005038683044 0.263261447688788 5.31809879160696 1.04857134391173e-07 1.62921772560286e-06 564 L-2%2C4-diaminobutyric acid acetyltransferase NA K06718 Amino acid metabolism Amino acid metabolism 00260 Glycine, serine and threonine metabolism COG0454 KR LFTS_00266 979.345767355044 1.0917022393613 0.206824757345549 5.27839245829431 1.30322113540442e-07 2.01230294572384e-06 531 Tetratricopeptide repeat-containing protein NA K02656 NA Amino acid metabolism 00250 Alanine, aspartate and glutamate metabolism COG3063 NW LFTS_01495 602.742014027475 -0.896599031982217 0.170433010184492 -5.26071229400724 1.43498417276222e-07 2.1865102994068e-06 1017 N-acetylneuraminic acid mutarotase NA K10450 NA Folding, sorting and degradation 04120 Ubiquitin mediated proteolysis NA LFTS_00227 555.925643471754 -1.10091716492555 0.209287896981259 -5.26030019320292 1.43820408540195e-07 2.1865102994068e-06 1674 methyl-accepting chemotaxis protein Chemotaxis K03406 Signal transduction; Cell motility Signal transduction 02020 Two-component system COG0840 NT LFTS_01847 669.584006481742 1.12522461422436 0.213949066251321 5.25931070389708 1.4459639306071e-07 2.1865102994068e-06 648 hypothetical protein NA K07244 NA Nucleotide metabolism 00230 Purine metabolism COG1824 P LFTS_01897 1209.44278764638 -0.892875654456478 0.169792029239353 -5.25864293192354 1.45122365004876e-07 2.1865102994068e-06 402 hypothetical protein NA NA NA NA NA NA NA LFTS_00348 665.067529661539 1.99627002214699 0.380733836074914 5.24321673830481 1.57800990487789e-07 2.3632124238111e-06 396 L-ectoine synthase NA K06720 Amino acid metabolism Amino acid metabolism 00260 Glycine, serine and threonine metabolism NA LFTS_00580 11493.0679835196 0.786956362531381 0.150473712450952 5.22985942004916 1.69638988228274e-07 2.52528457925443e-06 153 hypothetical protein NA NA NA NA NA NA NA LFTS_00426 2957.95788165748 -1.16812901804319 0.223473154353826 -5.22715590344998 1.72137347965231e-07 2.54722289905693e-06 123 hypothetical protein NA NA NA NA NA NA NA LFTS_01677 2084.42810729588 0.736665118620438 0.14212727446463 5.1831368848473 2.18184784747298e-07 3.20951109397504e-06 762 hypothetical protein NA NA NA NA NA NA NA LFTS_01451 11914.9431057352 0.774764975859481 0.15000610390586 5.1648896657279 2.40580792133332e-07 3.51814028966743e-06 3147 NADH-quinone oxidoreductase subunit F NADH dehydrogenase K05587 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG1894 C LFTS_00359 589.352646335013 0.843788093765427 0.163561494887093 5.15884312715471 2.48480390318827e-07 3.61241082065851e-06 1455 hypothetical protein NA K09859 NA Membrane transport 03070 Bacterial secretion system COG3014 S LFTS_01598 428.167885530757 -1.4123186297392 0.274176117034097 -5.15113659430651 2.58912522216765e-07 3.74218912924929e-06 165 hypothetical protein NA NA NA NA NA NA NA LFTS_02263 427.079864989255 0.841362115361988 0.163671073573589 5.14056697369739 2.73910665638329e-07 3.93608043223633e-06 702 phosphoribosyl-ATP pyrophosphatase /phosphoribosyl-AMP cyclohydrolase NA K11755 Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG0140;COG0139 E LFTS_00063 642.958082786481 0.757693266162869 0.147729758047953 5.12891428358614 2.91417986244889e-07 4.16359260807353e-06 231 F-type H+-transporting ATPase subunit c ATP synthase K02128 Neurodegenerative diseases; Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG0636 C LFTS_02497 577.305483294962 0.814661455038335 0.159106063156169 5.12024142184142 3.05144758454018e-07 4.33479925438108e-06 399 Polymer-forming protein NA NA NA NA NA NA NA LFTS_02277 921.653226231964 -0.69347669848732 0.135673434904315 -5.11136685657291 3.19836200649833e-07 4.51768633417889e-06 1017 Acetoin utilization deacetylase AcuC NA K11407 Cancers; Substance dependence Cancers 05203 Viral carcinogenesis NA LFTS_00657 634.744983438122 0.815924392550742 0.159847071795001 5.10440625147727 3.31834725839373e-07 4.66068434145017e-06 957 Endonuclease IV NA K01151 Replication and repair Replication and repair 03410 Base excision repair COG0648 L LFTS_01029 626.606479322444 -0.949732386797966 0.186322805237086 -5.09724177665466 3.44638047758088e-07 4.79075153049427e-06 240 hypothetical protein NA K08197 NA Signal transduction 02020 Two-component system NA LFTS_01935 968.352390183644 0.787095328170918 0.154421112548775 5.09707069959302 3.44949526934221e-07 4.79075153049427e-06 996 protease-4 NA K04773 NA Energy metabolism 00190 Oxidative phosphorylation COG0616 O LFTS_00550 38.7156771173579 -1.83067543115138 0.360082592856491 -5.08404312640846 3.69483986942683e-07 5.10298439744173e-06 858 polysaccharide export outer membrane protein Extracellular polysaccharide production and export K01991 Cellular community - prokaryotes Cellular community - prokaryotes 02026 Biofilm formation - Escherichia coli COG1596 M LFTS_02218 102.982578581099 -1.25440648668028 0.246829967925077 -5.08206721098406 3.73349251459729e-07 5.12787977419274e-06 942 Integrase core domain-containing protein NA K02315 NA Cell growth and death 04112 Cell cycle - Caulobacter COG1484 L LFTS_02279 936.260684760372 -0.822803599773229 0.162239049699956 -5.0715509077187 3.94586677269604e-07 5.36222802775939e-06 360 hypothetical protein NA NA NA NA NA NA NA LFTS_00943 1443.84458948662 -1.22446222418959 0.241440618870145 -5.07148395294722 3.94725554738523e-07 5.36222802775939e-06 1395 outer membrane protein NA K12340 Drug resistance; Signal transduction; Membrane transport; Infectious diseases; Environmental adaptation Membrane transport 03070 Bacterial secretion system COG1538 M LFTS_00537 64.4647922097893 -1.58268173905144 0.312261467589519 -5.06845033192485 4.0106760580712e-07 5.41877210889403e-06 924 UTP--glucose-1-phosphate uridylyltransferase Extracellular polysaccharide production and export K00973 Biosynthesis of other secondary metabolites; Metabolism of terpenoids and polyketides Metabolism of terpenoids and polyketides 00523 Polyketide sugar unit biosynthesis COG1209 M LFTS_00103 3084.73066144215 0.695539990145165 0.137283854904036 5.06643691373147 4.05330996623712e-07 5.44677220327864e-06 279 large subunit ribosomal protein L27 NA K02899 Translation Translation 03010 Ribosome COG0211 J LFTS_00734 122.419109084713 -1.20753280948554 0.239012157881614 -5.0521815299607 4.367922647146e-07 5.83798693591664e-06 522 PEGA domain-containing protein NA NA NA NA NA NA NA LFTS_00765 973.185254300337 -0.745377047765436 0.147820620896314 -5.04244295042074 4.59625810604911e-07 6.11031959980646e-06 747 Ferredoxin-NADP reductase NA K00523 Carbohydrate metabolism Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG0543 HC LFTS_00340 5025.62179590924 -0.563091204708815 0.111983339592745 -5.02834802709612 4.94723370973643e-07 6.5419271289387e-06 1347 proteasome accessory factor A NA K13571 NA Amino acid metabolism 00260 Glycine, serine and threonine metabolism NA LFTS_02055 1413.5701239422 -0.751777663753485 0.149867096554375 -5.01629564485973 5.26772494572663e-07 6.92886995506688e-06 303 ParE toxin of type II toxin-antitoxin system%2C parDE NA NA NA NA NA NA NA LFTS_00518 61.5710042374113 -1.50424124037049 0.300274729587269 -5.00954989598388 5.4557481171447e-07 7.13841569432722e-06 696 PEP-CTERM protein-sorting domain-containing protein NA NA NA NA NA NA NA LFTS_01941 5415.20948813127 0.809721322801169 0.161987970450058 4.99865095260769 5.77328011792478e-07 7.51433213254503e-06 831 hypothetical protein NA K03888 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG1290;COG2010 C LFTS_02454 2449.39368921326 0.740728740243589 0.148600016594494 4.9847150573672 6.20531922828208e-07 8.03459562578607e-06 285 hypothetical protein NA NA NA NA NA NA NA LFTS_01741 265.172998276242 -1.21834457478833 0.244664690679697 -4.97965019555406 6.36993016887611e-07 8.20499813462487e-06 612 hypothetical protein NA K15707 NA Folding, sorting and degradation 04122 Sulfur relay system NA LFTS_00331 953.683085694394 -0.722140208641766 0.145922889197499 -4.94877954112044 7.46802756725204e-07 9.56985388257143e-06 234 hypothetical protein NA NA NA NA NA NA NA LFTS_01646 2253.95978563075 0.748318818075056 0.151375612778032 4.94345690393569 7.67493223653251e-07 9.78455463590759e-06 486 small subunit ribosomal protein S5 NA K02988 Translation Translation 03010 Ribosome COG0098 J LFTS_02499 1020.84506740253 0.716304378982623 0.145111382161413 4.93623841433645 7.96437379111682e-07 1.01017516554676e-05 765 chromosome partitioning protein NA K03496 NA Folding, sorting and degradation 04122 Sulfur relay system COG1192 N LFTS_02492 685.616276435893 0.927642544770205 0.188195842695312 4.92913409501851 8.25948712734737e-07 1.0422885786084e-05 234 TusA-related sulfurtransferase NA K04085 Folding, sorting and degradation Folding, sorting and degradation 04122 Sulfur relay system COG0425 O LFTS_01056 335.135546663757 -1.00454746898394 0.204663926232661 -4.90827810975334 9.18795030420843e-07 1.15359820486172e-05 270 hypothetical protein NA NA NA NA NA NA NA LFTS_00181 560.523455848314 -1.20312282326752 0.24537193471828 -4.90326175505306 9.42582467561168e-07 1.1775175951543e-05 1020 ABC-type molybdate transport system%2C substrate-binding protein NA K02020 Membrane transport Membrane transport 02010 ABC transporters COG0725 P LFTS_01729 2072.1887822591 -0.958318087352127 0.196078808914058 -4.88741283496965 1.0216970559857e-06 1.26996944059022e-05 393 ribonuclease NA NA NA NA NA NA NA LFTS_02539 3695.31950328385 -0.992319195391598 0.203222626720104 -4.88291688483245 1.04527938428271e-06 1.29281818374469e-05 654 phosphatidylserine decarboxylase NA K01613 Lipid metabolism Lipid metabolism 00564 Glycerophospholipid metabolism COG0688 I LFTS_00651 1024.50488885335 0.901157619617361 0.184651669070274 4.88031125932797 1.05918538499022e-06 1.30353211241866e-05 243 NIL domain-containing protein NA NA NA NA NA NA NA LFTS_01500 731.672484922134 0.683776437757431 0.140399300010918 4.87022682950883 1.11470210206275e-06 1.36509823927487e-05 915 phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein NA K02067 Membrane transport Membrane transport 02010 ABC transporters COG1463 M LFTS_00437 7549.75504251901 -0.809778113892457 0.166487051573244 -4.86391047375961 1.15088985376928e-06 1.40250596885805e-05 717 PEGA domain-containing protein NA K07286 NA Overview 01210 2-Oxocarboxylic acid metabolism COG3056 S LFTS_00697 313.2973599879 0.905063592500318 0.186386519451924 4.85584255321516 1.19875925318863e-06 1.45371487972045e-05 303 NADH-quinone oxidoreductase subunit K NADH dehydrogenase K00340 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG0713 C LFTS_02503 783.142560746922 0.722723418454446 0.149257326799612 4.84213025886997 1.28454508108922e-06 1.55018401533389e-05 1536 protein translocase subunit yidC NA K03217 Cellular community - prokaryotes; Folding, sorting and degradation; Membrane transport Folding, sorting and degradation 03060 Protein export COG0706 M LFTS_01730 2045.13446562275 -0.877478346739456 0.181976137224308 -4.8219418222833 1.42167414329594e-06 1.70738257016122e-05 429 toxin-antitoxin system PIN domain toxin NA K07064 NA Cell growth and death 04112 Cell cycle - Caulobacter COG1848 R LFTS_00579 14986.9158597943 0.736328878493669 0.15306952441194 4.81042115550097 1.50612606643604e-06 1.80011028901923e-05 987 succinyl-CoA synthetase alpha subunit Reductive TCA cycle carbon dioxide fixation K15233 Overview; Energy metabolism Overview 01200 Carbon metabolism NA LFTS_00896 1693.30872062595 0.65354051740654 0.136688513945374 4.78123946586851 1.7421768382327e-06 2.06312242800297e-05 672 Cell division and transport-associated protein TolQ (TC 2.C.1.2.1) NA K03562 NA Membrane transport 02010 ABC transporters COG0811 U LFTS_00125 1147.81506869422 0.805122144068388 0.168394390850126 4.78116961024529 1.74278242108055e-06 2.06312242800297e-05 699 peptidoglycan-associated lipoprotein NA K03640 NA Signal transduction 04014 Ras signaling pathway COG2885 M LFTS_00347 510.797037182559 1.26847955761851 0.265682288883841 4.77442272477975 1.80223467178635e-06 2.12339118201937e-05 918 ectoine hydroxylase NA K10674 Amino acid metabolism Amino acid metabolism 00260 Glycine, serine and threonine metabolism NA LFTS_00536 45.7927729388228 -1.70749198144498 0.358439299719744 -4.7636851840187 1.90088996943207e-06 2.2290624830227e-05 831 exosortase Extracellular polysaccharide production and export NA NA NA NA NA NA LFTS_02133 1722.23176206906 0.655970645063918 0.137916377065343 4.75629261021792 1.97180605795361e-06 2.30136613148952e-05 999 hypothetical protein NA K14829 NA Translation 03010 Ribosome COG2319 R LFTS_01687 1976.64640035593 0.590011697613513 0.12417920650608 4.75129221883558 2.02120785163258e-06 2.34800127063485e-05 423 single-strand DNA-binding protein NA K03111 Replication and repair Replication and repair 03030 DNA replication COG0629 L LFTS_00689 3587.95620470187 0.564866226786197 0.118929250688468 4.74959880362694 2.03820597296275e-06 2.35673490641181e-05 555 NADH dehydrogenase subunit C NADH dehydrogenase K00332 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG0852 C LFTS_00785 1077.21218720186 -0.616485856524347 0.129867078112474 -4.74705264401521 2.06402244205317e-06 2.37553694025193e-05 3081 ATP-dependent Clp protease ATP-binding subunit ClpC Chaperones K13525 Folding, sorting and degradation; Infectious diseases Folding, sorting and degradation 04141 Protein processing in endoplasmic reticulum COG0464 MDT LFTS_01275 416.623601331298 1.2571165996161 0.265051193603166 4.7429199715216 2.10659506002125e-06 2.41336189825475e-05 294 TM2 domain-containing membrane protein YozV NA K15771 Membrane transport Membrane transport 02010 ABC transporters COG1175 G LFTS_01971 19622.9051985691 0.512613156541595 0.108194334417309 4.73789278618259 2.15952005645132e-06 2.46264534877889e-05 333 hypothetical protein NA K00406 Energy metabolism; Signal transduction Energy metabolism 00190 Oxidative phosphorylation COG2010 C LFTS_00031 362.663031146466 -0.914682959285657 0.193448102009443 -4.72831188202098 2.26394245278911e-06 2.56993650120261e-05 1128 sulfide:quinone oxidoreductase NA K03885 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG1252 C LFTS_00645 3287.34164932771 0.730832440002633 0.154878821468814 4.71873709440507 2.37313274601944e-06 2.68164000300196e-05 1257 adenosylhomocysteinase NA K01251 Amino acid metabolism Amino acid metabolism 00270 Cysteine and methionine metabolism COG0499 H LFTS_00535 51.1803264084761 -1.81260228129865 0.387698043340591 -4.67529385931485 2.93532996963051e-06 3.30191416493278e-05 714 EpsI family protein Extracellular polysaccharide production and export NA NA NA NA NA NA LFTS_00698 2830.15696781886 0.761137005703267 0.162992368132102 4.6697708268548 3.0153593244639e-06 3.37665913541318e-05 1920 NADH-quinone oxidoreductase subunit L NADH dehydrogenase K00341 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG1009 CP LFTS_00571 40.3034308424254 -1.68106256050062 0.360499729787605 -4.66314513326001 3.11412965163479e-06 3.47162614975968e-05 513 hypothetical protein NA NA NA NA NA NA NA LFTS_00325 232.392344948753 -0.931000924737815 0.200095748016856 -4.65277715276282 3.27494119736522e-06 3.6162779538523e-05 1419 Outer membrane protein TolC NA K12340 Drug resistance; Signal transduction; Membrane transport; Infectious diseases; Environmental adaptation Membrane transport 03070 Bacterial secretion system COG1538 M LFTS_00061 593.248335471479 0.75525896858833 0.162332534923218 4.65254219645841 3.27867617753083e-06 3.6162779538523e-05 270 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter ATP synthase K02116 NA Energy metabolism 00190 Oxidative phosphorylation COG3312 C LFTS_00795 680.757629162665 0.765842869032387 0.164627060355551 4.65198654084187 3.287525412593e-06 3.6162779538523e-05 318 hypothetical protein NA K00074 Amino acid metabolism; Carbohydrate metabolism; Xenobiotics biodegradation and metabolism Carbohydrate metabolism 00650 Butanoate metabolism COG1250 I LFTS_00942 1367.8230102331 -0.806227038643965 0.174202490319289 -4.62810283117229 3.69030777772381e-06 4.04145600679356e-05 1584 MFS transporter%2C DHA2 family%2C multidrug resistance protein NA K03446 NA Folding, sorting and degradation 03018 RNA degradation COG0477 GEPR LFTS_00646 1062.4785392436 0.823894823839954 0.178164153409609 4.62435797590426 3.75760441188892e-06 4.09710726664731e-05 231 sulfur carrier protein NA K03154 Folding, sorting and degradation Folding, sorting and degradation 04122 Sulfur relay system COG2104 H LFTS_02054 676.906881919202 -0.763981090903431 0.165845968598951 -4.60657016481897 4.09364972338168e-06 4.44402323682396e-05 336 small multidrug resistance family-3 protein NA K09771 NA Membrane transport 02010 ABC transporters COG1742 R LFTS_00546 57.0299030171272 -1.4283601199633 0.310678196805304 -4.59755507354907 4.27477652404299e-06 4.62047584294386e-05 1185 Glycosyltransferase involved in cell wall bisynthesis Extracellular polysaccharide production and export K13668 NA Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG0438 M LFTS_00741 807.327184337948 -1.02216439839895 0.222668793767587 -4.590514822952 4.42154053646718e-06 4.75841981543611e-05 819 Cytochrome c Cytochrome c K03889 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG2010 C LFTS_01293 919.117884168929 0.635982585503197 0.138864862270519 4.5798668943642 4.65271936661615e-06 4.96472760976869e-05 522 3-hydroxyacyl-[acyl-carrier-protein] dehydratase Lipopolysaccharide synthesis K02372 Lipid metabolism; Overview; Metabolism of cofactors and vitamins Overview 01212 Fatty acid metabolism COG0764 I LFTS_02008 1626.11124204208 -0.739252637930887 0.161414300019015 -4.57984601019736 4.65318396249439e-06 4.96472760976869e-05 1161 LPP20 lipoprotein NA K07009 NA Membrane transport 02060 Phosphotransferase system (PTS) COG3442 R LFTS_00076 5414.18976789131 -0.966526589951015 0.211328903393408 -4.57356553898232 4.79493597290045e-06 5.09410719172244e-05 498 Heavy-metal resistance Metal tolerance K08317 NA Replication and repair 03430 Mismatch repair COG0371 C LFTS_00742 148.868571387682 -1.14230422041693 0.250455323120743 -4.56091013033184 5.09323776412358e-06 5.38799535387711e-05 2211 DNA polymerase-2 NA K02319 Replication and repair; Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0417 L LFTS_02024 211.406573772029 -0.877826201788648 0.192701942390038 -4.55535730933051 5.2296606063223e-06 5.50887129971069e-05 981 ISXO2-like transposase domain-containing protein NA K07489 NA Folding, sorting and degradation 04122 Sulfur relay system COG3677 X LFTS_00649 3279.97138774405 0.64981111039615 0.143658757158525 4.52329620030818 6.08839422190696e-06 6.38639157622814e-05 1281 threonine synthase NA K01733 Metabolism of cofactors and vitamins; Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG0498 E LFTS_00324 81.0781499954869 -1.49101222912895 0.329937876978287 -4.51906959814459 6.21119761804406e-06 6.48783078926787e-05 339 ArsR family transcriptional regulator Arsenic resistance K03892 NA Signal transduction 02020 Two-component system COG0640 K LFTS_01387 824.218309158882 -0.654813860207681 0.14591492065416 -4.48764154667695 7.2015963934479e-06 7.49086553728514e-05 1452 outer membrane protein NA K12340 Drug resistance; Signal transduction; Membrane transport; Infectious diseases; Environmental adaptation Membrane transport 03070 Bacterial secretion system COG1538 M LFTS_01503 1974.40710606341 0.537668997726667 0.119923672783096 4.48342671008032 7.3453838154989e-06 7.60859340222095e-05 702 hypothetical protein NA NA NA NA NA NA NA LFTS_00141 1477.77613862538 0.630440044289509 0.141056592686226 4.46941211526279 7.84348781892132e-06 8.09083432275452e-05 393 Peroxiredoxin family protein Oxidative stress response K07092 NA Overview 01230 Biosynthesis of amino acids COG2044 R LFTS_02325 2490.17517901811 -0.872542151510399 0.195285588823322 -4.4680314444493 7.89427038036228e-06 8.10956866346307e-05 420 hypothetical protein NA NA NA NA NA NA NA LFTS_02488 2220.23680822425 -0.633952312173689 0.14208645837032 -4.46173632198938 8.12982234509882e-06 8.31717627568546e-05 897 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase Lipopolysaccharide synthesis K02535 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG0774 M LFTS_00650 938.518477610763 0.620770228789511 0.139244741825826 4.45812330612816 8.26803387671375e-06 8.42390664652065e-05 282 molybdopterin synthase sulfur carrier subunit NA K03636 Folding, sorting and degradation Folding, sorting and degradation 04122 Sulfur relay system COG1977 H LFTS_00812 755.269930586192 -0.600980532861209 0.13507486340043 -4.4492403525858 8.61745376590659e-06 8.74407757634441e-05 768 pyridoxine 5-phosphate synthase NA K03474 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00750 Vitamin B6 metabolism COG0854 H LFTS_00549 32.0711094340307 -1.6437444623383 0.371887595672793 -4.42000346735028 9.86993176010756e-06 9.94128317131236e-05 1515 putative phosphohydrolase or phosphomutase%2C AlkP superfamily NA NA NA NA NA NA NA LFTS_00820 806.534201663659 0.658782080795524 0.149051041502144 4.41984218396789 9.87730065693545e-06 9.94128317131236e-05 798 Enoyl-[acyl-carrier-protein] reductase [NADH] NA K00208 Lipid metabolism; Overview; Metabolism of cofactors and vitamins Overview 01212 Fatty acid metabolism COG0623 I LFTS_00407 452.786734640633 -0.806342893313574 0.182653989277284 -4.41459229280494 1.01200534817787e-05 0.000101445374821379 672 putative phosphoribosyltransferase NA K07100 NA Cellular community - prokaryotes 02024 Quorum sensing COG1926 R LFTS_01635 310.249914264795 0.752746005879507 0.170829601223552 4.40641434791178 1.05095838146852e-05 0.000104927009491195 867 dTDP-4-dehydrorhamnose reductase Lipopolysaccharide synthesis K00067 Biosynthesis of other secondary metabolites; Metabolism of terpenoids and polyketides Metabolism of terpenoids and polyketides 00523 Polyketide sugar unit biosynthesis COG1091 M LFTS_02040 167.958752322389 -1.04820019736788 0.237978292939332 -4.4046042368877 1.05977174141034e-05 0.000105383701965844 228 hypothetical protein NA NA NA NA NA NA NA LFTS_01810 753.764676047211 1.05705829985131 0.240234797441802 4.40010486036013 1.08198580689307e-05 0.000107164012587098 1188 hypothetical protein Lipopolysaccharide synthesis NA NA NA NA NA NA LFTS_01367 1793.84258825405 -0.552502979781768 0.125612277456858 -4.39847912137033 1.0901211148721e-05 0.000107195337674701 1779 NAD+ synthase (glutamine-hydrolysing) NA K01950 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00760 Nicotinate and nicotinamide metabolism COG0171;COG0388 HR LFTS_00474 627.342286569728 -0.687736102095858 0.156363400874062 -4.3983189048809 1.09092600288412e-05 0.000107195337674701 1353 MoxR-like ATPase NA K04748 NA Translation 00970 Aminoacyl-tRNA biosynthesis COG0714 R LFTS_00242 763.48683877247 -0.665696151433776 0.151400446962782 -4.39692329044062 1.09796126338142e-05 0.000107461877982921 528 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase NA K00950 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG0801 H LFTS_00548 20.4153958854103 -1.76725916149599 0.402422666113805 -4.39154975678286 1.12545572412015e-05 0.000109720899222067 798 Polysaccharide deacetylase Extracellular polysaccharide production and export K11931 Cellular community - prokaryotes Cellular community - prokaryotes 02026 Biofilm formation - Escherichia coli COG0726 GM LFTS_00876 2998.48947737399 0.49510929461557 0.112779187713709 4.3900767921153 1.13310638711227e-05 0.00011003525306098 963 malate dehydrogenase (NAD) Reductive TCA cycle carbon dioxide fixation K00024 Carbohydrate metabolism; Overview; Amino acid metabolism; Energy metabolism Overview 01200 Carbon metabolism COG0039 C LFTS_00326 170.79199378045 -0.912123309562673 0.207850678148862 -4.38835859322726 1.14209354778019e-05 0.000110476442014846 1050 RND family efflux transporter%2C MFP subunit Cadmium/cobalt/zinc resistance K15727 NA Transport and catabolism 04146 Peroxisome COG0845 MV LFTS_00966 4003.23788457865 0.563820837512912 0.128517038556125 4.38712908301793 1.14856631135311e-05 0.000110671932171466 351 putative isocitrate dehydrogenase (NADP) Reductive TCA cycle carbon dioxide fixation; Oxidative stress response NA NA NA NA NA NA LFTS_00480 1239.24398989523 0.657623993790539 0.150096531358987 4.3813403803296 1.17951438225786e-05 0.000113215164258418 621 hypothetical protein NA NA NA NA NA NA NA LFTS_01496 184.970117728871 -1.12828267690804 0.25761687078604 -4.37969250020554 1.1884689495777e-05 0.000113635915717314 399 Sel1 repeat protein NA K07126 NA Overview 01200 Carbon metabolism COG0790 T LFTS_01650 3588.72712299578 0.704893877645401 0.161000075435966 4.37822079111854 1.19652102174152e-05 0.000113967481227947 681 large subunit ribosomal protein L5 NA K02931 Translation Translation 03010 Ribosome COG0094 J LFTS_00002 1447.61361002124 -0.598506928811919 0.136819716943924 -4.37442016531301 1.21755670739324e-05 0.000115528472312198 1164 DNA polymerase-3 subunit beta NA K02338 Replication and repair; Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0592 L LFTS_02212 367.46981257488 0.940551830448217 0.215280116257242 4.36896749593138 1.24835343255736e-05 0.00011800025221816 441 hypothetical protein NA NA NA NA NA NA NA LFTS_00759 830.528823685992 -0.711639537329259 0.162994592170418 -4.3660315833375 1.2652419310797e-05 0.000119143615176672 879 high-affinity iron transporter NA K07243 NA Membrane transport 03070 Bacterial secretion system COG0672 P LFTS_00552 112.08200799796 -1.08638832130739 0.248952450721668 -4.3638386292569 1.27799864887438e-05 0.000119626760921329 1983 tyrosine-protein kinase Etk/Wzc Extracellular polysaccharide production and export K00903 NA Signal transduction 02020 Two-component system COG0489 D LFTS_01462 995.270595030301 -0.613944767612295 0.140700168142119 -4.36349704281917 1.27999671782275e-05 0.000119626760921329 879 3-hydroxyisobutyrate dehydrogenase NA K00020 Amino acid metabolism Amino acid metabolism 00280 Valine, leucine and isoleucine degradation COG2084 I LFTS_00703 474.876763444098 0.753844336179079 0.173191667905612 4.35265937036831 1.34496034904157e-05 0.000125227394296529 1518 ammonium transporter%2C Amt family Ammonia & glutamate conversion to glutamine K03320 NA Signal transduction 02020 Two-component system COG0004 P LFTS_00585 3730.53067762184 0.57871161097395 0.13324808888329 4.34311377989694 1.40477332147683e-05 0.000130062978941386 1623 succinate dehydrogenase / fumarate reductase flavoprotein subunit Reductive TCA cycle carbon dioxide fixation; Succinate dehydrogenase / fumarate reductase K00239 Carbohydrate metabolism; Overview; Energy metabolism; Infectious diseases Overview 01200 Carbon metabolism COG1053 C LFTS_01006 189.338187161354 0.801634974373964 0.184593257183522 4.34270994837575 1.40735886304235e-05 0.000130062978941386 1815 diguanylate cyclase (GGDEF) domain-containing protein Genes encoding proteins with EAL and GGDEF domains K14051 Cellular community - prokaryotes Cellular community - prokaryotes 02024 Quorum sensing COG2199;COG2200;COG2202 T LFTS_00230 213.733685416729 -1.01170552858098 0.233605007856069 -4.33083835773043 1.4854269892546e-05 0.000136769314640257 786 chemotaxis protein MotB Chemotaxis K02557 Cell motility Cell motility 02030 Bacterial chemotaxis COG1360 N LFTS_01565 334.320430508597 -0.839590867960492 0.193979994650037 -4.32823430826056 1.50309515400516e-05 0.000137885407854495 816 hypothetical protein NA NA NA NA NA NA NA LFTS_02278 1977.08914874105 -0.709186042147956 0.164086123320998 -4.32203545183763 1.54596340251123e-05 0.000141296508038342 453 hypothetical protein NA NA NA NA NA NA NA LFTS_00475 510.395875528989 -0.651487184881095 0.150766996893981 -4.3211524955904 1.5521635173853e-05 0.000141343534953109 1656 hypothetical protein NA NA NA NA NA NA NA LFTS_00482 794.986225805852 0.656191811626859 0.152016299636071 4.31658850529708 1.58459162412447e-05 0.000143769882393191 1071 hypothetical protein NA NA NA NA NA NA NA LFTS_01513 624.32284971914 0.629433343141132 0.146381260908027 4.29995847307678 1.70830117240621e-05 0.000154430425985521 1425 oligopeptide transport system substrate-binding protein NA K15580 Cellular community - prokaryotes; Drug resistance; Membrane transport Membrane transport 02010 ABC transporters COG4166 E LFTS_00224 196.653993142708 -1.04822219016592 0.244091118932221 -4.29438889358766 1.75175180496074e-05 0.000157360828191212 381 two-component system%2C chemotaxis family%2C response regulator CheY Chemotaxis K03413 Signal transduction; Cell motility Signal transduction 02020 Two-component system COG0784 T LFTS_00330 3327.24137440356 0.694224132832339 0.161666167560635 4.29418315104156 1.75337688692541e-05 0.000157360828191212 348 hypothetical protein NA K07001 NA Metabolism of cofactors and vitamins 00130 Ubiquinone and other terpenoid-quinone biosynthesis COG1752 R LFTS_00356 233.156526560299 0.789109997105949 0.184916929163056 4.26737563011403 1.97785971091596e-05 0.000176797589944009 1995 AcrB/AcrD/AcrF family protein NA K03296 NA Amino acid metabolism 00260 Glycine, serine and threonine metabolism COG0841 V LFTS_00926 2533.18817235966 0.902517443061502 0.211527635537654 4.26666445151487 1.98417246960493e-05 0.000176797589944009 999 Peptidase family M23 NA K08259 NA Translation 00970 Aminoacyl-tRNA biosynthesis NA LFTS_01557 573.162959832694 -1.19737668637375 0.280727586249237 -4.26526193015706 1.99667818955729e-05 0.000177276499258551 195 DNA binding domain-containing protein%2C excisionase family NA K07450 NA Overview 01200 Carbon metabolism COG2452 X LFTS_02538 3051.87323572264 -0.592801824463936 0.139035546864687 -4.26367096639585 2.01095503253257e-05 0.000177908690778504 837 CDP-diacylglycerol---serine O-phosphatidyltransferase NA K00998 Amino acid metabolism; Lipid metabolism Lipid metabolism 00564 Glycerophospholipid metabolism COG1502 I LFTS_01942 4069.73245656146 0.808984561931236 0.190572282956721 4.24502739527425 2.18566716101456e-05 0.000192679736251141 762 hypothetical protein NA K02635 Energy metabolism Energy metabolism 00195 Photosynthesis COG1290 C LFTS_02195 339.690088311635 -0.73487360719005 0.173277134651773 -4.241030466408 2.22495929945693e-05 0.000195450488284449 447 hypothetical protein NA NA NA NA NA NA NA LFTS_00087 926.495552665395 -0.799756012691657 0.188749942367561 -4.23711924178635 2.26405911099488e-05 0.000198184892603285 891 Peptidase family M23 NA K08259 NA Overview 01200 Carbon metabolism NA LFTS_02010 999.931265120875 -0.663366413599838 0.156646446910111 -4.23480025678783 2.28754946806141e-05 0.000199538525529848 2049 putative membrane protein YccC NA K03468 NA Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG1289 S LFTS_01688 1487.13100397393 0.632310201939005 0.149687547352938 4.22420043030114 2.39790576881216e-05 0.000208433347596749 369 small subunit ribosomal protein S6 NA K02990 Translation Translation 03010 Ribosome COG0360 J LFTS_01669 1985.75369543941 0.65870552051802 0.156270634028339 4.21515868681102 2.49602619759156e-05 0.000216206311052704 426 LSU ribosomal protein L11P NA K02867 Translation Translation 03010 Ribosome COG0080 J LFTS_00358 1200.01258976457 0.689456788230437 0.163722644968339 4.21112661821317 2.54100266910979e-05 0.000219337938729408 618 hypothetical protein NA K07337 NA Membrane transport 03070 Bacterial secretion system COG3417 M LFTS_01085 435.109775971567 -0.736852349290703 0.17536658211066 -4.20178314717758 2.6482074999421e-05 0.000227800825081524 1590 putative transposase NA K07496 NA Metabolism of cofactors and vitamins 00730 Thiamine metabolism COG0675 X LFTS_01553 2571.2100477302 0.493799561362739 0.117597696300007 4.19905811847702 2.68027526994509e-05 0.000229764286933914 1500 adenine phosphoribosyltransferase NA K03087 Cellular community - prokaryotes Cellular community - prokaryotes 05111 Biofilm formation - Vibrio cholerae COG0568 K LFTS_01944 18257.2422579209 0.696572353899893 0.166087262477203 4.19401430013637 2.74060693217617e-05 0.000234128825889689 1842 NADPH-dependent glutamate synthase beta chain NA K00266 Energy metabolism; Amino acid metabolism; Overview Overview 01230 Biosynthesis of amino acids COG0493 ER LFTS_00156 537.635303117029 0.714729473379162 0.170489405788584 4.19222220919382 2.76235226267878e-05 0.000235178346747241 1623 DNA polymerase-3 subunit gamma/tau NA K02343 Replication and repair; Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG2812 L LFTS_00560 279.229923510231 -0.864051293666216 0.20656725373535 -4.18290546077173 2.87807095350002e-05 0.00024419400649833 408 MerR family transcriptional regulator%2C mercuric resistance operon regulatory protein Mercury resistance K08365 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0789 K LFTS_00404 2381.8781240781 -0.59145997798508 0.141675966515056 -4.17473755453242 2.98329773862587e-05 0.000252261162524623 567 putative kinase inhibitor NA K06910 NA Cellular community - prokaryotes 02024 Quorum sensing COG1881 R LFTS_00944 597.521871936798 -0.712073864605823 0.170914713661014 -4.16625256745375 3.09647634251137e-05 0.000260943735168924 993 membrane fusion protein%2C multidrug efflux system NA K03543 NA Folding, sorting and degradation 03018 RNA degradation COG1566 V LFTS_00758 301.130004688012 -1.01799850852725 0.244534995696156 -4.16299722511763 3.1409718624347e-05 0.000263799190878806 321 Cupredoxin-like domain-containing protein NA NA NA NA NA NA NA LFTS_00934 684.288847518054 -0.818589317974332 0.196854807048035 -4.15834050613043 3.20567937221569e-05 0.000268327236341017 114 hypothetical protein NA NA NA NA NA NA NA LFTS_00104 2378.18049896085 0.607562507588322 0.146152972931676 4.15703146779196 3.22409595812919e-05 0.000268963172882858 1083 GTP-binding protein NA K03979 NA Translation 03010 Ribosome COG0536 DL LFTS_00386 70.1866547663621 -1.24653095067724 0.301157492764634 -4.13913311348839 3.48620637400132e-05 0.000289856489824993 252 hypothetical protein NA NA NA NA NA NA NA LFTS_02016 250.055541180156 -0.750846883346639 0.181748612271518 -4.13123860458936 3.60813822826649e-05 0.000298994387849017 906 Pirin NA K06911 NA Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG1741 R LFTS_00238 93.8977755470021 1.3422450879089 0.325060657966163 4.12921420976333 3.64005151936135e-05 0.000300636813193765 450 hypothetical protein NA NA NA NA NA NA NA LFTS_00504 105.052398294949 -1.0102664729726 0.244745234775429 -4.12782898061155 3.66204301227142e-05 0.00030145162014923 636 GGDEF domain-containing protein%2C diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants Putative diguanylate cyclases (GGDEF domain-containing proteins) K13591 Cell growth and death Cell growth and death 04112 Cell cycle - Caulobacter COG3706 TK LFTS_01651 1131.81245556692 0.851547988312187 0.206614760577605 4.12142862364543 3.76530133440467e-05 0.000308928683740264 201 large subunit ribosomal protein L29 NA K02904 Translation Translation 03010 Ribosome COG0255 J LFTS_02301 148.444821727985 -0.900396385666253 0.21882301888229 -4.11472426559748 3.8764251425087e-05 0.000316999766588047 744 Putative zinc- or iron-chelating domain-containing protein NA K06940 NA Lipid metabolism 00564 Glycerophospholipid metabolism COG0727 R LFTS_00457 75.4606704122998 -1.17645178183643 0.285990505681686 -4.11360432764103 3.89528874559192e-05 0.000317497961362017 639 hypothetical protein NA NA NA NA NA NA NA LFTS_01624 542.771900171801 0.74441726036423 0.181038745821197 4.11192232351993 3.92378324068296e-05 0.000318775331252871 774 hypothetical protein NA K09778 NA Nucleotide metabolism 00230 Purine metabolism COG2121 S LFTS_00722 586.525120540175 -0.609186299932309 0.14831353445352 -4.10742217274327 4.00099528261714e-05 0.000323989389986521 1203 type II secretion system protein F (GspF) NA K02455 Cellular community - prokaryotes; Membrane transport Membrane transport 03070 Bacterial secretion system COG1459 NUW LFTS_02473 1254.30510110457 -0.639901116206483 0.155987794570072 -4.10225119196125 4.0914972919759e-05 0.000330242281423769 876 DNA-(apurinic or apyrimidinic site) lyase NA K10563 Replication and repair Replication and repair 03410 Base excision repair COG0266 L LFTS_00853 1588.45873331594 0.527531378674792 0.128738449113073 4.09769872411197 4.17277891132982e-05 0.000335712892348412 1695 DNA repair protein RecN (Recombination protein N) NA K03631 NA Immune system 04621 NOD-like receptor signaling pathway COG0497 L LFTS_02271 699.528389437889 0.720758875206051 0.176525226507067 4.08303611595817 4.44511115386765e-05 0.000356469236403709 1329 UDP-N-acetylglucosamine 1-carboxyvinyltransferase NA K00790 Carbohydrate metabolism; Glycan biosynthesis and metabolism Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG0766 M LFTS_01566 1096.87335630025 -0.589085603460844 0.14435769726678 -4.08073566297048 4.4893386824232e-05 0.00035885839114161 1431 hypothetical protein NA K04034 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG1032 R LFTS_02406 3854.5146417971 0.552693349039547 0.135906204932038 4.06672638174194 4.7678167966457e-05 0.000379897197322475 1032 rod shape-determining protein MreB NA K03569 NA Overview 01200 Carbon metabolism COG1077 D LFTS_01668 2993.880962704 0.664933761283246 0.163563250160598 4.06530049158577 4.79706151780751e-05 0.000381006227899983 699 large subunit ribosomal protein L1 NA K02863 Translation Translation 03010 Ribosome COG0081 J LFTS_00268 289.754815526251 0.982344850070006 0.241771136704291 4.06311879681281 4.84213703159104e-05 0.000383361549698577 1116 hypothetical protein NA NA NA NA NA NA NA LFTS_00173 562.68651444539 -0.733493513509189 0.180663918352608 -4.05998895738331 4.90750368173473e-05 0.000387303306437858 204 hypothetical protein NA NA NA NA NA NA NA LFTS_00581 11574.1969504001 0.842240783695786 0.208490687976453 4.03970456364416 5.3518572407326e-05 0.000421035351280419 1926 aconitase Reductive TCA cycle carbon dioxide fixation K01681 Carbohydrate metabolism; Overview; Energy metabolism Overview 01200 Carbon metabolism COG0065;COG1048 EC LFTS_01691 1787.16137929736 0.562205575540333 0.139445254227125 4.03172971827801 5.53678411246735e-05 0.000434209631028197 624 large subunit ribosomal protein L25 NA K02897 Translation Translation 03010 Ribosome COG1825 J LFTS_02273 1724.09472955033 0.503949719110872 0.125027741651553 4.03070320597614 5.56102276670329e-05 0.000434739075409572 1086 peptide chain release factor 1 NA K02835 NA Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG0216 J LFTS_02394 4593.09616363567 0.589391787385403 0.146610699188279 4.02011442990596 5.81698800387454e-05 0.00045332389271574 456 LSU ribosomal protein L13P NA K02871 Translation Translation 03010 Ribosome COG0102 J LFTS_00964 493.949337124783 0.72910221859942 0.181645476097916 4.01387490766023 5.97300098204524e-05 0.000464027513792639 1005 precorrin-8X methylmutase NA K06042 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG2082 H LFTS_00591 580.030288532329 0.658417890638779 0.164386260633038 4.00530973880218 6.19362693458041e-05 0.000479668428640713 447 MraZ protein NA K03925 NA Overview 01200 Carbon metabolism COG2001 J LFTS_01610 1111.40896679282 -0.526064123844074 0.131717702933141 -3.99387563045417 6.50019684795876e-05 0.000501847495777189 1137 3-hydroxybutyryl-CoA dehydrogenase NA K00074 Amino acid metabolism; Carbohydrate metabolism; Xenobiotics biodegradation and metabolism Carbohydrate metabolism 00650 Butanoate metabolism COG1250 I LFTS_00228 319.170893074944 -0.699424708867926 0.1752265429316 -3.99154544263849 6.56441061646054e-05 0.000505236061687954 516 purine-binding chemotaxis protein CheW Chemotaxis K03408 Signal transduction; Cell motility Signal transduction 02020 Two-component system COG0835 NT LFTS_01940 1880.5329647632 0.948228253251622 0.237715919500227 3.98891355381319 6.63766033956506e-05 0.000509297024819714 219 hypothetical protein NA NA NA NA NA NA NA LFTS_01453 1657.11222425592 0.561509520759228 0.140817998639547 3.98748403033713 6.67776978021033e-05 0.000510439183469501 411 transcriptional regulator%2C TraR/DksA family NA K06204 Cellular community - prokaryotes Cellular community - prokaryotes 02026 Biofilm formation - Escherichia coli COG1734 J LFTS_01680 863.363460672585 0.53671408471546 0.13461866797978 3.98692167119106 6.69361117502242e-05 0.000510439183469501 1452 SSU ribosomal protein S12P methylthiotransferase NA K14441 NA Replication and repair 03440 Homologous recombination COG0621 J LFTS_02036 347.302078676575 -0.733622697742258 0.18434581582683 -3.97960048321034 6.90311783235992e-05 0.000524805838876048 1017 lipoprotein NA NA NA NA NA NA NA LFTS_01020 706.874540775723 -0.777395683171523 0.195487740985573 -3.97669786991346 6.98788559808981e-05 0.000529630597464978 291 hypothetical protein NA NA NA NA NA NA NA LFTS_00779 2611.63041780652 0.469073221401496 0.118123973352764 3.97102474703132 7.15641442881961e-05 0.000539122346962047 1830 GTP-binding protein NA K06207 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG1217 T LFTS_01616 383.637596711928 -0.778734089393473 0.196104189972065 -3.97102218725875 7.1564913313546e-05 0.000539122346962047 732 hypothetical protein NA NA NA NA NA NA NA LFTS_02392 506.657715426353 0.665053081196333 0.167601293187939 3.96806652589834 7.24581091101363e-05 0.000544201991685193 1032 N-acetyl-gamma-glutamyl-phosphate reductase NA K00145 Overview; Amino acid metabolism Overview 01210 2-Oxocarboxylic acid metabolism COG0002 E LFTS_00712 1447.14576674925 -0.501306507680471 0.126495565197366 -3.96303622896426 7.40025463583432e-05 0.000554127500743497 1500 hypothetical protein NA K09930 NA Membrane transport 03070 Bacterial secretion system COG3220 S LFTS_01692 1333.41770876225 0.539275665745673 0.136474762072088 3.95146807774482 7.7673234325607e-05 0.000579866848448826 945 ribose-phosphate pyrophosphokinase NA K00948 Carbohydrate metabolism; Overview; Nucleotide metabolism Overview 01200 Carbon metabolism COG0462 FE LFTS_02255 2293.58985416484 0.520351780443359 0.13180324037897 3.9479437603143 7.88253152881395e-05 0.000586705789839266 789 Putative zinc ribbon domain protein NA K07164 NA Replication and repair 03030 DNA replication COG1579 R LFTS_01217 457.357238294692 -0.779647770715814 0.198284315831663 -3.93196893786451 8.42529542008639e-05 0.000625232370577157 1674 dihydroxyacid dehydratase NA K01687 Metabolism of cofactors and vitamins; Amino acid metabolism; Overview Overview 01210 2-Oxocarboxylic acid metabolism COG0129 EG LFTS_01769 728.864035851542 0.547124916695109 0.139533571279821 3.92109878416216 8.81461161516352e-05 0.000652176323669539 675 hypothetical protein NA NA NA NA NA NA NA LFTS_01984 2894.5488662756 -0.49472071412499 0.126197094895968 -3.92022268446684 8.84671844863026e-05 0.000652609556774327 1536 proteasome accessory factor A NA K13571 NA Folding, sorting and degradation 03050 Proteasome NA LFTS_01337 1994.88835122931 -0.631607993830916 0.16129327667314 -3.91589784062027 9.0068383985331e-05 0.000662455628957198 501 Phosphopantetheine adenylyltransferase NA K00954 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00770 Pantothenate and CoA biosynthesis COG0669 H LFTS_02259 3213.38406672016 0.531722836750292 0.135948191235302 3.91121670629642 9.18323279455071e-05 0.000673437071600386 483 Yqey-like protein NA K09117 NA Replication and repair 03030 DNA replication COG1610 S LFTS_02194 680.235242079709 0.549728371931975 0.140615650577233 3.90943945197649 9.25105385727691e-05 0.000676415290858541 456 hypothetical protein NA K07007 NA Signal transduction 02020 Two-component system COG2081 R LFTS_01880 480.009463288154 0.693883801379575 0.178310031154895 3.89144568527842 9.96486979462932e-05 0.00072647115276975 672 signal peptidase I NA K03100 Cellular community - prokaryotes; Folding, sorting and degradation Folding, sorting and degradation 03060 Protein export COG0681 U LFTS_01885 318.872945091949 -0.728095316812478 0.187341911742451 -3.88645183579331 0.000101720097359198 0.000739403982558378 948 transcriptional regulator%2C AraC family NA K07506 NA Carbohydrate metabolism 00500 Starch and sucrose metabolism COG2207 K LFTS_01277 634.459645445514 0.981109752476687 0.253038615419555 3.87731236534764 0.000105616723224503 0.00076549030302074 657 hypothetical protein NA NA NA NA NA NA NA LFTS_01938 411.200016242464 0.745098310605492 0.192803540447814 3.86454682769255 0.000111295637545573 0.000804305101564811 984 ABC-2 type transport system ATP-binding protein NA K09687 NA NA NA NA LFTS_01756 369.08177422223 -0.915841476245994 0.237793214138657 -3.85141972853761 0.000117435024271812 0.000846212957506445 1287 hypothetical protein NA NA NA NA NA NA NA LFTS_01696 648.65229298356 -0.619967085478248 0.161184369180553 -3.84632262191493 0.000119903861465771 0.000861505779202045 552 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase NA K00995 Lipid metabolism Lipid metabolism 00564 Glycerophospholipid metabolism COG0558 I LFTS_00169 1068.01172649622 0.628946079488395 0.163567168503076 3.84518534645031 0.000120461350901429 0.000863017055737617 384 transcriptional regulator%2C TraR/DksA family NA K06204 Cellular community - prokaryotes Cellular community - prokaryotes 02026 Biofilm formation - Escherichia coli COG1734 J LFTS_01009 661.201210914541 0.619373851846861 0.161840615994994 3.82706064258936 0.000129682574146798 0.000926410572784308 468 hypothetical protein NA K08326 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0006 E LFTS_02390 3392.80629664101 0.447817883797569 0.117473159487798 3.81208682689839 0.000137798450387362 0.000981567185280747 825 SSU ribosomal protein S2P NA K02967 Translation Translation 03010 Ribosome COG0052 J LFTS_02272 651.304248743482 0.613698783567364 0.161096570035359 3.80950869054917 0.000139243212507111 0.000989024646550506 882 release factor glutamine methyltransferase NA K02493 NA Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG2890 J LFTS_02309 93.7788781665111 -0.95326602542375 0.251469233664364 -3.79078590065644 0.000150171362124734 0.00106360685539056 1368 transposase%2C IS5 family NA K07481 NA Carbohydrate metabolism 00500 Starch and sucrose metabolism COG3039 X LFTS_01666 1980.14619190021 0.667156250847742 0.176812661731042 3.77323798146641 0.000161142443284268 0.00113806850569514 387 large subunit ribosomal protein L7/L12 NA K02935 Translation Translation 03010 Ribosome COG0222 J LFTS_00336 4034.45837146629 -0.56299186299618 0.149605153588606 -3.76318495380402 0.000167763033513661 0.00118146997539649 1518 proteasome accessory factor A NA K13571 NA Folding, sorting and degradation 03050 Proteasome NA LFTS_00660 691.506710581597 0.567898042254855 0.150997405453187 3.76097880987045 0.000169249768923399 0.00118857323599878 978 phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein NA K02067 Membrane transport Membrane transport 02010 ABC transporters COG1463 M LFTS_02151 1170.02475807871 0.955802655519236 0.254566855960372 3.7546233264083 0.000173602352318742 0.00121570548694195 1020 6-phosphogluconate dehydrogenase (decarboxylating) NA K00033 Carbohydrate metabolism; Metabolism of other amino acids; Overview Overview 01200 Carbon metabolism COG0362;COG1023 G LFTS_01863 509.21389573506 0.598647918595947 0.159651808514162 3.74970959720035 0.000177039471494808 0.00123629248914633 294 hypothetical protein NA NA NA NA NA NA NA LFTS_00832 870.282522440438 0.490463541230241 0.130983726105114 3.74446166569307 0.00018078097495929 0.00125888376400223 3084 hydrophobic/amphiphilic exporter-1%2C HAE1 family NA K03296 NA Immune system 04621 NOD-like receptor signaling pathway COG0841 V LFTS_00509 272.020838594131 0.682486794907304 0.182385029116971 3.74201105327344 0.000182553483718807 0.00126767586738814 324 putative membrane protein NA K00389 NA Replication and repair 03030 DNA replication COG2149 S LFTS_01504 1236.14808845351 0.546364897914472 0.146498653983808 3.72948749395922 0.000191869628454458 0.0013286570928629 276 hypothetical protein NA NA NA NA NA NA NA LFTS_02484 470.196042335877 0.581807477710382 0.156042529107093 3.72851863552586 0.000192608667687034 0.00133006985519435 798 myo-inositol-1(or 4)-monophosphatase NA K01092 Biosynthesis of other secondary metabolites; Signal transduction; Carbohydrate metabolism Carbohydrate metabolism 00562 Inositol phosphate metabolism COG0483 G LFTS_00880 2334.33793036781 0.49223053873704 0.132067875354816 3.72710272967293 0.000193693524779163 0.00133385623989197 1461 RNA polymerase%2C sigma 54 subunit%2C RpoN/SigL NA K03092 Cellular community - prokaryotes; Signal transduction Signal transduction 02020 Two-component system COG1508 K LFTS_02424 1741.5111579917 0.506184787466734 0.136066770074115 3.72012054957296 0.000199127709158274 0.00136749028996538 1590 1%2C4-alpha-glucan branching enzyme NA K16150 Carbohydrate metabolism Carbohydrate metabolism 00500 Starch and sucrose metabolism COG0438 M LFTS_02171 2890.59694731325 -0.632265920663286 0.170584978475736 -3.70645719402086 0.000210178740413827 0.00143940591919773 795 undecaprenyl diphosphate synthase NA K00806 Metabolism of terpenoids and polyketides Metabolism of terpenoids and polyketides 00900 Terpenoid backbone biosynthesis COG0020 I LFTS_01811 1238.56885953206 0.793689690218475 0.214558055434952 3.69918383446152 0.000216293896910642 0.00147721601021938 1419 alpha-1%2C2-rhamnosyltransferase Lipopolysaccharide synthesis K12993 NA Glycan biosynthesis and metabolism 00550 Peptidoglycan biosynthesis COG0438 M LFTS_00790 395.97133595555 0.717318039425044 0.194108005728332 3.69545829258059 0.0002194905106498 0.00148776926869036 510 putative rRNA maturation factor NA K07042 NA Cell growth and death 04112 Cell cycle - Caulobacter COG0319 J LFTS_01720 64.295749550155 -1.05828211832762 0.286382578933402 -3.69534390768135 0.000219589354205855 0.00148776926869036 237 hypothetical protein NA NA NA NA NA NA NA LFTS_01157 148.560682230585 -1.12093653778728 0.303341827537907 -3.69529170073719 0.000219634481741497 0.00148776926869036 1653 mercuric reductase Mercury resistance K00520 NA Signal transduction 02020 Two-component system COG1249 C LFTS_02388 1356.91980577009 0.505473256452007 0.137258823672478 3.68262850378312 0.000230841438879994 0.00155943428547735 711 uridylate kinase NA K09903 Nucleotide metabolism Nucleotide metabolism 00240 Pyrimidine metabolism COG0528 F LFTS_02269 1069.3004543105 0.462460303632279 0.125752628355776 3.67753986281621 0.000235494281995813 0.00158655497301244 1338 histidinol dehydrogenase NA K00013 Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG0141 E LFTS_01346 336.014828529383 0.690749214750816 0.187903143523484 3.67609185135579 0.000236834280912033 0.00159127033066842 1137 lipopolysaccharide export system permease protein Lipopolysaccharide synthesis K07091 Membrane transport Membrane transport 02010 ABC transporters COG0795 MN LFTS_01216 413.302129172979 -0.838633647427125 0.228260025593583 -3.67402765879081 0.000238756870815622 0.00159986409931978 1017 translation factor SUA5 NA K07566 NA Overview 01210 2-Oxocarboxylic acid metabolism COG0009 J LFTS_02387 1250.30554123856 0.500728735934791 0.136739070508046 3.66192876750122 0.000250323470636018 0.0016728606129063 555 ribosome recycling factor NA K02838 NA Metabolism of other amino acids 00473 D-Alanine metabolism COG0233 J LFTS_01708 1274.5298255763 0.629833932122561 0.172071944608129 3.66029414938573 0.000251925876172147 0.0016751050164607 1035 glucokinase NA K00845 Overview; Biosynthesis of other secondary metabolites; Carbohydrate metabolism Overview 01200 Carbon metabolism COG0837 G LFTS_02249 100406.57768589 -1.55250892267313 0.424158231125426 -3.66021170579157 0.000252006949379044 0.0016751050164607 459 HSP20 family protein NA K13993 Folding, sorting and degradation Folding, sorting and degradation 04141 Protein processing in endoplasmic reticulum COG0071 O LFTS_01024 185.08132327015 0.684880684066692 0.187896889471841 3.64498148953834 0.00026741104795566 0.00177275697391406 729 hypothetical protein NA NA NA NA NA NA NA LFTS_00440 217.934514494868 0.736712162733268 0.202737154593158 3.6338290542336 0.000279245913773175 0.00184516039633192 1140 cytochrome d ubiquinol oxidase subunit II Cytochrome bd K00426 Energy metabolism; Signal transduction Energy metabolism 00190 Oxidative phosphorylation COG1294 C LFTS_00073 460.756776558435 0.710358134496817 0.195513098074206 3.63330202167429 0.000279817163884607 0.00184516039633192 558 hypothetical protein NA K07337 NA Carbohydrate metabolism 00620 Pyruvate metabolism COG3417 M LFTS_02322 1029.04894890014 0.504019154747229 0.138806473429449 3.63109257295125 0.000282223922431562 0.00185610759567424 549 inorganic pyrophosphatase NA K01507 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG0221 CP LFTS_01660 2855.53625857283 0.562060129036813 0.154997939435379 3.6262425880258 0.000287575210237428 0.00188267116899939 1200 translation elongation factor 1A (EF-1A/EF-Tu) NA K02358 NA Membrane transport 03070 Bacterial secretion system COG0050 J LFTS_02056 1715.33856650815 -0.628874841751835 0.173431960535847 -3.62606084719807 0.000287777572091621 0.00188267116899939 222 putative addiction module component NA NA NA NA NA NA NA LFTS_00781 759.053365552597 0.57354767779902 0.158986055292653 3.60753448938188 0.000309120457971736 0.00201699070477096 789 phosphoribosyl 1%2C2-cyclic phosphate phosphodiesterase NA K06167 Metabolism of other amino acids Metabolism of other amino acids 00440 Phosphonate and phosphinate metabolism COG1235 P LFTS_00438 548.642857840875 -0.550767765360585 0.152736102478683 -3.6060090340295 0.000310942315822211 0.00202356700820423 1365 Transcriptional regulator containing PAS%2C AAA-type ATPase%2C and DNA-binding Fis domains NA K02481 NA Overview 01230 Biosynthesis of amino acids COG2204 T LFTS_00559 237.566699511332 -0.783166241248864 0.217255614843334 -3.60481473315945 0.000312375685632101 0.00202758734851541 1674 mercuric reductase Mercury resistance K00520 NA Cellular community - prokaryotes 02026 Biofilm formation - Escherichia coli COG1249 C LFTS_00074 497.807543619349 0.550998766841062 0.15317634756721 3.59715305654026 0.000321719191387149 0.00208279664007409 669 DNA-binding response regulator%2C OmpR family%2C contains REC and winged-helix (wHTH) domain NA K02483 NA Replication and repair 03430 Mismatch repair COG0745 TK LFTS_01833 508.221154017944 -0.664676614197944 0.185504314258636 -3.58307900737678 0.000339567845426977 0.0021926380876142 381 hypothetical protein NA NA NA NA NA NA NA LFTS_00694 2814.27226075105 0.433050502584724 0.121175154634007 3.57375655011701 0.000351896128047224 0.00226635692830415 1014 NADH dehydrogenase subunit H NADH dehydrogenase K00337 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG1005 C LFTS_01475 635.836814099965 0.506115644324115 0.141648816971443 3.57303121300442 0.000352872680825835 0.00226677386184244 1164 hypothetical protein NA K12571 Folding, sorting and degradation Folding, sorting and degradation 03018 RNA degradation NA LFTS_02389 1977.98375328049 0.494026849423831 0.138558923241947 3.56546397637039 0.000363213051315202 0.00232718465352988 597 translation elongation factor Ts (EF-Ts) NA K02357 NA Nucleotide metabolism 00240 Pyrimidine metabolism COG0264 J LFTS_00708 242.231077144186 0.658816171439742 0.184859444906429 3.56387617507571 0.000365418385394746 0.00233529590254843 474 hypothetical protein NA K02503 NA Translation 03010 Ribosome COG0537 FGR LFTS_01987 2195.39498839768 -0.517573253472937 0.145577488948452 -3.55531103889425 0.000377532197624027 0.00240351554862086 750 cob(II)yrinic acid a%2Cc-diamide reductase NA K04719 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00740 Riboflavin metabolism COG0778 C LFTS_00086 946.121353641842 -0.652486264101363 0.183542152712114 -3.55496682620252 0.000378026781782283 0.00240351554862086 648 thiamine-phosphate pyrophosphorylase NA K00788 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00730 Thiamine metabolism COG0352 H LFTS_00673 596.329500608128 0.634791052240029 0.178605277348401 3.55415619103885 0.000379193941609667 0.00240478606847355 276 hypothetical protein NA K05589 NA Energy metabolism 00190 Oxidative phosphorylation COG2919 D LFTS_01422 128.627113145163 0.775776907809032 0.218624010626839 3.54845245764509 0.000387501945763831 0.00245122095971726 444 hypothetical protein NA NA NA NA NA NA NA LFTS_02099 963.974634857161 -0.562921665990525 0.158726553076288 -3.54648705639043 0.000390403920293806 0.00246331001484873 684 hypothetical protein NA NA NA NA NA NA NA LFTS_01858 1051.04361221396 -0.52061554343669 0.146975036537126 -3.54220387150701 0.000396798669679968 0.00249732023499848 1167 small ribosomal subunit Rsm22 NA K02493 NA Biosynthesis of other secondary metabolites 00965 Betalain biosynthesis COG2890 J LFTS_00994 5125.6880491013 -0.457046513914824 0.129066905910328 -3.54115960781122 0.000398372514755727 0.00250089412041095 1230 transposase%2C IS605 OrfB family%2C central region NA K07496 NA Replication and repair 03430 Mismatch repair COG0675 X LFTS_01620 1256.74257420648 -0.614754807129193 0.1738338986498 -3.53644951821312 0.000405543999003013 0.00253950222045715 1131 membrane fusion protein%2C multidrug efflux system Cadmium/cobalt/zinc resistance K15727 NA Nucleotide metabolism 00230 Purine metabolism COG0845 MV LFTS_02182 460.604076634864 0.534114877964009 0.151207707609417 3.53232574191044 0.000411921609080492 0.00257295758837714 645 putative lysine decarboxylase NA K06966 NA Amino acid metabolism 00330 Arginine and proline metabolism COG1611 R LFTS_00945 476.765710348825 -0.737442241607373 0.208813862292571 -3.53157703952688 0.000413089512456532 0.00257378578437829 1623 MFS transporter%2C DHA2 family%2C multidrug resistance protein NA K03446 NA Folding, sorting and degradation 03018 RNA degradation COG0477 GEPR LFTS_02382 6563.19856106598 0.384464210237886 0.108957844287105 3.52855925843043 0.000417828386350138 0.00259680342116611 1539 cytochrome c biogenesis protein Cytochrome c K07399 NA Nucleotide metabolism 00240 Pyrimidine metabolism COG1333 CO LFTS_02183 882.211151994241 0.455850396785254 0.12926168703829 3.52657007060586 0.000420979752347994 0.0026098644995938 1359 microcin-processing peptidase 1. Unknown type peptidase. MEROPS family U62 NA K03592 NA Amino acid metabolism 00330 Arginine and proline metabolism COG0312 R LFTS_02120 1277.98294453192 0.491982844117923 0.139554117820924 3.52539109415057 0.000422858004627876 0.00261498756095746 561 1%2C2-dihydroxy-3-keto-5-methylthiopentene dioxygenase NA K08967 Amino acid metabolism Amino acid metabolism 00270 Cysteine and methionine metabolism COG1791 E LFTS_01739 83.2190942357666 -0.916559705885201 0.260070183602152 -3.52427830514907 0.000424637988251068 0.00261947900444704 1092 Putative MetA-pathway of phenol degradation NA NA NA NA NA NA NA LFTS_00067 1152.17112396868 0.668542317316619 0.189998543881942 3.51867074166646 0.000433714625367823 0.00266251306727617 876 F-type H+-transporting ATPase subunit gamma ATP synthase K02115 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG0224 C LFTS_00575 1150.65812458835 -0.512316401559582 0.14560046612288 -3.51864533955002 0.000433756151346279 0.00266251306727617 2244 PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein NA K14051 Cellular community - prokaryotes Cellular community - prokaryotes 02024 Quorum sensing COG2199;COG2200;COG2202 T LFTS_00911 59.6489490996502 -1.08893315564639 0.309581652374173 -3.51743440638486 0.000435740029556067 0.00266810274255267 1353 hypothetical protein NA NA NA NA NA NA NA LFTS_00254 2698.93908173271 -0.447122243965336 0.127433768829373 -3.508663740174 0.000450363914546789 0.00275087147804255 2553 DNA topoisomerase-1 NA K03168 NA Cellular community - prokaryotes 02024 Quorum sensing COG0550;COG0551;COG1754 LS LFTS_01973 8158.16227091404 0.456126447439761 0.130138930668791 3.50491928199887 0.000456745739519304 0.00278301448148282 201 hypothetical protein NA NA NA NA NA NA NA LFTS_01690 1781.34455417282 0.568278278490152 0.162624935114428 3.49441048563858 0.000475109904064524 0.00288783183741909 564 peptidyl-tRNA hydrolase%2C PTH1 family NA K01056 NA Translation 03010 Ribosome COG0193 J LFTS_00520 379.699120592964 -0.604488288744908 0.173086878409044 -3.49239811995663 0.000478704170760873 0.00289927405864641 1518 Lactonase%2C 7-bladed beta-propeller NA K07404 Carbohydrate metabolism; Overview Overview 01200 Carbon metabolism COG2706 G LFTS_01291 1513.50496216614 0.496462542611394 0.14216928579539 3.49205202680629 0.000479324874538888 0.00289927405864641 603 periplasmic chaperone for outer membrane proteins Skp NA K06142 NA Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG2825 MO LFTS_01384 189.254552144093 -0.70630703272644 0.202353796462982 -3.49045604813078 0.000482196921132567 0.00290286800498188 1137 ABC-2 type transport system permease protein NA K09686 NA NA NA NA LFTS_00875 1615.37355641051 0.463214465567569 0.132710077827927 3.49042418743946 0.00048225441917036 0.00290286800498188 1374 outer membrane protein NA K12340 Drug resistance; Signal transduction; Membrane transport; Infectious diseases; Environmental adaptation Membrane transport 03070 Bacterial secretion system COG1538 M LFTS_02465 1079.41022003388 0.509130564618732 0.145930916947369 3.48884647111724 0.000485109688445688 0.00291300165573908 870 peptidyl-prolyl cis-trans isomerase C NA K03769 NA Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG0760 O LFTS_01204 41.94323966099 -1.33016541426507 0.381384794806122 -3.48772534296041 0.000487148221968198 0.00291637554696628 1122 sulfoxide reductase catalytic subunit YedY NA K07147 NA Translation 00970 Aminoacyl-tRNA biosynthesis COG2041 C LFTS_02496 1273.82888708152 0.558666581896146 0.160202690376409 3.48724843873416 0.000488017790642789 0.00291637554696628 1104 tRNA-specific 2-thiouridylase NA K00566 Folding, sorting and degradation Folding, sorting and degradation 04122 Sulfur relay system COG0482 J LFTS_00351 224.279935995695 0.802627712654228 0.230594550717248 3.480688117554 0.000500127480902411 0.00298157534178272 1464 MFS transporter%2C MHS family%2C proline/betaine transporter NA K03762 NA Membrane transport 03070 Bacterial secretion system COG0477 GEPR LFTS_00137 677.635661382927 -0.527867346685389 0.151697370265668 -3.47973960102891 0.000501901351650611 0.00298499224929048 1389 dihydrolipoamide dehydrogenase NA K00382 Carbohydrate metabolism; Amino acid metabolism; Overview Overview 01200 Carbon metabolism COG1249 C LFTS_00517 2663.47890827178 -0.449427125864727 0.12919470309118 -3.47868074395853 0.000503888504377827 0.00298965828611761 1131 two-component system%2C response regulator RpfG Quorum sensing K13815 Cellular community - prokaryotes; Signal transduction Signal transduction 02020 Two-component system COG3437 T LFTS_02258 3824.30033679727 0.447994964446934 0.128829866244413 3.47741542785591 0.000506272737181815 0.00299665243960474 1386 DNA primase NA K02316 Replication and repair Replication and repair 03030 DNA replication COG0358 L LFTS_01381 65.5012360899508 -1.0763645086389 0.310000663353981 -3.47213614639858 0.00051633440966683 0.00304341063452166 414 outer membrane transport energization protein ExbD NA K03559 NA Membrane transport 03070 Bacterial secretion system COG0848 U LFTS_01452 1163.22772077965 0.577885888509273 0.166442397366282 3.47198729202119 0.00051662079153988 0.00304341063452166 678 endonuclease-3 NA K10773 Replication and repair Replication and repair 03410 Base excision repair COG0177 L LFTS_01652 2784.85148361825 0.642183610966305 0.185209933921726 3.46732811447201 0.000525659809743762 0.00308933874000708 681 SSU ribosomal protein S3P NA K02982 Translation Translation 03010 Ribosome COG0092 J LFTS_00349 900.746171256569 1.41205290942469 0.408193769301112 3.45927110019914 0.000541639437235406 0.00316902666246981 1278 diaminobutyrate-2-oxoglutarate transaminase NA K00836 Overview; Amino acid metabolism Overview 01210 2-Oxocarboxylic acid metabolism COG0160;COG4992 E LFTS_01908 2053.09697200372 0.45332401849272 0.131048538921999 3.459206964242 0.000541768435860688 0.00316902666246981 3474 PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein Genes encoding proteins with EAL and GGDEF domains K14051 Cellular community - prokaryotes Cellular community - prokaryotes 02024 Quorum sensing COG2199;COG2200;COG2202 T LFTS_00757 533.534690448347 -0.603515195246165 0.174571574347568 -3.45712179947797 0.000545978017801722 0.00318615340904949 1689 Galactose oxidase%2C central domain NA K10454 NA Energy metabolism 00190 Oxidative phosphorylation NA LFTS_01648 2772.52770928872 0.581436176664807 0.168625197238651 3.44809782989854 0.000564549515742364 0.00328681521343213 540 large subunit ribosomal protein L6 NA K02933 Translation Translation 03010 Ribosome COG0097 J LFTS_00255 798.703905424536 -0.494540977644529 0.14358455878254 -3.44424903233164 0.00057264799064098 0.00332617501105952 1431 methylenetetrahydrofolate--tRNA-(uracil-5-)- methyltransferase NA K04094 NA Cellular community - prokaryotes 02024 Quorum sensing COG1206 J LFTS_02134 640.064420745046 0.602210993358368 0.175491185427106 3.43157402403273 0.000600089332822686 0.00347744074917762 297 hypothetical protein NA NA NA NA NA NA NA LFTS_00849 4902.93288314674 0.431509507454257 0.126107573644911 3.42175727422434 0.000622178303382315 0.00359705874932194 1299 carboxyl-terminal processing protease NA K03797 NA Glycan biosynthesis and metabolism 00550 Peptidoglycan biosynthesis COG0793 O LFTS_00276 171.583655060834 0.742495003216398 0.217833903119973 3.40853738826626 0.000653121344581871 0.00376719179264624 660 hypothetical protein NA NA NA NA NA NA NA LFTS_00897 776.384954805613 0.45771690501493 0.134427492747602 3.40493522314165 0.000661797500988082 0.00380839950800086 447 biopolymer transport protein TolR NA K03560 NA Membrane transport 02010 ABC transporters COG0848 U LFTS_00442 605.052109798251 0.774980318174863 0.228104737813533 3.39747576312237 0.000680106122196165 0.00390472013805927 1275 sulfide:quinone oxidoreductase NA K03885 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG1252 C LFTS_01638 3848.16712521019 0.568823227074613 0.167458491618497 3.39680133014993 0.000681784463508509 0.00390533681171003 975 DNA-directed RNA polymerase subunit alpha NA K03040 Nucleotide metabolism; Transcription Nucleotide metabolism 00230 Purine metabolism COG0202 K LFTS_02498 1025.61966781801 0.660469185848822 0.195242000880753 3.38282328018249 0.000717447823760952 0.00410017308016029 855 chromosome partitioning protein%2C ParB family NA K03497 NA Folding, sorting and degradation 04122 Sulfur relay system COG1475 D LFTS_01647 1236.32751134947 0.647491068683171 0.19146499384397 3.38177259290974 0.000720197379189569 0.00410273028952492 354 large subunit ribosomal protein L18 NA K02881 Translation Translation 03010 Ribosome COG0256 J LFTS_02122 2815.98496019027 0.531776896385175 0.157265678536865 3.38139193072898 0.000721195951939819 0.00410273028952492 1017 cytochrome c peroxidase Oxidative stress response K00428 NA Cell growth and death 04214 Apoptosis - fly COG1858 O LFTS_01985 4266.94183517524 -0.384558907554058 0.113856658193864 -3.3775706546671 0.000731291633632491 0.00415066438632505 1728 proteasome-associated ATPase NA K13527 Folding, sorting and degradation Folding, sorting and degradation 03050 Proteasome COG0464 MDT LFTS_02275 3074.3883693629 0.392627249806862 0.116279960459282 3.37656848399386 0.000733960978954064 0.0041563257259221 1251 hypothetical protein NA K03628 Folding, sorting and degradation Folding, sorting and degradation 03018 RNA degradation COG1158 K LFTS_01923 1184.6557812862 -0.51303426502722 0.152152080667241 -3.37185178656369 0.000746646171758402 0.00421855087043497 573 Diadenosine tetraphosphate (Ap4A) hydrolase NA K02503 NA Nucleotide metabolism 00240 Pyrimidine metabolism COG0537 FGR LFTS_00417 2596.29193719056 -0.49454076137164 0.147169232300683 -3.36035429172613 0.000778425790461957 0.00438813268727534 1812 molecular chaperone HscA NA K04044 NA Amino acid metabolism 00310 Lysine degradation COG0443 O LFTS_01746 268.705506233813 -0.582479162282625 0.173830464874742 -3.35084625530022 0.000805650183002362 0.00453132659489564 1452 hypothetical protein NA K05844 NA Folding, sorting and degradation 04122 Sulfur relay system COG0189 HJ LFTS_01545 754.22780463829 0.591973299606505 0.17696450716759 3.34515270367686 0.000822372793046017 0.004608216390086 546 cation transport protein ChaC NA K07232 NA Replication and repair 03410 Base excision repair COG3703 P LFTS_00648 1687.21097690152 0.456866727509424 0.136584767920033 3.34493175532507 0.000823028188736196 0.004608216390086 813 adenylyltransferase and sulfurtransferase NA K11996 Folding, sorting and degradation Folding, sorting and degradation 04122 Sulfur relay system COG0476;COG0607 HP LFTS_00109 1080.49705632583 0.50996943175172 0.152718387508602 3.33927983441414 0.000839959038061366 0.00469244532274282 1407 hypothetical protein NA K02498 NA Carbohydrate metabolism 00500 Starch and sucrose metabolism COG3071 S LFTS_01485 1406.24777679841 0.422087626320949 0.126468839808935 3.33748318525436 0.000845408370377123 0.00471229867434423 795 Putative negative regulator of RcsB-dependent stress response NA K05807 NA Energy metabolism 00190 Oxidative phosphorylation COG4105 M LFTS_02121 1495.97285366807 0.566055569917433 0.170097089081719 3.32783807749636 0.000875227212437529 0.00486759474299709 603 peroxiredoxin (alkyl hydroperoxide reductase subunit C) Oxidative stress response K03386 Cell growth and death Cell growth and death 04214 Apoptosis - fly COG0450 V LFTS_00239 128.319542297858 1.42470764215418 0.428402355158687 3.32562980804912 0.000882190110403254 0.00489536744299663 1077 hypothetical protein NA NA NA NA NA NA NA LFTS_00360 2192.83069259713 0.406902043613606 0.122438240886345 3.32332480986327 0.000889512753577338 0.00492500825254624 2199 ribonucleoside-diphosphate reductase class II NA K00525 Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0209 F LFTS_00390 453.696992195244 -0.752949588805195 0.226774402534205 -3.320258284846 0.000899342010320131 0.00496836497256855 306 hypothetical protein NA NA NA NA NA NA NA LFTS_00850 7318.43827704083 -0.555041050204456 0.167473294384437 -3.31420631715976 0.000919036671255963 0.00506590945619141 264 chaperonin GroES NA K04078 NA Immune system 04621 NOD-like receptor signaling pathway COG0234 O LFTS_01388 1115.39806532794 -0.466642832683541 0.140832560258714 -3.31345842059749 0.000921498073186665 0.00506823940252666 333 cytochrome c Cytochrome c K12263 NA Energy metabolism 00920 Sulfur metabolism COG2010 C LFTS_01000 103.060457742431 0.783063274935357 0.236395910178951 3.31250770938711 0.000924635776098916 0.00507427050636182 333 hypothetical protein NA NA NA NA NA NA NA LFTS_00881 1259.81488035259 0.497225095995574 0.150407969385183 3.30584275572672 0.000946912112896468 0.00518507381643308 531 putative sigma-54 modulation protein NA K05808 NA Nucleotide metabolism 00230 Purine metabolism COG1544 J LFTS_00838 5917.97928735747 0.529591136333248 0.160801587474752 3.29344470194613 0.000989678069965079 0.00540343316493463 1776 SSU ribosomal protein S1P NA K02945 Translation Translation 03010 Ribosome COG0539 J LFTS_00730 493.051801293616 -0.634525838857634 0.192687496653176 -3.29303068376946 0.000991136574099031 0.00540343316493463 810 Cytochrome c Cytochrome c K03889 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG2010 C LFTS_01910 116.889587715165 -0.825955554713362 0.25149294931471 -3.28420958505596 0.00102268838504486 0.00556324578823088 900 hypothetical protein NA NA NA NA NA NA NA LFTS_01276 969.0618380516 0.834205170068665 0.254400603704741 3.27910059143118 0.00104138508311573 0.00565258366075484 1101 hypothetical protein NA NA NA NA NA NA NA LFTS_01334 534.844394600587 -0.502370570706148 0.153311800655579 -3.27678997023029 0.001049944395591 0.00568662694431203 615 translation factor SUA5 NA K07566 NA Membrane transport 02010 ABC transporters COG0009 J LFTS_00116 3571.85719674068 -0.537969143455869 0.164469270240778 -3.27094017422403 0.0010719058384222 0.00579295198764696 933 branched-chain amino acid aminotransferase NA K00826 Metabolism of cofactors and vitamins; Amino acid metabolism; Overview Overview 01210 2-Oxocarboxylic acid metabolism COG0115 EH LFTS_00069 743.131407907801 0.596413512955365 0.183196879950344 3.25558772134669 0.00113157934488283 0.00610218275787141 432 F-type H+-transporting ATPase subunit epsilon ATP synthase K02114 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG0355 C LFTS_01386 138.837382986165 -0.737328910143119 0.226577383212124 -3.25420348531796 0.00113710797674288 0.00611872387485456 906 HlyD family secretion protein NA K01993 NA Membrane transport 03070 Bacterial secretion system COG0845 MV LFTS_00879 869.234406112263 0.422486420133439 0.1300634448967 3.24831024173617 0.00116092614636075 0.00622211993390633 747 lipopolysaccharide export system ATP-binding protein NA K06861 Membrane transport Membrane transport 02010 ABC transporters COG1137 M LFTS_02391 570.503395982813 0.558985501330061 0.17209023861338 3.24821155362498 0.00116132890158187 0.00622211993390633 1215 glutamate N-acetyltransferase NA K00620 Overview; Amino acid metabolism Overview 01210 2-Oxocarboxylic acid metabolism COG1364 E LFTS_00274 63104.6526877278 0.485787908714367 0.149659349799994 3.2459576322066 0.00117056258760738 0.00625810450062787 1617 cytochrome NA NA NA NA NA NA NA LFTS_00857 4348.46032565523 0.379973632347226 0.117194848507693 3.24223835079479 0.00118594791067421 0.0063267521586611 465 S-adenosylmethionine decarboxylase Spermidine K01611 Amino acid metabolism Amino acid metabolism 00270 Cysteine and methionine metabolism COG1586 E LFTS_00018 90.4593390786974 -0.866694806023601 0.267450796741994 -3.24057664655114 0.00119288198427997 0.00635011694415416 969 Permease of the drug/metabolite transporter (DMT) superfamily protein NA K03298 NA Metabolism of cofactors and vitamins 00130 Ubiquinone and other terpenoid-quinone biosynthesis COG0697 GER LFTS_00834 457.981242787601 0.520418468670173 0.160727151573831 3.23790015298763 0.00120412943635193 0.00638779193792049 441 Fur family transcriptional regulator%2C ferric uptake regulator NA K03711 NA Immune system 04621 NOD-like receptor signaling pathway COG0735 P LFTS_00533 140.782123700216 -0.784729993826777 0.242374865305543 -3.23767067528858 0.00120509831813544 0.00638779193792049 2046 hypothetical protein NA NA NA NA NA NA NA LFTS_02143 6912.33305916763 0.450098595046778 0.139330519522608 3.23043792981584 0.00123600738681849 0.00652546576355387 2400 phosphoenolpyruvate synthase Reductive TCA cycle carbon dioxide fixation K01007 Energy metabolism; Overview; Carbohydrate metabolism Overview 01200 Carbon metabolism COG0574 G LFTS_02096 376.747636970319 -0.519161857349423 0.160713045722936 -3.23036536961934 0.00123632114828394 0.00652546576355387 342 Septum formation initiator NA K05589 NA Overview 01210 2-Oxocarboxylic acid metabolism COG2919 D LFTS_01027 469.024248663175 -0.574546560679855 0.178030303064499 -3.22724025511377 0.00124990463557752 0.00657105704495701 1593 hypothetical protein NA K10300 NA Metabolism of other amino acids 00410 beta-Alanine metabolism NA LFTS_01473 351.327483931747 -0.568903887978138 0.176286111681324 -3.22716226793042 0.00125024536696085 0.00657105704495701 1170 oxygen-independent coproporphyrinogen-3 oxidase NA K02495 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0635 H LFTS_00753 289.848296099529 0.671637506323503 0.208256577866953 3.2250482227389 0.00125951451449491 0.00660580819205557 1320 arsenite efflux membrane protein ArsB (TC 3.A.4.1.1%3B TC 2.A.45.1.1) Arsenic resistance K03893 NA Energy metabolism 00190 Oxidative phosphorylation COG1055 P LFTS_00618 678.733927102006 0.440215024814937 0.136634935582551 3.2218335884454 0.00127373091033173 0.00666232358747766 1341 Surface antigen NA K07277 NA Overview 01230 Biosynthesis of amino acids COG4775 M LFTS_00098 423.36845993142 -0.546011857063202 0.16949509199685 -3.2214021694112 0.00127565005134327 0.00666232358747766 387 6-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase NA K01737 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG0720 H LFTS_02393 4128.69379782073 0.456348255503095 0.14193491649796 3.21519374346238 0.00130356508766015 0.00679384236461871 408 SSU ribosomal protein S9P NA K02996 Translation Translation 03010 Ribosome COG0103 J LFTS_00551 67.7859332769438 -0.88246179187813 0.274779996188503 -3.21152123196315 0.00132034213555222 0.00686688399368792 1344 sugar transferase%2C PEP-CTERM system associated/exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase Extracellular polysaccharide production and export K03606 Cellular community - prokaryotes Cellular community - prokaryotes 05111 Biofilm formation - Vibrio cholerae COG2148 M LFTS_00933 787.106061447033 -0.64169485643905 0.199862730624351 -3.21067792096335 0.00132422263740405 0.0068726878425605 966 protein translocase subunit secF NA K12257 Cellular community - prokaryotes; Folding, sorting and degradation; Membrane transport Folding, sorting and degradation 03060 Protein export COG0342;COG0341 U LFTS_00941 1009.96919923499 -0.687006907256731 0.214492831759483 -3.20293644137764 0.00136034000295905 0.00704542759865874 954 membrane fusion protein%2C multidrug efflux system NA K03543 NA Folding, sorting and degradation 03018 RNA degradation COG1566 V LFTS_00055 648.785187497147 0.442326406049408 0.138142527132034 3.20195681396968 0.00136497459936221 0.00705473358422965 306 preprotein translocase subunit SecG NA K03075 Cellular community - prokaryotes; Folding, sorting and degradation; Membrane transport Folding, sorting and degradation 03060 Protein export COG1314 U LFTS_00653 894.992169265409 0.496663093671947 0.155301977627281 3.19804745090832 0.00138361511454335 0.00713623895177337 429 Proteasome lid subunit RPN8/RPN11%2C contains Jab1/MPN metalloenzyme (JAMM) motif NA K11865 NA Folding, sorting and degradation 04122 Sulfur relay system NA LFTS_01740 106.386183097071 -0.893728698056123 0.279552343841456 -3.19699948058024 0.00138865176598126 0.00714738776445013 522 Tetratricopeptide repeat-containing protein NA K12284 NA Folding, sorting and degradation 04122 Sulfur relay system NA LFTS_00965 10482.2959682782 0.55628804513915 0.174104232538075 3.19514371953878 0.00139761224143062 0.00717864469462089 1011 isocitrate dehydrogenase (NAD+) Reductive TCA cycle carbon dioxide fixation; Oxidative stress response K00030 Carbohydrate metabolism; Overview Overview 01200 Carbon metabolism COG0473 CE LFTS_00167 1072.06605596652 -0.513587484168042 0.161012023273806 -3.18974616755589 0.00142397805524109 0.00729898854707084 3111 cobalt-zinc-cadmium resistance protein CzcA Cadmium/cobalt/zinc resistance K15726 NA Signal transduction 02020 Two-component system COG3696 P LFTS_02007 971.729900612846 0.482476011830463 0.151308722676108 3.18868604068023 0.00142921010576802 0.00731073317477221 645 hypothetical protein NA NA NA NA NA NA NA LFTS_01929 702.037896672885 0.633324219887423 0.198807883152043 3.18560919137735 0.00144449582020603 0.00737375073723244 663 hypothetical protein NA K07286 NA Nucleotide metabolism 00240 Pyrimidine metabolism COG3056 S LFTS_01502 449.3096534397 0.487188838910691 0.153162393186884 3.18086462853998 0.00146836225755038 0.00748022248416034 786 phospholipid/cholesterol/gamma-HCH transport system permease protein NA K02066 Membrane transport Membrane transport 02010 ABC transporters COG0767 M LFTS_00796 1261.0271425255 0.500309712637289 0.157616977424769 3.17421207291003 0.00150243871681582 0.00763816492843382 828 Polyphosphate:AMP phosphotransferase NA K00947 NA Carbohydrate metabolism 00650 Butanoate metabolism NA LFTS_01889 1219.8169560678 0.464119697054458 0.146303289401139 3.1723121124223 0.00151230380645624 0.00766073725199209 2442 ATP-dependent Lon protease NA K01338 Cell growth and death Cell growth and death 04112 Cell cycle - Caulobacter COG0466 O LFTS_01154 47.8115554128099 -1.00160170313253 0.31574649736507 -3.17217043258111 0.00151304183054228 0.00766073725199209 273 Thioredoxin domain-containing protein NA K03676 NA Signal transduction 02020 Two-component system COG0695 O LFTS_02074 532.816503755013 -0.479122791225331 0.151396152174099 -3.16469596053115 0.00155245082180059 0.00784429419308187 1230 hypothetical protein NA NA NA NA NA NA NA LFTS_01264 166.954660640139 -0.747085093705856 0.236577893593795 -3.15788209268869 0.00158919820780893 0.00801368508035094 492 hypothetical protein NA NA NA NA NA NA NA LFTS_00495 926.151811944939 0.760141474604992 0.241333574975936 3.14975433766639 0.00163407804506151 0.00822331583000588 1374 glutamate decarboxylase Proton consuming reactions K01580 Metabolism of other amino acids; Cellular community - prokaryotes; Amino acid metabolism; Carbohydrate metabolism; Nervous system; Endocrine and metabolic diseases Carbohydrate metabolism 00650 Butanoate metabolism COG0076 E LFTS_01528 2648.96949673815 0.372339894551278 0.118275870429255 3.14806302587296 0.00164356252225803 0.00824367655660769 1332 UDPglucose 6-dehydrogenase Extracellular polysaccharide production and export K00012 Carbohydrate metabolism Carbohydrate metabolism 00040 Pentose and glucuronate interconversions COG1004 M LFTS_01840 310.892305402427 -0.709407755449843 0.225362571105645 -3.14785082531423 0.00164475606278255 0.00824367655660769 1398 membrane-bound serine protease (ClpP class) NA K07403 NA Nucleotide metabolism 00230 Purine metabolism COG1030 O LFTS_02145 239.139943865623 0.556671664129165 0.17733851327777 3.13903423368186 0.00169505644027778 0.0084786927777275 624 hypothetical protein NA K08173 NA Signal transduction 02020 Two-component system COG0477 GEPR LFTS_00108 1915.75177848967 0.503875772922604 0.161234191262397 3.12511737726015 0.00177734123958896 0.00887243036469508 558 ribosome-associated protein NA K09710 NA Carbohydrate metabolism 00500 Starch and sucrose metabolism COG0799 J LFTS_01933 813.740144432419 0.529204508628768 0.170193653488674 3.10942563239577 0.00187451466883553 0.00932513934707895 1296 glycerate 2-kinase NA K00050 Carbohydrate metabolism; Amino acid metabolism Carbohydrate metabolism 00630 Glyoxylate and dicarboxylate metabolism COG2379 G LFTS_01091 69.2148306510648 0.860821942970801 0.276857005710345 3.10926552413637 0.00187553084213173 0.00932513934707895 285 Homeodomain-like domain-containing protein NA K11686 NA Amino acid metabolism 00310 Lysine degradation COG0789 K LFTS_01228 233.528594824177 0.569543859390298 0.183418714913037 3.10515674292196 0.00190178215345911 0.00943678729241389 711 Methyltransferase domain-containing protein NA K00588 Biosynthesis of other secondary metabolites; Amino acid metabolism Amino acid metabolism 00360 Phenylalanine metabolism COG4122 R LFTS_02366 1720.49991145668 -0.445980097403188 0.143838922790858 -3.10055226186339 0.00193160123440756 0.00956565870266376 741 demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1%2C4-benzoquinol methylase NA K03183 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00130 Ubiquinone and other terpenoid-quinone biosynthesis COG2226 H LFTS_02361 4691.21319023157 -0.672164102757513 0.216917887580145 -3.09870297122992 0.00194369780023552 0.00960642690136283 189 hypothetical protein NA NA NA NA NA NA NA LFTS_01201 111.300772105103 -0.795588964136992 0.256940929921921 -3.09638859164538 0.00195893458514508 0.00966115003075962 3219 nitrite reductase (NADH) large subunit Nitrite uptake & assimilation to ammonia K00362 Energy metabolism Energy metabolism 00910 Nitrogen metabolism COG1251 C LFTS_01639 2562.89146403088 0.489898739212815 0.158244052343569 3.09584298403316 0.00196254254446243 0.00966115003075962 630 SSU ribosomal protein S4P NA K02986 Translation Translation 03010 Ribosome COG0522 J LFTS_01380 52.8349088986159 -1.00757160652331 0.325649673042068 -3.09403536969972 0.00197453945028099 0.00970099816877181 654 protein TonB NA K03832 NA Membrane transport 03070 Bacterial secretion system COG0810 M LFTS_02447 1741.05842155408 0.47416404482609 0.153330357041354 3.09243423139102 0.00198522218536919 0.0097342452718497 402 putative hydrolase of the HAD superfamily protein NA NA NA NA NA NA NA LFTS_01803 378.61961799438 0.586125543975341 0.189573666614078 3.09180887010292 0.00198940895928232 0.00973557219050364 312 DNA replication protein DnaC NA K02315 NA Overview 01200 Carbon metabolism COG1484 L LFTS_00237 230.224731947986 0.78049690362912 0.252665938382781 3.08904678099781 0.00200799818011364 0.00980723669108547 459 hypothetical protein NA NA NA NA NA NA NA LFTS_01861 564.748285630264 -0.55765219264022 0.180771609230782 -3.08484388125512 0.00203659024326937 0.00992737910738756 1140 23S rRNA (adenine2503-C2)-methyltransferase NA K06941 NA Carbohydrate metabolism 00500 Starch and sucrose metabolism COG0820 J LFTS_00256 455.506514854839 -0.587190750116702 0.190510267929713 -3.08220001209247 0.00205476722480226 0.00999638223259963 966 integrase/recombinase XerC NA K03733 NA Amino acid metabolism 00330 Arginine and proline metabolism COG0582 LX LFTS_00682 1258.84231158686 0.421926434443303 0.137016668336147 3.07938033793216 0.0020743168090543 0.0100717804439629 756 23S rRNA (cytidine1920-2'-O)/16S rRNA (cytidine1409-2'-O)-methyltransferase NA K06442 NA Carbohydrate metabolism 00052 Galactose metabolism COG1189 J LFTS_01592 687.980700664812 0.430298381549992 0.139908258641305 3.07557527860586 0.00210096885155131 0.0101556092297207 474 acetyl-CoA carboxylase biotin carboxyl carrier protein NA K02160 Carbohydrate metabolism; Overview; Energy metabolism; Lipid metabolism Overview 01200 Carbon metabolism COG0511 HI LFTS_02510 596.647651747831 -0.435629137173838 0.141658472501173 -3.07520707714981 0.00210356446651807 0.0101556092297207 672 precorrin-6Y C5%2C15-methyltransferase (decarboxylating) NA K00595 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG2241;COG2242 H LFTS_01299 518.121614580733 0.446680388930181 0.145253958362688 3.07516844267235 0.00210383698845784 0.0101556092297207 1803 ATP-binding cassette%2C subfamily B%2C MsbA Lipopolysaccharide synthesis K11085 Membrane transport Membrane transport 02010 ABC transporters COG1132 V LFTS_00735 187.031353571402 -0.734451997664914 0.238936898186672 -3.07383247727237 0.00211328063500458 0.0101814256950027 1491 C-3'%2C4' desaturase CrtD NA K09835 Metabolism of terpenoids and polyketides Metabolism of terpenoids and polyketides 00906 Carotenoid biosynthesis COG1233 Q LFTS_01002 59.8885229865169 0.856896173012728 0.279029764564427 3.07098482611834 0.002133539932311 0.0102591494617507 96 Site-specific recombinase XerD NA K03733 NA Energy metabolism 00190 Oxidative phosphorylation COG0582 LX LFTS_00077 813.742178292502 -0.789962160429869 0.258430545992809 -3.05676775705861 0.00223737553300103 0.0107376748552906 1491 Outer membrane protein assembly factor BamB%2C contains PQQ-like beta-propeller repeat NA K00114 Carbohydrate metabolism; Xenobiotics biodegradation and metabolism Carbohydrate metabolism 00010 Glycolysis / Gluconeogenesis COG4993 G LFTS_00445 994.641116644003 0.622727364996567 0.204125732596156 3.05070486252008 0.00228304871439382 0.0109357593525685 312 hypothetical protein NA K01999 Cellular community - prokaryotes; Membrane transport Membrane transport 02010 ABC transporters COG0683 E LFTS_00946 626.308311331348 -0.517805408151588 0.170285790908969 -3.04080220309396 0.00235948777288901 0.011279568574138 1059 heat-inducible transcription repressor HrcA NA K03705 NA Folding, sorting and degradation 03018 RNA degradation COG1420 K LFTS_01670 1956.75651619286 0.593240970686563 0.195147457814474 3.03996258690981 0.00236607538675822 0.011279568574138 555 transcription antitermination protein nusG NA K02601 NA Folding, sorting and degradation 03060 Protein export COG0250 K LFTS_00547 83.3359047232515 -0.773010702269361 0.254308103759632 -3.03966209035949 0.00236843716641192 0.011279568574138 1146 Glycosyltransferase%2C catalytic subunit of cellulose synthase and poly-beta-1%2C6-N-acetylglucosamine synthase Extracellular polysaccharide production and export K11936 Cellular community - prokaryotes Cellular community - prokaryotes 02026 Biofilm formation - Escherichia coli COG1215 N LFTS_01649 2113.71854073786 0.711239150165594 0.234095853103003 3.03823899799134 0.00237965143158622 0.0113113068048247 399 small subunit ribosomal protein S8 NA K02994 Translation Translation 03010 Ribosome COG0096 J LFTS_00675 37873.3269209174 -1.26506143313112 0.416739619809857 -3.0356159409761 0.00240044913345589 0.0113883903545255 1383 Recombination protein MgsA NA K07478 NA Energy metabolism 00190 Oxidative phosphorylation COG2256 L LFTS_01335 20032.2428024271 0.51153318005478 0.168617333494203 3.03369273759964 0.00241580340839616 0.0114264889892539 384 Putative peptidoglycan binding domain-containing protein NA K13582 Cell growth and death Cell growth and death 04112 Cell cycle - Caulobacter COG0790;COG3409 TM LFTS_01821 278.567704146082 -0.88964836355712 0.293278478595115 -3.0334594199301 0.00241767224792741 0.0114264889892539 1662 NAD(P)H-quinone oxidoreductase subunit 5 NADH dehydrogenase K05577 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG1009 CP LFTS_01537 504.987841753046 0.443447290137801 0.146356084965993 3.02992041800544 0.00244618185337513 0.0115392942836633 666 cytidylate kinase NA K00945 Nucleotide metabolism Nucleotide metabolism 00240 Pyrimidine metabolism COG0283 F LFTS_00190 1321.26954143112 -0.443687247289329 0.146549515469898 -3.02755860957087 0.00246537900502043 0.0116078261486379 1491 glycine dehydrogenase (decarboxylating) beta subunit NA K00283 Carbohydrate metabolism; Overview; Amino acid metabolism Overview 01200 Carbon metabolism COG1003 E LFTS_02516 761.181491756904 -0.417607703948947 0.138183706745996 -3.02211971138231 0.00251011258722996 0.011796105655678 756 orotidine-5'-phosphate decarboxylase NA K01591 Nucleotide metabolism Nucleotide metabolism 00240 Pyrimidine metabolism COG0284 F LFTS_00240 67.5112229427135 1.19015135378473 0.393958505182198 3.02100687795611 0.00251935637166864 0.0118172074339023 714 hypothetical protein NA NA NA NA NA NA NA LFTS_00928 1303.94526122671 -0.593566142824531 0.196861146779525 -3.01515130097914 0.00256851091853734 0.0120250812494988 1038 N6-L-threonylcarbamoyladenine synthase NA K01409 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0533 J LFTS_01907 9056.41969223747 -0.467337650432526 0.155082160849103 -3.01348425811046 0.00258266439590293 0.0120686159552908 1413 glutamine synthetase Ammonia & glutamate conversion to glutamine K01915 Carbohydrate metabolism; Amino acid metabolism; Energy metabolism; Overview; Signal transduction; Nervous system Overview 01230 Biosynthesis of amino acids COG0174 E LFTS_00361 3242.27927707309 0.45026348274565 0.149685095232814 3.00807159220048 0.00262911194314973 0.0122626121776177 420 Rubrerythrin Oxidative stress response K02217 NA Nucleotide metabolism 00230 Purine metabolism COG1528 P LFTS_02063 123.595290247712 -0.68736153639753 0.228715170647887 -3.00531676342424 0.00265304395138857 0.0123367196170192 435 hypothetical protein NA NA NA NA NA NA NA LFTS_00696 1442.87651085442 0.390743163350577 0.130045148760825 3.00467312371044 0.00265866405780738 0.0123367196170192 510 NADH-quinone oxidoreductase subunit J NADH dehydrogenase K00339 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG0839 C LFTS_02441 370.248376337447 -0.565746812115319 0.188297745872714 -3.00453311054373 0.00265988805901942 0.0123367196170192 327 MerR family transcriptional regulator%2C heat shock protein HspR NA K13640 NA Amino acid metabolism 00250 Alanine, aspartate and glutamate metabolism COG0789 K LFTS_00729 733.652207884443 -0.497156262679579 0.165561718144951 -3.0028455143496 0.0026746816682905 0.0123822320807638 609 hypothetical protein NA NA NA NA NA NA NA LFTS_00174 1230.61691231331 -0.433998246405332 0.14489109396218 -2.99534108368742 0.00274138106970405 0.0126674225637254 1311 GGDEF domain-containing protein%2C diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants Putative diguanylate cyclases (GGDEF domain-containing proteins) K13069 NA Cancers 05206 MicroRNAs in cancer COG2199 T LFTS_00503 2423.11254391864 -0.354747205717434 0.118474201986725 -2.99429917879661 0.00275076070743733 0.0126871820383844 1143 two-component system%2C cell cycle response regulator Putative diguanylate cyclases (GGDEF domain-containing proteins) K13590 Cell growth and death Cell growth and death 04112 Cell cycle - Caulobacter COG2199 T LFTS_01976 209.742777777851 0.568085943801909 0.189769962940724 2.99355037540559 0.00275751982606947 0.0126948042363124 720 putative Fe2+/Mn2+ transporter%2C VIT1/CCC1 family NA K03968 Neurodegenerative diseases; Endocrine and metabolic diseases; Energy metabolism Energy metabolism 00190 Oxidative phosphorylation NA LFTS_01294 910.385541931455 0.44856241296606 0.149930170244101 2.99180886832688 0.00277329835595159 0.0127438442012859 864 acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase Lipopolysaccharide synthesis K00677 Glycan biosynthesis and metabolism; Drug resistance Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG1043 M LFTS_02529 513.928682386534 0.501426506407859 0.168213110576608 2.98090026805311 0.00287402374335373 0.0131823303062313 1056 hypothetical protein NA NA NA NA NA NA NA LFTS_01582 3483.74963214021 0.44420099548673 0.149212257207231 2.97697390147921 0.00291108789979896 0.0133277431287297 1407 Penicillin binding protein transpeptidase domain-containing protein NA K05364 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00550 Peptidoglycan biosynthesis COG0768 DM LFTS_02149 418.0426133964 0.674354238683268 0.226716836802432 2.97443387175926 0.00293529715506844 0.0134138763373164 744 NADP-dependent 3-hydroxy acid dehydrogenase YdfG NA K16066 Nucleotide metabolism; Amino acid metabolism Nucleotide metabolism 00240 Pyrimidine metabolism COG4221 C LFTS_02323 1626.02630477857 -0.502006747303238 0.168949461455818 -2.97134269016015 0.0029650072859216 0.0135247855280754 651 hypothetical protein NA NA NA NA NA NA NA LFTS_01139 519.241308769197 0.444126343685919 0.149729578968151 2.96618975854056 0.00301514391813294 0.013728292638239 738 CRISPR-associated protein%2C Cas5e family NA NA NA NA NA NA NA LFTS_00764 427.174592496676 -0.509080437114117 0.171723725910628 -2.9645317466444 0.00303143962766371 0.0137772557849579 231 SAP domain-containing protein NA NA NA NA NA NA NA LFTS_01991 6869.45963202041 0.436004351016024 0.147174641248832 2.96249644175358 0.00305155336452384 0.0138433607011063 1359 glutamyl-tRNA reductase NA K02492 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0373 H LFTS_02477 1710.58656713957 -0.550883274090872 0.186078291481341 -2.96049189674612 0.00307148201614334 0.0138917877551566 540 signal peptidase II NA K03101 Folding, sorting and degradation Folding, sorting and degradation 03060 Protein export COG0597 MU LFTS_02303 498.4366601579 0.604450802905744 0.204185715615319 2.96029916237879 0.00307340437060988 0.0138917877551566 378 SmpA / OmlA family protein NA K06186 NA Lipid metabolism 00564 Glycerophospholipid metabolism COG2913 M LFTS_00574 237.487947658923 0.600755886231331 0.203049570736044 2.95866612302416 0.00308973657593796 0.0139402633898036 570 protein-tyrosine phosphatase NA K01104 NA Cellular community - prokaryotes 02024 Quorum sensing COG0394;COG5599;COG2365;COG2453;COG4464 T LFTS_01034 395.329089645366 0.524405113093639 0.178092828442901 2.94456052879058 0.00323413679160792 0.0145325837715389 1371 DNA methylase NA K00590 NA Amino acid metabolism 00270 Cysteine and methionine metabolism COG0863 L LFTS_01805 1788.91558933389 0.571207408202584 0.194025297480166 2.94398418979863 0.00324016551275142 0.0145325837715389 1698 hypothetical protein NA NA NA NA NA NA NA LFTS_02140 719.698659589798 -0.508923764798589 0.172880384549836 -2.94379125846913 0.00324218593295825 0.0145325837715389 183 hypothetical protein NA K06575 Immune system; Infectious diseases Immune system 04640 Hematopoietic cell lineage NA LFTS_02104 1047.66215034376 -0.425656347767254 0.144604999485204 -2.94357974677638 0.00324440224988097 0.0145325837715389 2241 DNA helicase-2 / ATP-dependent DNA helicase PcrA NA K03657 Replication and repair Replication and repair 03420 Nucleotide excision repair COG0210 L LFTS_01214 769.073671535275 -0.577370457210083 0.196208486310181 -2.94263753860948 0.00325429192132006 0.014550664957557 1470 two-component system%2C NtrC family%2C response regulator AtoC NA K07714 Signal transduction Signal transduction 02020 Two-component system COG2204 T LFTS_02232 312.033053264951 0.545232071492849 0.185414559820636 2.94061087770177 0.00327565743925044 0.0146199001687192 1263 putative arabinose efflux permease%2C MFS family NA K05820 NA Metabolism of cofactors and vitamins 00770 Pantothenate and CoA biosynthesis COG0477 GEPR LFTS_01135 328.845399286899 0.485914107465248 0.165419777701008 2.93746076931337 0.00330912036592833 0.0147427835657667 1533 CRISPR system Cascade subunit CasA NA NA NA NA NA NA NA LFTS_00872 775.892114506834 -0.475619126589412 0.162187949768321 -2.93251827443909 0.00336225134502292 0.0149347108499384 4350 PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein NA K13069 NA Metabolism of cofactors and vitamins 00770 Pantothenate and CoA biosynthesis COG2199 T LFTS_00260 204.908570644174 -0.641226057849898 0.218674068000629 -2.93233698770378 0.00336421483345354 0.0149347108499384 471 hypothetical protein NA NA NA NA NA NA NA LFTS_01937 409.269489311163 0.49396008812935 0.168523644649657 2.93110257113321 0.00337761239105773 0.0149674588309617 822 ABC-2 type transport system permease protein NA K09686 NA NA NA NA LFTS_00102 2404.82250107682 0.359984797368949 0.123005606067332 2.92657228298925 0.00342719854374347 0.0151463705966925 321 large subunit ribosomal protein L21 NA K02888 Translation Translation 03010 Ribosome COG0261 J LFTS_01287 490.375081439646 -0.532928942546377 0.182116829053947 -2.92630255707182 0.00343017161944403 0.0151463705966925 261 hypothetical protein NA NA NA NA NA NA NA LFTS_00950 808.748007803216 -0.584967578101758 0.199983712605921 -2.92507609984454 0.00344371997375812 0.0151792337850402 864 16S rRNA (uracil1498-N3)-methyltransferase NA K09761 NA Xenobiotics biodegradation and metabolism 00983 Drug metabolism - other enzymes COG1385 J LFTS_02141 324.500881717905 -0.519830692605748 0.17779364767669 -2.92378664479081 0.00345801675914687 0.0152152737402462 693 hypothetical protein NA NA NA NA NA NA NA LFTS_02412 210.978625592899 -0.734442927870681 0.251259209558804 -2.92304878758601 0.00346622200397785 0.0152244309220652 432 hypothetical protein NA NA NA NA NA NA NA LFTS_02467 1870.79260676031 0.459166165934495 0.157177378806934 2.92132474418283 0.00348546312022322 0.0152819423578041 1023 periplasmic chaperone for outer membrane proteins SurA NA K03771 NA Replication and repair 03420 Nucleotide excision repair COG0760 O LFTS_01644 2191.72895212114 0.497088227124827 0.170534151527269 2.91488961403336 0.00355814369889272 0.0155731430201537 1314 protein translocase subunit secY/sec61 alpha NA K03076 Cellular community - prokaryotes; Folding, sorting and degradation; Membrane transport Folding, sorting and degradation 03060 Protein export COG0201 U LFTS_00365 791.867971761042 0.662524008908778 0.227377790941071 2.9137586664323 0.00357105854608686 0.0155943993657622 318 Outer membrane protein OmpA NA NA NA NA NA NA NA LFTS_01370 226.528059934163 -0.539813011396102 0.185288393932952 -2.91336656299928 0.00357554611363011 0.0155943993657622 507 NusB antitermination factor NA K03625 NA Signal transduction 02020 Two-component system COG0781 K LFTS_01025 1277.52354959496 -0.37534607988054 0.129672870579467 -2.89456135430053 0.00379688700307523 0.0165307549731086 579 hypothetical protein NA NA NA NA NA NA NA LFTS_01479 1709.44156032263 0.471017553207317 0.163125072702962 2.88746264079834 0.0038836272305746 0.0168788414251896 849 acyl-[acyl-carrier-protein] desaturase NA K03921 Lipid metabolism; Overview Overview 01212 Fatty acid metabolism NA LFTS_00138 665.508742336722 -0.412931904597933 0.143106597233696 -2.88548475458197 0.00390811389412963 0.0169556215371837 1395 hypothetical protein NA K02668 Signal transduction Signal transduction 02020 Two-component system COG0642 T LFTS_02012 180.367683210731 -0.575101994670472 0.19976919454019 -2.87883222432862 0.00399150618691778 0.0172872550186021 900 RND family efflux transporter%2C MFP subunit NA K15548 NA Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG1566 V LFTS_01662 1817.7618759614 0.450386655222998 0.156550420255429 2.87694312470158 0.00401547962817619 0.0173608388793844 474 small subunit ribosomal protein S7 NA K02992 Translation Translation 03010 Ribosome COG0049 J LFTS_00706 769.45226416384 0.451435710973053 0.156972935726141 2.87588244995711 0.0040289972514628 0.0173890402207231 813 L-proline dehydrogenase NA K00318 Amino acid metabolism Amino acid metabolism 00330 Arginine and proline metabolism COG0506 E LFTS_00161 698.466449806029 0.466160539930486 0.162678714833789 2.86552878418524 0.00416313423410046 0.0179368313795039 249 TusA-related sulfurtransferase NA K04085 Folding, sorting and degradation Folding, sorting and degradation 04122 Sulfur relay system COG0425 O LFTS_00856 2593.71994445604 0.437038256678638 0.152588746282942 2.86415785780327 0.0041811958237823 0.0179834823839495 861 spermidine synthase Spermidine K00797 Amino acid metabolism; Metabolism of other amino acids Amino acid metabolism 00270 Cysteine and methionine metabolism COG0421 E LFTS_01559 186.284579162776 -0.592759920090435 0.20724533926781 -2.86018456282121 0.00423394522175177 0.0181789081541881 1017 adenosylcobinamide-phosphate synthase NA K02227 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG1270 H LFTS_01834 720.441031526487 -0.388894215782866 0.136001980121933 -2.85947465937041 0.00424343319546621 0.0181882326274638 564 hypothetical protein NA K15017 Overview; Energy metabolism Overview 01200 Carbon metabolism COG0136 E LFTS_01943 7250.8874448147 0.427753315520142 0.149650538802035 2.85834798153313 0.00425853102014091 0.0182215285990883 621 cytochrome b6-f complex iron-sulfur subunit Cytochrome b/c1 K02636 Energy metabolism Energy metabolism 00195 Photosynthesis COG0723 C LFTS_02324 1581.26849904717 -0.491975408675325 0.172513903108699 -2.85180150590725 0.00434722372429005 0.0185690690353695 207 hypothetical protein NA NA NA NA NA NA NA LFTS_00831 1041.38092078405 -0.400822782911295 0.140613420992238 -2.8505300566823 0.00436464249885004 0.0186114944290587 501 Thiol-disulfide isomerase or thioredoxin NA K03671 Cardiovascular diseases; Immune system Immune system 04621 NOD-like receptor signaling pathway COG0526 O LFTS_00654 790.498154216886 0.396262441232364 0.139116445000209 2.84842270970746 0.00439365240064692 0.0187031162123429 696 two-component system%2C OmpR family%2C alkaline phosphatase synthesis response regulator PhoP NA K07658 Signal transduction Signal transduction 02020 Two-component system COG0745 TK LFTS_01891 577.846473327081 0.405271540277552 0.142625468391565 2.84150891736191 0.00449005962324345 0.0190808345698858 1113 peptide chain release factor 2 NA K02836 NA Membrane transport 02010 ABC transporters COG1186 J LFTS_00663 2470.02141729518 -0.395169151986565 0.139682614938755 -2.8290503593438 0.00466863520016484 0.0198058483065013 3420 PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein Genes encoding proteins with EAL and GGDEF domains K14051 Cellular community - prokaryotes Cellular community - prokaryotes 02024 Quorum sensing COG2199;COG2200;COG2202 T LFTS_01455 749.047726971317 0.402304326387177 0.142578261757591 2.82163859643042 0.00477789871375511 0.0202348487263973 1455 methyl-accepting chemotaxis protein Chemotaxis K03406 Signal transduction; Cell motility Signal transduction 02020 Two-component system COG0840 NT LFTS_02408 813.316835388042 -0.401388478680927 0.14234743531631 -2.81978019336282 0.00480565553818314 0.02031778855089 696 ribulose-5-phosphate 3-epimerase NA K01783 Carbohydrate metabolism; Energy metabolism; Overview Overview 01200 Carbon metabolism COG0036 G LFTS_00855 987.091642739706 0.372762477623676 0.132339097914461 2.81672221964681 0.00485164669855582 0.0204774086461965 1470 arginine decarboxylase Proton consuming reactions K01582 Amino acid metabolism; Biosynthesis of other secondary metabolites Amino acid metabolism 00310 Lysine degradation COG1982 E LFTS_00572 205.975748241288 -0.639970325768647 0.227487356018441 -2.81321272957592 0.00490491904063112 0.0206671673474728 951 UDP-glucose 4-epimerase Extracellular polysaccharide production and export K01784 Carbohydrate metabolism Carbohydrate metabolism 00052 Galactose metabolism COG1087 M LFTS_02202 719.186407877363 -0.448227565137331 0.159495482168868 -2.81028377131563 0.0049497836422053 0.0208209173172968 1080 putative glycosyl transferase NA K02563 Cell growth and death; Glycan biosynthesis and metabolism; Drug resistance Glycan biosynthesis and metabolism 00550 Peptidoglycan biosynthesis COG0707 M LFTS_02081 514.653482882129 -0.530429352498475 0.189591342695705 -2.79775091497619 0.00514597802391702 0.0216096306882732 1449 competence protein ComEC NA K02238 NA Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG0658;COG2333 R LFTS_02466 441.514803739552 0.41462848973307 0.148307231130306 2.79574021153944 0.00517810052754389 0.0217078548254201 975 peptidyl-prolyl cis-trans isomerase C NA K03771 NA Replication and repair 03420 Nucleotide excision repair COG0760 O LFTS_02105 1978.73095079495 -0.419569881412198 0.15039732571543 -2.78974296528433 0.0052749900836162 0.0220768103499493 1320 TolB protein NA K03641 NA Replication and repair 03420 Nucleotide excision repair COG0823 U LFTS_02177 1146.5810211631 0.366747687515728 0.131625669647059 2.78629304222441 0.00533146502474257 0.0222516673026291 237 hypothetical protein NA K09794 NA Lipid metabolism 00564 Glycerophospholipid metabolism COG2841 S LFTS_00399 913.983184710974 -0.398366920111809 0.142984803456846 -2.78607873340917 0.00533499118945398 0.0222516673026291 1566 GTP-binding protein HflX NA K03665 NA Signal transduction 02020 Two-component system COG2262 J LFTS_00936 3990.3486891077 -0.313157671208957 0.112422014881031 -2.78555469353892 0.00534362243751793 0.0222516673026291 2289 GTP pyrophosphokinase NA K00951 Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0317 TK LFTS_01231 218.43836097603 -0.529576068331814 0.190266188328041 -2.78334302581793 0.00538018900742328 0.0223664713586192 567 putative kinase inhibitor protein NA K06910 NA Amino acid metabolism 00350 Tyrosine metabolism COG1881 R LFTS_00146 19.9521268686787 -1.11713555693269 0.401539882035107 -2.78212851802107 0.0054003650127228 0.022396076015333 138 hypothetical protein NA NA NA NA NA NA NA LFTS_00626 2365.2384312454 -0.36362982220348 0.130716029059864 -2.78183039080042 0.00540532808093315 0.022396076015333 831 sirohydrochlorin cobaltochelatase NA K03795 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG2138 H LFTS_02250 182.720920250554 -0.804212907432249 0.289562008931655 -2.77734261617886 0.00548053746072371 0.0226699103616625 897 23S rRNA synthase NA K06178 NA Replication and repair 03030 DNA replication COG1187 J LFTS_01930 456.774631505112 0.506210289656919 0.182632588492643 2.77174130769827 0.00557573283594192 0.0230253684886239 369 Cytochrome C oxidase%2C cbb3-type%2C subunit III Cytochrome cbb3 oxidase K00406 Energy metabolism; Signal transduction Energy metabolism 00190 Oxidative phosphorylation COG2010 C LFTS_01436 188.953425046548 0.570039734699038 0.20581663117386 2.76964855292722 0.00561168075566529 0.0231353869959932 183 hypothetical protein NA NA NA NA NA NA NA LFTS_00089 907.627524466089 -0.425808411224431 0.153842610095653 -2.76781842793541 0.00564328863868534 0.0232271780724698 3603 diguanylate cyclase (GGDEF) domain-containing protein Genes encoding proteins with EAL and GGDEF domains K14051 Cellular community - prokaryotes Cellular community - prokaryotes 02024 Quorum sensing COG2199;COG2200;COG2202 T LFTS_00247 822.982912189035 0.479456771819377 0.17334711664235 2.76587682048726 0.00567699741726658 0.0233158282012641 324 YtxH-like protein NA K09908 NA Nucleotide metabolism 00230 Purine metabolism COG3105 S LFTS_00901 1596.40107564828 -0.402312671969944 0.145475637329462 -2.76549860413271 0.00568358483104025 0.0233158282012641 1905 DNA mismatch repair protein MutL NA K03572 Replication and repair Replication and repair 03430 Mismatch repair COG0323 L LFTS_01049 309.294112496927 0.551592879697347 0.199705313766998 2.76203406555775 0.00574424847218573 0.0235258677131033 1416 hypothetical protein NA NA NA NA NA NA NA LFTS_02404 787.052001745466 0.545021112166407 0.197404638506883 2.76093366543362 0.00576363816358753 0.0235664547280898 495 hypothetical protein NA K03571 NA Overview 01200 Carbon metabolism COG2891 M LFTS_00932 850.177080102885 0.429306074676969 0.156145380217106 2.74939978422709 0.00597045168280563 0.024371991598448 1575 preprotein translocase subunit SecD NA K12257 Cellular community - prokaryotes; Folding, sorting and degradation; Membrane transport Folding, sorting and degradation 03060 Protein export COG0342;COG0341 U LFTS_01791 112.083816259007 0.64788309243243 0.236455886805494 2.73997446705723 0.00614439574836214 0.0250409308695546 252 IstB-like ATP binding protein NA K02315 NA Signal transduction 02020 Two-component system COG1484 L LFTS_00380 159.671160643573 -0.611418369500368 0.223387303562523 -2.73703276663278 0.00619961176291329 0.0252128373023053 1104 Site-specific recombinase XerD NA K14059 NA Replication and repair 03030 DNA replication COG0582 LX LFTS_01341 1013.56571815978 0.399416731100494 0.145953130130569 2.7366095591316 0.00620759206496855 0.0252128373023053 1524 lysyl-tRNA synthetase%2C class II NA K04567 Translation Translation 00970 Aminoacyl-tRNA biosynthesis COG1190 J LFTS_00272 407.633461909799 -0.494028929583399 0.180580969509299 -2.73577515352724 0.00622335331109781 0.0252128373023053 507 hypothetical protein NA NA NA NA NA NA NA LFTS_00991 233.386089630367 -0.543041630745716 0.198510985047506 -2.73557471197758 0.00622714485262085 0.0252128373023053 705 exodeoxyribonuclease X NA K10857 Replication and repair Replication and repair 03430 Mismatch repair COG0847 L LFTS_00986 1630.99051780436 -0.397876338992698 0.145494142050663 -2.7346553846419 0.00624456145581099 0.025242243543327 1896 DNA adenine methylase NA K06223 Replication and repair Replication and repair 03430 Mismatch repair COG0338 L LFTS_02139 627.603462353452 -0.384243086615111 0.140714038303608 -2.73066633043434 0.00632064292242554 0.0255083089369316 1434 Purine-cytosine permease NA K03457 NA Translation 03010 Ribosome COG1457;COG1953 FFH LFTS_02022 91.4558136684623 -0.688237108546767 0.252836473576818 -2.72206418168407 0.00648755413881609 0.0261394806954567 1368 hypothetical protein NA K07505 NA Glycan biosynthesis and metabolism 00550 Peptidoglycan biosynthesis COG3598 L LFTS_00338 1871.73758025271 -0.388095885555818 0.14280780637829 -2.71760973995898 0.00657553456918665 0.0264367267388536 840 proteasome beta subunit NA K03433 Folding, sorting and degradation Folding, sorting and degradation 03050 Proteasome COG0638 O LFTS_00451 209.281755026228 0.782595351688376 0.288009584283472 2.71725454427277 0.00658259607858021 0.0264367267388536 1449 Putative beta-barrel porin-2%2C OmpL-like. bbp2 NA NA NA NA NA NA NA LFTS_02446 477.474840100786 0.39705644984698 0.146547435051444 2.70940565904547 0.00674038712224086 0.0270267780417593 528 Phosphate-starvation-inducible E NA K13256 NA Aging 04213 Longevity regulating pathway - multiple species COG3223 R LFTS_01799 2965.12403304321 0.473102477783748 0.17465153973318 2.70883656970057 0.00675195899705951 0.0270295814278421 939 hypothetical protein NA K00477 Transport and catabolism Transport and catabolism 04146 Peroxisome NA LFTS_00194 285.457170903003 -0.476859171086552 0.176175046919464 -2.70673503100891 0.00679484660427071 0.0271575380357186 846 HDIG domain-containing protein NA K07181 Cellular community - prokaryotes Cellular community - prokaryotes 05111 Biofilm formation - Vibrio cholerae COG2200;COG3434 T LFTS_00401 1609.60357488362 -0.377379124945434 0.13948170315658 -2.70558156665032 0.00681849009414329 0.027208292735217 726 hypothetical protein NA K02656 NA Cellular community - prokaryotes 02024 Quorum sensing COG3063 NW LFTS_01415 196.193583845801 0.507864113160511 0.188114809347798 2.6997561484994 0.00693903160068028 0.027644923973223 654 hypothetical protein NA NA NA NA NA NA NA LFTS_00093 968.544453196611 0.342756139917331 0.127012068074078 2.6986108100958 0.00696295527879911 0.0276958509169513 357 LSU ribosomal protein L20P NA K02887 Translation Translation 03010 Ribosome COG0292 J LFTS_00263 301.627937365385 -0.460420455472183 0.17065495515054 -2.69796124622359 0.00697655618176054 0.0277056208751705 861 pantoate--beta-alanine ligase NA K01918 Metabolism of cofactors and vitamins; Metabolism of other amino acids Metabolism of other amino acids 00410 beta-Alanine metabolism COG0414 H LFTS_00454 253.369487270781 0.810990827213591 0.301040595485595 2.69395835437217 0.00706089865322922 0.027995843782979 2013 K+-transporting ATPase ATPase B chain Role of potassium in the internal positive membrane potential K01547 Signal transduction Signal transduction 02020 Two-component system COG2216 P LFTS_02123 813.055047158447 0.416813265413856 0.155118103220244 2.68707041125976 0.00720817562055459 0.0285342748291381 468 Fur family transcriptional regulator%2C peroxide stress response regulator Oxidative stress response K09825 NA Cell growth and death 04214 Apoptosis - fly COG0735 P LFTS_02217 80.925050370594 0.737217378159094 0.275089948000932 2.67991391003715 0.00736410968852578 0.0291052093571941 288 hypothetical protein NA NA NA NA NA NA NA LFTS_00252 178.794164780313 -0.577512515837161 0.215879619978332 -2.67515996134849 0.00746936019558825 0.0294743324543371 273 hypothetical protein NA NA NA NA NA NA NA LFTS_00763 697.387804052924 -0.506860523159332 0.189671916245567 -2.6723013780443 0.00753329566771849 0.0296795135181429 510 transcriptional regulator%2C BadM/Rrf2 family NA K13771 Infectious diseases Infectious diseases 05132 Salmonella infection COG1959 K LFTS_00193 369.429709728726 -0.465649831060195 0.174287555449959 -2.67173310141407 0.00754606413950186 0.0296827776120279 864 HDIG domain-containing protein NA K07181 Cellular community - prokaryotes Cellular community - prokaryotes 05111 Biofilm formation - Vibrio cholerae COG2200;COG3434 T LFTS_01426 54.5146832343541 0.779783592358105 0.292039283087004 2.67013253873039 0.0075821311554176 0.0297775324681961 177 Transposase DDE domain group 1 NA NA NA NA NA NA NA LFTS_02118 658.462143387806 0.398128115983649 0.14933217356216 2.66605719642811 0.00767466345730207 0.0300933964587586 651 2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphate phosphatase NA K08966 Amino acid metabolism Amino acid metabolism 00270 Cysteine and methionine metabolism COG4359 E LFTS_00905 902.355988898131 0.37465151987371 0.140698554532334 2.66279579857099 0.00774944254301952 0.0303387624597583 765 Tfp pilus assembly protein PilF NA K02656 NA Carbohydrate metabolism 00030 Pentose phosphate pathway COG3063 NW LFTS_02067 404.569232329405 -0.456811023443137 0.171720435816748 -2.66020186397981 0.00780938310799943 0.0305253559850418 3306 DNA helicase/exodeoxyribonuclease V%2C beta subunit NA K03582 Replication and repair Replication and repair 03440 Homologous recombination COG1074 L LFTS_01193 48.9092546983758 -0.843031224748189 0.317570232776858 -2.6546292370562 0.00793956200414036 0.0309854806001459 489 LTXXQ motif family protein NA K06006 NA Membrane transport 02010 ABC transporters COG3678 O LFTS_00493 2067.00215938928 -0.403842856373697 0.152807480299927 -2.6428212518199 0.00822184276505003 0.0320368356017467 2718 PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein Genes encoding proteins with EAL and GGDEF domains K14051 Cellular community - prokaryotes Cellular community - prokaryotes 02024 Quorum sensing COG2199;COG2200;COG2202 T LFTS_02426 734.580653234827 0.385252988648212 0.146069035032987 2.63747199097475 0.00835265230149699 0.0324956081713952 1005 UDPglucose--hexose-1-phosphate uridylyltransferase Extracellular polysaccharide production and export K00965 Endocrine system; Carbohydrate metabolism Carbohydrate metabolism 00052 Galactose metabolism COG1085 G LFTS_00871 219.078909344419 -0.626327665058908 0.237521411876709 -2.63693138277579 0.00836597523869771 0.0324965850678164 183 hypothetical protein NA NA NA NA NA NA NA LFTS_00312 125.640454008834 -0.792578018600696 0.300639834182756 -2.63630407046757 0.00838145876659648 0.0325059383677985 1308 ammonium transporter (TC 1.A.11) Ammonia & glutamate conversion to glutamine K03320 NA Signal transduction 02020 Two-component system COG0004 P LFTS_00768 695.847220981523 0.367593373536657 0.139559353378445 2.63395727078105 0.00843961081061825 0.0326324872278543 402 nitric oxide dioxygenase NA K05916 Infectious diseases Infectious diseases 05132 Salmonella infection COG1017;COG1018 C LFTS_01190 247.73441776997 -0.62583964654386 0.237606979944051 -2.633927869843 0.00844034162812161 0.0326324872278543 828 molybdate transport system substrate-binding protein NA K02020 Membrane transport Membrane transport 02010 ABC transporters COG0725 P LFTS_02231 353.842102244874 0.428545574017395 0.162741010147122 2.63329798450912 0.00845601225426217 0.0326423081740617 873 Glyoxylase%2C beta-lactamase superfamily II NA K05337 NA Metabolism of cofactors and vitamins 00770 Pantothenate and CoA biosynthesis COG1141 C LFTS_00313 391.886338609146 -0.468997043433046 0.17826550574907 -2.63089060030052 0.00851614448260805 0.0328234654011839 2532 Cu+-exporting ATPase Copper resistance K01533 NA Signal transduction 02020 Two-component system COG2217 P LFTS_02167 2523.58156635732 0.442709172081357 0.168602430667859 2.62575794623909 0.00864562741225268 0.0332709438805885 1134 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase NA K03526 Metabolism of terpenoids and polyketides Metabolism of terpenoids and polyketides 00900 Terpenoid backbone biosynthesis COG0821 I LFTS_02237 1060.81696292101 0.378692622256211 0.144268512435643 2.62491527681858 0.00866705303208476 0.0333018451897414 672 phosphoglycerate mutase NA K01834 Overview; Amino acid metabolism; Endocrine system; Cancers; Carbohydrate metabolism; Energy metabolism Overview 01200 Carbon metabolism COG0588 G LFTS_00873 1733.85441199527 0.430539110703281 0.164055364798164 2.62435252411873 0.00868138793671947 0.0333054481646367 1218 Transposase (or an inactivated derivative) NA K07493 NA Metabolism of cofactors and vitamins 00770 Pantothenate and CoA biosynthesis COG3328 X LFTS_00810 2994.06307200446 -0.47464838172499 0.181081502081928 -2.62118646171955 0.00876243217406616 0.0335645707006602 120 hypothetical protein NA NA NA NA NA NA NA LFTS_00592 722.774104937145 0.399283153522778 0.152373818916529 2.62041836558225 0.00878219536275141 0.0335885194950769 924 16S rRNA (cytosine1402-N4)-methyltransferase NA K03438 NA Overview 01200 Carbon metabolism COG0275 J LFTS_01699 3093.64026188476 0.373570886159092 0.142607895468964 2.61956664412309 0.00880415679882283 0.0336207892501898 1281 ATP-dependent Clp protease ATP-binding subunit ClpX NA K03544 Cell growth and death Cell growth and death 04112 Cell cycle - Caulobacter COG1219 O LFTS_02084 945.779797316413 -0.657531105178361 0.251245022804886 -2.61709106846265 0.00886826776194196 0.0338136712518217 1104 N-ethylmaleimide reductase NA K10680 Xenobiotics biodegradation and metabolism Xenobiotics biodegradation and metabolism 00633 Nitrotoluene degradation COG1902 C LFTS_00455 144.358058753767 -0.806903376439677 0.308776226462362 -2.61323025313295 0.0089690853977191 0.0341342857059759 609 hypothetical protein NA K14953 Infectious diseases Infectious diseases 05152 Tuberculosis NA LFTS_02296 1100.53029230307 -0.373090401703584 0.142792145065613 -2.61282160536316 0.00897981611090436 0.0341342857059759 648 hypothetical protein NA NA NA NA NA NA NA LFTS_01536 780.337289816938 0.401443041695431 0.154030298852889 2.60626022727412 0.00915368875597155 0.034699096828456 1365 3-phosphoshikimate 1-carboxyvinyltransferase NA K00800 Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG0128 E LFTS_02224 827.670300357764 -0.461545874629463 0.17712355960443 -2.60578477341035 0.00916640400413773 0.034699096828456 1170 putative ATPase NA K06926 NA Lipid metabolism 00564 Glycerophospholipid metabolism COG1106 R LFTS_00747 734.368195366379 0.508494517054891 0.195151478167284 2.60564009983573 0.00917027619320016 0.034699096828456 717 FMN phosphatase YigB%2C HAD superfamily NA K07025 NA Overview 01200 Carbon metabolism COG1011 H LFTS_00301 467.061900592765 0.450896572959756 0.173289391082396 2.60198601970598 0.00926856304907807 0.0350177017325351 351 putative protein involved in oxidation of intracellular sulfur NA K06039 NA Folding, sorting and degradation 04122 Sulfur relay system COG1553 P LFTS_01026 436.469180753668 -0.441417733524808 0.169951268796347 -2.59731943545393 0.00939545036034154 0.0354432315566147 249 hypothetical protein NA NA NA NA NA NA NA LFTS_01949 4434.20495079269 0.332395394841487 0.128031666182895 2.59619674375444 0.00942620734294791 0.0355053809917705 915 acetyl-CoA carboxylase carboxyltransferase subunit alpha NA K01963 Carbohydrate metabolism; Overview; Energy metabolism; Lipid metabolism Overview 01200 Carbon metabolism COG0777 I LFTS_01568 3100.20699863442 0.45774608675681 0.176364389855657 2.59545641345991 0.00944653835476146 0.0355281306353056 540 hypothetical protein NA K11550 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism NA LFTS_00250 180.973306610045 0.533133253642312 0.205462518796043 2.59479566767863 0.00946471683222148 0.0355427281645054 768 NitT/TauT family transport system ATP-binding protein NA K02049 NA Signal transduction 02020 Two-component system COG1116 P LFTS_01532 976.037228577919 0.368002523354452 0.141868646792428 2.5939665435231 0.00948757188132592 0.0355748170391798 759 DNA-binding regulatory protein%2C YebC/PmpR family NA K07741 NA Overview 01230 Biosynthesis of amino acids COG3561 X LFTS_02395 11661.6755326074 0.348701521851538 0.134460791719184 2.59333235654143 0.00950508663938554 0.0355868153396272 1503 hypothetical protein NA K04034 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG1032 R LFTS_02381 4423.81042545978 0.341470631969615 0.131830961588382 2.59021574185126 0.00959157996554515 0.0358067418862502 852 cytochrome c-type biogenesis protein CcsB Cytochrome c K02497 NA Nucleotide metabolism 00240 Pyrimidine metabolism COG0755 O LFTS_00341 1262.62480328623 -0.431750064467249 0.166704973407087 -2.5899051218642 0.0096002387331926 0.0358067418862502 693 hypothetical protein NA NA NA NA NA NA NA LFTS_00797 1801.07150410829 0.345017681980401 0.133228878829483 2.5896613783111 0.00960703814888531 0.0358067418862502 978 Protein-disulfide isomerase NA K03981 NA Carbohydrate metabolism 00650 Butanoate metabolism COG1651 O LFTS_00809 6621.49743945853 0.332846284724858 0.128943593529495 2.58133246960208 0.00984197473377586 0.0366274688445611 2142 polyribonucleotide nucleotidyltransferase NA K00962 Nucleotide metabolism; Folding, sorting and degradation Nucleotide metabolism 00230 Purine metabolism COG1185 J LFTS_02106 1095.957739918 -0.394390775622877 0.153104917730016 -2.57595106329859 0.0099964793227536 0.0371468573936703 1818 glucosamine--fructose-6-phosphate aminotransferase (isomerizing) NA K00820 Amino acid metabolism; Carbohydrate metabolism; Endocrine and metabolic diseases Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG0449 M LFTS_00460 407.817864088691 -0.423283576117111 0.164454878552313 -2.57385843365214 0.01005714142761 0.0373164978940873 579 Outer membrane protein beta-barrel domain protein NA NA NA NA NA NA NA LFTS_00488 721.635528969681 0.377762628973622 0.146901263536992 2.57154104653766 0.0101247012534782 0.0375111882505912 1074 dTDP-glucose 4%2C6-dehydratase Extracellular polysaccharide production and export K01710 Biosynthesis of other secondary metabolites; Metabolism of terpenoids and polyketides Metabolism of terpenoids and polyketides 00523 Polyketide sugar unit biosynthesis COG1088 M LFTS_00175 1486.88602942182 -0.319791898656433 0.124414509378465 -2.57037463117454 0.0101588589315114 0.0375817311067521 1485 Thiol-disulfide isomerase or thioredoxin NA K12035 Cancers Cancers 05206 MicroRNAs in cancer NA LFTS_01543 1257.51486174744 -0.363905649766734 0.141890645291575 -2.5646909210888 0.0103267748516796 0.0381461549498891 870 5%2C10-methylenetetrahydrofolate reductase NA K00297 Metabolism of cofactors and vitamins; Overview; Energy metabolism; Drug resistance Overview 01200 Carbon metabolism COG0685 E LFTS_01529 585.557360916434 0.445573362244991 0.173907633348621 2.56212653616981 0.0104033407625597 0.0383719660767411 1128 glycine oxidase NA K03153 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00730 Thiamine metabolism COG0665 E LFTS_02158 3759.28992529946 0.386739069653284 0.15103812552325 2.56053938906804 0.0104509815544263 0.0384338770395383 1209 3-oxoacyl-[acyl-carrier-protein] synthase II NA K09458 Lipid metabolism; Overview; Metabolism of cofactors and vitamins Overview 01212 Fatty acid metabolism COG0304 IQ LFTS_01901 1692.97095881811 0.389737848101914 0.152209404377372 2.56053723944441 0.0104510462102687 0.0384338770395383 1470 IMP dehydrogenase NA K00088 Xenobiotics biodegradation and metabolism; Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0516;COG0517 FT LFTS_02425 1412.92205475915 0.486062201152467 0.190362347426456 2.55335263366749 0.0106691416542516 0.039177970683116 1383 Fructose/tagatose bisphosphate aldolase NA K01624 Carbohydrate metabolism; Overview; Energy metabolism Overview 01200 Carbon metabolism COG0191 G LFTS_01678 2177.60488993916 0.572315346118215 0.224329310536956 2.5512285699462 0.0107343901119048 0.0393435735058758 1140 sulfide:quinone oxidoreductase NA K00386 NA NA NA NA LFTS_01716 3561.57111016605 0.362980697811597 0.142297640673424 2.5508553486466 0.0107458915569146 0.0393435735058758 1029 hopanoid biosynthesis associated radical SAM protein HpnH NA K03639 Metabolism of cofactors and vitamins; Folding, sorting and degradation Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG2896 H LFTS_00083 663.23796438707 -0.409508981602769 0.160751454181579 -2.54746673171742 0.0108508198721753 0.0396693208856293 876 lactoylglutathione lyase NA K08234 NA Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG0346 Q LFTS_00782 1737.28513135019 0.375691919325475 0.147755756306619 2.54265504584368 0.0110013780032516 0.0401290802828175 2448 5-methyltetrahydrofolate--homocysteine methyltransferase NA K00548 Amino acid metabolism; Overview; Metabolism of cofactors and vitamins; Metabolism of other amino acids Overview 01230 Biosynthesis of amino acids COG0646;COG1410 E LFTS_00126 6367.06860739421 -0.313486616146334 0.123302577955318 -2.54241737151622 0.0110088627324544 0.0401290802828175 540 peptidoglycan-associated lipoprotein NA K03640 NA Translation 03010 Ribosome COG2885 M LFTS_01825 165.373697083404 -0.60545115162752 0.238318392061422 -2.54051374881498 0.0110689741566227 0.0402891211615871 1020 translation factor SUA5 NA K07566 NA Overview 01210 2-Oxocarboxylic acid metabolism COG0009 J LFTS_00587 1710.85883873217 0.386686693599912 0.152463368156972 2.53625968174723 0.01120436151014 0.0407190116571855 918 succinyl-CoA synthetase alpha subunit Reductive TCA cycle carbon dioxide fixation K01902 Carbohydrate metabolism; Overview; Energy metabolism Overview 01200 Carbon metabolism COG0074 C LFTS_01829 1254.1440093126 -0.540124906195394 0.21300180205845 -2.53577622806768 0.0112198402997474 0.0407190116571855 2481 hypothetical protein NA K09822 NA Energy metabolism 00190 Oxidative phosphorylation COG3002 S LFTS_00659 193.996293605283 0.491878635280644 0.194228001093193 2.53248055127044 0.0113258652642462 0.0410438790771373 723 phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein NA K02065 Membrane transport Membrane transport 02010 ABC transporters COG1127 M LFTS_01530 460.958097717443 0.459109129444362 0.18134986932686 2.53162095538584 0.0113536651158426 0.0410847328646064 1260 hypothetical protein NA NA NA NA NA NA NA LFTS_02080 669.724147837218 0.394291400168489 0.156211220607638 2.5240914105578 0.0115997761543711 0.0419143074415211 1296 adenine-specific DNA-methyltransferase NA K07316 NA Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG2189 L LFTS_01936 375.809772986263 0.463930002596729 0.183871723990457 2.52311770689009 0.0116319458824885 0.0419303438296226 495 putative nucleotide-binding protein NA K09767 NA Energy metabolism 00190 Oxidative phosphorylation COG1666 S LFTS_01440 353.425803790692 0.491590241057799 0.194848453890702 2.52293631918451 0.0116379474024294 0.0419303438296226 1068 tryptophanyl-tRNA synthetase NA K01867 Translation Translation 00970 Aminoacyl-tRNA biosynthesis COG0180 J LFTS_00590 1247.73816304733 -0.385204871470729 0.152849239066468 -2.52016217956583 0.0117300774360265 0.0422011179536353 243 putative regulatory protein%2C FmdB family NA K03059 Nucleotide metabolism; Transcription Nucleotide metabolism 00230 Purine metabolism COG1996 K LFTS_02109 776.465350239298 -0.42109814561104 0.16753901575044 -2.51343332611129 0.0119562375666938 0.042952610680348 858 hypothetical protein NA K07275 NA Membrane transport 02010 ABC transporters COG3047 M LFTS_00287 360.469925841884 0.463466724086141 0.184579544858029 2.51093220780569 0.0120412818531091 0.043195709504804 927 hypothetical protein NA NA NA NA NA NA NA LFTS_00101 967.348074149601 0.362512626249478 0.14449984776835 2.50874054089405 0.012116244359602 0.0434019934841076 462 Fur family transcriptional regulator%2C ferric uptake regulator NA K03711 NA Lipid metabolism 00600 Sphingolipid metabolism COG0735 P LFTS_01348 812.182450447373 -0.373424189494041 0.149085950227654 -2.50475775164476 0.012253528688377 0.0437682951230415 363 hypothetical protein NA NA NA NA NA NA NA LFTS_00280 58.1282774043814 0.683067016395919 0.272761858416306 2.50426148421888 0.0122707309253994 0.0437682951230415 120 hypothetical protein NA NA NA NA NA NA NA LFTS_00836 529.534379036252 0.427831312600301 0.170842468776999 2.50424449882394 0.0122713200727112 0.0437682951230415 786 S-adenosyl-l-methionine hydroxide adenosyltransferase NA K09134 NA Immune system 04621 NOD-like receptor signaling pathway COG1912 H LFTS_00786 1232.13680274995 -0.390197299417639 0.156094524845564 -2.49975007005332 0.0124280950837089 0.0442639604270777 1899 Excinuclease ABC subunit C NA K03703 Replication and repair Replication and repair 03420 Nucleotide excision repair COG0322 L LFTS_00498 999.41477360326 0.531499429712623 0.212801321511575 2.4976321854454 0.0125025842722373 0.0444655572257251 1671 maltose alpha-D-glucosyltransferase/ alpha-amylase NA K05343 Carbohydrate metabolism Carbohydrate metabolism 00500 Starch and sucrose metabolism COG0366 G LFTS_00588 5638.56928886624 0.357913890056861 0.143339599904794 2.49696448360808 0.0125261501776458 0.0444857276308962 462 peroxiredoxin (alkyl hydroperoxide reductase subunit C) Oxidative stress response K03564 NA Membrane transport 03070 Bacterial secretion system COG1225 O LFTS_00516 1581.65397054364 -0.334362116978002 0.134099713984076 -2.49338426641018 0.0126531826326355 0.0448727703633837 1776 Signal transduction histidine kinase Quorum sensing K10715 Cellular community - prokaryotes; Signal transduction Signal transduction 02020 Two-component system COG0642;COG0784 T LFTS_01665 7759.12065633662 0.444890975916324 0.178884745845633 2.48702578754389 0.0128816061245291 0.0456177675578053 5157 DNA-directed RNA polymerase subunit beta NA K03043 Nucleotide metabolism; Transcription Nucleotide metabolism 00230 Purine metabolism COG0085 K LFTS_02215 1399.53696718829 0.387258672040403 0.155922666872816 2.48365859696515 0.0130040413607432 0.0459858418532113 1218 Transposase (or an inactivated derivative) NA K07493 NA Overview 01200 Carbon metabolism COG3328 X LFTS_00610 532.198227696901 -0.381469294633596 0.153735708997971 -2.48133174211745 0.0130892490315364 0.0462214106426129 816 pyrroline-5-carboxylate reductase NA K00286 Amino acid metabolism; Overview Overview 01230 Biosynthesis of amino acids COG0345 E LFTS_01005 177.445046802635 -0.486616828469855 0.196186845685545 -2.4803743939582 0.0131244495214205 0.0462799737734063 135 hypothetical protein NA NA NA NA NA NA NA LFTS_00541 148.072248690888 -0.515498254181435 0.207941257390803 -2.47905711761958 0.0131730209470955 0.0463854533632854 1011 Glycosyltransferase involved in cell wall bisynthesis Extracellular polysaccharide production and export K00786 NA Cell motility 02030 Bacterial chemotaxis NA LFTS_01822 206.139657381944 -0.719178998919625 0.290233099698843 -2.47793583731791 0.0132144906437855 0.0464656629992231 2472 hypothetical protein NA K09822 NA Energy metabolism 00190 Oxidative phosphorylation COG3002 S LFTS_00780 1217.72215817262 0.399388365673225 0.161264925694833 2.47659783398282 0.0132641266884276 0.0465743205472188 657 peptidyl-prolyl cis-trans isomerase A (cyclophilin A) NA K03767 Drug resistance Drug resistance 01503 Cationic antimicrobial peptide (CAMP) resistance COG0652 O LFTS_01482 454.498870512946 0.47171621306374 0.190747653408202 2.47298566789842 0.0133989516320232 0.0469813734234269 138 hypothetical protein NA K08714 NA Metabolism of terpenoids and polyketides 00523 Polyketide sugar unit biosynthesis NA LFTS_01110 571.849813820834 -0.433973008528023 0.175640090529025 -2.47080838560777 0.013480802992373 0.0472017975197736 1347 putative transposase NA K07496 NA Signal transduction 02020 Two-component system COG0675 X LFTS_01813 246.968828397309 -0.482855042170564 0.195663705369702 -2.46778032368456 0.0135953724612865 0.0475359999138652 795 ABC-2 type transport system permease protein Lipopolysaccharide synthesis K09690 Membrane transport Membrane transport 02010 ABC transporters COG1682 GM LFTS_00751 1312.90578181022 0.469258003296351 0.190296570993926 2.46592989482363 0.0136658077935344 0.0477151659757395 603 outer membrane lipoprotein NA K07285 NA Energy metabolism 00190 Oxidative phosphorylation COG3065 M LFTS_01664 9448.13218505133 0.438573798111095 0.17804996162961 2.46320636127652 0.0137700636046341 0.0480117505205055 4758 DNA-directed RNA polymerase subunit beta' NA K03046 Nucleotide metabolism; Transcription Nucleotide metabolism 00230 Purine metabolism COG0086 K LFTS_00799 1162.92644734435 0.363871607651091 0.147828151244682 2.46145003226631 0.0138376671443195 0.0481798886845632 981 two-component system%2C chemotaxis family%2C response regulator CheV Chemotaxis K03415 Signal transduction; Cell motility Signal transduction 02020 Two-component system COG0784;COG0835 TNT LFTS_00711 440.803596291056 -0.384337070057537 0.156287343883087 -2.45916950476198 0.0139258850293501 0.0484192310251248 648 hypothetical protein NA NA NA NA NA NA NA LFTS_00441 122.216006013973 0.58081540467615 0.236338963735828 2.4575524724961 0.0139887373359966 0.0485698338230274 132 cyd operon protein YbgT Cytochrome bd K00426 Energy metabolism; Signal transduction Energy metabolism 00190 Oxidative phosphorylation COG1294 C LFTS_01313 713.398977826937 0.34240498529026 0.139374516655801 2.45672590302762 0.0140209618111539 0.0486138229602908 186 hypothetical protein NA K09791 NA Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG2835 S LFTS_01329 518.4567435022 -0.401451721688544 0.163811995824852 -2.45068573682343 0.0142584379052417 0.0493683518557531 1212 heptosyltransferase-2 Lipopolysaccharide synthesis K02843 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG0859 M LFTS_00775 289.151009458555 -0.429506076066223 0.175340827946556 -2.44954972037166 0.0143034960407313 0.0494554814426399 741 DNA replication and repair protein RecO NA K03584 Replication and repair Replication and repair 03440 Homologous recombination COG1381 L LFTS_00748 665.012841642973 0.402197231109456 0.164422347563879 2.44612266561392 0.0144401861758158 0.0498051779149008 378 hypothetical protein NA K06940 NA Overview 01200 Carbon metabolism COG0727 R LFTS_01561 593.73066586579 0.399300845770488 0.163245801560976 2.44600989399008 0.0144447036511036 0.0498051779149008 552 hypothetical protein NA NA NA NA NA NA NA LFTS_00930 601.697452329115 0.346511480334113 0.141935507869588 2.4413304713891 0.0146332570420347 0.0503854252167565 1137 tRNA-guanine transglycosylase NA K00773 NA Folding, sorting and degradation 03060 Protein export COG0343 J LFTS_00877 1921.16891847868 0.293753320967412 0.120364107201462 2.44053919226714 0.0146653545414697 0.0504261015077366 588 LPS export ABC transporter protein LptC NA K11719 NA Overview 01200 Carbon metabolism COG3117 M LFTS_00189 1047.92559696147 -0.339703038423441 0.139283836746323 -2.43892648536197 0.014730964689223 0.0505183035605159 1362 glycine dehydrogenase subunit 1 NA K00282 Carbohydrate metabolism; Overview; Amino acid metabolism Overview 01200 Carbon metabolism COG0403 E LFTS_02535 1380.21214293547 0.314894358575955 0.129125965087866 2.43866025211645 0.0147418207649892 0.0505183035605159 1050 aspartate-semialdehyde dehydrogenase NA K00133 Amino acid metabolism; Overview; Biosynthesis of other secondary metabolites Overview 01210 2-Oxocarboxylic acid metabolism COG0136 E LFTS_01219 1966.7758131601 -0.581342640805053 0.238413176450263 -2.43838301834098 0.0147531328982038 0.0505183035605159 2487 hypothetical protein NA K09822 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG3002 S LFTS_00846 1287.34267891024 0.338728814253874 0.13935413256933 2.4307051969582 0.0150694702948075 0.0515305407880213 687 RNase HII NA K03470 Replication and repair Replication and repair 03030 DNA replication COG0164 L LFTS_00233 398.983338565837 -0.382197779848943 0.157277764201625 -2.43008146630937 0.0150954293754376 0.0515484030595301 816 hypothetical protein NA NA NA NA NA NA NA LFTS_01823 73.7018689315421 -0.751848893409664 0.310653512823939 -2.42021693743335 0.0155112503314094 0.0528957041479888 867 hypothetical protein NA K02380 NA Energy metabolism 00190 Oxidative phosphorylation COG3058 CO LFTS_01824 132.077801070781 -0.595630930987347 0.24645320169266 -2.41681149563693 0.0156571231945932 0.0533200113174775 1677 dihydroxyacid dehydratase NA K01687 Metabolism of cofactors and vitamins; Amino acid metabolism; Overview Overview 01210 2-Oxocarboxylic acid metabolism COG0129 EG LFTS_01883 581.176370518084 -0.438965588121076 0.181760184657618 -2.41508110782323 0.0157317061362176 0.0534446327760546 1308 histidyl-tRNA synthetase NA K01892 Translation Translation 00970 Aminoacyl-tRNA biosynthesis COG0124 J LFTS_00935 3992.45721609845 -0.285440682791193 0.118196603984674 -2.41496517808757 0.0157367140756524 0.0534446327760546 1650 single-stranded-DNA-specific exonuclease NA K07462 Replication and repair Replication and repair 03410 Base excision repair COG0608 L LFTS_00844 1974.19770442171 -0.413819401988201 0.171638195412935 -2.41099832699019 0.015908921417164 0.0539557689537104 726 tRNA (guanine37-N1)-methyltransferase NA K00554 NA Overview 01220 Degradation of aromatic compounds COG0336 J LFTS_01339 201.909333279978 0.492764446077707 0.204536429628514 2.40917692253005 0.0159885450780824 0.0541519387794452 744 lipoprotein-releasing system ATP-binding protein NA K09810 Membrane transport Membrane transport 02010 ABC transporters COG1136 M LFTS_01192 72.0792039790653 -0.659095271937502 0.273751302035002 -2.40764250996414 0.0160558944334334 0.0543060592673678 795 thiamine transport system ATP-binding protein NA K02017 Membrane transport Membrane transport 02010 ABC transporters COG1118 P LFTS_02476 2207.84678129161 0.316975517113515 0.131682042772011 2.40712788502464 0.0160785384425379 0.0543087589241156 2931 Isoleucyl-tRNA synthetase NA K01870 Translation Translation 00970 Aminoacyl-tRNA biosynthesis COG0060 J LFTS_01133 27.555941171114 0.918700069025626 0.381896164465066 2.40562790231863 0.0161446994097957 0.0544499909603199 843 hypothetical protein NA NA NA NA NA NA NA LFTS_01310 545.231215313722 0.444543329332864 0.184826868362647 2.40518780235258 0.016164156608494 0.0544499909603199 1035 Glycosyltransferase involved in cell wall bisynthesis Lipopolysaccharide synthesis K07011 NA Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG1216 G LFTS_02150 1650.88526201544 0.518384775958624 0.215787315652817 2.40229493744971 0.0162925663982647 0.0548082815508605 1407 glucose-6-phosphate 1-dehydrogenase NA K00036 Carbohydrate metabolism; Metabolism of other amino acids; Overview; Cancers Overview 01200 Carbon metabolism COG0364 G LFTS_02124 6524.3852645858 -0.587246284886047 0.244710685341659 -2.399757428108 0.0164059395793938 0.0551150889113149 90 hypothetical protein NA NA NA NA NA NA NA LFTS_00977 284.452559806685 -0.410094626005368 0.170943626152098 -2.39900507106644 0.0164396870196338 0.055153929731187 2514 type IV secretion system protein VirB4 NA K03199 Membrane transport Membrane transport 03070 Bacterial secretion system COG3451 U LFTS_01478 113.503246652679 0.544121484609092 0.226928607204521 2.39776505620862 0.0164954417432741 0.0552663991560369 192 hypothetical protein NA K07301 NA Overview 01212 Fatty acid metabolism COG0530 P LFTS_02100 2157.29036022168 -0.343194745229797 0.143224694320563 -2.3961981336938 0.0165661326921106 0.0554285408783137 1473 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B NA K02434 Translation Translation 00970 Aminoacyl-tRNA biosynthesis COG0064 J LFTS_00121 728.937846908594 0.333185720420195 0.139140382588344 2.39460115188808 0.0166384533766783 0.0555533064675476 894 UDP-glucose pyrophosphorylase Extracellular polysaccharide production and export K00973 Biosynthesis of other secondary metabolites; Metabolism of terpenoids and polyketides Metabolism of terpenoids and polyketides 00523 Polyketide sugar unit biosynthesis COG1209 M LFTS_01899 705.742264394815 -0.386632885888022 0.161474598974809 -2.39438827123726 0.0166481147700414 0.0555533064675476 903 hypothetical protein NA K06923 NA Overview 01200 Carbon metabolism COG2607 R LFTS_00279 187.950650515065 0.450108527885107 0.188808554298617 2.38394139268299 0.0171283299377002 0.057079126307135 330 hypothetical protein NA NA NA NA NA NA NA LFTS_00393 225.201483159405 -0.492998402140459 0.206891343882936 -2.38288559051272 0.0171775319752746 0.0571664584879955 1293 MoxR-like ATPase NA K04748 NA Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG0714 R LFTS_02427 1460.97620516053 0.386583108038302 0.162415423896497 2.38021179740084 0.0173026898993551 0.0575059987831508 2094 hypothetical protein NA K07405 Carbohydrate metabolism Carbohydrate metabolism 00500 Starch and sucrose metabolism COG1449 G LFTS_01682 634.747157307983 0.380082662575677 0.159776704770582 2.37883653390791 0.0173673757192358 0.0576439199439523 171 hypothetical protein NA NA NA NA NA NA NA LFTS_01661 7253.72749767338 0.410678317191582 0.172854032171696 2.37586773089363 0.0175077374525975 0.0580323137428765 2079 translation elongation factor 2 (EF-2/EF-G) NA K02355 NA Membrane transport 03070 Bacterial secretion system COG0480 J LFTS_00016 421.760067829734 -0.453302730992318 0.191063319499578 -2.37252619801427 0.0176669102070183 0.0584819424429393 408 Plasmid maintenance system killer protein NA K07334 NA Replication and repair 03410 Base excision repair COG3549 V LFTS_00658 331.551791102757 0.402908462414704 0.169918739638929 2.37118320952044 0.0177312394460397 0.0586168367857111 777 phospholipid/cholesterol/gamma-HCH transport system permease protein NA K02066 Membrane transport Membrane transport 02010 ABC transporters COG0767 M LFTS_01008 625.449095336065 0.394900291430975 0.166875087536017 2.36644245262639 0.0179599661676376 0.0592941246915632 732 hypothetical protein NA NA NA NA NA NA NA LFTS_00021 384.817208822233 -0.450415631105451 0.190620406180798 -2.36289304030884 0.0181329021715486 0.059785669493992 672 ChrR Cupin-like domain-containing protein NA K07167 NA Cell growth and death 04112 Cell cycle - Caulobacter COG3806 T LFTS_02092 18.9228723412213 -0.924634400404048 0.39148454237907 -2.36186694571643 0.0181831669423196 0.0598719907531213 513 hypothetical protein NA NA NA NA NA NA NA LFTS_02356 1641.0087418097 0.293553523716791 0.124440892116748 2.35897958238184 0.0183252639911108 0.0602600612194463 1227 argininosuccinate synthase NA K01940 Amino acid metabolism; Overview; Cardiovascular diseases Overview 01230 Biosynthesis of amino acids COG0137 E LFTS_02214 202.915409276443 0.49142258481453 0.208468770803304 2.35729592936584 0.0184085702326052 0.0604540364574063 417 Nucleotidyl transferase AbiEii toxin%2C Type IV TA system NA NA NA NA NA NA NA LFTS_02360 2733.37413378416 0.289368447352271 0.12281300552994 2.3561710431533 0.0184644135401903 0.0605574301595161 1380 putative arabinose efflux permease%2C MFS family NA K08153 NA Metabolism of cofactors and vitamins 00130 Ubiquinone and other terpenoid-quinone biosynthesis COG0477 GEPR LFTS_00444 912.39476957002 0.63984558934125 0.271765551975603 2.35440284719636 0.0185524927054344 0.0607661355279446 453 hypothetical protein NA NA NA NA NA NA NA LFTS_01410 191.32328201683 0.455506447858977 0.193638561520797 2.35235401606749 0.0186550107828833 0.0610215221134842 1164 hypothetical protein NA K02067 Membrane transport Membrane transport 02010 ABC transporters COG1463 M LFTS_00701 732.926042718695 0.359575945840745 0.153172903831793 2.34751667459157 0.0188990272130591 0.0617384778602693 669 repressor LexA NA K01356 NA Energy metabolism 00190 Oxidative phosphorylation COG1974 KT LFTS_02317 749.276479354126 0.372562882028686 0.158938032713512 2.34407634011826 0.0190742668195225 0.0622291697025368 1653 Nif-specific regulatory protein Nitrate/nitrite regulation K02584 Signal transduction Signal transduction 02020 Two-component system COG3604 KT LFTS_00152 763.207314682927 0.333954503506283 0.14291670983861 2.33670719038665 0.0194544144127584 0.0633862047576899 942 Mechanosensitive ion channel NA K05802 NA Replication and repair 03440 Homologous recombination COG3264 M LFTS_01526 625.945193264383 0.378639312958209 0.162160602080081 2.33496489345312 0.0195452547838221 0.0635433284403417 927 UDP-glucuronate decarboxylase Extracellular polysaccharide production and export K08678 Carbohydrate metabolism Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG0451 M LFTS_00700 2342.58707328455 0.391011417605364 0.167497879459045 2.33442607672517 0.0195734226741366 0.0635433284403417 1446 NADH dehydrogenase subunit N NADH dehydrogenase K00343 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG1007 C LFTS_00160 696.769789700055 0.441951562509967 0.189328292987743 2.33431335346471 0.0195793200262678 0.0635433284403417 303 DsrE/DsrF-like family protein NA K06039 NA Overview 01210 2-Oxocarboxylic acid metabolism COG1553 P LFTS_00532 251.820165467867 -0.504808850239474 0.216973221852446 -2.32659517119017 0.0199868217936227 0.0647812763741148 1878 galactofuranosylgalactofuranosylrhamnosyl-N- acetylglucosaminyl-diphospho-decaprenol beta-1%2C5/1%2C6-galactofuranosyltransferase Extracellular polysaccharide production and export K07011 NA Metabolism of terpenoids and polyketides 00523 Polyketide sugar unit biosynthesis COG1216 G LFTS_00400 657.205436551921 -0.37813137986942 0.163139299713984 -2.31784358846924 0.0204578232032559 0.0661268348839843 255 hypothetical protein NA K07330 NA Cellular community - prokaryotes 02024 Quorum sensing COG3354 N LFTS_01438 782.538812966149 0.336514993491149 0.145188221926202 2.31778438379249 0.0204610422277088 0.0661268348839843 2037 ABC-type branched-chain amino acid transport system%2C substrate-binding protein NA K01999 Cellular community - prokaryotes; Membrane transport Membrane transport 02010 ABC transporters COG0683 E LFTS_01501 581.206976234315 0.357885475713962 0.154433821718602 2.31740347892235 0.0204817630171633 0.0661268348839843 774 phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein NA K02065 Membrane transport Membrane transport 02010 ABC transporters COG1127 M LFTS_00082 200.725234023571 -0.5030319704765 0.217346777387033 -2.31442111322747 0.020644633858915 0.0665662253868518 900 CHAD domain-containing protein NA K07031 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG2605 R LFTS_00963 754.000811416541 0.327816089754256 0.141794371900999 2.31191185770854 0.0207825411390333 0.0669240897300995 1416 cobyrinic acid a%2Cc-diamide synthase NA K02224 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG1797 H LFTS_00001 1379.37459486469 -0.410208629386481 0.17752169561761 -2.31075209122659 0.0208465521489039 0.0670433746988035 1398 chromosomal replication initiator protein DnaA NA K02313 Cell growth and death; Signal transduction Signal transduction 02020 Two-component system COG0593 L LFTS_01642 3068.05171690447 0.469208352877951 0.203196291138903 2.3091383718082 0.0209359040593373 0.067243743529086 759 methionine aminopeptidase%2C type I NA K01265 NA Translation 03010 Ribosome COG0024 J LFTS_00172 602.136418929529 0.352724479318754 0.153057579538895 2.30452147735107 0.021193388140543 0.0679829198934064 873 diaminopimelate epimerase NA K01778 Amino acid metabolism; Overview Overview 01230 Biosynthesis of amino acids COG0253 E LFTS_01295 393.520161752991 0.380744569115887 0.165307835343372 2.30324574951342 0.0212650200928103 0.0681247937509362 906 hypothetical protein NA K09949 NA Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG3494 S LFTS_02011 98.1708861469092 -0.573240865301891 0.249757355370375 -2.29519112440877 0.0217221736183074 0.0694997729924223 207 hypothetical protein NA NA NA NA NA NA NA LFTS_00406 592.969487702253 -0.384038443372901 0.167813829001584 -2.28847911794728 0.0221096348239492 0.0706485246431077 1212 hypothetical protein NA NA NA NA NA NA NA LFTS_02501 907.127787380443 -0.302147089358917 0.132077029279567 -2.28765812652679 0.022157438015953 0.0706512126221021 1818 tRNA uridine 5-carboxymethylaminomethyl modification enzyme NA K03495 NA Translation 00970 Aminoacyl-tRNA biosynthesis COG0445 J LFTS_01703 423.76707741429 0.377455424646723 0.16500865233127 2.28748868204164 0.0221673153037971 0.0706512126221021 1749 hypothetical protein NA NA NA NA NA NA NA LFTS_00421 4155.46606833859 -0.42388454217775 0.185685218571489 -2.28281252239016 0.0224414140204605 0.0714332333609025 1215 cysteine desulfurase Nitrogenase genes K04487 Metabolism of cofactors and vitamins; Folding, sorting and degradation Metabolism of cofactors and vitamins 00730 Thiamine metabolism COG1104 E LFTS_01189 106.322835182367 -0.563864828564415 0.247256299562667 -2.2804872092713 0.0225788085443207 0.0717786675718431 771 Molybdopterin or thiamine biosynthesis adenylyltransferase NA K11996 Folding, sorting and degradation Folding, sorting and degradation 04122 Sulfur relay system COG0476;COG0607 HP LFTS_01689 1508.56683789528 0.402820887946413 0.176877747502622 2.27739720588901 0.0227625168101318 0.0722702640996012 1095 GTP-binding protein NA K06942 NA Translation 03010 Ribosome COG0012 J LFTS_01804 395.171263805617 0.412464950669435 0.181194041101442 2.27637149744078 0.0228237841235284 0.0723723562896578 837 Transposase (or an inactivated derivative) NA K07493 NA Overview 01200 Carbon metabolism COG3328 X LFTS_00166 478.624713532084 -0.34107869290835 0.149966159151964 -2.27437106369262 0.0229436857253711 0.0726598760678631 1143 membrane fusion protein%2C Cu(I)/Ag(I) efflux system Copper/silver resistance K07798 Signal transduction Signal transduction 02020 Two-component system COG0845 MV LFTS_00542 141.309136810099 -0.512427491007237 0.225913194892177 -2.2682494984492 0.0233140040771986 0.0737386948294095 1803 hypothetical protein NA NA NA NA NA NA NA LFTS_00283 1528.10847817228 0.370120021648827 0.163271083762534 2.26690491126487 0.023396035148036 0.07390412119189 315 Heme-degrading monooxygenase HmoA NA K07145 NA Signal transduction 02020 Two-component system COG2329 H LFTS_00854 550.414690194404 0.35468470748436 0.156509655850369 2.26621613572172 0.0234381531762156 0.0739248884486363 2748 hypothetical protein NA K09118 NA Amino acid metabolism 00270 Cysteine and methionine metabolism COG1615 S LFTS_01397 24.6612325683703 -0.89059280048183 0.393082754697634 -2.26566235694285 0.0234720639799226 0.0739248884486363 120 hypothetical protein NA NA NA NA NA NA NA LFTS_00902 504.559733736006 -0.404834531663529 0.178708061143228 -2.2653400695734 0.0234918189358096 0.0739248884486363 885 tRNA dimethylallyltransferase NA K00791 Metabolism of terpenoids and polyketides Metabolism of terpenoids and polyketides 00908 Zeatin biosynthesis COG0324 J LFTS_01271 75.2811415666353 -0.65095400829259 0.288132841966973 -2.25921489493796 0.0238700207405577 0.0749447895873784 273 Nucleotidyl transferase AbiEii toxin%2C Type IV TA system NA NA NA NA NA NA NA LFTS_00300 1164.06289747593 0.399199206379341 0.176705993475055 2.25911525992294 0.0238762161517312 0.0749447895873784 627 hypothetical protein NA NA NA NA NA NA NA LFTS_01667 2620.20509298272 0.389280363100313 0.172365117880436 2.25846370708454 0.0239167647921094 0.0749572385528638 525 large subunit ribosomal protein L10 NA K02864 Translation Translation 03010 Ribosome COG0244 J LFTS_00819 1374.44120352184 0.301448311374104 0.13349744549371 2.2580829937177 0.0239404856842212 0.0749572385528638 1173 hypothetical protein NA NA NA NA NA NA NA LFTS_02057 3941.06160914676 -0.269442713443708 0.119373233781508 -2.25714513135229 0.0239990076037057 0.075045953336871 1032 Site-specific recombinase XerD NA K14059 NA Translation 03010 Ribosome COG0582 LX LFTS_02320 369.415395332644 0.369508413631714 0.163832418767056 2.25540473865002 0.024107935583736 0.0752918691723214 1209 putative ABC transport system permease protein NA K05685 Membrane transport Membrane transport 02010 ABC transporters COG0577;COG1136 VM LFTS_00545 181.656204339919 -0.433296572959664 0.19254941112046 -2.25031367501088 0.0244290404640817 0.0761989894525812 1962 Glycosyltransferase involved in cell wall bisynthesis Extracellular polysaccharide production and export K02844 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG0438 M LFTS_02110 465.497142718821 0.363826372612937 0.161743432029968 2.24940430685017 0.0244867848468878 0.0762833923926857 441 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily protein NA K07104 Xenobiotics biodegradation and metabolism; Overview Overview 01220 Degradation of aromatic compounds COG2514 Q LFTS_01860 184.238520648714 -0.438664486571269 0.195141441228922 -2.24793095617587 0.02458059287238 0.0764797920910345 318 hypothetical protein NA NA NA NA NA NA NA LFTS_02522 589.35183017924 0.367891359044014 0.163786578780828 2.24616303596102 0.0246935669271169 0.0767352592260157 1152 phosphate transport system substrate-binding protein NA K02040 Membrane transport; Signal transduction; Infectious diseases Membrane transport 02010 ABC transporters COG0226 P LFTS_01850 68.6314284070776 -0.626534370557349 0.279938910666722 -2.23811105453383 0.0252138139494678 0.0782541092114569 225 hypothetical protein NA NA NA NA NA NA NA LFTS_01584 1858.91084465314 -0.273400391472386 0.122235001471733 -2.23667843236875 0.0253073646084536 0.0784465192227127 882 TIGR00255 family protein NA NA NA NA NA NA NA LFTS_00015 1132.05499882973 0.342145590205111 0.153312719819817 2.23168430256291 0.0256358354484876 0.0793657371418932 786 putative transposase NA K07497 NA Replication and repair 03410 Base excision repair COG2801 X LFTS_01372 627.738965405621 -0.34997234132217 0.156861517065561 -2.23109114248779 0.0256750923563534 0.0793884074600679 1314 Adenylosuccinate lyase NA K01756 Amino acid metabolism; Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0015 F LFTS_00576 164.533580694484 -0.498640627436705 0.223559911883161 -2.23045636060775 0.0257171614937208 0.079419706178124 642 PEP-CTERM protein-sorting domain-containing protein NA NA NA NA NA NA NA LFTS_00968 587.521843326871 0.335002835576379 0.150345575936168 2.22821877857325 0.0258659294257918 0.0797800254994025 2400 diguanylate cyclase (GGDEF) domain-containing protein Genes encoding proteins with EAL and GGDEF domains K14051 Cellular community - prokaryotes Cellular community - prokaryotes 02024 Quorum sensing COG2199;COG2200;COG2202 T LFTS_00354 231.906862239385 -0.55002133432861 0.247492089045721 -2.222379456448 0.0262576724896199 0.0808879477189531 132 hypothetical protein NA NA NA NA NA NA NA LFTS_01319 224.628448052612 0.406008924968935 0.182909778294011 2.21972236124147 0.0264376199662798 0.0813414891536776 762 Diacylglycerol kinase family enzyme NA K07029 Lipid metabolism Lipid metabolism 00561 Glycerolipid metabolism COG1597 IR LFTS_00544 122.243847220959 -0.529360410494835 0.238643483195748 -2.21820601763772 0.0265407886318073 0.0815579734717837 1125 Glycosyltransferase involved in cell wall bisynthesis Extracellular polysaccharide production and export K02844 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG0438 M LFTS_01283 184.780720673427 -0.473061532076183 0.213514638220905 -2.21559297300613 0.0267193905522 0.0820054381639125 1104 DnaJ domain-containing protein NA K03686 NA Amino acid metabolism 00270 Cysteine and methionine metabolism COG0484 O LFTS_01844 279.29303137504 0.497256454548513 0.224685933037638 2.21311787447421 0.0268895200940024 0.0824258285495561 777 Tetratricopeptide repeat protein NA NA NA NA NA NA NA LFTS_02409 1647.83212901617 -0.369165534264334 0.167237032066178 -2.2074389248803 0.0272834094825883 0.0835302413469391 888 Heat shock protein. Metallo peptidase. MEROPS family M48B NA K03799 NA Energy metabolism 00190 Oxidative phosphorylation COG0501 O LFTS_00398 96.571469504292 -0.583630950331178 0.264898246829167 -2.2032269270078 0.0275787583367905 0.0842473174419584 492 Fe-S-cluster containining protein NA K06940 NA Signal transduction 02020 Two-component system COG0727 R LFTS_01590 1115.10120681621 -0.317805847851853 0.144251802815289 -2.20313258932921 0.027585404826128 0.0842473174419584 450 3-dehydroquinate dehydratase NA K03786 Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG0757 E LFTS_02289 276.461768239274 0.535119591493711 0.243059660984823 2.20159770373054 0.0276937382830713 0.0844743967751108 165 hypothetical protein NA NA NA NA NA NA NA LFTS_01836 217.473296932079 -0.473374931712724 0.215348876427645 -2.19817692836569 0.0279365001367918 0.0851104648775298 927 3-hydroxyisobutyrate dehydrogenase NA K00020 Amino acid metabolism Amino acid metabolism 00280 Valine, leucine and isoleucine degradation COG2084 I LFTS_02113 270.414894055688 -0.376246912623933 0.171264456390932 -2.1968768100084 0.0280292454649553 0.0852884996644785 840 Sir2 family protein NA K12410 NA Overview 01220 Degradation of aromatic compounds COG0846 O LFTS_02111 283.13720760512 0.372641789904051 0.169736622612111 2.19541183375391 0.0281340690045101 0.0854008067279777 354 DNA-binding transcriptional regulator%2C ArsR family NA K03892 NA Amino acid metabolism 00270 Cysteine and methionine metabolism COG0640 K LFTS_01419 271.259381812217 0.481181111440432 0.219176885862908 2.19540080399447 0.0281348594972702 0.0854008067279777 249 ORF6N domain-containing protein NA K06678 Cell growth and death Cell growth and death 04111 Cell cycle - yeast NA LFTS_01752 18.2368184823174 -0.876663481733366 0.399690634087679 -2.19335507756996 0.0282818062455226 0.0857421589345966 663 hydrogenase-4 component E NA K12140 NA Amino acid metabolism 00260 Glycine, serine and threonine metabolism NA LFTS_01657 2168.42242510526 0.369565746016574 0.168633459872382 2.19153272604532 0.0284132641964186 0.0860357792841617 657 large subunit ribosomal protein L4 NA K02926 Translation Translation 03010 Ribosome COG0088 J LFTS_01311 305.09083716225 0.370089914729394 0.169067927337568 2.18900131182454 0.0285967446717209 0.0864860185570536 999 heptosyltransferase-2 Lipopolysaccharide synthesis K02843 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG0859 M LFTS_00106 390.528675254539 0.385594637607768 0.176485857642414 2.18484723228668 0.0289000495907188 0.0872971121294375 1266 glutamate-5-semialdehyde dehydrogenase NA K00147 Amino acid metabolism; Overview; Biosynthesis of other secondary metabolites Overview 01230 Biosynthesis of amino acids COG0014 E LFTS_00499 1277.91401294122 0.470746200103366 0.215675491924646 2.18265967960717 0.0290608812977988 0.0876763967309804 1680 maltose alpha-D-glucosyltransferase/ alpha-amylase NA K05343 Carbohydrate metabolism Carbohydrate metabolism 00500 Starch and sucrose metabolism COG0366 G LFTS_00540 88.1613737624466 -0.56090216246511 0.257651990849673 -2.17697585264291 0.0294823691668875 0.0888402057562209 990 Glycosyltransferase%2C GT2 family Extracellular polysaccharide production and export K07011 NA Cell motility 02030 Bacterial chemotaxis COG1216 G LFTS_00321 66.3090888032735 -0.668787844694618 0.30774490412659 -2.17318901377978 0.0297660943084123 0.0895865743955364 354 small multidrug resistance family-3 protein NA K09771 NA Signal transduction 02020 Two-component system COG1742 R LFTS_00864 2048.45585143869 0.277161292480156 0.127658848518434 2.17110913733593 0.0299229235034242 0.0899496829861096 285 hypothetical protein NA NA NA NA NA NA NA LFTS_02173 820.024785725256 0.30710963047059 0.141595387479156 2.16892397371206 0.030088456317818 0.0903380463841734 1674 Formate-tetrahydrofolate ligase NA K01938 Metabolism of cofactors and vitamins; Energy metabolism; Overview Overview 01200 Carbon metabolism COG2759 F LFTS_00494 198.28331883438 -0.510467512147952 0.235461165718516 -2.16794778277024 0.030162659713996 0.0904515947515006 471 phosphohistidine phosphatase%2C SixA NA K08296 NA Carbohydrate metabolism 00500 Starch and sucrose metabolism COG2062 T LFTS_01512 2766.94253245865 0.384093550712925 0.17736679179343 2.16553249246487 0.0303469298666134 0.0908546330698496 1146 aspartate aminotransferase NA K00839 Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0075 EF LFTS_01196 48.3523620344478 -0.678789492305027 0.313495474975035 -2.16522899528002 0.0303701528885942 0.0908546330698496 1224 molybdopterin molybdotransferase NA K03750 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG0303 H LFTS_01911 2393.25896234238 0.413902626795659 0.191572997190065 2.16054784790475 0.0307302837135195 0.0917107595126643 636 Transglycosylase SLT domain-containing protein NA K08309 NA Nucleotide metabolism 00240 Pyrimidine metabolism COG0741 M LFTS_02189 910.969533333235 -0.323343417910845 0.149677276690929 -2.16027058388109 0.0307517287855171 0.0917107595126643 756 creatinine amidohydrolase NA K01470 Amino acid metabolism Amino acid metabolism 00330 Arginine and proline metabolism COG1402 HQ LFTS_01904 179.410220687949 0.433530352148274 0.200744469552725 2.15961293037967 0.0308026465930338 0.0917107595126643 552 hypothetical protein NA NA NA NA NA NA NA LFTS_02025 118.417300113649 -0.492842162113296 0.228210265695029 -2.15959681135428 0.030803895491985 0.0917107595126643 333 Cupin domain-containing protein NA K07167 NA Folding, sorting and degradation 04122 Sulfur relay system COG3806 T LFTS_00059 383.889194931371 0.369594808046444 0.171280381662995 2.15783503316594 0.0309406600395617 0.0919507921449169 747 phosphoglycolate phosphatase NA K01091 Carbohydrate metabolism Carbohydrate metabolism 00630 Glyoxylate and dicarboxylate metabolism COG0546 C LFTS_00947 625.010419077582 -0.345890264692886 0.160312075282774 -2.15760580781436 0.0309584927696281 0.0919507921449169 570 molecular chaperone GrpE NA K03687 NA Folding, sorting and degradation 03018 RNA degradation COG0576 O LFTS_00837 649.6646848492 0.385319942601934 0.179021821855363 2.15236298350961 0.0313687767559796 0.0930582088488847 768 Phospholipid methyltransferase NA K16168 NA Immune system 04621 NOD-like receptor signaling pathway COG1755 S LFTS_01771 690.373698330594 -0.425452207279431 0.197827208883988 -2.15062533450052 0.0315057840109181 0.0933532527427204 552 hypothetical protein NA K08760 Digestive system Digestive system 04975 Fat digestion and absorption NA LFTS_00423 679.892444254666 -0.32467830509546 0.151096232061783 -2.14881801263382 0.0316488289585789 0.0936654628464608 1068 PLD-like domain-containing protein NA K06131 Lipid metabolism Lipid metabolism 00564 Glycerophospholipid metabolism COG1502 I LFTS_01772 156.555774527657 -0.441104505918227 0.205324106835925 -2.14833276382258 0.0316873298869928 0.093667897858578 660 transcriptional regulator%2C TetR family NA K16137 NA Nucleotide metabolism 00230 Purine metabolism COG1309 K LFTS_00027 197.609032845077 -0.514074735726502 0.239349989366898 -2.14779510576238 0.0317300360028791 0.0936827428778592 189 Zn-finger domain of CDGSH type-containing protein NA NA NA NA NA NA NA LFTS_02265 549.822825687064 0.358519518718943 0.167211683674123 2.14410566798465 0.0320244210287194 0.0944397516932343 744 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase NA K01814 Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG0106 E LFTS_01700 1580.76983745914 0.261539124647558 0.122064185843107 2.14263604710167 0.0321423343038912 0.0946751695254425 612 ATP-dependent Clp protease%2C protease subunit NA K01358 Aging; Cell growth and death Cell growth and death 04112 Cell cycle - Caulobacter COG0740 O LFTS_02482 500.230658780336 -0.450486997385763 0.210501824667577 -2.14006219707202 0.0323497406157531 0.0951733197287128 321 hypothetical protein NA K03210 Cellular community - prokaryotes; Folding, sorting and degradation; Membrane transport Folding, sorting and degradation 03060 Protein export COG1862 U LFTS_01701 4204.55172391835 0.268301219480157 0.125408107168154 2.13942483894126 0.032401277062376 0.0952122633298662 1407 trigger factor NA K03545 NA Nucleotide metabolism 00240 Pyrimidine metabolism COG0544 O LFTS_02508 318.308970284119 0.346287613109759 0.162000850416335 2.13756663758131 0.0325519319092625 0.0955420339154977 834 hypothetical protein NA K07043 NA Cell growth and death 04112 Cell cycle - Caulobacter COG1451 R LFTS_01921 1786.89795892835 0.312107993855793 0.146097717314999 2.1362961693841 0.032655280923332 0.0957323447823154 600 pyrimidine operon attenuation protein / uracil phosphoribosyltransferase NA K02825 Nucleotide metabolism Nucleotide metabolism 00240 Pyrimidine metabolism COG2065 F LFTS_01443 993.125053587325 0.335949109205383 0.157326814562529 2.13535823590874 0.0327317593642328 0.0958435262420292 1950 DNA helicase-2 / ATP-dependent DNA helicase PcrA NA K03657 Replication and repair Replication and repair 03420 Nucleotide excision repair COG0210 L LFTS_00501 858.519972925003 0.34754149767739 0.162850764226723 2.13411032688516 0.032833750744301 0.0960290639415673 1161 diguanylate cyclase (GGDEF) domain-containing protein Putative diguanylate cyclases (GGDEF domain-containing proteins) K13069 NA Signal transduction 02020 Two-component system COG2199 T LFTS_01893 2106.68014233761 -0.271123366263603 0.127184247283619 -2.13173700402536 0.0330284729782439 0.0964850573724022 540 hypothetical protein NA NA NA NA NA NA NA LFTS_00267 372.205413543339 0.441168836074708 0.207148730104198 2.1297202056358 0.0331947198114463 0.0968568937221309 1131 Putative MetA-pathway of phenol degradation NA NA NA NA NA NA NA LFTS_01004 376.550173159898 -0.34094906044945 0.160730755451375 -2.12124343901684 0.0339013214485241 0.0988026789226624 186 hypothetical protein NA NA NA NA NA NA NA LFTS_02103 1220.66412280253 -0.326050510086622 0.153941295207841 -2.11801849300028 0.0341735015363926 0.0994793030672976 447 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C NA K02435 Translation Translation 00970 Aminoacyl-tRNA biosynthesis COG0721 J LFTS_02290 2051.32900481224 0.496560206656123 0.235328701131012 2.11007074049875 0.0348522631087985 0.101336521740904 1119 phosphate ABC transporter substrate-binding protein%2C PhoT family (TC 3.A.1.7.1) NA K02040 Membrane transport; Signal transduction; Infectious diseases Membrane transport 02010 ABC transporters COG0226 P LFTS_01927 383.153022851071 0.372333719071411 0.176587072554283 2.10849930114197 0.0349878231456819 0.101416406595651 507 hypothetical protein NA K14205 Infectious diseases; Drug resistance; Signal transduction Signal transduction 02020 Two-component system COG0392;COG2898 S LFTS_00674 576.648805603709 0.377160108413389 0.178920231888754 2.10797909454921 0.0350327977712729 0.101416406595651 336 hypothetical protein NA K15146 Endocrine system Endocrine system 04919 Thyroid hormone signaling pathway NA LFTS_00728 183.477586045934 -0.472739268406471 0.22426913205551 -2.10791054512781 0.0350387279119261 0.101416406595651 831 PEP-CTERM protein-sorting domain-containing protein NA NA NA NA NA NA NA LFTS_00375 992.335816082908 0.347222698880718 0.164776535014224 2.10723389013336 0.0350973106405871 0.101416406595651 264 small subunit ribosomal protein S20 NA K02968 Translation Translation 03010 Ribosome COG0268 J LFTS_02433 2214.98331070311 0.276587696892733 0.131265376499225 2.10708797909376 0.0351099541268975 0.101416406595651 1146 Xaa-Pro aminopeptidase NA K01262 NA Amino acid metabolism 00360 Phenylalanine metabolism COG0006 E LFTS_00028 535.966813931673 -0.42394678198694 0.201216356460204 -2.10692008067836 0.0351245076745193 0.101416406595651 486 hypothetical protein NA NA NA NA NA NA NA LFTS_00726 390.726817218407 -0.333814153090847 0.158560231297024 -2.10528296004771 0.0352666844937352 0.101708790778916 213 sulfur carrier protein NA K03154 Folding, sorting and degradation Folding, sorting and degradation 04122 Sulfur relay system COG2104 H LFTS_01996 997.345724294016 -0.339647084795124 0.161370560119133 -2.10476486258942 0.0353117812003643 0.101720843643228 1545 tRNA(Ile)-lysidine synthase NA K04075 NA Metabolism of cofactors and vitamins 00740 Riboflavin metabolism COG0037 J LFTS_02098 529.35674366333 -0.328508130831491 0.156331467211767 -2.10135641077618 0.0356096912925558 0.102460292307053 501 Tetraheme cytochrome c subunit of nitrate or TMAO reductase NA K15876 Energy metabolism Energy metabolism 00910 Nitrogen metabolism COG3005 C LFTS_02396 3028.56590793109 0.318797698628735 0.151847870217597 2.09945452756038 0.0357768522950164 0.102822259890648 327 hypothetical protein NA NA NA NA NA NA NA LFTS_00988 178.6701991459 0.506035172436868 0.241156189581671 2.09837107359623 0.0358723785063145 0.102893266668628 195 hypothetical protein NA NA NA NA NA NA NA LFTS_02069 472.531236533893 -0.446101947746562 0.2126081290035 -2.09823561233267 0.0358843371688258 0.102893266668628 1005 alcohol dehydrogenase%2C propanol-preferring NA K13953 Amino acid metabolism; Carbohydrate metabolism; Metabolism of cofactors and vitamins; Xenobiotics biodegradation and metabolism; Lipid metabolism; Overview Overview 01220 Degradation of aromatic compounds COG1064 G LFTS_00078 1627.94806053759 0.374971340024777 0.17892042032602 2.09574367946108 0.0361049348688726 0.103406530050711 780 carboxymethylenebutenolidase NA K01061 Xenobiotics biodegradation and metabolism Xenobiotics biodegradation and metabolism 00364 Fluorobenzoate degradation COG0412 Q LFTS_01895 488.787794348738 -0.325891643730597 0.155600991383492 -2.09440595996852 0.0362238323028199 0.103627672157434 1812 DNA ligase-1 NA K10747 Replication and repair Replication and repair 03030 DNA replication COG1793 L LFTS_00839 1572.42028781265 0.316861686334846 0.151373347273816 2.09324621567416 0.0363271811175841 0.103803876158982 888 protease-4 Chaperones K04773 NA Translation 03010 Ribosome COG0616 O LFTS_01593 1005.25094066992 0.28160208644619 0.134808603616505 2.08890292527081 0.0367164624749482 0.104795781530105 1371 acetyl-CoA carboxylase%2C biotin carboxylase subunit NA K01961 Carbohydrate metabolism; Overview; Energy metabolism; Lipid metabolism Overview 01200 Carbon metabolism COG0439 I LFTS_00688 2979.44652880075 0.262133398776481 0.125785363534053 2.08397377414675 0.0371625528717337 0.105947369769645 537 NADH dehydrogenase subunit B NADH dehydrogenase K00331 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG0377 C LFTS_00091 1654.6481783544 0.291076744579272 0.139849673278905 2.08135448410217 0.0374014715531055 0.106506366874021 528 translation initiation factor IF-3 NA K02520 NA Translation 00970 Aminoacyl-tRNA biosynthesis COG0290 J LFTS_00216 40.0651454380341 -0.833398593621437 0.401158853895514 -2.07747775109185 0.0377574866382938 0.107286848516066 270 flagellar biosynthetic protein FliQ Motility K02420 Cell motility Cell motility 02040 Flagellar assembly COG1987 N LFTS_01768 845.999992727579 -0.306378324525424 0.147479473419668 -2.07743028518682 0.0377618634157514 0.107286848516066 567 Endonuclease%2C Uma2 family (restriction endonuclease fold) NA NA NA NA NA NA NA LFTS_01421 138.711172764803 0.42885525102298 0.206497905569295 2.07680194063309 0.0378198430431496 0.10732891530282 225 hypothetical protein NA K05929 Lipid metabolism Lipid metabolism 00564 Glycerophospholipid metabolism NA LFTS_01067 66.4993352336688 0.543178150390049 0.261746279268294 2.07520867883391 0.037967198628575 0.107624236933452 285 Homeodomain-like domain-containing protein NA K11686 NA Translation 03010 Ribosome COG0789 K LFTS_02524 1369.22769247686 0.269812987904277 0.130051096569502 2.07466907255244 0.0380172156203788 0.107643277941073 1179 ribulose-bisphosphate carboxylase large chain Calvin-Benson-Bassham cycle carbon dioxide fixation K01601 Carbohydrate metabolism; Energy metabolism; Overview Overview 01200 Carbon metabolism COG1850 G LFTS_00884 1531.88747648878 0.295115324869485 0.142292201593479 2.07400912744757 0.0380784631804782 0.107694038073571 1206 chorismate synthase NA K01736 Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG0082 E LFTS_00702 423.777561441705 0.367962069149921 0.177492587194061 2.07311231960133 0.0381618277457078 0.107807163381624 471 hypothetical protein NA K08216 NA Overview 01220 Degradation of aromatic compounds NA LFTS_02495 1072.24663583775 0.356622046999533 0.172260906138173 2.07024364955727 0.0384295335794178 0.108440204856337 798 exonuclease%2C DNA polymerase III%2C epsilon subunit family NA K02342 Replication and repair; Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0847 L LFTS_02354 1307.10444717181 -0.284680174159364 0.137952928859229 -2.06360369811256 0.0390553066833498 0.110081057159646 1245 diaminopimelate decarboxylase NA K01586 Amino acid metabolism; Overview Overview 01230 Biosynthesis of amino acids COG0019 E LFTS_01358 1274.74709264799 -0.288223046794951 0.139802528736799 -2.0616440160219 0.039241640191125 0.110480993788377 1635 (R)-citramalate synthase NA K01649 Amino acid metabolism; Overview; Carbohydrate metabolism Overview 01210 2-Oxocarboxylic acid metabolism COG0119 E LFTS_01707 1252.20242842665 -0.296570229924018 0.144016334613371 -2.05928189132292 0.0394672421943957 0.110957476379577 831 6-phosphogluconolactonase NA K01057 Carbohydrate metabolism; Overview Overview 01200 Carbon metabolism COG0363 G LFTS_00699 2158.32765595308 0.392809627790516 0.19081999629598 2.05853493038135 0.0395388117438979 0.110957476379577 1503 NADH-quinone oxidoreductase subunit M NADH dehydrogenase K00342 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG1008 C LFTS_02420 885.786057615916 0.408687780091906 0.198539325988078 2.05847268825949 0.0395447803991573 0.110957476379577 1368 two-component system%2C NtrC family%2C response regulator AtoC NA K07714 Signal transduction Signal transduction 02020 Two-component system COG2204 T LFTS_00232 832.996963889562 0.271199239447314 0.131886093211052 2.05631414840171 0.0397522454127788 0.111413846782602 561 hypothetical protein NA K13999 Folding, sorting and degradation Folding, sorting and degradation 04141 Protein processing in endoplasmic reticulum NA LFTS_01612 2387.61811502086 -0.25360511189795 0.123652735021886 -2.05094623950747 0.0402721824541158 0.112743970248797 774 Ferredoxin-NADP reductase NA K00523 Carbohydrate metabolism Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG0543 HC LFTS_01704 1797.83387478714 0.290450486985856 0.141729496666987 2.0493298418205 0.0404298724895927 0.113058113621066 1488 glucose-6-phosphate 1-dehydrogenase NA K00036 Carbohydrate metabolism; Metabolism of other amino acids; Overview; Cancers Overview 01200 Carbon metabolism COG0364 G LFTS_01437 530.708939642547 0.329808586469006 0.160982666358243 2.04872110724682 0.0404893940336606 0.113097341087281 399 hypothetical protein NA K09449 NA NA NA NA LFTS_02003 55.7594880247685 0.621047183452397 0.303539793012937 2.04601570452388 0.0407548255823738 0.113710994834771 1173 Putative ammonia monooxygenase NA K07120 NA Membrane transport 02060 Phosphotransferase system (PTS) COG3180 R LFTS_01156 81.4978909655693 -0.697240734310104 0.341040655645925 -2.04445048637835 0.0409090641043636 0.114013378210143 393 MerC mercury resistance protein Mercury resistance NA NA NA NA NA NA LFTS_01586 1874.32463763741 0.323315706946795 0.158294709902564 2.04249217896042 0.0411027344429406 0.114208422640511 708 guanylate kinase NA K00942 Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0194 F LFTS_00888 1358.17751420494 0.270045364402144 0.132218162354097 2.04242261119111 0.0411096287355968 0.114208422640511 1266 GAF domain-containing protein NA K08484 Membrane transport Membrane transport 02060 Phosphotransferase system (PTS) COG3605 T LFTS_00777 413.547785852771 0.377123394473325 0.184698038252415 2.04183757467924 0.0411676456904606 0.114208422640511 999 hypothetical protein NA NA NA NA NA NA NA LFTS_00316 51.4352001460088 -0.642299616601966 0.314612164746558 -2.04156001761528 0.041195194745037 0.114208422640511 705 hypothetical protein NA NA NA NA NA NA NA LFTS_01989 1350.94428074042 -0.305926818250171 0.149872686306591 -2.04124464429992 0.0412265162207507 0.114208422640511 1560 Glutathionylspermidine synthase preATP-grasp Spermidine NA NA NA NA NA NA LFTS_02068 538.33847061789 -0.38930897186533 0.190754394848626 -2.04089123175521 0.0412616395498533 0.114208422640511 3195 DNA helicase/exodeoxyribonuclease V%2C gamma subunit NA K03583 Replication and repair Replication and repair 03440 Homologous recombination COG1330 L LFTS_00668 1013.22224651503 -0.276657042854037 0.135583020642092 -2.04049918303818 0.0413006323225339 0.114208422640511 2289 DNA segregation ATPase FtsK/SpoIIIE%2C S-DNA-T family NA K03466 NA Folding, sorting and degradation 03018 RNA degradation COG1674 D LFTS_01589 4360.79840358382 0.263909494371 0.129464421667026 2.03847119519645 0.0415028325921414 0.114640046471182 1395 Tetratricopeptide repeat-containing protein NA K12600 Folding, sorting and degradation Folding, sorting and degradation 03018 RNA degradation COG0457 R LFTS_02239 2562.88488010705 0.296415714881082 0.14593249184654 2.03118381061284 0.0422363520364503 0.116536704952958 498 hypothetical protein NA K08973 NA Metabolism of cofactors and vitamins 00785 Lipoic acid metabolism COG1981 S LFTS_00129 916.134864852205 0.333719133706089 0.164706755744649 2.02614113912526 0.0427503233776518 0.117824061992065 357 hypothetical protein NA NA NA NA NA NA NA LFTS_01207 41.0130851566305 -0.720161777968499 0.355776100719362 -2.02419942349238 0.0429496368869202 0.118242300443946 276 putative HTH-type transcriptional regulator YbaQ NA K07728 NA Translation 00970 Aminoacyl-tRNA biosynthesis COG1395 K LFTS_01843 1083.98520071575 -0.544907152270651 0.269340335261267 -2.02311752431019 0.0430610322014354 0.118417838553947 447 hypothetical protein NA NA NA NA NA NA NA LFTS_00339 2100.2382093776 0.276458932165461 0.136802278243708 2.0208649718023 0.0432937448202934 0.118926242677624 690 proteasome alpha subunit NA K03432 Folding, sorting and degradation Folding, sorting and degradation 03050 Proteasome COG0638 O LFTS_00681 4196.72449239254 -0.239293274724554 0.118499592851749 -2.0193594675378 0.0434498711411732 0.119223377104809 1893 1-deoxy-D-xylulose-5-phosphate synthase NA K01662 Metabolism of terpenoids and polyketides; Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00730 Thiamine metabolism COG1154 HI LFTS_01316 314.870297660885 -0.347832580352342 0.172663878229007 -2.01450693636688 0.043956337359719 0.120480104383971 723 Polysaccharide deacetylase Lipopolysaccharide synthesis K11931 Cellular community - prokaryotes Cellular community - prokaryotes 02026 Biofilm formation - Escherichia coli COG0726 GM LFTS_02383 419.378293137587 0.379760210137838 0.189023897734385 2.00905924959538 0.0445308506098693 0.121803703354655 1557 phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein NA K02067 Membrane transport Membrane transport 02010 ABC transporters COG1463 M LFTS_00814 1134.77823456927 -0.283741833843049 0.141235424976575 -2.00899904461016 0.0445372350560665 0.121803703354655 1557 NAD(P)H-hydrate epimerase NA K12615 Folding, sorting and degradation Folding, sorting and degradation 03018 RNA degradation NA LFTS_01864 402.523098784314 0.393213817092662 0.195974894839793 2.00644994561221 0.0448082640721088 0.122368686941045 984 Small-conductance mechanosensitive channel NA K16052 NA Glycan biosynthesis and metabolism 00550 Peptidoglycan biosynthesis COG0668 M LFTS_00801 487.792333212924 -0.314556659882519 0.156797661584333 -2.0061310653752 0.0448422662121047 0.122368686941045 228 hypothetical protein NA K02027 NA Translation 03010 Ribosome COG1653;COG2182 G LFTS_00402 919.939925426209 -0.294555197953879 0.146891184658128 -2.00526123224767 0.0449351270130433 0.122487637888625 372 hypothetical protein NA K02282 NA Translation 00970 Aminoacyl-tRNA biosynthesis COG4963 UW LFTS_01487 2167.10452649826 0.293099544722626 0.146218240773795 2.00453475005258 0.0450128083248551 0.122564996161654 1362 NADH-quinone oxidoreductase subunit F NADH dehydrogenase K00335 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG1894 C LFTS_00346 566.7102285078 0.360683375390948 0.180023230824868 2.00353795306469 0.0451195781178391 0.122721303283313 444 Sel1 repeat-containing protein NA K07126 NA Overview 01210 2-Oxocarboxylic acid metabolism COG0790 T LFTS_02026 36.0519088262934 0.673135449228483 0.336236655016346 2.00196926535496 0.0452880371590924 0.123044874729512 300 hypothetical protein NA NA NA NA NA NA NA LFTS_00170 687.154941291904 0.319524418895861 0.159819507223357 1.99928296893888 0.0455777458334183 0.12369680801515 744 NAD(P)-dependent dehydrogenase%2C short-chain alcohol dehydrogenase family NA K00059 Lipid metabolism; Overview; Metabolism of cofactors and vitamins Overview 01212 Fatty acid metabolism COG1028 IQR LFTS_01722 1048.46816626809 0.289452173683537 0.14487064148104 1.9980043625431 0.0457161871613078 0.123937231497286 1713 chloride channel protein%2C CIC family NA K03281 NA Folding, sorting and degradation 03018 RNA degradation COG0038 P LFTS_01483 1446.39122557584 0.274530084814572 0.137691274244957 1.99380887656087 0.0461729451469831 0.125039152108279 714 CRP/FNR family transcriptional regulator%2C anaerobic regulatory protein NA K10914 Cellular community - prokaryotes; Signal transduction Signal transduction 02020 Two-component system COG0664 T LFTS_00931 221.008978403094 0.416753294853201 0.209442959112413 1.98981764113407 0.0466110273980544 0.12595270850399 291 preprotein translocase subunit YajC NA K03210 Cellular community - prokaryotes; Folding, sorting and degradation; Membrane transport Folding, sorting and degradation 03060 Protein export COG1862 U LFTS_01569 435.871131628919 -0.30612054799013 0.153843935997449 -1.9898122471022 0.0466116218116132 0.12595270850399 840 cobalt-precorrin 4 C11-methyltransferase NA K05936 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG2875 H LFTS_00611 342.917649945111 -0.374736909710815 0.188932280179022 -1.98344565235615 0.0473176720265394 0.127601447272202 219 YggT family protein NA K02221 NA Overview 01230 Biosynthesis of amino acids COG0762 S LFTS_00060 540.220450770213 0.292926889775764 0.147690375557345 1.98338509649213 0.047324430565153 0.127601447272202 495 hypothetical protein NA NA NA NA NA NA NA LFTS_01108 92.3660965468623 0.506672631178216 0.255558573746061 1.98260861982145 0.0474111637919621 0.127696807352999 444 hypothetical protein NA NA NA NA NA NA NA LFTS_01798 1101.95021957159 0.316218341373634 0.159562342967942 1.98178552339989 0.0475032503945865 0.127806364156864 786 putative transposase NA K07497 NA Infectious diseases 05132 Salmonella infection COG2801 X LFTS_00332 1566.78239765727 -0.384792040001381 0.194265624928983 -1.98075207665818 0.0476190835215094 0.12792026372222 609 hypothetical protein NA K07337 NA Folding, sorting and degradation 03050 Proteasome COG3417 M LFTS_00993 129.622903085849 -0.466383384367582 0.235488887710447 -1.98048998788019 0.0476484972674078 0.12792026372222 225 hypothetical protein NA NA NA NA NA NA NA LFTS_02428 1623.47400207589 0.286719625999946 0.144882166804988 1.97898493874592 0.0478177020199477 0.128174489335957 2154 Alpha-amylase/alpha-mannosidase%2C GH57 family NA K07405 Carbohydrate metabolism Carbohydrate metabolism 00500 Starch and sucrose metabolism COG1449 G LFTS_01817 198.301182463353 0.486681796144411 0.245956532673126 1.97873091987033 0.0478463097762542 0.128174489335957 111 hypothetical protein NA NA NA NA NA NA NA LFTS_01236 63.8022860711613 0.536142003541124 0.271229507689954 1.97670971756507 0.0480744517500729 0.128526763448193 315 Cupin domain protein NA K00450 Amino acid metabolism Amino acid metabolism 00350 Tyrosine metabolism NA LFTS_01794 267.939045218236 0.344286199026686 0.174176615013524 1.97664995958242 0.0480812107831134 0.128526763448193 300 Transposase (or an inactivated derivative) NA K07493 NA Signal transduction 02020 Two-component system COG3328 X LFTS_00776 375.988498525007 0.347339483721129 0.17594272600485 1.97416222658477 0.0483632995821273 0.129141957853027 654 hypothetical protein NA NA NA NA NA NA NA LFTS_01424 74.8419685717415 0.522014471078818 0.264521469281368 1.97342950081514 0.0484466492952779 0.129171508596027 417 Transposase NA K07485 NA Overview 01200 Carbon metabolism COG3464 X LFTS_00761 1027.97603551392 -0.270770518169805 0.137227422959751 -1.97315166553279 0.0484782854063126 0.129171508596027 2703 long-chain acyl-CoA synthetase NA K01897 Cell growth and death; Cellular community - prokaryotes; Transport and catabolism; Lipid metabolism; Endocrine system; Overview Overview 01212 Fatty acid metabolism COG0318;COG1022 IQ LFTS_00080 43.4322813922272 0.690051299073057 0.349985143931438 1.97165882906229 0.0486485665651966 0.129486441628564 936 UDP-2%2C3-diacylglucosamine pyrophosphatase LpxH Lipopolysaccharide synthesis K03269 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG2908 M LFTS_00512 727.136447560439 -0.338206962089696 0.17166548048711 -1.97015125656023 0.0488210379949784 0.129806524551354 1212 Rhodopirellula transposase DDE domain-containing protein NA K07499 NA Signal transduction 02020 Two-component system COG3415 X LFTS_02268 793.705846451282 0.30133358578939 0.1531017864715 1.96819118009105 0.0490460447065164 0.130265456346581 1080 histidinol-phosphate aminotransferase NA K00817 Overview; Amino acid metabolism; Biosynthesis of other secondary metabolites Overview 01230 Biosynthesis of amino acids COG0079 E LFTS_00288 601.04812768132 0.324993415167707 0.16517894646365 1.96752323540958 0.0491229198862123 0.130330393636205 834 serine protease%2C ClpP class NA K07403 NA Signal transduction 02020 Two-component system COG1030 O LFTS_00845 1559.4772097631 0.335418091747287 0.170616327210976 1.96592024474026 0.0493078241290532 0.130681504034996 357 large subunit ribosomal protein L19 NA K02884 Translation Translation 03010 Ribosome COG0335 J LFTS_00452 118.628834454943 0.625798195802586 0.318550920695063 1.96451542013165 0.0494703498153006 0.130972619425812 618 K+-transporting ATPase ATPase C chain Role of potassium in the internal positive membrane potential K01548 Signal transduction Signal transduction 02020 Two-component system COG2156 P LFTS_00135 103.278548611819 -0.480393733233156 0.244938603909223 -1.96128223794072 0.049846108113646 0.131693607399355 2169 hypothetical protein NA K02027 NA Signal transduction 02020 Two-component system COG1653;COG2182 G LFTS_01130 156.967609330256 0.411858161705956 0.209996648643524 1.96126064090241 0.0498486261314534 0.131693607399355 975 hypothetical protein NA NA NA NA NA NA NA LFTS_01418 316.697860036115 0.374576930322833 0.191093091501943 1.96018038841045 0.0499747098852762 0.131858579230404 225 ORF6N domain-containing protein NA NA NA NA NA NA NA LFTS_01260 294.991032109211 0.331042881504095 0.168915177370968 1.95981726838593 0.0500171521376794 0.131858579230404 423 putative nucleic acid-binding protein%2C contains PIN domain NA K07064 NA Overview 01200 Carbon metabolism COG1848 R LFTS_01802 283.660632065769 0.397170336339622 0.2033273696034 1.95335402761725 0.050777659664631 0.133721675769357 525 DNA replication protein DnaC NA K02315 NA Overview 01200 Carbon metabolism COG1484 L LFTS_02208 342.464716676974 -0.354748446184946 0.182075471954199 -1.94835933900082 0.051371981518752 0.135143646619701 177 hypothetical protein NA NA NA NA NA NA NA LFTS_00502 116.150350217152 -0.451221572925231 0.231742926258603 -1.94707808436712 0.0515253739899135 0.135403889787447 843 PEP-CTERM protein-sorting domain-containing protein NA K02568 Energy metabolism Energy metabolism 00910 Nitrogen metabolism COG3043 CP LFTS_02410 1642.03538956045 -0.302783019023456 0.155596690633421 -1.9459476791624 0.0516610248028635 0.135617009144581 960 methionyl-tRNA formyltransferase NA K00604 Translation; Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00670 One carbon pool by folate COG0223 J LFTS_01153 67.9124079036553 -0.632326124140761 0.325227942256908 -1.94425521913264 0.051864681871706 0.136008015963145 540 hypothetical protein NA NA NA NA NA NA NA LFTS_01338 864.784316746212 0.288202818967639 0.148470500641975 1.94114533002497 0.0522406520904019 0.136849590196775 1212 aspartate aminotransferase NA K00812 Amino acid metabolism; Overview; Biosynthesis of other secondary metabolites Overview 01210 2-Oxocarboxylic acid metabolism COG0436 E LFTS_00120 515.662248153707 0.31152500699131 0.160526812086012 1.94064158468674 0.0523017663872205 0.136865464461716 615 dephospho-CoA kinase NA K00859 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00770 Pantothenate and CoA biosynthesis COG0237 H LFTS_01656 1838.8468219146 0.442688305533403 0.228306141474168 1.93901181402731 0.0524998996256078 0.13705553970135 288 large subunit ribosomal protein L23 NA K02892 Translation Translation 03010 Ribosome COG0089 J LFTS_01628 2000.4406165309 0.29811785860154 0.153768495738026 1.93874471601413 0.0525324308335796 0.13705553970135 1833 Putative Zn-dependent protease%2C contains TPR repeats NA K11739 NA Membrane transport 03070 Bacterial secretion system COG0457 R LFTS_02490 979.220418731167 -0.363369793561593 0.187431134736232 -1.93868427501629 0.0525397945838241 0.13705553970135 447 hypothetical protein NA K08999 NA Folding, sorting and degradation 04122 Sulfur relay system COG1259 R LFTS_01986 1065.20731293524 0.251932072687978 0.130072590973498 1.93685749474544 0.0527627654929702 0.137492908821304 1101 dCTP deaminase NA K01494 Nucleotide metabolism Nucleotide metabolism 00240 Pyrimidine metabolism COG0717 F LFTS_00249 433.657102942696 0.313110354944996 0.161705402721563 1.93630113573963 0.0528308297857471 0.137526118164782 1734 NitT/TauT family transport system permease protein NA K02050 NA Translation 03010 Ribosome COG0600 P LFTS_00992 163.323805873213 -0.442407604839776 0.228736508952307 -1.93413638629949 0.0530963612275511 0.138035249436662 855 CRISPR/Cas system-associated exonuclease Cas4%2C RecB family NA K07465 NA Energy metabolism 00920 Sulfur metabolism COG2887 L LFTS_01932 483.192952180846 0.377113259596523 0.195037883189455 1.93353851790016 0.0531698928612668 0.138035249436662 264 hypothetical protein NA NA NA NA NA NA NA LFTS_00616 4781.56784409317 -0.216340633437471 0.11190791390797 -1.93320227214122 0.053211284977606 0.138035249436662 2052 squalene-hopene/tetraprenyl-beta-curcumene cyclase NA K06045 Metabolism of terpenoids and polyketides Metabolism of terpenoids and polyketides 00909 Sesquiterpenoid and triterpenoid biosynthesis COG1657 I LFTS_02205 863.087305171891 -0.268466269627147 0.138892992147406 -1.93290003675799 0.0532485133587124 0.138035249436662 984 Site-specific recombinase XerD NA K04763 NA Metabolism of cofactors and vitamins 00130 Ubiquinone and other terpenoid-quinone biosynthesis COG0582 LX LFTS_00447 577.337261709329 0.417802723798365 0.21623822895506 1.9321408883958 0.053342118777307 0.138133861750401 1272 ADP-heptose:LPS heptosyltransferase NA K02843 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG0859 M LFTS_01490 365.485131746 -0.32094020150562 0.166582813109695 -1.92661052790771 0.0540281856364725 0.139764900616306 666 putative dithiol-disulfide isomerase%2C DsbA family NA K07396 NA Overview 01200 Carbon metabolism COG3531 O LFTS_01830 687.192546837971 -0.341218489321035 0.177746128062705 -1.91969576519079 0.0548963394818406 0.141863097663052 2025 PAS domain S-box-containing protein NA K07710 Signal transduction Signal transduction 02020 Two-component system COG0642 T LFTS_02048 37.4237503529599 0.61426244037403 0.320140595847397 1.91872711034383 0.0550188786641203 0.142032120829702 285 Cu and Ag efflux protein CusF Copper/silver resistance K07810 Signal transduction Signal transduction 02020 Two-component system COG5569 P LFTS_02085 409.202723786558 -0.342160453943106 0.178613373644634 -1.91564857077199 0.0554098427463537 0.142893017704808 879 hypothetical protein NA NA NA NA NA NA NA LFTS_02293 118.307300331322 0.641492132655437 0.33539877141679 1.91262517136139 0.055796054881471 0.143739888534028 1644 hypothetical protein NA NA NA NA NA NA NA LFTS_02493 7805.2134068801 -0.42385633145206 0.221931723032658 -1.90985013615961 0.0561525118493693 0.144508431115458 138 hypothetical protein NA NA NA NA NA NA NA LFTS_00749 1428.95265858418 -0.315307447617006 0.165314838671467 -1.90731485540522 0.0564798276462755 0.145200466937581 3246 Multidrug efflux pump subunit AcrB NA K03296 NA Overview 01200 Carbon metabolism COG0841 V LFTS_00642 709.910609712109 -0.301928265712737 0.158413361178651 -1.90595201986932 0.0566564309648793 0.145466259128436 669 hypothetical protein NA NA NA NA NA NA NA LFTS_00478 124.759128975564 -0.426902647500116 0.224023617721338 -1.90561446977049 0.0567002434012288 0.145466259128436 507 hypothetical protein NA K01850 Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids NA LFTS_02050 403.241294792765 0.352341011841608 0.185514653749123 1.89926242871406 0.0575299801586008 0.147442815128125 2319 Cu+-exporting ATPase Copper resistance K01533 NA Overview 01200 Carbon metabolism COG2217 P LFTS_01431 100.212728561344 -0.480086600134341 0.253829079746702 -1.89137746003501 0.058573975226285 0.149957335253123 654 Transposase DDE domain group 1 NA NA NA NA NA NA NA LFTS_00353 358.41808775069 0.35018056738319 0.18518817578572 1.89094452654677 0.0586317497449862 0.149957335253123 459 hypothetical protein NA K08976 NA Amino acid metabolism 00260 Glycine, serine and threonine metabolism COG2322 S LFTS_01534 2297.20352235794 0.327496424069505 0.173311716711601 1.88963810574027 0.0588063771637244 0.150249387080184 1023 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase NA K03856 Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG2876 E LFTS_01046 126.121285847292 0.401353504024759 0.213143663983119 1.88301869511142 0.0596978344436669 0.152248274676795 1932 Streptogramin lyase NA K01053 Carbohydrate metabolism; Xenobiotics biodegradation and metabolism; Overview Overview 01200 Carbon metabolism COG3386 G LFTS_00329 399.525166010843 -0.336381750048805 0.178648986369887 -1.88292000354447 0.0597112098993866 0.152248274676795 1005 alcohol dehydrogenase%2C propanol-preferring NA K13953 Amino acid metabolism; Carbohydrate metabolism; Metabolism of cofactors and vitamins; Xenobiotics biodegradation and metabolism; Lipid metabolism; Overview Overview 01220 Degradation of aromatic compounds COG1064 G LFTS_00335 5839.0144775037 -0.287424463544665 0.153035318503867 -1.87815771126978 0.0603595933387245 0.153743800245973 1740 proteasome-associated ATPase NA K13527 Folding, sorting and degradation Folding, sorting and degradation 03050 Proteasome COG0464 MDT LFTS_02049 81.4369013278114 0.507629163051045 0.270387493056771 1.87741362336039 0.0604614257448834 0.153845552100082 306 hypothetical protein NA NA NA NA NA NA NA LFTS_01371 371.373309590607 -0.327649867299278 0.174706954883951 -1.87542543751003 0.0607342183462231 0.15438166340359 501 hypothetical protein NA NA NA NA NA NA NA LFTS_00739 46.9409507931518 -0.564187795424576 0.301016952490481 -1.87427249780033 0.0608928761475258 0.154626854037537 2238 cellulose synthase (UDP-forming) Cellulose production K00694 Carbohydrate metabolism; Cellular community - prokaryotes Carbohydrate metabolism 00500 Starch and sucrose metabolism COG1215 N LFTS_01754 57.4322954054524 -0.594996560434026 0.317541131722984 -1.8737621712361 0.060963212518451 0.154647496245785 1500 Ni%2CFe-hydrogenase III large subunit NA K00333 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG0649 C LFTS_01320 559.142569394586 0.334223206552521 0.178718360243027 1.87011119673453 0.0614683779492673 0.155770017922404 870 hypothetical protein NA NA NA NA NA NA NA LFTS_02530 317.317229400106 0.355298418174174 0.190140040546087 1.8686144020678 0.0616764805964754 0.156138218699427 426 glyoxylase I family protein NA K08234 NA Overview 01200 Carbon metabolism COG0346 Q LFTS_00487 872.814293021424 -0.363358039054947 0.194537535498895 -1.86780426781449 0.06178935837582 0.156264847326845 1398 3-isopropylmalate dehydratase%2C large subunit NA K01702 Amino acid metabolism; Overview Overview 01210 2-Oxocarboxylic acid metabolism COG0065;COG0066 E LFTS_01494 26786.7851505403 0.242556104082821 0.130008858843953 1.86568904795908 0.0620848828347705 0.15685266130817 1239 40-residue YVTN family beta-propeller repeat-containing protein NA K01053 Carbohydrate metabolism; Xenobiotics biodegradation and metabolism; Overview Overview 01200 Carbon metabolism COG3386 G LFTS_00690 7163.51451215701 0.305580807886387 0.163873430025892 1.86473675346946 0.0622183123661084 0.157030177200148 1272 NADH-quinone oxidoreductase subunit D NADH dehydrogenase K00333 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG0649 C LFTS_01726 798.526479915459 -0.349657469161096 0.187885610239189 -1.8610124996585 0.0627424115399043 0.158082404813315 261 hypothetical protein NA K06400 NA Replication and repair 03030 DNA replication COG1961 L LFTS_00293 2182.74135538707 0.358388417629354 0.192627633699777 1.86052442604329 0.0628113659305534 0.158082404813315 1503 serine protease Do Oxidative stress response K04772 NA Replication and repair 03440 Homologous recombination COG0265 O LFTS_01521 752.393837288374 -0.305073825848643 0.163981073579509 -1.86042095706077 0.0628259919370698 0.158082404813315 1125 membrane fusion protein%2C Cu(I)/Ag(I) efflux system Copper/silver resistance; Cadmium/cobalt/zinc resistance K07798 Signal transduction Signal transduction 02020 Two-component system COG0845 MV LFTS_02076 1078.1688719153 -0.254552698675046 0.136888774525372 -1.85955860557336 0.0629480004323601 0.158105164277054 969 diguanylate cyclase (GGDEF) domain-containing protein Putative diguanylate cyclases (GGDEF domain-containing proteins) K13069 NA Signal transduction 02020 Two-component system COG2199 T LFTS_02443 2507.60597587436 -0.281109363485632 0.15117811153392 -1.85945809636973 0.0629622335616587 0.158105164277054 1542 L-aspartate oxidase NA K00278 Amino acid metabolism; Metabolism of cofactors and vitamins Amino acid metabolism 00250 Alanine, aspartate and glutamate metabolism COG0029 H LFTS_01155 162.065418405267 -0.568807152888119 0.305983458310679 -1.85894739548497 0.0630345951285875 0.158127147820049 432 MerR family transcriptional regulator%2C Zn(II)-responsive regulator of zntA NA K13638 NA Signal transduction 02020 Two-component system COG0789 K LFTS_00568 436.935887825857 -0.279937872800186 0.150838275621687 -1.85588088730403 0.0634705378029416 0.159060238889227 1557 PilZ domain-containing protein c-di-GMP effector proteins; Extracellular polysaccharide production and export K02481 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG2204 T LFTS_01773 137.822587913418 -0.433040414263756 0.233511203912219 -1.85447381970821 0.0636714022807251 0.159265128193837 363 DsrE/DsrF-like family protein NA K07092 NA Translation 03010 Ribosome COG2044 R LFTS_01686 1065.92936870601 0.277437673004834 0.149609616253878 1.8544106986682 0.06368042535184 0.159265128193837 231 small subunit ribosomal protein S18 NA K02963 Translation Translation 03010 Ribosome COG0238 J LFTS_02137 565.561467182194 0.302897498054635 0.163435117329572 1.85331954970138 0.0638365707069507 0.159495190731135 1956 basic amino acid/polyamine antiporter%2C APA family NA K03294 NA Translation 03010 Ribosome COG0531 E LFTS_00422 2358.27507875533 -0.376439017029855 0.203220213296527 -1.85236995337948 0.0639727168475578 0.159674873577338 471 transcriptional regulator%2C BadM/Rrf2 family NA K13643 NA Lipid metabolism 00564 Glycerophospholipid metabolism COG1959 K LFTS_02261 7048.97911544759 0.254380848671926 0.137425169648997 1.85104991554057 0.0641623724225682 0.15985451470637 309 DNA-binding protein HU-beta NA K03530 NA Overview 01230 Biosynthesis of amino acids COG0776 L LFTS_02528 260.684919890357 0.382987213469769 0.206939182894487 1.85072352230677 0.0642093382719216 0.15985451470637 1137 Putative MetA-pathway of phenol degradation NA NA NA NA NA NA NA LFTS_01655 3387.63586883766 0.313846884807001 0.169598629387869 1.85052724741802 0.0642375946064618 0.15985451470637 822 LSU ribosomal protein L2P NA K02886 Translation Translation 03010 Ribosome COG0090 J LFTS_00604 789.478058615357 0.295601130855908 0.160158306811216 1.84568091871964 0.0649385493942015 0.161294817472551 948 D-alanine--D-alanine ligase NA K01921 Metabolism of other amino acids; Glycan biosynthesis and metabolism; Drug resistance Metabolism of other amino acids 00473 D-Alanine metabolism COG1181 MR LFTS_00904 1434.46136134945 0.225394992890874 0.122123696254851 1.84562865195722 0.0649461433185936 0.161294817472551 942 Sugar or nucleoside kinase%2C ribokinase family NA K00852 Carbohydrate metabolism Carbohydrate metabolism 00030 Pentose phosphate pathway COG0524 G LFTS_01282 235.555234965631 -0.33081732977236 0.179509885307283 -1.84289199007659 0.0653447820197469 0.162122882336418 1014 hypothetical protein NA K07337 NA Amino acid metabolism 00270 Cysteine and methionine metabolism COG3417 M LFTS_02274 1188.85372341269 0.322981102837829 0.175307565977798 1.84236830302426 0.0654212949709889 0.162150886637964 207 LSU ribosomal protein L31P NA K02909 Translation Translation 03010 Ribosome COG0254 J LFTS_01471 50.9696544376385 0.53463545882007 0.290371153696942 1.84121408760205 0.0655901917039474 0.162407586231089 849 MoxR-like ATPase NA K03924 NA Nucleotide metabolism 00230 Purine metabolism COG0714 R LFTS_00281 494.030289033339 -0.33437989941965 0.18243431683252 -1.83287829409102 0.0668206723756254 0.165289742811746 936 Radical SAM superfamily protein NA K06871 NA Metabolism of cofactors and vitamins 00730 Thiamine metabolism COG0641 O LFTS_01213 100.455194706155 -0.429531873293657 0.234479724524119 -1.83185080998111 0.0669736508630933 0.165422106028045 276 addiction module antidote protein%2C HigA family NA K07729 NA Signal transduction 02020 Two-component system COG1476 K LFTS_02287 579.509308498571 0.399676737638093 0.21820878861617 1.83162529874599 0.0670072649920522 0.165422106028045 912 phosphate transport system permease protein NA K02038 Membrane transport Membrane transport 02010 ABC transporters COG0581 P LFTS_02312 156.908811013143 0.37809327037902 0.206589298347077 1.83016871350136 0.0672247145776918 0.165794286150934 1227 Major Facilitator Superfamily protein NA K05820 NA Signal transduction 02020 Two-component system COG0477 GEPR LFTS_00184 1747.26850727374 -0.249522377871134 0.136412190228179 -1.82917947035198 0.0673727268597096 0.165994647148898 705 peptidyl-prolyl cis-trans isomerase D NA K03770 NA Signal transduction 02020 Two-component system COG0760 O LFTS_01998 11962.6836256885 -0.205584294856604 0.112481153046171 -1.82772214979176 0.0675912621401746 0.166368195723242 1800 cell division protease FtsH NA K03798 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0465 O LFTS_01281 248.341375258915 -0.330518108875389 0.181083080106902 -1.82522910854105 0.0679664629105389 0.167101216042844 783 putative phosphoesterase NA K07096 NA Amino acid metabolism 00270 Cysteine and methionine metabolism COG2129 R LFTS_02471 937.949784208661 0.278683128947504 0.152715545216382 1.82485108868674 0.068023503875848 0.167101216042844 1068 Phosphotransferase enzyme family protein NA K07102 Carbohydrate metabolism Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG3178 R LFTS_01577 640.66954305695 0.267946633159794 0.146910106562398 1.82388155198831 0.0681699812289343 0.167295728859951 1239 diguanylate cyclase (GGDEF) domain-containing protein Putative diguanylate cyclases (GGDEF domain-containing proteins) K02488 Cell growth and death; Signal transduction Signal transduction 02020 Two-component system COG3706 TK LFTS_00271 154.072239146973 -0.474639581825447 0.260319152246495 -1.82329873821967 0.0682581573218278 0.167346922191385 264 hypothetical protein NA NA NA NA NA NA NA LFTS_00886 484.991878622987 -0.30535498509476 0.167552789833238 -1.82244047024626 0.0683881786234508 0.167500504490541 357 3-dehydroquinate synthase NA K01735 Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG0337 E LFTS_01342 1991.69871716725 -0.259582566982228 0.143605463733529 -1.80760926662166 0.0706673349736174 0.172912396401981 1053 methylthioribose-1-phosphate isomerase NA K08963 Amino acid metabolism Amino acid metabolism 00270 Cysteine and methionine metabolism NA LFTS_01278 96.6770137127487 0.431189550059034 0.238669256135508 1.80664052438417 0.0708183466422734 0.173111514014446 282 hypothetical protein NA NA NA NA NA NA NA LFTS_01520 745.222876691453 -0.350268642194224 0.194143122438698 -1.80417744288018 0.0712034943466125 0.173524186276924 3084 cobalt-zinc-cadmium resistance protein CzcA Cadmium/cobalt/zinc resistance K15726 NA Signal transduction 02020 Two-component system COG3696 P LFTS_02308 56.3785117843851 -0.544094169035158 0.301629416498348 -1.80384982125289 0.0712548531023231 0.173524186276924 951 PilZ domain-containing protein c-di-GMP effector proteins; Cellulose production K00694 Carbohydrate metabolism; Cellular community - prokaryotes Carbohydrate metabolism 00500 Starch and sucrose metabolism COG1215 N LFTS_01218 567.685168450512 -0.406226706785721 0.225249955224754 -1.80344855731664 0.0713177975698204 0.173524186276924 867 hypothetical protein NA NA NA NA NA NA NA LFTS_00984 150.44063706481 0.413353107176016 0.22920869485896 1.8033919150858 0.0713266864511642 0.173524186276924 1236 Apolipoprotein N-acyltransferase NA K03820 NA Drug resistance 01501 beta-Lactam resistance COG0815 M LFTS_02066 196.01038425301 -0.372965413629135 0.206820218909522 -1.80333149048786 0.0713361699014548 0.173524186276924 1728 DNA helicase/exodeoxyribonuclease V%2C alpha subunit NA K03581 Replication and repair Replication and repair 03440 Homologous recombination COG0507 L LFTS_00990 199.125967963014 -0.341013874903102 0.189652679255903 -1.79809679589584 0.0721616699127414 0.175350859091061 930 hypothetical protein NA NA NA NA NA NA NA LFTS_00143 1008.98743361014 -0.239593793982728 0.133279659476631 -1.79767711685021 0.0722281897462777 0.175350859091061 1212 HD domain-containing protein NA K07814 NA Folding, sorting and degradation 04122 Sulfur relay system COG3437 T LFTS_01718 584.011852454343 -0.262538787784558 0.146117957525369 -1.79675922269154 0.072373852528466 0.17553307062026 684 serine/threonine protein phosphatase 1 NA K07313 NA Metabolism of terpenoids and polyketides 00900 Terpenoid backbone biosynthesis COG0639 T LFTS_01048 68.4293691974712 0.480604705347292 0.267734330423392 1.7950806106459 0.0726408575065422 0.175993284573867 462 hypothetical protein NA NA NA NA NA NA NA LFTS_00760 709.936238423498 -0.2484413288223 0.138432342054406 -1.79467691679057 0.0727051903690111 0.175993284573867 1440 metallo-beta-lactamase family protein NA K07576 NA Energy metabolism 00190 Oxidative phosphorylation COG1236 J LFTS_00476 421.400285267968 -0.279151039129565 0.155781507276793 -1.791939518428 0.0731426548005533 0.176879999838692 678 hypothetical protein NA NA NA NA NA NA NA LFTS_02413 897.054438080503 0.350323237630083 0.196049083995635 1.78691596252437 0.0739510721549521 0.178661190842771 693 phospholipase/carboxylesterase NA K06130 Lipid metabolism Lipid metabolism 00564 Glycerophospholipid metabolism NA LFTS_02397 5191.03278744199 0.213767209247115 0.12000345940696 1.78134205716671 0.0748565877866156 0.180673278871385 255 4Fe-4S dicluster domain-containing protein NA K14120 NA Translation 03010 Ribosome COG1145 C LFTS_01970 497.46523814094 -0.370095319753337 0.207986617936119 -1.7794189040903 0.0751711094636526 0.181256428832823 207 hypothetical protein NA NA NA NA NA NA NA LFTS_00530 158.349693427764 -0.398025552897343 0.223868619437448 -1.77794258926298 0.075413284444108 0.181611761816602 1056 Glycosyltransferase involved in cell wall bisynthesis Extracellular polysaccharide production and export K07011 NA Metabolism of terpenoids and polyketides 00523 Polyketide sugar unit biosynthesis COG1216 G LFTS_01505 22553.2232327401 -0.450522245583008 0.253439776867518 -1.77763037496088 0.0754645816398027 0.181611761816602 207 cold shock protein (beta-ribbon%2C CspA family) NA K03704 NA Membrane transport 03070 Bacterial secretion system COG1278 K LFTS_00821 806.478865125402 -0.295778202023576 0.166468371244718 -1.77678317996375 0.0756039203364864 0.18177112761751 930 menaquinol-cytochrome c reductase iron-sulfur subunit Cytochrome b/c1 K03886 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG0723 C LFTS_01383 104.285005364753 -0.443002540467977 0.249633329766767 -1.77461295285319 0.0759618170226697 0.182455146974258 1119 ABC-2 type transport system permease protein NA K09686 NA NA NA NA LFTS_00802 1466.24281929058 0.276106671740136 0.155942647116905 1.77056550497791 0.076632982439519 0.183828633894643 504 ribosome maturation factor RimP NA K09748 NA Translation 03010 Ribosome COG0779 J LFTS_02148 593.023357479203 0.268159459586808 0.151479084012156 1.77027383902908 0.0766815339295029 0.183828633894643 1035 Methyltransferase domain-containing protein NA K00598 NA Overview 01200 Carbon metabolism COG0500 QR LFTS_00557 129.029792439121 -0.392381893122255 0.22175547524032 -1.76943497199798 0.0768213137690913 0.183986306387246 582 RNA polymerase sigma-70 factor%2C ECF subfamily NA K03088 NA Cellular community - prokaryotes 02026 Biofilm formation - Escherichia coli COG1595 K LFTS_00171 354.234208675129 0.295539171753001 0.167361053814084 1.76587781337292 0.077416350164444 0.18509893879238 855 Tetratricopeptide repeat-containing protein NA K09527 NA Metabolism of cofactors and vitamins 00130 Ubiquinone and other terpenoid-quinone biosynthesis NA LFTS_01199 43.9926837163316 -0.557605892878485 0.315786626340371 -1.76576791531846 0.0774347933805611 0.18509893879238 984 cyclic pyranopterin phosphate synthase NA K03639 Metabolism of cofactors and vitamins; Folding, sorting and degradation Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG2896 H LFTS_02429 1202.08833388607 0.242798650772324 0.137671471838371 1.76360902901783 0.0777978265195813 0.185702277963136 1260 glucose-1-phosphate adenylyltransferase NA K00975 Carbohydrate metabolism; Cellular community - prokaryotes Carbohydrate metabolism 00500 Starch and sucrose metabolism COG0448 G LFTS_00823 476.938807364882 0.288424801779891 0.163604238307958 1.76294211423165 0.0779102531232165 0.185702277963136 252 Glutaredoxin Oxidative stress response K03671 Cardiovascular diseases; Immune system Immune system 04621 NOD-like receptor signaling pathway COG0526 O LFTS_01838 85.4370728088354 -0.463093837375624 0.262683303099974 -1.76293594572083 0.0779112936104386 0.185702277963136 441 4-carboxymuconolactone decarboxylase NA K01607 Xenobiotics biodegradation and metabolism; Overview Overview 01220 Degradation of aromatic compounds COG0599 R LFTS_00127 3698.15943163981 -0.309638623235294 0.175775268900112 -1.76155966179322 0.0781437243979417 0.186077872464831 483 hypothetical protein NA K04542 Environmental adaptation; Nervous system; Signal transduction; Substance dependence; Cancers; Immune system Signal transduction 04014 Ras signaling pathway NA LFTS_00900 1749.28039940532 0.2365622629362 0.13436303614244 1.76062010600458 0.0783027232739977 0.186278057472879 825 tol-pal system protein YbgF NA K05807 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG4105 M LFTS_01787 159.076132114286 0.468760248978471 0.26632931398471 1.76007755948856 0.0783946570500354 0.186318467902857 240 hypothetical protein NA NA NA NA NA NA NA LFTS_01597 1715.60304448738 -0.292605591179035 0.166479168247109 -1.75761084260533 0.078813747205408 0.187135602247034 1806 PAS domain S-box-containing protein NA K00936 NA Cellular community - prokaryotes 02024 Quorum sensing NA LFTS_01357 1102.02277091467 0.225801239440901 0.128665317322666 1.75495031714442 0.0792678063429616 0.188034128405155 1239 aspartate kinase NA K00928 Amino acid metabolism; Overview; Biosynthesis of other secondary metabolites Overview 01210 2-Oxocarboxylic acid metabolism COG0527 E LFTS_01613 266.254235388623 0.31166433171084 0.17779269938835 1.75296473242738 0.0796080609585059 0.188437836943544 858 ABC-2 type transport system permease protein NA K09686 NA NA NA NA LFTS_00937 1996.59783162605 -0.21569175540477 0.123073101675965 -1.75254992738103 0.0796792926749892 0.188437836943544 909 FdhE protein NA K02380 NA Replication and repair 03410 Base excision repair COG3058 CO LFTS_02478 4831.92493186516 -0.23478697502746 0.133990408666145 -1.75226702690685 0.0797279030056478 0.188437836943544 948 TPR repeat-containing protein NA K03350 Cell growth and death; Endocrine system; Folding, sorting and degradation; Infectious diseases Folding, sorting and degradation 04120 Ubiquitin mediated proteolysis NA LFTS_00130 936.316549582981 0.247192585425417 0.141076382332111 1.75218970985161 0.0797411924636396 0.188437836943544 1215 hypothetical protein NA NA NA NA NA NA NA LFTS_02411 199.852989571665 0.362095949692309 0.207339659206735 1.74639020377317 0.0807431710312707 0.190624428474586 534 peptide deformylase NA K01462 NA Metabolism of cofactors and vitamins 00670 One carbon pool by folate COG0242 J LFTS_01007 273.86230902081 0.326567680924962 0.187461720663447 1.74204994902002 0.0814997044722976 0.192227955709803 543 hypothetical protein NA K07038 NA Cellular community - prokaryotes 02024 Quorum sensing COG1988 R LFTS_01645 976.471903630316 0.277558283646416 0.159853377575401 1.73633042889879 0.08250542583463 0.194253445789448 288 ribosomal protein L15 NA K02876 Translation Translation 03010 Ribosome COG0200 J LFTS_00621 7831.27759144087 0.312415945557297 0.179934315341857 1.73627773537103 0.082514738034456 0.194253445789448 909 4-hydroxy-3-methylbut-2-enyl diphosphate reductase NA K03527 Metabolism of terpenoids and polyketides Metabolism of terpenoids and polyketides 00900 Terpenoid backbone biosynthesis COG0761 I LFTS_01551 7505.58853612433 -0.21712256179547 0.125326329099806 -1.73245768351326 0.0831921052009852 0.195335824539328 4578 glutamate synthase (NADPH/NADH) large chain NA K00265 Energy metabolism; Amino acid metabolism; Overview Overview 01230 Biosynthesis of amino acids COG0067;COG0069;COG0070 E LFTS_00620 5918.87786928212 0.187118897804707 0.108027993964505 1.73213341225412 0.0832498114291755 0.195335824539328 1011 dihydroflavonol-4-reductase NA K00091 NA Signal transduction 02020 Two-component system COG0451 M LFTS_02267 425.015961428781 0.315643100298541 0.182240542191359 1.73201361509946 0.0832711383306278 0.195335824539328 633 imidazoleglycerol-phosphate dehydratase NA K01693 Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG0131 E LFTS_00769 1395.77769418707 0.240821527174639 0.1390493254738 1.73191438616518 0.0832888069234465 0.195335824539328 1404 phosphomannomutase / phosphoglucomutase Extracellular polysaccharide production and export K15778 Carbohydrate metabolism; Biosynthesis of other secondary metabolites; Nucleotide metabolism Carbohydrate metabolism 00010 Glycolysis / Gluconeogenesis COG1109 G LFTS_00806 405.559801639624 0.305997232749717 0.176874763560659 1.73002200308116 0.0836263441160812 0.195942593282354 396 ribosome-binding factor A NA K02834 NA Translation 03010 Ribosome COG0858 J LFTS_00408 1614.24405346677 0.28552584594089 0.165280593082667 1.7275219105614 0.0840739736441363 0.19680593077149 1218 Transposase (or an inactivated derivative) NA K07493 NA Lipid metabolism 00564 Glycerophospholipid metabolism COG3328 X LFTS_01322 340.174375273161 -0.348615144841285 0.202346649645307 -1.72286096879969 0.084913670118056 0.198584556833008 888 NTE family protein NA K07001 NA Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG1752 R LFTS_02357 907.215888416808 0.228856594731897 0.133014073904772 1.72054421019945 0.085333564629272 0.199378986530423 930 ornithine carbamoyltransferase NA K00611 Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG0078 E LFTS_01457 211.789885642735 -0.357105746555085 0.207734113740867 -1.71905201377059 0.0856049013286484 0.199825149955887 423 hypothetical protein NA NA NA NA NA NA NA LFTS_00057 140.854708066516 0.378369462550124 0.220355677173078 1.71708515707056 0.0859636137789841 0.200474243765998 975 peptide/nickel transport system permease protein NA K02033 Cellular community - prokaryotes Cellular community - prokaryotes 02024 Quorum sensing COG0601 EP LFTS_00910 21.1714041065203 -0.683229285959271 0.39833537357163 -1.71521117954746 0.0863065159301289 0.201085284538239 303 hypothetical protein NA K07733 NA Membrane transport 02010 ABC transporters COG3311 KX LFTS_00088 420.35243246221 -0.28939586162225 0.169029695718977 -1.71210070746024 0.0868781110291556 0.202227513125918 852 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase NA K14153 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00730 Thiamine metabolism COG0351;COG0352 H LFTS_02209 463.348201996636 -0.26730172953249 0.156365350683679 -1.70946906308694 0.0873640975595628 0.203168518740012 471 putative nucleic acid-binding protein%2C contains PIN domain NA K07064 NA Overview 01220 Degradation of aromatic compounds COG1848 R LFTS_01634 703.432427905957 0.313071332757828 0.183284904092211 1.70811302932139 0.087615371752166 0.203562443155032 858 trehalose 6-phosphate phosphatase Lipopolysaccharide synthesis K01087 Carbohydrate metabolism Carbohydrate metabolism 00500 Starch and sucrose metabolism COG1877 G LFTS_01980 2213.11077339497 -0.254475025722322 0.149170262201266 -1.70593670592987 0.0880198646951532 0.204205561854052 1437 proteasome accessory factor A NA K13571 NA Folding, sorting and degradation 03050 Proteasome NA LFTS_01118 100.551617357348 0.444215789284969 0.260424060381567 1.70574020170838 0.0880564611052068 0.204205561854052 1239 Type II secretory pathway%2C component PulF NA K02653 NA Replication and repair 03030 DNA replication COG1459 NUW LFTS_01905 403.888143605049 0.260243057811617 0.152724890828621 1.70399897750554 0.088381278265107 0.204767807797815 1122 hypothetical protein NA NA NA NA NA NA NA LFTS_02364 869.369772889945 -0.280994081172695 0.16500847852495 -1.70290692747771 0.0885854874183196 0.205049834005533 513 chorismate lyase NA NA NA NA NA NA NA LFTS_01254 46.3330871811319 -0.514168316136859 0.3024158633729 -1.70020286106107 0.0890927743049525 0.205867002495198 165 hypothetical protein NA NA NA NA NA NA NA LFTS_00938 678.792743340878 -0.237717000677736 0.139821816575859 -1.70014241338915 0.089104141063891 0.205867002495198 252 hypothetical protein NA K06575 Immune system; Infectious diseases Immune system 04640 Hematopoietic cell lineage NA LFTS_01224 218.541220056593 0.379542617523539 0.223390647544191 1.69900853816388 0.0893175748815789 0.206045641068135 1125 histidinol-phosphate aminotransferase NA K00817 Overview; Amino acid metabolism; Biosynthesis of other secondary metabolites Overview 01230 Biosynthesis of amino acids COG0079 E LFTS_01506 302.336661990634 -0.350298221540255 0.206197118830257 -1.69885119407815 0.0893472248879525 0.206045641068135 603 general secretion pathway protein H NA K02457 Cellular community - prokaryotes; Membrane transport Membrane transport 03070 Bacterial secretion system COG2165 NUW LFTS_02365 3068.270429117 -0.216791757879603 0.127827308050699 -1.69597374133561 0.089890853041005 0.207107192455921 1593 hypothetical protein NA K04034 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG1032 R LFTS_02489 1101.03235825532 -0.272932638128115 0.161151911798872 -1.69363574456847 0.0903345213692054 0.20786076275516 486 hypothetical protein NA NA NA NA NA NA NA LFTS_01595 2563.22038421939 -0.214758318455979 0.126900399447794 -1.69233760800201 0.0905816210793748 0.20786076275516 2625 PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein Genes encoding proteins with EAL and GGDEF domains K14051 Cellular community - prokaryotes Cellular community - prokaryotes 02024 Quorum sensing COG2199;COG2200;COG2202 T LFTS_01995 407.728548349613 -0.289307221766794 0.170972025971751 -1.69213191527949 0.0906208244537203 0.20786076275516 960 riboflavin kinase / FMN adenylyltransferase NA K11753 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00740 Riboflavin metabolism COG0196 H LFTS_01183 10.7111077911727 0.720601333878736 0.426013523998011 1.69149872782466 0.0907415905580488 0.20786076275516 357 nitrogenase-stabilizing/protective protein Nitrogenase genes K02595 NA Signal transduction 02020 Two-component system NA LFTS_00737 55.1729547609105 -0.571474555104093 0.337867234859243 -1.69141750410386 0.0907570914985786 0.20786076275516 2892 Tetratricopeptide repeat protein NA K05838 NA Energy metabolism 00190 Oxidative phosphorylation COG3118 O LFTS_01734 224.788824400021 0.34844109726415 0.206013105577182 1.69135403443354 0.0907692056934691 0.20786076275516 1002 Cache domain-containing protein NA K10937 Cellular community - prokaryotes Cellular community - prokaryotes 05111 Biofilm formation - Vibrio cholerae NA LFTS_00783 658.178190803711 0.279547463458578 0.165297686801636 1.69117589524436 0.0908032133355204 0.20786076275516 714 Vitamin B12 dependent methionine synthase%2C activation domain NA K00548 Amino acid metabolism; Overview; Metabolism of cofactors and vitamins; Metabolism of other amino acids Overview 01230 Biosynthesis of amino acids COG0646;COG1410 E LFTS_02248 1897.60673807923 0.220382405503517 0.130539228653644 1.688246573666 0.0913639062772275 0.208809798217387 1932 ATP-binding cassette%2C subfamily F%2C member 3 NA K06158 NA Folding, sorting and degradation 04141 Protein processing in endoplasmic reticulum COG0488 R LFTS_01510 770.081957156817 -0.253371735825628 0.150089952146376 -1.68813256452055 0.0913857845778429 0.208809798217387 1314 ATP phosphoribosyltransferase regulatory subunit NA K02502 Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG3705 E LFTS_01432 196.153813526601 -0.369972643514057 0.219671998917564 -1.68420483874641 0.0921420884486093 0.210344565549351 462 Transposase NA K07488 NA Nucleotide metabolism 00230 Purine metabolism COG3676 X LFTS_00453 430.403069827633 0.390578357960236 0.232111078422547 1.6827217408779 0.092428970977489 0.210805891605539 1704 K+-transporting ATPase ATPase A chain Role of potassium in the internal positive membrane potential K01546 Signal transduction Signal transduction 02020 Two-component system COG2060 P LFTS_01789 25.7202083404947 0.614332119632508 0.365561824376472 1.68051497357624 0.0928571634654762 0.211588366979994 762 DNA replication protein DnaC NA K02315 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG1484 L LFTS_01828 981.427208947936 -0.331779974356584 0.197524469832354 -1.67969049423688 0.0930175502311945 0.211759734317536 1668 NAD(P)H-quinone oxidoreductase subunit 5 NADH dehydrogenase K05577 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG1009 CP LFTS_02190 520.384389466953 -0.301678415157821 0.179694886276822 -1.6788369519491 0.0931838248021892 0.211944179742216 627 chromosome partitioning protein NA K03496 NA Carbohydrate metabolism 00630 Glyoxylate and dicarboxylate metabolism COG1192 N LFTS_00431 11.5255573645472 0.707798168444555 0.421763609512398 1.67818690963604 0.0933106164265935 0.21203856712661 195 helix-turn-helix protein NA K07108 NA Overview 01210 2-Oxocarboxylic acid metabolism COG2522 R LFTS_01298 385.440989183686 0.380403433596742 0.226750007774514 1.6776336077352 0.0934186477306806 0.212065874356448 1074 Glycosyl transferase family 2 Lipopolysaccharide synthesis K07011 NA Membrane transport 02010 ABC transporters COG1216 G LFTS_01618 1450.45977008974 0.211536080033641 0.126120641053733 1.67725186191781 0.0934932414700995 0.212065874356448 933 LysR family transcriptional regulator%2C nitrogen assimilation regulatory protein Nitrate/nitrite regulation K11921 NA Nucleotide metabolism 00230 Purine metabolism COG0583 K LFTS_01332 1368.19378720713 0.261207685921553 0.156208668377197 1.67217151669723 0.0944905054030129 0.214132540047302 1569 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase NA K00602 Metabolism of cofactors and vitamins; Nucleotide metabolism; Drug resistance Nucleotide metabolism 00230 Purine metabolism COG0138 F LFTS_01327 130.334635536363 -0.358053624951031 0.214732972255437 -1.6674366362568 0.0954276140673797 0.216059242779149 552 undecaprenyl-diphosphatase NA K01096 Lipid metabolism Lipid metabolism 00564 Glycerophospholipid metabolism COG0671 I LFTS_02384 347.472802442741 0.288769748555317 0.173246288572169 1.66681636262023 0.0955509256104184 0.216141584228845 774 phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein NA K02065 Membrane transport Membrane transport 02010 ABC transporters COG1127 M LFTS_01738 73.1644837560829 -0.457068524887696 0.274514937789578 -1.66500420184074 0.0959119175280008 0.216760933613282 495 methylated-DNA-[protein]-cysteine S-methyltransferase NA K00567 NA Carbohydrate metabolism 00500 Starch and sucrose metabolism COG0350 L LFTS_01972 14215.488498305 0.215685260502768 0.129756145503984 1.66223541601846 0.0964655814974755 0.217814201274046 531 cytochrome c oxidase cbb3-type subunit 2 Cytochrome cbb3 oxidase K00405 Energy metabolism; Signal transduction Energy metabolism 00190 Oxidative phosphorylation COG2993 C LFTS_00044 1090.58974561413 0.229701404179916 0.138340495604388 1.66040611012984 0.0968327817813747 0.218392305418447 732 outer membrane protein assembly factor BamD NA K05807 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG4105 M LFTS_01238 137.792005187513 -0.394201935523012 0.237458855187908 -1.66008521859953 0.0968973100871066 0.218392305418447 177 hypothetical protein NA K15152 NA Biosynthesis of other secondary metabolites 00405 Phenazine biosynthesis NA LFTS_00582 1034.07509619871 0.305786691151712 0.184316634988889 1.65902926325747 0.0971098956985362 0.218555946471908 810 citryl-CoA lyase Reductive TCA cycle carbon dioxide fixation K15234 Overview; Energy metabolism Overview 01200 Carbon metabolism NA LFTS_01758 104.694528293895 0.439938751503209 0.265206851892525 1.65885137719403 0.0971457445098383 0.218555946471908 306 putative ATP-dependent DNA helicase MPH1 NA K04560 Substance dependence; Folding, sorting and degradation; Nervous system; Endocrine system Folding, sorting and degradation 04130 SNARE interactions in vesicular transport NA LFTS_02206 1216.75367584972 -0.242134686638748 0.146040974824265 -1.65799144336112 0.097319193467173 0.218748205207407 906 hypothetical protein NA NA NA NA NA NA NA LFTS_01523 681.661803332727 0.23983895547891 0.14481268521935 1.65620128592756 0.0976810629297973 0.219243225812546 1194 hypothetical protein NA NA NA NA NA NA NA LFTS_01884 926.680075372002 -0.225646464598806 0.136257499378528 -1.65602969104807 0.0977158061948115 0.219243225812546 2055 Glucoamylase (glucan-1%2C4-alpha-glucosidase)%2C GH15 family NA K01178 Carbohydrate metabolism Carbohydrate metabolism 00500 Starch and sucrose metabolism COG3387 G LFTS_02523 323.545155287394 0.293394817303588 0.177571455542863 1.65226340239558 0.0984808664745371 0.220760535667898 852 hypothetical protein NA K09719 NA Membrane transport 02010 ABC transporters COG1689 S LFTS_00624 85.6328406794274 0.42960491770687 0.260198139918351 1.65106836598324 0.0987246158598703 0.221107563087962 294 EamA-like transporter family protein NA K12962 Drug resistance Drug resistance 01503 Cationic antimicrobial peptide (CAMP) resistance COG0697 GER LFTS_02006 168.227693332478 -0.32438986152247 0.196724033191072 -1.64895898208533 0.0991560382340721 0.221873907335647 1695 monovalent cation:H+ antiporter%2C CPA1 family Proton transporters K03316 NA Membrane transport 02060 Phosphotransferase system (PTS) COG0025 P LFTS_01180 4.0389673955165 -0.683679490502189 0.414894863962902 -1.64783792205082 0.0993859349127715 0.222188340101754 261 hypothetical protein NA NA NA NA NA NA NA LFTS_01946 555.739875238121 0.253937215267488 0.154246630513004 1.64630640178606 0.0997006921353302 0.222691752604161 801 Zinc carboxypeptidase NA K06987 NA Energy metabolism 00190 Oxidative phosphorylation COG3608 R LFTS_01215 856.680084511903 -0.318872911121982 0.193883541176727 -1.64466209553768 0.100039513653672 0.223247963144549 1980 PAS domain S-box-containing protein Quorum sensing K07710 Signal transduction Signal transduction 02020 Two-component system COG0642 T LFTS_02034 92.3366323881226 0.40352879264537 0.246289930142435 1.63842992854803 0.101332040164907 0.225929553228662 3456 conjugative relaxase domain-containing protein%2C TrwC/TraI family NA K03581 Replication and repair Replication and repair 03440 Homologous recombination COG0507 L LFTS_01632 1846.06920014139 0.247047082301008 0.151114812145773 1.63483035708435 0.102084615060627 0.227131268313594 1086 Glycosyltransferase involved in cell wall bisynthesis Lipopolysaccharide synthesis K03867 NA Carbohydrate metabolism 00500 Starch and sucrose metabolism COG0438 M LFTS_01997 598.24625487431 0.255360796890859 0.156231151116208 1.63450627526207 0.10215258968228 0.227131268313594 531 hypoxanthine phosphoribosyltransferase NA K00760 Xenobiotics biodegradation and metabolism; Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0634 F LFTS_01890 274.963557721671 0.277846669559101 0.170021529565004 1.63418521330778 0.10221996641572 0.227131268313594 444 HSP20 family protein NA K13993 Folding, sorting and degradation Folding, sorting and degradation 04141 Protein processing in endoplasmic reticulum COG0071 O LFTS_01331 384.33229565366 0.261637241459178 0.160110270427125 1.63410654895036 0.102236479985081 0.227131268313594 1515 Dolichyl-phosphate-mannose-protein mannosyltransferase Lipopolysaccharide synthesis K07264 Drug resistance Drug resistance 01503 Cationic antimicrobial peptide (CAMP) resistance COG1807 M LFTS_00815 404.155445936321 0.259844058369708 0.159230648752352 1.63187213269374 0.102706425701312 0.227971584190591 792 DNA polymerase NA K02334 NA Folding, sorting and degradation 03018 RNA degradation COG1573 L LFTS_01627 1671.07844041737 -0.201423763091621 0.123474899255498 -1.6312931964806 0.102828468278733 0.228038868992801 1515 amidophosphoribosyltransferase NA K00764 Amino acid metabolism; Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0034 F LFTS_01406 890.419788083701 0.218774175621257 0.134160893422087 1.63068514259939 0.10295677316246 0.228119909163882 3528 putative protein YhaN NA K03546 NA Transport and catabolism 04144 Endocytosis COG0419 L LFTS_01132 125.089478308084 0.366217164975198 0.224656847543788 1.63011797316269 0.103076565789377 0.228127982488163 1980 type IV secretion system protein VirD4 NA K03205 Membrane transport Membrane transport 03070 Bacterial secretion system COG3505 U LFTS_01028 1439.3456317956 0.233988669947447 0.143569019254816 1.6297991806446 0.103143947030046 0.228127982488163 1167 transposase%2C IS605 OrfB family%2C central region NA K07496 NA Metabolism of other amino acids 00410 beta-Alanine metabolism COG0675 X LFTS_01572 146.326966164197 0.34602494185891 0.212632931664848 1.62733467083224 0.10366603816324 0.22907890744339 204 zinc-binding protein NA K09862 NA Metabolism of cofactors and vitamins 00780 Biotin metabolism COG3024 L LFTS_00261 156.966670197409 -0.348789766046246 0.214415278970684 -1.62670201359081 0.103800400898824 0.229172110687812 474 dUTP pyrophosphatase NA K01520 Nucleotide metabolism Nucleotide metabolism 00240 Pyrimidine metabolism COG0756 FV LFTS_02181 792.420669401076 0.266096623517453 0.163656330326863 1.62594763664803 0.10396079511486 0.229322570235618 744 hypothetical protein NA NA NA NA NA NA NA LFTS_00264 329.886513690536 0.283431273137858 0.174421507586177 1.62497892066334 0.104167050419408 0.229522528418325 822 putative amidohydrolase NA K08590 Amino acid metabolism Amino acid metabolism 00250 Alanine, aspartate and glutamate metabolism COG0388 R LFTS_00800 686.528142025084 0.263823023871524 0.162408437776953 1.62444160834704 0.104281592980364 0.229522528418325 603 hypothetical protein NA K16211 NA Translation 03010 Ribosome COG0477 GEPR LFTS_02160 2751.32673430174 0.246052861421407 0.15148966744664 1.62422207117245 0.104328422008329 0.229522528418325 756 3-oxoacyl-[acyl-carrier-protein] reductase NA K00059 Lipid metabolism; Overview; Metabolism of cofactors and vitamins Overview 01212 Fatty acid metabolism COG1028 IQR LFTS_02288 616.478202917894 0.362981957599838 0.223819887389049 1.62175918250238 0.104854921290994 0.230476865012742 1023 phosphate ABC transporter membrane protein 1%2C PhoT family NA K02037 Membrane transport Membrane transport 02010 ABC transporters COG0573 P LFTS_00893 102.441832388472 0.396297079306742 0.244474637983075 1.62101509823763 0.105014400704178 0.230623498366243 522 DDE superfamily endonuclease NA NA NA NA NA NA NA LFTS_02469 915.73018537877 -0.21473424329648 0.132541734631474 -1.6201254940079 0.10520532201096 0.230838861888126 1269 anhydro-N-acetylmuramic acid kinase NA K09001 NA Nucleotide metabolism 00230 Purine metabolism COG2377 M LFTS_01394 869.657767084502 0.247458579379476 0.152842944527156 1.61903828891172 0.105439025115553 0.231147633542561 1644 phosphoglucomutase Extracellular polysaccharide production and export K01835 Carbohydrate metabolism; Nucleotide metabolism; Biosynthesis of other secondary metabolites Carbohydrate metabolism 00010 Glycolysis / Gluconeogenesis COG0033 G LFTS_02014 221.956032307176 -0.333972348580646 0.206379375767793 -1.61824478506231 0.105609854766786 0.231318148854828 1584 deoxyribodipyrimidine photo-lyase NA K01669 NA Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG0415 L LFTS_02432 2186.52467175501 -0.195881365931369 0.121085254116489 -1.61771445549367 0.105724149247444 0.231364643511571 663 putative O-methyltransferase YrrM NA K00588 Biosynthesis of other secondary metabolites; Amino acid metabolism Amino acid metabolism 00360 Phenylalanine metabolism COG4122 R LFTS_01376 217.205485892813 -0.334426141262888 0.207117657456437 -1.61466745698989 0.106382728558144 0.232554905326607 927 beta-aspartyl-peptidase (threonine type) NA K13051 NA Folding, sorting and degradation 04130 SNARE interactions in vesicular transport COG1446 E LFTS_02004 36.4977460136933 0.530657209826739 0.328716006778175 1.6143333421084 0.106455141698181 0.232554905326607 567 Nicotinamidase-related amidase NA K09020 Nucleotide metabolism Nucleotide metabolism 00240 Pyrimidine metabolism COG1335 HR LFTS_00531 185.78242292322 -0.370230860733315 0.229787090079811 -1.61119086631335 0.107138127957818 0.23384142765859 1104 Glycosyltransferase involved in cell wall bisynthesis Extracellular polysaccharide production and export K07011 NA Metabolism of terpenoids and polyketides 00523 Polyketide sugar unit biosynthesis COG1216 G LFTS_00623 1257.93280588854 -0.206511310089989 0.128232662745141 -1.61044234494628 0.10730132255983 0.233992182354156 1239 ceramide glucosyltransferase NA K00720 Lipid metabolism Lipid metabolism 00600 Sphingolipid metabolism COG1215 N LFTS_00392 290.642761777876 0.291542983578599 0.181157534219508 1.60933402430471 0.107543323100048 0.234314374431831 1221 sodium/proton antiporter%2C CPA1 family Proton transporters K03316 NA Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG0025 P LFTS_00539 105.196349871597 0.388031034033763 0.24126511054479 1.60831805791383 0.10776553771483 0.234462699665583 837 putative PEP-CTERM system histidine kinase Extracellular polysaccharide production and export NA NA NA NA NA NA LFTS_01041 145.198527683019 0.364823418293176 0.226881640564018 1.60799004003251 0.107837360161506 0.234462699665583 2193 ribonucleoside-diphosphate reductase class II NA K00525 Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0209 F LFTS_02191 235.635882333597 -0.36921679199068 0.229651003078792 -1.6077299338597 0.107894339669118 0.234462699665583 270 hypothetical protein NA NA NA NA NA NA NA LFTS_01464 8.81760355847044 -0.694338849883897 0.432719451667264 -1.60459357028813 0.10858327734946 0.235607593248804 294 hypothetical protein NA K12068 NA Membrane transport 03070 Bacterial secretion system NA LFTS_02015 325.175924707594 -0.287598142101554 0.179248190745112 -1.60446887026332 0.108610740894259 0.235607593248804 1266 voltage-gated potassium channel Role of potassium in the internal positive membrane potential; Proton transporters K10716 NA Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG1226 P LFTS_01454 1243.66747533154 0.243661102181193 0.151910163488823 1.60398156769228 0.10871811559704 0.235634904423926 819 Prolipoprotein diacylglyceryl transferase NA K13292 NA Signal transduction 02020 Two-component system COG0682 M LFTS_02457 8481.37188366572 0.3296302158395 0.20559584212296 1.60329222826578 0.108870151517895 0.235741109128688 867 pyruvate ferredoxin oxidoreductase beta subunit Reductive TCA cycle carbon dioxide fixation K00170 Carbohydrate metabolism; Overview; Energy metabolism; Xenobiotics biodegradation and metabolism Overview 01200 Carbon metabolism COG1013 C LFTS_01227 166.590353668556 -0.39433649886228 0.24602892420689 -1.60280544303269 0.108977614765257 0.235741109128688 846 Glyoxylase%2C beta-lactamase superfamily II NA K05555 Metabolism of terpenoids and polyketides Metabolism of terpenoids and polyketides 01057 Biosynthesis of type II polyketide products COG0491 R LFTS_02292 65.0940246787861 0.481578393629439 0.300522464841231 1.602470530394 0.109051599154461 0.235741109128688 780 two-component system%2C OmpR family%2C alkaline phosphatase synthesis response regulator PhoP NA K07658 Signal transduction Signal transduction 02020 Two-component system COG0745 TK LFTS_01671 909.636354931763 0.377894041337306 0.235963985731587 1.60149032983011 0.109268360133761 0.235848392905033 210 preprotein translocase subunit SecE NA K03073 Cellular community - prokaryotes; Folding, sorting and degradation; Membrane transport Folding, sorting and degradation 03060 Protein export COG0690 U LFTS_02527 194.984529466275 0.413867609775301 0.258499613117964 1.60103763709092 0.109368583274127 0.235848392905033 570 TPR repeat-containing protein NA K12284 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism NA LFTS_01990 3085.06581328564 -0.231391585818831 0.144570824663791 -1.60054137034181 0.109478536903808 0.235848392905033 810 ABC-type uncharacterized transport system%2C permease component NA K02497 NA Nucleotide metabolism 00230 Purine metabolism COG0755 O LFTS_01745 97.7204758919378 -0.38577163478077 0.241032481875242 -1.60049646329595 0.109488490888592 0.235848392905033 1044 hypothetical protein NA NA NA NA NA NA NA LFTS_01409 101.113032835818 0.389410898006188 0.243366038399742 1.60010369798007 0.109575580774462 0.235848392905033 717 Outer membrane protein OmpA NA K02557 Cell motility Cell motility 02030 Bacterial chemotaxis COG1360 N LFTS_01060 57.4323570821351 -0.454880218884767 0.284432091954914 -1.59925772003558 0.10976334983332 0.236048172738437 672 HD domain-containing protein NA K07814 NA Translation 03010 Ribosome COG3437 T LFTS_01208 38.3086356591029 -0.513079892483192 0.321017574120333 -1.59829222399788 0.109977957166327 0.236227235694613 258 hypothetical protein NA NA NA NA NA NA NA LFTS_00999 270.181100871553 -0.412543303728987 0.258157682624127 -1.59802838147429 0.110036660874643 0.236227235694613 156 hypothetical protein NA K12415 Cellular community - prokaryotes; Signal transduction Signal transduction 02020 Two-component system NA LFTS_01308 764.30796306029 0.255462114915855 0.159926987793802 1.59736713884231 0.110183893003589 0.236339221748854 993 Glycosyltransferase%2C GT2 family Lipopolysaccharide synthesis K07011 NA Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG1216 G LFTS_01035 1074.29220966867 0.23215583978249 0.145936643572265 1.59079881584046 0.111654859547205 0.238918655742143 2952 hypothetical protein NA K00558 Amino acid metabolism; Cancers Amino acid metabolism 00270 Cysteine and methionine metabolism COG0270 L LFTS_00695 1962.87445755068 0.245296571324797 0.154198527071134 1.59078414031567 0.111658163372608 0.238918655742143 561 NADH-quinone oxidoreductase subunit I NADH dehydrogenase K00338 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG1143 C LFTS_01835 143.592385194705 -0.372195886356062 0.233980925200509 -1.59071037964787 0.11167476990039 0.238918655742143 834 Pimeloyl-ACP methyl ester carboxylesterase NA K06889 NA Amino acid metabolism 00280 Valine, leucine and isoleucine degradation COG1073 T LFTS_01107 208.865643949113 0.305082915599691 0.192901861722703 1.58154469259736 0.113753548513274 0.243156768361133 1164 hypothetical protein NA K06871 NA Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG0641 O LFTS_01712 247.748064623945 0.678438913749383 0.430133990209301 1.57727342919182 0.114732623499769 0.245038919261534 456 hypothetical protein NA K07010 NA Signal transduction 02020 Two-component system COG2071 E LFTS_00805 362.050451800723 -0.353681006088926 0.224388574574383 -1.57619881832122 0.114979990783557 0.245356443852295 300 hypothetical protein NA K09764 NA Translation 03010 Ribosome COG1550 S LFTS_01439 536.418712466383 0.277518915042465 0.176411318768032 1.57313553903751 0.11568743738135 0.246581513270082 732 Zn-dependent protease (includes SpoIVFB) NA K06402 NA Metabolism of cofactors and vitamins 00130 Ubiquinone and other terpenoid-quinone biosynthesis COG1994 O LFTS_00371 241.447504496911 0.335825116650625 0.213513120202845 1.57285470949785 0.11575246419396 0.246581513270082 492 hypothetical protein NA NA NA NA NA NA NA LFTS_00691 4789.57776824399 0.195460546853822 0.124460979405687 1.57045644174716 0.116308960404182 0.247554859216435 507 NADH-quinone oxidoreductase subunit E NADH dehydrogenase K00334 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG1905 C LFTS_02108 930.895385588142 -0.237851296295735 0.151718977117706 -1.56770959582206 0.116948921216142 0.248704036050751 669 putative membrane protein NA K10110 Membrane transport Membrane transport 02010 ABC transporters COG3833 G LFTS_01197 27.4668497743217 -0.584957685794645 0.373491036203052 -1.56618935688895 0.117304293615206 0.24924655891231 453 molybdopterin synthase catalytic subunit NA K03635 Metabolism of cofactors and vitamins; Folding, sorting and degradation Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG0314 H LFTS_02515 1534.13160755178 -0.214610159794548 0.13707334510881 -1.56565931636226 0.117428395467684 0.249297174323367 555 peptide deformylase NA K01462 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0242 J LFTS_01977 597.167333326499 -0.311384467829444 0.199035824139156 -1.56446443335617 0.117708539242882 0.249678693308707 339 (2Fe-2S) ferredoxin NA K05587 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG1894 C LFTS_01401 565.731752042197 -0.225476755042742 0.144347284020005 -1.56204362675431 0.118277711707136 0.250672115348628 288 hypothetical protein NA K06400 NA Transport and catabolism 04144 Endocytosis COG1961 L LFTS_01413 133.876845357998 -0.360046267320381 0.231475958500255 -1.55543698642892 0.119842031087826 0.253623562054912 588 LPP20 lipoprotein NA NA NA NA NA NA NA LFTS_01626 959.766064173242 -0.233909572873833 0.150395039131747 -1.555301120464 0.1198743706414 0.253623562054912 2214 phosphoribosylformylglycinamidine synthase subunit II NA K01952 Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0046;COG0047 F LFTS_00717 175.253575342789 -0.323547126751938 0.208289787516663 -1.55335088968802 0.120339328696731 0.254181851007389 1041 general secretion pathway protein K NA K02460 Cellular community - prokaryotes; Membrane transport Membrane transport 03070 Bacterial secretion system COG3156 U LFTS_01962 2921.2437857239 -0.189214133509226 0.121811415805303 -1.55333662496507 0.120342734768985 0.254181851007389 1329 Polyferredoxin NA K02574 NA Overview 01200 Carbon metabolism COG0348 C LFTS_02371 151.160766200011 -0.341380666832588 0.220485055785906 -1.54831657690249 0.121546095266477 0.256505596631972 510 hypothetical protein NA NA NA NA NA NA NA LFTS_00652 1560.05246356762 0.209249663004302 0.135395449186295 1.54547042948533 0.122232516126164 0.257735398718952 804 adenylyltransferase and sulfurtransferase NA K11996 Folding, sorting and degradation Folding, sorting and degradation 04122 Sulfur relay system COG0476;COG0607 HP LFTS_01442 1449.88948738736 0.222950951898938 0.144391027009194 1.54407761006327 0.122569532227044 0.25819521056103 3606 DNA polymerase-3 subunit alpha NA K02337 Replication and repair; Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0587 L LFTS_00248 789.191006508302 0.280853970783218 0.181943062856737 1.54363659912862 0.122676393443395 0.25819521056103 414 hypothetical protein NA K02498 NA Translation 03010 Ribosome COG3071 S LFTS_00011 499.415233833783 -0.262903476366813 0.170353397579972 -1.54328284672687 0.122762163669806 0.25819521056103 1737 HNH endonuclease NA K00568 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00130 Ubiquinone and other terpenoid-quinone biosynthesis COG2227 H LFTS_01195 17.8907404009593 -0.607030819280544 0.394042366575081 -1.5405217072385 0.123433235714704 0.259385316727834 507 cyclic pyranopterin phosphate synthase NA K03637 Metabolism of cofactors and vitamins; Folding, sorting and degradation Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG0315 H LFTS_02082 732.580378819281 -0.208664780336471 0.135488069589865 -1.54009707989876 0.12353669147456 0.259385316727834 1374 phosphoglucosamine mutase NA K03431 Carbohydrate metabolism Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG1109 G LFTS_00483 279.22745901289 0.269122449436314 0.17483181188065 1.53932197202207 0.123725712486826 0.259562971512446 648 hypothetical protein NA K14998 NA Overview 01210 2-Oxocarboxylic acid metabolism COG3346 O LFTS_01934 368.714550974071 0.296531860991501 0.192744717817268 1.53846945508841 0.123933871391475 0.259780442056667 360 hypothetical protein NA NA NA NA NA NA NA LFTS_02500 217.021715863982 -0.321553763858833 0.209122997553285 -1.53762985238819 0.124139144047085 0.259991501348823 681 16S rRNA (guanine527-N7)-methyltransferase NA K03501 NA Folding, sorting and degradation 03060 Protein export COG0357 J LFTS_02046 848.492056989417 0.215856877354467 0.140742651154489 1.53369909962494 0.125103695386217 0.261399499676941 462 hypothetical protein NA NA NA NA NA NA NA LFTS_00833 837.331643013842 0.222853269340572 0.145306028399795 1.53368220021412 0.125107854840572 0.261399499676941 621 myosin NA NA NA NA NA NA NA LFTS_01148 154.622117911254 0.353657053365351 0.230605056222913 1.53360493979582 0.125126872331279 0.261399499676941 564 hypothetical protein NA NA NA NA NA NA NA LFTS_01587 851.93140021443 0.266872492968971 0.174362869090656 1.53055805035083 0.125878656151732 0.262749235258779 405 DNA-directed RNA polymerase subunit omega NA K03060 Nucleotide metabolism; Transcription Nucleotide metabolism 00230 Purine metabolism COG1758 K LFTS_00829 2447.2439298645 -0.20869129534867 0.136393454280617 -1.53006826060221 0.125999833565162 0.262781532083048 1764 Tetratricopeptide repeat-containing protein NA K12600 Folding, sorting and degradation Folding, sorting and degradation 03018 RNA degradation COG0457 R LFTS_00692 10199.9053573533 0.239929021911114 0.157048927973858 1.52773422274523 0.126578539509302 0.26376718291712 1854 NAD(P)-dependent iron-only hydrogenase diaphorase component flavoprotein NA K05587 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG1894 C LFTS_02257 5576.45491994489 0.234760674850298 0.154132934939498 1.52310520099062 0.12773238785708 0.26590106772301 1797 RNA polymerase%2C sigma 70 subunit%2C RpoD NA K03086 NA Replication and repair 03030 DNA replication COG0568 K LFTS_02234 1014.6429793943 0.250863703634093 0.164768902136073 1.5225185115752 0.127879210634891 0.26590106772301 2145 glycogen operon protein NA K02438 Carbohydrate metabolism Carbohydrate metabolism 00500 Starch and sucrose metabolism COG1523 G LFTS_01865 240.863632532458 0.279019524766063 0.183283091865372 1.52234186976185 0.127923442074304 0.26590106772301 1080 hypothetical protein NA NA NA NA NA NA NA LFTS_02353 672.761194994206 -0.252332285222179 0.166189847702064 -1.51833754414738 0.128929327618163 0.267768010408314 498 hypothetical protein NA NA NA NA NA NA NA LFTS_01981 1435.10128829866 0.219084987128041 0.144341421969435 1.51782478057084 0.129058576301758 0.267812705080275 756 proteasome alpha subunit NA K03432 Folding, sorting and degradation Folding, sorting and degradation 03050 Proteasome COG0638 O LFTS_02537 2014.23928543679 -0.186739285840531 0.123173537779456 -1.51606659358028 0.129502514404408 0.268509800508222 1599 2-isopropylmalate synthase NA K01649 Amino acid metabolism; Overview; Carbohydrate metabolism Overview 01210 2-Oxocarboxylic acid metabolism COG0119 E LFTS_00554 2.69002051047061 -0.583388768277668 0.385234954110387 -1.51437132599993 0.129931687544022 0.268855646201007 228 prevent-host-death family protein NA NA NA NA NA NA NA LFTS_01878 303.673075623672 0.301096525820735 0.198846437125324 1.51421634791962 0.129970976734354 0.268855646201007 834 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) NA K00979 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG1212 M LFTS_01831 557.899978387873 -0.275126482093561 0.181706404873983 -1.51412649589521 0.129993759748033 0.268855646201007 1470 two-component system%2C NtrC family%2C response regulator AtoC NA K07714 Signal transduction Signal transduction 02020 Two-component system COG2204 T LFTS_02044 84.2161396544184 -0.432567452801794 0.285945315043862 -1.51276286074294 0.13033990575418 0.269347469413874 357 Sugar phosphate permease NA K08153 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0477 GEPR LFTS_00319 1546.21518797356 -0.186368199463182 0.123303010787902 -1.51146511567152 0.130669989982055 0.269805311541021 2592 puromycin-sensitive aminopeptidase NA K08776 NA Cell growth and death 04214 Apoptosis - fly NA LFTS_01491 536.477014435538 0.218097550053773 0.144385620135449 1.51052126831726 0.130910466617263 0.270077526979682 879 hypothetical protein NA K02656 NA Overview 01200 Carbon metabolism COG3063 NW LFTS_00270 499.731150179926 -0.242873977750152 0.160856370302306 -1.50988100311916 0.131073790852235 0.270190252121605 654 hypothetical protein NA NA NA NA NA NA NA LFTS_01212 192.562030541061 0.298498219261563 0.19776105677076 1.50938826953972 0.131199589036902 0.270225499872193 312 hypothetical protein NA NA NA NA NA NA NA LFTS_02170 1519.04786200351 -0.199969451004085 0.132603889802568 -1.50802100377159 0.131549151456062 0.270665931511601 840 phosphatidate cytidylyltransferase NA K00981 Lipid metabolism; Signal transduction Lipid metabolism 00564 Glycerophospholipid metabolism COG0575 I LFTS_00052 2657.28143734021 -0.192473778155861 0.127684564396853 -1.50741617880794 0.131704014337789 0.270665931511601 1029 glyceraldehyde 3-phosphate dehydrogenase NA K00134 Energy metabolism; Overview; Signal transduction; Neurodegenerative diseases; Carbohydrate metabolism Overview 01200 Carbon metabolism COG0057 G LFTS_01892 285.684978322986 -0.290781214070037 0.192918424230932 -1.50727549859083 0.131740055160514 0.270665931511601 1575 apolipoprotein N-acyltransferase NA K03820 NA Drug resistance 01503 Cationic antimicrobial peptide (CAMP) resistance COG0815 M LFTS_02526 140.916085220654 0.328348069112464 0.218508832322943 1.50267641642597 0.132922507103106 0.272819077954399 573 TPR repeat-containing protein NA K12284 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism NA LFTS_02135 47.3072632201548 0.442258899124893 0.294388316343525 1.50229772912868 0.133020234871955 0.272819077954399 528 hypothetical protein NA NA NA NA NA NA NA LFTS_01918 681.390613764627 -0.211503201319475 0.140821701638323 -1.50192192580293 0.133117273354258 0.272819077954399 1098 carbamoyl-phosphate synthase small subunit NA K01956 Nucleotide metabolism; Amino acid metabolism Nucleotide metabolism 00240 Pyrimidine metabolism COG0505 EF LFTS_01643 1712.23819292926 0.362278659754135 0.241337484936709 1.50112884390564 0.133322239727175 0.273014075751035 660 Adenylate kinase NA K00939 Metabolism of cofactors and vitamins; Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0563 F LFTS_01928 474.105766905855 0.253151509615546 0.168772323166708 1.49995867133671 0.133625108447758 0.273409069630556 348 hypothetical protein NA NA NA NA NA NA NA LFTS_01800 269.446536028406 0.277259768643166 0.184921297163697 1.49933930215582 0.133785631351609 0.273512400937582 501 Transposase (or an inactivated derivative) NA K07493 NA Overview 01200 Carbon metabolism COG3328 X LFTS_01209 117.581410165566 -0.378655571578548 0.252779483895887 -1.49796797486344 0.134141571202084 0.274014746103847 336 hypothetical protein NA NA NA NA NA NA NA LFTS_00302 296.026835381922 0.253981782911071 0.169819407148492 1.49559927911529 0.134758111132308 0.275048164429325 381 Sulfur relay (sulfurtransferase) complex TusC component%2C DsrF/TusC family NA K07236 Folding, sorting and degradation Folding, sorting and degradation 04122 Sulfur relay system COG2923 P LFTS_01476 937.276939693646 0.205618918706266 0.137619541579519 1.49411134746046 0.135146518552543 0.275441212846361 1368 hypothetical protein NA NA NA NA NA NA NA LFTS_00155 139.406619129032 0.339925570679867 0.227525208072392 1.49401278899924 0.135172276618086 0.275441212846361 315 Nucleoid-associated protein NA K09747 NA Nucleotide metabolism 00230 Purine metabolism COG0718 R LFTS_00874 1138.02159575055 0.193110272501025 0.12953705284242 1.49077247215081 0.136021241396163 0.276944149148944 990 membrane fusion protein%2C multidrug efflux system NA K03543 NA Membrane transport 02010 ABC transporters COG1566 V LFTS_00105 364.765089870146 0.261801851284167 0.175996027312786 1.48754409563395 0.136871165998461 0.278446578291469 1143 glutamate 5-kinase NA K00931 Amino acid metabolism; Overview; Biosynthesis of other secondary metabolites Overview 01230 Biosynthesis of amino acids COG0263 E LFTS_02264 573.996778196464 0.283654352160149 0.191135749669537 1.48404656193607 0.137796568449116 0.279885505950269 768 cyclase NA K02500 Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG0107 E LFTS_01641 1266.94473796206 0.353729299269398 0.238358866868321 1.48401988949214 0.137803644120325 0.279885505950269 219 translation initiation factor IF-1 NA K02518 NA Translation 03010 Ribosome COG0361 J LFTS_02368 1305.42896364429 0.186159555450419 0.125558933592664 1.48264683462791 0.138168266840079 0.280396988868928 1557 exopolyphosphatase / guanosine-5'-triphosphate%2C3'-diphosphate pyrophosphatase NA K01524 Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0248 FTP LFTS_00713 640.536574851899 -0.259869427675214 0.175643040185108 -1.47953159659125 0.138998293102932 0.281851351267446 378 Tetratricopeptide repeat-containing protein NA K02498 NA Cell motility 02030 Bacterial chemotaxis COG3071 S LFTS_01637 2013.61029654959 0.28839578628287 0.195338549148803 1.47638951727434 0.139839355198979 0.283325702546587 465 large subunit ribosomal protein L17 NA K02879 Translation Translation 03010 Ribosome COG0203 J LFTS_00122 1548.55604029194 0.200250331681007 0.135794244293358 1.47465993660529 0.140303992198464 0.284035606356174 2451 ATP-dependent proteinase. Serine peptidase. MEROPS family S16 NA K01338 Cell growth and death Cell growth and death 04112 Cell cycle - Caulobacter COG0466 O LFTS_00743 14.0986041289237 -0.609809633072632 0.41394705394412 -1.47315852900103 0.140708294510039 0.284481584165033 264 hypothetical protein NA K08682 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00770 Pantothenate and CoA biosynthesis COG3124 I LFTS_01053 255.491549581441 -0.268655591364715 0.182387662062877 -1.47299213294426 0.140753157088894 0.284481584165033 624 hypothetical protein NA K06952 NA Replication and repair 03030 DNA replication COG3810 LFTS_00040 752.732378380825 -0.240381145107739 0.163427748348804 -1.47087105792275 0.14132599103651 0.285407322271945 1227 hypothetical protein NA K09800 NA Signal transduction 02020 Two-component system COG2911 U LFTS_00391 616.343821543087 0.267638218433586 0.182125392353517 1.46952720307162 0.141689848974306 0.285909873823154 1290 metabolite-proton symporter NA K08172 NA Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG0477 GEPR LFTS_01999 1407.78042235299 -0.209850450824884 0.142927999624502 -1.46822492007304 0.142043137276255 0.286390299488053 852 Dihydropteroate synthase NA K00796 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG0294 H LFTS_01852 299.306022111298 -0.331491229667304 0.225903941163308 -1.46739905448425 0.142267531560041 0.286610278329224 1065 2%2C4-dienoyl-CoA reductase NA K09461 Xenobiotics biodegradation and metabolism Xenobiotics biodegradation and metabolism 00627 Aminobenzoate degradation NA LFTS_02253 798.59466207837 0.208920760044972 0.142450772546658 1.46661724826057 0.142480205274165 0.286806307944595 1422 HD domain protein NA K06885 NA Replication and repair 03030 DNA replication COG1078 R LFTS_01343 355.157251638454 -0.24900996845425 0.170038349126314 -1.46443416872551 0.143075357886435 0.287771310441487 2043 4-alpha-glucanotransferase NA K01196 Carbohydrate metabolism Carbohydrate metabolism 00500 Starch and sucrose metabolism NA LFTS_02045 197.675749911356 -0.299783204466845 0.205600307527244 -1.45808733494779 0.144816471874302 0.290969908113051 606 transposase%2C IS605 OrfB family%2C central region NA K07496 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0675 X LFTS_01809 689.821896615971 0.289928013642926 0.198920563618827 1.45750649590199 0.144976619560579 0.290969908113051 1422 Glycosyltransferase involved in cell wall bisynthesis Lipopolysaccharide synthesis K12994 NA Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG0438 M LFTS_01265 108.504284207955 0.353958283268966 0.242876201732723 1.45736091368262 0.145016780431243 0.290969908113051 294 mRNA interferase HigB NA K01638 Carbohydrate metabolism; Overview Overview 01200 Carbon metabolism COG2225 C LFTS_00158 449.257464188667 -0.219444142097941 0.150641837591792 -1.45672772986604 0.145191552097518 0.291085643963249 252 hypothetical protein NA NA NA NA NA NA NA LFTS_01916 1374.72993612251 -0.183392952146723 0.126097208889853 -1.45437756918885 0.145841655301143 0.292153388459824 3243 carbamoyl-phosphate synthase large subunit NA K01955 Nucleotide metabolism; Amino acid metabolism Nucleotide metabolism 00240 Pyrimidine metabolism COG0458 EF LFTS_02351 516.524661366941 0.228255563294904 0.15727135698003 1.45134859695963 0.146682815514813 0.293601835241405 774 dihydrodipicolinate reductase NA K00215 Amino acid metabolism; Overview; Biosynthesis of other secondary metabolites Overview 01230 Biosynthesis of amino acids COG0289 E LFTS_00188 443.830547978424 -0.245602698439511 0.169618933519849 -1.4479674723976 0.147626147815309 0.295209937504814 405 glycine cleavage system H protein NA K02437 Carbohydrate metabolism; Amino acid metabolism Carbohydrate metabolism 00630 Glyoxylate and dicarboxylate metabolism COG0509 E LFTS_00014 229.960049039601 0.254891428161048 0.176076357503871 1.44761870233171 0.147723717721636 0.295209937504814 291 Transposase NA K07483 NA Replication and repair 03410 Base excision repair COG2963 X LFTS_02164 1988.33152778119 -0.193098865014688 0.133723993769688 -1.44401060401517 0.148735992530812 0.296994118418955 183 LSU ribosomal protein L32P NA K02911 Translation Translation 03010 Ribosome COG0333 J LFTS_02415 1383.96429336449 0.220133724361711 0.153025879497193 1.43853918752187 0.150281126886441 0.299691407419931 1212 Virginiamycin B lyase NA NA NA NA NA NA NA LFTS_02451 11197.3585275659 0.213013953567554 0.148093558885767 1.43837419513879 0.150327910318847 0.299691407419931 699 pyruvate ferredoxin oxidoreductase gamma subunit Reductive TCA cycle carbon dioxide fixation K00172 Carbohydrate metabolism; Overview; Energy metabolism; Xenobiotics biodegradation and metabolism Overview 01200 Carbon metabolism COG1014 C LFTS_01307 373.002020738652 -0.241292622701352 0.167969752216633 -1.43652425223652 0.150853220399481 0.30049768102012 852 Glycosyl transferase family 2 Lipopolysaccharide synthesis K00786 NA Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis NA LFTS_00556 100.941559386673 -0.356793182771518 0.249236263895538 -1.43154602462289 0.152273786246352 0.303082791146682 273 Putative zinc-finger NA NA NA NA NA NA NA LFTS_01546 703.761193543382 0.196428864364482 0.13730765234014 1.43057477873037 0.152552120133109 0.303082791146682 813 Exodeoxyribonuclease III NA K01142 Replication and repair Replication and repair 03410 Base excision repair COG0708 L LFTS_01742 37.2694553100597 -0.485475647460363 0.339577269706625 -1.42964706642405 0.152818339785629 0.303082791146682 414 hypothetical protein NA NA NA NA NA NA NA LFTS_00497 1116.58668730491 0.296312905665486 0.207264498817255 1.42963656273207 0.152821355985144 0.303082791146682 2898 maltooligosyl trehalose synthase NA K06044 Carbohydrate metabolism Carbohydrate metabolism 00500 Starch and sucrose metabolism COG3280 G LFTS_00090 3891.69855369416 0.188412775297694 0.1317994455234 1.42954148668434 0.152848659715386 0.303082791146682 1761 threonyl-tRNA synthetase NA K01868 Translation Translation 00970 Aminoacyl-tRNA biosynthesis COG0441 J LFTS_01629 1725.54179726183 0.182534268097429 0.127697797993264 1.4294237721081 0.15288246987045 0.303082791146682 912 ADP-L-glycero-D-manno-heptose 6-epimerase Lipopolysaccharide synthesis K03274 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG0451 M LFTS_01915 4094.21914769535 0.216820681759119 0.151822426573125 1.4281202497754 0.153257249934315 0.303476142613746 483 transcription elongation factor GreA NA K03624 NA Nucleotide metabolism 00240 Pyrimidine metabolism COG0782 K LFTS_02176 823.926262014634 0.190074146428283 0.133115888147444 1.42788474819587 0.153325034240895 0.303476142613746 300 sec-independent protein translocase protein TatB NA K03117 Folding, sorting and degradation; Membrane transport Folding, sorting and degradation 03060 Protein export COG1826 U LFTS_02421 2018.40111410009 -0.202646733387627 0.142068410397578 -1.42640248328619 0.153752197309341 0.304079524670662 1005 folate-binding protein YgfZ NA K06980 NA Carbohydrate metabolism 00052 Galactose metabolism COG0354 O LFTS_01898 2069.65279146712 -0.229836512443586 0.161417925183318 -1.42385991012192 0.154487028915116 0.30528994744275 657 Lon protease NA K07157 NA Overview 01200 Carbon metabolism COG2802 S LFTS_00289 741.906207911788 -0.203056135195744 0.142767146716602 -1.42228894998384 0.154942385402242 0.305946600563919 726 Outer membrane protein beta-barrel domain protein NA NA NA NA NA NA NA LFTS_01182 5.58271008421814 0.604459631762475 0.425482401308233 1.42064543657726 0.155419862321364 0.306645855341993 312 ferredoxin III%2C nif-specific Nitrogenase genes K03616 NA Signal transduction 02020 Two-component system COG2878 C LFTS_02380 2551.72136932136 0.207340160169585 0.146080460420975 1.41935587806932 0.155795288922061 0.307142813846347 603 Peroxiredoxin Oxidative stress response K02199 NA Nucleotide metabolism 00240 Pyrimidine metabolism COG0526 O LFTS_01560 603.122910422011 -0.221058586683677 0.156183793067446 -1.41537468351928 0.156958668334753 0.309191164405861 1503 adenosylcobyric acid synthase (glutamine-hydrolysing) NA K02232 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG1492 H LFTS_00885 811.300460474675 0.209789289283783 0.148404996736369 1.41362685824157 0.15747149102635 0.30988598589137 552 shikimate kinase NA K00891 Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG0703 E LFTS_01886 1360.43787721682 -0.250836608064658 0.17747999557246 -1.41332327204306 0.157560694355065 0.30988598589137 1008 putative oxidoreductase NA K05275 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00750 Vitamin B6 metabolism COG0667 R LFTS_01336 11537.7417823531 0.220392616007233 0.156118435135003 1.41170141640639 0.158037896136141 0.310578821971894 663 16S rRNA (guanine966-N2)-methyltransferase NA K08316 NA Cell growth and death 04112 Cell cycle - Caulobacter COG0742 J LFTS_02359 1210.60530406783 0.196697120395187 0.139706865945415 1.4079273703845 0.15915257746782 0.312509172881662 1044 voltage-gated potassium channel Role of potassium in the internal positive membrane potential K03499 NA Overview 01200 Carbon metabolism COG0569 P LFTS_00667 363.868949287426 -0.221543059480139 0.157398947332018 -1.40752567431607 0.159271569606221 0.312509172881662 717 outer membrane lipoprotein carrier protein NA K03634 NA Metabolism of cofactors and vitamins 00750 Vitamin B6 metabolism COG2834 M LFTS_00892 412.381432502495 0.230213585677745 0.163815492936727 1.40532242433666 0.159925423128649 0.313353117081284 450 7-cyano-7-deazaguanine reductase NA K09457 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG0780 J LFTS_00601 251.82016373623 -0.288701870314464 0.205448562615004 -1.40522701468334 0.159953783417598 0.313353117081284 1116 UDP-N-acetylglucosamine-N- acetylmuramylpentapeptide N-acetylglucosamine transferase NA K02563 Cell growth and death; Glycan biosynthesis and metabolism; Drug resistance Glycan biosynthesis and metabolism 00550 Peptidoglycan biosynthesis COG0707 M LFTS_01368 1173.5696841399 -0.231621168921776 0.164900630579403 -1.4046105712752 0.160137111395619 0.313465243251582 1203 GTP cyclohydrolase II /3%2C4-dihydroxy-2-butanone 4-phosphate synthase (EC 4.1.99.12) NA K14652 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00740 Riboflavin metabolism COG0108;COG0807 H LFTS_00131 169.96296808096 0.271379482907793 0.193396651577305 1.40322741213188 0.160549035802165 0.313819293770179 201 hypothetical protein NA NA NA NA NA NA NA LFTS_01870 2104.02848076508 0.238900531188224 0.170495131513787 1.40121614656724 0.161149447322918 0.313819293770179 951 Murein DD-endopeptidase MepM and murein hydrolase activator NlpD%2C containing LysM domain NA K08259 NA Overview 01200 Carbon metabolism NA LFTS_00558 73.3168333697515 -0.363590700064188 0.259486974187113 -1.40119056535765 0.161157094842109 0.313819293770179 462 mercuric ion transport protein Mercury resistance NA NA NA NA NA NA LFTS_01044 22.3300805925216 0.523906054534698 0.373908771087671 1.40116010921781 0.161166200082321 0.313819293770179 246 hypothetical protein NA NA NA NA NA NA NA LFTS_00827 672.854374822184 0.199246714299056 0.142216910708763 1.40100578268839 0.161212343882726 0.313819293770179 360 hypothetical protein NA K14945 NA Overview 01212 Fatty acid metabolism NA LFTS_00119 447.197737254405 -0.258365328388458 0.184426569872269 -1.40091163961569 0.161240497663894 0.313819293770179 480 hypothetical protein NA K02015 Membrane transport Membrane transport 02010 ABC transporters COG0609 P LFTS_00767 1675.38794310827 0.182210376584837 0.130069266619014 1.40087186866786 0.161252392406274 0.313819293770179 195 Zn-finger domain of CDGSH type-containing protein NA NA NA NA NA NA NA LFTS_01379 433.319665485934 -0.246521150886547 0.176011991818938 -1.40059292744179 0.161335837105303 0.313819293770179 2913 iron complex outermembrane recepter protein NA K02014 NA Metabolism of cofactors and vitamins 00785 Lipoic acid metabolism COG1629 P LFTS_01737 75.4500448490593 -0.398537424886696 0.284690492697918 -1.39989720453917 0.161544103290269 0.313819293770179 1470 DNA-3-methyladenine glycosylase II NA K13529 Replication and repair Replication and repair 03410 Base excision repair COG2169;COG0122 L LFTS_02197 343.720321196246 0.265475744322908 0.189655841028602 1.39977626253478 0.161580328248524 0.313819293770179 693 phosphoglycolate phosphatase NA K01091 Carbohydrate metabolism Carbohydrate metabolism 00630 Glyoxylate and dicarboxylate metabolism COG0546 C LFTS_01435 2762.8281530304 -0.182726334487827 0.130607953458873 -1.39904446588979 0.161799649301799 0.313999943922148 1314 N-acetylmuramoyl-L-alanine amidase NA K01448 Drug resistance Drug resistance 01503 Cationic antimicrobial peptide (CAMP) resistance COG0860 M LFTS_02519 846.937280194167 0.218411611578197 0.156259661548456 1.39774788588331 0.162188788880959 0.314509617127974 1047 Thiol-disulfide isomerase or thioredoxin NA K02199 NA Nucleotide metabolism 00240 Pyrimidine metabolism COG0526 O LFTS_00842 947.767119249384 0.200835006832578 0.143760932331871 1.39700684723547 0.16241151207033 0.314664471394553 246 SSU ribosomal protein S16P NA K02959 Translation Translation 03010 Ribosome COG0228 J LFTS_00145 681.5020215437 0.223460321916861 0.160002315126578 1.39660680372082 0.162531843196529 0.314664471394553 906 tetrapyrrole methylase family protein / MazG family protein NA K02499 NA Overview 01230 Biosynthesis of amino acids COG3956 R LFTS_02157 713.08983778832 0.224182291559555 0.160563773632599 1.39621962344089 0.162648369164119 0.314664471394553 756 ribonuclease-3 NA K03685 Translation; Cancers Translation 03008 Ribosome biogenesis in eukaryotes COG0571 K LFTS_00793 1973.29820930107 -0.193280768694779 0.138545734204988 -1.39506834911862 0.162995229547518 0.314849745610208 474 Nucleotide-binding universal stress protein%2C UspA family NA K06149 NA Cell growth and death 04112 Cell cycle - Caulobacter COG0589 T LFTS_02295 2694.37966539022 -0.186382850210719 0.133601932395889 -1.39506103593195 0.162997434674311 0.314849745610208 1299 Adenylosuccinate synthetase NA K01939 Amino acid metabolism; Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0104 F LFTS_00598 526.033262689509 -0.241767426618138 0.173514581676423 -1.39335509605178 0.16351243739491 0.3155993162762 1464 UDP-N-acetylmuramoylalanine--D-glutamate ligase NA K01925 Metabolism of other amino acids; Glycan biosynthesis and metabolism Metabolism of other amino acids 00471 D-Glutamine and D-glutamate metabolism COG0771 M LFTS_00565 269.046148431316 -0.265776237117344 0.190898075855396 -1.39224157145863 0.16384925807072 0.316004077241124 1104 UDP-galactopyranose mutase Extracellular polysaccharide production and export K01854 Carbohydrate metabolism Carbohydrate metabolism 00052 Galactose metabolism COG0562 M LFTS_00629 39036.6254600712 -0.334141391285644 0.240614825746633 -1.3886982659892 0.164924521710806 0.317831287576019 576 hypothetical protein NA NA NA NA NA NA NA LFTS_01531 24203.2465074835 -0.255134510518068 0.184055117970095 -1.38618536301458 0.165690309752772 0.319059728927492 531 cytochrome c oxidase cbb3-type subunit 2 Cytochrome cbb3 oxidase; Proton transporters K00405 Energy metabolism; Signal transduction Energy metabolism 00190 Oxidative phosphorylation COG2993 C LFTS_01012 146.374889389311 -0.286155227583722 0.206557428938303 -1.38535432520897 0.165944149951803 0.319121333434381 1098 transposase%2C IS605 OrfB family%2C central region NA K07496 NA Replication and repair 03410 Base excision repair COG0675 X LFTS_01591 1331.87059644139 0.175474874705506 0.126674692482748 1.38524018702002 0.165979036255292 0.319121333434381 576 elongation factor P NA K02356 NA Overview 01230 Biosynthesis of amino acids COG0231 J LFTS_01099 68.4109385008543 0.373355743838653 0.269965851241449 1.38297396549142 0.166672848818931 0.320207652367746 2010 hypothetical protein NA K14440 NA Amino acid metabolism 00310 Lysine degradation NA LFTS_00306 1569.84937689809 0.240514049966969 0.173982360575342 1.38240479765657 0.166847443826928 0.320295556257717 1098 GGDEF domain-containing protein%2C diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants Putative diguanylate cyclases (GGDEF domain-containing proteins) K02488 Cell growth and death; Signal transduction Signal transduction 02020 Two-component system COG3706 TK LFTS_00005 652.890985398341 0.221943539621961 0.160671723461957 1.38134784914105 0.167172032539029 0.320671043898168 816 Tetratricopeptide repeat-containing protein NA K05807 NA Nucleotide metabolism 00230 Purine metabolism COG4105 M LFTS_00139 553.960879273421 -0.235693620495984 0.171420682342758 -1.37494272730003 0.169149201343763 0.324213503886349 990 Phosphoesterase family protein NA K01114 Lipid metabolism; Cellular community - prokaryotes; Carbohydrate metabolism; Endocrine system Carbohydrate metabolism 00562 Inositol phosphate metabolism COG3511 M LFTS_00243 123.532560836947 -0.313277886935637 0.229545277001906 -1.36477600858255 0.172323461529966 0.330043239879427 714 Tetratricopeptide repeat-containing protein NA NA NA NA NA NA NA LFTS_01198 21.342709654678 -0.540695828897852 0.396859445372095 -1.36243658857835 0.173060143361002 0.33119901185177 294 molybdopterin synthase sulfur carrier subunit NA K03636 Folding, sorting and degradation Folding, sorting and degradation 04122 Sulfur relay system COG1977 H LFTS_02450 4088.0325143041 0.194677799315987 0.143737970923522 1.3543936794514 0.175610813022368 0.335821908595082 213 pyruvate ferredoxin oxidoreductase Reductive TCA cycle carbon dioxide fixation K00171 Carbohydrate metabolism; Overview; Energy metabolism; Xenobiotics biodegradation and metabolism Overview 01200 Carbon metabolism COG1144 C LFTS_01951 1157.12888457453 -0.238272918766827 0.176369690381058 -1.3509856384735 0.176700033219914 0.337444252055073 1239 tryptophan synthase beta chain NA K01696 Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG0133 E LFTS_00432 4129.14730782846 -0.291558496283287 0.215826963661412 -1.35089004328802 0.176730658155955 0.337444252055073 1338 B12 binding domain-containing protein NA K13602 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG1032 R LFTS_01952 374.002781038119 -0.234961192660786 0.174062101758794 -1.34986990439988 0.177057716869868 0.337809274089404 639 phosphoribosylanthranilate isomerase NA K01817 Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG0135 E LFTS_00464 225.349629633729 -0.304245286820297 0.226248240699801 -1.34474100607035 0.178708887371917 0.340473328901488 888 putative iron-dependent peroxidase Oxidative stress response K07223 NA Lipid metabolism 00564 Glycerophospholipid metabolism COG2837 P LFTS_02318 240.939641334582 -0.268110237712834 0.199385609672818 -1.34468198659266 0.178727954230266 0.340473328901488 1017 flagellar motor switch protein FliM Chemotaxis K02416 Cell motility Cell motility 02030 Bacterial chemotaxis COG1868 N LFTS_02480 1502.45723059624 0.170569228106754 0.127356966462839 1.33930033702965 0.180472919080129 0.343534208907504 1281 hypothetical protein NA K02012 Membrane transport Membrane transport 02010 ABC transporters COG1840 P LFTS_02306 383.895273578099 -0.228768847494892 0.171024392278096 -1.3376387101724 0.181014239210217 0.344145597933949 1101 Cellulase family 8 Cellulose production K15531 NA Glycan biosynthesis and metabolism 00550 Peptidoglycan biosynthesis COG3405 G LFTS_00290 325.67858501007 -0.257653469070054 0.192693921296706 -1.3371125946071 0.181185886672091 0.344145597933949 999 Holliday junction DNA helicase subunit RuvB NA K03551 Replication and repair Replication and repair 03440 Homologous recombination COG2255 L LFTS_01868 584.805089000665 0.213721907528256 0.15984699257676 1.33704052908987 0.181209407761681 0.344145597933949 531 hypothetical protein NA NA NA NA NA NA NA LFTS_02294 276.933253691068 -0.229795257696505 0.172973190953088 -1.32850215938277 0.184012270681482 0.349201912148217 315 hypothetical protein NA K06475 Immune system Immune system 04640 Hematopoietic cell lineage NA LFTS_01226 124.000393207193 0.298963068586112 0.225354396457439 1.32663517235873 0.184629395109753 0.349596576919545 678 hypothetical protein NA NA NA NA NA NA NA LFTS_02362 5875.36991706933 0.259102903405964 0.195312869038924 1.32660435884707 0.184639593214868 0.349596576919545 117 hypothetical protein NA NA NA NA NA NA NA LFTS_00373 3135.94993369798 0.192778883476302 0.145318376777134 1.3265967302398 0.184642118059277 0.349596576919545 561 5-methylcytosine-specific restriction endonuclease McrA NA K09952 NA Overview 01210 2-Oxocarboxylic acid metabolism COG3513 V LFTS_02101 1488.10993426161 -0.205485354285926 0.155102650007949 -1.32483458068186 0.185226022551266 0.350435229880097 1479 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit A NA K02433 Translation Translation 00970 Aminoacyl-tRNA biosynthesis COG0154 J LFTS_00543 140.896115241639 -0.278305071517781 0.210348474622084 -1.3230667444477 0.18581318274093 0.351278762200725 1512 O-antigen ligase Extracellular polysaccharide production and export K13009 NA Cell motility 02030 Bacterial chemotaxis COG3307 M LFTS_01416 260.940621324166 0.232287969519072 0.175663376651408 1.32234717302532 0.186052571204317 0.351464051682319 942 hypothetical protein NA NA NA NA NA NA NA LFTS_01340 247.994970621743 0.243300807734269 0.184158753770563 1.32114712308158 0.186452313222774 0.351951746903429 1239 lipoprotein-releasing system permease protein NA K09808 Membrane transport Membrane transport 02010 ABC transporters COG4591 M LFTS_02518 525.472531292 0.204196007438943 0.154810237378801 1.31900842538792 0.187166295751363 0.35294527716321 417 secondary thiamine-phosphate synthase enzyme NA NA NA NA NA NA NA LFTS_02187 575.567796855125 0.184609550734743 0.139991425389003 1.3187204160666 0.187262598784503 0.35294527716321 1476 squalene-associated FAD-dependent desaturase NA K02293 Metabolism of terpenoids and polyketides Metabolism of terpenoids and polyketides 00906 Carotenoid biosynthesis COG3349 R LFTS_02165 3863.21575937702 0.167352577219591 0.126965009987712 1.31809998074106 0.187470180963204 0.353068840814033 495 hypothetical protein NA K07040 NA Translation 03010 Ribosome COG1399 S LFTS_02146 494.447780414521 -0.193455425476704 0.146862581607361 -1.31725469727823 0.187753265031452 0.353146177800599 1347 N-acetylglutamate synthase NA K14682 Overview; Amino acid metabolism Overview 01210 2-Oxocarboxylic acid metabolism COG0548;COG1246 E LFTS_00369 1340.23508395122 -0.189525079376975 0.143892560529069 -1.31712910438262 0.187795352796618 0.353146177800599 924 TIGR00269 family protein NA K14168 Folding, sorting and degradation Folding, sorting and degradation 04122 Sulfur relay system NA LFTS_01947 361.645531393828 0.221155380486424 0.168371015982966 1.31350030285972 0.189014418926015 0.355169951209428 2301 LPS-assembly protein NA K04744 NA Energy metabolism 00190 Oxidative phosphorylation COG1452 M LFTS_00085 1071.84643803849 -0.229449269530281 0.174757690756937 -1.31295663462052 0.189197561209686 0.35524557187861 825 thiazole synthase NA K03149 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00730 Thiamine metabolism COG2022 H LFTS_01176 1.17024106745092 -0.385112366265878 0.293830954100856 -1.3106596187061 0.18997278725349 0.356431961594096 246 hypothetical protein NA NA NA NA NA NA NA LFTS_01239 268.961328216274 -0.296279049946035 0.22649576237096 -1.30809974917227 0.190839478535195 0.357659662290957 984 NADPH2:quinone reductase NA K00344 NA Biosynthesis of other secondary metabolites 00405 Phenazine biosynthesis COG0604 CR LFTS_00887 1421.98553831499 0.20974306470038 0.160369047822553 1.30787747104702 0.190914872027393 0.357659662290957 753 3-dehydroquinate synthase NA K01735 Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG0337 E LFTS_02166 2140.89696394167 0.166033165813496 0.127018293324322 1.30715947654528 0.191158555050279 0.357846511939002 1269 prolyl-tRNA synthetase NA K01881 Translation Translation 00970 Aminoacyl-tRNA biosynthesis COG0442 J LFTS_00178 879.498714453214 0.239133183469634 0.183105110593342 1.30598858051933 0.191556441001927 0.358321529218051 306 hypothetical protein NA NA NA NA NA NA NA LFTS_01979 1053.20572047756 -0.212379363534225 0.162845123262747 -1.30418006556792 0.19217219499183 0.359064330567233 1107 Dihydroorotate dehydrogenase NA K00226 Nucleotide metabolism Nucleotide metabolism 00240 Pyrimidine metabolism COG0167 F LFTS_01866 105.27507570103 0.327815675348377 0.251397378793382 1.30397411827353 0.192242407073607 0.359064330567233 771 Sulfite exporter TauE/SafE NA K07090 NA Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG0730 S LFTS_00927 22735.2565009282 -0.188911490169039 0.144935531211212 -1.30341737868088 0.192432306570221 0.359149184784961 2442 ATP-dependent Clp protease ATP-binding subunit ClpC Chaperones K03696 NA Translation 00970 Aminoacyl-tRNA biosynthesis COG0542 O LFTS_01917 424.428982418909 -0.221275503711242 0.169919979569043 -1.30223358237477 0.192836548418662 0.359633652939831 999 putative pyruvate formate lyase activating enzyme NA K04070 NA Nucleotide metabolism 00240 Pyrimidine metabolism COG1313 R LFTS_01958 393.475284741765 0.241540183742799 0.185773522789333 1.3001862704445 0.193537135093035 0.360669653554187 597 ADP-ribose pyrophosphatase NA K01515 Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0494 V LFTS_00773 753.181243930992 -0.184882748148264 0.142312245123441 -1.29913450517134 0.193897773336894 0.361071059562187 834 short chain dehydrogenase NA K07124 NA Replication and repair 03440 Homologous recombination COG0300 R LFTS_00387 117.038330155766 -0.335303681139034 0.258255103478013 -1.29834290445138 0.194169529356449 0.361111511494918 513 hypothetical protein NA NA NA NA NA NA NA LFTS_02531 4678.84515029052 0.206503952472773 0.159085817214399 1.29806639013249 0.194264522394215 0.361111511494918 582 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit NA K00201 Energy metabolism; Overview Overview 01200 Carbon metabolism COG1029 C LFTS_02370 700.480607424761 -0.210077398613763 0.161871646050923 -1.29780232510686 0.194355270466693 0.361111511494918 690 dTMP kinase NA K00943 Nucleotide metabolism Nucleotide metabolism 00240 Pyrimidine metabolism COG0125 F LFTS_01793 354.172051185647 0.263535182168523 0.203203494496318 1.2969028058388 0.19466463097947 0.361416185672115 1578 Transposase NA K07108 NA Metabolism of other amino acids 00450 Selenocompound metabolism COG2522 R LFTS_00721 2140.47986343135 0.17002660062751 0.131332164755896 1.2946303058625 0.195447792630423 0.362599412297934 480 general secretion pathway protein G NA K02456 Cellular community - prokaryotes; Membrane transport Membrane transport 03070 Bacterial secretion system COG2165 NUW LFTS_01140 496.219388117421 0.2058672978668 0.159208360915164 1.29306838336524 0.195987408948067 0.363102169838299 885 CRISP-associated protein Cas1 NA K15342 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG1518 V LFTS_02460 1155.21611628575 0.199812759121036 0.154534176832162 1.29300044311913 0.196010905841914 0.363102169838299 213 hypothetical protein NA NA NA NA NA NA NA LFTS_02185 812.969870670574 0.214307486171501 0.166019928795858 1.29085398196393 0.19675431502101 0.364207912987513 1059 CubicO group peptidase%2C beta-lactamase class C family NA K01453 Xenobiotics biodegradation and metabolism Xenobiotics biodegradation and metabolism 00930 Caprolactam degradation NA LFTS_00868 799.041665363652 -0.201289788917927 0.156089740084054 -1.2895773214148 0.19719745401643 0.364756600211938 879 nicotinate-nucleotide pyrophosphorylase [carboxylating] NA K00767 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00760 Nicotinate and nicotinamide metabolism COG0157 H LFTS_01137 224.23689501602 0.240455646833605 0.186644447803343 1.28830859778352 0.197638561412591 0.365300716484537 651 CRISPR-associated protein%2C Cse3 family NA K05682 Membrane transport Membrane transport 02010 ABC transporters NA LFTS_00828 1304.47861672179 0.173344166821217 0.134716541220323 1.28673261093989 0.198187502421879 0.366043187979786 948 exopolyphosphatase / guanosine-5'-triphosphate%2C3'-diphosphate pyrophosphatase NA K01524 Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0248 FTP LFTS_00858 1807.36690563289 0.167086170998955 0.130107717652748 1.28421414204575 0.199067038278884 0.367333913481886 2223 diguanylate cyclase (GGDEF) domain-containing protein Putative diguanylate cyclases (GGDEF domain-containing proteins) K13590 Cell growth and death Cell growth and death 04112 Cell cycle - Caulobacter COG2199 T LFTS_01681 730.354346635248 0.179978221033666 0.140182405827134 1.28388594825235 0.199181864591144 0.367333913481886 570 hypothetical protein NA K02496 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG2959 S LFTS_00084 1948.00927820165 -0.225934507866077 0.176129960653587 -1.28277157973393 0.199572113785453 0.36778078196489 1926 acetyl-CoA synthetase NA K01895 Carbohydrate metabolism; Overview; Energy metabolism Overview 01200 Carbon metabolism COG0365 I LFTS_00468 658.700029011723 0.21260783797609 0.165839164196214 1.28201223761922 0.199838353365153 0.36779571698593 1173 cysteine desulfurase NA K04487 Metabolism of cofactors and vitamins; Folding, sorting and degradation Metabolism of cofactors and vitamins 00730 Thiamine metabolism COG1104 E LFTS_01364 421.09158191329 -0.213373019083808 0.166496072490029 -1.28154986416623 0.200000597178783 0.36779571698593 1473 cysteinyl-tRNA synthetase NA K01883 Translation Translation 00970 Aminoacyl-tRNA biosynthesis COG0215 J LFTS_01715 672.827402556598 0.205659818926093 0.160485792534736 1.28148302524399 0.200024058473442 0.36779571698593 327 hypothetical protein NA K01907 Amino acid metabolism; Carbohydrate metabolism Carbohydrate metabolism 00650 Butanoate metabolism COG0365 I LFTS_01654 1495.86965911909 0.22529749869852 0.175985728386666 1.28020323445495 0.200473668692222 0.368349992881643 285 SSU ribosomal protein S19P NA K02965 Translation Translation 03010 Ribosome COG0185 J LFTS_00970 77.584264093091 -0.395086200156815 0.308968162184091 -1.27872787074227 0.200992901565291 0.369031280126523 273 hypothetical protein NA NA NA NA NA NA NA LFTS_01816 331.017727383386 0.277641027249223 0.2176877752775 1.27540936506562 0.202164385650189 0.370908238174443 1089 Glycosyltransferase involved in cell wall bisynthesis Lipopolysaccharide synthesis K12994 NA Membrane transport 02010 ABC transporters COG0438 M LFTS_00679 575.109677558353 0.211694158890629 0.166046912423256 1.27490572273345 0.20234261329397 0.370961457705611 294 Exodeoxyribonuclease VII small subunit NA K03602 Replication and repair Replication and repair 03430 Mismatch repair COG1722 L LFTS_02532 187.210223977912 0.239006762493249 0.187654362667943 1.27365417512927 0.202786003470376 0.371500371869827 513 hypothetical protein NA NA NA NA NA NA NA LFTS_00411 831.397696762663 -0.211252696797694 0.166059744434655 -1.27214875294971 0.203320271848347 0.37220485700662 807 tRNA pseudouridine38-40 synthase NA K06173 NA Amino acid metabolism 00310 Lysine degradation COG0101 J LFTS_00862 1931.83597397437 0.206939494341511 0.162860579051883 1.27065429550994 0.203851661888358 0.372903040069506 1083 recombination protein RecA NA K03553 Replication and repair Replication and repair 03440 Homologous recombination COG0468 L LFTS_00473 1662.81542365195 -0.19190433005025 0.151217176783778 -1.26906436247418 0.204418109462425 0.373664279502638 414 monothiol glutaredoxin Oxidative stress response K07390 NA Translation 00970 Aminoacyl-tRNA biosynthesis COG0278 O LFTS_01832 39.0438901274519 0.418247047355804 0.330331988100605 1.26614152556253 0.205462417959647 0.375297260137901 306 hypothetical protein NA NA NA NA NA NA NA LFTS_01796 337.398395482764 0.225982845048276 0.178595877349791 1.26533069184836 0.205752808791149 0.37555174937944 279 hypothetical protein NA NA NA NA NA NA NA LFTS_00381 53.675857840569 -0.401328981910897 0.317542251153478 -1.26386010193309 0.206280244429135 0.376238215444483 702 hypothetical protein NA NA NA NA NA NA NA LFTS_00285 260.708833498044 0.223019078351375 0.176842278367498 1.26111855383313 0.207266136829911 0.377504647055919 195 prevent-host-death family protein NA NA NA NA NA NA NA LFTS_00257 288.485807036515 -0.260128310225811 0.206273447964057 -1.26108480171979 0.207278295748725 0.377504647055919 597 HslV component of HslUV peptidase. Threonine peptidase. MEROPS family T01B NA K01419 NA Nucleotide metabolism 00230 Purine metabolism COG0638 O LFTS_02379 995.710797307843 -0.221071376386002 0.175683244273184 -1.25835208303781 0.208264452974209 0.378649845459642 516 Peroxiredoxin Oxidative stress response K02199 NA Overview 01200 Carbon metabolism COG0526 O LFTS_02222 47.7499903365774 -0.402145579223082 0.319605550607711 -1.25825592971845 0.208299213699141 0.378649845459642 702 conjugal transfer/type IV secretion protein DotA/TraY NA K12202 NA Lipid metabolism 00564 Glycerophospholipid metabolism NA LFTS_02405 1703.43488709263 0.232924998297507 0.18514372458053 1.25807665814886 0.208364034026062 0.378649845459642 846 rod shape-determining protein MreC NA K03570 NA Overview 01200 Carbon metabolism COG1792 D LFTS_00008 2383.12226806559 0.167546969807606 0.133254019277656 1.25735021514432 0.208626848180064 0.378850507359853 1584 leucyl aminopeptidase NA K01255 Metabolism of other amino acids Metabolism of other amino acids 00480 Glutathione metabolism COG0260 E LFTS_02005 195.978318635334 -0.310298024232079 0.247012753060021 -1.25620244456237 0.209042580679375 0.379328361729143 660 transcriptional regulator%2C TetR family NA K09017 NA Membrane transport 02060 Phosphotransferase system (PTS) COG1309 K LFTS_02178 847.24091944534 0.191072059131231 0.152257916105146 1.25492364547589 0.209506479332997 0.379892857492218 615 ribosomal-protein-alanine N-acetyltransferase NA K03789 NA Energy metabolism 00910 Nitrogen metabolism COG0456 J LFTS_02399 555.561388693167 0.217051668710384 0.173225652106808 1.25299957639388 0.210205860859404 0.380652361682247 399 dihydroneopterin aldolase NA K01633 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG1539 H LFTS_01961 1549.4058273379 -0.197102060242146 0.157313041620324 -1.25292892573938 0.210231573849447 0.380652361682247 468 hypothetical protein NA NA NA NA NA NA NA LFTS_01615 479.561809698747 -0.192030022278901 0.153453443782816 -1.25138946083662 0.210792420517984 0.380958777432365 624 hypothetical protein NA K02415 NA Membrane transport 03070 Bacterial secretion system COG1580 N LFTS_00882 1407.58346578215 0.167234566702405 0.133661037751273 1.25118411106166 0.210867313791668 0.380958777432365 867 hypothetical protein NA K06958 NA Cellular community - prokaryotes 02024 Quorum sensing COG1660 T LFTS_01369 483.705990329147 -0.230659226977935 0.184404247191862 -1.25083467702318 0.21099480038529 0.380958777432365 486 6%2C7-dimethyl-8-ribityllumazine synthase NA K00794 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00740 Riboflavin metabolism COG0054 H LFTS_02172 1091.17850411029 0.175965901595267 0.140684631243627 1.25078269061631 0.211013771731443 0.380958777432365 1929 hypothetical protein NA NA NA NA NA NA NA LFTS_00384 170.025389426204 -0.277332628874029 0.222116527019677 -1.24859069514202 0.211814817374511 0.382127457179269 1767 hypothetical protein NA K09817 Membrane transport Membrane transport 02010 ABC transporters COG1121 P LFTS_00491 565.772502399409 0.229220304324121 0.183769430510002 1.24732554096719 0.212278156029689 0.382685638788838 1278 MFS transporter%2C MHS family%2C proline/betaine transporter NA K03762 NA Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG0477 GEPR LFTS_01304 407.459149181132 -0.196456435198986 0.157589340724783 -1.24663530093752 0.212531251805963 0.382864269557698 1209 heptosyltransferase-1 Lipopolysaccharide synthesis K02841 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG0859 M LFTS_02461 1487.50846586864 -0.179948344820973 0.144519991491735 -1.24514500010376 0.213078455351274 0.383572078206566 1314 glutamate-1-semialdehyde 2%2C1-aminomutase NA K01845 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0001 H LFTS_00322 745.789648780057 -0.177989679850069 0.143070404544823 -1.2440705708238 0.213473591071412 0.383753939622702 2106 Excinuclease ABC subunit B NA K03702 Replication and repair Replication and repair 03420 Nucleotide excision repair COG0556 L LFTS_02319 359.586840011444 0.197940220296603 0.15911198839541 1.24403083823389 0.213488213394287 0.383753939622702 1143 HlyD family secretion protein NA K02005 NA Energy metabolism 00190 Oxidative phosphorylation COG0845 MV LFTS_02047 3895.08572595201 0.188671396619542 0.151811301810119 1.24280204681682 0.213940788095244 0.384152082814398 390 hypothetical protein NA NA NA NA NA NA NA LFTS_01194 37.0022319981939 -0.428471398490255 0.344821070065948 -1.24259053661747 0.21401875892918 0.384152082814398 501 molybdenum cofactor synthesis domain-containing protein NA K15376 Metabolism of cofactors and vitamins; Nervous system Metabolism of cofactors and vitamins 00790 Folate biosynthesis NA LFTS_02027 15.8592748190799 -0.49924030633254 0.402002893681282 -1.24188236995217 0.214279965727605 0.384343430590784 228 hypothetical protein NA NA NA NA NA NA NA LFTS_01713 160.891535462167 0.525076565843744 0.423378345550837 1.24020647574829 0.214899033798455 0.385175917824772 231 hypothetical protein NA NA NA NA NA NA NA LFTS_01365 81.2130969120712 -0.324939177863885 0.262263183476366 -1.23898129183339 0.215352426403922 0.385710469769561 579 23S rRNA (guanosine2251-2'-O)-methyltransferase NA K03218 NA Metabolism of cofactors and vitamins 00760 Nicotinate and nicotinamide metabolism COG0566 J LFTS_01356 1032.42646161865 -0.160312155005185 0.129550599934533 -1.23744818693389 0.215920738727631 0.386444387208101 1203 2%2C3-bisphosphoglycerate-independent phosphoglycerate mutase Oxidative stress response K15635 Energy metabolism; Overview; Amino acid metabolism; Carbohydrate metabolism Overview 01200 Carbon metabolism COG3635 G LFTS_01117 38.8978415144541 0.389949243600964 0.315228262756662 1.237037695132 0.216073088583773 0.386444387208101 519 hypothetical protein NA K02650 Signal transduction Signal transduction 02020 Two-component system COG2165 NUW LFTS_02107 1364.80495290549 -0.171845041935081 0.139266890237863 -1.23392603684606 0.217230466389654 0.388235039140676 1410 bifunctional UDP-N-acetylglucosamine pyrophosphorylase / Glucosamine-1-phosphate N-acetyltransferase NA K04042 Carbohydrate metabolism Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG1207 M LFTS_00070 490.021399834942 -0.183557325165869 0.14914437346691 -1.23073583601593 0.218421680407096 0.39008354704888 882 Glyoxylase%2C beta-lactamase superfamily II NA K01069 Carbohydrate metabolism Carbohydrate metabolism 00620 Pyruvate metabolism COG0491 R LFTS_02200 930.825700983035 0.251661689743129 0.204728839600404 1.22924396110645 0.218980351020017 0.390800540298466 678 phage shock protein A (PspA) family protein NA K03969 NA Translation 03010 Ribosome COG1842 KT LFTS_00278 400.669823001609 0.187845346245646 0.153212375657908 1.22604551648665 0.220181546983232 0.392662357102091 690 NAD(P)H-flavin reductase NA K00523 Carbohydrate metabolism Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG0543 HC LFTS_02130 239.866424639411 0.233828036061751 0.190931847313533 1.22466754159549 0.2207005084346 0.393305708937933 495 Ribosomal protein S18 acetylase RimI NA K03789 NA Translation 03010 Ribosome COG0456 J LFTS_01138 681.122089268639 0.230295561069168 0.188176883729296 1.22382492740428 0.221018278619445 0.393589857197665 1404 CRISPR-associated protein Cas7/Cse4/CasC%2C subtype I-E/ECOLI NA NA NA NA NA NA NA LFTS_00665 657.100987985772 -0.1796517709772 0.146923902759198 -1.22275387192539 0.221422672786579 0.39402774842336 909 cation diffusion facilitator family transporter Cadmium/cobalt/zinc resistance K13283 NA Cellular community - prokaryotes 02024 Quorum sensing COG0053 P LFTS_00707 761.796986998506 0.178677575337498 0.146261108949194 1.2216342171969 0.221845982955626 0.394402617089337 243 Fe-S cluster biosynthesis and repair protein YggX NA NA NA NA NA NA NA LFTS_02402 778.249975686835 0.214772345079853 0.175847215656587 1.22135766709712 0.221950628040218 0.394402617089337 1092 rod shape determining protein RodA NA K05837 NA Glycan biosynthesis and metabolism 00550 Peptidoglycan biosynthesis COG0772 D LFTS_00628 3324.86016749136 -0.157917253836939 0.129368039713211 -1.22068212664439 0.222206397605532 0.394575074605252 1380 oxygen-independent coproporphyrinogen-3 oxidase NA K02495 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0635 H LFTS_00357 98.6922683847832 0.293802504520702 0.24098399915154 1.21917847473328 0.222776459966313 0.395199349392166 1140 AcrB/AcrD/AcrF family protein NA K03296 NA Amino acid metabolism 00260 Glycine, serine and threonine metabolism COG0841 V LFTS_02228 939.873118871738 0.234713258315666 0.192558936802013 1.21891646377854 0.222875900180136 0.395199349392166 963 hypothetical protein NA K07489 NA Overview 01200 Carbon metabolism COG3677 X LFTS_01065 25.1708850877961 -0.450177335721861 0.369894170651623 -1.21704360717231 0.223587624877605 0.39604589910875 1137 ERF superfamily protein NA NA NA NA NA NA NA LFTS_01220 1618.1546567812 -0.469228831432496 0.385618293765646 -1.21682202068365 0.223671939802367 0.39604589910875 1662 NAD(P)H-quinone oxidoreductase subunit 5 NADH dehydrogenase K05577 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG1009 CP LFTS_00787 477.862721720637 -0.237914290382732 0.195911109140213 -1.21439918045922 0.224595328228028 0.397397854786389 255 hypothetical protein NA K12569 Cardiovascular diseases Cardiovascular diseases 05410 Hypertrophic cardiomyopathy (HCM) NA LFTS_01906 648.67486579605 0.212933821406076 0.175469640547879 1.21350805040245 0.224935638360722 0.397455211103218 1755 aspartyl-tRNA synthetase NA K01876 Translation Translation 00970 Aminoacyl-tRNA biosynthesis COG0173;COG0017 J LFTS_00142 1192.08284973117 0.166759704056278 0.137423043576015 1.2134770102369 0.224947498802183 0.397455211103218 243 TusA-related sulfurtransferase NA K04085 Folding, sorting and degradation Folding, sorting and degradation 04122 Sulfur relay system COG0425 O LFTS_02536 1321.11828293698 0.159306088630154 0.131370152687649 1.21265055547988 0.225263451327338 0.397547974967411 1113 3-isopropylmalate dehydrogenase NA K00052 Amino acid metabolism; Overview; Carbohydrate metabolism Overview 01210 2-Oxocarboxylic acid metabolism COG0473 CE LFTS_00236 1014.49279794094 0.168350437855299 0.13886079101344 1.21236842039165 0.225371383717303 0.397547974967411 228 hypothetical protein NA NA NA NA NA NA NA LFTS_00450 1122.96214357018 -0.182512035586449 0.150576895214189 -1.21208526266153 0.225479744450543 0.397547974967411 1998 basic amino acid/polyamine antiporter%2C APA family NA K03294 NA Metabolism of terpenoids and polyketides 00523 Polyketide sugar unit biosynthesis COG0531 E LFTS_02131 370.105179089779 0.222628309977049 0.183785353170892 1.2113495778417 0.225761455218124 0.397762563906631 531 YacP-like NYN domain protein NA K06962 NA Translation 03010 Ribosome COG3688 R LFTS_01211 152.137370936176 0.285384137610576 0.23582346174678 1.2101600726946 0.226217475692391 0.398258020014306 573 putative transposase NA K07496 NA Signal transduction 02020 Two-component system COG0675 X LFTS_02138 532.364006331369 -0.189509855398486 0.156648110160358 -1.20978066830482 0.226363066082146 0.398258020014306 1359 NADH dehydrogenase NA K03885 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG1252 C LFTS_00489 550.722015317016 0.185475969234296 0.153413552548881 1.20899337869905 0.22666538919052 0.398507890755044 900 Glucose-1-phosphate thymidylyltransferase Extracellular polysaccharide production and export K00973 Biosynthesis of other secondary metabolites; Metabolism of terpenoids and polyketides Metabolism of terpenoids and polyketides 00523 Polyketide sugar unit biosynthesis COG1209 M LFTS_01957 2333.52503553859 -0.14752514725296 0.122221065604687 -1.20703535452813 0.227418528738614 0.399316852700984 1422 PAS domain S-box-containing protein Nitrogenase genes K02584 Signal transduction Signal transduction 02020 Two-component system COG3604 KT LFTS_02307 112.224457144908 -0.308331943693961 0.255461179514843 -1.20696202953234 0.22744676726653 0.399316852700984 2214 cellulose synthase subunit Cellulose production NA NA NA NA NA NA LFTS_01489 650.571623549432 0.168934287871136 0.140085113696365 1.20594032737341 0.227840499765798 0.399725816808592 1149 5-(carboxyamino)imidazole ribonucleotide synthase NA K01589 Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0026 F LFTS_00998 70.9451902122664 0.338276768594211 0.280637897021301 1.20538520344077 0.228054630918867 0.399793880905476 636 Phosphoadenosine phosphosulfate reductase family protein NA K00390 Energy metabolism Energy metabolism 00920 Sulfur metabolism COG0175 EH LFTS_00185 36.6433524900285 -0.401837728376677 0.333473594371199 -1.205006138895 0.228200932021267 0.399793880905476 192 hypothetical protein NA NA NA NA NA NA NA LFTS_00111 209.976520716863 -0.224524289267511 0.18657999918373 -1.20336740406144 0.228834175877938 0.400404659006808 2214 ATP-dependent DNA helicase DinG NA K03722 NA Glycan biosynthesis and metabolism 00514 Other types of O-glycan biosynthesis COG1199 L LFTS_01240 292.328197014196 0.271927694594907 0.225990507850638 1.2032704257412 0.228871689641462 0.400404659006808 411 Phenazine biosynthesis-like protein NA K06998 Cellular community - prokaryotes;NA Biosynthesis of other secondary metabolites 00405 Phenazine biosynthesis COG0384 R LFTS_00128 1297.20115511184 -0.151693272425892 0.126130405534562 -1.20267013955113 0.229103993541528 0.400529203898902 2235 RNAse R NA K12573 Folding, sorting and degradation Folding, sorting and degradation 03018 RNA degradation COG0557 K LFTS_00071 562.152384941455 0.173019359080581 0.143994808378618 1.2015666469422 0.229531470283466 0.400994543306181 1086 hypothetical protein NA K07286 NA Carbohydrate metabolism 00620 Pyruvate metabolism COG3056 S LFTS_02132 421.126672969992 0.21762774789976 0.181202666881814 1.2010184598536 0.229744040716862 0.401084048611039 1431 amino acid/polyamine/organocation transporter%2C APC superfamily NA K03294 NA Translation 03010 Ribosome COG0531 E LFTS_00023 427.351207222199 -0.281271046388657 0.23494505306812 -1.19717798998349 0.231237186802845 0.40332733934392 993 NTE family protein NA K07001 NA Cell growth and death 04112 Cell cycle - Caulobacter COG1752 R LFTS_02358 1174.63835818069 -0.180187345656186 0.150557058606354 -1.19680436987882 0.231382814628203 0.40332733934392 1254 acetylornithine/N-succinyldiaminopimelate aminotransferase NA K00818 Overview; Amino acid metabolism Overview 01210 2-Oxocarboxylic acid metabolism COG0160;COG4992 E LFTS_01102 40.7142260213185 0.389357404823955 0.325423553904446 1.19646350165017 0.231515733404575 0.40332733934392 1164 hypothetical protein NA K06871 NA Amino acid metabolism 00350 Tyrosine metabolism COG0641 O LFTS_00818 1688.13154713526 -0.195351875357254 0.163426830652806 -1.19534763402633 0.23195123616089 0.403803062392137 1146 hypothetical protein NA NA NA NA NA NA NA LFTS_00507 835.062097360483 0.3024926895387 0.253529991704878 1.19312388843848 0.232820857142447 0.404931943969872 1044 putative zinc-type alcohol dehydrogenase-like protein NA K13979 NA Carbohydrate metabolism 00500 Starch and sucrose metabolism COG1064 G LFTS_00029 1439.88934270131 -0.145946313097395 0.122381691185947 -1.19255022285682 0.233045570393284 0.404931943969872 1107 diguanylate cyclase NA K13590 Cell growth and death Cell growth and death 04112 Cell cycle - Caulobacter COG2199 T LFTS_02254 1169.002434248 0.199266310252522 0.167107887397064 1.19244108316112 0.233088339429158 0.404931943969872 405 ribonuclease HI NA K03469 Replication and repair Replication and repair 03030 DNA replication COG0328 L LFTS_01778 1349.66335399467 -0.22854079565253 0.191931609389848 -1.19074078719531 0.233755360630789 0.405807141430267 966 GDP-L-fucose synthase NA K02377 Carbohydrate metabolism Carbohydrate metabolism 00051 Fructose and mannose metabolism COG0451 M LFTS_00147 2225.23913239997 -0.166812766001969 0.140328787656041 -1.18872804923565 0.23454669925117 0.406896786000286 1362 regulatory protein%2C Fis family NA K02481 NA Overview 01230 Biosynthesis of amino acids COG2204 T LFTS_02504 1645.27982387889 0.218143133167522 0.183709278653369 1.18743666496631 0.23505542487988 0.407260902131525 453 large subunit ribosomal protein L9 NA K02939 Translation Translation 03010 Ribosome COG0359 J LFTS_01123 198.045922393684 0.22132385777351 0.186399395205557 1.18736360453015 0.235084229508744 0.407260902131525 2061 type II and III secretion system protein NA K12282 NA Metabolism of terpenoids and polyketides 00900 Terpenoid backbone biosynthesis COG1450 U LFTS_00808 2791.68695324447 0.17831693825502 0.150281314575805 1.18655428825833 0.235403475733869 0.407529972614484 270 SSU ribosomal protein S15P NA K02956 Translation Translation 03010 Ribosome COG0184 J LFTS_00811 1690.91438016583 -0.141732478457501 0.119667561852967 -1.18438511040816 0.236260651529505 0.408729283021816 1236 putative Zn-dependent peptidase NA K01412 NA Metabolism of cofactors and vitamins 00770 Pantothenate and CoA biosynthesis NA LFTS_01362 721.899012958758 0.159934869119271 0.135122037134349 1.18363275533103 0.236558468310881 0.408746872716086 801 5'-nucleotidase /3'-nucleotidase /exopolyphosphatase NA K03787 Nucleotide metabolism; Metabolism of cofactors and vitamins Nucleotide metabolism 00230 Purine metabolism COG0496 L LFTS_02226 440.551195118764 0.276010431864958 0.233214607948297 1.18350404502169 0.236609444354209 0.408746872716086 1101 three-Cys-motif partner protein NA NA NA NA NA NA NA LFTS_00705 780.820014950694 0.17192369468125 0.145314596965207 1.18311372891475 0.23676407751857 0.408746872716086 3264 Superfamily II DNA or RNA helicase%2C SNF2 family NA K15192 NA Signal transduction 02020 Two-component system NA LFTS_02229 406.990572883004 -0.18227126144307 0.154370490060482 -1.18073902189244 0.23770641466176 0.410088929111127 1197 hypothetical protein NA K07404 Carbohydrate metabolism; Overview Overview 01200 Carbon metabolism COG2706 G LFTS_00235 168.107718670089 -0.268697954741635 0.228707110298123 -1.1748561485097 0.240052272012192 0.413848785174973 708 3-oxoacyl-[acyl-carrier protein] reductase NA K00059 Lipid metabolism; Overview; Metabolism of cofactors and vitamins Overview 01212 Fatty acid metabolism COG1028 IQR LFTS_00804 4381.5265005889 0.177079296799633 0.15093763378211 1.17319512942186 0.240717564777057 0.414695576061277 2625 bacterial translation initiation factor 2 (bIF-2) NA K02519 NA Translation 03010 Ribosome COG0532 J LFTS_02058 195.786973722154 0.255686976843932 0.218014624839566 1.17279736179207 0.240877076360613 0.414695576061277 717 hypothetical protein NA K07289 NA Cell growth and death 04112 Cell cycle - Caulobacter COG2982 M LFTS_01407 390.188107502077 0.197354195944185 0.16857563230814 1.17071603553852 0.241712937439461 0.415846617629412 1233 DNA repair exonuclease SbcCD nuclease subunit NA K03547 NA Transport and catabolism 04144 Endocytosis COG0420 L LFTS_01493 452.47553432803 -0.194043602260954 0.165899766296129 -1.16964361429292 0.242144418005417 0.416150415033357 1452 GGDEF domain-containing protein%2C diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants Putative diguanylate cyclases (GGDEF domain-containing proteins) K13590 Cell growth and death Cell growth and death 04112 Cell cycle - Caulobacter COG2199 T LFTS_01605 985.986614335912 0.180320657830651 0.154193339798658 1.16944517880026 0.242224316393109 0.416150415033357 522 putative OsmC-related protein NA K07397 NA Metabolism of cofactors and vitamins 00780 Biotin metabolism COG1765 R LFTS_02199 1003.63175278688 0.254266513460896 0.217562715558272 1.16870444831708 0.242522729125003 0.416323982164925 657 hypothetical protein NA K09942 NA Carbohydrate metabolism 00630 Glyoxylate and dicarboxylate metabolism COG3330 S LFTS_01036 29.860397749269 0.405695344914402 0.347233918572726 1.168363236466 0.242660277617448 0.416323982164925 363 hypothetical protein NA K09940 NA Carbohydrate metabolism 00500 Starch and sucrose metabolism COG3296 S LFTS_00337 2972.82828673062 0.185083165008371 0.15854313848285 1.16739940169906 0.243049112641138 0.41670351312129 213 prokaryotic ubiquitin-like protein Pup NA K13570 NA Folding, sorting and degradation 03050 Proteasome NA LFTS_01125 9.3051030692371 0.502823941195776 0.430936626173041 1.16681644273576 0.243284505297159 0.416819627959158 537 hypothetical protein NA K02456 Cellular community - prokaryotes; Membrane transport Membrane transport 03070 Bacterial secretion system COG2165 NUW LFTS_01270 36.0321510421674 -0.384178884788969 0.330070532176882 -1.16392966756297 0.244452515494289 0.418532337134162 372 Acetyltransferase (GNAT) domain-containing protein NA K03789 NA Translation 03010 Ribosome COG0456 J LFTS_01150 207.730742803227 -0.215521064439333 0.18528889483127 -1.16316233973759 0.244763643097353 0.41877661165865 1257 HDIG domain-containing protein NA K07814 NA Signal transduction 02020 Two-component system COG3437 T LFTS_01867 628.294193884164 0.210662063119602 0.181221148943449 1.16245848979437 0.245049276679725 0.418976961365747 1377 two-component system%2C NtrC family%2C nitrogen regulation response regulator GlnG Nitrate/nitrite regulation K07714 Signal transduction Signal transduction 02020 Two-component system COG2204 T LFTS_01417 139.672285723291 0.23868088062992 0.205420882985441 1.16191147249054 0.245271426522693 0.41906856792812 96 ORF6N domain-containing protein NA NA NA NA NA NA NA LFTS_00599 174.472948676078 -0.241236836392323 0.208574215544572 -1.15659951429026 0.247436020804932 0.422476612445783 756 cell division protein FtsW NA K03588 Cell growth and death Cell growth and death 04112 Cell cycle - Caulobacter COG0772 D LFTS_01755 47.2970513730092 -0.391032158413238 0.339298535141061 -1.15247228594921 0.249127051783047 0.425071963440395 510 Ni%2CFe-hydrogenase III small subunit NA K15832 NA Energy metabolism 00190 Oxidative phosphorylation COG3260 C LFTS_00234 258.639107858948 -0.221030392839078 0.192113937663005 -1.1505172166467 0.249930907292789 0.426151053175497 303 flagellar biosynthesis protein NA K04061 NA Nucleotide metabolism 00230 Purine metabolism COG2257 U LFTS_01499 558.321632932777 0.189594876836387 0.165262503434878 1.14723468963482 0.251284638137383 0.428165600006535 942 Tetratricopeptide repeat-containing protein NA K03353 Cell growth and death; Endocrine system; Folding, sorting and degradation; Infectious diseases Folding, sorting and degradation 04120 Ubiquitin mediated proteolysis NA LFTS_01466 8.1443002731101 -0.497379183372701 0.433914528226772 -1.14626072882437 0.251687286878869 0.428308534227474 615 hypothetical protein NA NA NA NA NA NA NA LFTS_00323 272.574208280337 0.245813695875959 0.214460002683938 1.14619832509388 0.25171310076683 0.428308534227474 270 hypothetical protein NA NA NA NA NA NA NA LFTS_02534 1422.92017326837 0.168987894063471 0.147612302227807 1.144809013294 0.252288280827011 0.428993615688063 951 quinolinate synthetase NA K03517 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00760 Nicotinate and nicotinamide metabolism COG0379 H LFTS_00333 3070.25561860362 -0.175594966831016 0.153529563164597 -1.14372087832207 0.252739411935895 0.429466970657987 861 Regulator of protease activity HflC%2C stomatin/prohibitin superfamily NA K04087 NA Folding, sorting and degradation 03050 Proteasome COG0330 O LFTS_02156 475.573703648658 -0.172204141614517 0.150730661597648 -1.14246258716882 0.253261788734926 0.430020054646816 1149 hypothetical protein NA K06076 NA Translation 03008 Ribosome biogenesis in eukaryotes COG2067 I LFTS_01149 1710.58027615247 -0.195581079033464 0.171246317039595 -1.14210385609778 0.253410852798707 0.430020054646816 873 Nucleotidyl transferase AbiEii toxin%2C Type IV TA system NA K09144 NA Infectious diseases 05132 Salmonella infection COG2253 V LFTS_01486 498.974824929334 0.202236008461662 0.177456928566116 1.13963433321971 0.254438675357159 0.431469677310981 261 (2Fe-2S) ferredoxin NA K05587 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG1894 C LFTS_00179 700.534797480722 -0.191071552779544 0.167830831206799 -1.13847706887722 0.25492132880283 0.431993471986254 345 Rhodanese-related sulfurtransferase NA K02439 Energy metabolism Energy metabolism 00920 Sulfur metabolism COG0607 P LFTS_00528 116.249123621562 -0.267414381747975 0.235252514124437 -1.13671211014785 0.255658655111485 0.432947831476261 1320 Glycosyltransferase involved in cell wall bisynthesis Extracellular polysaccharide production and export K08256 NA Cell motility 02040 Flagellar assembly COG0438 M LFTS_00899 1141.95265843984 -0.147512641558317 0.129977312221804 -1.13491069354157 0.256412738950494 0.433727322615576 1344 TolB protein NA K03641 NA Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG0823 U LFTS_01753 32.128371281114 -0.380897585832557 0.335657914654201 -1.13477909860985 0.256467885858768 0.433727322615576 1458 hydrogenase-4 component F NA K12141 NA Amino acid metabolism 00260 Glycine, serine and threonine metabolism COG0651 CP LFTS_02455 5978.94673625553 0.136742622166606 0.121512863600856 1.12533453754967 0.260447299561381 0.440157706804618 306 Pyruvate:ferredoxin oxidoreductase%2C delta subunit Reductive TCA cycle carbon dioxide fixation K00171 Carbohydrate metabolism; Overview; Energy metabolism; Xenobiotics biodegradation and metabolism Overview 01200 Carbon metabolism COG1144 C LFTS_01200 29.6605473524916 -0.401642852933162 0.358343558956842 -1.12083179087233 0.262359469239653 0.443088071012077 339 nitrogen regulatory protein P-II family protein Nitrate/nitrite regulation K02589 NA Translation 00970 Aminoacyl-tRNA biosynthesis COG0347 TE LFTS_01160 20.2082211763943 0.442088284283515 0.395900202008902 1.11666597299077 0.264137171962001 0.445787514933833 1503 Molybdate transporter of MFS superfamily protein NA NA NA NA NA NA NA LFTS_01177 3.88262911334038 -0.468309125095043 0.419570089001146 -1.11616422946147 0.264351842914472 0.445847138049781 306 nitrogen fixation protein NifZ Nitrogenase genes K02597 NA Carbohydrate metabolism 00051 Fructose and mannose metabolism NA LFTS_00153 697.495776210307 0.164479900212654 0.147819239247137 1.11270969225908 0.265833131531234 0.448041467787557 1656 peptide chain release factor 3 NA K02837 NA Replication and repair 03440 Homologous recombination COG0480 J LFTS_00686 2667.89679975472 0.167529428060393 0.150871085649375 1.11041441333385 0.266820490086767 0.449400906745056 2727 protein translocase subunit secA NA K03070 Cellular community - prokaryotes; Folding, sorting and degradation; Membrane transport Folding, sorting and degradation 03060 Protein export COG0653 U LFTS_01021 218.820251938501 0.241082388977212 0.217439289385804 1.10873425708018 0.267544838961918 0.450315822382755 1344 exodeoxyribonuclease-5 NA K01144 NA Metabolism of other amino acids 00410 beta-Alanine metabolism NA LFTS_00284 82.751596940256 0.291159813112627 0.262830948014545 1.10778359744955 0.267955285556803 0.450701515489995 498 hypothetical protein NA NA NA NA NA NA NA LFTS_00403 2938.72444608296 -0.15952533589325 0.144454054012627 -1.10433270276586 0.269448841728142 0.452907248503152 1329 seryl-tRNA synthetase NA K01875 Translation Translation 00970 Aminoacyl-tRNA biosynthesis COG0172 J LFTS_01608 1158.74992719827 -0.144045482984967 0.130632255810414 -1.10267928921032 0.270166463881652 0.453806641357965 696 hypothetical protein NA NA NA NA NA NA NA LFTS_01290 2516.20445033521 0.200652658604801 0.182602751688059 1.09884794588187 0.271834394965032 0.456300003972364 2346 Beta-barrel assembly machine subunit BamA NA K07277 NA Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG4775 M LFTS_00056 601.660871489965 0.160362347750956 0.146307409368481 1.09606443339501 0.27305057798726 0.45795109038648 1737 peptide/nickel transport system substrate-binding protein NA K02035 Cellular community - prokaryotes Cellular community - prokaryotes 02024 Quorum sensing COG0747 E LFTS_01351 226.558973721292 -0.236134974393228 0.21549998255875 -1.09575403018352 0.273186430829907 0.45795109038648 426 Cytochrome C oxidase%2C cbb3-type%2C subunit III Cytochrome cbb3 oxidase K00406 Energy metabolism; Signal transduction Energy metabolism 00190 Oxidative phosphorylation COG2010 C LFTS_00124 466.333414808815 0.166696484001986 0.152433837468967 1.0935661449573 0.274145304216223 0.45895003006622 486 hypothetical protein NA K09928 NA Signal transduction 04014 Ras signaling pathway COG3216 S LFTS_01420 138.16073503437 0.246417246123711 0.225336586399413 1.09355187304973 0.274151566632477 0.45895003006622 177 hypothetical protein NA NA NA NA NA NA NA LFTS_01872 222.801825297953 0.198523363474645 0.182227967736259 1.08942313268823 0.275967334892719 0.461499918315502 621 glycerol-3-phosphate acyltransferase PlsY NA K08591 Lipid metabolism Lipid metabolism 00561 Glycerolipid metabolism COG0344 I LFTS_00851 57136.3596060233 -0.191118860081607 0.175459992542563 -1.08924466091748 0.276046009064824 0.461499918315502 1626 chaperonin GroEL Chaperones K04077 Aging; Endocrine and metabolic diseases; Folding, sorting and degradation; Infectious diseases Folding, sorting and degradation 03018 RNA degradation COG0459 O LFTS_01725 40.4009911127163 -0.365778667451374 0.336094475279742 -1.08832097625801 0.276453433457769 0.461870454016138 315 Phage integrase family protein NA K03733 NA Replication and repair 03030 DNA replication COG0582 LX LFTS_02298 542.636445187087 0.165229828237287 0.152101968503085 1.08630959785334 0.277342042130843 0.463043866176813 1674 2-octaprenylphenol hydroxylase NA K03688 NA Membrane transport 02010 ABC transporters COG0661 HT LFTS_00733 1168.0492699682 0.169908032102239 0.156478312283594 1.08582479976079 0.277556512195342 0.463090932427934 2874 diguanylate cyclase (GGDEF) domain-containing protein NA K14051 Cellular community - prokaryotes Cellular community - prokaryotes 02024 Quorum sensing COG2199;COG2200;COG2202 T LFTS_00826 872.925872233463 -0.157573991617017 0.14521383174851 -1.08511695972538 0.277869856708159 0.463302792606628 2142 ATP-dependent DNA helicase RecG NA K03655 Replication and repair Replication and repair 03440 Homologous recombination COG1200 L LFTS_01807 1078.17057527176 0.197031741536543 0.18172358342723 1.08423869825043 0.278258977577497 0.463632617439112 444 Transposase (or an inactivated derivative) NA K07493 NA Overview 01200 Carbon metabolism COG3328 X LFTS_02159 2481.2543086675 -0.14634670838745 0.135027500911258 -1.08382890448095 0.278440666869104 0.463632617439112 231 acyl carrier protein NA K02078 Lipid metabolism Lipid metabolism 00061 Fatty acid biosynthesis COG0236 IQ LFTS_01556 707.484016259346 -0.160841860110022 0.148660373902833 -1.08194171646004 0.279278426778966 0.464716311226579 1416 fumarase%2C class II Reductive TCA cycle carbon dioxide fixation K01679 Carbohydrate metabolism; Overview; Cancers; Energy metabolism Overview 01200 Carbon metabolism COG0114 C LFTS_01456 376.783112062121 -0.216748444073502 0.20043127202886 -1.0814103102748 0.279514637389171 0.464798253210353 426 transcriptional regulator%2C BadM/Rrf2 family NA K13643 NA Signal transduction 02020 Two-component system COG1959 K LFTS_00860 544.832462064043 0.186448010133454 0.17289108468154 1.07841309733747 0.280849444642007 0.466705694772746 735 hypothetical protein NA NA NA NA NA NA NA LFTS_00317 257.148376198097 0.196282741391698 0.182376019369982 1.07625301873435 0.281814113905022 0.467995916611814 762 PLD-like domain-containing protein NA K06131 Lipid metabolism Lipid metabolism 00564 Glycerophospholipid metabolism COG1502 I LFTS_00241 1760.1433394511 0.167687090643622 0.15587572324387 1.07577425883871 0.282028227177038 0.46803883361957 1185 LL-diaminopimelate aminotransferase apoenzyme NA K08969 Amino acid metabolism Amino acid metabolism 00270 Cysteine and methionine metabolism COG0436 E LFTS_00861 444.912336032323 -0.201894603229284 0.187943025693079 -1.07423301548304 0.282718258502836 0.468870974408305 543 phosphatidylglycerophosphatase A NA K01095 Lipid metabolism Lipid metabolism 00564 Glycerophospholipid metabolism COG1267 I LFTS_00997 36.0385463757889 -0.348784580424698 0.325557225063238 -1.07134645946484 0.2840136771099 0.470528258204143 531 hypothetical protein NA NA NA NA NA NA NA LFTS_01945 578.962968052831 0.238118483554152 0.222298999761858 1.07116309029389 0.284096104410466 0.470528258204143 918 NAD+ kinase NA K00858 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00760 Nicotinate and nicotinamide metabolism COG0061 F LFTS_02203 153.916726145723 -0.226850301571295 0.211907517840672 -1.07051559039948 0.284387295242958 0.470696948051927 582 hypothetical protein NA NA NA NA NA NA NA LFTS_00778 424.12211974474 0.163978448437432 0.153582709448054 1.06768821195262 0.285661177580158 0.472490810022802 1176 SAM-dependent methyltransferase NA K06969 NA Translation 03010 Ribosome COG1092 J LFTS_00465 197.689964833854 0.217267952106071 0.203913216593272 1.06549225075212 0.286653230495963 0.473816443492662 447 hypothetical protein NA K06929 NA Lipid metabolism 00564 Glycerophospholipid metabolism COG1832 R LFTS_01086 9.91898406418549 -0.455858749648998 0.428421810110537 -1.06404188323508 0.287309726409385 0.474507602597505 333 hypothetical protein NA NA NA NA NA NA NA LFTS_01839 126.462886968118 -0.268255076239384 0.252184518475117 -1.06372539385622 0.287453117261401 0.474507602597505 759 Regulator of protease activity HflC%2C stomatin/prohibitin superfamily NA K15932 Metabolism of terpenoids and polyketides Metabolism of terpenoids and polyketides 01057 Biosynthesis of type II polyketide products NA LFTS_00523 96.8376227331301 -0.272202928733853 0.256003579562746 -1.06327782290691 0.287655979249046 0.474527381826893 789 methyltransferase%2C FkbM family NA NA NA NA NA NA NA LFTS_01575 1618.26820823889 -0.126831084178249 0.119935704822454 -1.05749229861118 0.290286967585901 0.478550000940683 2220 glycyl-tRNA synthetase beta chain NA K01879 Translation Translation 00970 Aminoacyl-tRNA biosynthesis COG0751 J LFTS_01273 27.0043629398608 -0.383110191772064 0.362480182856086 -1.0569134807686 0.290551075423407 0.478667974488132 159 Transposase IS200 like protein NA K07491 NA Translation 03010 Ribosome COG1943 X LFTS_00395 3133.27460535722 0.165673722664746 0.156859558505591 1.05619143801709 0.290880761675148 0.478893757300938 1431 zinc protease NA K07263 NA Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG0612 R LFTS_02075 454.287439783748 -0.167744345799024 0.159213396806737 -1.0535818540612 0.292074400605823 0.480540674987476 834 putative membrane-anchored protein NA NA NA NA NA NA NA LFTS_00467 724.273382977387 0.153172075176285 0.145586798885506 1.05210140169882 0.292753029126982 0.481338644450844 594 hypothetical protein NA NA NA NA NA NA NA LFTS_00822 975.921915942963 0.164336956628613 0.15652512677894 1.04990783275778 0.293760490008128 0.482675861308795 1377 ubiquinol-cytochrome c reductase cytochrome b subunit Cytochrome b/c1 K00412 Circulatory system; Endocrine and metabolic diseases; Energy metabolism; Signal transduction; Neurodegenerative diseases Energy metabolism 00190 Oxidative phosphorylation COG1290 C LFTS_02283 773.35131088797 0.170465519674105 0.162755838788611 1.04736961170104 0.294929141547301 0.484275988036057 1260 hypothetical protein NA NA NA NA NA NA NA LFTS_01333 976.391227878597 -0.141210646566268 0.135225399425596 -1.04426126427502 0.296364529166456 0.486311696044759 1278 phosphoribosylamine--glycine ligase NA K01945 Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0151 F LFTS_01702 304.027660751072 0.177353172755162 0.169925612211883 1.04371065930907 0.29661927668113 0.486408655560218 1245 2-polyprenyl-6-methoxyphenol hydroxylase NA K05712 Amino acid metabolism; Overview Overview 01220 Degradation of aromatic compounds COG0654 HC LFTS_01563 1092.97473407371 0.136718757825912 0.131049527470121 1.04326021211396 0.296827793265007 0.486429725812002 1434 DNA recombination protein RmuC NA K09760 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG1322 L LFTS_00436 70.1008568404276 -0.282922117198997 0.271915874524362 -1.04047664629322 0.298118508535788 0.488223064703536 216 putative nuclease of the RNAse H fold%2C HicB family NA NA NA NA NA NA NA LFTS_01498 71.7598791211866 -0.272416687949088 0.261934547819339 -1.0400181656716 0.298331461079483 0.488250172642262 177 Aldo/keto reductase family protein NA K05882 NA Folding, sorting and degradation 04120 Ubiquitin mediated proteolysis NA LFTS_02184 761.85614096576 0.222955662454129 0.214608377830035 1.03889542760863 0.298853373144303 0.488635311341683 1458 TldD protein NA K03568 NA Metabolism of terpenoids and polyketides 00906 Carotenoid biosynthesis COG0312 R LFTS_02162 711.600858363694 0.149228130142148 0.143672815257211 1.03866643021501 0.298959898853862 0.488635311341683 1026 3-oxoacyl-[acyl-carrier-protein] synthase-3 NA K00648 Overview; Lipid metabolism Overview 01212 Fatty acid metabolism COG0332 I LFTS_02300 102.169928058592 -0.25071283536867 0.241626127055801 -1.03760648082055 0.29945329946649 0.48912017245315 678 undecaprenyl-diphosphatase NA K01096 Lipid metabolism Lipid metabolism 00564 Glycerophospholipid metabolism COG0671 I LFTS_00655 1041.61748261657 0.195065853663673 0.188313346306854 1.03585782680435 0.300268475037748 0.49012963161119 1362 two-component system%2C OmpR family%2C phosphate regulon sensor histidine kinase PhoR NA K07652 Signal transduction Signal transduction 02020 Two-component system COG5002 T LFTS_00035 468.549863500141 0.197461262964466 0.190761093058867 1.03512335664554 0.300611306044168 0.490367261696721 1158 S-adenosylmethionine:tRNA ribosyltransferase-isomerase NA K07568 NA Cellular community - prokaryotes 02024 Quorum sensing COG0809 J LFTS_00097 712.353198981967 -0.190088204064659 0.183731927954219 -1.034595381332 0.300857911871051 0.490447717318972 1011 peptide/nickel transport system ATP-binding protein NA K02031 Cellular community - prokaryotes Cellular community - prokaryotes 02024 Quorum sensing COG0444;COG1123 EPO LFTS_01710 378.752196725496 -0.184245634707928 0.179474904677138 -1.02658159946858 0.304617522093129 0.496251087761152 1491 Tetratricopeptide repeat protein NA K12284 NA Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism NA LFTS_02235 488.544850015072 0.150229029237371 0.146421679284473 1.02600263821248 0.304890340514753 0.496370259672348 1242 HD domain-containing protein NA K07814 NA Carbohydrate metabolism 00500 Starch and sucrose metabolism COG3437 T LFTS_01533 1129.16760467497 0.175462368688022 0.171205073106964 1.02486664386632 0.305426115447289 0.496917096205471 1098 chorismate mutase / prephenate dehydratase NA K14170 Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG1605;COG0077 E LFTS_01043 23.7323028447579 0.385712232696423 0.376557047695365 1.02431287651391 0.305687517908517 0.497017115448379 396 hypothetical protein NA K15151 NA Folding, sorting and degradation 03018 RNA degradation NA LFTS_01142 30.7552120334461 -0.386424180956886 0.378227039030286 -1.02167254342158 0.30693591037777 0.498720701437344 1722 hypothetical protein NA NA NA NA NA NA NA LFTS_02470 478.696365248691 0.154107796320096 0.151046393890164 1.02026796106207 0.307601393853332 0.499369292998793 762 mannose-1-phosphate guanylyltransferase / phosphomannomutase NA K00966 Carbohydrate metabolism Carbohydrate metabolism 00051 Fructose and mannose metabolism COG1208 JM LFTS_01255 103.912956459661 0.22993459536592 0.225483631794261 1.01973963048334 0.307851961006223 0.499369292998793 1182 serine/threonine-protein kinase HipA NA K07154 NA Overview 01210 2-Oxocarboxylic acid metabolism COG3550 T LFTS_00492 693.248079903231 -0.15443635574289 0.151530309207067 -1.01917798855575 0.308118474539282 0.499369292998793 951 Sel1 repeat-containing protein Extracellular polysaccharide production and export K07126 NA Translation 03010 Ribosome COG0790 T LFTS_01398 303.305619177992 -0.182863470313409 0.179429962390033 -1.01913564422375 0.308138574199577 0.499369292998793 1533 MFS transporter%2C DHA2 family%2C multidrug resistance protein NA K03446 NA Membrane transport 03070 Bacterial secretion system COG0477 GEPR LFTS_00627 1485.88087641559 -0.161099331544276 0.158161279677818 -1.01857630307774 0.308404159073778 0.499463773375076 1071 uroporphyrinogen decarboxylase NA K01599 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0407 H LFTS_01399 194.361717432031 -0.245417536992294 0.241038636718578 -1.01816679820849 0.308598695053949 0.499463773375076 333 hypothetical protein NA NA NA NA NA NA NA LFTS_01054 159.609321781775 0.206573119300863 0.202992220983662 1.01764056917969 0.308848800153337 0.499543342343003 1623 general secretion pathway protein D NA K02453 Cellular community - prokaryotes; Membrane transport Membrane transport 03070 Bacterial secretion system COG1450 U LFTS_02487 282.23119384269 -0.193045381286809 0.189960781248032 -1.01623808882292 0.309516022592387 0.500102607385092 306 hypothetical protein NA K07090 NA Overview 01200 Carbon metabolism COG0730 S LFTS_01926 132.868258176875 0.256577183823099 0.252519645998071 1.01606820653098 0.309596907789886 0.500102607385092 1215 putative arabinose efflux permease%2C MFS family NA K03535 NA Signal transduction 02020 Two-component system COG0477 GEPR LFTS_00788 994.615848942887 -0.131969173805183 0.130046515834932 -1.01478438663202 0.310208617950402 0.500509939024122 873 shikimate dehydrogenase NA K00014 Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG0169 E LFTS_02230 46.3256659458734 0.338598012067074 0.333694716612491 1.01469395591383 0.310251736136835 0.500509939024122 285 hypothetical protein NA NA NA NA NA NA NA LFTS_00638 44.5943918394039 0.314254330137403 0.310093712869836 1.01341728998328 0.310860884260765 0.501167417815993 408 PaaX-like protein NA K02616 NA Replication and repair 03030 DNA replication COG3327 K LFTS_01268 428.090464402777 -0.175599297523694 0.17345029141185 -1.01238975209757 0.311351736279302 0.501633451970411 489 hypothetical protein NA K06142 NA Membrane transport 03070 Bacterial secretion system COG2825 MO LFTS_01251 27.7566478355358 -0.379260126093097 0.375914192473953 -1.00890079088827 0.313022215877849 0.503998205098661 681 WYL domain-containing protein NA K13572 NA Overview 01210 2-Oxocarboxylic acid metabolism COG2378 K LFTS_02431 685.637696937646 -0.16161424225343 0.160617594203465 -1.0062050988555 0.314316919931381 0.505755251099944 309 nitrite reductase (NADH) small subunit Nitrite uptake & assimilation to ammonia K00363 Energy metabolism Energy metabolism 00910 Nitrogen metabolism COG2146 PQ LFTS_01815 369.143115710793 -0.231797114921335 0.230704987662729 -1.00473386930066 0.315025014721202 0.506366639974543 1254 Glycosyltransferase involved in cell wall bisynthesis Lipopolysaccharide synthesis K13668 NA Membrane transport 02010 ABC transporters COG0438 M LFTS_02154 967.771129082403 0.128720272172721 0.128134779145627 1.00456935291884 0.315104260676033 0.506366639974543 1053 phosphoribosylformylglycinamidine cyclo-ligase NA K01933 Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0150 F LFTS_00449 449.367757356698 -0.172283000919759 0.171612740508369 -1.00390565647635 0.315424089857262 0.506553157225551 1599 Signal transduction histidine kinase NA K00936 NA Nucleotide metabolism 00230 Purine metabolism NA LFTS_00840 692.048678617339 0.169856178618074 0.169571082051213 1.00168128057811 0.316497550483091 0.507648749200893 297 integration host factor subunit beta NA K05788 NA Folding, sorting and degradation 03060 Protein export COG0776 L LFTS_01414 441.875490740691 0.173166347628133 0.172982672026041 1.00106181503581 0.316796924366 0.507648749200893 1221 hypothetical protein NA NA NA NA NA NA NA LFTS_01581 3878.76774359364 -0.175140202359628 0.17497593509992 -1.00093879915323 0.31685639729972 0.507648749200893 411 CBS domain-containing protein NA K07182 NA Glycan biosynthesis and metabolism 00550 Peptidoglycan biosynthesis COG2905 T LFTS_00100 810.672469760429 -0.1634884615391 0.163357641434103 -1.00080082023619 0.316923112936358 0.507648749200893 1059 hypothetical protein NA K01186 Lipid metabolism; Glycan biosynthesis and metabolism; Transport and catabolism Lipid metabolism 00600 Sphingolipid metabolism COG4409 GM LFTS_02180 652.832649170319 0.149126441536783 0.149080410089758 1.00030876925411 0.317161104691777 0.507702837259341 1386 DNA repair protein RadA/Sms NA K04485 NA Amino acid metabolism 00330 Arginine and proline metabolism COG1066 O LFTS_02155 526.703157346131 0.195164016371564 0.195289585705205 0.999357009575361 0.317621777620299 0.507814315430931 1065 hypothetical protein NA NA NA NA NA NA NA LFTS_00720 2024.21441450214 -0.140683477710148 0.140825626022287 -0.998990607631901 0.317799241205565 0.507814315430931 1029 type II secretion system protein N NA K07289 NA Metabolism of cofactors and vitamins 00760 Nicotinate and nicotinamide metabolism COG2982 M LFTS_00953 547.340113609164 0.194218173865771 0.194432216891952 0.998899138066713 0.317843553825635 0.507814315430931 540 adenosylcobinamide kinase /adenosylcobinamide-phosphate guanylyltransferase NA K02231 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG2087 H LFTS_01580 615.935537683429 -0.151285991250383 0.151639000779509 -0.997672039994252 0.318438415535823 0.508437958267217 1143 8-amino-7-oxononanoate synthase NA K00652 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00780 Biotin metabolism COG0156 H LFTS_01188 44.2764944352926 -0.302636621006347 0.303794659862111 -0.996188086860085 0.319158766622531 0.509261035830302 1191 homocitrate synthase NifV NA K02594 Carbohydrate metabolism Carbohydrate metabolism 00620 Pyruvate metabolism COG0119 E LFTS_00745 59.9744511406287 -0.283796535599973 0.28533122825643 -0.994621364559939 0.319920452602952 0.510148970603553 618 repressor LexA NA K01356 NA Overview 01200 Carbon metabolism COG1974 KT LFTS_00807 1047.58388585974 -0.173340514428188 0.175306058391887 -0.98878792905545 0.322766911353004 0.513964033086185 978 tRNA pseudouridine55 synthase NA K03177 NA Translation 03010 Ribosome COG0130 J LFTS_01129 45.3050027333566 0.32589529115246 0.329602768374271 0.988751680575688 0.322784650488197 0.513964033086185 495 hypothetical protein NA NA NA NA NA NA NA LFTS_02434 717.904186411808 -0.192202246314031 0.194449961693164 -0.988440648897222 0.322936888052806 0.513964033086185 696 NAD(P)-dependent dehydrogenase%2C short-chain alcohol dehydrogenase family NA NA NA NA NA NA NA LFTS_01607 2959.45090944008 0.116337447880321 0.117749852575479 0.988005040649607 0.323150179553188 0.513964033086185 2196 hypothetical protein NA K12284 NA Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism NA LFTS_00589 534.307938705789 -0.18216840913791 0.184476255399312 -0.987489738143232 0.323402611151362 0.513964033086185 543 hypothetical protein Quorum sensing K07782 Cellular community - prokaryotes; Signal transduction Signal transduction 02020 Two-component system COG2771;COG2197 KTK LFTS_00593 291.757863193775 0.174021404400695 0.176280959108681 0.987182082969077 0.323553383660451 0.513964033086185 276 hypothetical protein NA K00127 Carbohydrate metabolism; Energy metabolism; Overview Overview 01200 Carbon metabolism COG2864 C LFTS_01030 123.958489786257 0.220100970020746 0.22312551836325 0.986444632757872 0.323914972195135 0.514204084682582 663 Uracil DNA glycosylase superfamily protein NA K02334 NA Overview 01210 2-Oxocarboxylic acid metabolism COG1573 L LFTS_01511 3375.02607922664 0.162663482603132 0.165027201180873 0.985676794123473 0.324291740484337 0.514204084682582 1608 D-3-phosphoglycerate dehydrogenase NA K00058 Energy metabolism; Overview; Amino acid metabolism Overview 01200 Carbon metabolism COG0111 HR LFTS_02260 1381.107515352 0.164141932595185 0.166538590180858 0.985608995590328 0.324325022036319 0.514204084682582 198 SSU ribosomal protein S21P NA K02970 Translation Translation 03010 Ribosome COG0828 J LFTS_02095 1065.16388949751 0.144775272051802 0.147074780422422 0.984365039580438 0.324936061071121 0.514844517414153 441 hypothetical protein NA NA NA NA NA NA NA LFTS_01879 478.306370272366 0.16241446282352 0.165318462589132 0.982433905323515 0.325886129667012 0.516020967103307 1059 D-beta-D-heptose 7-phosphate kinase / D-beta-D-heptose 1-phosphate adenosyltransferase NA K03272 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG2870 M LFTS_01659 1361.47433941493 -0.178555646875726 0.182179326895204 -0.980109268810932 0.327032184384155 0.517506053710382 306 small subunit ribosomal protein S10 NA K02946 Translation Translation 03010 Ribosome COG0051 J LFTS_01567 1387.26910786854 -0.216933781932497 0.221536965062523 -0.979221602459315 0.327470497006477 0.517870009897011 666 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like protein NA K02609 Amino acid metabolism Amino acid metabolism 00360 Phenylalanine metabolism COG3396 Q LFTS_01950 2202.7994044424 0.138721037768433 0.142536581843936 0.973231124065536 0.330438445274625 0.522231389035421 795 tryptophan synthase%2C alpha chain NA K01695 Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG0159 E LFTS_00522 1.84611811949931 -0.34307769660954 0.352706892486399 -0.972699155922418 0.330702844894714 0.522317199751117 147 hypothetical protein NA NA NA NA NA NA NA LFTS_01859 175.778683917922 0.207345111645564 0.213590405481681 0.970760419588922 0.331667596740606 0.523508346347395 795 3%2C4-dihydroxyphenylacetate 2%2C3-dioxygenase NA K15777 Biosynthesis of other secondary metabolites Biosynthesis of other secondary metabolites 00965 Betalain biosynthesis NA LFTS_01882 355.27226970904 0.176443585812116 0.18190930036458 0.969953627761141 0.332069607135378 0.523810306686898 1980 Glucoamylase (glucan-1%2C4-alpha-glucosidase)%2C GH15 family NA K01178 Carbohydrate metabolism Carbohydrate metabolism 00500 Starch and sucrose metabolism COG3387 G LFTS_00110 74.0844564792195 0.29658061788749 0.306030545085514 0.969120967335521 0.332484837419028 0.524016450273479 645 putative amidophosphoribosyltransferases NA K02242 NA Glycan biosynthesis and metabolism 00514 Other types of O-glycan biosynthesis COG1040 R LFTS_00614 791.003989084078 0.188278739596507 0.194332922979567 0.968846331901796 0.332621865861444 0.524016450273479 600 hypothetical protein NA NA NA NA NA NA NA LFTS_00367 657.717447167116 -0.168364877465648 0.173873354572562 -0.968319026682061 0.332885065279601 0.524098969148251 1275 HD domain-containing protein NA K07814 NA Carbohydrate metabolism 00500 Starch and sucrose metabolism COG3437 T LFTS_01619 1457.08887617338 -0.134428417272036 0.139133429582105 -0.966183451926684 0.333952391831072 0.525446611450661 3213 heavy metal efflux pump%2C CzcA family Cadmium/cobalt/zinc resistance K03296 NA Nucleotide metabolism 00230 Purine metabolism COG0841 V LFTS_00976 148.955867887984 -0.207496093497556 0.214865882505835 -0.96570051549213 0.334194061485261 0.525494267458798 1026 hypothetical protein NA K11435 NA Membrane transport 03070 Bacterial secretion system NA LFTS_00656 533.182006192968 -0.151315239821203 0.156768835799281 -0.96521249934483 0.334438387633746 0.525546037710173 972 UDP-galactose 4-epimerase Extracellular polysaccharide production and export K01784 Carbohydrate metabolism Carbohydrate metabolism 00052 Galactose metabolism COG1087 M LFTS_00625 75.0372080445176 -0.260151777917503 0.269984346935576 -0.963580966342398 0.335256053236591 0.52642500390153 774 putative membrane protein NA K08977 NA Amino acid metabolism 00340 Histidine metabolism NA LFTS_01280 198.268305218417 -0.196050361932153 0.203529740268825 -0.963251668641681 0.335421241423984 0.52642500390153 489 inner membrane protein NA K07038 NA Amino acid metabolism 00270 Cysteine and methionine metabolism COG1988 R LFTS_01564 378.739591472455 0.174304002978789 0.181106110425917 0.962441314480603 0.33582796889233 0.526730807991377 339 putative membrane protein Extracellular polysaccharide production and export K08972 NA Translation 03010 Ribosome COG1950 S LFTS_00723 1279.77322616764 -0.134934905587655 0.140412822948306 -0.960987057694382 0.336558675339568 0.527383733457246 1716 type II secretion system protein E (GspE) NA K02454 Cellular community - prokaryotes; Membrane transport Membrane transport 03070 Bacterial secretion system COG2804 NUW LFTS_01233 458.261889930402 -0.172532177196623 0.179613539151486 -0.960574453416395 0.336766178752134 0.527383733457246 264 BrnA antitoxin of type II toxin-antitoxin system NA NA NA NA NA NA NA LFTS_01750 47.8870071336664 -0.314910910946526 0.327913723655427 -0.960346848055179 0.336880679296101 0.527383733457246 2061 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter%2C MnhD subunit NA K12137 NA Amino acid metabolism 00260 Glycine, serine and threonine metabolism COG0651 CP LFTS_02438 13999.7972181379 -0.18134161607538 0.189335082603475 -0.957781376709589 0.338173011972563 0.529073699033223 276 DNA-binding protein HU-beta NA K03530 NA Energy metabolism 00190 Oxidative phosphorylation COG0776 L LFTS_01076 43.8735187389706 0.302733335631423 0.316930840356882 0.955203145552288 0.339474975416886 0.530776596783887 1134 Competence protein ComGC NA NA NA NA NA NA NA LFTS_01719 1012.68419930288 0.132768269585601 0.139193872427078 0.953837027956508 0.34016614310339 0.531522961505359 1389 oxygen-dependent protoporphyrinogen oxidase NA K00231 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG1232 H LFTS_01812 267.938530393333 -0.218302969284109 0.229148859880964 -0.952668799650632 0.340757906386301 0.531814742063356 708 lipopolysaccharide transport system ATP-binding protein Lipopolysaccharide synthesis K09691 Membrane transport Membrane transport 02010 ABC transporters COG1134 GM LFTS_01011 190.558677209535 0.200784318264367 0.21076979508442 0.952623776969307 0.340780725706728 0.531814742063356 1299 DNA repair protein radc NA K03630 NA Signal transduction 02020 Two-component system COG2003 L LFTS_02400 1182.472541715 0.134048083731624 0.140815652008691 0.951940226952551 0.341127296799248 0.532021618471098 843 protein NrfD NA NA NA NA NA NA NA LFTS_01760 135.344068505636 -0.211482105849584 0.222839385654463 -0.949033786053917 0.342603428739127 0.533988792379606 279 hypothetical protein NA NA NA NA NA NA NA LFTS_00527 28.4742251884864 -0.33410033847429 0.352332752871128 -0.948252286373423 0.343001034745308 0.534090176606378 159 hypothetical protein NA NA NA NA NA NA NA LFTS_01570 246.50907995221 -0.177031157064059 0.186729616167708 -0.948061484285715 0.34309815448125 0.534090176606378 540 hypothetical protein NA NA NA NA NA NA NA LFTS_02286 587.431159719669 0.155907294487699 0.164816357813121 0.945945515095509 0.344176376890094 0.535299745407903 753 phosphate ABC transporter ATP-binding protein%2C PhoT family NA K02036 Membrane transport Membrane transport 02010 ABC transporters COG1117 P LFTS_00508 88.4319992193565 -0.250781540190221 0.265190369005396 -0.945666093119386 0.344318921846841 0.535299745407903 306 hypothetical protein NA NA NA NA NA NA NA LFTS_01472 45.486083994945 0.302862850632662 0.320458050079847 0.945093595112367 0.344611094929445 0.535299745407903 456 hypothetical protein NA K03048 Nucleotide metabolism; Transcription Nucleotide metabolism 00230 Purine metabolism COG3343 K LFTS_01808 421.607817479676 0.160759678063084 0.170143428053245 0.944848002079607 0.344736481254245 0.535299745407903 1038 heptosyltransferase-2 Lipopolysaccharide synthesis K02843 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG0859 M LFTS_01181 23.2184419164709 -0.360226622569769 0.381644631426342 -0.943879706164012 0.345231123535471 0.535689668112157 891 SIR2-like domain-containing protein NA NA NA NA NA NA NA LFTS_00738 48.446004932756 0.289523586549084 0.306866787342403 0.943482965545024 0.345433924317791 0.535689668112157 2268 cellulose synthase subunit Cellulose production NA NA NA NA NA NA LFTS_00515 226.663810831348 -0.197255006506354 0.209157840363429 -0.943091620011031 0.345634041694248 0.535689668112157 777 Hpt domain-containing protein Quorum sensing K10715 Cellular community - prokaryotes; Signal transduction Signal transduction 02020 Two-component system COG0642;COG0784 T LFTS_00397 55.5147740133257 -0.280507796389631 0.298331053902002 -0.940256780917533 0.347085862704966 0.537604644663268 1002 hypothetical protein NA K01163 NA Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG4866 S LFTS_00469 453.667646963696 0.14295551793945 0.152218097656555 0.939149287373148 0.347654101882952 0.538149500174981 897 NADH dehydrogenase NA K00329 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation NA LFTS_01104 64.3808913270189 0.256146391146433 0.273049479420643 0.938095145575538 0.348195516330363 0.538652180209884 1140 hypothetical protein NA K06871 NA Metabolism of cofactors and vitamins 00130 Ubiquinone and other terpenoid-quinone biosynthesis COG0641 O LFTS_02009 1473.70856188795 0.223591621537074 0.238649909751794 0.936902183493883 0.348808875941178 0.539142487316996 723 hypothetical protein NA K09857 NA Membrane transport 02060 Phosphotransferase system (PTS) COG3009 S LFTS_01047 103.889887115079 0.238653399886762 0.254798647682993 0.936635268895469 0.348946203577251 0.539142487316996 966 hypothetical protein NA NA NA NA NA NA NA LFTS_01119 65.6501038129935 0.26195433133168 0.280319201365255 0.934485864884991 0.350053324005189 0.540220180951421 1086 twitching motility protein PilT NA K02669 NA Replication and repair 03030 DNA replication COG2805 NW LFTS_02017 668.013319012032 -0.144819933900091 0.154980886836426 -0.934437380352201 0.3500783232151 0.540220180951421 615 outer membrane lipoprotein NA K07285 NA Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG3065 M LFTS_01072 15.6070938063795 -0.39659242970061 0.425199524070339 -0.932720775188364 0.350964155432523 0.541203902768112 723 hypothetical protein NA NA NA NA NA NA NA LFTS_02174 318.227067619761 0.156106319774645 0.167431619923221 0.932358653916327 0.351151204812938 0.541203902768112 858 undecaprenyl-diphosphatase NA K06153 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00550 Peptidoglycan biosynthesis COG1968 I LFTS_01588 1057.43048242964 -0.128381418167994 0.138350013243279 -0.927946554961616 0.353435293530055 0.544386703665252 1248 phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase NA K13038 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00770 Pantothenate and CoA biosynthesis COG0452 H LFTS_02078 1999.43872880004 -0.149076110440728 0.16127674049888 -0.924349723212339 0.355304262211042 0.546678707345209 1884 NADH-quinone oxidoreductase subunit F NADH dehydrogenase K00335 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG1894 C LFTS_00305 162.107422078624 -0.200318150612782 0.216739039820187 -0.924236587829181 0.355363150068326 0.546678707345209 912 oligopeptide transport system permease protein NA K15581 Cellular community - prokaryotes; Drug resistance; Membrane transport Membrane transport 02010 ABC transporters COG0601 EP LFTS_00118 345.478697585523 -0.153833611614487 0.166693224820347 -0.922854613798971 0.356082975416034 0.547447295537576 690 Tetratricopeptide repeat-containing protein NA K09667 Endocrine and metabolic diseases; Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00514 Other types of O-glycan biosynthesis NA LFTS_00004 1172.63572955924 0.16408928436612 0.178012817073819 0.921783538193628 0.356641495770332 0.54796709424292 2451 DNA gyrase subunit A NA K02469 NA Nucleotide metabolism 00230 Purine metabolism COG0188 L LFTS_01390 626.370743471115 -0.170657785979251 0.185523560950409 -0.919871228780846 0.357640055525879 0.549161938256538 918 fructose-bisphosphate aldolase NA K16305 Carbohydrate metabolism; Overview; Energy metabolism; Amino acid metabolism Overview 01200 Carbon metabolism COG1830 G LFTS_00414 1358.4953407979 -0.146785253316219 0.159768222166764 -0.918738728675382 0.358232247443551 0.549731708113992 483 hypothetical protein NA NA NA NA NA NA NA LFTS_00635 108.101815457908 -0.263313705192237 0.287209305879388 -0.916800743576234 0.359247062923753 0.550948919450001 147 hypothetical protein NA NA NA NA NA NA NA LFTS_01709 160.910822790824 -0.203233818941414 0.222560415128093 -0.913162472421003 0.361157097792037 0.553536710919238 558 TolB amino-terminal domain-containing protein NA K07337 NA Overview 01200 Carbon metabolism COG3417 M LFTS_00848 202.581113837678 0.176800587629776 0.193850815092147 0.912044592362087 0.361745243900679 0.554096535019771 1197 Septal ring factor EnvC%2C activator of murein hydrolases AmiA and AmiB NA K06194 NA Glycan biosynthesis and metabolism 00550 Peptidoglycan biosynthesis COG0739 M LFTS_00725 2389.38734434041 -0.122559271521295 0.134550179718891 -0.910881514817387 0.362357806423647 0.554693046040139 972 general secretion pathway protein C NA K02452 Cellular community - prokaryotes; Membrane transport Membrane transport 03070 Bacterial secretion system COG3031 U LFTS_00710 1227.82902628614 0.147871592456857 0.162434985799019 0.910343247358164 0.362641517607864 0.554785730937324 1041 chemotaxis protein CheZ Chemotaxis K03414 Cell motility Cell motility 02030 Bacterial chemotaxis COG3143 NT LFTS_01166 4.47704910755865 -0.3877116518893 0.426153172089976 -0.909794123995023 0.362931094035327 0.554887269232363 1434 nitrogenase molybdenum-iron protein NifN Nitrogenase genes K02592 NA Xenobiotics biodegradation and metabolism 00930 Caprolactam degradation COG2710 P LFTS_02245 342.497216324281 -0.163648500519466 0.180008802332247 -0.909113878872521 0.363290017279516 0.555094642259912 597 XTP/dITP diphosphohydrolase NA K02428 Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0127 F LFTS_01585 799.668997622396 0.126769365040336 0.139625081098068 0.907926885652425 0.363916851859099 0.555710868379436 285 hypothetical protein NA K09777 NA Nucleotide metabolism 00230 Purine metabolism COG2052 M LFTS_01077 40.6681987800285 0.311120615892647 0.343978142271555 0.904477865477369 0.365742066094616 0.557991011919503 1164 hypothetical protein NA K06871 NA Energy metabolism 00190 Oxidative phosphorylation COG0641 O LFTS_00462 821.788879562357 -0.18217623043876 0.201465023154835 -0.904257362325121 0.365858949890905 0.557991011919503 924 3-hydroxyisobutyrate dehydrogenase NA K00020 Amino acid metabolism Amino acid metabolism 00280 Valine, leucine and isoleucine degradation COG2084 I LFTS_02313 90.8695668146911 -0.226732356103551 0.251320032858649 -0.902165870044562 0.366968762103317 0.559340492083903 345 nitrogen regulatory protein P-II family protein Nitrate/nitrite regulation K04751 Signal transduction Signal transduction 02020 Two-component system COG0347 TE LFTS_00961 1162.52914000044 0.120236925358331 0.13337854931523 0.901471233385215 0.36733782209505 0.559433858932635 1017 putative oxidoreductase NA K05275 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00750 Vitamin B6 metabolism COG0667 R LFTS_01881 976.784253787819 0.12266240806659 0.136109542938172 0.901203585132236 0.367480085131534 0.559433858932635 1830 GTP-binding protein LepA NA K03596 Infectious diseases Infectious diseases 05134 Legionellosis COG0481 J LFTS_00719 436.274430235929 -0.146991909236045 0.163237129919051 -0.900480848376457 0.367864412745214 0.559676211802082 1359 hypothetical protein NA K02461 Cellular community - prokaryotes; Membrane transport Membrane transport 03070 Bacterial secretion system COG3297 U LFTS_00459 247.221296196291 -0.164918827358834 0.183779366210187 -0.897374012979333 0.369519374597003 0.561170650844027 2226 two-component system%2C OmpR family%2C sensor histidine kinase KdpD Role of potassium in the internal positive membrane potential K07646 Signal transduction Signal transduction 02020 Two-component system COG2205 T LFTS_01203 11.0744759030031 -0.384430541651005 0.428505449668812 -0.897142712999632 0.369642769257842 0.561170650844027 327 nitrogen regulatory protein P-II family protein Nitrate/nitrite regulation K02589 NA Energy metabolism 00910 Nitrogen metabolism COG0347 TE LFTS_00458 66.3268687279706 -0.277432092992287 0.309240843997749 -0.897139231046419 0.369644627017152 0.561170650844027 645 hypothetical protein NA NA NA NA NA NA NA LFTS_01363 300.24001473046 -0.154088435684621 0.171792994833565 -0.896942484959318 0.369749608239146 0.561170650844027 570 hypothetical protein NA K00573 NA Carbohydrate metabolism 00500 Starch and sucrose metabolism COG2518 O LFTS_00962 702.381446027977 0.131127842213066 0.146412747902878 0.895603996859946 0.370464300283981 0.561912294390469 804 alpha-ribazole phosphatase NA K15634 Energy metabolism; Overview; Amino acid metabolism; Carbohydrate metabolism Overview 01200 Carbon metabolism COG0406 G LFTS_02436 444.758648233084 0.16633426423151 0.18623485773267 0.893142488235333 0.371780872130514 0.563221999381698 3012 Multidrug efflux pump subunit AcrB NA K03296 NA Energy metabolism 00910 Nitrogen metabolism COG0841 V LFTS_02284 671.958799195519 0.140693945272182 0.157526882196239 0.893142448518166 0.371780893397171 0.563221999381698 819 thymidylate synthase (FAD) NA K03465 Nucleotide metabolism; Metabolism of cofactors and vitamins Nucleotide metabolism 00240 Pyrimidine metabolism COG1351 F LFTS_02458 8202.98685568579 0.165903377188166 0.185882728429785 0.89251636550425 0.372116224845747 0.563386683901661 1239 pyruvate ferredoxin oxidoreductase alpha subunit Reductive TCA cycle carbon dioxide fixation K00169 Carbohydrate metabolism; Overview; Energy metabolism; Xenobiotics biodegradation and metabolism Overview 01200 Carbon metabolism COG0674 C LFTS_02112 96.5494215243054 -0.384333212276585 0.431096908309696 -0.891523935496387 0.372648156575488 0.56384864105092 246 hypothetical protein NA NA NA NA NA NA NA LFTS_02227 515.655783175769 -0.150990184466821 0.169830120056001 -0.889065993812125 0.373967613616087 0.565500904774691 720 protein gp37 NA NA NA NA NA NA NA LFTS_01658 2144.88161100548 0.171053600962655 0.193125002699587 0.885714426260673 0.37577143249637 0.567883149657129 624 large subunit ribosomal protein L3 NA K02906 Translation Translation 03010 Ribosome COG0087 J LFTS_01052 630.292728572101 -0.16855010303728 0.190542427202609 -0.884580434456496 0.376382963042045 0.568461753415871 459 hypothetical protein NA K11581 NA Replication and repair 03030 DNA replication NA LFTS_01837 209.481841397687 -0.211860215540148 0.239738469267163 -0.883713891173855 0.376850679660685 0.568822580228575 528 DinB family protein NA NA NA NA NA NA NA LFTS_02485 920.341427902921 0.15451080178772 0.175259647882079 0.881610819460734 0.377987302207127 0.569720972220823 543 hypothetical protein NA K14166 NA Overview 01200 Carbon metabolism COG1276;COG2372 P LFTS_01202 32.4790239659968 -0.339013788743929 0.384890145576575 -0.880806621422009 0.378422495286183 0.569720972220823 1299 MFS transporter%2C NNP family%2C nitrate/nitrite transporter Nitrite uptake & assimilation to ammonia K02575 Energy metabolism Energy metabolism 00910 Nitrogen metabolism COG2223 P LFTS_02094 35316.7641983515 0.151255835776923 0.171804631734882 0.880394400602261 0.378645688804838 0.569720972220823 558 Cytochrome C oxidase%2C cbb3-type%2C subunit III Cytochrome cbb3 oxidase K00406 Energy metabolism; Signal transduction Energy metabolism 00190 Oxidative phosphorylation COG2010 C LFTS_01955 596.717762686146 -0.137809049886313 0.156549498309415 -0.88029058779823 0.378701910151 0.569720972220823 597 anthranilate synthase%2C component II NA K01664 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG0512 EH LFTS_00525 78.5057314270651 -0.235810963762564 0.267965023455573 -0.880006505034267 0.378855785604674 0.569720972220823 900 hypothetical protein NA K13018 Carbohydrate metabolism Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG0110 R LFTS_01767 44.0641859722205 -0.275672217003652 0.31335331155794 -0.879748854840742 0.378995376938082 0.569720972220823 1221 hypothetical protein NA NA NA NA NA NA NA LFTS_00608 854.00157678706 -0.128677398721753 0.146304296663694 -0.87951893181606 0.379119972792082 0.569720972220823 651 hypothetical protein NA K05810 NA Cell growth and death 04112 Cell cycle - Caulobacter COG1496 P LFTS_00416 660.289460186534 -0.134424296977421 0.152889515693326 -0.879225082032806 0.3792792473956 0.569720972220823 312 ferredoxin%2C 2Fe-2S NA K04755 NA Amino acid metabolism 00310 Lysine degradation COG0633 C LFTS_02244 431.18890717747 0.140523796381342 0.160761209880019 0.874115070956601 0.382055590844545 0.573544806062523 1029 beta-N-acetylhexosaminidase NA K01207 Glycan biosynthesis and metabolism; Carbohydrate metabolism; Drug resistance Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG1472 G LFTS_02119 1259.2592556437 -0.129108760472479 0.14843723563514 -0.86978688278613 0.384416881187916 0.576715069910763 1170 2%2C3-diketo-5-methylthiopentyl-1-phosphate enolase NA K08965 Amino acid metabolism Amino acid metabolism 00270 Cysteine and methionine metabolism COG1850 G LFTS_01633 2432.35953005333 0.131580858223196 0.151347693822004 0.869394537177056 0.384631370037025 0.576715069910763 1503 trehalose 6-phosphate synthase Lipopolysaccharide synthesis K00697 Carbohydrate metabolism Carbohydrate metabolism 00500 Starch and sucrose metabolism COG0380 G LFTS_00967 6.93299770976388 -0.3768640405675 0.434088390253455 -0.868173508043966 0.385299354642117 0.577368412079748 195 hypothetical protein NA NA NA NA NA NA NA LFTS_01301 382.344416997932 -0.143761589930138 0.165895619387215 -0.866578577910404 0.386172955189864 0.578328895543375 1074 lipid-A-disaccharide kinase Lipopolysaccharide synthesis K00912 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG1663 M LFTS_01411 238.403466012679 0.18749187703625 0.216554271246774 0.865796254937836 0.386601903312123 0.578609307322446 1716 Sel1 repeat-containing protein NA K13582 Cell growth and death Cell growth and death 04112 Cell cycle - Caulobacter COG0790;COG3409 TM LFTS_01874 138.128736605864 -0.230599821397852 0.266675180061355 -0.864721723801954 0.387191543068893 0.578609307322446 549 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) NA K03270 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG1778 MR LFTS_00987 303.896609932429 -0.180970804189879 0.209399198888457 -0.86423828338655 0.387457005645914 0.578609307322446 1086 hypothetical protein NA K14440 NA Replication and repair 03430 Mismatch repair NA LFTS_01795 455.403464580266 0.144205510887718 0.166897760140305 0.864035028190247 0.387568648489698 0.578609307322446 753 Transposase (or an inactivated derivative) NA K07493 NA Signal transduction 02020 Two-component system COG3328 X LFTS_01806 802.290121117445 0.123288363185012 0.142824355235664 0.863216662043267 0.388018354333682 0.578609307322446 675 Transposase (or an inactivated derivative) NA K07493 NA Overview 01200 Carbon metabolism COG3328 X LFTS_01248 89.2208404538926 -0.213063886376978 0.246836679666961 -0.863177574193793 0.388039841711371 0.578609307322446 1425 Tetratricopeptide repeat protein putative pel operon K12284 NA Translation 00970 Aminoacyl-tRNA biosynthesis NA LFTS_00320 421.173162467065 0.144220999336891 0.167096975612547 0.863097604299559 0.38808380503094 0.578609307322446 720 hypothetical protein NA K06966 NA Signal transduction 02020 Two-component system COG1611 R LFTS_02041 3515.17252146764 0.139160353600414 0.161280648505979 0.862845945186383 0.388222174020048 0.578609307322446 384 hypothetical protein NA NA NA NA NA NA NA LFTS_00817 828.964078464952 -0.127427453628486 0.148103017022652 -0.860397419243636 0.389570007951758 0.579765005791468 2532 DNA mismatch repair protein MutS NA K03555 Replication and repair Replication and repair 03430 Mismatch repair COG0249 L LFTS_00054 1644.62025143642 -0.137566574755399 0.160033642051019 -0.859610348126318 0.390003868823235 0.579765005791468 759 triosephosphate isomerase NA K01803 Carbohydrate metabolism; Overview; Energy metabolism Overview 01200 Carbon metabolism COG0149 G LFTS_01245 205.954935322898 0.17296914302473 0.201341693452821 0.859082587706858 0.390294953118032 0.579765005791468 1317 hypothetical protein putative pel operon K02488 Cell growth and death; Signal transduction Signal transduction 02020 Two-component system COG3706 TK LFTS_01470 21.9473706417213 0.335153634697282 0.390378512273725 0.858535047805807 0.390597086230195 0.579765005791468 951 conjugation TrbI-like protein NA NA NA NA NA NA NA LFTS_01128 36.0225600878187 -0.283530607917543 0.330579850948495 -0.857676616115716 0.391071055713353 0.579765005791468 477 hypothetical protein NA NA NA NA NA NA NA LFTS_01285 100.038823088847 -0.201625433629571 0.235181409934609 -0.857318755277604 0.391268746019519 0.579765005791468 546 RNA polymerase%2C sigma subunit%2C SigZ NA K03088 NA Amino acid metabolism 00270 Cysteine and methionine metabolism COG1595 K LFTS_02506 463.593597692223 -0.148168138191718 0.172851203770029 -0.857200499389347 0.391334086544059 0.579765005791468 450 Transposase DDE domain group 1 NA NA NA NA NA NA NA LFTS_02125 466.826070266735 -0.160263317932348 0.186984609425987 -0.857093631525779 0.39139314048342 0.579765005791468 663 thymidylate kinase NA K00943 Nucleotide metabolism Nucleotide metabolism 00240 Pyrimidine metabolism COG0125 F LFTS_01993 2017.14952229153 -0.120287043461062 0.140502639765193 -0.856119455563862 0.391931708177872 0.579765005791468 1542 uroporphyrinogen III methyltransferase / synthase NA K13542 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0007;COG1587 H LFTS_02161 634.993061368341 -0.134382367574592 0.157006851756287 -0.85590129393325 0.392052379195341 0.579765005791468 945 [acyl-carrier-protein] S-malonyltransferase NA K00645 Overview; Lipid metabolism Overview 01212 Fatty acid metabolism COG0331 I LFTS_01914 1475.15490002766 -0.103563159940141 0.121022496687219 -0.855734782994922 0.392144496000449 0.579765005791468 177 hypothetical protein NA K02571 NA Nucleotide metabolism 00240 Pyrimidine metabolism NA LFTS_00425 1772.5435593451 -0.114538537414201 0.133881169396227 -0.855523879353179 0.392261190479076 0.579765005791468 1443 putative hemolysin NA K03699 NA Energy metabolism 00920 Sulfur metabolism COG1253 R LFTS_02304 801.857393018898 0.163488618356537 0.191112978193496 0.855455343231634 0.392299116533886 0.579765005791468 2271 penicillin-binding protein 1B NA K05365 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00550 Peptidoglycan biosynthesis COG0744 M LFTS_00605 240.070407138851 -0.172098984511486 0.201306133631116 -0.854911777436697 0.392599990042779 0.579765005791468 861 hypothetical protein NA K03589 Cell growth and death Cell growth and death 04112 Cell cycle - Caulobacter COG1589 D LFTS_00342 111.411818887836 -0.206531143625703 0.241632473802131 -0.854732562953553 0.392699219160245 0.579765005791468 1221 putative permease NA K08184 NA Amino acid metabolism 00260 Glycine, serine and threonine metabolism NA LFTS_01315 361.628766395484 0.15569992028205 0.1821736075983 0.854678799716007 0.392728990246514 0.579765005791468 1083 heptosyltransferase-3 Lipopolysaccharide synthesis K02849 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG0859 M LFTS_01330 389.298120226281 0.136412085880642 0.159978215068596 0.852691635683962 0.393830330543662 0.581045817051361 813 dolichol-phosphate mannosyltransferase Lipopolysaccharide synthesis K00721 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00510 N-Glycan biosynthesis COG0463 M LFTS_00915 296.452132341632 -0.145270317401738 0.17099539991891 -0.849556873872795 0.395571497372697 0.583268530527002 2931 Ti-type conjugative transfer relaxase TraA NA K03581 Replication and repair Replication and repair 03440 Homologous recombination COG0507 L LFTS_01461 430.082669291966 -0.150570304559764 0.17815830284198 -0.845148961108563 0.398027674718788 0.586542263989867 726 putative ABC transport system ATP-binding protein NA K02003 NA Carbohydrate metabolism 00052 Galactose metabolism COG1136;COG4181 MQ LFTS_00388 31.7282890584048 -0.311075813795678 0.368330934504403 -0.844555221011336 0.398359219468505 0.586683068482645 108 hypothetical protein NA NA NA NA NA NA NA LFTS_01474 265.430016802986 -0.167204881139555 0.198171882349318 -0.843736655055951 0.398816579744929 0.587008891205384 945 integrase/recombinase XerD NA K04763 NA Folding, sorting and degradation 03018 RNA degradation COG0582 LX LFTS_01185 19.7602895726742 -0.34420072981048 0.408395116345614 -0.842813040690702 0.399333013505418 0.587421225783709 423 nitrogen regulatory protein P-II family protein Nitrate/nitrite regulation K02590 NA Signal transduction 02020 Two-component system COG0347 TE LFTS_00032 401.609742161605 0.170734887630409 0.202875350070927 0.841575319873597 0.400025708671572 0.588065540865848 1191 hypothetical protein NA K02016 Membrane transport Membrane transport 02010 ABC transporters COG0614 P LFTS_00766 1004.74981014517 -0.120966789981854 0.143805161140664 -0.841185316454179 0.400244125158896 0.588065540865848 363 Cytochrome c%2C mono- and diheme variants Cytochrome c K00406 Energy metabolism; Signal transduction Energy metabolism 00190 Oxidative phosphorylation COG2010 C LFTS_01888 302.137384478548 0.15362183727813 0.183477260191337 0.837279982914113 0.402435208137848 0.59093557438316 726 DNA-(apurinic or apyrimidinic site) lyase /endonuclease III NA K10773 Replication and repair Replication and repair 03410 Base excision repair COG0177 L LFTS_01785 317.953115848346 -0.183583779616185 0.219579431129814 -0.836070021092514 0.403115512429134 0.591585102655743 285 Transposase NA K07483 NA Carbohydrate metabolism 00500 Starch and sucrose metabolism COG2963 X LFTS_02127 1675.89951392155 -0.110689515590082 0.132588978488341 -0.834831950981621 0.403812333411156 0.592258089003029 813 hypothetical protein NA NA NA NA NA NA NA LFTS_01302 308.278317531011 -0.148431932272224 0.178086782530972 -0.833480902752623 0.404573563899821 0.592908730059396 969 KDO2-lipid IV(A) lauroyltransferase Lipopolysaccharide synthesis K02517 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG1560 I LFTS_00140 215.7684780601 0.170251146124295 0.204334507139794 0.833198212614275 0.404732950487046 0.592908730059396 219 hypothetical protein NA K09937 NA Overview 01230 Biosynthesis of amino acids COG3242 S LFTS_00154 263.781575927596 0.158745918804608 0.191071083574301 0.830821262092631 0.4060746094041 0.594523839210008 645 DNA replication and repair protein RecR NA K06187 Replication and repair Replication and repair 03440 Homologous recombination COG0353 L LFTS_01509 511.750952363984 0.140552704345257 0.169449829271821 0.829465010081487 0.406841328203759 0.595295786883193 1392 replicative DNA helicase NA K02314 Replication and repair; Cell growth and death Replication and repair 03030 DNA replication COG0305 L LFTS_01954 730.159249623266 -0.123631248137544 0.14920519392147 -0.828598823460623 0.407331453988124 0.595335580002848 1026 anthranilate phosphoribosyltransferase NA K00766 Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG0547 E LFTS_01403 1333.96217050538 -0.135699610005743 0.163821446960822 -0.828338490003665 0.407478830677944 0.595335580002848 798 Outer membrane protein OmpA NA K03286 NA Transport and catabolism 04144 Endocytosis COG2885 M LFTS_01165 12.4111969298174 -0.349086967647823 0.421626995865431 -0.827952126099724 0.407697612721963 0.595335580002848 1401 nitrogenase molybdenum-cofactor synthesis protein NifE Nitrogenase genes K02587 NA Energy metabolism 00910 Nitrogen metabolism COG2710 P LFTS_00670 857.196273804873 -0.122107162451924 0.14752146675511 -0.827724704328125 0.407826425078379 0.595335580002848 771 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase NA K02528 NA Energy metabolism 00190 Oxidative phosphorylation COG0030 J LFTS_02350 778.617311318381 -0.124099053981933 0.150063525908317 -0.826976796865036 0.408250213051015 0.595368193878829 804 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1%2C7-dioic acid hydratase (catechol pathway) NA K16164 Amino acid metabolism Amino acid metabolism 00350 Tyrosine metabolism COG0179 Q LFTS_02418 1390.88546417566 0.125306780360896 0.151549002652886 0.826840019844297 0.408327743589462 0.595368193878829 1473 Outer membrane protein TolC NA K12340 Drug resistance; Signal transduction; Membrane transport; Infectious diseases; Environmental adaptation Membrane transport 03070 Bacterial secretion system COG1538 M LFTS_01732 310.145948249531 -0.179001566399103 0.216600778785182 -0.826412385971298 0.40857019967365 0.595372518399 162 hypothetical protein NA NA NA NA NA NA NA LFTS_01172 5.57837437755716 -0.353425564319182 0.428025203776454 -0.825712040321266 0.408967460576081 0.595557752287965 507 Tetratricopeptide repeat-containing protein NA NA NA NA NA NA NA LFTS_01349 869.95462001984 -0.111928008929817 0.135692915962748 -0.824862581334347 0.409449612242861 0.595557752287965 576 Methyltransferase domain-containing protein NA K03183 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00130 Ubiquinone and other terpenoid-quinone biosynthesis COG2226 H LFTS_01191 100.489376365214 -0.226203893736165 0.274349968582611 -0.824508546163916 0.409650661867403 0.595557752287965 696 molybdate transport system permease protein NA K02018 Membrane transport Membrane transport 02010 ABC transporters COG0555 P LFTS_00134 59.9036396627093 -0.245783772708211 0.29817788454464 -0.824285721536853 0.409777229696882 0.595557752287965 642 hypothetical protein NA K07286 NA Signal transduction 02020 Two-component system COG3056 S LFTS_02440 4111.03604921218 -0.104549742734367 0.126868718894254 -0.824078178179675 0.409895138441154 0.595557752287965 2601 ATP-dependent Clp protease ATP-binding subunit ClpB NA K03695 Aging Aging 04213 Longevity regulating pathway - multiple species COG0542 O LFTS_00631 221.571736707468 0.146632545202042 0.178028869965523 0.82364475621532 0.410141437517073 0.595567531347806 264 hypothetical protein NA NA NA NA NA NA NA LFTS_01748 131.701955628112 0.200203756926549 0.244673076465046 0.818250049490633 0.413214421802921 0.599679540339791 882 hypothetical protein NA NA NA NA NA NA NA LFTS_01441 1026.78563789684 0.140191517827586 0.171468185614607 0.817594921909776 0.413588528125406 0.599781812714931 891 acetyl-CoA carboxylase carboxyl transferase subunit alpha NA K01962 Carbohydrate metabolism; Overview; Energy metabolism; Lipid metabolism Overview 01200 Carbon metabolism COG0825 I LFTS_01127 160.81637251906 0.166806718557307 0.204170176657301 0.81699845338965 0.413929311895361 0.599781812714931 2568 hypothetical protein NA NA NA NA NA NA NA LFTS_00847 267.350682911517 0.151832354304362 0.185873263794899 0.81685956981904 0.414008684882872 0.599781812714931 906 Cell division protein FtsX NA K09811 Membrane transport Membrane transport 02010 ABC transporters COG2177 D LFTS_01243 21.4294474451622 -0.30450999144367 0.373556664999888 -0.815164123610967 0.414978370754259 0.600836476234763 1509 Glycosyltransferase involved in cell wall bisynthesis putative pel operon K08256 NA Glycan biosynthesis and metabolism 00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis COG0438 M LFTS_00606 1457.53428666505 -0.113963662266245 0.139923166496669 -0.814473150655567 0.415373947422405 0.601059157911583 1278 cell division protein FtsA NA K03590 Cell growth and death Cell growth and death 04112 Cell cycle - Caulobacter COG0849 D LFTS_01845 1412.04516877999 -0.203330868166452 0.250705578567991 -0.811034478482132 0.417345870995415 0.603561277076557 1281 diguanylate cyclase (GGDEF) domain-containing protein Putative diguanylate cyclases (GGDEF domain-containing proteins) K13069 NA Nucleotide metabolism 00230 Purine metabolism COG2199 T LFTS_01253 849.030614580466 -0.144167157293436 0.177952718668009 -0.810143044582512 0.417857967378363 0.603950527268959 1686 dihydroxy-acid dehydratase NA K01687 Metabolism of cofactors and vitamins; Amino acid metabolism; Overview Overview 01210 2-Oxocarboxylic acid metabolism COG0129 EG LFTS_01286 176.254947584799 -0.169092926354665 0.209092534077321 -0.808699015011868 0.418688294888248 0.604799012836829 1056 Methyltransferase domain-containing protein NA K07755 NA Amino acid metabolism 00270 Cysteine and methionine metabolism NA LFTS_01070 5.76746350939683 0.348871047598483 0.432300446158001 0.807010611945968 0.419660369279782 0.60577094333005 339 hypothetical protein NA NA NA NA NA NA NA LFTS_02142 215.847556225835 0.145086648184513 0.179855586032281 0.80668413689677 0.419848485662782 0.60577094333005 1410 GTP-binding protein NA K03977 NA Signal transduction 02020 Two-component system COG1160 R LFTS_00791 1042.45121850116 0.109956574144215 0.136554076073306 0.805223668938212 0.4206906203414 0.606290818106201 1584 phosphodiesterase NA K07037 NA Cell growth and death 04112 Cell cycle - Caulobacter COG1480 R LFTS_00269 1680.42320378565 0.106537597991023 0.132309773543946 0.80521336510063 0.420696565258727 0.606290818106201 492 LTXXQ motif family protein NA K06006 NA Metabolism of other amino acids 00410 beta-Alanine metabolism COG3678 O LFTS_00602 1396.10189854318 -0.11541198803156 0.143500038896164 -0.804264506959968 0.421244231230762 0.60672836549228 1395 UDP-N-acetylmuramate--L-alanine ligase NA K01924 Metabolism of other amino acids; Glycan biosynthesis and metabolism Metabolism of other amino acids 00471 D-Glutamine and D-glutamate metabolism COG0773 M LFTS_00114 134.784921480315 0.181580460329052 0.22630651221826 0.802365157543183 0.422341761723614 0.60795693088877 576 hypothetical protein NA NA NA NA NA NA NA LFTS_01003 2468.46108252149 0.152619417435572 0.190315390275238 0.801928930786156 0.422594069807872 0.607968088855538 828 hypothetical protein NA NA NA NA NA NA NA LFTS_00409 526.474209482275 -0.116995544490046 0.146218179820417 -0.800143625325786 0.423627587860271 0.609102477397706 1062 glycerol-3-phosphate dehydrogenase (NAD(P)+) NA K00057 Lipid metabolism Lipid metabolism 00564 Glycerophospholipid metabolism COG0240 C LFTS_01169 19.1356014235555 -0.318288670900204 0.398437386536328 -0.798842381903795 0.424381812048178 0.609774122477886 1572 nitrogen fixation protein NifB Nitrogenase genes K02585 NA Cell motility 02030 Bacterial chemotaxis COG0535 R LFTS_01303 504.111114536024 -0.162481788386898 0.203485914378249 -0.798491575612797 0.424585279971529 0.609774122477886 1710 Glycosyltransferase family 9 (heptosyltransferase) Lipopolysaccharide synthesis K02843 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG0859 M LFTS_00461 1094.54860071467 -0.12329213502456 0.154531834213737 -0.797842953536886 0.424961631408412 0.609836199835398 930 hypothetical protein NA NA NA NA NA NA NA LFTS_02153 538.777415462841 0.116837342759179 0.146598992822438 0.796985985440526 0.42545917063899 0.609836199835398 624 phosphoribosylglycinamide formyltransferase-1 NA K11175 Metabolism of cofactors and vitamins; Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0299 F LFTS_01969 1944.02678796672 -0.140980847512369 0.176931738812524 -0.796809257957676 0.425561817507687 0.609836199835398 432 Cytochrome c NA K02305 Energy metabolism Energy metabolism 00910 Nitrogen metabolism NA LFTS_01171 11.4113121674024 0.337204331910576 0.423451875892515 0.796322678226058 0.425844507467691 0.609836199835398 393 Iron-sulfur cluster assembly accessory protein NA K13628 NA Metabolism of terpenoids and polyketides 00523 Polyketide sugar unit biosynthesis COG0316 O LFTS_01967 984.058830473495 -0.12229549305183 0.153578796027443 -0.796304543434346 0.425855045420053 0.609836199835398 468 hypothetical protein NA K07778 Signal transduction Signal transduction 02020 Two-component system COG4585 T LFTS_01146 174.858926849176 -0.169876306986173 0.213619750465481 -0.79522753217345 0.426481159110704 0.61038120987289 474 hypothetical protein NA NA NA NA NA NA NA LFTS_01126 23.8061959596548 0.295581956935983 0.372716439957491 0.793047811278984 0.427749967383377 0.611844890054704 390 hypothetical protein NA K02472 Carbohydrate metabolism; Cellular community - prokaryotes Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG0677 M LFTS_00003 2253.50819217027 -0.114733254561014 0.144817261512765 -0.792262285327782 0.428207757638037 0.612147490217458 2457 DNA gyrase subunit B NA K02470 NA Signal transduction 02020 Two-component system COG0187 L LFTS_00410 312.452773097973 0.131129292781623 0.165692858257334 0.791399787297826 0.428710734065722 0.612514301659417 312 hypothetical protein NA K00471 Amino acid metabolism Amino acid metabolism 00310 Lysine degradation NA LFTS_02114 754.822743678456 -0.163412797846922 0.206680057601251 -0.790655855932631 0.429144842742873 0.61278235442779 231 Iron-binding zinc finger CDGSH type NA NA NA NA NA NA NA LFTS_00841 2700.43280001546 0.130373698254228 0.1654293386485 0.788092966576161 0.430642328950271 0.614567640511122 1335 signal recognition particle subunit FFH/SRP54 (srp54) NA K03106 Cellular community - prokaryotes; Folding, sorting and degradation; Membrane transport Folding, sorting and degradation 03060 Protein export COG0541 U LFTS_02417 1409.50470383335 0.111160548638017 0.141152517074237 0.787520838750285 0.430977034511106 0.614692431322208 933 thioredoxin reductase (NADPH) Oxidative stress response K00384 Nucleotide metabolism; Metabolism of other amino acids Nucleotide metabolism 00240 Pyrimidine metabolism COG0492 O LFTS_02459 1622.32473388312 -0.113155963614287 0.144122020803314 -0.785140001393078 0.432371488661985 0.616327706888587 588 DnaJ domain-containing protein NA K05801 NA Overview 01200 Carbon metabolism COG1076 O LFTS_01423 85.3990136696057 0.212975284268084 0.271609621440936 0.784122753598393 0.432968085427461 0.61657664917394 951 Transposase NA K07485 NA Metabolism of other amino acids 00471 D-Glutamine and D-glutamate metabolism COG3464 X LFTS_01051 37.4082385559037 -0.289103309776653 0.368755871021744 -0.78399649333205 0.433042167923451 0.61657664917394 414 single-strand DNA-binding protein NA K03111 Replication and repair Replication and repair 03030 DNA replication COG0629 L LFTS_00907 1653.3077256371 -0.106770410403463 0.136277595678167 -0.783477356436577 0.43334684561702 0.616657274301038 1008 PEGA domain-containing protein NA K07286 NA Carbohydrate metabolism 00030 Pentose phosphate pathway COG3056 S LFTS_01724 142.361620377733 0.169467979916186 0.216727550420932 0.781940180595602 0.434249729760485 0.617441082232479 747 Site-specific recombinase XerD NA K14059 NA Folding, sorting and degradation 04141 Protein processing in endoplasmic reticulum COG0582 LX LFTS_01274 45.6701590422492 0.249365190324487 0.319006119000172 0.781694066264456 0.434394389712231 0.617441082232479 159 hypothetical protein NA NA NA NA NA NA NA LFTS_01779 1305.8591804377 -0.12758912210011 0.163595505793731 -0.77990603397737 0.435446186544521 0.617993776226542 1029 pyruvate dehydrogenase E1 component alpha subunit NA K00161 Carbohydrate metabolism; Overview; Signal transduction; Cancers; Endocrine system Overview 01200 Carbon metabolism COG1071 C LFTS_02028 62.3978918152506 -0.255984441336186 0.328355943553765 -0.779594358992533 0.435629677318995 0.617993776226542 777 hypothetical protein NA NA NA NA NA NA NA LFTS_02378 1288.86136421583 0.140727210558093 0.180517419444611 0.779576901725395 0.435639956162834 0.617993776226542 750 cytochrome c-type biogenesis protein Cytochrome c K06196 NA Overview 01200 Carbon metabolism COG0785 CO LFTS_01818 1.36934754977874 -0.253605808456366 0.325409675630012 -0.779343170928677 0.43577759039627 0.617993776226542 207 putative transcriptional regulator (AbrB) NA NA NA NA NA NA NA LFTS_00020 187.950078856765 0.166857962958915 0.214412197485506 0.778211150838068 0.436444544143936 0.618586737024985 489 transcriptional regulator%2C AsnC family NA K03719 NA Cell growth and death 04112 Cell cycle - Caulobacter COG1522 K LFTS_01801 568.911256897513 0.134296105662919 0.172996528711727 0.77629364394186 0.437575625121525 0.619709394159233 1320 Transposase NA K07497 NA Overview 01200 Carbon metabolism COG2801 X LFTS_01819 6.99638155838566 0.336905927124523 0.434144055729942 0.776023356021934 0.43773519555254 0.619709394159233 318 PIN domain-containing protein NA K07062 NA Membrane transport 02010 ABC transporters COG1487 R LFTS_01848 159.456975289332 -0.190201414360186 0.245403861986657 -0.775054690746995 0.438307343359681 0.619935659861595 387 homoserine dehydrogenase NA K00010 Biosynthesis of other secondary metabolites; Carbohydrate metabolism Carbohydrate metabolism 00562 Inositol phosphate metabolism COG0673 R LFTS_00666 951.435503279736 -0.130325416419236 0.168181695669372 -0.774908445895575 0.438393761076703 0.619935659861595 2808 Excinuclease ABC subunit A NA K03701 Replication and repair Replication and repair 03420 Nucleotide excision repair COG0178 L LFTS_01266 326.404002723763 0.132557803164898 0.171649802191259 0.772257243950661 0.439962083334013 0.621565528075728 1227 HTH-type transcriptional regulator / antitoxin HigA NA NA NA NA NA NA NA LFTS_00195 568.084014688065 -0.116139120004909 0.150416891881343 -0.772114877207577 0.440046391558037 0.621565528075728 1029 epoxyqueuosine reductase NA K14120 NA Signal transduction 02020 Two-component system COG1145 C LFTS_02117 281.326375245609 0.137542589852678 0.178817436645102 0.769178847617964 0.441787145635376 0.623669985263796 606 methylthioribulose-1-phosphate dehydratase NA K08964 Amino acid metabolism Amino acid metabolism 00270 Cysteine and methionine metabolism COG0235 G LFTS_01922 4207.25604693081 -0.0985605839257816 0.128450167956845 -0.767305994951245 0.442899604921053 0.624885594684301 696 hypothetical protein NA NA NA NA NA NA NA LFTS_01711 210.839973313634 0.330139252071038 0.431465239992717 0.76515839856905 0.444177228704308 0.625864915695915 459 hypothetical protein NA K13990 Metabolism of cofactors and vitamins; Amino acid metabolism Amino acid metabolism 00340 Histidine metabolism NA LFTS_00231 285.174109860569 -0.148784198014753 0.194502693659211 -0.764946722411146 0.444303270490213 0.625864915695915 291 hypothetical protein NA NA NA NA NA NA NA LFTS_00095 786.929860051862 -0.112466637914854 0.147040208315735 -0.764869957701345 0.444348984796175 0.625864915695915 1560 phenylalanyl-tRNA synthetase%2C alpha subunit NA K01889 Translation Translation 00970 Aminoacyl-tRNA biosynthesis COG0016 J LFTS_02377 653.880083892677 0.135318251316928 0.177303022797396 0.763203295589362 0.445342163673072 0.626558866578781 1251 geranylgeranyl reductase family protein NA K10960 Metabolism of terpenoids and polyketides; Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0644 C LFTS_01069 6.05147675125339 -0.331016167734033 0.433795381160142 -0.763069829947852 0.445421751728017 0.626558866578781 789 hypothetical protein NA NA NA NA NA NA NA LFTS_00368 294.674341818279 -0.135920865905349 0.178233655982656 -0.762599325901589 0.445702386731711 0.626558866578781 975 PD-(D/E)XK nuclease superfamily protein NA K07465 NA Overview 01230 Biosynthesis of amino acids COG2887 L LFTS_01480 424.001042310928 0.132560560378843 0.173883614862197 0.762352223260927 0.445849812943629 0.626558866578781 1482 starch synthase NA K00703 Carbohydrate metabolism; Cellular community - prokaryotes Carbohydrate metabolism 00500 Starch and sucrose metabolism COG0297 G LFTS_01074 69.0563763088387 0.20566683641816 0.271061527031381 0.758745952148163 0.448004542602275 0.628892374496313 2010 hypothetical protein NA K14440 NA Energy metabolism 00190 Oxidative phosphorylation NA LFTS_00385 26.1480907318156 -0.276950261649721 0.365019942066596 -0.758726386513954 0.448016249088081 0.628892374496313 378 hypothetical protein NA NA NA NA NA NA NA LFTS_02372 733.853005157978 -0.136777940045002 0.180560349241021 -0.757519248383953 0.448738838505657 0.629551214743264 477 ribose 5-phosphate isomerase B NA K01808 Carbohydrate metabolism; Overview; Energy metabolism Overview 01200 Carbon metabolism COG0698 G LFTS_00430 496.660234269079 -0.113946918979726 0.150724993340403 -0.755992197806129 0.449653873601485 0.63005826962417 366 helix-turn-helix protein NA K15773 NA Overview 01210 2-Oxocarboxylic acid metabolism COG1396 K LFTS_02070 405.774561844846 -0.182242114349225 0.241134933023929 -0.755768200251352 0.449788185721386 0.63005826962417 546 DNA-binding transcriptional regulator%2C MarR family NA K15973 NA Drug resistance 01501 beta-Lactam resistance COG1846 K LFTS_01484 2889.94243040671 -0.102578723951043 0.135749445253026 -0.755647463308928 0.449860590741312 0.63005826962417 1422 membrane-bound lytic murein transglycosylase D NA K08307 NA Energy metabolism 00190 Oxidative phosphorylation COG0741 M LFTS_01826 409.142708381592 -0.167076088374855 0.221315567945361 -0.754922439148534 0.450295521106459 0.630312311638884 1686 dihydroxy-acid dehydratase NA K01687 Metabolism of cofactors and vitamins; Amino acid metabolism; Overview Overview 01210 2-Oxocarboxylic acid metabolism COG0129 EG LFTS_01909 778.561479480241 -0.120490232051839 0.159878647197122 -0.753635548987855 0.451068092231574 0.631038422784296 1386 dihydrolipoamide dehydrogenase Mercury resistance K00520 NA Signal transduction 02020 Two-component system COG1249 C LFTS_00191 265.144911382219 -0.145608254152678 0.194160902193044 -0.74993601960042 0.453293239464728 0.633794709397814 630 lipoate-protein ligase A NA K03800 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00785 Lipoic acid metabolism COG0095 H LFTS_02031 36.9429029548892 0.241023325560049 0.322258651040905 0.747918868218236 0.454509095912901 0.635137499965976 177 hypothetical protein NA NA NA NA NA NA NA LFTS_01134 122.989490448053 -0.186166955798793 0.249323658647189 -0.746687886777055 0.455251983323948 0.635748152089599 2553 CRISPR-associated endonuclease/helicase Cas3 NA K07012 NA Membrane transport 02010 ABC transporters COG1203 V LFTS_01083 32.4719811214813 0.258080193115581 0.345790942232717 0.74634746488499 0.455457545805139 0.635748152089599 330 hypothetical protein NA NA NA NA NA NA NA LFTS_02188 552.357296083914 -0.125073321642402 0.167878601135614 -0.745022419750605 0.456258166583578 0.636508306468448 963 farnesyl-diphosphate farnesyltransferase NA K02291 Metabolism of terpenoids and polyketides Metabolism of terpenoids and polyketides 00906 Carotenoid biosynthesis COG1562 I LFTS_01469 11.397411928806 0.314412442715771 0.422259656253163 0.744595033079047 0.456516571495821 0.636511607817505 1158 Conjugal transfer protein NA K03204 Membrane transport Membrane transport 03070 Bacterial secretion system COG3504 U LFTS_02367 210.672270779358 0.154750588570155 0.208411578842781 0.742523949146287 0.457769947003953 0.637243431771037 879 hypothetical protein NA NA NA NA NA NA NA LFTS_00307 173.686594392428 -0.169505669218863 0.228347043337411 -0.742316023634242 0.457895885647056 0.637243431771037 1206 methionine-gamma-lyase NA K01761 Amino acid metabolism; Metabolism of other amino acids Amino acid metabolism 00270 Cysteine and methionine metabolism COG0626 E LFTS_00510 570.84250764714 -0.116484159038388 0.156955284243988 -0.742148692855173 0.457997250536819 0.637243431771037 894 PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein Putative diguanylate cyclases (GGDEF domain-containing proteins) NA NA NA NA NA NA LFTS_01147 162.974842804953 0.14893908455542 0.200717350984954 0.742033928928167 0.458066778992294 0.637243431771037 420 hypothetical protein NA K07458 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG3727 L LFTS_01744 673.13148608467 -0.116352349608895 0.156925116611743 -0.741451414031882 0.458419780491435 0.637377837976347 756 putative proteasome-type protease NA K07395 NA Folding, sorting and degradation 04122 Sulfur relay system COG3484 O LFTS_00292 287.644772146853 -0.138580057436338 0.187127213197517 -0.740566030286911 0.458956611221418 0.637626071312518 534 Holliday junction endonuclease RuvC NA K01159 Replication and repair Replication and repair 03440 Homologous recombination COG0817 L LFTS_02369 991.458565976438 -0.109942396198992 0.148508386183802 -0.740311029054755 0.459111290285361 0.637626071312518 654 dTMP kinase NA K00943 Nucleotide metabolism Nucleotide metabolism 00240 Pyrimidine metabolism COG0125 F LFTS_01697 1667.61601340447 -0.10448808949524 0.141375832788356 -0.739080275846453 0.459858253108047 0.63830687729012 1248 hypothetical protein NA K15201 NA Overview 01200 Carbon metabolism NA LFTS_01092 4.51978030971257 0.310674590061361 0.421011664290321 0.737923949411354 0.46056066454827 0.63874921259934 516 hypothetical protein NA K03497 NA Amino acid metabolism 00310 Lysine degradation COG1475 D LFTS_02321 801.29865107834 0.142502460507662 0.193193558258851 0.737614969111597 0.460748456418828 0.63874921259934 705 putative ABC transport system ATP-binding protein NA K05685 Membrane transport Membrane transport 02010 ABC transporters COG0577;COG1136 VM LFTS_02233 309.718719327196 0.126745575539163 0.171908020912467 0.737287154295726 0.460947742318269 0.63874921259934 432 hypothetical protein NA K03704 NA Metabolism of cofactors and vitamins 00770 Pantothenate and CoA biosynthesis COG1278 K LFTS_01347 1119.36878384101 -0.130660296078561 0.177549418239763 -0.735909457625579 0.461785801217164 0.639554040014412 1407 tRNA-2-methylthio-N6-dimethylallyladenosine synthase NA K06168 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0621 J LFTS_01175 12.8067150807675 -0.302878407669529 0.412736058272233 -0.733830741460819 0.463051902100983 0.640299520751309 1161 dTDP-4-amino-4%2C6-dideoxygalactose transaminase NA K13010 Carbohydrate metabolism Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG0399 M LFTS_02468 494.939114723458 -0.108227151541469 0.147524296054967 -0.733622558694628 0.463178808224155 0.640299520751309 639 GTP-binding protein NA K03978 NA Nucleotide metabolism 00230 Purine metabolism COG0218 D LFTS_00443 521.944191222611 -0.157463496509596 0.214661330732048 -0.733543838438933 0.463226800351966 0.640299520751309 1101 DNA repair photolyase NA K03716 NA Folding, sorting and degradation 03050 Proteasome COG1533 L LFTS_00413 2680.12817568562 -0.117575246649582 0.160329584217011 -0.733334694428197 0.463354319320839 0.640299520751309 1077 ATP-binding protein involved in chromosome partitioning NA K03593 NA Replication and repair 03030 DNA replication COG0489 D LFTS_00816 220.183807278778 -0.146616015276175 0.200198362296025 -0.732353719554307 0.463952698815672 0.640463606659906 258 hypothetical protein NA K08992 NA Amino acid metabolism 00270 Cysteine and methionine metabolism COG3771 S LFTS_02236 171.881219119111 0.151877561062988 0.207567514674207 0.731701978035298 0.464350488841798 0.640463606659906 951 lipoic acid synthetase NA K03644 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00785 Lipoic acid metabolism COG0320 H LFTS_01017 140.136219031724 0.156297714803204 0.213692066206673 0.731415618640891 0.464525328122121 0.640463606659906 201 hypothetical protein NA NA NA NA NA NA NA LFTS_00041 962.202476853051 -0.103157391674913 0.141043422747465 -0.731387466820157 0.464542518444467 0.640463606659906 2256 PAS/PAC sensor signal transduction histidine kinase NA K13598 Signal transduction Signal transduction 02020 Two-component system COG5000 T LFTS_01141 4.75683952200472 0.30902963754281 0.422732165967658 0.731029390288822 0.464761201293029 0.640463606659906 615 hypothetical protein NA NA NA NA NA NA NA LFTS_01040 30.6895965512768 0.257817341633167 0.353114193403752 0.730124550214209 0.465314056144132 0.64087021804671 354 hypothetical protein NA NA NA NA NA NA NA LFTS_01428 13.9034409840146 0.304967704469886 0.420520611795572 0.725214640889326 0.468320362283182 0.644653610540416 312 Transposase NA K07487 NA Overview 01230 Biosynthesis of amino acids COG3666 X LFTS_00609 501.975820763348 0.124299101412837 0.17157507909375 0.724458948638564 0.46878402095671 0.644934740508235 693 hypothetical protein NA K06997 NA Cell growth and death 04112 Cell cycle - Caulobacter COG0325 R LFTS_01948 1021.90541229991 0.104480387704114 0.144343874830657 0.723829728325425 0.469170275883189 0.645109129339384 1335 dihydrofolate synthase / folylpolyglutamate synthase NA K11754 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG0285 H LFTS_01685 1217.40134755663 0.0954938951930257 0.132143540905033 0.722652764857069 0.469893242276133 0.645408749342545 948 hypothetical protein NA NA NA NA NA NA NA LFTS_01749 10.1421142245781 -0.307502085049567 0.425778825122662 -0.722210844940397 0.470164856691164 0.645408749342545 351 addiction module antidote protein%2C HigA family NA K07110 NA Folding, sorting and degradation 04122 Sulfur relay system COG3800 R LFTS_01325 850.057147461174 0.101331386775627 0.140385339570655 0.721808894614864 0.470411980146457 0.645408749342545 1281 2-C-methyl-D-erythritol 2%2C4-cyclodiphosphate synthase NA K12506 Metabolism of terpenoids and polyketides Metabolism of terpenoids and polyketides 00900 Terpenoid backbone biosynthesis COG1211;COG0245 I LFTS_01695 1000.21915321657 0.116039283831128 0.160767095463166 0.721785036277612 0.470426650767776 0.645408749342545 1389 putative radical SAM enzyme NA K08669 Cell growth and death; Neurodegenerative diseases Cell growth and death 04210 Apoptosis NA LFTS_00677 1372.10162692272 -0.105287415101312 0.146107800506549 -0.720614606039415 0.471146664809416 0.645811039512216 855 hypothetical protein NA K09769 NA Xenobiotics biodegradation and metabolism 00627 Aminobenzoate degradation COG1692 R LFTS_01100 64.9270524750311 -0.209430299614509 0.290688132168283 -0.720463880146531 0.471239431084135 0.645811039512216 1320 hypothetical protein NA NA NA NA NA NA NA LFTS_00634 179.705570507165 -0.201801961861377 0.280725258861838 -0.718859295667071 0.472227618434678 0.646808737977196 303 hypothetical protein NA NA NA NA NA NA NA LFTS_00309 21.6253322992362 -0.272161765229918 0.380131764367835 -0.715966911322255 0.474011780533201 0.648387509170658 1530 Putative beta-barrel porin-2%2C OmpL-like. bbp2 NA K09993 Cell growth and death Cell growth and death 04110 Cell cycle NA LFTS_02093 783.713492212635 0.103476719214566 0.144562838758089 0.715790587010563 0.47412066555008 0.648387509170658 1392 DNA-binding transcriptional response regulator%2C NtrC family%2C contains REC%2C AAA-type ATPase%2C and a Fis-type DNA-binding domains NA K02481 NA Overview 01210 2-Oxocarboxylic acid metabolism COG2204 T LFTS_01088 21.6357572855848 -0.269257245249903 0.376669146312013 -0.714837538158394 0.474709436770941 0.648387509170658 690 YqaJ-like viral recombinase domain protein NA NA NA NA NA NA NA LFTS_01683 658.252765311776 0.126645133309215 0.177169018579889 0.714826634613363 0.474716175047307 0.648387509170658 225 hypothetical protein NA K02664 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG3167 NW LFTS_01735 94.1201180940553 0.231607206675726 0.324177969494575 0.714444621381349 0.474952288365298 0.648387509170658 339 hypothetical protein NA K02016 Membrane transport Membrane transport 02010 ABC transporters COG0614 P LFTS_00259 416.76788624624 -0.124741791932949 0.174612560418844 -0.714391860664152 0.474984903578987 0.648387509170658 873 N-acetylglutamate kinase NA K00930 Overview; Amino acid metabolism Overview 01210 2-Oxocarboxylic acid metabolism COG0548 E LFTS_01603 952.233009902245 0.171956092502919 0.241017904699424 0.713457752100898 0.475562547127964 0.648387509170658 333 hypothetical protein NA NA NA NA NA NA NA LFTS_02407 1532.13888173138 -0.118607863997865 0.166274146165872 -0.713327157185 0.475643336428457 0.648387509170658 450 RDD family protein NA NA NA NA NA NA NA LFTS_01427 49.5486809962785 0.210048911087094 0.294519874378583 0.713190957079835 0.475727601257956 0.648387509170658 363 Transposase DDE domain group 1 NA K01998 Cellular community - prokaryotes; Membrane transport Membrane transport 02010 ABC transporters COG0559 E LFTS_01205 56.6723822914965 -0.20430304573452 0.287364388821581 -0.710954640456052 0.477112344665681 0.649918514432265 1602 hypothetical protein NA NA NA NA NA NA NA LFTS_01090 322.303516127427 0.132770882949421 0.18797371408812 0.706326858483943 0.479984894400828 0.653473410449321 1011 helix-turn-helix protein NA K07729 NA Amino acid metabolism 00310 Lysine degradation COG1476 K LFTS_02363 485.209868072389 -0.125139336822038 0.177317432240578 -0.705736233830934 0.480352183428237 0.653615505201203 864 4-hydroxybenzoate polyprenyltransferase NA K06125 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00130 Ubiquinone and other terpenoid-quinone biosynthesis COG0382 H LFTS_00612 519.994160585487 0.116077582143612 0.165224526845186 0.702544497236634 0.482339661951849 0.655889589306335 528 cell division initiation protein NA K04074 NA Overview 01230 Biosynthesis of amino acids COG3599 D LFTS_00244 312.049163648326 0.128536746726594 0.183117014236072 0.701937759649605 0.482717979427053 0.655889589306335 1068 A/G-specific DNA-adenine glycosylase NA K03575 Replication and repair Replication and repair 03410 Base excision repair COG1194 L LFTS_00923 2175.03528489799 0.134887968940686 0.192207712106378 0.701782293033235 0.482814943053336 0.655889589306335 312 hypothetical protein NA NA NA NA NA NA NA LFTS_02065 152.329194133917 -0.143827440984791 0.205394949684406 -0.700248186266435 0.483772323634761 0.656831237878764 1095 hypothetical protein NA K07404 Carbohydrate metabolism; Overview Overview 01200 Carbon metabolism COG2706 G LFTS_00643 1668.21407861107 0.110126537189895 0.157453486710763 0.699422664371949 0.484287927932945 0.657172373821671 1209 Site-specific recombinase XerD NA K04763 NA Nucleotide metabolism 00230 Purine metabolism COG0582 LX LFTS_00803 5033.19314646628 0.0875636002368649 0.12539090572869 0.698324968050932 0.484973988096138 0.657744317734315 1449 NusA antitermination factor NA K02600 NA Translation 03010 Ribosome COG0195 K LFTS_01071 13.0772680437798 -0.299201499463264 0.429563722475364 -0.696524133227809 0.486100649133113 0.658912875542486 609 hypothetical protein NA NA NA NA NA NA NA LFTS_00704 211.429797087478 0.155883403762116 0.224382214732708 0.694722636318615 0.487229139257752 0.660082637708322 339 nitrogen regulatory protein P-II family protein Nitrate/nitrite regulation K04751 Signal transduction Signal transduction 02020 Two-component system COG0347 TE LFTS_01174 9.99726654478371 -0.29598398721987 0.426537886878853 -0.693921914851931 0.487731179397899 0.660402893237024 1164 cysteine desulfurase Nitrogenase genes K04487 Metabolism of cofactors and vitamins; Folding, sorting and degradation Metabolism of cofactors and vitamins 00730 Thiamine metabolism COG1104 E LFTS_02219 3.18592500041971 -0.279368501402843 0.402946846627025 -0.693313531899733 0.488112812776371 0.660559854415928 93 hypothetical protein NA NA NA NA NA NA NA LFTS_01631 1844.55603776131 0.104291948939549 0.15082291701972 0.691486088456388 0.489260120159427 0.661752262631303 1287 putative arabinose efflux permease%2C MFS family Lipopolysaccharide synthesis K08217 NA Carbohydrate metabolism 00630 Glyoxylate and dicarboxylate metabolism COG0477 GEPR LFTS_02097 1272.04115931162 -0.096452810783743 0.139714030126503 -0.690358804311995 0.489968576413685 0.662350125592398 1284 enolase NA K01689 Overview; Signal transduction; Energy metabolism; Carbohydrate metabolism; Folding, sorting and degradation Overview 01200 Carbon metabolism COG0148 G LFTS_01269 62.269464899683 -0.204940908574982 0.297711753483651 -0.688387025963475 0.491209091771995 0.663218135672265 282 hypothetical protein NA NA NA NA NA NA NA LFTS_01359 1309.65303403927 -0.123874451920524 0.179964051566995 -0.688328868137366 0.491245706507559 0.663218135672265 813 acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase NA K00677 Glycan biosynthesis and metabolism; Drug resistance Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG1043 M LFTS_00418 1598.79715918108 -0.111664658944201 0.16228764163675 -0.688066311260727 0.491411024098275 0.663218135672265 678 Co-chaperone protein HscB NA K04082 NA Replication and repair 03030 DNA replication COG1076 O LFTS_00622 8779.28355596681 -0.093561800966646 0.13691676947235 -0.683348002784571 0.494386968292877 0.666701047604436 1440 hopanoid biosynthesis associated radical SAM protein HpnJ NA K04034 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG1032 R LFTS_00046 242.629460216712 0.13234989724368 0.193789852812567 0.682955765344889 0.494634794510583 0.666701047604436 198 hypothetical protein NA K02710 Energy metabolism Energy metabolism 00195 Photosynthesis NA LFTS_00754 498.851935272728 -0.123600553081805 0.181061203251361 -0.68264515457911 0.494831093898366 0.666701047604436 810 arsenate reductase (thioredoxin) Arsenic resistance K03741 NA Energy metabolism 00190 Oxidative phosphorylation COG0394 T LFTS_02144 110.265631159822 0.152349664124949 0.223296221714324 0.682276049972126 0.495064414271033 0.666701047604436 969 Sigma-54 interaction domain-containing protein NA K02481 NA Signal transduction 02020 Two-component system COG2204 T LFTS_01323 767.657728037465 0.0994805680980604 0.147652207566381 0.673749277018675 0.500470727554619 0.673591543885955 1362 putative inorganic carbon (hco3(-)) transporter Lipopolysaccharide synthesis K02847 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG3307 M LFTS_02355 1611.85251020465 0.0948687489085081 0.140949680033703 0.673068210483511 0.500903896996518 0.673591543885955 1404 argininosuccinate lyase NA K01755 Amino acid metabolism; Overview Overview 01230 Biosynthesis of amino acids COG0165 E LFTS_00583 916.747358586094 -0.11209087241953 0.166639495910681 -0.672654893769064 0.501166870024427 0.673591543885955 603 hypothetical protein NA NA NA NA NA NA NA LFTS_00389 45.0136003609303 -0.226121814965071 0.336240134174726 -0.672500965775749 0.501264825498398 0.673591543885955 786 hypothetical protein NA K06297 NA Folding, sorting and degradation 04141 Protein processing in endoplasmic reticulum NA LFTS_02481 2593.55864824508 0.0902711120712265 0.134332475649086 0.671997680643063 0.50158517286862 0.673657882091512 993 octaprenyl-diphosphate synthase NA K02523 Metabolism of terpenoids and polyketides Metabolism of terpenoids and polyketides 00900 Terpenoid backbone biosynthesis COG0142 H LFTS_00394 1774.35629255278 -0.105004740274127 0.156484460115424 -0.671023437066371 0.502205599130787 0.674126954340787 1446 zinc protease NA K07263 NA Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG0612 R LFTS_00511 442.957379493597 -0.104460992329607 0.156053150903437 -0.669393675967784 0.503244384660162 0.674887930246122 2244 PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein Putative diguanylate cyclases (GGDEF domain-containing proteins) K13069 NA Signal transduction 02020 Two-component system COG2199 T LFTS_01535 767.812166980561 0.095745603086131 0.143057140604448 0.669282237024901 0.503315455622007 0.674887930246122 909 prephenate dehydrogenase NA K04517 Overview; Amino acid metabolism; Biosynthesis of other secondary metabolites Overview 01230 Biosynthesis of amino acids COG0287 E LFTS_02198 524.763277820277 0.103381968804793 0.154994050519721 0.66700604609103 0.504768271464706 0.676163490761476 711 outer membrane lipoprotein NA K07285 NA Carbohydrate metabolism 00630 Glyoxylate and dicarboxylate metabolism COG3065 M LFTS_00514 8980.91264165192 -0.165250679487242 0.247774580670678 -0.666939599049833 0.504810715548391 0.676163490761476 858 DSF synthase Quorum sensing K13816 Cellular community - prokaryotes; Signal transduction Signal transduction 02020 Two-component system COG1024 I LFTS_02270 701.649419085948 0.125630807458757 0.188557689997603 0.666272520947587 0.505236926302258 0.676369950881752 618 ATP phosphoribosyltransferase NA K00765 Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG0040 E LFTS_02375 698.838146599508 0.0945971960494229 0.142084009468194 0.665783548785612 0.505549461635631 0.676424091295037 1986 replication restart DNA helicase PriA NA K04066 Replication and repair Replication and repair 03440 Homologous recombination COG1198 L LFTS_00594 791.424352920831 -0.110642077546737 0.166383757422071 -0.664981241324344 0.506062491300189 0.676746290141082 1737 peptidoglycan synthetase FtsI NA K03587 Drug resistance; Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00550 Peptidoglycan biosynthesis COG0768 DM LFTS_01158 43.8566717049337 0.199869511970684 0.301926530634584 0.661980620088607 0.507983641963717 0.67895017952785 1140 Transposase NA K07485 NA Cellular community - prokaryotes 02026 Biofilm formation - Escherichia coli COG3464 X LFTS_02373 2522.80647895675 -0.0764980137848905 0.116670186106949 -0.655677481432716 0.512031660698427 0.683802308241066 1245 glycine hydroxymethyltransferase NA K00600 Carbohydrate metabolism; Overview; Amino acid metabolism; Metabolism of cofactors and vitamins; Energy metabolism; Drug resistance; Metabolism of other amino acids Overview 01200 Carbon metabolism COG0112 E LFTS_01576 778.749837082251 0.089780940484839 0.137025559524029 0.655213091606424 0.512330566572917 0.683802308241066 903 glycyl-tRNA synthetase alpha chain NA K14164 Translation Translation 00970 Aminoacyl-tRNA biosynthesis NA LFTS_00366 157.66344084337 -0.137125601142527 0.209337858353517 -0.65504444452163 0.512439139281217 0.683802308241066 201 hypothetical protein NA NA NA NA NA NA NA LFTS_01497 362.702613942622 0.114676904779794 0.175410343707505 0.653763639908351 0.513264095277101 0.68451945697949 642 Peptidase_C39 like family protein NA K06992 NA Overview 01200 Carbon metabolism COG3271 R LFTS_02374 1045.45313724118 0.112217169284771 0.171755206128376 0.653355271227682 0.513527267605289 0.68451945697949 468 transcriptional repressor NrdR NA K07738 NA Replication and repair 03440 Homologous recombination COG1327 K LFTS_01761 36.7825209168855 -0.213011180760406 0.327248023021001 -0.650916631348865 0.515100304867834 0.68624831613153 246 prevent-host-death family protein NA K15656 Cellular community - prokaryotes; Metabolism of terpenoids and polyketides Metabolism of terpenoids and polyketides 01054 Nonribosomal peptide structures NA LFTS_00922 1844.54097833689 -0.110365582257309 0.169770586911048 -0.650086591943843 0.515636289577013 0.686594438076301 204 hypothetical protein NA NA NA NA NA NA NA LFTS_01763 24.6656653074528 -0.242960150094482 0.375058265695516 -0.647793082613263 0.517118790045045 0.688199845852239 192 Putative restriction endonuclease NA NA NA NA NA NA NA LFTS_00132 313.573447052735 -0.10507439736617 0.162316247154271 -0.647343683755233 0.517409535179172 0.688218354443779 714 uracil-DNA glycosylase%2C family 4 NA K02334 NA Signal transduction 02020 Two-component system COG1573 L LFTS_02061 19.8705021867143 -0.249912983044855 0.387402723804305 -0.645098673005453 0.518863243753715 0.689146593904476 420 biopolymer transport protein ExbD NA K03559 NA Replication and repair 03440 Homologous recombination COG0848 U LFTS_01042 18.2381279123186 0.247064140350281 0.383277271009061 0.644609422572413 0.519180327131736 0.689146593904476 762 transposase%2C IS605 OrfB family%2C central region NA K07496 NA Folding, sorting and degradation 03018 RNA degradation COG0675 X LFTS_01232 227.483340972276 0.147385103077706 0.228652866519922 0.64458016783649 0.519199290305867 0.689146593904476 684 putative isomerase YddE NA K06998 Cellular community - prokaryotes;NA Biosynthesis of other secondary metabolites 00405 Phenazine biosynthesis COG0384 R LFTS_00906 1443.34105279549 -0.086295375497409 0.133883852494025 -0.644554021189822 0.519216239092149 0.689146593904476 1008 cytoskeleton protein RodZ NA K15539 NA Carbohydrate metabolism 00030 Pentose phosphate pathway COG1426 D LFTS_01698 1112.97695514326 -0.0958279304556059 0.148953751259117 -0.643340161933253 0.520003401597589 0.689823082375457 654 hypothetical protein NA NA NA NA NA NA NA LFTS_01900 153.141677910745 0.13678639866714 0.21283116748321 0.64269909470816 0.520419368561267 0.690006693463098 522 hypothetical protein NA K09705 NA Nucleotide metabolism 00230 Purine metabolism COG3542 R LFTS_01573 241.112072844873 -0.128345597383585 0.200586978670418 -0.6398500951274 0.522270060895038 0.69209134935238 633 riboflavin synthase alpha chain NA K00793 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00740 Riboflavin metabolism COG0307 H LFTS_02242 572.051329783779 0.0914156452935078 0.143685441507741 0.636220652101228 0.524632614223728 0.694851720277137 720 putative glutamine amidotransferase NA K07010 NA Metabolism of other amino acids 00471 D-Glutamine and D-glutamate metabolism COG2071 E LFTS_00595 570.45341377468 0.0950082947020066 0.149595420088044 0.635101627082496 0.525362135942932 0.695319341033948 1545 UDP-N-acetylmuramoylalanyl-D-glutamate--2%2C 6-diaminopimelate ligase NA K01928 Amino acid metabolism; Glycan biosynthesis and metabolism Amino acid metabolism 00300 Lysine biosynthesis COG0769 M LFTS_00051 1349.84824268497 0.0935923681406842 0.147433925235541 0.634808901622614 0.525553056941827 0.695319341033948 2373 penicillin-binding protein 1A NA K05366 Drug resistance; Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00550 Peptidoglycan biosynthesis COG0744 M LFTS_00496 761.896704631291 0.132272869394654 0.208514221312781 0.634358983103788 0.525846571356021 0.695319341033948 1917 maltooligosyl trehalose hydrolase NA K01236 Carbohydrate metabolism Carbohydrate metabolism 00500 Starch and sucrose metabolism COG0296 G LFTS_01842 985.736210329373 0.268977097117084 0.424278332153549 0.633963784461514 0.526104457154005 0.695319341033948 1038 hypothetical protein NA K05802 NA Nucleotide metabolism 00230 Purine metabolism COG3264 M LFTS_01010 496.151148815682 0.125614398502431 0.198370511892281 0.633231206111126 0.52658267005797 0.695581571606862 207 hypothetical protein NA NA NA NA NA NA NA LFTS_00869 663.774749572223 0.0977391006971387 0.155130216491753 0.630045537919651 0.528664790748293 0.697949814848582 768 BirA family transcriptional regulator%2C biotin operon repressor / biotin-[acetyl-CoA-carboxylase] ligase NA K03524 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00780 Biotin metabolism COG1654;COG0340 KH LFTS_00382 2.98723814088881 0.223029849893394 0.354223960571017 0.629629485068897 0.528937027825715 0.697949814848582 177 DNA binding domain-containing protein%2C excisionase family NA K07450 NA Folding, sorting and degradation 03018 RNA degradation COG2452 X LFTS_02291 48.3915530632127 0.204271383854717 0.32467907619104 0.629148592669165 0.529251780416555 0.69799465576422 339 hypothetical protein NA NA NA NA NA NA NA LFTS_02507 172.383871408408 0.124810764162565 0.199263366234103 0.626360813436887 0.531078306362304 0.700032168407575 456 large conductance mechanosensitive channel NA K03282 NA Membrane transport 02010 ABC transporters COG1970 M LFTS_01774 124.13643529999 -0.154126259284666 0.24645826985705 -0.625364526717089 0.531731838473257 0.700522178295981 1104 extracellular solute-binding protein NA K02048 Energy metabolism; Membrane transport Energy metabolism 00920 Sulfur metabolism COG1613 P LFTS_01855 189.804052770593 -0.135739933069115 0.217773224996452 -0.623308641690579 0.533081720066338 0.701666719095209 432 hypothetical protein NA NA NA NA NA NA NA LFTS_01408 75.3319591776733 0.164046136176256 0.263239637434229 0.623181743354452 0.533165097494308 0.701666719095209 588 hypothetical protein NA NA NA NA NA NA NA LFTS_00026 750.416801040892 0.0886591847747968 0.143038723017417 0.619826456112877 0.535372048812673 0.704198366850955 3168 ATP-dependent helicase IRC3 NA K01153 NA Cell growth and death 04112 Cell cycle - Caulobacter COG0610 V LFTS_00053 3272.45701835958 0.0727650048550284 0.117601494396227 0.618742178648394 0.536086218932535 0.704370355826225 1200 phosphoglycerate kinase NA K15330 NA NA NA NA LFTS_01877 958.18112944271 0.10086366944526 0.163087146929094 0.618464859705421 0.536268954797783 0.704370355826225 1638 CTP synthase NA K01937 Nucleotide metabolism Nucleotide metabolism 00240 Pyrimidine metabolism COG0504 F LFTS_00081 60.0329794892182 -0.183665459183807 0.29707336527874 -0.618249498777772 0.536410885822688 0.704370355826225 1131 processive 1%2C2-diacylglycerol beta-glucosyltransferase Lipopolysaccharide synthesis K03715 Lipid metabolism Lipid metabolism 00561 Glycerolipid metabolism NA LFTS_00246 7973.32210009419 0.101476555245292 0.164226057593782 0.617907759171184 0.536636143980237 0.704370355826225 528 hypothetical protein NA NA NA NA NA NA NA LFTS_00596 523.833048056275 -0.10706730766598 0.173827018567786 -0.615941690469871 0.537933004625131 0.705699973349908 1488 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase NA K01929 Amino acid metabolism; Glycan biosynthesis and metabolism; Drug resistance Amino acid metabolism 00300 Lysine biosynthesis COG0770 M LFTS_01964 1324.8191477357 0.0896543731658362 0.145658660186395 0.615510077129009 0.538217916409464 0.705701339764729 567 cytochrome c oxidase cbb3-type subunit 1 Cytochrome cbb3 oxidase K00404 Energy metabolism; Signal transduction Energy metabolism 00190 Oxidative phosphorylation COG3278 C LFTS_02517 698.24209628619 0.0882072263857638 0.143621352932603 0.614165126456903 0.539106215569808 0.706493438010829 876 ribosomal protein L11 methyltransferase NA K02687 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG2264 J LFTS_01013 172.681867003969 0.120350949972857 0.19657953438418 0.612225226546994 0.540388753363231 0.707659150768721 627 hypothetical protein NA NA NA NA NA NA NA LFTS_00672 1323.7851357564 0.0750646451951555 0.122662918394688 0.611958741708907 0.540565055233227 0.707659150768721 2061 soluble lytic murein transglycosylase NA K08309 NA Energy metabolism 00190 Oxidative phosphorylation COG0741 M LFTS_01297 573.745335961894 0.124184349490784 0.203403047789628 0.61053337617253 0.541508541018375 0.708120094895473 1218 lipid-A-disaccharide synthase Lipopolysaccharide synthesis K00748 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG0763 M LFTS_00282 1110.81380022665 0.118412671472791 0.193952517073999 0.610524025463475 0.541514733204379 0.708120094895473 987 Thiamine biosynthesis protein (ThiI) NA K03151 Metabolism of cofactors and vitamins; Folding, sorting and degradation Metabolism of cofactors and vitamins 00730 Thiamine metabolism COG0301 HJ LFTS_01242 16.7689034722346 -0.244059320123988 0.400008033047 -0.610136047181111 0.541771689658564 0.708120094895473 1380 putative membrane protein putative pel operon K05310 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis NA LFTS_00526 118.959812643625 0.149407299750392 0.245450706606564 0.608705926399629 0.542719378106173 0.708986008393035 816 methyltransferase%2C FkbM family NA NA NA NA NA NA NA LFTS_01776 2569.65938173154 0.0891496538913446 0.146785560707524 0.607346209406651 0.543621177968076 0.70979109686378 1488 hypothetical protein NA K04034 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG1032 R LFTS_01023 107.463654790034 0.145675710498217 0.240139161624072 0.606630378456415 0.544096235195444 0.710038446559514 465 hypothetical protein NA NA NA NA NA NA NA LFTS_00107 429.356824757975 -0.0988963513781762 0.164136864966556 -0.602523701170528 0.546825591398282 0.712904223478331 693 nicotinate-nucleotide adenylyltransferase NA K00969 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00760 Nicotinate and nicotinamide metabolism COG1057 H LFTS_00412 1043.12356056227 0.123212074500198 0.20451382837906 0.602463292955569 0.546865790093796 0.712904223478331 258 hypothetical protein NA NA NA NA NA NA NA LFTS_00774 1108.71004257244 0.100573762345993 0.167433940286766 0.600677271129967 0.548054960424867 0.714079995605985 963 GTP-binding protein Era NA K03595 NA Replication and repair 03440 Homologous recombination COG1159 J LFTS_02169 1370.64384452233 0.0744651903110205 0.124059101950739 0.600239636915872 0.54834654115029 0.714085647616355 1182 1-deoxy-D-xylulose 5-phosphate reductoisomerase NA K00099 Metabolism of terpenoids and polyketides Metabolism of terpenoids and polyketides 00900 Terpenoid backbone biosynthesis COG0743 I LFTS_01636 530.802876728943 -0.121422828717695 0.202673657337223 -0.599105134396736 0.549102778024404 0.714696076528098 432 hypothetical protein NA K04925 NA Translation 03010 Ribosome NA LFTS_01814 713.210960824824 -0.135533903910046 0.226969008590489 -0.597147182127337 0.550409119235224 0.716021491584912 1512 undecaprenyl-phosphate galactose phosphotransferase Lipopolysaccharide synthesis K00996 NA Membrane transport 02010 ABC transporters COG2148 M LFTS_02129 579.164210555918 0.102121331100762 0.171283030301213 0.596213944377178 0.551032311304341 0.716089504562204 792 TatD DNase family protein NA K03424 NA Metabolism of other amino acids 00450 Selenocompound metabolism COG0084 N LFTS_01463 3.15407073130293 -0.230666251205058 0.386890072060745 -0.596206178091955 0.551037498884753 0.716089504562204 264 TrbC/VIRB2 family protein NA K03197 Infectious diseases; Membrane transport Membrane transport 03070 Bacterial secretion system COG3838 U LFTS_00308 78.3875658212541 -0.156610814954032 0.263120606907257 -0.595205433716688 0.551706158606902 0.71658386117908 435 hypothetical protein NA NA NA NA NA NA NA LFTS_00633 306.929837718446 0.145193491882725 0.244190319624839 0.59459151413452 0.552116553760974 0.716676173322579 405 hypothetical protein NA NA NA NA NA NA NA LFTS_00472 1462.20019072225 -0.128064917301547 0.215511620880649 -0.594236713446045 0.552353800517321 0.716676173322579 207 putative cobalt transporter subunit (CbtB) NA NA NA NA NA NA NA LFTS_01032 38.3367078917026 0.211741108236407 0.356815501811581 0.593419027932867 0.552900757777153 0.717011624326553 327 hypothetical protein NA K07070 NA Cell motility 02040 Flagellar assembly COG3529 R LFTS_00363 140.042760573953 0.140990671186051 0.237965530217676 0.592483588093963 0.553526807521337 0.717449240614204 1326 anthranilate synthase component 1 NA K01665 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG0147 EH LFTS_01960 656.677815854791 -0.0946024515610709 0.160258027980801 -0.590313338763935 0.554980598347866 0.718958711564771 327 hypothetical protein NA NA NA NA NA NA NA LFTS_00524 175.096689799708 -0.119057215296354 0.202101677845485 -0.589095630306338 0.555797124527845 0.719641485195949 1830 hypothetical protein NA K06147 NA Overview 01200 Carbon metabolism COG1132;COG2274;COG5265 VO LFTS_00378 1938.32843080377 -0.0850843770204381 0.144648052987638 -0.588216538439751 0.55638695787722 0.720030180782285 2487 leucyl-tRNA synthetase NA K01869 Translation Translation 00970 Aminoacyl-tRNA biosynthesis COG0495 J LFTS_01875 312.65317042878 -0.0987452396839494 0.168436764049081 -0.586245171838944 0.557710769953231 0.721367832520152 999 arabinose-5-phosphate isomerase NA K06041 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG0794;COG0517 GMT LFTS_01445 200.712417623566 0.119369378589146 0.204406326277281 0.583980842291638 0.559233201259965 0.722960862367277 2145 Methyl-accepting chemotaxis protein Chemotaxis K03406 Signal transduction; Cell motility Signal transduction 02020 Two-component system COG0840 NT LFTS_01318 205.790360612397 -0.132971220003595 0.228742310869248 -0.581314490958355 0.561028515904441 0.724616048334705 288 hypothetical protein NA K01430 Nucleotide metabolism; Amino acid metabolism; Xenobiotics biodegradation and metabolism Nucleotide metabolism 00230 Purine metabolism COG0831 E LFTS_02509 1440.24051225751 -0.0718244872314312 0.123576747478271 -0.581213607714191 0.561096497604307 0.724616048334705 1128 cobalt-precorrin-5B (C1)-methyltransferase NA K02188 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG1903 H LFTS_02513 550.46870072041 0.111542323731554 0.192135476556847 0.580539969663293 0.56155054094756 0.724825879956197 822 precorrin-3B C17-methyltransferase NA K05934 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG1010 H LFTS_00538 87.6005920932247 0.15495309257654 0.268413750963946 0.577291930909135 0.563742263679719 0.727130482286473 1323 putative PEP-CTERM system histidine kinase Extracellular polysaccharide production and export K00936 NA Metabolism of terpenoids and polyketides 00523 Polyketide sugar unit biosynthesis NA LFTS_01101 43.7252779876185 0.182501918735164 0.316279499304459 0.577027341754713 0.563920985457892 0.727130482286473 1134 Competence protein ComGC NA NA NA NA NA NA NA LFTS_00304 184.27855017617 -0.143686394410938 0.249611190684228 -0.575640835721622 0.564857973311695 0.727961079135756 840 oligopeptide transport system permease protein NA K02034 Cellular community - prokaryotes Cellular community - prokaryotes 02024 Quorum sensing COG1173 EP LFTS_02502 648.548739388602 0.104538974717362 0.182704027787459 0.572176628962843 0.567202319078517 0.730603608927044 1338 tRNA modification GTPase NA K03650 NA Translation 03010 Ribosome COG0486 J LFTS_00824 116.393483122229 -0.126654452879808 0.222379096313699 -0.569542978541216 0.568987712636503 0.732362056573203 189 hypothetical protein NA K06199 NA Replication and repair 03440 Homologous recombination COG0239 DP LFTS_01039 54.4720274226202 0.161371740742787 0.283459435892759 0.569293945832301 0.56915667469808 0.732362056573203 612 hypothetical protein NA NA NA NA NA NA NA LFTS_00022 443.793341853068 -0.103504494658253 0.182084476782644 -0.568442167542965 0.569734764638674 0.732726655401833 1026 NADPH:quinone reductase NA K00344 NA Cell growth and death 04112 Cell cycle - Caulobacter COG0604 CR LFTS_01609 353.880130715903 -0.0903714651124865 0.159669546530515 -0.565990616721737 0.571400159205302 0.734488519019845 483 hypothetical protein NA NA NA NA NA NA NA LFTS_01465 40.4304470867614 -0.181429436799425 0.321263108873739 -0.564737848162732 0.572252086742984 0.735040480509906 2553 Type IV secretory pathway%2C VirB4 component NA K12063 NA Membrane transport 03070 Bacterial secretion system NA LFTS_01095 5.80409864159302 0.242538035796876 0.429658918553538 0.564489704096888 0.572420905175856 0.735040480509906 339 hypothetical protein NA NA NA NA NA NA NA LFTS_00303 197.280214308269 -0.117183064962148 0.207873916558587 -0.56372183149357 0.572943457337768 0.73533166491569 273 hypothetical protein NA NA NA NA NA NA NA LFTS_01617 1010.17703507119 -0.0711388703652999 0.126728054754183 -0.56135060625123 0.57455854912602 0.737024021221509 1425 Outer membrane protein TolC NA K12340 Drug resistance; Signal transduction; Membrane transport; Infectious diseases; Environmental adaptation Membrane transport 03070 Bacterial secretion system COG1538 M LFTS_01234 280.503730464923 0.11841273774172 0.212011189982674 0.558521169337322 0.576488553058859 0.738931476173116 420 hypothetical protein NA NA NA NA NA NA NA LFTS_01300 186.74790366965 0.116005214193255 0.207783191105585 0.558299319478191 0.576640009563896 0.738931476173116 1374 3-deoxy-D-manno-octulosonic-acid transferase Lipopolysaccharide synthesis K02527 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG1519 M LFTS_00685 1052.08503941542 0.0753123364015761 0.135084272850787 0.55752112967855 0.577171426643441 0.739231409910146 951 Murein DD-endopeptidase MepM and murein hydrolase activator NlpD%2C containing LysM domain NA K08259 NA Folding, sorting and degradation 03060 Protein export NA LFTS_00314 34.8925853505906 -0.182567633181559 0.329235978042603 -0.554519084660714 0.579223648291697 0.741141566582394 1251 EAL domain%2C c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant) c-di-GMP specific phosphodiestereases (EAL domain-containing proteins) K14051 Cellular community - prokaryotes Cellular community - prokaryotes 02024 Quorum sensing COG2199;COG2200;COG2202 T LFTS_02035 18.4750992733491 0.214057340876271 0.386370903391397 0.554020344175425 0.579564922769217 0.741141566582394 180 hypothetical protein NA NA NA NA NA NA NA LFTS_01783 993.618273993688 -0.0720419006202126 0.130123531676059 -0.553642371155126 0.579823622196422 0.741141566582394 939 Nucleoside-diphosphate-sugar epimerase Lipopolysaccharide synthesis K01784 Carbohydrate metabolism Carbohydrate metabolism 00052 Galactose metabolism COG1087 M LFTS_01458 133.1818494228 -0.125389298215261 0.227005894279798 -0.552361420451541 0.580700757157407 0.741141566582394 273 MtN3 and saliva related transmembrane protein NA K15383 NA Cell growth and death 04112 Cell cycle - Caulobacter NA LFTS_02126 595.761782861444 -0.0777322785336453 0.140734051316678 -0.552334547370722 0.580719165235079 0.741141566582394 1032 DNA polymerase-3 subunit delta' NA K02341 Replication and repair; Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0470 L LFTS_01507 205.877927179197 -0.109919921145451 0.199039862059646 -0.55225079040957 0.580776540560293 0.741141566582394 384 general secretion pathway protein I NA K02458 Cellular community - prokaryotes; Membrane transport Membrane transport 03070 Bacterial secretion system COG2165 NUW LFTS_00396 1326.98939344141 0.0754108487436655 0.136631033634063 0.551930602718247 0.580995900498693 0.741141566582394 423 hypothetical protein NA NA NA NA NA NA NA LFTS_01694 830.316611635318 0.0853376387827381 0.15463784602185 0.551854807720743 0.581047833173405 0.741141566582394 882 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase NA K00919 Metabolism of terpenoids and polyketides Metabolism of terpenoids and polyketides 00900 Terpenoid backbone biosynthesis COG1947 I LFTS_00954 615.492644585492 -0.0829567228324479 0.151112571081021 -0.548973008923061 0.58302397298687 0.743280818895056 1092 nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase NA K00768 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG2038 H LFTS_02051 178.968618222022 -0.106780948777901 0.194817031332621 -0.548108900168942 0.583617129720226 0.743655655809576 435 HD domain-containing protein NA K07814 NA Translation 00970 Aminoacyl-tRNA biosynthesis COG3437 T LFTS_00693 12006.7700422066 0.0794127824719591 0.145503593061121 0.54577884161665 0.58521796907249 0.74508581142923 2712 formate dehydrogenase major subunit NA K00336 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG1034 C LFTS_00420 3868.39430325123 -0.110977738012213 0.20340386575589 -0.545602895007904 0.585338933918458 0.74508581142923 414 nitrogen fixation protein NifU Nitrogenase genes K04488 NA Metabolism of cofactors and vitamins 00730 Thiamine metabolism COG0822 O LFTS_01105 44.5718480212511 0.174320497204353 0.320853480774502 0.543302496776921 0.586921545488652 0.746717994925685 708 Methyltransferase domain-containing protein NA K00568 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00130 Ubiquinone and other terpenoid-quinone biosynthesis COG2227 H LFTS_02416 726.794290163633 -0.0800796090413205 0.147668479133321 -0.542293179365797 0.587616553534109 0.747181365489298 507 hypothetical protein NA NA NA NA NA NA NA LFTS_00613 360.639678525736 0.101579987658694 0.187707282169447 0.54116167729175 0.588396149352976 0.747181365489298 309 hypothetical protein NA K09131 NA Overview 01230 Biosynthesis of amino acids COG1872 S LFTS_02168 1712.21475669871 0.0684648863648883 0.126741097799287 0.540194834617199 0.589062674533686 0.747181365489298 1065 site-2 protease. Metallo peptidase. MEROPS family M50B NA K11749 Cellular community - prokaryotes; Cell growth and death Cell growth and death 04112 Cell cycle - Caulobacter COG0750 OK LFTS_01757 1506.99329374531 0.070783783902997 0.131059993740366 0.540086886034971 0.589137114099257 0.747181365489298 750 cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases NA K01420 NA Amino acid metabolism 00260 Glycine, serine and threonine metabolism COG0664 T LFTS_00989 428.446713495155 -0.10124858380686 0.187577275349214 -0.539769988759909 0.589355666313673 0.747181365489298 225 T4 immunity holin family protein NA K05566 NA Membrane transport 03070 Bacterial secretion system COG2111 P LFTS_00750 582.002380157285 -0.0911583391713903 0.168890210214666 -0.539749101238754 0.589370072970376 0.747181365489298 636 hypothetical protein NA K15539 NA Energy metabolism 00190 Oxidative phosphorylation COG1426 D LFTS_01066 310.068402523108 -0.0932769294596584 0.172824435217907 -0.539720724919771 0.589389645102379 0.747181365489298 1011 helix-turn-helix protein NA K07729 NA Translation 03010 Ribosome COG1476 K LFTS_01377 238.50217495533 0.119065429156597 0.221570054943158 0.537371483647202 0.591011036947715 0.748854963227329 1125 acetate kinase NA K00925 Carbohydrate metabolism; Overview; Metabolism of other amino acids; Energy metabolism Overview 01200 Carbon metabolism COG0282 C LFTS_01306 292.768104876653 -0.0961746883890925 0.179893885780288 -0.534618994814279 0.592913346128769 0.750388660991452 753 (heptosyl)LPS beta-1%2C4-glucosyltransferase Lipopolysaccharide synthesis K12984 NA Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG0463 M LFTS_01903 68.3919328158725 0.145304917397714 0.271824416643449 0.534554324412695 0.592958075073451 0.750388660991452 126 hypothetical protein NA NA NA NA NA NA NA LFTS_01621 1486.69933575009 -0.0936291055797913 0.17523364026147 -0.534310109862953 0.593126998732181 0.750388660991452 1473 Outer membrane protein TolC NA K12340 Drug resistance; Signal transduction; Membrane transport; Infectious diseases; Environmental adaptation Membrane transport 03070 Bacterial secretion system COG1538 M LFTS_01797 173.069796907465 0.110820292490573 0.207660587953118 0.533660689218467 0.593576311431606 0.750575132359599 291 Transposase NA K07483 NA Signal transduction 02020 Two-component system COG2963 X LFTS_02444 1317.55875723568 -0.0817736895218515 0.153927584526901 -0.531247792740882 0.59524707808996 0.752305153091836 546 hypothetical protein NA NA NA NA NA NA NA LFTS_00948 2024.46955722075 -0.0846160014507782 0.160084788849886 -0.528569903853413 0.597103842659357 0.7542683703512 1923 molecular chaperone DnaK Chaperones K04043 Aging; Folding, sorting and degradation; Infectious diseases Folding, sorting and degradation 03018 RNA degradation COG0443 O LFTS_01596 535.027101827216 0.0819192435549197 0.155800356376771 0.525796252717259 0.599029778438857 0.756316926967495 447 Response regulator receiver domain-containing protein NA K02485 NA Cellular community - prokaryotes 02024 Quorum sensing COG2197 TK LFTS_01109 359.914208442186 -0.096509084526285 0.183946126358313 -0.524659510025738 0.599819909323176 0.756342576838732 1104 hypothetical protein NA K06871 NA Signal transduction 02020 Two-component system COG0641 O LFTS_01062 99.3919531177662 -0.127078602414477 0.242249576309849 -0.524577191631238 0.59987714577862 0.756342576838732 1014 dTMP kinase NA K00943 Nucleotide metabolism Nucleotide metabolism 00240 Pyrimidine metabolism COG0125 F LFTS_00251 456.063916238217 -0.0793144311529419 0.151232392844326 -0.524453985427484 0.599962816382132 0.756342576838732 483 NitT/TauT family transport system ATP-binding protein NA NA NA NA NA NA NA LFTS_00716 1341.21573393678 0.0805637491420456 0.154034335041415 0.523024617338625 0.600957122263803 0.757084164878226 642 Tetratricopeptide repeat-containing protein NA K12600 Folding, sorting and degradation Folding, sorting and degradation 03018 RNA degradation COG0457 R LFTS_00561 172.492939991016 -0.1079337541615 0.206479749371062 -0.522732880538002 0.601160153447151 0.757084164878226 1098 Mechanosensitive ion channel NA K16052 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0668 M LFTS_00162 896.305482066172 0.0685968290199287 0.131709456750837 0.520819314817291 0.602492646627853 0.757654738053664 1209 hypothetical protein NA K14110 NA Overview 01210 2-Oxocarboxylic acid metabolism COG1863 P LFTS_01096 17.3855451091171 0.212512706757885 0.408382397578669 0.520376754771728 0.602801008386845 0.757654738053664 609 hypothetical protein NA NA NA NA NA NA NA LFTS_00678 2061.94047736063 -0.0784585259447301 0.150920365942013 -0.519867053429196 0.603156240065734 0.757654738053664 1512 Exodeoxyribonuclease VII large subunit NA K03601 Replication and repair Replication and repair 03430 Mismatch repair COG1570 L LFTS_00982 69.6368917883137 -0.140927790218576 0.271272069420167 -0.519507188925876 0.603407101033503 0.757654738053664 1449 hypothetical protein NA NA NA NA NA NA NA LFTS_01780 1158.4517875873 -0.0870581947832123 0.167667573264624 -0.519230958545642 0.603599692608752 0.757654738053664 1047 pyruvate dehydrogenase E1 component beta subunit NA K00162 Carbohydrate metabolism; Overview; Signal transduction; Cancers; Endocrine system Overview 01200 Carbon metabolism COG0022 C LFTS_01249 43.8828264904637 -0.166070598879443 0.319930437250346 -0.519083461726065 0.60370254071011 0.757654738053664 2022 Tetratricopeptide repeat-containing protein putative pel operon K15201 NA Translation 00970 Aminoacyl-tRNA biosynthesis NA LFTS_01145 701.756159568618 0.0801135682956759 0.154463290811694 0.518657655645458 0.603999495334199 0.757654738053664 6510 hypothetical protein NA K03580 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0553 KL LFTS_00865 2488.45877694269 0.0667358937619144 0.128688862525915 0.518583290364194 0.604051363967161 0.757654738053664 516 putative holliday junction resolvase NA K07447 NA Translation 00970 Aminoacyl-tRNA biosynthesis COG0816 K LFTS_01434 535.117763777814 -0.0918362167783584 0.17745979973676 -0.51750434134709 0.604804139155304 0.758216384236049 231 hypothetical protein NA K07143 NA Cell growth and death 04112 Cell cycle - Caulobacter COG1645 R LFTS_02398 768.049852890775 0.082960193278025 0.160505738173238 0.516867460454804 0.605248683877712 0.758391244012093 456 hypothetical protein NA NA NA NA NA NA NA LFTS_00245 166.497235347527 -0.119140990359511 0.230882691995923 -0.516023913830729 0.605837707169046 0.758746871547732 1089 hypothetical protein NA K07286 NA Overview 01200 Carbon metabolism COG3056 S LFTS_01093 3.99833370711272 -0.216475007203086 0.420875894944964 -0.514344037762945 0.607011477787906 0.759834105629775 537 hypothetical protein NA NA NA NA NA NA NA LFTS_01538 388.610430760467 -0.0797334886443324 0.155357525729139 -0.513225788516646 0.607793388620191 0.760429976904779 699 1-acyl-sn-glycerol-3-phosphate acyltransferase NA K00655 Lipid metabolism Lipid metabolism 00561 Glycerolipid metabolism COG0204 I LFTS_00985 655.424784595925 0.0729381242117939 0.142428314847284 0.512104101561551 0.608578154143524 0.760932435463917 1719 AlwI restriction endonuclease NA NA NA NA NA NA NA LFTS_01373 514.333374335445 -0.0735387097507759 0.143692908239028 -0.511776890397727 0.60880716578348 0.760932435463917 720 phosphoribosylaminoimidazole-succinocarboxamide synthase NA K01923 Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0152 F LFTS_00419 3418.01390657144 -0.103609972653974 0.20290576704449 -0.510630989760166 0.609609471768517 0.761552335083685 330 iron-sulfur cluster assembly protein NA K13628 NA Replication and repair 03030 DNA replication COG0316 O LFTS_00372 8209.08862188551 -0.0731191873912239 0.143357891407699 -0.510046476501796 0.610018901498692 0.761681059329858 1044 chlorite dismutase NA K09162 NA Overview 01210 2-Oxocarboxylic acid metabolism COG3253 P LFTS_00297 319.951905411485 0.104454030645795 0.205131013862472 0.509206427048738 0.610607538577191 0.762033303666113 693 haloacid dehalogenase superfamily%2C subfamily IA%2C variant 3 with third motif having DD or ED NA K01838 Carbohydrate metabolism Carbohydrate metabolism 00500 Starch and sucrose metabolism COG0637 GR LFTS_00770 1369.16484359353 0.0746282014059373 0.146831229243388 0.508258371127801 0.611272160127581 0.762479974950912 1476 mannose-1-phosphate guanylyltransferase / mannose-6-phosphate isomerase Extracellular polysaccharide production and export K16011 Carbohydrate metabolism; Cellular community - prokaryotes Carbohydrate metabolism 00051 Fructose and mannose metabolism COG0662;COG0836 GM LFTS_01170 6.70720482865054 0.220003619068735 0.433718807890932 0.507249432272857 0.611979814657411 0.762580763827429 258 4Fe-4S dicluster domain-containing protein NA K03616 NA Metabolism of terpenoids and polyketides 00523 Polyketide sugar unit biosynthesis COG2878 C LFTS_02520 133.518351111616 -0.124174083599283 0.244884045330741 -0.507072983997684 0.612103610054059 0.762580763827429 615 2'-5' RNA ligase NA K01975 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG1514 J LFTS_00813 533.382075969091 0.0973327656300053 0.192065337633075 0.506769034066686 0.612316886070142 0.762580763827429 402 holo-[acyl-carrier protein] synthase NA K00997 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00770 Pantothenate and CoA biosynthesis COG0736 I LFTS_01120 69.4537676854085 0.141745697038909 0.279911783409186 0.506394176452729 0.612579961932171 0.762580763827429 1311 hypothetical protein NA K00795 Metabolism of terpenoids and polyketides Metabolism of terpenoids and polyketides 00900 Terpenoid backbone biosynthesis COG0142 H LFTS_02053 1096.32207834242 -0.0645272160456077 0.127931484307278 -0.504388864047102 0.613988141931685 0.763951211632718 294 hypothetical protein NA K13582 Cell growth and death Cell growth and death 04112 Cell cycle - Caulobacter COG0790;COG3409 TM LFTS_01583 1179.23252652713 0.0747867298356081 0.148866496639409 0.50237448669703 0.615404122264348 0.764747416090226 2178 Glycogen debranching enzyme (alpha-1%2C6-glucosidase) NA K05989 NA Metabolism of cofactors and vitamins 00770 Pantothenate and CoA biosynthesis NA LFTS_02052 30.1712107917218 0.18653314842669 0.371486073426378 0.50212689457296 0.615578262947874 0.764747416090226 123 hypothetical protein NA NA NA NA NA NA NA LFTS_00974 87.1836737223722 0.124735151832219 0.248461764966527 0.502029565188929 0.61564672422653 0.764747416090226 675 type IV secretion system protein VirB5 NA K03203 Membrane transport Membrane transport 03070 Bacterial secretion system COG3736 U LFTS_01097 15.6721337976473 -0.208916474664878 0.416445158471468 -0.501666234833155 0.615902319563091 0.764747416090226 723 hypothetical protein NA NA NA NA NA NA NA LFTS_01467 17.3713461294172 -0.195495130437673 0.390188590269783 -0.501027286068268 0.616351919706942 0.764747416090226 1233 hypothetical protein NA NA NA NA NA NA NA LFTS_00017 136.186534197825 0.114283811532097 0.228177832823963 0.500854136958455 0.616473781916659 0.764747416090226 177 hypothetical protein NA NA NA NA NA NA NA LFTS_00096 437.851954555408 -0.0929209883929416 0.186096568426833 -0.499315969007109 0.617556806979254 0.765652835691656 1044 peptide/nickel transport system ATP-binding protein NA K02032 Cellular community - prokaryotes Cellular community - prokaryotes 02024 Quorum sensing COG1123;COG1124 OEP LFTS_01562 1069.28842152884 0.0964266798477837 0.193261962195193 0.498942879149666 0.617819625260443 0.765652835691656 1674 dihydroxy-acid dehydratase NA K01687 Metabolism of cofactors and vitamins; Amino acid metabolism; Overview Overview 01210 2-Oxocarboxylic acid metabolism COG0129 EG LFTS_00996 444.590781129664 0.0809638885894746 0.162648326901139 0.497784945790964 0.618635627760372 0.766282097963271 525 hypothetical protein NA NA NA NA NA NA NA LFTS_01324 841.683680728743 0.0683689451969713 0.137694359072606 0.496526841458483 0.61952275460435 0.766889813264049 1056 hypothetical protein NA K06865 NA Metabolism of terpenoids and polyketides 00900 Terpenoid backbone biosynthesis COG1855 R LFTS_02020 27.1689545315876 -0.187431964544783 0.377723819774457 -0.49621430985396 0.619743215948301 0.766889813264049 360 hypothetical protein NA K07733 NA Membrane transport 02010 ABC transporters COG3311 KX LFTS_01261 141.512421802142 -0.125264797393265 0.255591671684578 -0.490097335987742 0.624065023124289 0.771853555963672 558 hypothetical protein NA NA NA NA NA NA NA LFTS_01022 32.2005701525961 0.162842602819795 0.333186776302071 0.488742694494453 0.625023873202471 0.77241066375755 279 hypothetical protein NA NA NA NA NA NA NA LFTS_01366 857.462701153769 -0.0689588033263098 0.141140373130922 -0.488583116202645 0.625136868656553 0.77241066375755 720 Thiol-disulfide isomerase or thioredoxin NA K02199 NA Metabolism of cofactors and vitamins 00760 Nicotinate and nicotinamide metabolism COG0526 O LFTS_01527 977.69387616047 -0.074965680268374 0.154002803886983 -0.486781268757862 0.626413345836627 0.773401596203753 720 sugar fermentation stimulation protein A NA K06206 NA Nucleotide metabolism 00230 Purine metabolism COG1489 GT LFTS_00661 721.765486004355 0.0659393733561169 0.135517987503156 0.486572849634306 0.626561067881882 0.773401596203753 1158 putative metallophosphoesterase NA K07098 NA Overview 01210 2-Oxocarboxylic acid metabolism COG1408 R LFTS_01956 1336.41613500749 -0.0616896083288486 0.127249788818038 -0.484791439748965 0.627824295559809 0.774408351280574 1506 anthranilate synthase component 1 NA K01657 Cellular community - prokaryotes; Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG0147 EH LFTS_01965 1748.21173570946 -0.0670993509036315 0.138479314703095 -0.484544215484421 0.627999692752066 0.774408351280574 1089 iron(II)-dependent oxidoreductase NA K13444 Transport and catabolism Transport and catabolism 04142 Lysosome NA LFTS_01968 1079.86347615451 -0.0741979859408782 0.154058267349347 -0.481622876963979 0.630073871781839 0.776580885101463 207 hypothetical protein NA K00407 Energy metabolism; Signal transduction Energy metabolism 00190 Oxidative phosphorylation NA LFTS_02456 8196.37468879067 0.0688087314596095 0.143246801512037 0.480350909991016 0.630977894217778 0.77700811220857 699 pyruvate ferredoxin oxidoreductase gamma subunit Reductive TCA cycle carbon dioxide fixation K00172 Carbohydrate metabolism; Overview; Energy metabolism; Xenobiotics biodegradation and metabolism Overview 01200 Carbon metabolism COG1014 C LFTS_02192 512.67263911377 -0.0906301199026412 0.188738769908545 -0.480188145480428 0.631093615397276 0.77700811220857 960 muramoyltetrapeptide carboxypeptidase NA K01297 NA Carbohydrate metabolism 00630 Glyoxylate and dicarboxylate metabolism COG1619 M LFTS_01920 599.411125155675 -0.0735198349555223 0.153225025678497 -0.47981610464719 0.631358160362555 0.77700811220857 927 aspartate carbamoyltransferase NA K00609 Nucleotide metabolism; Amino acid metabolism Nucleotide metabolism 00240 Pyrimidine metabolism COG0540 F LFTS_01402 621.116339886336 -0.0897211484597953 0.187235726496009 -0.479188187739949 0.631804756783337 0.777172996221364 399 hypothetical protein NA K12193 Transport and catabolism Transport and catabolism 04144 Endocytosis NA LFTS_00192 201.773360239086 -0.0957275793356038 0.201264348391013 -0.475631079726182 0.634337229338827 0.779648907088304 342 hypothetical protein NA NA NA NA NA NA NA LFTS_00889 348.235639446877 0.101269346663102 0.213121300733636 0.475172337605384 0.634664142139955 0.779648907088304 372 hypothetical protein NA NA NA NA NA NA NA LFTS_02505 545.290197773379 -0.0873204732038066 0.183817062860247 -0.475040085207948 0.634758402231186 0.779648907088304 822 Transposase DDE domain group 1 NA NA NA NA NA NA NA LFTS_02315 164.678309704719 0.0977240445425572 0.205963722826699 0.474472121601646 0.635163273556496 0.779760937314296 1368 NADH-quinone oxidoreductase subunit M NADH dehydrogenase K05568 NA Energy metabolism 00190 Oxidative phosphorylation COG0651 CP LFTS_02238 197.360225135125 0.0927110230702994 0.195888681898639 0.47328422536567 0.63601041484628 0.780357178866591 159 hypothetical protein NA NA NA NA NA NA NA LFTS_00615 65.3619013374414 0.136687149601092 0.289145605744598 0.47272774299682 0.636407430930712 0.780357178866591 594 Transposase NA K07488 NA Replication and repair 03410 Base excision repair COG3676 X LFTS_01777 1230.94788379796 0.0878910649120809 0.186136874328304 0.472185133812124 0.636794649929767 0.780357178866591 999 D-glycero-alpha-D-manno-heptose-7-phosphate kinase NA K07031 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG2605 R LFTS_02483 184.736629417574 0.098991885263824 0.209714728503183 0.472031153798153 0.636904551858533 0.780357178866591 732 Peptidase family M50 NA K11749 Cellular community - prokaryotes; Cell growth and death Cell growth and death 04112 Cell cycle - Caulobacter COG0750 OK LFTS_00262 162.818233947815 0.109920929749253 0.234569365711526 0.468607353802689 0.639350319923873 0.782872575016218 789 16S rRNA (cytidine1402-2'-O)-methyltransferase NA K07056 NA Metabolism of other amino acids 00410 beta-Alanine metabolism COG0313 J LFTS_01459 274.157108274263 0.0907063500996295 0.193702833533478 0.468275803946629 0.639587369210755 0.782872575016218 1143 putative secreted hydrolase NA NA NA NA NA NA NA LFTS_00683 1048.04857405029 -0.059843380863087 0.128110408032558 -0.467123489668991 0.640411529254437 0.783487783363174 942 UDP-glucose 4-epimerase Extracellular polysaccharide production and export K01784 Carbohydrate metabolism Carbohydrate metabolism 00052 Galactose metabolism COG1087 M LFTS_01098 12.382887003931 0.19944481316108 0.427358600471131 0.466691937265815 0.640720299105926 0.783487783363174 411 hypothetical protein NA K06930 NA Amino acid metabolism 00310 Lysine degradation COG3413 R LFTS_01966 1028.50136256105 0.0608570025849459 0.13103089525015 0.46444773554179 0.642326996437361 0.785066328978997 558 Cytochrome C and Quinol oxidase polypeptide I NA K00404 Energy metabolism; Signal transduction Energy metabolism 00190 Oxidative phosphorylation COG3278 C LFTS_02448 9283.53882364938 0.0635703598334092 0.13781539511594 0.461271832366257 0.64460359116031 0.787461684336378 582 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit NA NA NA NA NA NA NA LFTS_00486 1022.77700310159 -0.100087482040404 0.219055838953402 -0.456903968041204 0.647740071771165 0.79034479476524 627 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit NA K01704 Amino acid metabolism; Overview; Carbohydrate metabolism Overview 01210 2-Oxocarboxylic acid metabolism COG0066 E LFTS_00477 412.286932984806 0.098137715032946 0.214984582000077 0.456487223967117 0.648039655970217 0.79034479476524 558 peptide-methionine (S)-S-oxide reductase NA K07304 NA Translation 00970 Aminoacyl-tRNA biosynthesis COG0225 O LFTS_02163 1735.17402549 -0.0554847954823008 0.121584544659574 -0.456347438218018 0.648140156313523 0.79034479476524 996 phosphate:acyl-[acyl carrier protein] acyltransferase NA K03621 Lipid metabolism Lipid metabolism 00561 Glycerolipid metabolism COG0416 I LFTS_00529 118.690241810909 -0.109348408349845 0.239828987607739 -0.455943251233222 0.648430786597833 0.79034479476524 1095 Glycosyl transferase family 2 Extracellular polysaccharide production and export K07011 NA Cell motility 02040 Flagellar assembly COG1216 G LFTS_01766 250.997003018597 -0.0949916505486507 0.208745003322071 -0.455060715403515 0.649065559297448 0.79034479476524 423 Toxin FitB NA K07062 NA Amino acid metabolism 00260 Glycine, serine and threonine metabolism COG1487 R LFTS_02479 1539.56409962207 -0.0639779022123756 0.140661046204364 -0.454837383474478 0.649226233457355 0.79034479476524 1023 23S rRNA/1915/1917 synthase NA K06180 NA Folding, sorting and degradation 04120 Ubiquitin mediated proteolysis COG0564 J LFTS_02449 4082.81457106619 -0.0708947454876095 0.156091579008817 -0.454186868617717 0.64969433354413 0.79034479476524 231 hypothetical protein NA NA NA NA NA NA NA LFTS_00553 34.9374154609191 -0.151814698826029 0.334527030592387 -0.453818929242259 0.649959158088703 0.79034479476524 387 PIN domain nuclease%2C a component of toxin-antitoxin system (PIN domain) NA K07064 NA Signal transduction 02020 Two-component system COG1848 R LFTS_01057 46.2694894229124 0.137584724029487 0.303322630443896 0.453592017938586 0.650122499658039 0.79034479476524 477 hypothetical protein NA NA NA NA NA NA NA LFTS_01114 38.9716329228234 0.150561385879094 0.331951974692499 0.453563760295644 0.650142842033353 0.79034479476524 558 hypothetical protein NA K07175 NA Signal transduction 02020 Two-component system COG1875 R LFTS_01019 2624.84446531508 0.0664522375883486 0.146800651523629 0.452669909149911 0.650786450419827 0.790740525778929 333 hypothetical protein NA NA NA NA NA NA NA LFTS_01173 7.934005731746 0.195888116837753 0.433256790296893 0.452129363520234 0.651175791190364 0.790827072251707 792 Leucine rich repeat variant NA NA NA NA NA NA NA LFTS_00746 1495.0706576189 0.109607168537786 0.243196673180081 0.450693535830668 0.652210441909779 0.791696854779155 1647 glucose-6-phosphate isomerase NA K01810 Carbohydrate metabolism; Overview Overview 01200 Carbon metabolism COG0166 G LFTS_01578 1034.68533879033 -0.072985793109076 0.162824461450374 -0.448248331110377 0.653973985587717 0.793450135759426 1041 biotin synthase NA K01012 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00780 Biotin metabolism COG0502 H LFTS_01747 378.926749840755 -0.106939848080455 0.239159920930139 -0.447147865179692 0.654768301102361 0.794026339775839 657 Polyisoprenoid-binding protein YceI NA NA NA NA NA NA NA LFTS_00163 718.271517288217 -0.0719602113157487 0.161198493456341 -0.446407468040254 0.65530293927461 0.794275156723546 846 hypothetical protein NA K09778 NA Overview 01210 2-Oxocarboxylic acid metabolism COG2121 S LFTS_01350 928.063454123438 -0.06628002034927 0.148856151138637 -0.445262220219172 0.656130266736004 0.794275156723546 627 hypothetical protein NA NA NA NA NA NA NA LFTS_01731 1220.34943434893 0.111160965795609 0.249883864913145 0.444850514194851 0.656427786488629 0.794275156723546 945 methyl-accepting chemotaxis protein Chemotaxis K03406 Signal transduction; Cell motility Signal transduction 02020 Two-component system COG0840 NT LFTS_00835 794.171201093781 -0.0710579179487466 0.15991854633223 -0.444338193276996 0.656798091784826 0.794275156723546 465 hypothetical protein NA NA NA NA NA NA NA LFTS_00756 417.099343618637 0.0674317915022952 0.151876943588087 0.443989653131157 0.657050064615676 0.794275156723546 666 hypothetical protein NA K14770 NA Energy metabolism 00190 Oxidative phosphorylation NA LFTS_02043 111.715098976201 -0.116964517325484 0.263661582330097 -0.443616078959305 0.657320178785693 0.794275156723546 1065 cobalt-zinc-cadmium efflux system protein Cadmium/cobalt/zinc resistance K16264 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG1230 P LFTS_01988 2005.13864308193 -0.0539033242212681 0.12152623065957 -0.443553000275855 0.657365792476849 0.794275156723546 1152 lysine 2%2C3-aminomutase NA K01843 Amino acid metabolism Amino acid metabolism 00310 Lysine degradation COG1509 E LFTS_01106 36.5186413999897 0.144412246766519 0.325746812401288 0.443326661286302 0.657529474069613 0.794275156723546 405 hypothetical protein NA NA NA NA NA NA NA LFTS_02029 56.1575697461256 0.136451068391451 0.308622199048674 0.442129791091051 0.658395287733063 0.794546823696247 441 hypothetical protein NA K01507 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG0221 CP LFTS_00584 2844.07259665862 0.0551099230804942 0.124703357729773 0.441928141180571 0.658541206039467 0.794546823696247 687 2Fe-2S iron-sulfur cluster binding domain-containing protein NA K00192 Energy metabolism; Overview Overview 01200 Carbon metabolism COG1152 C LFTS_01018 185.109178124627 0.0876115759393673 0.198355134975857 0.441690485855236 0.658713195349141 0.794546823696247 552 Transglycosylase SLT domain-containing protein NA K08309 NA Amino acid metabolism 00260 Glycine, serine and threonine metabolism COG0741 M LFTS_01151 207.472784526998 -0.0825617799220301 0.187200146694806 -0.44103480354976 0.659187801128885 0.794733692340644 480 leader peptidase (prepilin peptidase) / N-methyltransferase NA K02654 NA Signal transduction 02020 Two-component system COG1989 NU LFTS_01079 53.0034987262653 0.13158038001296 0.299855182461818 0.438813092815943 0.660796972614514 0.796095799048776 1140 hypothetical protein NA K06871 NA Energy metabolism 00190 Oxidative phosphorylation COG0641 O LFTS_01522 388.812801792288 -0.0772892339832623 0.176326516794185 -0.438330180783174 0.661146950724454 0.796095799048776 1212 tyrosyl-tRNA synthetase NA K01866 Translation Translation 00970 Aminoacyl-tRNA biosynthesis COG0162 J LFTS_02102 1004.58684352917 0.0726770866742928 0.166037127394201 0.43771587605069 0.661592259384561 0.796095799048776 366 L-aspartate 1-decarboxylase Proton consuming reactions K01579 Metabolism of cofactors and vitamins; Metabolism of other amino acids Metabolism of other amino acids 00410 beta-Alanine metabolism COG0853 H LFTS_01412 185.64529181726 0.0957370315645186 0.218723892772843 0.437707240625728 0.661598520046167 0.796095799048776 981 hypothetical protein NA K08372 Signal transduction Signal transduction 02020 Two-component system COG0265 O LFTS_02225 390.206711360867 0.099579310474304 0.227741622775466 0.437246864498197 0.661932325843371 0.796112124841132 567 hypothetical protein NA NA NA NA NA NA NA LFTS_01925 614.288209832691 -0.0722273755978194 0.16566010335531 -0.435997407552652 0.662838610495445 0.796816627510482 459 CBS domain-containing protein NA K04767 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0517 T LFTS_00878 855.483999745691 0.0728597380451954 0.167678665377174 0.434520026034952 0.663910855702466 0.797684563840611 639 lipopolysaccharide export system protein LptA NA K09774 NA Translation 03010 Ribosome COG1934 M LFTS_00859 983.942756762325 0.0588088675365024 0.135467297721806 0.434118554998208 0.664202352031402 0.797684563840611 615 hypothetical protein NA NA NA NA NA NA NA LFTS_02474 349.095928427097 0.0695110758535556 0.160375167763014 0.433427922933007 0.664703918548357 0.797901468619611 726 Bacterial regulatory helix-turn-helix protein%2C lysR family NA K03091 NA Folding, sorting and degradation 03060 Protein export NA LFTS_01599 2334.58207072319 0.0890022371898777 0.205557460816944 0.432979843378865 0.665029413395596 0.797906912018075 324 hypothetical protein NA K07164 NA Metabolism of cofactors and vitamins 00730 Thiamine metabolism COG1579 R LFTS_01728 79.1473051848945 -0.110038315641911 0.254410658183713 -0.432522428217024 0.665361754975927 0.797920560960036 564 putative phage-associated protein NA NA NA NA NA NA NA LFTS_01122 78.9570442386397 0.124347042932989 0.287972020674903 0.431802515541488 0.665884951077722 0.797951121312102 1161 hypothetical protein NA NA NA NA NA NA NA LFTS_00671 779.788170324747 -0.060965396848454 0.141253060341287 -0.431604077824247 0.666029194176433 0.797951121312102 1104 protein TonB NA K03832 NA Energy metabolism 00190 Oxidative phosphorylation COG0810 M LFTS_00600 120.423557364271 -0.0960725106838607 0.223387840247075 -0.430070457629211 0.667144389171359 0.798724660440679 489 cell division protein FtsW NA K03588 Cell growth and death Cell growth and death 04112 Cell cycle - Caulobacter COG0772 D LFTS_01250 165.021673276373 0.0913021888351429 0.212596791862688 0.429461743214419 0.667587229113672 0.798724660440679 2193 putative membrane protein-like protein putative pel operon NA NA NA NA NA NA LFTS_02013 31.1791062301646 -0.145688498648427 0.339357525262631 -0.429306815977274 0.667699957220571 0.798724660440679 831 hypothetical protein NA NA NA NA NA NA NA LFTS_01241 49.7170034996288 0.126456595288609 0.294805347738414 0.428949461937225 0.667960003642869 0.798724660440679 756 LuxR family transcriptional regulator Quorum sensing K07782 Cellular community - prokaryotes; Signal transduction Signal transduction 02020 Two-component system COG2771;COG2197 KTK LFTS_00019 149.213234717081 -0.0870133100401536 0.203554047611145 -0.427470301186924 0.669036812158231 0.799297817357793 1671 2-isopropylmalate synthase NA K01649 Amino acid metabolism; Overview; Carbohydrate metabolism Overview 01210 2-Oxocarboxylic acid metabolism COG0119 E LFTS_01121 48.9171808211191 0.130866138684157 0.306331485995105 0.42720433473903 0.669230504342198 0.799297817357793 747 hypothetical protein NA NA NA NA NA NA NA LFTS_01115 28.1668762424861 0.147739134776761 0.346482769597144 0.426396772770366 0.669818752597871 0.799297817357793 354 hypothetical protein NA NA NA NA NA NA NA LFTS_01084 179.382112981213 0.0940812536140923 0.220930265224415 0.425841400762938 0.670223416993835 0.799297817357793 1104 hypothetical protein NA K06871 NA Metabolism of cofactors and vitamins 00730 Thiamine metabolism COG0641 O LFTS_00890 205.755724562269 0.0806557906413326 0.189404781806465 0.425838196227524 0.670225752213599 0.799297817357793 783 hypothetical protein NA NA NA NA NA NA NA LFTS_01178 6.02427849595666 -0.184566069277807 0.433617683085152 -0.425642395311546 0.670368442956958 0.799297817357793 300 NifU-like domain-containing protein Nitrogenase genes K13819 NA Energy metabolism 00190 Oxidative phosphorylation COG0694;COG0822 O LFTS_01081 29.2519873819765 0.152240478302942 0.360516787702791 0.422284019762345 0.672817720867626 0.801833582970718 405 hypothetical protein NA NA NA NA NA NA NA LFTS_01405 325.763600222205 -0.0725866560908397 0.172887702186583 -0.4198485790071 0.674596074086707 0.803567724091784 756 putative phosphoesterase NA K07096 NA Transport and catabolism 04144 Endocytosis COG2129 R LFTS_00949 1219.77633584108 0.0596058592668068 0.14273370765304 0.417601842248068 0.676238249619353 0.805138069230705 1119 molecular chaperone DnaJ NA K03686 NA Folding, sorting and degradation 03018 RNA degradation COG0484 O LFTS_00344 49.7700493820223 0.127225516865894 0.305750061019366 0.416109538757656 0.677329850296566 0.806051703129374 204 hypothetical protein NA NA NA NA NA NA NA LFTS_00714 381.840405437023 -0.0734418759654345 0.176873573048672 -0.415222436566173 0.67797907552747 0.806438268785307 1182 diguanylate cyclase (GGDEF) domain-containing protein Putative diguanylate cyclases (GGDEF domain-containing proteins) K13069 NA Replication and repair 03410 Base excision repair COG2199 T LFTS_02042 58.3233896370084 -0.133017407758198 0.320825195892679 -0.414610228439459 0.678427259209971 0.806442158182177 306 DNA-binding transcriptional regulator%2C ArsR family NA K03892 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0640 K LFTS_00505 1041.50726593349 0.115719655103683 0.279292240532788 0.414331794119779 0.678631132307769 0.806442158182177 1992 alpha-1%2C4-glucan:maltose-1-phosphate maltosyltransferase NA K16147 Carbohydrate metabolism Carbohydrate metabolism 00500 Starch and sucrose metabolism COG0366 G LFTS_01786 912.975409030947 0.0735072718426958 0.178693709360913 0.411359034996754 0.680809287318142 0.808643998219255 819 putative transposase NA K07497 NA Carbohydrate metabolism 00500 Starch and sucrose metabolism COG2801 X LFTS_01653 1096.55825605865 0.0773634027033693 0.188712996721142 0.409952700913799 0.681840644756003 0.809482255426659 333 large subunit ribosomal protein L22 NA K02890 Translation Translation 03010 Ribosome COG0091 J LFTS_00603 978.929110599316 0.0570703174841993 0.139431758379273 0.409306446017561 0.682314785611631 0.809658499775902 852 UDP-N-acetylmuramate dehydrogenase NA K00075 Carbohydrate metabolism; Glycan biosynthesis and metabolism Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG0812 M LFTS_00914 60.9535441540914 -0.118997924336119 0.291604439340822 -0.408079947634257 0.683214981214418 0.810339906154123 648 hypothetical protein NA K02415 NA Replication and repair 03440 Homologous recombination COG1580 N LFTS_01519 90.7990698670535 -0.105161558184614 0.260720755371778 -0.403349392090621 0.686691211023962 0.814074559182437 708 GMP synthase (glutamine-hydrolysing) NA K01951 Xenobiotics biodegradation and metabolism; Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0518;COG0519 F LFTS_01792 94.0344007199842 -0.114533462658512 0.284540273535743 -0.402521095644214 0.687300566215729 0.814082312082519 447 hypothetical protein NA K02315 NA Signal transduction 02020 Two-component system COG1484 L LFTS_00036 225.633442365644 -0.0729220237085836 0.181195119384527 -0.402450264423682 0.687352684256318 0.814082312082519 840 Methyltransferase domain-containing protein NA K02169 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00780 Biotin metabolism COG0500 QR LFTS_00013 419.188450085864 0.0617355952229306 0.153798661847055 0.401405281954426 0.688121761206843 0.814605094457244 291 addiction module antidote protein%2C HigA family NA K07729 NA Membrane transport 02010 ABC transporters COG1476 K LFTS_00792 1132.84632286455 0.0620621688453042 0.155143304473801 0.400031242442593 0.689133505605706 0.815234105227945 996 phosphate starvation-inducible protein PhoH NA K06217 NA Cell growth and death 04112 Cell cycle - Caulobacter COG1702 T LFTS_01717 726.79720054061 0.0695024332431967 0.173998704709029 0.399442245040977 0.689567371581636 0.815234105227945 1002 NADPH2:quinone reductase NA K00344 NA Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG0604 CR LFTS_01094 6.40517313939706 -0.173339131414351 0.434055474909398 -0.399347874717012 0.689636895934983 0.815234105227945 789 hypothetical protein NA NA NA NA NA NA NA LFTS_00415 641.948743816676 -0.0690964849215974 0.173223390264934 -0.398886575397923 0.689976781325723 0.815248231167181 204 FeS assembly protein IscX NA NA NA NA NA NA NA LFTS_01541 111.730025669381 0.116877225979356 0.294523578521479 0.396834869948562 0.691489235021678 0.816341374643299 576 GTP cyclohydrolase I NA K01495 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG0302 H LFTS_01425 270.772280624294 0.0716901704626211 0.180964747131934 0.396155447946746 0.69199035565892 0.816341374643299 1122 CRISPR-associated protein NA NA NA NA NA NA NA LFTS_01764 49.5211825885262 -0.117479558701956 0.296943556618096 -0.395629257088236 0.69237855045137 0.816341374643299 498 Putative restriction endonuclease NA NA NA NA NA NA NA LFTS_02064 149.593113309633 -0.0823854176079941 0.208354538580066 -0.395409757663307 0.692540508998067 0.816341374643299 1098 DNA-binding response regulator%2C OmpR family%2C contains REC and winged-helix (wHTH) domain NA K02483 NA Overview 01200 Carbon metabolism COG0745 TK LFTS_00050 3491.02267803829 -0.0926018036844923 0.234194669301788 -0.395405258200662 0.692543829092002 0.816341374643299 291 hypothetical protein NA NA NA NA NA NA NA LFTS_01187 11.5590087383516 0.166931065105321 0.423335093772542 0.394323710840314 0.693342059798404 0.816894957658215 198 Rop-like protein NA K02660 Cellular community - prokaryotes; Signal transduction Signal transduction 02020 Two-component system COG0840 NT LFTS_00049 859.787168073839 0.0785631727326433 0.199551292180074 0.393699143084217 0.693803174098424 0.817051014120645 639 orotate phosphoribosyltransferase NA K00762 Nucleotide metabolism Nucleotide metabolism 00240 Pyrimidine metabolism COG0461 F LFTS_00852 4206.71777025461 -0.0557802825620901 0.142027824894292 -0.39274193351624 0.694510095700074 0.817496258480295 333 thioredoxin Oxidative stress response K03671 Cardiovascular diseases; Immune system Immune system 04621 NOD-like receptor signaling pathway COG0526 O LFTS_01267 56.7132661102334 0.111642068615806 0.285280379883333 0.391341559000526 0.695544783692699 0.818050855196273 927 hypothetical protein NA K07133 NA Membrane transport 03070 Bacterial secretion system COG1373 R LFTS_02314 393.751160514071 0.0655632180347266 0.167589327706663 0.391213563130249 0.695639383702704 0.818050855196273 3420 hypothetical protein NA K09822 NA Energy metabolism 00190 Oxidative phosphorylation COG3002 S LFTS_01037 46.7174915776222 0.120923300951287 0.311964156558245 0.387619213326868 0.698297848314198 0.820099908496374 633 hypothetical protein NA K07024 Carbohydrate metabolism Carbohydrate metabolism 00500 Starch and sucrose metabolism COG0561 HR LFTS_01229 119.565102133449 0.0852114545846213 0.220030178788791 0.38727166906689 0.698555097106965 0.820099908496374 333 hypothetical protein NA NA NA NA NA NA NA LFTS_00619 378.701921991266 0.0674283653004202 0.17425601044776 0.386950011808255 0.698793215454058 0.820099908496374 699 hypothetical protein NA NA NA NA NA NA NA LFTS_00975 224.196262811419 -0.0713721337337315 0.184757093794699 -0.386302535225195 0.699272623124794 0.820099908496374 1749 Type IV secretory pathway%2C TrbL components NA K07344 Cellular community - prokaryotes Cellular community - prokaryotes 02024 Quorum sensing COG3846 U LFTS_00328 328.026105989821 -0.0660444612191662 0.171010249541337 -0.386201770924858 0.69934724229248 0.820099908496374 219 hypothetical protein NA NA NA NA NA NA NA LFTS_00636 105.410798024427 0.128864279594686 0.333687087150112 0.386182997655869 0.699361144815895 0.820099908496374 354 hypothetical protein NA NA NA NA NA NA NA LFTS_00376 503.533160596025 -0.0682938106046053 0.177501065250747 -0.384751553508312 0.70042149571736 0.820932177495749 1047 DNA polymerase III%2C delta subunit NA K02340 Replication and repair; Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG1466 L LFTS_02452 13738.7006711738 0.0738627239142402 0.192183964833446 0.384333437902858 0.700731327693475 0.820932177495749 891 pyruvate ferredoxin oxidoreductase beta subunit Reductive TCA cycle carbon dioxide fixation K00170 Carbohydrate metabolism; Overview; Energy metabolism; Xenobiotics biodegradation and metabolism Overview 01200 Carbon metabolism COG1013 C LFTS_00981 22.7414424014414 0.143524247339808 0.374075178551195 0.383677548175429 0.701217455321784 0.821114740428618 375 hypothetical protein NA K02171 Drug resistance Drug resistance 01501 beta-Lactam resistance COG3682 K LFTS_02462 834.606603659307 -0.0634568454983919 0.165904699136114 -0.382489741573443 0.702098136568031 0.821758930088571 612 D-sedoheptulose 7-phosphate isomerase NA K03271 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG0279 G LFTS_00025 165.73214850558 -0.0939105034254338 0.246581535037935 -0.380849699110626 0.703314778802368 0.822795548283617 405 8-oxo-dGTP diphosphatase NA K03574 NA Cell growth and death 04112 Cell cycle - Caulobacter COG0494;COG1051 VF LFTS_01468 18.4343210866151 -0.14705795786686 0.386901150335477 -0.380091808306457 0.703877266322338 0.823066267204766 690 hypothetical protein NA NA NA NA NA NA NA LFTS_01317 305.626323176653 0.0655691994276214 0.172897421120734 0.379237579152986 0.704511447998525 0.823348291366385 1170 Glycosyltransferase involved in cell wall bisynthesis Lipopolysaccharide synthesis K13668 NA Cellular community - prokaryotes 02026 Biofilm formation - Escherichia coli COG0438 M LFTS_02241 3523.48345474471 0.0658527419768403 0.173908379018903 0.378663422362659 0.704937818805889 0.823348291366385 1335 ATP-dependent RNA helicase RhlE NA K11927 Folding, sorting and degradation Folding, sorting and degradation 03018 RNA degradation COG0513 L LFTS_02463 694.652241760231 0.051315489645894 0.135601416992268 0.378428859993549 0.705112032308541 0.823348291366385 540 rfaE bifunctional protein%2C domain II NA K03272 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG2870 M LFTS_01075 68.2371754999016 -0.10327542342011 0.274763898329258 -0.375869697759026 0.707013769114062 0.82518132864674 1320 hypothetical protein NA NA NA NA NA NA NA LFTS_02442 1322.15825778168 -0.0683628071948087 0.182421967864663 -0.374750957875459 0.7078456904668 0.82576461121561 855 curved DNA-binding protein NA K05516 NA Amino acid metabolism 00250 Alanine, aspartate and glutamate metabolism COG2214 K LFTS_02419 774.54354711483 0.0688856957951182 0.184095604903527 0.374184358345855 0.708267160373666 0.825868743287492 1212 RND family efflux transporter%2C MFP subunit Cadmium/cobalt/zinc resistance K15727 NA Membrane transport 03070 Bacterial secretion system COG0845 MV LFTS_01606 1317.95765153346 -0.0486045309090719 0.130802731148069 -0.371586514153528 0.71020073141794 0.827735123443506 1176 dTDP-4-amino-4%2C6-dideoxygalactose transaminase NA K13017 Carbohydrate metabolism Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG0399 M LFTS_01345 189.678912792055 0.0696067549908211 0.187773778260344 0.370694756401573 0.710864896310208 0.828120961680964 1089 lipopolysaccharide export system permease protein Lipopolysaccharide synthesis K11720 Membrane transport Membrane transport 02010 ABC transporters COG0795 MN LFTS_00456 114.903525681226 -0.100209623142365 0.272504630168978 -0.367735487944649 0.713070476334449 0.830301266588965 639 hypothetical protein NA NA NA NA NA NA NA LFTS_01558 165.502480688418 0.0771254727623122 0.210321551458523 0.366702661840729 0.713840820819925 0.830809120111579 1110 L-threonine O-3-phosphate decarboxylase NA K04720 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0079 E LFTS_01540 584.812689725489 0.0586924532663303 0.160811499622213 0.364976717487329 0.715128785947579 0.831918653189369 621 5-formyltetrahydrofolate cyclo-ligase NA K01934 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00670 One carbon pool by folate COG0212 H LFTS_01827 3.96928285480494 0.147478101747991 0.406376641184678 0.36290988900853 0.716672199298696 0.833315820512033 339 hypothetical protein NA NA NA NA NA NA NA LFTS_01736 537.732586068959 0.0999247270948214 0.275830500250244 0.362268592502156 0.71715132599884 0.833315820512033 1074 putative oxidoreductase NA K05882 NA Translation 00970 Aminoacyl-tRNA biosynthesis NA LFTS_00794 438.633987846468 0.0562112896125595 0.155270271897302 0.362022226957511 0.717335420714301 0.833315820512033 792 leader peptidase (prepilin peptidase) / N-methyltransferase NA K02654 NA Carbohydrate metabolism 00650 Butanoate metabolism COG1989 NU LFTS_00168 632.464612752627 -0.0566860185663977 0.157496287038894 -0.359919713868549 0.718907174103653 0.834430071379202 876 Aromatic ring-opening dioxygenase%2C catalytic subunit%2C LigB family NA K15777 Biosynthesis of other secondary metabolites Biosynthesis of other secondary metabolites 00965 Betalain biosynthesis NA LFTS_01488 222.519067021439 0.0749801000380976 0.208369972447076 0.359841195722872 0.718965894165024 0.834430071379202 528 5-(carboxyamino)imidazole ribonucleotide mutase NA K11808 Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism NA LFTS_02511 480.128551293111 -0.0539173330723647 0.150337718385646 -0.358641421802452 0.719863355334783 0.83470953370397 618 precorrin-6Y C5%2C15-methyltransferase (decarboxylating) NA K00595 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG2241;COG2242 H LFTS_00843 994.64761050412 0.0521750145181201 0.145487667289985 0.358621562157053 0.719878214103504 0.83470953370397 231 hypothetical protein NA K06960 NA Folding, sorting and degradation 03060 Protein export COG1837 R LFTS_00913 81.486290218631 -0.097517430520326 0.272455258846001 -0.35792089656616 0.720402512100925 0.834928039665687 729 putative mobilization protein%2C MobD NA K03496 NA Membrane transport 02010 ABC transporters COG1192 N LFTS_00983 14.8953307332509 -0.145849603965668 0.408187295774312 -0.357310493186707 0.720859375371775 0.835068223287154 528 conjugative transfer signal peptidase TraF NA K12062 NA Drug resistance 01501 beta-Lactam resistance NA LFTS_00117 1649.23306308298 0.0534186388471823 0.149763227847749 0.356687283085862 0.721325926788664 0.835087043102735 2619 DNA polymerase I NA K02335 Nucleotide metabolism; Replication and repair Nucleotide metabolism 00230 Purine metabolism COG0258;COG0749 L LFTS_00424 704.579756755933 -0.0640701547515696 0.179774683016497 -0.356391421063946 0.721547453171631 0.835087043102735 570 hypothetical protein Extracellular polysaccharide production and export K05790 NA Energy metabolism 00920 Sulfur metabolism COG3765 M LFTS_00187 1421.1036329913 -0.0438881374490299 0.123356298406812 -0.355783515036201 0.722002695470342 0.835189738980279 1134 aminomethyltransferase NA K00605 Carbohydrate metabolism; Metabolism of cofactors and vitamins; Amino acid metabolism; Overview Overview 01200 Carbon metabolism COG0404 E LFTS_00912 36.0168938182832 0.133558752864746 0.375875958831777 0.35532667021282 0.722344877452146 0.835189738980279 384 hypothetical protein NA NA NA NA NA NA NA LFTS_00253 375.969408883852 0.062474684754863 0.176163347508702 0.354640653906607 0.722858815807726 0.835189738980279 921 DNA processing protein NA K04096 NA Energy metabolism 00910 Nitrogen metabolism COG0758 L LFTS_01237 71.7190264158969 -0.0970050870230665 0.273655462931535 -0.354478898334055 0.722980015400467 0.835189738980279 354 hypothetical protein NA K03790 NA Signal transduction 02020 Two-component system COG1670 JO LFTS_01246 84.5852777690979 0.0977934823187273 0.276254958769952 0.35399720154947 0.723340980464949 0.835218614693852 861 Glycoside-hydrolase family GH114 putative pel operon K01884 Translation Translation 00970 Aminoacyl-tRNA biosynthesis COG2342 G LFTS_01059 33.3547732069488 0.116593980317378 0.330015626184387 0.353298362460673 0.723864773045031 0.835303829060564 447 Heavy-metal resistance Metal tolerance NA NA NA NA NA NA LFTS_00294 1358.95268527476 0.0429235514136442 0.12159570301133 0.353002206086548 0.724086786655477 0.835303829060564 462 Response regulator receiver domain-containing protein NA K07713 Signal transduction Signal transduction 02020 Two-component system COG2204 T LFTS_01959 798.794842289252 0.0481445674243207 0.136949199618244 0.351550557130142 0.725175350623982 0.835832438006417 636 putative membrane protein NA K08976 NA Nucleotide metabolism 00230 Purine metabolism COG2322 S LFTS_00647 1605.1192147102 0.0720700135564423 0.205038845478157 0.351494437009596 0.725217445205085 0.835832438006417 939 cysteine synthase NA K01738 Energy metabolism; Amino acid metabolism; Overview Overview 01200 Carbon metabolism COG0031 E LFTS_01614 372.646596215521 -0.0576608142701343 0.164382149381736 -0.3507729670588 0.725758679314099 0.836068617597243 771 ABC-2 type transport system ATP-binding protein NA K09687 NA NA NA NA LFTS_02435 242.431170449185 -0.070303020768716 0.200823849344134 -0.350073066512354 0.726283863343073 0.836286097392719 1077 membrane fusion protein%2C Cu(I)/Ag(I) efflux system Copper/silver resistance K15727 NA Energy metabolism 00910 Nitrogen metabolism COG0845 MV LFTS_00567 846.329797842189 0.0687743857234535 0.196957214955476 0.349184393874581 0.726950881605309 0.836666616514259 3762 AAA ATPase domain-containing protein NA K01768 Cell growth and death; Aging; Cellular community - prokaryotes; Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG2114 T LFTS_02297 2144.79172879619 0.0483869887965233 0.140349111325929 0.344761632898092 0.730273579097978 0.840101859156674 1572 SagB-type dehydrogenase domain-containing protein NA K00353 NA NA NA NA LFTS_00564 838.319776505907 -0.0566993019386816 0.165260332663444 -0.343090813293658 0.731530142088481 0.841158155981482 1905 DNA adenine methylase NA K06223 Replication and repair Replication and repair 03430 Mismatch repair COG0338 L LFTS_01112 11.6107307721947 -0.143768520198565 0.421433816027353 -0.341141395709057 0.73299713907718 0.842113347148781 555 hypothetical protein NA NA NA NA NA NA NA LFTS_01854 305.436634268362 0.0671694244803764 0.197112557042624 0.340766846557887 0.73327911080923 0.842113347148781 1320 L-2-hydroxyglutarate oxidase LhgO NA K15736 NA Biosynthesis of other secondary metabolites 00965 Betalain biosynthesis COG0579 G LFTS_00286 174.693741113942 -0.0737979658970649 0.216647114264837 -0.340636736138805 0.7333770702241 0.842113347148781 303 hypothetical protein NA NA NA NA NA NA NA LFTS_01163 17.6314047841915 -0.134868397754081 0.39660883932466 -0.340053938242358 0.733815908795038 0.842228231424037 1431 Mo-nitrogenase MoFe protein subunit NifD precursor Nitrogenase genes K02586 Energy metabolism; Xenobiotics biodegradation and metabolism Energy metabolism 00910 Nitrogen metabolism COG2710 P LFTS_01068 9.57216605287137 0.147191336908912 0.434130232822646 0.339048805589737 0.734572963750715 0.842405554605266 1050 hypothetical protein NA K03497 NA Translation 03010 Ribosome COG1475 D LFTS_02282 504.95469720075 0.0610521865540539 0.180322599588185 0.338572018668114 0.734932164735194 0.842405554605266 1509 Acyl-CoA reductase NA K00131 Carbohydrate metabolism; Overview Overview 01200 Carbon metabolism COG1012 C LFTS_01841 227.77377503996 -0.14385066458702 0.424965967482276 -0.338499257809438 0.734986986298802 0.842405554605266 1482 Tetratricopeptide repeat-containing protein NA K12284 NA Nucleotide metabolism 00230 Purine metabolism NA LFTS_00296 163.945881917403 -0.071594989711917 0.213307855891042 -0.33564159844393 0.73714115090591 0.84448520790419 534 Carbonic anhydrase or acetyltransferase%2C isoleucine patch superfamily Proton consuming reactions K08279 NA Signal transduction 02020 Two-component system COG0663 R LFTS_00891 105.611811884233 0.0749499660288372 0.225394961668185 0.332527246723353 0.739491169176437 0.846787216293239 405 putative N-acetyltransferase YhbS NA K03824 NA Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG3153 R LFTS_01073 8.3427628614381 -0.143266105442291 0.432443236240421 -0.331294591835494 0.740421975969539 0.847462722035117 411 hypothetical protein NA K06930 NA Energy metabolism 00190 Oxidative phosphorylation COG3413 R LFTS_00075 438.204712459331 0.0675922745332957 0.204612501911383 0.330342837812372 0.741140928062235 0.847895235693841 1425 His Kinase A (phospho-acceptor) domain-containing protein Role of potassium in the internal positive membrane potential K02484 NA Replication and repair 03430 Mismatch repair COG0642 T LFTS_01873 144.382362812371 0.0766370403616845 0.232963137322697 0.32896638173072 0.742181098555346 0.848694669277181 570 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase NA K00995 Lipid metabolism Lipid metabolism 00564 Glycerophospholipid metabolism COG0558 I LFTS_01963 1074.29983208451 -0.0483667873493812 0.147505884936618 -0.327897340300449 0.742989284795808 0.84895748100441 270 hypothetical protein NA K00127 Carbohydrate metabolism; Energy metabolism; Overview Overview 01200 Carbon metabolism COG2864 C LFTS_00676 3040.89255891458 0.0394268789364256 0.120292298175636 0.327758963245171 0.743093917403699 0.84895748100441 1566 ribonucrease Y NA K06950 NA Xenobiotics biodegradation and metabolism 00627 Aminobenzoate degradation COG1418 JR LFTS_02422 2535.83255704371 -0.061570412588543 0.188442340202474 -0.326733432212676 0.743869511575701 0.849453195120438 3174 Multidrug efflux pump subunit AcrB NA K03296 NA Signal transduction 02020 Two-component system COG0841 V LFTS_01992 1032.13527962235 0.0547657576083468 0.167978610622743 0.326028161593403 0.744403048352236 0.849672166301037 945 hydroxymethylbilane synthase NA K01749 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0181 H LFTS_02243 306.910888814794 0.0523743105214505 0.16263450658248 0.322036888862135 0.747424748618065 0.852729658129651 945 glutamate racemase NA K01776 Metabolism of other amino acids Metabolism of other amino acids 00471 D-Glutamine and D-glutamate metabolism COG0796 M LFTS_01143 51.0208500548924 -0.0931482442646393 0.290048653333383 -0.321146963428836 0.748099021980339 0.852896044137241 1197 hypothetical protein NA K03405 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG1239 H LFTS_01353 1919.09354596177 -0.0412206623422657 0.128437753303866 -0.320938830537961 0.748256746686775 0.852896044137241 648 hypothetical protein NA NA NA NA NA NA NA LFTS_02000 278.742879010154 -0.0610828310983646 0.190595672337116 -0.320483830243135 0.748601586095883 0.85289804905333 882 diadenylate cyclase NA K07067 NA Membrane transport 02060 Phosphotransferase system (PTS) COG1623 T LFTS_00481 259.066266302106 0.056264077816262 0.176259557819754 0.319211499859762 0.749566137153592 0.853605779644448 192 Proteolipid membrane potential modulator NA NA NA NA NA NA NA LFTS_00177 485.738098605997 0.0538746347080724 0.17064311947373 0.315715247554216 0.752218652341854 0.856234235220627 831 tRNA (adenine57-N1/adenine58-N1)-methyltransferase NA K07442 NA Cancers 05206 MicroRNAs in cancer COG2519 J LFTS_01031 57.7958258146497 0.0926353318696203 0.295811612279863 0.313156509156846 0.754161758420556 0.858053149397484 414 hypothetical protein NA NA NA NA NA NA NA LFTS_00343 96.0306031312878 -0.0774029583429074 0.248411941370385 -0.311591133324379 0.755351273582092 0.859013387980366 912 cation:H+ antiporter Proton transporters K07301 NA Amino acid metabolism 00260 Glycine, serine and threonine metabolism COG0530 P LFTS_01604 1125.79084384031 -0.0456948575831754 0.147309133026693 -0.310197043756243 0.756411118474968 0.859825350036018 714 dethiobiotin synthetase NA K01935 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00780 Biotin metabolism COG0132 H LFTS_01164 12.4068007907736 -0.128978316832538 0.417171022085896 -0.309173720139127 0.75718938352482 0.860316639599042 1539 Mo-nitrogenase MoFe protein subunit NifK Nitrogenase genes K02591 Energy metabolism; Xenobiotics biodegradation and metabolism Energy metabolism 00910 Nitrogen metabolism COG2710 P LFTS_01574 580.633144425773 0.0434428177825967 0.14224254792798 0.305413664303824 0.760051116035427 0.863173629266364 1167 diaminohydroxyphosphoribosylaminopyrimidine deaminase NA K11752 Cellular community - prokaryotes; Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00740 Riboflavin metabolism COG0117;COG1985 H LFTS_02032 51.901507937193 0.090806623186989 0.298304456242171 0.304409207729938 0.760816153701313 0.86331234688719 798 Type IV secretion-system coupling protein DNA-binding domain-containing protein NA K03205 Membrane transport Membrane transport 03070 Bacterial secretion system COG3505 U LFTS_00265 3613.94652609772 0.0643420985343557 0.211607477777104 0.304063444308571 0.761079556274851 0.86331234688719 288 DNA-binding transcriptional regulator%2C FrmR family NA NA NA NA NA NA NA LFTS_01259 95.2303512087715 0.082201377908935 0.270501088129538 0.303885572059401 0.761215070143492 0.86331234688719 252 prevent-host-death family protein NA NA NA NA NA NA NA LFTS_00113 144.779415229176 0.0662884675363453 0.21992589868883 0.301412739161457 0.763099781298764 0.864902172449128 1002 AAA domain-containing protein NA K03631 NA Glycan biosynthesis and metabolism 00514 Other types of O-glycan biosynthesis COG0497 L LFTS_00500 1326.60418304835 0.0710929968513106 0.236084650729358 0.301133498648372 0.763312697648185 0.864902172449128 1017 Fatty acid desaturase NA K10255 Signal transduction Signal transduction 02020 Two-component system COG3239 I LFTS_00448 434.572150097284 -0.0525074405768341 0.175841064200042 -0.298607386253647 0.76523962903452 0.866582247962914 636 two component transcriptional regulator%2C LuxR family NA K02479 NA Nucleotide metabolism 00230 Purine metabolism COG2197 TK LFTS_00258 512.337749069393 -0.0453751818188174 0.152375000058151 -0.297786262848241 0.765866299831414 0.866582247962914 1335 ATP-dependent HslUV protease ATP-binding subunit HslU Chaperones K03667 NA Translation 03010 Ribosome COG1220 O LFTS_00043 472.626720465109 -0.0519203465821339 0.17499065476172 -0.296703539128032 0.766692854819003 0.866582247962914 879 3-oxoacyl-[acyl-carrier-protein] synthase-3 NA K00648 Overview; Lipid metabolism Overview 01212 Fatty acid metabolism COG0332 I LFTS_01404 152.406516507251 -0.0606924983487517 0.204627423845983 -0.296600021678586 0.766771894316806 0.866582247962914 684 SAM-dependent methyltransferase NA NA NA NA NA NA NA LFTS_01876 332.888272588267 -0.0539125683639771 0.181811516743248 -0.296529996172419 0.766825362822097 0.866582247962914 870 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) NA K01627 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG2877 M LFTS_00435 82.6214740413168 -0.0727932273133368 0.245550304792705 -0.296449346193194 0.766886945099924 0.866582247962914 687 Fic/DOC family protein NA K04095 NA Overview 01210 2-Oxocarboxylic acid metabolism COG2184 T LFTS_02376 611.454965482944 -0.0549404795643119 0.18586663234747 -0.295590870025573 0.767542546896093 0.866929019347427 1209 Zn-dependent protease (includes SpoIVFB) NA K06402 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG1994 O LFTS_00951 304.150671664103 -0.0503574821693395 0.171178384753658 -0.294181314082433 0.768619358427672 0.867751010468298 447 RDD family protein NA NA NA NA NA NA NA LFTS_01550 1020.06550004114 0.0427627777657474 0.146430380718951 0.292034873881967 0.770259960093081 0.869208470627053 999 3'-5' exoribonuclease NA K03698 NA Overview 01200 Carbon metabolism COG3481 J LFTS_00952 632.270261055142 0.0404987794638355 0.138992083135349 0.291374721137162 0.770764745814932 0.869383465560763 606 Thiopurine S-methyltransferase (TPMT) NA K00569 Xenobiotics biodegradation and metabolism Xenobiotics biodegradation and metabolism 00983 Drug metabolism - other enzymes COG0500 QR LFTS_00176 235.825661263205 0.0567876010569138 0.195881094631529 0.289908534377638 0.771886212396722 0.870253570983334 645 Methyltransferase domain-containing protein NA K00568 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00130 Ubiquinone and other terpenoid-quinone biosynthesis COG2227 H LFTS_02179 408.730312620242 -0.0498160429494601 0.173533473536013 -0.287068782375995 0.774059654669011 0.8720958316583 648 tRNA threonylcarbamoyladenosine biosynthesis protein TsaB NA K14742 NA Energy metabolism 00910 Nitrogen metabolism COG1214 J LFTS_01309 728.727058073283 0.0556245601594842 0.193910438919699 0.286856965872369 0.774221842505981 0.8720958316583 819 Proline 4-hydroxylase (includes Rps23 Pro-64 3%2C4-dihydroxylase Tpa1)%2C contains SM-20 domain NA K07394 NA Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG3751 JO LFTS_01894 824.005908587207 -0.0397220142012965 0.138948355405341 -0.285876101846756 0.774973018189148 0.872546613776368 468 hypothetical protein NA NA NA NA NA NA NA LFTS_01706 3360.83915761723 -0.0467633660245882 0.164061127799546 -0.285036234065908 0.775616382075693 0.872875656785954 2034 transketolase NA K00615 Carbohydrate metabolism; Energy metabolism; Overview; Metabolism of terpenoids and polyketides Overview 01200 Carbon metabolism COG0021 G LFTS_00863 3865.15419289087 -0.0423388271088542 0.14930914384552 -0.283564864270197 0.776743866484322 0.873294360865648 2676 alanyl-tRNA synthetase NA K01872 Translation Translation 00970 Aminoacyl-tRNA biosynthesis COG0013 J LFTS_02087 60.5048186897452 0.0824910098102712 0.291275118047447 0.283206510611847 0.777018537833692 0.873294360865648 1275 OmpA family protein NA NA NA NA NA NA NA LFTS_01222 828.609702943366 -0.0453314761700083 0.160093699211352 -0.283155904281796 0.777057328882432 0.873294360865648 1002 hypothetical protein NA NA NA NA NA NA NA LFTS_01622 983.968569243887 -0.0562089969650246 0.198816987164067 -0.282717275655324 0.777393572242831 0.873294360865648 714 transcriptional regulator%2C TetR family NA K09017 NA Nucleotide metabolism 00230 Purine metabolism COG1309 K LFTS_01625 661.43005296572 -0.0482802999985225 0.171627322232229 -0.281308939454258 0.778473454358768 0.873896470015176 768 phosphoribosylformylglycinamidine synthase NA K01952 Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0046;COG0047 F LFTS_00597 280.512359902396 0.0481714547417907 0.171366816344996 0.281101416068861 0.778632615077882 0.873896470015176 1074 Phospho-N-acetylmuramoyl-pentapeptide- transferase NA K01000 Glycan biosynthesis and metabolism; Drug resistance Glycan biosynthesis and metabolism 00550 Peptidoglycan biosynthesis COG0472 M LFTS_01087 4.28640992205334 -0.114356557550272 0.410320957459103 -0.278700260055984 0.780474862920839 0.874958930313053 267 hypothetical protein NA NA NA NA NA NA NA LFTS_02533 279.005106975697 -0.0484696015954046 0.174187781188301 -0.278260629217199 0.780812296380021 0.874958930313053 237 hypothetical protein NA K02498 NA Lipid metabolism 00564 Glycerophospholipid metabolism COG3071 S LFTS_01983 778.138116019786 -0.0466156854604396 0.167609236416711 -0.278121220864842 0.780919306238361 0.874958930313053 195 hypothetical protein NA NA NA NA NA NA NA LFTS_02060 18.1383562391295 0.110681337091954 0.398610829652112 0.277667661936207 0.781267486793607 0.874958930313053 705 biopolymer transport protein ExbB NA K03561 NA Replication and repair 03440 Homologous recombination COG0811 U LFTS_00924 5375.97555664242 0.0563581131675188 0.203279752030882 0.277244106235219 0.781592674569496 0.874958930313053 1068 Site-specific recombinase XerD NA K04763 NA Translation 00970 Aminoacyl-tRNA biosynthesis COG0582 LX LFTS_00485 240.887786049337 0.0593312779950747 0.214102625339738 0.277116069459343 0.781690983196014 0.874958930313053 1089 putative PurR-regulated permease PerM NA K06143 NA Metabolism of terpenoids and polyketides 00523 Polyketide sugar unit biosynthesis COG4452 V LFTS_01525 401.052919871624 -0.0464170825276063 0.168878971713522 -0.274854128116945 0.783428310688538 0.876275050959293 1050 hypothetical protein NA K07027 NA Translation 00970 Aminoacyl-tRNA biosynthesis COG0392 S LFTS_01378 193.245937575772 -0.0577738867244547 0.210539490974337 -0.274408788855184 0.783770489622306 0.876275050959293 675 Ubiquinone/menaquinone biosynthesis C-methylase UbiE NA K03183 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00130 Ubiquinone and other terpenoid-quinone biosynthesis COG2226 H LFTS_00345 478.681672305719 0.0608322498978507 0.222152363630596 0.273831207121456 0.784214340085235 0.876275050959293 462 hypothetical protein NA NA NA NA NA NA NA LFTS_01016 64.1200916225899 0.0767984463863859 0.281183647147075 0.273125578836439 0.78475668490762 0.876275050959293 711 hypothetical protein NA NA NA NA NA NA NA LFTS_01257 13.8642239004358 0.111496625878894 0.408506376957846 0.27293729588559 0.784901416574127 0.876275050959293 363 hypothetical protein NA NA NA NA NA NA NA LFTS_01144 34.7016571853525 -0.0907280700265655 0.332540868216779 -0.272832841608572 0.784981712987267 0.876275050959293 816 hypothetical protein NA NA NA NA NA NA NA LFTS_02299 63.7592066690645 -0.0792490111913678 0.291376360707903 -0.271981608250001 0.785636160952546 0.876611982104142 714 DNA replication and repair protein RadC NA K03630 NA Membrane transport 02010 ABC transporters COG2003 L LFTS_01751 26.8487617818642 -0.0950055918839584 0.352278221032253 -0.26968908723784 0.7873994567011 0.878185307025094 963 Formate hydrogenlyase subunit 4 NA K12138 NA Amino acid metabolism 00260 Glycine, serine and threonine metabolism COG0650 C LFTS_00744 49.6402544116536 -0.0785048909722605 0.292456327557274 -0.268432868688356 0.788366142015316 0.878206030294384 540 Rad51 protein NA K04483 NA Overview 01200 Carbon metabolism COG0468 L LFTS_00715 1479.13761874611 -0.0599507162232718 0.22341882700808 -0.268333322782613 0.788442758541955 0.878206030294384 321 hypothetical protein NA NA NA NA NA NA NA LFTS_01684 918.263095298759 -0.0381748729568124 0.142290768611378 -0.26828776968009 0.788477819636792 0.878206030294384 693 rare lipoprotein A NA K03642 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0797 M LFTS_00009 4967.24310797065 0.0442161769976949 0.165413170279234 0.26730747571704 0.789232431339427 0.878652854594633 492 SsrA-binding protein NA K03664 NA Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG0691 O LFTS_00094 758.679915030896 0.0449842538616915 0.169078170483109 0.266055953486825 0.790196116738515 0.879331936531759 1710 phenylalanyl-tRNA synthetase beta subunit NA K01890 Translation Translation 00970 Aminoacyl-tRNA biosynthesis COG0072 J LFTS_02514 902.966025999948 0.0425669339663841 0.160297940713291 0.265548850951986 0.790586682516395 0.87937292739855 540 cob(I)alamin adenosyltransferase NA K00798 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG2096 H LFTS_02491 1565.20067895487 -0.0413397923094266 0.156304734482465 -0.264482022545929 0.791408515697454 0.879524763473539 330 ferredoxin%2C 2Fe-2S NA K04755 NA Folding, sorting and degradation 04122 Sulfur relay system COG0633 C LFTS_02115 208.347434795673 -0.0603182712927618 0.228204048850577 -0.264317270427821 0.791535453483093 0.879524763473539 453 putative oxidoreductase NA K15977 NA Amino acid metabolism 00270 Cysteine and methionine metabolism COG2259 S LFTS_00641 10.8068612590833 0.111189785573292 0.421183043331599 0.263993974433943 0.791784561807635 0.879524763473539 216 hypothetical protein NA NA NA NA NA NA NA LFTS_01284 153.4061815711 -0.063178071971262 0.241523925768405 -0.261581008052357 0.793644487698054 0.881197050655365 393 mRNA interferase MazF NA K07171 NA Amino acid metabolism 00270 Cysteine and methionine metabolism COG2337 V LFTS_01314 682.218513103763 0.0391542183602326 0.151760551523963 0.257999974084505 0.796406927225304 0.883869473697368 1002 ADP-heptose:LPS heptosyltransferase Lipopolysaccharide synthesis K02843 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG0859 M LFTS_02079 1637.75818643763 -0.0354542388464568 0.138292581661369 -0.256371227006753 0.797664203108309 0.8842850164327 624 sugar ABC transporter substrate-binding protein NA NA NA NA NA NA NA LFTS_02128 1451.327731025 -0.0408734198643411 0.159853270908622 -0.255693359491567 0.798187623121044 0.8842850164327 2022 methionyl-tRNA synthetase NA K01874 Translation; Metabolism of other amino acids Metabolism of other amino acids 00450 Selenocompound metabolism COG0143 J LFTS_00789 615.123162679949 0.0406195687669825 0.159071985706874 0.255353377192596 0.798450176944138 0.8842850164327 930 fused signal recognition particle receptor NA K03110 Cellular community - prokaryotes; Folding, sorting and degradation; Membrane transport Folding, sorting and degradation 03060 Protein export COG0552 U LFTS_01312 1340.8544558916 -0.0365105874823617 0.143157530338935 -0.255037841152473 0.798693872360331 0.8842850164327 600 D-glycero-D-manno-heptose 1%2C7-bisphosphate phosphatase Lipopolysaccharide synthesis K03273 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG0241 E LFTS_00870 357.516920221222 -0.0473831597887763 0.185823370714312 -0.254990314763066 0.798730579735036 0.8842850164327 780 type III pantothenate kinase NA K03525 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00770 Pantothenate and CoA biosynthesis COG1521 H LFTS_00334 1463.41336608133 -0.0410214060595621 0.161025629059166 -0.25475078904669 0.79891558604499 0.8842850164327 477 peroxiredoxin Q/BCP Oxidative stress response K03564 NA Folding, sorting and degradation 03050 Proteasome COG1225 O LFTS_01727 25.3786996928862 0.0998431236518701 0.394325990147897 0.253199449558024 0.800114091848159 0.88447060409713 216 hypothetical protein NA NA NA NA NA NA NA LFTS_01061 98.3055231514073 0.0633921698856246 0.250447576694626 0.253115525102163 0.800178942136018 0.88447060409713 1191 diguanylate cyclase (GGDEF) domain-containing protein Putative diguanylate cyclases (GGDEF domain-containing proteins) K13590 Cell growth and death Cell growth and death 04112 Cell cycle - Caulobacter COG2199 T LFTS_01063 60.4801002644167 0.0689234712815575 0.272585806548681 0.252850550636607 0.800383702819765 0.88447060409713 495 hypothetical protein NA NA NA NA NA NA NA LFTS_02030 40.4177550941988 -0.081993804488013 0.324566344674454 -0.252625713766639 0.800557457684153 0.88447060409713 246 hypothetical protein NA NA NA NA NA NA NA LFTS_01206 20.8391475936569 -0.100943118171112 0.400200343429975 -0.252231463136599 0.800862160025197 0.88447060409713 279 Plasmid maintenance system killer protein NA K07334 NA Translation 00970 Aminoacyl-tRNA biosynthesis COG3549 V LFTS_01392 404.079278613825 0.0512310608315852 0.204061316725384 0.251057190327403 0.801769893230938 0.885079908779801 915 Nucleoside-diphosphate-sugar epimerase NA K01784 Carbohydrate metabolism Carbohydrate metabolism 00052 Galactose metabolism COG1087 M LFTS_02401 2001.48409459992 0.0317668561311722 0.12766995305137 0.248820144222896 0.803499908224781 0.886595992830362 1581 RNAse G NA K08301 NA Glycan biosynthesis and metabolism 00550 Peptidoglycan biosynthesis COG1530 J LFTS_00374 677.301914665889 -0.0364220681859978 0.148049049972923 -0.246013521820364 0.805671765227012 0.888598051621274 1635 putative peptidoglycan lipid II flippase NA K03980 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00550 Peptidoglycan biosynthesis COG0728 M LFTS_02220 183.981479264824 -0.051745264669874 0.213332070712968 -0.242557363723787 0.808348313712659 0.891154726336883 342 putative addiction module killer protein NA NA NA NA NA NA NA LFTS_00042 658.259942603932 -0.0352336219366468 0.146043429901775 -0.24125441288488 0.809357940676233 0.891872269734537 1374 two-component system%2C NtrC family%2C nitrogen regulation response regulator NtrX Nitrate/nitrite regulation K13599 Signal transduction Signal transduction 02020 Two-component system COG2204 T LFTS_01113 6.80240266870969 -0.103770170655904 0.434117536484756 -0.239037039360763 0.81107686184684 0.89245164463436 192 hypothetical protein NA NA NA NA NA NA NA LFTS_02062 35.6041625618662 0.0818440635522038 0.34257661807464 0.238907325351585 0.811177445212467 0.89245164463436 651 protein TonB NA K03832 NA Replication and repair 03440 Homologous recombination COG0810 M LFTS_01252 34.7640910860405 -0.0845969596165624 0.354376189076245 -0.238720778156912 0.811322103862872 0.89245164463436 384 hypothetical protein NA K06996 NA Overview 01210 2-Oxocarboxylic acid metabolism COG3324 R LFTS_01623 986.114813496855 -0.0486326190949038 0.203912730878618 -0.238497218321563 0.811495472576 0.89245164463436 729 hypothetical protein NA NA NA NA NA NA NA LFTS_02352 795.262022042564 0.0339318439313654 0.142869556935633 0.237502268916902 0.812267159212029 0.89245164463436 888 4-hydroxy-tetrahydrodipicolinate synthase NA K01714 Amino acid metabolism; Overview; Biosynthesis of other secondary metabolites Overview 01230 Biosynthesis of amino acids COG0329 EM LFTS_02453 19353.6418922309 -0.0473528470875135 0.199506666899287 -0.237349697749287 0.812385510149575 0.89245164463436 1221 pyruvate ferredoxin oxidoreductase alpha subunit Reductive TCA cycle carbon dioxide fixation K00169 Carbohydrate metabolism; Overview; Energy metabolism; Xenobiotics biodegradation and metabolism Overview 01200 Carbon metabolism COG0674 C LFTS_01124 367.785348574132 0.041080037398113 0.17308858376149 0.237335337232407 0.812396649962814 0.89245164463436 2526 Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB NA K02454 Cellular community - prokaryotes; Membrane transport Membrane transport 03070 Bacterial secretion system COG2804 NUW LFTS_01374 303.635525185473 0.039339827505441 0.166629346494285 0.236091830959621 0.813361412729783 0.892762763542813 297 phosphoribosylformylglycinamidine synthase NA NA NA NA NA NA NA LFTS_00903 1178.72269686337 -0.0337247693382003 0.142874588355749 -0.23604455996211 0.813398093091099 0.892762763542813 903 methylthioadenosine phosphorylase NA K00772 Amino acid metabolism Amino acid metabolism 00270 Cysteine and methionine metabolism COG0005 F LFTS_01167 3.62107026169891 -0.0974201892181932 0.415717779756705 -0.234342128150515 0.814719382764657 0.89381835196511 399 nitrogen fixation protein NifX Nitrogenase genes K02596 NA Energy metabolism 00910 Nitrogen metabolism NA LFTS_01360 2517.86372393078 0.0380713625503681 0.16284204576398 0.233793197400308 0.815145530931636 0.893891393866805 297 integration host factor subunit alpha NA K04764 NA Nucleotide metabolism 00230 Purine metabolism COG0776 L LFTS_00925 490.568597254517 -0.0359396665221507 0.154347166757679 -0.232849538330528 0.815878243964121 0.894300403216404 969 hypothetical protein NA K09958 NA Translation 00970 Aminoacyl-tRNA biosynthesis COG3558 S LFTS_01168 5.66050952160832 -0.0996833992621051 0.430196656573512 -0.231715885604683 0.816758692226382 0.894870916207486 459 putative nitrogen fixation protein Nitrogenase genes NA NA NA NA NA NA LFTS_01152 176.265289535521 0.0469834650546317 0.20526138081831 0.228895785789435 0.818949916078633 0.896656137219374 900 hypothetical protein NA NA NA NA NA NA NA LFTS_02091 10.6799964231125 -0.0967461195008331 0.424812247060138 -0.227738536660261 0.819849511615493 0.896656137219374 366 hypothetical protein NA NA NA NA NA NA NA LFTS_01547 241.473356792587 -0.0430157919904516 0.188891621039526 -0.227727369555744 0.819858193597621 0.896656137219374 861 acyl-[acyl-carrier-protein] desaturase NA K03921 Lipid metabolism; Overview Overview 01212 Fatty acid metabolism NA LFTS_01579 595.437810167863 0.0382964920712735 0.168432520077027 0.227369940518375 0.820136092195873 0.896656137219374 900 6-carboxyhexanoate--CoA ligase NA K01906 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00780 Biotin metabolism COG1424 H LFTS_01389 1217.25588926345 0.0549202555553662 0.241992749628272 0.226950004244878 0.820462618589613 0.896656137219374 2367 xylulose-5-phosphate/fructose-6-phosphate phosphoketolase NA K01632 NA NA NA NA LFTS_02464 1588.53313299281 0.0297320769192766 0.131374591649877 0.226315275624337 0.82095621835289 0.896656137219374 3465 transcription-repair coupling factor NA K03723 Replication and repair Replication and repair 03420 Nucleotide excision repair COG1197 LK LFTS_02210 117.435797848499 0.0519358909945583 0.229609141212834 0.226192610277727 0.821051617831346 0.896656137219374 279 hypothetical protein NA NA NA NA NA NA NA LFTS_00045 410.074146424419 0.0462059086654814 0.204534843925283 0.225907272221844 0.821273541612435 0.896656137219374 654 precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase NA K02304 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG1648 H LFTS_01103 28.7180215589595 0.0798155556930203 0.354235093237176 0.225318036571775 0.821731869246854 0.896762698396698 651 hypothetical protein NA NA NA NA NA NA NA LFTS_00377 405.92016924966 -0.0396363384306632 0.176628096612413 -0.224405625100744 0.82244169410124 0.89691952872402 720 Lipopolysaccharide-assembly NA K03643 NA Folding, sorting and degradation 03018 RNA degradation COG2980 M LFTS_00058 219.583050364867 -0.0474414266517072 0.211905641824941 -0.223879960170666 0.822850709430572 0.89691952872402 1023 peptide/nickel transport system permease protein NA K02034 Cellular community - prokaryotes Cellular community - prokaryotes 02024 Quorum sensing COG1173 EP LFTS_00033 318.716776705819 -0.0404062408090742 0.181417396304386 -0.222725282316806 0.823749323122873 0.89691952872402 507 hypothetical protein NA NA NA NA NA NA NA LFTS_00123 680.979262563103 -0.0421937371000208 0.189475220975425 -0.222687361876692 0.823778838160338 0.89691952872402 1008 thiamine-monophosphate kinase NA NA NA NA NA NA NA LFTS_01355 941.948744444184 0.0327819599056543 0.147245995441521 0.222633965747976 0.823820398985013 0.89691952872402 1062 threonine synthase NA K01733 Metabolism of cofactors and vitamins; Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG0498 E LFTS_02201 1318.54210364563 -0.0404768158066511 0.182039814742258 -0.222351444731804 0.824040307162375 0.89691952872402 1272 hypothetical protein NA K09908 NA Translation 03010 Ribosome COG3105 S LFTS_01714 675.477177664336 0.0364076804927351 0.164100435312671 0.221862181068351 0.824421171961014 0.896941371332639 957 HD-like signal output (HDOD) domain%2C no enzymatic activity NA K07181 Cellular community - prokaryotes Cellular community - prokaryotes 05111 Biofilm formation - Vibrio cholerae COG2200;COG3434 T LFTS_00007 361.726560775996 -0.0390657454071502 0.177652496004979 -0.219899783485481 0.825949204938751 0.897898532196409 726 7-cyano-7-deazaguanine synthase NA K06920 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG0603 J LFTS_01820 5.29734744326203 -0.0943368402018774 0.430703121124035 -0.219029850435446 0.826626794995562 0.897898532196409 300 hypothetical protein NA NA NA NA NA NA NA LFTS_02221 207.501284125975 0.0532998398060493 0.243381473904238 0.218997111616724 0.826652297755665 0.897898532196409 282 putative addiction module antidote protein NA K15773 NA Lipid metabolism 00564 Glycerophospholipid metabolism COG1396 K LFTS_00909 1603.16853221927 0.0326497144497553 0.149420287357339 0.218509246817827 0.82703235446521 0.897898532196409 1239 hypothetical protein NA K07729 NA Carbohydrate metabolism 00030 Pentose phosphate pathway COG1476 K LFTS_00506 572.612788045067 0.0510439345505546 0.233703073875631 0.218413620771281 0.827106853873603 0.897898532196409 1572 maltose alpha-D-glucosyltransferase/ alpha-amylase NA K16146 Carbohydrate metabolism Carbohydrate metabolism 00500 Starch and sucrose metabolism COG3281 G LFTS_01221 205.779707838053 -0.0425631377841255 0.196298933341354 -0.216828166407356 0.82834226048032 0.898847166981264 246 hypothetical protein NA NA NA NA NA NA NA LFTS_00112 117.194907245428 0.0518294112104619 0.240264629086464 0.21571802477763 0.829207550257181 0.899393529641951 912 DNA-binding transcriptional regulator%2C LysR family NA K11921 NA Glycan biosynthesis and metabolism 00514 Other types of O-glycan biosynthesis COG0583 K LFTS_00825 270.762108659965 0.0407125556985488 0.189458129945341 0.214889462438453 0.829853500738494 0.899701614843392 387 2-iminobutanoate/2-iminopropanoate deaminase NA K07567 NA NA NA NA LFTS_02385 360.838955988503 -0.0444299614427073 0.207400936866119 -0.214222568682935 0.830373497318124 0.89987293562897 768 phospholipid/cholesterol/gamma-HCH transport system permease protein NA K02066 Membrane transport Membrane transport 02010 ABC transporters COG0767 M LFTS_02266 528.05639092115 -0.0426752911927233 0.201365389645852 -0.211929623396442 0.832161939353161 0.901350919912333 636 glutamine amidotransferase NA K02501 Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG0118 E LFTS_01089 28.7963168983585 0.0725337237584291 0.343516714301319 0.211150493523892 0.832769840191612 0.901350919912333 1137 ERF superfamily protein NA NA NA NA NA NA NA LFTS_02403 1782.45979836343 0.0383271023566825 0.181875000230337 0.210733208567109 0.833095459764685 0.901350919912333 1935 penicillin-binding protein 2 NA K05515 Drug resistance; Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00550 Peptidoglycan biosynthesis COG0768 DM LFTS_01919 710.965540668195 -0.0309407183066847 0.146906446856793 -0.210615115733118 0.833187616234329 0.901350919912333 1317 dihydroorotase NA K01465 Nucleotide metabolism Nucleotide metabolism 00240 Pyrimidine metabolism COG0044;COG0418 F LFTS_01481 349.17772787313 -0.0472687031399532 0.225060512530539 -0.210026639540063 0.833646881365012 0.901455479370778 504 putative transposase NA K07496 NA Carbohydrate metabolism 00500 Starch and sucrose metabolism COG0675 X LFTS_00980 56.7323534364175 0.0590070780236221 0.284264146270974 0.207578334438891 0.835558222496835 0.902840160896792 999 type IV secretion system protein VirB11 NA K03196 Infectious diseases; Membrane transport Membrane transport 03070 Bacterial secretion system COG0630 U LFTS_01549 1084.10019911874 -0.0350351296032406 0.168879801471256 -0.20745600893665 0.835653745061753 0.902840160896792 2838 FAD/FMN-containing dehydrogenase NA K00102 Carbohydrate metabolism Carbohydrate metabolism 00620 Pyruvate metabolism NA LFTS_00186 295.083776140261 -0.0381171538651051 0.184317690690067 -0.20680138581597 0.83616497382284 0.902880500311381 186 hypothetical protein NA NA NA NA NA NA NA LFTS_02088 21.5730542226549 0.0822817317226692 0.398500974027861 0.206478119466068 0.836417454632787 0.902880500311381 381 hypothetical protein NA NA NA NA NA NA NA LFTS_01326 759.232579697684 0.0332200132653368 0.161996531430138 0.205066200936921 0.837520402986113 0.903678698708107 705 serine O-acetyltransferase NA K00640 Energy metabolism; Amino acid metabolism; Overview; Cellular community - prokaryotes Overview 01200 Carbon metabolism COG1045 E LFTS_00490 357.814480364084 -0.0351838959648301 0.173253214168528 -0.203077883049291 0.839074158307982 0.904962411086179 552 dTDP-4-dehydrorhamnose 3%2C5-epimerase Extracellular polysaccharide production and export K01790 Biosynthesis of other secondary metabolites; Metabolism of terpenoids and polyketides Metabolism of terpenoids and polyketides 00523 Polyketide sugar unit biosynthesis COG1898 M LFTS_02072 214.348337319478 -0.0837487305627224 0.418018211698552 -0.200347085889924 0.841209139745827 0.906871605120609 3129 multidrug efflux pump NA K03296 NA Membrane transport 02010 ABC transporters COG0841 V LFTS_01082 34.1542042041005 -0.0672728606470974 0.338609115784476 -0.198674097982396 0.842517686915751 0.907888586767472 696 hypothetical protein NA K06871 NA Metabolism of cofactors and vitamins 00730 Thiamine metabolism COG0641 O LFTS_01078 27.4398779671385 0.0689345678807111 0.347962913362343 0.198108951366687 0.842959821458162 0.907971454135611 651 hypothetical protein NA NA NA NA NA NA NA LFTS_01400 636.579365470243 -0.0304860833777907 0.155150256866617 -0.19649392784441 0.844223584909544 0.908938861881822 1668 sulfate-transporting ATPase NA K06020 NA Transport and catabolism 04144 Endocytosis NA LFTS_01571 408.864458191093 0.0337682575978993 0.173326681258177 0.194824347600587 0.845530460875584 0.909372768770979 756 precorrin-2/cobalt-factor-2 C20-methyltransferase NA K03394 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG2243 H LFTS_01912 11256.8649531477 -0.0352270738044212 0.18093005012302 -0.194699961562323 0.845627842004123 0.909372768770979 324 iron-sulfur cluster insertion protein NA K15724 NA Nucleotide metabolism 00240 Pyrimidine metabolism COG0316 O LFTS_01539 736.718523439394 -0.027007493824654 0.138800951137617 -0.19457715241358 0.845723990908489 0.909372768770979 1902 Citrate transporter NA K14445 NA Lipid metabolism 00561 Glycerolipid metabolism COG0471 G LFTS_01235 242.909441399752 -0.0401345197630827 0.208049771543413 -0.19290826164021 0.847030814711853 0.910384178717539 369 Glyoxalase-like domain protein NA K08234 NA Signal transduction 02020 Two-component system COG0346 Q LFTS_00995 504.695310837012 0.0292746696114644 0.152803187280144 0.191584155622312 0.848067954585249 0.911104984917429 441 hypothetical protein NA NA NA NA NA NA NA LFTS_00277 345.337495844705 -0.0352066882846234 0.184221340706061 -0.191110802633873 0.84843878434749 0.911109640556311 1257 putative arabinose efflux permease%2C MFS family NA K05820 NA Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG0477 GEPR LFTS_00640 33.7600344557846 0.064410370845454 0.345382205906124 0.186490125269977 0.852060421920445 0.914603717139131 786 putative DNA primase/helicase NA K02316 Replication and repair Replication and repair 03030 DNA replication COG0358 L LFTS_01279 166.043841341208 -0.0362049573326885 0.196168739845675 -0.184560278876088 0.853573943501333 0.915518743705621 714 hypothetical protein NA NA NA NA NA NA NA LFTS_01524 612.97042838134 0.0282479953055931 0.153201975755055 0.184384014412171 0.853712209473222 0.915518743705621 417 nucleoside diphosphate kinase NA K00940 Nucleotide metabolism; Signal transduction Nucleotide metabolism 00230 Purine metabolism COG0105 F LFTS_02090 54.5566576463302 -0.0524341689394673 0.284976662084491 -0.183994606982664 0.854017685701261 0.915518743705621 840 Peptidase C39 family protein NA K06992 NA Metabolism of cofactors and vitamins 00770 Pantothenate and CoA biosynthesis COG3271 R LFTS_02021 29.3665778973417 -0.0653263302299916 0.360087615490145 -0.181417875594168 0.856039588983409 0.917290697505498 324 hypothetical protein NA K07733 NA Overview 01230 Biosynthesis of amino acids COG3311 KX LFTS_00664 1024.78185086006 0.0367680391013318 0.204323477892484 0.179950143177767 0.857191709118561 0.918129508344999 1035 4-hydroxythreonine-4-phosphate dehydrogenase NA K00097 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00750 Vitamin B6 metabolism COG1995 H LFTS_02116 106.922154898068 -0.0422074461648579 0.235511653036058 -0.179215956496198 0.857768135089678 0.918351241960784 480 DNA-binding transcriptional regulator%2C MarR family NA K15973 NA Amino acid metabolism 00270 Cysteine and methionine metabolism COG1846 K LFTS_01871 180.140971904517 0.0429304400773601 0.242786467661415 0.176823858804314 0.859646747733627 0.918941873241029 171 hypothetical protein NA NA NA NA NA NA NA LFTS_01296 546.744639224074 0.0282534064000352 0.160402008411945 0.176141225909558 0.860182993626031 0.918941873241029 966 putative dehydrogenase NA K03810 NA Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG0673 R LFTS_01256 61.0211278775758 -0.059597194718783 0.339139360419658 -0.175730692671698 0.860505521255226 0.918941873241029 264 transcriptional regulator%2C y4mF family NA K15773 NA Overview 01210 2-Oxocarboxylic acid metabolism COG1396 K LFTS_00362 132.102545081881 -0.0373759291005956 0.213085483625421 -0.175403450599657 0.860762629433432 0.918941873241029 888 branched-chain amino acid aminotransferase NA K02619 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG0115 EH LFTS_02285 995.660137212408 -0.0331032208335951 0.189277104015439 -0.174892895819533 0.861163792556062 0.918941873241029 654 phosphate transport system protein NA K02039 NA Overview 01200 Carbon metabolism COG0704 P LFTS_02512 1028.63531916776 -0.0241275414688757 0.137964701080315 -0.174881989957925 0.861172362114829 0.918941873241029 1137 cobalt-precorrin 5A acetaldehyde-lyase NA K02189 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG2073 H LFTS_02211 242.497990810056 -0.0458097968960176 0.262000631610351 -0.174846131532027 0.861200538902278 0.918941873241029 255 hypothetical protein NA NA NA NA NA NA NA LFTS_01705 4533.68830204703 -0.0319812906729792 0.184401734802729 -0.173432699574071 0.862311323997526 0.918941873241029 2934 transaldolase NA K13810 Carbohydrate metabolism; Overview Overview 01200 Carbon metabolism NA LFTS_01762 75.2141912623721 0.0444664329541157 0.256454623159094 0.173389086951771 0.862345602540498 0.918941873241029 402 PIN domain nuclease%2C a component of toxin-antitoxin system (PIN domain) NA K07062 NA Amino acid metabolism 00260 Glycine, serine and threonine metabolism COG1487 R LFTS_01544 533.753850002386 0.0343674920076278 0.198258053612716 0.17334726827674 0.862378471324592 0.918941873241029 846 ketopantoate hydroxymethyltransferase NA K00606 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00770 Pantothenate and CoA biosynthesis COG0413 H LFTS_01953 487.012566462905 0.028474079838062 0.164269309231416 0.173337794937391 0.862385917245101 0.918941873241029 825 indole-3-glycerol phosphate synthase NA K01609 Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG0134 E LFTS_01375 562.95849288698 -0.0248596872839233 0.144725179469431 -0.171771680470945 0.863617030283095 0.919239481836594 1341 hypothetical protein NA K08509 Transport and catabolism; Folding, sorting and degradation Folding, sorting and degradation 04130 SNARE interactions in vesicular transport NA LFTS_01393 1062.45210781604 -0.0228730812639961 0.133278066718802 -0.171619245590162 0.863736876149914 0.919239481836594 2589 starch phosphorylase NA K00688 Endocrine system; Endocrine and metabolic diseases; Cellular community - prokaryotes; Carbohydrate metabolism Carbohydrate metabolism 00500 Starch and sucrose metabolism COG0058 G LFTS_01015 12.5593777713468 -0.07393021557997 0.430900628680094 -0.171571380172798 0.863774509078956 0.919239481836594 165 hypothetical protein NA NA NA NA NA NA NA LFTS_00617 664.598922267524 -0.0293749809308361 0.173303738437414 -0.169499984222466 0.865403384769556 0.920578868009036 789 hypothetical protein NA K01243 Amino acid metabolism; Overview Overview 01230 Biosynthesis of amino acids COG0775 F LFTS_01430 39.4068198562065 0.0541837737399014 0.321719327414797 0.168419392690205 0.866253352850682 0.921088894434044 1479 sulfate permease%2C SulP family NA K03321 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0659 P LFTS_00149 914.95091910648 -0.0249305319988105 0.15153822756785 -0.164516455015604 0.869324594005596 0.923959358998679 1284 Tetratricopeptide repeat-containing protein NA K02656 NA Folding, sorting and degradation 04122 Sulfur relay system COG3063 NW LFTS_02147 1052.41606316064 -0.0320781947759374 0.197626119259736 -0.162317586845784 0.871055766029556 0.925225371138908 1734 methyl-accepting chemotaxis protein Chemotaxis K03406 Signal transduction; Cell motility Signal transduction 02020 Two-component system COG0840 NT LFTS_01161 21.8581557007161 -0.0608411495987952 0.37542798625896 -0.162058109213064 0.871260094061216 0.925225371138908 1131 hypothetical protein NA NA NA NA NA NA NA LFTS_01344 280.143451453037 0.0282305830088281 0.177784129876945 0.158791355720942 0.87383325953444 0.927561692229982 1071 ferrochelatase NA K01772 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0276 H LFTS_01247 109.994295058796 0.0364117540205294 0.230048005609619 0.15827893801574 0.87423700395815 0.927594191993155 567 TolB amino-terminal domain-containing protein putative pel operon K07337 NA Translation 00970 Aminoacyl-tRNA biosynthesis COG3417 M LFTS_00971 228.080822730058 -0.0295407631851185 0.190047398614363 -0.15543892418681 0.876475299995826 0.929528733111174 1452 type IV secretion system protein VirB10 NA K03195 Membrane transport Membrane transport 03070 Bacterial secretion system COG2948 U LFTS_01321 761.538759878248 0.0284458087212842 0.183501463358224 0.155016794965572 0.876808076888859 0.929528733111174 1416 adenosylmethionine-8-amino-7-oxononanoate aminotransferase NA K00833 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00780 Biotin metabolism COG0161 H LFTS_01352 3506.54217338549 -0.0243858252443545 0.157900900799771 -0.15443753088703 0.877264763249186 0.929616454150672 1200 alanine-synthesizing transaminase NA K14261 NA Overview 01230 Biosynthesis of amino acids COG0436 E LFTS_00037 321.21810797673 -0.0285589610395245 0.186839419881857 -0.152852974268402 0.878514221109772 0.930543823467785 435 hypothetical protein NA NA NA NA NA NA NA LFTS_01552 441.694178956413 0.0250730347780342 0.164608922637608 0.152318807366435 0.878935491864287 0.930593540363976 333 hypothetical protein NA K09780 NA Overview 01230 Biosynthesis of amino acids COG2350 R LFTS_00973 176.383899999893 0.0319082823815088 0.210975461375003 0.151241676039247 0.879785075668041 0.931096508348552 1077 type IV secretion system protein VirB9 NA K03204 Membrane transport Membrane transport 03070 Bacterial secretion system COG3504 U LFTS_02414 2301.3900045815 -0.0207795255891422 0.138649828172627 -0.149870546996066 0.880866749319596 0.931844569705751 2070 hypothetical protein NA K06888 NA Membrane transport 03070 Bacterial secretion system COG1331 R LFTS_02280 960.572164695221 0.0267162037300096 0.179849969320732 0.148547168681279 0.881910963613602 0.932510050787659 1008 fructose-1%2C6-bisphosphatase I NA K03841 Carbohydrate metabolism; Overview; Signal transduction; Energy metabolism; Endocrine system Overview 01200 Carbon metabolism COG0158 G LFTS_01594 591.981775722059 -0.0234390922985001 0.158241188248487 -0.148122575152137 0.882246033569016 0.932510050787659 639 thiamine-phosphate pyrophosphorylase NA K00788 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00730 Thiamine metabolism COG0352 H LFTS_02089 24.9689242290897 0.0576801108078188 0.396660894743192 0.145414159984594 0.884383885439889 0.934372434850643 741 hypothetical protein NA NA NA NA NA NA NA LFTS_01033 39.2691914890092 0.0454371307711139 0.316103548339967 0.143741286707249 0.885704767640978 0.93537045554608 666 hypothetical protein NA NA NA NA NA NA NA LFTS_01258 5.42575952712191 0.0612032637110527 0.430181307221536 0.142273182687443 0.886864228140901 0.93602105323172 150 hypothetical protein NA K07473 NA Overview 01210 2-Oxocarboxylic acid metabolism COG3077 V LFTS_01924 600.847136260774 0.0204366407922521 0.144254089224018 0.141671136687953 0.887339774531523 0.93602105323172 522 tRNA threonylcarbamoyladenosine biosynthesis protein TsaE NA K06925 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0802 J LFTS_01492 654.868331985951 -0.0200731141724568 0.142383325118468 -0.140979388954115 0.887886224937762 0.93602105323172 1365 adenylate cyclase NA K01768 Cell growth and death; Aging; Cellular community - prokaryotes; Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG2114 T LFTS_01244 17.2773492225614 0.0557711736339219 0.397744270729462 0.140218672494359 0.888487219135062 0.93602105323172 903 hypothetical protein putative pel operon K05384 Energy metabolism Energy metabolism 00196 Photosynthesis - antenna proteins NA LFTS_00680 1515.73245526905 -0.0190795081268055 0.136131797615774 -0.140154677018638 0.888537780860929 0.93602105323172 912 farnesyl-diphosphate synthase NA K13789 Metabolism of terpenoids and polyketides Metabolism of terpenoids and polyketides 00900 Terpenoid backbone biosynthesis COG0142 H LFTS_01210 184.580595162243 -0.0389499643295538 0.278572267230819 -0.139819963834665 0.888802239381166 0.93602105323172 186 hypothetical protein NA NA NA NA NA NA NA LFTS_02326 71.1587849912394 -0.037407524509815 0.267914599595906 -0.139624807928484 0.888956438728918 0.93602105323172 2901 iron complex outermembrane recepter protein NA K02014 NA Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG1629 P LFTS_01354 1239.29681239981 0.0214015831314928 0.15430672666961 0.138695075667805 0.889691109538152 0.936086304374625 1332 homoserine dehydrogenase NA K00003 Amino acid metabolism; Overview Overview 01230 Biosynthesis of amino acids COG0460 E LFTS_00969 148.361261383023 0.0309752122187214 0.223646936708978 0.138500498484484 0.88984487567961 0.936086304374625 606 hypothetical protein NA NA NA NA NA NA NA LFTS_01159 3.28875797363109 -0.0568403363285867 0.411537914416489 -0.138116888717725 0.890148038431864 0.936086304374625 240 ORF6N domain-containing protein NA K00373 Signal transduction Signal transduction 02020 Two-component system COG2180 CPO LFTS_02073 144.34181717818 0.0464541994865308 0.338005493830719 0.137436226139555 0.890685998396361 0.936255979709663 1158 membrane fusion protein%2C multidrug efflux system NA K03585 Drug resistance Drug resistance 01501 beta-Lactam resistance COG0845 MV LFTS_01429 12.4821550053034 -0.0568167200393764 0.416770800011023 -0.136326057482611 0.891563525286962 0.9367823008721 864 Nucleotide-binding universal stress protein%2C UspA family NA K06149 NA Overview 01230 Biosynthesis of amino acids COG0589 T LFTS_01978 1127.03793411003 -0.0268160790670947 0.198813109486239 -0.134880839278613 0.89270608913956 0.937586538910412 996 homoserine kinase NA K00872 Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG0083 E LFTS_00573 5787.8457304 -0.0189080107842631 0.143210541272085 -0.132029462470502 0.89496098805292 0.939109861324374 1428 PilZ domain-containing protein c-di-GMP effector proteins; Extracellular polysaccharide production and export K02481 NA Nucleotide metabolism 00230 Purine metabolism COG2204 T LFTS_01186 27.8733488480529 0.0470699174176043 0.356523584519309 0.132024694750748 0.894964759132135 0.939109861324374 630 response regulator receiver and ANTAR domain protein NA K07183 NA Signal transduction 02020 Two-component system COG3707 TK LFTS_00012 153.754302279796 0.026542758384136 0.202732933964796 0.130924748461171 0.895834836752554 0.939109861324374 288 hypothetical protein NA K05663 Membrane transport Membrane transport 02010 ABC transporters NA LFTS_02240 342.894917409998 -0.0241868082809996 0.185144670618828 -0.130637345380548 0.896062198533024 0.939109861324374 99 hypothetical protein NA NA NA NA NA NA NA LFTS_02071 434.200678003323 -0.0560603367920163 0.430876956462091 -0.130107530586748 0.896481352220847 0.939109861324374 1503 efflux transporter%2C outer membrane factor (OMF) lipoprotein%2C NodT family Copper/silver resistance K07796 Signal transduction Signal transduction 02020 Two-component system COG1538 M LFTS_01857 58819.7167159967 -0.0248482915072275 0.191241235145501 -0.12993166190504 0.896620494039109 0.939109861324374 1383 cytochrome c oxidase cbb3-type subunit 1 Cytochrome cbb3 oxidase K00404 Energy metabolism; Signal transduction Energy metabolism 00190 Oxidative phosphorylation COG3278 C LFTS_02430 438.650653738317 0.0200190732716915 0.154344588809983 0.129703758492871 0.896800808843147 0.939109861324374 201 hypothetical protein NA K16263 NA Amino acid metabolism 00360 Phenylalanine metabolism COG0531 E LFTS_01179 7.78166600577747 0.0554640278556299 0.433842183666616 0.127843787311957 0.898272597091266 0.939987840479289 210 nitrogen fixation protein NifT Nitrogenase genes K02593 NA Overview 01210 2-Oxocarboxylic acid metabolism NA LFTS_01913 4047.95559417637 0.0217836366009647 0.17059977574219 0.127688541829528 0.898395458157196 0.939987840479289 198 hypothetical protein NA NA NA NA NA NA NA LFTS_00159 464.442244828775 0.0194055655911381 0.153908097978815 0.126085409708651 0.899664316661677 0.940919432570858 369 hypothetical protein NA NA NA NA NA NA NA LFTS_00978 68.1053387254044 -0.0331071790585295 0.264019948778387 -0.125396505876604 0.900209654188808 0.941093860518662 336 type IV secretion system protein VirB3 NA K03198 Membrane transport Membrane transport 03070 Bacterial secretion system COG3702 U LFTS_00446 920.285941826849 -0.0176543498703436 0.142164675850722 -0.124182394569529 0.901170861429772 0.941702716063226 1293 putative arabinose efflux permease%2C MFS family NA K08153 NA Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG0477 GEPR LFTS_01743 343.389246869739 0.0240384115568217 0.197863795889793 0.121489691677657 0.903303179075424 0.94336611398496 636 DNA-3-methyladenine glycosylase NA K03652 Replication and repair Replication and repair 03410 Base excision repair COG2094 L LFTS_00079 498.842718065787 -0.0248591322997025 0.205084817482907 -0.121213908493126 0.903521607963874 0.94336611398496 1203 putative arabinose efflux permease%2C MFS family NA K08153 NA Xenobiotics biodegradation and metabolism 00364 Fluorobenzoate degradation COG0477 GEPR LFTS_01869 1167.94019962656 0.0168008028435601 0.13973799265247 0.12023074415663 0.904300364102188 0.943412449039748 1521 Signal transduction histidine kinase NA K02484 NA Metabolism of terpenoids and polyketides 00900 Terpenoid backbone biosynthesis COG0642 T LFTS_00024 1045.4412449838 0.0266401171011979 0.221632168196989 0.120199686344808 0.904324966235607 0.943412449039748 1431 HD domain-containing protein NA K07814 NA Cell growth and death 04112 Cell cycle - Caulobacter COG3437 T LFTS_01080 42.1480244301766 0.0402290817119028 0.338400309336379 0.11888015643601 0.905370303132583 0.943782210289588 708 Methyltransferase domain-containing protein NA K00568 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00130 Ubiquinone and other terpenoid-quinone biosynthesis COG2227 H LFTS_01064 85.800812632668 -0.0299705171450403 0.252290151762917 -0.118793844847358 0.905438685253688 0.943782210289588 1263 YqaJ-like viral recombinase domain protein NA NA NA NA NA NA NA LFTS_00669 1580.21770058184 0.0163493839382247 0.138289050555289 0.118226163767667 0.905888459645344 0.943855285280103 1689 ribonuclease J NA K12574 Folding, sorting and degradation Folding, sorting and degradation 03018 RNA degradation COG0595 J LFTS_01508 256.779317898077 0.0218567064445764 0.187398877106219 0.116632003254683 0.907151675861995 0.944504134451287 708 general secretion pathway protein J NA K02459 Cellular community - prokaryotes; Membrane transport Membrane transport 03070 Bacterial secretion system COG2165 NUW LFTS_01788 106.72055981777 0.0281845235461217 0.242484077121869 0.116232471346795 0.907468302739936 0.944504134451287 984 Transposase NA K07497 NA Carbohydrate metabolism 00500 Starch and sucrose metabolism COG2801 X LFTS_01765 141.401124749303 -0.0267840495732794 0.230893097957686 -0.116001949864209 0.907650996461836 0.944504134451287 255 Plasmid stability protein NA NA NA NA NA NA NA LFTS_01781 1248.83393963925 0.0216234820876084 0.1889969576404 0.114411799838338 0.908911360500822 0.945419933977006 1176 CDP-6-deoxy-D-xylo-4-hexulose-3-dehydrase NA K12452 Carbohydrate metabolism Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG0399 M LFTS_01328 269.969153764405 -0.0207878781587184 0.184178577954343 -0.112868056587295 0.910135161614777 0.946296951808589 1641 Dolichyl-phosphate-mannose-protein mannosyltransferase Lipopolysaccharide synthesis K07264 Drug resistance Drug resistance 01503 Cationic antimicrobial peptide (CAMP) resistance COG1807 M LFTS_01305 721.696684796026 0.0154685912530571 0.138389123248461 0.111776062236373 0.911000968129009 0.946801173398293 1116 heptosyltransferase-1 Lipopolysaccharide synthesis K02841 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG0859 M LFTS_01014 37.3662038022907 0.0357829358712217 0.323816782585861 0.110503648345446 0.912009956630087 0.947453720092936 219 hypothetical protein NA NA NA NA NA NA NA LFTS_02423 1572.56665889312 -0.0240849173035044 0.221134950811211 -0.108915018703065 0.913269894309571 0.94836631464227 1092 RND family efflux transporter%2C MFP subunit Cadmium/cobalt/zinc resistance K15727 NA Signal transduction 02020 Two-component system COG0845 MV LFTS_00979 66.0517852396267 0.0300704547197906 0.284181661105226 0.105814198575805 0.915729771203155 0.950523679002523 330 TrbC/VIRB2 family protein NA K03197 Infectious diseases; Membrane transport Membrane transport 03070 Bacterial secretion system COG3838 U LFTS_02445 1098.20356915682 -0.0152603568537918 0.150752598427473 -0.101227819705765 0.91936961321053 0.953530877752372 1425 glutamyl-tRNA synthetase NA K09698 Translation Translation 00970 Aminoacyl-tRNA biosynthesis COG0008 J LFTS_01782 735.786973444136 -0.0163909466345281 0.161970544078889 -0.101197083258205 0.91939401205649 0.953530877752372 744 D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase Lipopolysaccharide synthesis K15669 Glycan biosynthesis and metabolism Glycan biosynthesis and metabolism 00540 Lipopolysaccharide biosynthesis COG1208 JM LFTS_02316 286.091419783583 0.0182289880640485 0.182036268727649 0.100139319441454 0.920233719802381 0.954003764565771 1755 NADH-quinone oxidoreductase subunit L NADH dehydrogenase K05577 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG1009 CP LFTS_00724 3701.21546584069 -0.0137937686535031 0.139097414918301 -0.0991662473497792 0.921006273440855 0.954406667684021 1668 general secretion pathway protein D NA K02453 Cellular community - prokaryotes; Membrane transport Membrane transport 03070 Bacterial secretion system COG1450 U LFTS_00006 287.674177120605 0.016796363404511 0.174307009161414 0.096360803190404 0.923234021733579 0.956316574179032 492 7-carboxy-7-deazaguanine synthase NA K10026 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG0602 R LFTS_01230 127.043111926407 -0.0197729679656142 0.212361266058318 -0.0931100493636358 0.925816133883177 0.958342564364523 267 Acetyltransferase (GNAT) family protein NA K09994 Metabolism of other amino acids Metabolism of other amino acids 00440 Phosphonate and phosphinate metabolism COG0454 KR LFTS_00144 633.162873076154 0.0148791979354338 0.160115673744314 0.0929278039275164 0.925960916976502 0.958342564364523 1005 anthranilate phosphoribosyltransferase NA K00766 Overview; Amino acid metabolism Overview 01230 Biosynthesis of amino acids COG0547 E LFTS_00039 461.36883457517 0.0153906885303243 0.166776164806615 0.0922835019510765 0.926472795967012 0.958473312848103 669 hypothetical protein NA NA NA NA NA NA NA LFTS_01162 3.54558681545697 -0.0367790225213737 0.404464005065398 -0.0909327457097867 0.927546030656152 0.959184455994673 876 nitrogenase iron protein NifH Nitrogenase genes K02588 Energy metabolism; Xenobiotics biodegradation and metabolism Energy metabolism 00910 Nitrogen metabolism COG1348 P LFTS_01759 113.459634996369 0.0224709453211913 0.250688287993357 0.0896369970095562 0.928575683369579 0.959713794305347 447 hypothetical protein NA NA NA NA NA NA NA LFTS_01136 132.371727659949 -0.0212400812932691 0.23780564921 -0.0893169752856146 0.928830003659962 0.959713794305347 549 CRISPR-associated protein%2C Cse2 family NA NA NA NA NA NA NA LFTS_00607 970.586669341391 -0.0113344394879942 0.128636771524258 -0.0881119710459837 0.929787681868907 0.960304186591651 1173 cell division protein FtsZ NA K03531 Cell growth and death Cell growth and death 04112 Cell cycle - Caulobacter COG0206 D LFTS_01790 275.086540573125 -0.0160138020360798 0.182895640587459 -0.0875570461091557 0.930228743244664 0.960360737419533 132 hypothetical protein NA NA NA NA NA NA NA LFTS_01902 779.767042334169 0.0115001195424673 0.136653035846187 0.0841556096522548 0.932932711299416 0.962752478327251 1551 GMP synthase (glutamine-hydrolysing) NA K01951 Xenobiotics biodegradation and metabolism; Nucleotide metabolism Nucleotide metabolism 00230 Purine metabolism COG0518;COG0519 F LFTS_01045 5.65064624856943 0.035253906737877 0.432295144791777 0.0815505498098013 0.935004125778639 0.964366593406469 156 hypothetical protein NA NA NA NA NA NA NA LFTS_01131 168.500446529161 0.0161024854547827 0.198275060622149 0.0812128636060237 0.935272669631133 0.964366593406469 2340 type IV secretion system protein VirD4 NA K03205 Membrane transport Membrane transport 03070 Bacterial secretion system COG3505 U LFTS_02386 1569.44018452312 -0.0141857370066239 0.177780213925163 -0.0797936772232446 0.936401353135591 0.964743926656935 1221 alanine racemase NA K01775 Metabolism of other amino acids; Drug resistance Metabolism of other amino acids 00473 D-Alanine metabolism COG0787 M LFTS_01460 409.868125357997 -0.01315825815268 0.164938364116314 -0.0797768198028254 0.93641476066902 0.964743926656935 2559 putative ABC transport system permease protein NA K02004 NA Folding, sorting and degradation 04130 SNARE interactions in vesicular transport COG0577;COG3127 VQ LFTS_01038 35.2311064056149 -0.029551294156439 0.378476802583745 -0.0780795387054144 0.937764783245456 0.965734569655429 345 hypothetical protein NA K00149 Amino acid metabolism; Metabolism of other amino acids; Carbohydrate metabolism; Lipid metabolism Carbohydrate metabolism 00010 Glycolysis / Gluconeogenesis NA LFTS_00164 655.554126260004 -0.0116144815871444 0.149827195965943 -0.0775191814294147 0.938210532612737 0.965793533778577 621 hypothetical protein NA K07285 NA Signal transduction 02020 Two-component system COG3065 M LFTS_00311 6.46876840042103 -0.0331745113336563 0.433834973440155 -0.0764680428380275 0.939046737632383 0.966254217613454 339 nitrogen regulatory protein P-II family protein Nitrate/nitrite regulation K04751 Signal transduction Signal transduction 02020 Two-component system COG0347 TE LFTS_00038 189.07292145128 -0.0164989425429304 0.223837741785688 -0.0737093861442154 0.941241630045146 0.968111995156075 606 multiple antibiotic resistance protein NA K05595 NA Membrane transport 02010 ABC transporters COG2095 E LFTS_00466 608.802784493906 -0.0109061623926769 0.14966152933747 -0.0728721832588299 0.941907829618794 0.968396552701539 1263 Fe-S oxidoreductase NA K00113 Lipid metabolism Lipid metabolism 00564 Glycerophospholipid metabolism COG0247 C LFTS_00318 501.908615348469 -0.0137432634365819 0.190925126293715 -0.071982476604151 0.942615853315032 0.96872385752012 453 thioredoxin Oxidative stress response K03672 NA Signal transduction 02020 Two-component system COG0526 O LFTS_00684 464.481983931291 -0.0103827863609783 0.148500068116114 -0.069917721201716 0.944259148167167 0.969612947526843 342 divalent cation tolerance protein Copper resistance K03926 NA Folding, sorting and degradation 03060 Protein export COG1324 P LFTS_01931 509.820902659962 -0.0104335520669537 0.149231219628103 -0.0699153440744841 0.944261040210171 0.969612947526843 1089 SAM-dependent methyltransferase%2C MidA family NA NA NA NA NA NA NA LFTS_00898 795.373659809563 -0.00990633415485307 0.143444246430655 -0.0690605193401192 0.944941446965954 0.969910998000562 837 protein TonB NA K03832 NA Metabolism of cofactors and vitamins 00790 Folate biosynthesis COG0810 M LFTS_00867 2259.25067447786 -0.00943316747108567 0.138420009128786 -0.0681488719041267 0.945667126600532 0.970191325790287 2715 valyl-tRNA synthetase NA K01873 Translation Translation 00970 Aminoacyl-tRNA biosynthesis COG0525 J LFTS_00709 625.479669629717 0.00962027906008065 0.142024219212427 0.06773689102766 0.945995081945155 0.970191325790287 3108 PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein Genes encoding proteins with EAL and GGDEF domains K14051 Cellular community - prokaryotes Cellular community - prokaryotes 02024 Quorum sensing COG2199;COG2200;COG2202 T LFTS_01630 307.995770344887 0.0117544308359469 0.178393882227154 0.0658903247644988 0.947465143563712 0.971298287381191 1290 Major Facilitator Superfamily protein NA K08217 NA Carbohydrate metabolism 00630 Glyoxylate and dicarboxylate metabolism COG0477 GEPR LFTS_01975 20.7674556736731 0.0238422930909563 0.375896553147446 0.0634278045151536 0.949425847020821 0.972907112816884 132 hypothetical protein NA NA NA NA NA NA NA LFTS_02216 41.3349481472642 0.0206795328289502 0.33515504470293 0.0617013921043018 0.950800631344806 0.973803956045703 225 hypothetical protein NA NA NA NA NA NA NA LFTS_02059 241.335510341115 0.0114795958664098 0.188061508413379 0.0610417089773438 0.951325992008263 0.973803956045703 2925 iron complex outermembrane recepter protein NA K02014 NA Cell growth and death 04112 Cell cycle - Caulobacter COG1629 P LFTS_02086 51.1993754958581 -0.0189557204065538 0.313831137885377 -0.0604010186314817 0.951836247389916 0.973803956045703 1566 OmpA family protein NA K03640 NA Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG2885 M LFTS_02186 272.439026805162 0.0124768647981345 0.206780984259868 0.0603385501949949 0.951885999247671 0.973803956045703 954 squalene synthase HpnC NA K02291 Metabolism of terpenoids and polyketides Metabolism of terpenoids and polyketides 00906 Carotenoid biosynthesis COG1562 I LFTS_01602 682.233681507829 0.0147446824585667 0.246280620294706 0.0598694385328526 0.952259620734957 0.973803956045703 207 hypothetical protein NA NA NA NA NA NA NA LFTS_02262 548.883842083248 -0.00930884656011419 0.159701927315162 -0.0582888805201691 0.953518524516152 0.974690399649323 357 histidine triad (HIT) family protein NA K02503 NA Overview 01230 Biosynthesis of amino acids COG0537 FGR LFTS_01111 52.6243029565268 0.018802634449576 0.341933041210637 0.0549892294204853 0.956147044487885 0.976975566213269 1005 hypothetical protein NA K02314 Replication and repair; Cell growth and death Replication and repair 03030 DNA replication COG0305 L LFTS_00439 262.499173783658 -0.0127818236296708 0.236306991297517 -0.0540899088913461 0.956863532017136 0.977305973950124 1605 cytochrome d ubiquinol oxidase subunit I Cytochrome bd K00425 Energy metabolism; Signal transduction Energy metabolism 00190 Oxidative phosphorylation COG1271 C LFTS_01721 763.135142834672 0.00985614326931349 0.189422593530944 0.052032564255348 0.958502746025463 0.97807587646844 552 EamA-like transporter family protein Lipopolysaccharide synthesis K12962 Drug resistance Drug resistance 01503 Cationic antimicrobial peptide (CAMP) resistance COG0697 GER LFTS_01849 2405.9065831279 0.00647914926957537 0.125170591932972 0.0517625519662389 0.958717894730254 0.97807587646844 1197 hypothetical protein NA NA NA NA NA NA NA LFTS_00972 167.949631407547 0.010977839523063 0.213539054203815 0.0514090481668286 0.958999574914244 0.97807587646844 573 hypothetical protein NA K01317 NA Membrane transport 03070 Bacterial secretion system NA LFTS_00291 295.807054822008 -0.010292991176206 0.201157818071056 -0.0511687354481552 0.959191064694311 0.97807587646844 627 Holliday junction DNA helicase subunit RuvA NA K03550 Replication and repair Replication and repair 03440 Homologous recombination COG0632 L LFTS_00298 1754.29229335785 -0.00825420040643507 0.163087195521631 -0.0506121917176524 0.95963454769175 0.978126890349196 672 phosphoribosylformylglycinamidine synthase NA NA NA NA NA NA NA LFTS_00929 1022.39778195154 0.00646519118055698 0.131669899474925 0.0491015122388559 0.960838398270586 0.97895256479536 1788 arginyl-tRNA synthetase NA K01887 Translation Translation 00970 Aminoacyl-tRNA biosynthesis COG0018 J LFTS_00687 1824.10348887284 0.00593433373673511 0.122522783633994 0.0484345324251075 0.961369938693917 0.979092858497779 372 NADH dehydrogenase subunit A NADH dehydrogenase K00330 Energy metabolism Energy metabolism 00190 Oxidative phosphorylation COG0838 C LFTS_02136 140.665084124552 0.0117959672279482 0.255536203674594 0.0461616282089307 0.963181426106185 0.980536046396386 1563 Bacterial Ig-like domain (group 3) NA K01361 NA Translation 03010 Ribosome COG1404 O LFTS_01184 10.1038948464951 0.0197049750132726 0.431588267017668 0.0456568830043425 0.963583730324125 0.980544066142356 327 nitrogen regulatory protein P-II family protein Nitrate/nitrite regulation K02589 NA Signal transduction 02020 Two-component system COG0347 TE LFTS_01391 1041.73653676381 0.00698255641551312 0.156557105929516 0.0446006993681703 0.964425585200983 0.980999183637333 1386 dihydrolipoamide dehydrogenase NA K00382 Carbohydrate metabolism; Amino acid metabolism; Overview Overview 01200 Carbon metabolism COG1249 C LFTS_01223 48.4171311773958 0.0130412330558338 0.304494397624189 0.0428291395755972 0.965837735273407 0.981690227944464 240 hypothetical protein NA NA NA NA NA NA NA LFTS_02193 1032.89128321255 0.00589655056339649 0.137906353666728 0.0427576424625541 0.965894729506098 0.981690227944464 1611 hypothetical protein NA K11274 NA Carbohydrate metabolism 00630 Glyoxylate and dicarboxylate metabolism NA LFTS_02207 2632.70262295302 -0.00540965670210815 0.140900042626527 -0.0383935774700021 0.969373881644811 0.984618660333699 4875 putative helicase NA K01153 NA Glycan biosynthesis and metabolism 00550 Peptidoglycan biosynthesis COG0610 V LFTS_01600 4111.99706531288 0.0137631577295194 0.360765334354515 0.0381498897452122 0.969568173973007 0.984618660333699 1053 hypothetical protein NA K06115 NA Cellular community - prokaryotes 02024 Quorum sensing NA LFTS_01982 1698.02511789643 -0.00585198693974322 0.164527924616066 -0.0355683508036652 0.971626544745517 0.985732843763696 798 proteasome beta subunit NA K03433 Folding, sorting and degradation Folding, sorting and degradation 03050 Proteasome COG0638 O LFTS_01542 794.271014853587 0.00594304905424622 0.170825035362488 0.0347902697144781 0.972246979579112 0.985732843763696 885 methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase NA K01491 Metabolism of cofactors and vitamins; Energy metabolism; Overview Overview 01200 Carbon metabolism COG0190 H LFTS_01601 2470.96711615578 0.0128104137140406 0.368627883803968 0.0347516134206849 0.972277804199706 0.985732843763696 855 hypothetical protein NA K07114 NA Cellular community - prokaryotes 02024 Quorum sensing COG2304 R LFTS_02019 291.930548143388 0.00620502148916761 0.180521400386454 0.0343727750609298 0.972579892992926 0.985732843763696 723 Helix-turn-helix domain protein NA NA NA NA NA NA NA LFTS_02001 219.990626249421 0.00667011565365542 0.194534921712656 0.0342874975605033 0.972647894510196 0.985732843763696 708 YbbR-like protein NA NA NA NA NA NA NA LFTS_00883 855.813362749718 0.00469618886754241 0.159286758236081 0.0294826068378021 0.976479690644561 0.989212922144408 564 putative arylsulfatase NA K07177 Cellular community - prokaryotes Cellular community - prokaryotes 02024 Quorum sensing COG3480 T LFTS_02247 604.983707688926 -0.00451024819596437 0.157835936961459 -0.028575546753118 0.977203114982586 0.989252903039249 897 Oligoribonuclease NrnB or cAMP/cGMP phosphodiesterase%2C DHH superfamily NA K07097 NA Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG2404 JT LFTS_01853 145.036504278154 -0.00593992072687908 0.20889291547325 -0.0284352425903104 0.977315016035557 0.989252903039249 774 Threonine/homoserine efflux transporter RhtA NA K15269 NA Folding, sorting and degradation 03060 Protein export COG0697 GER LFTS_01896 288.181158967251 0.00503006607442599 0.18022942273505 0.0279092392246106 0.977734539479439 0.989274751789127 480 Acetyltransferase (GNAT) family protein NA K03789 NA Replication and repair 03030 DNA replication COG0456 J LFTS_01058 14.0219845812416 -0.0113747229268353 0.415045890922651 -0.0274059403444501 0.978135960319904 0.989278273944378 261 hypothetical protein NA K07319 NA Energy metabolism 00190 Oxidative phosphorylation COG0863 L LFTS_00566 154.056651054177 -0.00556128862014383 0.218475640529373 -0.0254549596772833 0.979692073804941 0.990446833885577 1026 UDP-glucuronate 4-epimerase Extracellular polysaccharide production and export K08679 Carbohydrate metabolism Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG0451 M LFTS_00866 927.730725817776 0.00325886975300069 0.130572279054655 0.0249583585167919 0.980088178342123 0.990446833885577 1026 hypothetical protein NA K07082 NA Translation 00970 Aminoacyl-tRNA biosynthesis COG1559 D LFTS_02281 232.417166987657 -0.00452557236601308 0.189951005711477 -0.0238249455382569 0.980992242032766 0.990957624418309 159 hypothetical protein NA NA NA NA NA NA NA LFTS_00295 388.973510445872 0.00402154419478173 0.173447026029648 0.023186008355625 0.981501899323271 0.991069748869883 1641 HAMP domain-containing protein NA K02482 NA Signal transduction 02020 Two-component system COG0642 T LFTS_01862 534.193062873532 -0.00416956393823695 0.187654240422328 -0.0222193963155487 0.982272945387254 0.991142325066213 636 undecaprenyl-diphosphatase NA K01096 Lipid metabolism Lipid metabolism 00564 Glycerophospholipid metabolism COG0671 I LFTS_02023 62.2626642116891 0.00647223478273791 0.292910609538781 0.0220962797931052 0.982371154047928 0.991142325066213 804 plasmid and phage iteron-binding protein NA NA NA NA NA NA NA LFTS_02525 1084.2651081145 -0.00340382537574167 0.159359895742234 -0.0213593599562049 0.982958992220005 0.991333085054334 1689 hopanoid C-3 methylase HpnR NA K04034 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG1032 R LFTS_02033 3.76014078427021 0.00830895692718889 0.41271796613322 0.0201322879278458 0.983937843318886 0.991917874489355 195 hypothetical protein NA NA NA NA NA NA NA LFTS_00784 8575.01908620308 -0.00287858501937258 0.152967532837806 -0.0188182744793615 0.984986075477675 0.992572105244224 1389 hydroxymethylpyrimidine synthase NA K03147 Metabolism of cofactors and vitamins Metabolism of cofactors and vitamins 00730 Thiamine metabolism COG0422 H LFTS_02486 1655.52683538208 -0.0026491861423304 0.147212215567548 -0.0179956950727015 0.985642287690413 0.99283092674164 1563 phosphoenolpyruvate carboxylase Reductive TCA cycle carbon dioxide fixation K01595 Energy metabolism; Overview; Carbohydrate metabolism Overview 01200 Carbon metabolism COG2352;COG1892 CG LFTS_02521 202.925800185112 0.00333183505409005 0.1938863031536 0.0171844787377812 0.986289444535256 0.993080420864579 966 Permease of the drug/metabolite transporter (DMT) superfamily protein NA K03298 NA Metabolism of cofactors and vitamins 00860 Porphyrin and chlorophyll metabolism COG0697 GER LFTS_02246 430.921096009443 -0.00240832103981824 0.154527647504669 -0.0155850495280818 0.987565432984041 0.993962617975031 738 ribonuclease PH NA K00989 NA Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism COG0689 J LFTS_02223 2.62482814475908 0.00535258775571444 0.382656483927973 0.0139879708838854 0.988839577943531 0.99484224636488 1035 hypothetical protein NA NA NA NA NA NA NA LFTS_00383 25.8129230709039 0.00473108052332836 0.377412060395299 0.012535583834743 0.98999831314391 0.995605099707023 924 putative DNA primase/helicase NA K02316 Replication and repair Replication and repair 03030 DNA replication COG0358 L LFTS_00637 39.3327195273802 -0.00365669006024042 0.316050626816042 -0.0115699503496596 0.990768721202812 0.99597696761431 261 hypothetical protein NA NA NA NA NA NA NA LFTS_01050 5.48460273836964 0.00448457312684192 0.43040004279781 0.0104195461917011 0.991686555390886 0.996496676112264 138 hypothetical protein NA NA NA NA NA NA NA LFTS_01851 67.2031557083593 -0.00285985368924485 0.299581446202372 -0.00954616424180346 0.992383378619587 0.996793971413452 1542 MFS transporter%2C DHA2 family%2C multidrug resistance protein NA K03446 NA Folding, sorting and degradation 03060 Protein export COG0477 GEPR LFTS_00310 19.5863210121424 0.00306230781637975 0.401510809653457 0.0076269623201996 0.993914623517232 0.997921158102586 1473 ammonium transporter%2C Amt family Ammonia & glutamate conversion to glutamine K03320 NA Signal transduction 02020 Two-component system COG0004 P LFTS_01116 31.9497010670924 0.00244603658809776 0.342898638991206 0.00713341002254748 0.994308410547106 0.997921158102586 525 hypothetical protein NA K12080 NA Signal transduction 02020 Two-component system COG3451 U LFTS_00718 192.389964650046 -0.00138785948468641 0.225042090769733 -0.00616711069444558 0.995079388783302 0.998214417124277 591 Type II secretion system (T2SS)%2C protein M NA K02462 Cellular community - prokaryotes; Membrane transport Membrane transport 03070 Bacterial secretion system COG3149 U LFTS_00639 65.0423630573022 -0.00153676956048967 0.26676928925515 -0.00576066894649118 0.995403676609446 0.998214417124277 987 AAA domain-containing protein NA K07505 NA Replication and repair 03030 DNA replication COG3598 L LFTS_00632 436.767441372042 0.00104294699962978 0.199807773535729 0.00521975187038099 0.995835259483364 0.998244538336953 588 Terminase small subunit NA K07474 NA Replication and repair 03030 DNA replication COG3728 X LFTS_01272 440.985456915031 0.000745225706939549 0.186810885410138 0.00398919851647524 0.996817088535714 0.998825990366701 333 hypothetical protein NA NA NA NA NA NA NA LFTS_00165 887.892171304743 0.000438904766256904 0.157326887379088 0.00278976323480765 0.997774093873941 0.999045884524331 1377 Outer membrane protein TolC NA K15725 NA Signal transduction 02020 Two-component system COG1538 M LFTS_00405 1857.05496155853 -0.000255147373056583 0.118412300344596 -0.00215473706966311 0.998280769889893 0.999045884524331 2655 PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein Genes encoding proteins with EAL and GGDEF domains K14051 Cellular community - prokaryotes Cellular community - prokaryotes 02024 Quorum sensing COG2199;COG2200;COG2202 T LFTS_00315 214.900354396976 -0.000372004004127716 0.209802214894124 -0.00177311762087663 0.998585257567127 0.999045884524331 762 Ni/Fe-hydrogenase 1 B-type cytochrome subunit NA K03620 Signal transduction Signal transduction 02020 Two-component system COG1969 C LFTS_00562 188.350618305643 0.000333128989460486 0.196018752212361 0.00169947510480826 0.998644015705134 0.999045884524331 1116 diguanylate cyclase (GGDEF) domain-containing protein Putative diguanylate cyclases (GGDEF domain-containing proteins) K13590 Cell growth and death Cell growth and death 04112 Cell cycle - Caulobacter COG2199 T LFTS_02439 1243.88154679138 -0.000118434990710674 0.16601683680692 -0.0007133914426307 0.999430796030397 0.999430796030397 537 regulatory protein%2C Fis family NA K03557 Cellular community - prokaryotes Cellular community - prokaryotes 05111 Biofilm formation - Vibrio cholerae COG2901 K